American Journal of Transplantation最新文献_第3页

Neoadjuvant Pemigatinib as a Bridge to Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma with FGFR2 Rearrangement. 新辅助佩米加替尼作为FGFR2重排肝内胆管癌活体肝移植的桥梁

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-06 DOI: 10.1016/j.ajt.2024.10.023

Matthew M Byrne, Richard F Dunne, Jennifer I Melaragno, Mariana Chávez-Villa, Aram Hezel, Xiaoyan Liao, Marco Ertreo, Bandar Al-Judaibi, Mark Orloff, Roberto Hernandez-Alejandro, Koji Tomiyama

{"title":"Neoadjuvant Pemigatinib as a Bridge to Living Donor Liver Transplantation for Intrahepatic Cholangiocarcinoma with FGFR2 Rearrangement.","authors":"Matthew M Byrne, Richard F Dunne, Jennifer I Melaragno, Mariana Chávez-Villa, Aram Hezel, Xiaoyan Liao, Marco Ertreo, Bandar Al-Judaibi, Mark Orloff, Roberto Hernandez-Alejandro, Koji Tomiyama","doi":"10.1016/j.ajt.2024.10.023","DOIUrl":"https://doi.org/10.1016/j.ajt.2024.10.023","url":null,"abstract":"<p><p>We report a case of a 55-year-old male with intrahepatic cholangiocarcinoma (iCCA) who underwent living donor liver transplantation (LDLT) after complete radiographic response on second line pemigatinib. LDLT for iCCA is controversial, but recent reports have cited the potential benefit for patients with unresectable disease, especially those with disease stability after 6 months of systemic therapy. Concomitantly, genomic profiling has identified potentially treatable oncologic targets in iCCA. This patient's tumor genomic profile revealed a FGFR2 rearrangement and was treated with pemigatinib, a competitive inhibitor for FGFR1/2/3. This resulted in complete radiographic and metabolic response after two months of treatment. He was considered eligible for LDLT after 6 months of observation on treatment with sustained response. He underwent an uncomplicated LDLT (including an uncomplicated donor surgery) and at one year follow-up is without evidence of disease recurrence. We believe this is the first report of LDLT for this indication.</p>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-specific Immune Senescence as a Candidate Biomarker of Operational Tolerance Following Liver Transplantation in Adults: Results of a Prospective, Multicenter Cohort Study. 作为成人肝移植后操作耐受性候选生物标志物的捐献者特异性免疫衰老：一项前瞻性多中心队列研究的结果。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-04 DOI: 10.1016/j.ajt.2024.10.022

Naoki Tanimine, James F Markmann, Michelle A Wood-Trageser, Anthony J Demetris, Kristen Mason, Juliete A F Silva, Josh Levitsky, Sandy Feng, Abhinav Humar, Jean C Emond, Abraham Shaked, Goran Klintmalm, Alberto Sanchez-Fueyo, Drew Lesniak, Cynthia P Breeden, Gerald T Nepom, Nancy D Bridges, Julia Goldstein, Christian P Larsen, Michele DesMarais, Geo Gaile, Sindhu Chandran

{"title":"Donor-specific Immune Senescence as a Candidate Biomarker of Operational Tolerance Following Liver Transplantation in Adults: Results of a Prospective, Multicenter Cohort Study.","authors":"Naoki Tanimine, James F Markmann, Michelle A Wood-Trageser, Anthony J Demetris, Kristen Mason, Juliete A F Silva, Josh Levitsky, Sandy Feng, Abhinav Humar, Jean C Emond, Abraham Shaked, Goran Klintmalm, Alberto Sanchez-Fueyo, Drew Lesniak, Cynthia P Breeden, Gerald T Nepom, Nancy D Bridges, Julia Goldstein, Christian P Larsen, Michele DesMarais, Geo Gaile, Sindhu Chandran","doi":"10.1016/j.ajt.2024.10.022","DOIUrl":"https://doi.org/10.1016/j.ajt.2024.10.022","url":null,"abstract":"<p><p>Immunosuppression can be withdrawn from selected liver transplant recipients, although robust clinical predictors of tolerance remain elusive. The Immune Tolerance Network ITN056ST study (OPTIMAL) assessed clinical outcomes and mechanistic correlates of phased immunosuppression withdrawal (ISW) in non-autoimmune, non-viral adult liver transplant recipients. Enrolled subjects were ≥3 years post-transplant with minimal/absent inflammation or fibrosis on a screening liver biopsy. The primary endpoint was operational tolerance at 52 weeks following complete ISW. Of 61 subjects who initiated ISW, 34 failed during ISW and 10 restarted immunosuppression due to clinically manifest acute rejection. Of the 17 subjects remaining off immunosuppression at 1 year, 10 were ultimately deemed tolerant by biopsy. There were no cases of chronic rejection or graft loss. The majority of subjects (78.6%), including those who experienced rejection, ended the study on same or less calcineurin inhibitor than at baseline. 28.3% developed de novo DSA during ISW, which persisted in 11.3%. A minority (16.4%) of histologically and clinically stable long-term adult liver transplant recipients can successfully discontinue and remain off immunosuppression. Increased frequency of donor-specific T cell senescence, C4d deposition and higher density of immune synapses on the screening liver biopsy emerged as potential candidate biomarkers for operational tolerance. NCT02533180.</p>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kids are special: Are we giving them the priority they deserve? 孩子是特殊的：我们是否给予了他们应有的优先权？

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.09.019

Lara C. Pullen PhD

引用次数: 0

Corrigendum to ‘Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: A 2-year diagnostic accuracy study of participants from a randomized controlled trial’ [American Journal of Transplantation 22 (2022) 2880-2891] 肾移植后糖尿病前期和移植后糖尿病的标准：随机对照试验参与者的两年诊断准确性研究"[《美国移植杂志》22 (2022)2880-2891] 的更正。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.08.003

Amelie Kurnikowski , Espen Nordheim , Elisabeth Schwaiger , Simon Krenn , Jürgen Harreiter , Alexandra Kautzky-Willer , Michael Leutner , Johannes Werzowa , Andrea Tura , Klemens Budde , Kathrin Eller , Julio Pascual , Michael Krebs , Trond Geir Jenssen , Manfred Hecking

引用次数: 0

Murine orthotopic lung transplant models: A comprehensive overview of genetic mismatch degrees and histopathological insights into chronic lung allograft dysfunction 小鼠正位肺移植模型：遗传错配程度的全面概述和慢性肺移植功能障碍的组织病理学见解。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.033

Axelle Coppens , Stijn E. Verleden , Erik Claes , Hanne Voet , Geert M. Verleden , Therese S. Lapperre , Ali Ö. Yildirim , Wolfgang Jungraithmayr , Yoshito Yamada , Dieter J.E. Peeters , Jeroen M.H. Hendriks

{"title":"Murine orthotopic lung transplant models: A comprehensive overview of genetic mismatch degrees and histopathological insights into chronic lung allograft dysfunction","authors":"Axelle Coppens , Stijn E. Verleden , Erik Claes , Hanne Voet , Geert M. Verleden , Therese S. Lapperre , Ali Ö. Yildirim , Wolfgang Jungraithmayr , Yoshito Yamada , Dieter J.E. Peeters , Jeroen M.H. Hendriks","doi":"10.1016/j.ajt.2024.07.033","DOIUrl":"10.1016/j.ajt.2024.07.033","url":null,"abstract":"<div><div>Currently, lung transplantation outcome remains inferior compared to other solid organ transplantations. A major cause for limited survival after lung transplantation is chronic lung allograft dysfunction. Numerous animal models have been developed to investigate chronic lung allograft dysfunction to discover adequate treatments. The murine orthotopic lung transplant model has been further optimized over the last years. However, different degrees of genetic mismatch between donor and recipient mice have been used, applying a single, minor, moderate, and major genetic mismatch. This review aims to reassess the existing murine mismatch models and provide a comprehensive overview, with a specific focus on their eventual histopathological presentation. This will be crucial to leverage this model and tailor it according to specific research needs.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 1930-1940"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141887620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trained immunity suppression determines kidney allograft survival 训练有素的免疫抑制决定了肾脏异体移植的存活率。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.08.006

Inge Jonkman , Maaike M.E. Jacobs , Yutaka Negishi , Cansu Yanginlar , Joost H.A. Martens , Marijke Baltissen , Michiel Vermeulen , Martijn W.F. van den Hoogen , Marije Baas , Johan van der Vlag , Zahi A. Fayad , Abraham J.P. Teunissen , Joren C. Madsen , Jordi Ochando , Leo A.B. Joosten , Mihai G. Netea , Willem J.M. Mulder , Musa M. Mhlanga , Luuk B. Hilbrands , Nils Rother , Raphaël Duivenvoorden

{"title":"Trained immunity suppression determines kidney allograft survival","authors":"Inge Jonkman , Maaike M.E. Jacobs , Yutaka Negishi , Cansu Yanginlar , Joost H.A. Martens , Marijke Baltissen , Michiel Vermeulen , Martijn W.F. van den Hoogen , Marije Baas , Johan van der Vlag , Zahi A. Fayad , Abraham J.P. Teunissen , Joren C. Madsen , Jordi Ochando , Leo A.B. Joosten , Mihai G. Netea , Willem J.M. Mulder , Musa M. Mhlanga , Luuk B. Hilbrands , Nils Rother , Raphaël Duivenvoorden","doi":"10.1016/j.ajt.2024.08.006","DOIUrl":"10.1016/j.ajt.2024.08.006","url":null,"abstract":"<div><div>The innate immune system plays an essential role in regulating the immune responses to kidney transplantation, but the mechanisms through which innate immune cells influence long-term graft survival are unclear. The current study highlights the vital role of trained immunity in kidney allograft survival. Trained immunity describes the epigenetic and metabolic changes that innate immune cells undergo following an initial stimulus, allowing them have a stronger inflammatory response to subsequent stimuli. We stimulated healthy peripheral blood mononuclear cells with pretransplant and posttransplant serum of kidney transplant patients and immunosuppressive drugs in an in vitro trained immunity assay and measured tumor necrosis factor and interleukin 6 cytokine levels in the supernatant as a readout for trained immunity. We show that the serum of kidney transplant recipients collected 1 week after transplantation can suppress trained immunity. Importantly, we found that kidney transplant recipients whose serum most strongly suppressed trained immunity rarely experienced graft loss. This suppressive effect of posttransplant serum is likely mediated by previously unreported effects of immunosuppressive drugs. Our findings provide mechanistic insights into the role of innate immunity in kidney allograft survival, uncovering trained immunity as a potential therapeutic target for improving graft survival.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 2022-2033"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141986955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-species metabolomic profiling reveals phosphocholine-mediated liver protection from cold and ischemia/reperfusion 跨物种代谢组学分析揭示了磷脂酰胆碱介导的对肝脏的保护，使其免受寒冷和缺血/再灌注的影响。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.05.018

{"title":"Cross-species metabolomic profiling reveals phosphocholine-mediated liver protection from cold and ischemia/reperfusion","authors":"","doi":"10.1016/j.ajt.2024.05.018","DOIUrl":"10.1016/j.ajt.2024.05.018","url":null,"abstract":"<div><div><span><span><span>Cold and ischemia/reperfusion (IR)-associated injuries<span><span> are seemingly inevitable during liver transplantation and </span>hepatectomy. Because </span></span>Syrian hamsters<span> demonstrate intrinsic tolerance to transplantation-like stimuli, cross-species comparative metabolomic<span> analyses were conducted with hamster, rat, and donor liver samples to seek hepatic cold and IR-adaptive mechanisms. Lower hepatic phosphocholine contents were found in recipients with early graft-dysfunction and with virus-caused </span></span></span>cirrhosis<span> or high model for end-stage liver disease scores (≥30). Choline/phosphocholine deficiency in cultured human THLE-2 hepatocytes and animal models weakened hepatocellular cold tolerance and recovery of glutathione<span><span> and ATP production, which was rescued by phosphocholine supplements. Among the </span>biological processes<span> impacted by choline/phosphocholine deficiency, 3 lipid-related metabolic processes were downregulated, whereas phosphocholine elevated the expression of genes in methylation processes. Consistently, in THLE-2, phosphocholine enhanced the overall RNA m</span></span></span></span><sup>6</sup>A methylation, among which the transcript stability of <span><span>fatty acid desaturase</span><em> 6</em></span> (<em>FADS6</em>) was improved. <em>FADS6</em><span><span> functioned as a key phosphocholine effector in the production of polyunsaturated fatty acids, which may facilitate the hepatocellular recovery of energy and redox </span>homeostasis. Thus, our study reveals the choline-phosphocholine metabolism and its downstream </span><em>FADS6</em> functions in hepatic adaptation to cold and IR, which may inspire new strategies to monitor donor liver quality and improve recipient recovery from the liver transplantation process.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 1979-1993"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver transplantation for acute liver failure and acute-on-chronic liver failure 肝移植治疗急性肝衰竭 (ALF) 和急性慢性肝衰竭 (ACLF)。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.012

Anand V. Kulkarni , Thierry Gustot , K. Rajender Reddy

{"title":"Liver transplantation for acute liver failure and acute-on-chronic liver failure","authors":"Anand V. Kulkarni , Thierry Gustot , K. Rajender Reddy","doi":"10.1016/j.ajt.2024.07.012","DOIUrl":"10.1016/j.ajt.2024.07.012","url":null,"abstract":"<div><div>Acute liver failure (ALF) and acute-on-chronic liver (ACLF) are distinct phenotypes of liver failure and, thus, need to be compared and contrasted for appropriate management. There has been a significant improvement in the outcomes of these patients undergoing liver transplantation (LT). Survival post-LT for ALF and ACLF ranges between 90% and 95% and 80% and 90% at 1 year, futility criteria have been described in both ALF and ACLF where organ failures define survival. Plasma exchange and continuous renal replacement therapy may serve as bridging therapies. Identifying the futility of LT is as necessary as the utility of LT in patients with ALF and ACLF. The role of regenerative therapies such as granulocyte colony-stimulating factors in ACLF and hepatocyte and xenotransplantation in both conditions remains uncertain. Measures to increase the donor pool through increasing deceased donor transplants in Asian countries, living donations in Western countries, auxiliary liver transplants, and ABO-incompatible liver transplants are necessary to improve the survival of these patients. In this review, we discuss the similarities and differences in clinical characteristics and the timing and outcomes of LT for ALF and ACLF, briefly highlighting the role of bridging therapies and providing an overview of recent advances in the management of ALF and ACLF.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 1950-1962"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreas transplantation as rescue therapy in a patient with type 1 diabetes and concurrent subcutaneous insulin resistance 将胰腺移植作为 1 型糖尿病并发皮下胰岛素抵抗患者的挽救疗法。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.030

Florian Fueermann , Katharina Heller , Marianne Pavel , Larissa Herbst , Robert Grützmann , Mario Schiffer

引用次数: 0

Establishing targets for goal-directed anesthesia in renal transplantation: A cohort analysis of high-saliency surgical time courses 确定肾移植手术中目标导向麻醉的目标：对高强度手术时间序列的队列分析。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.05.020

{"title":"Establishing targets for goal-directed anesthesia in renal transplantation: A cohort analysis of high-saliency surgical time courses","authors":"","doi":"10.1016/j.ajt.2024.05.020","DOIUrl":"10.1016/j.ajt.2024.05.020","url":null,"abstract":"<div><div>Delayed graft function (DGF) increases morbidity and mortality in kidney transplant recipients. Operative parameters, including hemodynamic manipulation through vasopressors and fluids, can impact perfusion to the newly transplanted kidney and influence DGF incidence. We analyzed intraoperative time-series data in 5-minute intervals from kidney transplant recipient operations (N = 545) in conjunction with pretransplant characteristics and postsurgical outcomes, including DGF incidence, 60-day creatinine, and graft survival. Of the operations, 127 DGF events were captured in our cohort from a single academic transplant center (57/278 donations after brainstem death [DBDs], 65/150 donations after circulatory/cardiac death [DCDs], 5/117 live donations). In multiple regression, postanastomosis hypotension defined as mean arterial pressure (MAP) <75 mmHg was a risk factor for DGF independent of conventional predictors of DGF in DCD and DBD kidneys. DCD recipients with DGF had lower average postanastomosis MAP (DGF: 80.1 ± 8.1 mmHg vs no DGF: 76.4 ± 6.7 mmHg, <em>P</em> = .004). Interaction analysis demonstrated above-average doses of vasopressors and crystalloids were associated with improved outcomes when used at MAPs ≤75 mmHg, but they were associated with increased DGF at MAPs >75 mmHg, suggesting that the incidence of DGF can be highly influenced by intraoperative hemodynamic controls. This analysis of surgical time courses has identified potential new strategies for goal-directed anesthesia in renal transplantation.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 2055-2065"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0