American Journal of Transplantation最新文献_第2页

Continuous donor-recipient age matching in the Eurotransplant region: outcomes, parameters and prediction. 连续供体-受体年龄匹配在欧洲移植地区：结果，参数和预测。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-01-16 DOI: 10.1016/j.ajt.2025.01.011

Maarten Coemans,Maarten Naesens

引用次数: 0

Normothermic regional and ex-situ perfusion reduces Postreperfusion syndrome in donation after circulatory death liver transplantation: a retrospective comparative study. 常温区域和离体灌注可减少循环死亡肝移植术后捐献后灌注综合征：一项回顾性比较研究。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-01-16 DOI: 10.1016/j.ajt.2025.01.007

Anand Puttappa,Rohit Gaurav,Vibhay Kakhandki,Lisa Swift,Corrina Fear,Rachel Webster,Ahmed Radwan,Musab Mohammed,Andrew Butler,John Klinck,Christopher Watson

{"title":"Normothermic regional and ex-situ perfusion reduces Postreperfusion syndrome in donation after circulatory death liver transplantation: a retrospective comparative study.","authors":"Anand Puttappa,Rohit Gaurav,Vibhay Kakhandki,Lisa Swift,Corrina Fear,Rachel Webster,Ahmed Radwan,Musab Mohammed,Andrew Butler,John Klinck,Christopher Watson","doi":"10.1016/j.ajt.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.01.007","url":null,"abstract":"In controlled donation after circulatory death (DCD) liver transplantation, ischemia-reperfusion injury is linked to post-reperfusion syndrome (PRS), acute kidney injury (AKI), and early allograft dysfunction (EAD). Normothermic regional perfusion (NRP) and normothermic machine perfusion (NMP) are techniques that mitigate ischemic injury and associated complications. In this single centre retrospective study, we compared early transplant outcomes of DCD livers undergoing direct procurement (DP) and static cold storage (DCD-DP-SCS), NRP procurement with SCS (DCD-NRP-SCS), or DP with NMP (DCD-DP-NMP). Two hundred and thirty-eight DCD liver recipients were evaluated, comprising 59 DCD-DP-SCS, 101 DCD-NRP-SCS, and 78 DCD-DP-NMP. Overall, the PRS incidence was 19%. DCD-DP-SCS had higher incidence of PRS (37%; P<0.001), AKI stage≥2 (47%; P=0.033), and increased Model for Early Allograft Function (MEAF) score (p<0.001). In adjusted multivariate analysis, recipient age (OR 1.10, 95%CI 1.05-1.17; P<0.001), and normothermic perfusion (DCD-NRP-SCS OR 0.16, 95%CI 0.06-0.39; P<0.001; DCD-DP-NMP OR 0.38, 95%CI 0.15-0.91; P=0.032) were significant predictors of PRS, which itself was associated with worse 5-year transplant survival (graft survival non-censored-to-death; HR 2.9, 95%CI 1.3-6.7; P=0.012). Compared to static cold storage alone, use of either NRP or NMP significantly reduced the incidence of PRS and AKI with better early graft function.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"46 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Everolimus Combination Therapy and Cancer Risk after Liver Transplantation: A Nationwide Population-based Quasi-Cohort Study. 依维莫司联合治疗与肝移植后癌症风险的关系：一项全国性的准队列研究。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-01-16 DOI: 10.1016/j.ajt.2025.01.005

Suk-Chan Jang,Gi-Ae Kim,Young-Suk Lim,Hye-Lin Kim,Eui-Kyung Lee

{"title":"Association between Everolimus Combination Therapy and Cancer Risk after Liver Transplantation: A Nationwide Population-based Quasi-Cohort Study.","authors":"Suk-Chan Jang,Gi-Ae Kim,Young-Suk Lim,Hye-Lin Kim,Eui-Kyung Lee","doi":"10.1016/j.ajt.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.01.005","url":null,"abstract":"The potential of everolimus in reducing hepatocellular carcinoma (HCC) among recipients following liver transplantation has been reported. This nationwide population-based quasi-cohort study investigated whether combining everolimus with calcineurin inhibitor therapy affects the risk of HCC and extrahepatic cancers compared to a time-duration-matched cohort of recipients not receiving everolimus. Using data covering the entire population from Korea, liver transplant recipients who had initiated immunosuppressants between June 2015 and February 2020 were collected and divided into two groups: the everolimus combination and non-combination groups. We calculated adjusted hazard ratios (aHRs) and absolute risk reduction (ARR) for the risk of HCC and extrahepatic cancer with everolimus combination therapy using a Cox regression model. A time-duration-matched retrospective cohort of 932 recipients in both of the groups was identified. The everolimus combination group showed a lower risk of HCC (aHR, 0.53; 95% confidence interval [CI] 0.30-0.94) and extrahepatic cancers (aHR, 0.30; 95% CI 0.14-0.63) compared to the non-combination group. The ARR was 0.004 for HCC and 0.012 for extrahepatic cancer. The findings suggest that adding everolimus to calcineurin inhibitor therapy reduces cancer risk in liver transplant recipients, highlighting the importance of considering cancer risk when choosing immunosuppressive therapies.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"32 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finding Actionable Information in the Unvierse of Data. 在数据宇宙中寻找可操作的信息。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-01-15 DOI: 10.1016/j.ajt.2025.01.004

Jennifer Gaganon,Lisa M McElroy

引用次数: 0

Influenza A(H5N1) Virus Clade 2.3.2.1a in Traveler Returning to Australia from India, 2024. 2024年从印度返回澳大利亚的旅行者携带的甲型H5N1病毒进化支2.3.2.1a。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-15 DOI: 10.1016/j.ajt.2025.01.003

Marcus Pereira

引用次数: 0

From Hero to Zero: A Single Center Retrospective Review of the Utility of Routine Physical Crossmatching. 从英雄到零：常规物理交叉匹配效用的单中心回顾。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-01-13 DOI: 10.1016/j.ajt.2025.01.010

Robert Achram,Anna Morris,Lalit Patel,Robert Bray,Howard Gebel,H Cliff Sullivan

{"title":"From Hero to Zero: A Single Center Retrospective Review of the Utility of Routine Physical Crossmatching.","authors":"Robert Achram,Anna Morris,Lalit Patel,Robert Bray,Howard Gebel,H Cliff Sullivan","doi":"10.1016/j.ajt.2025.01.010","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.01.010","url":null,"abstract":"Pre-transplantation HLA antibody testing is necessary to assess compatibility between donor and recipient pairs. Over the past decade, the virtual crossmatch (VXM) has replaced the physical crossmatch (PXM) as the main assessment of pre-transplant histocompatibility. At our center, most transplants have proceeded based solely on the VXM, followed by a retrospective PXM. In this study, we sought to determine whether VXMs alone are sufficient and if routine retrospective PXMs can be discontinued. A review of PXMs for single solid organ transplant cases between 5/19/2020 and 12/9/2022 was performed to examine the concordance between the PXM and VXM (including predictions of the PXM made in the VXM report). The relationship between PXM results (PXMR) and donor specific antibody (DSA) mean fluorescence intensity (MFI) values was also examined. The overall PXM prediction/PXM result concordance rate was 99.7% based on PXMs attributed to HLA antibody. Furthermore, DSA MFI values can guide clinical decisions on whether to perform a PXM. The data confirm that, in the era of the VXM, routine PXMs performed for all transplants are not warranted. However, a PXM may still be informative in select cases where low-to-intermediate strength DSAs are present or when the virtual assessment is ambiguous.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"72 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A trip down (obesogenic) memory lane. 一次（致肥）记忆之旅。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-11 DOI: 10.1016/j.ajt.2025.01.009

Sarah Alshammery, Natasha M Rogers

引用次数: 0

Out-of-sequence allocation: It is useful, but is it ethical? 非顺序分配：有用，但道德吗？

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-10 DOI: 10.1016/j.ajt.2025.01.008

Lara C Pullen

引用次数: 0

Treatment of rapid recurrence of severe steatosis with combined GLP-1 agonist and growth hormone therapy in a pediatric patient transplanted for metabolic dysfunction-associated steatohepatitis cirrhosis in the setting of hypopituitarism. GLP-1激动剂和生长激素联合治疗1例垂体功能低下的儿童代谢功能障碍相关脂肪性肝炎肝硬化移植患者中严重脂肪变性的快速复发

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-08 DOI: 10.1016/j.ajt.2025.01.002

Stephanie R Saaybi, Henry Shiau, Goo Lee, Babak John Orandi, Luz Helena Gutierrez Sanchez

{"title":"Treatment of rapid recurrence of severe steatosis with combined GLP-1 agonist and growth hormone therapy in a pediatric patient transplanted for metabolic dysfunction-associated steatohepatitis cirrhosis in the setting of hypopituitarism.","authors":"Stephanie R Saaybi, Henry Shiau, Goo Lee, Babak John Orandi, Luz Helena Gutierrez Sanchez","doi":"10.1016/j.ajt.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.01.002","url":null,"abstract":"<p><p>The association between hypopituitarism and metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized, although data about therapies targeting recurrence post-transplant is limited. An 8-year-old with hypopituitarism-associated MASLD underwent a liver transplant due to rapid progression of metabolic dysfunction-associated steatohepatitis (MASH). Hepatosteatosis recurred within weeks. Her therapeutic plan included a glucagon-like peptide-1 agonist (GLP-1a) and growth hormone replacement. Her transaminases normalized in 2.5 months, and her macrosteatosis significantly improved on the one-year surveillance biopsy. This case highlights one of the youngest reported patients with hypopituitarism to have undergone transplantation for rapidly progressing MASH and its recurrence post-operatively. We observed that steatosis improved with growth hormone replacement and GLP-1a therapy. If started early, this combination could help delay recurrence of steatosis post-transplantation. Further research is needed to determine long-term effects and establish protocols.</p>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning for personalized and prediction of longitudinal COVID-19 vaccine responses in transplant recipients. 用于个性化和预测移植受者COVID-19纵向疫苗反应的机器学习。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-01-08 DOI: 10.1016/j.ajt.2025.01.001

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0