American Journal of Transplantation最新文献_第2页

Carbapenem-resistant Enterobacterales in solid organ transplant recipients. 实体器官移植受者中的耐碳青霉烯类肠杆菌。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-08 DOI: 10.1016/j.ajt.2024.10.020

Angelique E Boutzoukas, Weixiao Dai, Eric Cober, Lilian M Abbo, Lauren Komarow, Liang Chen, Carol Hill, Michael J Satlin, Matthew Grant, Bettina C Fries, Gopi Patel, Todd P McCarty, Cesar A Arias, Robert A Bonomo, David van Duin

{"title":"Carbapenem-resistant Enterobacterales in solid organ transplant recipients.","authors":"Angelique E Boutzoukas, Weixiao Dai, Eric Cober, Lilian M Abbo, Lauren Komarow, Liang Chen, Carol Hill, Michael J Satlin, Matthew Grant, Bettina C Fries, Gopi Patel, Todd P McCarty, Cesar A Arias, Robert A Bonomo, David van Duin","doi":"10.1016/j.ajt.2024.10.020","DOIUrl":"10.1016/j.ajt.2024.10.020","url":null,"abstract":"Carbapenem-resistant Enterobacterales (CRE) are an important threat to the health of solid organ transplant recipients (SOTr); data comparing outcomes of SOTr with CRE to non-SOTr with CRE are lacking. A matched cohort study was performed within two prospective, multicenter, cohort studies (CRACKLE, CRACKLE-2). The epidemiology, desirability of outcome rankings (DOOR) outcomes, and mortality of SOTr and non-SOTr hospitalized in the United States (December 2011 - August 2017) with clinical isolates with Centers for Disease Control and Prevention-defined CRE were compared. In total, 121 SOTr and 242 matched non-SOTr were included. Fifty one percent of isolates met infection criteria. SOTr were younger (p<0.001), less acutely ill (p=0.029), less often had a malignancy history (p=0.006), and more often were admitted from home (p<0.001) than non-SOTr. SOTr had more favorable adjusted DOOR outcomes; a randomly selected SOTr had a 58% (95% CI 53%-64%) probability of a better outcome as compared to a randomly selected non-SOTr. All-cause 30-day mortality was 14% (17/121) in SOTr vs. 25% (60/242) in non-SOTr, p=0.018. After stabilized inverse-probability weighted adjustment, SOTr had a 7% lower 30-d mortality risk than non-SOTr (95% CI -15%, 1%). SOTr with CRE do not have worse outcomes than matched patients without transplant history.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keep the Engine Running Maintaining Transplant Registry Utility in Liver Transplant. 保持引擎运转，维护肝移植注册中心的实用性。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-07 DOI: 10.1016/j.ajt.2024.11.001

Steven A Wisel, Justin A Steggerda, Aleah L Brubaker, Anji Wall, Irene K Kim

引用次数: 0

Severe ischemia and reperfusion injury induces epigenetic inactivation of LHX1 in kidney progenitor cells after kidney transplantation. 肾移植后严重缺血和再灌注损伤会诱导肾脏祖细胞中 LHX1 的表观遗传失活。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-07 DOI: 10.1016/j.ajt.2024.11.003

Josep M Cruzado, Anna Sola, Miguel L Pato, Anna Manonelles, Cristian Varela, Fernando E Setién, Carlos Quero, James S Heald, David Piñeyro, Ana Amaya-Garrido, Núria Doladé, Sergi Codina, Carlos Couceiro, Núria Bolaños, Montserrat Gomà, Francesc Vigués, Angelika Merkel, María Berdasco

{"title":"Severe ischemia and reperfusion injury induces epigenetic inactivation of LHX1 in kidney progenitor cells after kidney transplantation.","authors":"Josep M Cruzado, Anna Sola, Miguel L Pato, Anna Manonelles, Cristian Varela, Fernando E Setién, Carlos Quero, James S Heald, David Piñeyro, Ana Amaya-Garrido, Núria Doladé, Sergi Codina, Carlos Couceiro, Núria Bolaños, Montserrat Gomà, Francesc Vigués, Angelika Merkel, María Berdasco","doi":"10.1016/j.ajt.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.ajt.2024.11.003","url":null,"abstract":"Severe ischemia-reperfusion injury (IRI) causes acute and chronic kidney allograft damage. As therapeutic interventions to reduce damage are limited yet, research on how to promote kidney repair has gained significant interest. To address this question, we performed genome-wide transcriptome and epigenome profiling in progenitor cells isolated from urine of deceased (severe IRI) and living (mild IRI) donor human kidney transplants and identified LIM homebox-1 (LHX1) as an epigenetically regulated gene whose expression depends on the IRI severity. Using a mice model of IRI, we observed a relationship between IRI severity, LHX1 promoter hypermethylation and LHX1 gene expression. By functional studies we confirmed that LHX1 expression is involved in proliferation of epithelial tubular cells and podocyte differentiation from kidney progenitor cells. Our results provide evidence that severe IRI may reduce intrinsic mechanisms of kidney repair through epigenetic signaling.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Outcomes of Induction Immunosuppression for Kidney Transplant Recipients With HIV Who Have Average Immunologic Risk: An Inverse Probability Treatment Weighting Analysis. 免疫风险一般的 HIV 肾移植受者接受诱导免疫抑制的长期疗效：反概率治疗加权分析。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-06 DOI: 10.1016/j.ajt.2024.11.004

Rasha El Rifai, Kaushik Bhunia, Lauren Fontana, Kurtis J Swanson, Scott Jackson, Byron H Smith, Samy M Riad

{"title":"Long-Term Outcomes of Induction Immunosuppression for Kidney Transplant Recipients With HIV Who Have Average Immunologic Risk: An Inverse Probability Treatment Weighting Analysis.","authors":"Rasha El Rifai, Kaushik Bhunia, Lauren Fontana, Kurtis J Swanson, Scott Jackson, Byron H Smith, Samy M Riad","doi":"10.1016/j.ajt.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.ajt.2024.11.004","url":null,"abstract":"We analyzed the Scientific Registry of Transplant Recipients (2004-2022) for primary kidney recipients with HIV who had average immunologic risk and were discharged on tacrolimus/mycophenolate mofetil (with or without corticosteroids). Recipients were grouped by induction type: rabbit antithymocyte globulin (r-ATG, n=688) and human interleukin-2 receptor antagonist (IL2Ra, n=467). Kaplan-Meier curves were generated to examine recipient and graft survival by induction type. We used mixed Cox proportional hazard models to determine associations between induction type and outcomes of interest, with adjustments for recipient and donor factors and transplant center as a random effect. Regression with propensity score weighting reduced selection bias from nonrandom induction allocation. The unadjusted 10-year survival rate was 57% for those receiving r-ATG and 64% for those receiving IL2Ra (P<.001). Adjusted risk of death was significantly lower for IL2Ra induction than r-ATG induction with Cox multivariable (hazard ratio, 0.65; 95% CI, 0.47-0.91; P=.01) and inverse probability treatment weighting (hazard ratio, 0.38; 95% CI, 0.29-0.50; P<.01) models. Death-censored kidney graft survival did not differ by induction type in either model. The 1-year rejection rate was 10.1% and 11.6% for r-ATG and IL2Ra recipients, respectively (P=.52). Overall, IL2Ra conferred better long-term survival than r-ATG without increased risk of graft loss.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical outcomes of pediatric kidney replacement therapy after childhood cancer - ESPN/ERA Registry study. 儿童癌症后小儿肾脏替代治疗的临床结果 - ESPN/ERA 登记研究。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-06 DOI: 10.1016/j.ajt.2024.11.002

Henna Kaijansinkko, Marjolein Bonthuis, Kirsi Jahnukainen, Jerome Harambat, Enrico Vidal, Sevcan A Bakkaloglu, Carol Inward, Manish D Sinha, Rosa M Roperto, Claudia E Kuehni, Erika Biró, Theresa Kwon, Conceição Mota, Brigitte Adams, Maria Szczepańska, Beata Bieniaś, Britta Höcker, Svitlana Fomina, Ann Christin Gjerstad, Karel Vondrak, Harika Alpay, Lucy A Plumb, Kristine Hommel, Maria S Molchanova, Holger Hubmann, Angel Alonso-Melgar, Kitty J Jager, Timo Jahnukainen

{"title":"Clinical outcomes of pediatric kidney replacement therapy after childhood cancer - ESPN/ERA Registry study.","authors":"Henna Kaijansinkko, Marjolein Bonthuis, Kirsi Jahnukainen, Jerome Harambat, Enrico Vidal, Sevcan A Bakkaloglu, Carol Inward, Manish D Sinha, Rosa M Roperto, Claudia E Kuehni, Erika Biró, Theresa Kwon, Conceição Mota, Brigitte Adams, Maria Szczepańska, Beata Bieniaś, Britta Höcker, Svitlana Fomina, Ann Christin Gjerstad, Karel Vondrak, Harika Alpay, Lucy A Plumb, Kristine Hommel, Maria S Molchanova, Holger Hubmann, Angel Alonso-Melgar, Kitty J Jager, Timo Jahnukainen","doi":"10.1016/j.ajt.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.ajt.2024.11.002","url":null,"abstract":"Cancer and its treatment may lead to kidney injury and need for kidney replacement therapy (KRT). We identified 287 pediatric KRT patients with a malignancy history from the ESPN/ERA Registry. Of these, 197 had cancer as a primary cause of KRT (group 1) and 90 had a malignancy diagnosis before KRT (group 2). Two matched controls without malignancy were randomly selected for each patient. Data were complemented with a questionnaire. Median time to kidney transplantation (KT) from KRT initiation was 2.4 (IQR: 1.5-4.7), 1.5 (IQR: 0.4-3.3), 3.6 (IQR: 1.3-Q3 not reached), and 1.1 (IQR: 0.3-3.6) years for group 1, their controls, group 2 and their controls, respectively. Overall 10-year mortality on KRT was higher among cancer patients vs. controls in group 1: 16% vs. 9% (aHR 2.02, 95% CI: 1.21-3.37) and in group 2: 23% vs. 14% (aHR 2.32, 95% CI: 1.11-4.85). In contrast, 10-year patient survival after first KT was comparable to controls (93% vs. 96%; 100% vs. 94%, in groups 1 and 2, respectively). In summary, childhood cancer survivors' KT was delayed, their overall mortality on KRT was increased, but once transplanted, their long-term outcome was similar to other KT recipients.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation [American Journal of Transplantation 24 (2024) 1247-1256]. 对《胰肾同步移植中循环死亡后供体死亡时间对受体预后的影响》的勘误 [American Journal of Transplantation 24 (2024) 1247-1256]。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-06 DOI: 10.1016/j.ajt.2024.10.017

Abdullah K Malik, Samuel J Tingle, Nicholas Chung, Ruth Owen, Balaji Mahendran, Claire Counter, Sanjay Sinha, Anand Muthasamy, Andrew Sutherland, John Casey, Martin Drage, David van Dellen, Chris J Callaghan, Doruk Elker, Derek M Manas, Gavin J Pettigrew, Colin H Wilson, Steven A White

引用次数: 0

Effect of mitochondrial oxidative stress on Regulatory T Cell manufacturing for clinical application in transplantation: results from a pilot study. 线粒体氧化应激对用于临床移植的调节性 T 细胞制造的影响：一项试点研究的结果。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-06 DOI: 10.1016/j.ajt.2024.10.024

Roberto Gedaly, Gabriel Orozco, Lillie J Lewis, Deepa Valvi, Fanny Chapelin, Aman Khurana, Giovanna E Hidalgo, Aaron Shmookler, Aashutosh Tripathi, Cuiping Zhang, Joseph B Zwischenberger, Francesc Marti

{"title":"Effect of mitochondrial oxidative stress on Regulatory T Cell manufacturing for clinical application in transplantation: results from a pilot study.","authors":"Roberto Gedaly, Gabriel Orozco, Lillie J Lewis, Deepa Valvi, Fanny Chapelin, Aman Khurana, Giovanna E Hidalgo, Aaron Shmookler, Aashutosh Tripathi, Cuiping Zhang, Joseph B Zwischenberger, Francesc Marti","doi":"10.1016/j.ajt.2024.10.024","DOIUrl":"https://doi.org/10.1016/j.ajt.2024.10.024","url":null,"abstract":"The manufacturing process of Regulatory T (Treg) cells for clinical application begins with the positive selection of CD25+ cells using superparamagnetic iron-oxide nanoparticle (SPION)-conjugated anti-CD25 antibodies (spCD25) and immunomagnetic cell separation technology. Our findings revealed that the interaction of spCD25 with its cell target induced the internalization of the complex spCD25-Interleukin-2 Receptor. Accumulation of intracellular spCD25 triggered oxidative stress, causing delayed Treg expansion and temporary reduction in suppressor activity. This activation delay hindered the efficient generation of clinically competent cells. During this early phase, Treg cells exhibited elevated mitochondrial superoxide and lipid peroxidation levels, with concomitant decrease on mitochondrial respiration rates. The results uncovered the increased mitochondrial unfolded protein response (mitoUPR). This protective, redox-sensitive activity is inherent of Tregs when contrasted with homologous, spCD25-treated, conventional T cells. While the temporary effects of spCD25 on clinically competent cells did not impede their use in a safety/feasibility pilot study with kidney transplant recipients*, it is reasonable to anticipate a potential reduction in their therapeutic efficacy. The mechanistic understanding of the adverse effects triggered by spCD25 is crucial for improving the manufacturing process of clinically competent Treg cells, a pivotal step in the successful implementation of immune cell therapy in transplantation. *Clinical trial registration number NCT03284242 at ClinicalTrials.gov.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neoadjuvant Pemigatinib as a Bridge to Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma with FGFR2 Rearrangement. 新辅助佩米加替尼作为FGFR2重排肝内胆管癌活体肝移植的桥梁

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-06 DOI: 10.1016/j.ajt.2024.10.023

Matthew M Byrne, Richard F Dunne, Jennifer I Melaragno, Mariana Chávez-Villa, Aram Hezel, Xiaoyan Liao, Marco Ertreo, Bandar Al-Judaibi, Mark Orloff, Roberto Hernandez-Alejandro, Koji Tomiyama

{"title":"Neoadjuvant Pemigatinib as a Bridge to Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma with FGFR2 Rearrangement.","authors":"Matthew M Byrne, Richard F Dunne, Jennifer I Melaragno, Mariana Chávez-Villa, Aram Hezel, Xiaoyan Liao, Marco Ertreo, Bandar Al-Judaibi, Mark Orloff, Roberto Hernandez-Alejandro, Koji Tomiyama","doi":"10.1016/j.ajt.2024.10.023","DOIUrl":"https://doi.org/10.1016/j.ajt.2024.10.023","url":null,"abstract":"We report a case of a 55-year-old male with intrahepatic cholangiocarcinoma (iCCA) who underwent living donor liver transplantation (LDLT) after complete radiographic response on second line pemigatinib. LDLT for iCCA is controversial, but recent reports have cited the potential benefit for patients with unresectable disease, especially those with disease stability after 6 months of systemic therapy. Concomitantly, genomic profiling has identified potentially treatable oncologic targets in iCCA. This patient's tumor genomic profile revealed a FGFR2 rearrangement and was treated with pemigatinib, a competitive inhibitor for FGFR1/2/3. This resulted in complete radiographic and metabolic response after two months of treatment. He was considered eligible for LDLT after 6 months of observation on treatment with sustained response. He underwent an uncomplicated LDLT (including an uncomplicated donor surgery) and at one year follow-up is without evidence of disease recurrence. We believe this is the first report of LDLT for this indication.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing machine learning models to predict primary graft dysfunction after lung transplantation 开发机器学习模型，预测肺移植后的原发性移植物功能障碍

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2024-03-01 DOI: 10.1016/j.ajt.2023.07.008

Andrew P. Michelson , Inez Oh , Aditi Gupta , Varun Puri , Daniel Kreisel , Andrew E. Gelman , Ruben Nava , Chad A. Witt , Derek E. Byers , Laura Halverson , Rodrigo Vazquez-Guillamet , Philip R.O. Payne , Ramsey R. Hachem

{"title":"Developing machine learning models to predict primary graft dysfunction after lung transplantation","authors":"Andrew P. Michelson , Inez Oh , Aditi Gupta , Varun Puri , Daniel Kreisel , Andrew E. Gelman , Ruben Nava , Chad A. Witt , Derek E. Byers , Laura Halverson , Rodrigo Vazquez-Guillamet , Philip R.O. Payne , Ramsey R. Hachem","doi":"10.1016/j.ajt.2023.07.008","DOIUrl":"10.1016/j.ajt.2023.07.008","url":null,"abstract":"<div>Primary graft dysfunction (PGD) is the leading cause of morbidity and mortality in the first 30 days after lung transplantation. Risk factors for the development of PGD include donor and recipient characteristics, but how multiple variables interact to impact the development of PGD and how clinicians should consider these in making decisions about donor acceptance remain unclear. This was a single-center retrospective cohort study to develop and evaluate machine learning pipelines to predict the development of PGD grade 3 within the first 72 hours of transplantation using donor and recipient variables that are known at the time of donor offer acceptance. Among 576 bilateral lung recipients, 173 (30%) developed PGD grade 3. The cohort underwent a 75% to 25% train-test split, and lasso regression was used to identify 11 variables for model development. A K-nearest neighbor’s model showing the best calibration and performance with relatively small confidence intervals was selected as the final predictive model with an area under the receiver operating characteristics curve of 0.65. Machine learning models can predict the risk for development of PGD grade 3 based on data available at the time of donor offer acceptance. This may improve donor-recipient matching and donor utilization in the future.</div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 3","pages":"Pages 458-467"},"PeriodicalIF":8.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9932147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pure laparoscopic donor hepatectomy: A nearly finished product 纯腹腔镜供体肝切除术：即将完成的产品

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2024-02-01 DOI: 10.1016/j.ajt.2023.08.013

Benjamin Samstein, Daniel Cherqui

引用次数: 0