American Journal of Transplantation最新文献_第5页

Comment on "A comparative study of once-daily vs twice-daily tacrolimus in deceased donor kidney transplant recipients: a national cohort analysis". 对“他克莫司每日一次与每日两次用于已故供体肾移植受者的比较研究：一项国家队列分析”的评论。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-30 DOI: 10.1016/j.ajt.2026.09.037

Basavaraj Poojar

引用次数: 0

Comment on "Effectiveness of respiratory syncytial virus vaccination in solid organ transplant recipients in the United States". 评论“美国实体器官移植受者呼吸道合胞病毒疫苗接种的有效性”。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-29 DOI: 10.1016/j.ajt.2026.09.036

Negar Aliabadi, Caihua Liang, Elizabeth Begier

引用次数: 0

Outcomes After Living Donor Liver Transplant for Intrahepatic Cholangiocarcinoma. 活体肝移植治疗肝内胆管癌的疗效。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-29 DOI: 10.1016/j.ajt.2026.09.039

Vrishketan Sethi, Vikraman Gunabushanam, Hao Liu, Soumik Purkayastha, Elissa Bardhi, David Geller, Swaytha Ganesh, Christopher Hughes, Abhinav Humar

{"title":"Outcomes After Living Donor Liver Transplant for Intrahepatic Cholangiocarcinoma.","authors":"Vrishketan Sethi, Vikraman Gunabushanam, Hao Liu, Soumik Purkayastha, Elissa Bardhi, David Geller, Swaytha Ganesh, Christopher Hughes, Abhinav Humar","doi":"10.1016/j.ajt.2026.09.039","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.09.039","url":null,"abstract":"Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver cancer with limited curative options. Deceased donor liver transplant is associated with survival benefit in select patients with unresectable iCCA, although outcomes are limited by high waitlist mortality and use of expanded criteria grafts, given ongoing deceased donor scarcity. This retrospective, single-center study investigated outcomes for seven patients who underwent living donor liver transplant (LDLT) for unresectable but liver-confined iCCA, managed under a transplant oncology protocol. The patients were selected for disease stability and otherwise met criteria for liver transplant. Six patients received pre-transplant systemic chemotherapy and four underwent locoregional therapy. Median listing Model for End-Stage Liver Disease score was 8 (IQR, 8-11) and patients spent a median 38 days (IQR, 15-70) on waitlist. Two patients experienced Clavien-Dindo grade III complications in the first six months. During a median follow-up of 5.1 years (IQR, 2.8-5.2), two patients experienced recurrence, and one died. 5-year Kaplan-Meier estimates for overall and recurrence-free survival were 85.7% (95% CI, 33.4-97.9) and 71.4% (95% CI, 25.8-92.0), respectively. All donors were alive at last follow-up. For selected patients with unresectable iCCA, LDLT may serve as a useful modality to provide oncological benefit in the era of deceased donor liver scarcity.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular remodeling in obliterative bronchiolitis: A ruthless opportunist or an innocent bystander? 闭塞性细支气管炎的血管重构：无情的投机者还是无辜的旁观者？

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-29 DOI: 10.1016/j.ajt.2026.09.038

Ruben Nava, Benjamin J Kopecky

引用次数: 0

Real-World Evaluation of Recombinant Zoster Vaccine Uptake and Outcomes in Solid Organ Transplant Recipients: A Retrospective Cohort Study. 实体器官移植受者重组带状疱疹疫苗摄取和结果的真实世界评估：一项回顾性队列研究。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-28 DOI: 10.1016/j.ajt.2026.09.033

Sara R Rendell, Kelly Farrell, David J Regan, Rie Maurer, Stefan G Tullius, Jamil R Azzi, Nahel Elias, Leonardo V Riella, Anna E Rutherford, Shimul A Shah, Emily D Bethea, Antonio Coppolino, Nathaniel B Langer, Brian C Keller, Eriberto Michel, Gregory D Lewis, Akinobu Itoh, Michael M Givertz, Linda Irwin, Ruanne V Barnabas, Lindsey R Baden, Ann E Woolley

{"title":"Real-World Evaluation of Recombinant Zoster Vaccine Uptake and Outcomes in Solid Organ Transplant Recipients: A Retrospective Cohort Study.","authors":"Sara R Rendell, Kelly Farrell, David J Regan, Rie Maurer, Stefan G Tullius, Jamil R Azzi, Nahel Elias, Leonardo V Riella, Anna E Rutherford, Shimul A Shah, Emily D Bethea, Antonio Coppolino, Nathaniel B Langer, Brian C Keller, Eriberto Michel, Gregory D Lewis, Akinobu Itoh, Michael M Givertz, Linda Irwin, Ruanne V Barnabas, Lindsey R Baden, Ann E Woolley","doi":"10.1016/j.ajt.2026.09.033","DOIUrl":"10.1016/j.ajt.2026.09.033","url":null,"abstract":"Herpes zoster incidence is increased after solid organ transplantation. We analyzed adult recipients of liver, heart, lung, kidney, pancreas or dual-organ transplants between January 2018 and December 2025. We assessed recombinant zoster vaccine uptake and the association between pre-transplant vaccination and post-transplant herpes zoster in 2595 patients. Median follow-up was 2.8 years [IQR 1.6-4.8]. Thirty-two percent of patients completed the two-dose recombinant zoster vaccine series before transplant. A total of 110 herpes zoster cases occurred. By vaccine status, incidence rates (per 1,000 person-years) were 15.4 [95%CI 12.1-19.5] in unvaccinated pre-transplant, 12.3 [95%CI 7.4-19.2] in those with one dose pre-transplant, and 8.1 [95%CI 4.9-12.7] in those with >2 doses pre-transplant. Among patients who received any post-transplant dose, 83% of herpes zoster cases occurred before vaccination. Compared with under-vaccinated patients, those who completed >2 pre-transplant doses had a 49% lower rate of herpes zoster in the post-transplant period (unadjusted HR=0.51 (0.31-0.85) p=0.009) and a 52% lower adjusted hazard in multivariable analysis (aHR 0.48 95% CI 0.29-0.81, p=0.006). Twenty-four cases of postherpetic neuralgia occurred, none in the fully vaccinated group. Recombinant zoster vaccine uptake remains suboptimal and pre-transplant series completion was associated with lower post-transplant herpes zoster incidence.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Comment on "Beyond theory and into practice: A qualitative study of the experiences of xenotransplant recipients". 回复“超越理论进入实践：异种移植受者经验的定性研究”评论。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-24 DOI: 10.1016/j.ajt.2026.09.029

Macey L Levan, Rhiannon D Reed

引用次数: 0

Comment on "A comparative study of once-daily versus twice-daily tacrolimus in deceased donor kidney transplant recipients: a national cohort analysis". 对“每日一次与每日两次他克莫司在已故供体肾移植受者中的比较研究：一项国家队列分析”的评论。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-24 DOI: 10.1016/j.ajt.2026.09.028

Stefan Reuter, Dirk R J Kuypers, Klemens Budde

引用次数: 0

Reading Complement During Normothermic Kidney Perfusion. 正常肾灌注时补体读数。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-24 DOI: 10.1016/j.ajt.2026.09.030

Matthew L Holzner, Paolo Cravedi

引用次数: 0

World-First Allo- and Auto-Transplantation of Kidney Grafts Following Multiday Subzero Cryoprotectant-Free Preservation 世界首例无低温保护剂保存多日后肾移植的同种异体和自体移植

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2026-09-23 DOI: 10.1016/j.ajt.2026.09.001

R. Sellers, N. Lamsehchi, R. Truong, A. Almesallmy, A. Consiglio, A. Miller, B. Weegman, M. Taylor, B. Rubinsky, H. Yang, T. Pruett, J. Bova, E. Rahbar, S. Giwa, B. Oh, G. Brandacher, J. Weiner, M. Powell-Palm

引用次数: 0

Matrix metalloproteinase-9 associates with posttransplant liver injury despite attenuation by normothermic machine perfusion. 基质金属蛋白酶9与移植后肝损伤有关，尽管在常温机器灌注下减弱。

IF 8.1 2区医学

American Journal of Transplantation Pub Date : 2026-09-19 DOI: 10.1016/j.ajt.2026.09.026

Abraham M P den Dekker, Jason B Doppenberg, Maxime J van Kekem, Sadr Ul Shaheed, David Nasralla, Peter Friend, Bart van Hoek, Rutger J Ploeg, Ian P J Alwayn, Maria Letizia Lo Faro, Maarten E Tushuizen

{"title":"Matrix metalloproteinase-9 associates with posttransplant liver injury despite attenuation by normothermic machine perfusion.","authors":"Abraham M P den Dekker, Jason B Doppenberg, Maxime J van Kekem, Sadr Ul Shaheed, David Nasralla, Peter Friend, Bart van Hoek, Rutger J Ploeg, Ian P J Alwayn, Maria Letizia Lo Faro, Maarten E Tushuizen","doi":"10.1016/j.ajt.2026.09.026","DOIUrl":"10.1016/j.ajt.2026.09.026","url":null,"abstract":"Matrix metalloproteinase-9 (MMP-9) facilitates leukocyte infiltration during hepatic ischemia-reperfusion injury, and its inhibition mitigates injury in experimental models, underscoring its therapeutic potential in liver transplantation. Normothermic machine perfusion offers a unique opportunity to modulate inflammatory pathways during organ preservation and represents a potential window for MMP-9-targeted intervention. Compared with 10 livers preserved by static cold storage, 30 normothermic machine perfusion-preserved livers showed a markedly attenuated rise in plasma MMP-9 after reperfusion. In both preservation strategies, elevated MMP-9 was consistently associated with biochemical and clinical indicators of ischemia-reperfusion injury, including hepatocellular injury, postoperative liver and kidney dysfunction. Pro-MMP-9 was detected exclusively in recipients who developed early allograft dysfunction, graft failure, and/or death, suggesting a role in driving severe injury. In an independent cohort, perfusate and biliary MMP-9 in 10 normothermic machine perfusions reflected posttransplant cholestasis and subsequent biliary complications. Together, these findings identify MMP-9 as a relevant biomarker and a potential therapeutic target during machine perfusion.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0