American Journal of Transplantation最新文献_第4页

Racial and ethnic disparities in transplantation: Swimming even further upstream to achieve equity 移植手术中的种族和民族差异：逆流而上，实现公平。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.027

Joel T. Adler , Rachel E. Patzer

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Nonclinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK polyomavirus VP1 针对 BK 多瘤病毒 VP1 的新型人源单克隆中和抗体 MAU868 的非临床和临床特征。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.002

{"title":"Nonclinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK polyomavirus VP1","authors":"","doi":"10.1016/j.ajt.2024.07.002","DOIUrl":"10.1016/j.ajt.2024.07.002","url":null,"abstract":"<div><div>Reactivation of BK polyomavirus (BKPyV) can cause significant kidney and bladder disease in immunocompromised patients. There are currently no effective, BKPyV-specific therapies. MAU868 is a novel, human immunoglobulin (Ig) G1 monoclonal antibody that binds the major capsid protein, VP1, of BKPyV with picomolar affinity, neutralizes infection by the 4 major BKPyV genotypes (EC<sub>50</sub> ranging from 0.009-0.093 μg/mL; EC<sub>90</sub> ranging from 0.102-4.160 μg/mL), and has comparable activity against variants with highly prevalent VP1 polymorphisms. No resistance-associated variants were identified in long-term selection studies, indicating a high in vitro barrier-to-resistance. The high-resolution crystal structure of MAU868 in complex with VP1 pentamer identified 3 key contact residues in VP1 (Y169, R170, and K172). A first-in-human study was conducted to assess the safety, tolerability, and pharmacokinetics of MAU868 following intravenous and subcutaneous administration to healthy adults in a randomized, placebo-controlled, double-blinded, single ascending dose design. MAU868 was safe and well-tolerated. All adverse events were grade 1 and resolved. The pharmacokinetics of MAU868 was typical of a human IgG, with dose-proportional systemic exposure and an elimination half-life ranging between 23 and 30 days. These results demonstrate the potential of MAU868 as a first-in-class therapeutic agent for the treatment or prevention of BKPyV disease.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 1994-2006"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public attitudes to xenotransplantation: A national survey in the United States 公众对异种器官移植的态度：美国全国调查。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.018

Luz A. Padilla , Daniel J. Hurst , Amanda Zink , Brendan Parent , Laura L. Kimberly

{"title":"Public attitudes to xenotransplantation: A national survey in the United States","authors":"Luz A. Padilla , Daniel J. Hurst , Amanda Zink , Brendan Parent , Laura L. Kimberly","doi":"10.1016/j.ajt.2024.07.018","DOIUrl":"10.1016/j.ajt.2024.07.018","url":null,"abstract":"<div><div>Xenotransplantation (XTx) presents a potential clinical alternative to the shortage of human organs for transplantation. Before clinical trials occur in the United States, public assessments are crucial to understand potential barriers to acceptance. The purpose of this study was to explore barriers and identify characteristics associated with attitudes toward XTx. A survey assessing demographic characteristics and attitudes toward XTx was distributed to a nationally representative sample of adults aged ≥18 years in the United States. Regression analysis was employed to identify characteristics associated with attitudes toward XTx. Between May 25 and June 14, 2023, 5008 respondents completed the survey. Importantly, half of the respondents expressed low or no knowledge of either transplantation or XTx. Approximately 40% expressed discomfort with receiving a pig organ for themselves or a loved one. Despite a lack of xenotransplant outcome data, 36% were open to experimental XTx if they needed a transplant. However, 57% rated lack of current evidence of success or fear of complications as top concerns. Regression models consistently associated being younger, female, not needing an organ, or being a member of a racial minority group with lower acceptance. This survey is the largest to date exploring public attitudes toward XTx. Despite overall acceptance, concerns persist. Increasing public acceptance is key as the field advances.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 2066-2079"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141755885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updated seasonal influenza and respiratory syncytial virus vaccine recommendations of the Advisory Committee on Immunization Practices - 2024 免疫实践咨询委员会更新的季节性流感和 RSV 疫苗建议 - 2024 年。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.09.001

Marcus R. Pereira

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Letter to the editor: Addressing oncological surveillance in gender-affirming care for transgender and gender diverse liver transplant patients 致编辑的信：在变性和性别多元化肝移植患者的性别确认护理中解决肿瘤监测问题。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.006

引用次数: 0

Partial bladder transplantation with en bloc kidney transplant—long-term, 17 years, the outcome of a “bladder patch technique” 膀胱部分移植与整体肾移植--"膀胱补片技术 "17 年的长期疗效。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.007

Yoko Shirai , Kenichiro Miura , Mari Suzuki , Ikumi Moriyama , Maki Yoshino , Toshio Takagi , Tomoaki Kato , Motoshi Hattori

{"title":"Partial bladder transplantation with en bloc kidney transplant—long-term, 17 years, the outcome of a “bladder patch technique”","authors":"Yoko Shirai , Kenichiro Miura , Mari Suzuki , Ikumi Moriyama , Maki Yoshino , Toshio Takagi , Tomoaki Kato , Motoshi Hattori","doi":"10.1016/j.ajt.2024.07.007","DOIUrl":"10.1016/j.ajt.2024.07.007","url":null,"abstract":"<div><div>A transplant of a portion of the bladder with an en bloc kidney from a 2-year-old donor was previously reported in a 12-month-old girl due to her extremely small bladder. Bilateral kidneys were transplanted en bloc with their ureters connected to a patch of the donor bladder (bladder patch technique). The long-term outcomes and complications of this technique have not been documented. Here, we report a long-term, 17-year follow-up of this patient with an evaluation of whole bladder functions at 18 years of age. The patient has had no episodes of urinary tract infections. Cystoscopy showed a viable transplanted bladder with a well-perfused mucosa. We observed that the native bladder has stretched over time, forming more than half of the bladder wall. Urodynamic studies showed preserved bladder compliance at 43 mL/cmH<sub>2</sub>O, and native bladder contractility was preserved. Prolonged voiding time and postvoid residual urine were also observed. These findings were suggestive of detrusor underactivity. No reﬂux across the donor ureterovesical junctions was observed. The recipient was instructed to continue timed voiding and double voiding to empty the bladder. In conclusion, en bloc kidney transplantation with a bladder patch is a feasible and safe option for kidney transplant recipients with a small bladder capacity.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 2121-2124"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living donor liver transplant in Colombia, with a proposal to reduce geographic disparity in Latin America 哥伦比亚的活体肝移植，建议缩小拉丁美洲的地域差距。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.022

Andres Gomez-Aldana, Rosselli Diego

引用次数: 0

Why partial heart transplantation could be regulated as organ transplantation 为什么可以将部分心脏移植作为器官移植来管理。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.06.003

{"title":"Why partial heart transplantation could be regulated as organ transplantation","authors":"","doi":"10.1016/j.ajt.2024.06.003","DOIUrl":"10.1016/j.ajt.2024.06.003","url":null,"abstract":"<div><div>Partial heart transplant (PHT) is a recent clinical innovation involving the transplantation of a segment of the heart (valves) directly from the deceased donor into the recipient patient. This procedure holds out the possibility of significant benefit, especially for pediatric patients because these grafts show growth potential after transplant, reducing or eliminating the current need for repeat procedures. The clinical process for donation and transplant of partial heart (PH) grafts generally follows an organ clinical pathway; however, the Food and Drug Administration has recently stated its intent to regulate PH as tissues, raising a host of regulatory considerations. PHT requires donor testing and eligibility determinations within a short, clinically viable timeframe and, similar to organ transplant, involves donor-recipient matching. Waitlist allocation policies that are a regulatory focus of the Organ Procurement and Transplantation Network including equity and efficiency may become relevant. Oversight of PHT by the Organ Procurement and Transplantation Network could be accomplished through interpretation of the vascular composite allograft definition or through designation by the US Department of Health and Human Services of PH grafts as organs. While some clinical questions remain unanswered, it is important to carefully address these regulatory considerations to support the emergence of this innovation and ensure the continued trust of the donating public and the patients who may benefit from PHT.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 1941-1949"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organ Procurement Organization-level variation in A1/A2 subtyping of deceased donors 已故捐献者 A1/A2 亚型的 OPO 水平差异。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.008

Shivani S. Bisen , Laura B. Zeiser , Darren E. Stewart , Bonnie E. Lonze , Dorry L. Segev , Allan B. Massie

引用次数: 0

Clinical and molecular spectrum of v-lesion V 形细胞瘤的临床和分子谱。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2024-11-01 DOI: 10.1016/j.ajt.2024.07.025

Anna Buxeda , Marta Crespo , Betty Chamoun , Javier Gimeno , Irina B. Torres , Dolores Redondo-Pachón , Marta Riera , Carla Burballa , Julio Pascual , Michael Mengel , Benjamin A. Adam , María José Pérez-Sáez

{"title":"Clinical and molecular spectrum of v-lesion","authors":"Anna Buxeda , Marta Crespo , Betty Chamoun , Javier Gimeno , Irina B. Torres , Dolores Redondo-Pachón , Marta Riera , Carla Burballa , Julio Pascual , Michael Mengel , Benjamin A. Adam , María José Pérez-Sáez","doi":"10.1016/j.ajt.2024.07.025","DOIUrl":"10.1016/j.ajt.2024.07.025","url":null,"abstract":"<div><div>Isolated v-lesion presents diagnostic stratification and clinical challenges. We characterized allograft outcomes for this entity based on posttransplant time (early: ≤1 month vs late: >1 month) and compared its molecular phenotype with other v+ rejection forms. Using the NanoString B-HOT panel, we analyzed 92 archival formalin-fixed paraffin-embedded tissue kidney biopsies from 3 centers: isolated v-lesion (n = 23), antibody-mediated rejection (ABMR) v+ (n = 26), T cell–mediated rejection (TCMR) v+ (n = 10), mixed rejection v+ (n = 23), and normal tissue (n = 10). Six gene sets (ABMR, DSAST, ENDAT, TCMR, early/acute injury, late injury) were assessed. Early isolated v-lesions had the poorest 1-year death-censored graft survival compared with late isolated v-lesions or other rejections (<em>P</em> = .034). Gene set analysis showed lower TCMR-related gene expression in isolated v+ groups than TCMR and mixed rejection (<em>P</em> < .001). Both early- and late isolated v-lesions had lower ABMR-related gene expression than ABMR, mixed rejection, and TCMR (<em>P</em> ≤ .022). Late isolated v-lesions showed reduced DSAST and ENDAT gene expression versus ABMR (<em>P</em> ≤ .046) and decreased early/acute injury gene expression than early isolated v+, ABMR, TCMR, and mixed rejection (<em>P</em> ≤ .026). In conclusion, isolated v-lesions exhibit distinct gene expression patterns versus other rejection v+ forms. Early isolated v+ is associated with poorer prognosis and increased early/acute injury gene expression than late isolated v+, suggesting distinct etiologies.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"24 11","pages":"Pages 2007-2021"},"PeriodicalIF":8.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0