American Journal of Transplantation最新文献_第10页

Development of a natural language processing algorithm to extract social determinants of health from clinician notes. 开发一种自然语言处理算法，从临床医生笔记中提取健康的社会决定因素。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-06 DOI: 10.1016/j.ajt.2025.02.019

Hamed Zaribafzadeh, Jacqueline B Henson, Norine W Chan, Ursula Rogers, Wendy Webster, Tyler Schappe, Fan Li, Roland A Matsouaka, Allan D Kirk, Ricardo Henao, Lisa M McElroy

{"title":"Development of a natural language processing algorithm to extract social determinants of health from clinician notes.","authors":"Hamed Zaribafzadeh, Jacqueline B Henson, Norine W Chan, Ursula Rogers, Wendy Webster, Tyler Schappe, Fan Li, Roland A Matsouaka, Allan D Kirk, Ricardo Henao, Lisa M McElroy","doi":"10.1016/j.ajt.2025.02.019","DOIUrl":"10.1016/j.ajt.2025.02.019","url":null,"abstract":"Disparities in access to the organ transplant waitlist are well-documented, but research into modifiable factors has been limited due to a lack of access to organized prewaitlisting data. This study aimed to develop a natural language processing (NLP) algorithm to extract social determinants of health (SDOH) from free-text notes and quantify the association of SDOH with access to the transplant waitlist. We collected 261 802 clinician notes from 11 111 adults referred for kidney or liver transplants between 2016 and 2022 at the Duke University Health System. An SDOH ontology and a rule-based NLP algorithm were created to extract and organize terms. Education, transportation, and age were the most frequent terms identified. Negative sentiment and refer were the most negatively associated features with listing in both kidney and liver transplant patients. Income and employment for the kidney, and judgment and positive sentiment for liver were the most positively associated features with the listing. This study suggests that the integration of NLP tools into the transplant clinical workflow could help improve collection and organization of SDOH and inform center-level efforts at resource allocation, potentially improving access to the transplant waitlist and posttransplant outcomes.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ABO-A antibody induction in mice is T cell-dependent, estrogen-independent, and modulated by CD22. 小鼠ABO-A抗体的诱导是t细胞依赖性的，不依赖于雌激素，并由CD22调节。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-06 DOI: 10.1016/j.ajt.2025.03.001

Ibrahim Adam, Bruce Motyka, Jean Pearcey, Kesheng Tao, Peter J Cowan, Lori J West

{"title":"ABO-A antibody induction in mice is T cell-dependent, estrogen-independent, and modulated by CD22.","authors":"Ibrahim Adam, Bruce Motyka, Jean Pearcey, Kesheng Tao, Peter J Cowan, Lori J West","doi":"10.1016/j.ajt.2025.03.001","DOIUrl":"10.1016/j.ajt.2025.03.001","url":null,"abstract":"ABO antibodies pose barriers in transplantation but remain poorly studied. We investigated anti-A natural antibodies (nAbs) and induced antibodies (iAbs) in wild-type (WT), CD19KO, and CD22KO mice in the context of major histocompatibility complex-syngeneic or major histocompatibility complex-allogeneic stimulation by ABO-A blood cell membranes (BCM) from A-transgenic mice, or xenogeneic human (Hu-A) BCM. CD19KO mice failed to produce anti-A nAbs and iAbs. Syngeneic A-transgenic-BCM failed to stimulate anti-A iAbs in WT mice, in contrast to allogeneic A-transgenic-BCM and xenogeneic Hu-A-BCM. Hu-A-BCM failed to stimulate anti-A iAbs in CD4-T cell-depleted or CD4KO mice, reversed with CD4-T cell reconstitution. Although anti-A nAbs were absent in estrogen-receptor-α-deficient mice, anti-A iAbs were easily stimulated. Anti-A nAbs were higher in CD22KO than in WT mice, with pubertal females producing higher levels than males. Anti-A iAbs were stimulated in CD22KO mice by syngeneic A-transgenic-BCM or by Hu-A-BCM after CD4T cell depletion. We conclude that anti-A nAbs and iAbs are produced by B1a-cells. In WT mice, stimulation of anti-A iAbs requires exposure to nonself A-antigen together with foreign proteins and is T cell dependent. Without CD22-mediated inhibition, anti-A iAb stimulation does not require foreign protein and is T cell-independent. Anti-A iAbs are estrogen-independent, whereas anti-A nAbs are estrogen-dependent and could be elicited by estrogen in males.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stepping stones: Hepatitis C virus infection and pediatric kidney transplantation. 垫脚石：丙型肝炎病毒感染和儿童肾移植。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-01 DOI: 10.1016/j.ajt.2025.02.017

Sharon Bartosh, Chris Callaghan

引用次数: 0

Is operational tolerance induction finally safe and feasible for some kidney transplant recipients: a breakthrough to a new horizon? 对于一些肾移植受者来说，手术耐受诱导最终是安全可行的吗？

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-22 DOI: 10.1016/j.ajt.2025.02.013

Edward K Geissler, Birgit Sawitzki

引用次数: 0

Direct and indirect allorecognition—not so different after all? 直接异体识别和间接异体识别——其实差别不大？

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-22 DOI: 10.1016/j.ajt.2025.02.014

Gavin J. Pettigrew

引用次数: 0

DCDD HEART TRANSPLANTATION WITH THORACO-ABDOMINAL NORMOTHERMIC REGIONAL PERFUSION AND STATIC COLD STORAGE: THE EXPERIENCE IN SPAIN. 胸腹恒温区域灌注和静态冷藏的DCDD心脏移植：西班牙的经验。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-22 DOI: 10.1016/j.ajt.2025.02.006

Alicia Pérez-Blanco, Francisco González-Vilchez, José González-Costello, Mario Royo-Villanova, Eduardo Miñambres, José J Cuenca, Sergio J Cánovas, Iris P Garrido, Gabriel Moreno-González, Fabrizio Sbraga, Antonio García-Quintana, Vicente J Peña, Francisco A Portela, Luis Almenar-Bonet, Juan Martínez-León, Ana Tur, Ángel Ruiz-Arranz, Pedro Caravaca-Pérez, Elena Sandoval, Manuel Gómez-Bueno, Marina Pérez-Redondo, Susana Villar, Manuel Cobo, J Francisco Nistal, Beatriz Domínguez-Gil

{"title":"DCDD HEART TRANSPLANTATION WITH THORACO-ABDOMINAL NORMOTHERMIC REGIONAL PERFUSION AND STATIC COLD STORAGE: THE EXPERIENCE IN SPAIN.","authors":"Alicia Pérez-Blanco, Francisco González-Vilchez, José González-Costello, Mario Royo-Villanova, Eduardo Miñambres, José J Cuenca, Sergio J Cánovas, Iris P Garrido, Gabriel Moreno-González, Fabrizio Sbraga, Antonio García-Quintana, Vicente J Peña, Francisco A Portela, Luis Almenar-Bonet, Juan Martínez-León, Ana Tur, Ángel Ruiz-Arranz, Pedro Caravaca-Pérez, Elena Sandoval, Manuel Gómez-Bueno, Marina Pérez-Redondo, Susana Villar, Manuel Cobo, J Francisco Nistal, Beatriz Domínguez-Gil","doi":"10.1016/j.ajt.2025.02.006","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.02.006","url":null,"abstract":"Heart transplantation from donors after the circulatory determination of death (DCDD) is expanding worldwide. Thoraco-abdominal normothermic regional perfusion (TA-NRP) allows the validation and recovery of the DCDD heart, but there is limited evidence on the results of heart transplants performed with this approach. This multicenter, nationwide, prospective study describes the short-term outcomes of adult patients receiving a DCDD heart transplant obtained via TA-NRP followed by static cold storage in Spain. Recipients of hearts from donors after the neurological determination of death (DNDD) were used as controls. The primary outcome was a composite of 1-year all-cause death or severe primary graft failure (PGF). During 2020-2023, 98 adult DCDD and 347 DNDD heart transplants were performed across 11 centers. The primary outcome was met by 21 (21.4%) and 77 (22.2%) patients, respectively (p=0.87). Thirty-day and 1-year survival were 94.9% and 88.8% in the DCDD vs 93.7% and 87.3% in the DNDD group (p=0.70). Severe PGF was observed in 13 (13.3%) vs 52 (15.0%) patients (p=0.67). By inverse probability weighting, the DCDD heart was not associated with the primary outcome (HR 0.97;95%CI 0.58-1.62;p=0.91). In conclusion, adult DCDD heart transplantation based on TA-NRP and static cold storage provides similar short-term outcomes than DNDD heart transplants.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative C1-esterase inhibitor therapy to allow transplantation in a highly sensitized lung transplant candidate: Three case reports. 围手术期c1 -酯酶抑制剂治疗允许高度敏感的肺移植候选者移植：三例报告。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-18 DOI: 10.1016/j.ajt.2025.02.009

Jérôme Devaquet, Benjamin Coiffard, Xavier Demant, François Parquin, Magali Devriese, Edouard Sage, Pascal Pedini, Clément Picard, Florence Daviet, Xavier Benoit D'Journo, Gwendaline Guidicelli, Natalia Belousova, Antoine Roux

引用次数: 0

Gut microbiome alterations precede graft rejection in kidney transplantation patients. 肾移植患者的肠道微生物改变先于移植排斥反应。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-18 DOI: 10.1016/j.ajt.2025.02.010

Johannes Holle, Rosa Reitmeir, Felix Behrens, Dharmesh Singh, Daniela Schindler, Olena Potapenko, Victoria McParland, Harithaa Anandakumar, Nele Kanzelmeyer, Claudia Sommerer, Steffen Hartleif, Joachim Andrassy, Uwe Heemann, Michael Neuenhahn, Sofia K Forslund-Startceva, Markus Gerhard, Jun Oh, Nicola Wilck, Ulrike Löber, Hendrik Bartolomaeus

{"title":"Gut microbiome alterations precede graft rejection in kidney transplantation patients.","authors":"Johannes Holle, Rosa Reitmeir, Felix Behrens, Dharmesh Singh, Daniela Schindler, Olena Potapenko, Victoria McParland, Harithaa Anandakumar, Nele Kanzelmeyer, Claudia Sommerer, Steffen Hartleif, Joachim Andrassy, Uwe Heemann, Michael Neuenhahn, Sofia K Forslund-Startceva, Markus Gerhard, Jun Oh, Nicola Wilck, Ulrike Löber, Hendrik Bartolomaeus","doi":"10.1016/j.ajt.2025.02.010","DOIUrl":"10.1016/j.ajt.2025.02.010","url":null,"abstract":"Kidney transplantation (KT) is the best treatment for end-stage kidney disease, with graft survival critically affected by the recipient's immune response. The role of the gut microbiome in modulating this immune response remains underexplored. Our study investigates how microbiome alterations might be associated with allograft rejection by analyzing the gut microbiome using 16S rRNA gene amplicon sequencing of a multicenter prospective study involving 562 samples from 245 individuals of whom 217 received KT. Overall, gut microbiome composition showed gradual recovery post-KT, mirroring chronic kidney disease (CKD)-to-health transition as indicated by an increase in Shannon diversity. Prior to graft rejection, we observed a decrease in microbial diversity and short-chain fatty acid-producing taxa. Functional analysis highlighted a decreased potential for short-chain fatty acid production in patients preceding the rejection event, validated by quantitative PCR for the production potential of propionate and butyrate. Postrejection analysis revealed normalization of these microbiome features. Comparison to published microbiome signatures from CKD patients demonstrated a partial overlap of the microbiome alterations preceding graft rejection with the alterations typically found in CKD. Our findings suggest that alterations in gut microbiome composition and function may precede and influence KT rejection, suggesting potential implications as biomarkers or for early therapeutic microbiome-targeting interventions.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between out-of-sequence allocation and deceased donor kidney nonuse across organ procurement organizations. 跨器官采购组织不合顺序分配与已故供者肾脏未利用之间的关系。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-17 DOI: 10.1016/j.ajt.2025.02.005

Joel T Adler, David C Cron, Arnold E Kuk, Miko Yu, Sumit Mohan, S Ali Husain, Layla Parast

引用次数: 0

Longer travel and traffic are associated with adult liver transplant waitlist mortality in the United States. 在美国，较长的旅行和交通与成人肝移植等待名单死亡率有关。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-02-17 DOI: 10.1016/j.ajt.2025.02.002

Kali Zhou, Robert Albertian, Christopher Wong, Leane S Kuo, Laura K Thompson, Jennifer L Dodge, Neil Mehta, Norah A Terrault, Myles G Cockburn

{"title":"Longer travel and traffic are associated with adult liver transplant waitlist mortality in the United States.","authors":"Kali Zhou, Robert Albertian, Christopher Wong, Leane S Kuo, Laura K Thompson, Jennifer L Dodge, Neil Mehta, Norah A Terrault, Myles G Cockburn","doi":"10.1016/j.ajt.2025.02.002","DOIUrl":"10.1016/j.ajt.2025.02.002","url":null,"abstract":"Transportation to transplant centers is a barrier to liver transplantation (LT). We analyzed the impact of travel metrics on LT waitlist outcomes in the United States. A total of 83 640 adult LT candidates in the Scientific Registry of Transplant Recipients database (2013-2021) were included. Google Distance Matrix application programming interface estimated driving time from patients' residing ZIP code to listing center. Effect of travel time (short [<1 hour], medium [1 to < 3 hours], or long [3 to < 6 hours]), traffic congestion in metropolitan areas, and center mismatch (defined as listing at a center >1 hour from nearest center) on waitlist mortality were examined using multivariable competing risk regression with adjustment for confounders. Compared to short travel, medium (HR 1.09 [95% CI: 1.05-1.13]) and long travel times (HR 1.14 [95% CI: 1.08-1.20]) were associated with higher waitlist mortality. Both high (HR 1.09 [95% CI: 1.01-1.12]) and moderate traffic (HR 1.09 [95% CI 1.02-1.15]) was also associated with higher waitlist mortality compared to low traffic. Lastly, there was no relationship between center mismatch (9.1% of listed) and waitlist deaths. Longer travel and traffic congestion are associated with greater waitlist mortality for adult LT candidates. Strategies to address these underrecognized spatial barriers to LT are needed.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0