American Journal of Transplantation最新文献_第5页

Outcomes and motivations in Unspecified (non-directed altruistic) Kidney Donation: Results from a UK prospective cohort study.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-28 DOI: 10.1016/j.ajt.2025.03.021

Hannah Maple, Petrut Gogalniceanu, Mira Zuchowski, Heather Draper, Lisa Burnapp, Paul McCrone, Joseph Chilcot, Sam Norton, Nizam Mamode

{"title":"Outcomes and motivations in Unspecified (non-directed altruistic) Kidney Donation: Results from a UK prospective cohort study.","authors":"Hannah Maple, Petrut Gogalniceanu, Mira Zuchowski, Heather Draper, Lisa Burnapp, Paul McCrone, Joseph Chilcot, Sam Norton, Nizam Mamode","doi":"10.1016/j.ajt.2025.03.021","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.03.021","url":null,"abstract":"Unspecified kidney donors (UKDs) increase the number of high-quality kidneys available for transplantation. This study aimed to determine whether the practice was acceptable, based on non-inferiority of donor physical and psychosocial outcomes when compared to specified kidney donors (SKDs). A longitudinal, prospective cohort study investigated potential living kidney donors from across all 23 UK adult kidney transplant centres. Participants completed validated questionnaires at four time points (recruitment, 2-4 weeks pre-donation, 3- and 12-months post-donation). Clinical outcome data were collected from NHS Blood and Transplant. 373 (of 837 recruited; 45.7%) went on to donate (November 2016 - January 2021). There were no differences in donation rates (204 SKDs (54.7%) vs 169 UKDs (45.3%); p=0.944). Both groups reported being motivated by the desire to help someone (p=0.157). Tests for non-inferiority indicated that UKDs do no worse than SKDs on psychosocial or clinical outcomes over 12-months, and costs are similar (p>0.05). This is the world's largest prospective observational study comparing SKDs and UKDs. It has demonstrated no differences in primary motivation, donation rates, regret, cost, or psychosocial and physical outcomes. These data should reassure transplant professionals and potential donors and can bolster confidence in the practice around the world.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The endothelial whisperer: rapamycin's second act in immune regulation-beyond T cells to endothelium.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-27 DOI: 10.1016/j.ajt.2025.03.023

Shuang Li, Dawei Zou

引用次数: 0

The impact of sodium-glucose cotransporter-2 inhibitors on dialysis risk and mortality in kidney transplant patients with diabetes.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-21 DOI: 10.1016/j.ajt.2025.03.019

Fu-Shun Yen, Chih-Cheng Hsu, Yun-Kai Yeh, Wan-Yin Cheng, Pei-Lun Liao, Chii-Min Hwu, James Cheng-Chung Wei

{"title":"The impact of sodium-glucose cotransporter-2 inhibitors on dialysis risk and mortality in kidney transplant patients with diabetes.","authors":"Fu-Shun Yen, Chih-Cheng Hsu, Yun-Kai Yeh, Wan-Yin Cheng, Pei-Lun Liao, Chii-Min Hwu, James Cheng-Chung Wei","doi":"10.1016/j.ajt.2025.03.019","DOIUrl":"10.1016/j.ajt.2025.03.019","url":null,"abstract":"Kidney transplantation is the optimal treatment for end-stage kidney disease, but many patients also have diabetes mellitus. This study compares long-term outcomes between new users of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and dipeptidyl peptidase-4 inhibitors (DPP-4i) in kidney transplant recipients with diabetes mellitus. Data from the TriNetX Collaborative Network, including 89,710 patients with diabetes mellitus who underwent kidney transplantation between January 1, 2015, and June 30, 2023, were analyzed. From this cohort, 1410 matched pairs of SGLT2i and DPP-4i users were selected based on propensity scores. The results showed that SGLT2i users had a lower risk of dialysis (hazards ratio: 0.694) and all-cause mortality (hazards ratio: 0.687) compared with DPP-4i users. There were no significant differences in the risk of posttransplant infections, transplant rejection, or hospitalization between the 2 groups. Additionally, SGLT2i users had significantly lower cumulative incidences of dialysis and mortality. In conclusion, this study, using data from TriNetX, demonstrated that SGLT2i treatment in kidney transplant recipients with diabetes mellitus is associated with lower risks of dialysis and mortality, suggesting it may help preserve kidney function and improve survival in this population.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The questions not addressed: Who should be performing the virtual crossmatch, how should it be classified, and how to obtain reimbursement?

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-21 DOI: 10.1016/j.ajt.2025.03.020

H Cliff Sullivan, Andrés Jaramillo, Sujata Gaitonde, Cathi Murphey, Soumya Pandey, Chang Liu, Peter Jindra, Luis G Hidalgo, Eric T Weimer, Caroline R Alquist, Gerald P Morris, Robert A Bray

引用次数: 0

10°C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia reperfusion injury.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-20 DOI: 10.1016/j.ajt.2025.03.018

Kaitlyn M Tracy, Yutaka Shishido, Mark Petrovic, Alexandria Murphy, TiOluwanimi Adesanya, Avery K Fortier, Timothy R Harris, Michael Cortelli, William D Tucker, Sean A François, Brandon Petree, Kimya Raietparvar, Victoria Simon, Carl A Johnson, Elizabeth Simonds, John Poland, Gabriella A Glomp, Christian Crannell, Jiancong Liang, Andrea Marshall, Antentor Hinton, Ciara M Shaver, Caitlin T Demarest, Rei Ukita, Ashish S Shah, Michael Rizzari, Martin Montenovo, M Ameen Rauf, Melanie McReynolds, Matthew Bacchetta

{"title":"10°C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia reperfusion injury.","authors":"Kaitlyn M Tracy, Yutaka Shishido, Mark Petrovic, Alexandria Murphy, TiOluwanimi Adesanya, Avery K Fortier, Timothy R Harris, Michael Cortelli, William D Tucker, Sean A François, Brandon Petree, Kimya Raietparvar, Victoria Simon, Carl A Johnson, Elizabeth Simonds, John Poland, Gabriella A Glomp, Christian Crannell, Jiancong Liang, Andrea Marshall, Antentor Hinton, Ciara M Shaver, Caitlin T Demarest, Rei Ukita, Ashish S Shah, Michael Rizzari, Martin Montenovo, M Ameen Rauf, Melanie McReynolds, Matthew Bacchetta","doi":"10.1016/j.ajt.2025.03.018","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.03.018","url":null,"abstract":"Optimized static cold storage has the potential to improve preservation of organs most vulnerable to ischemia reperfusion injury. Data from lung transplantation suggest that storage at 10°C improves mitochondrial preservation and subsequent allograft function compared to conventional storage on ice. Using a porcine model of donation after circulatory death (DCD), we compared static storage of livers at 10°C to ice. Livers (N=5 per group) underwent ten hours of storage followed by four hours of normothermic machine perfusion (NMP) for real-time allograft assessment. Allografts were compared using established NMP viability criteria, tissue immunostaining, and tissue metabolomics. 10°C stored livers demonstrated lower portal venous vascular resistance and greater hepatic artery vasoresponsiveness. Lactate clearance during NMP was similar between groups. 10°C stored livers showed favorable biochemical parameters of biliary viability, including greater bile volume, pH, and bicarbonate. Metabolomics analysis revealed increased aerobic respiration, improved electron transport chain function, and less DNA damage after reperfusion of livers stored at 10°C. Static storage of DCD livers with extended cold ischemic time at 10°C demonstrates superior allograft function with evidence of improved biliary viability and mitochondrial function compared to ice. These data suggest that storage at 10°C should be considered for translation to clinical practice.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Out-of-sequence, out of alignment, and out of time: Why the Organ Procurement Organization measures are at the root of this problem.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-19 DOI: 10.1016/j.ajt.2025.03.017

Alexandra K Glazier

引用次数: 0

Corrigendum to 'Establishing targets for goal-directed anesthesia in renal transplantation: A cohort analysis of high-saliency surgical time courses' [American Journal of Transplantation. Volume 24, Issue 11 (2024) Pages 2055-2065].

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-18 DOI: 10.1016/j.ajt.2025.03.013

Rohit Malyala, Anna-Lisa Tam-Vi Nguyen, Erika Escamilla, Alex Ng, Lucie Hammond, Sasha Vozynuk, Alireza Habibi, Amirreza Habibi, Hana Mehdic, Christopher Nguan

引用次数: 0

Decreasing efficiency in deceased donor kidney offer notifications under the new distance-based kidney allocation system.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-17 DOI: 10.1016/j.ajt.2025.03.010

Miko Yu, Syed Ali Husain, Joel T Adler, Lindsey M Maclay, Kristen L King, Prateek V Sahni, David C Cron, Jesse D Schold, Sumit Mohan

{"title":"Decreasing efficiency in deceased donor kidney offer notifications under the new distance-based kidney allocation system.","authors":"Miko Yu, Syed Ali Husain, Joel T Adler, Lindsey M Maclay, Kristen L King, Prateek V Sahni, David C Cron, Jesse D Schold, Sumit Mohan","doi":"10.1016/j.ajt.2025.03.010","DOIUrl":"10.1016/j.ajt.2025.03.010","url":null,"abstract":"Organ Procurement Organizations (OPOs) recover deceased donor kidneys and place them with matched recipients according to ranked match runs of patients, but offer notification practices differ across the OPOs and have changed following updates to allocation policy (kidney allocation system 250 [KAS250]). This national registry study used batch notification data to quantify time spent on kidney allocation and identify variations in batch notification practices across OPOs before and after the KAS250 allocation system era. Overall allocation time between the first and last offer notifications increased from a median of 1 to 7 hours under the KAS250 allocation system. For match runs of unplaced kidneys, allocation time increased from a median of 18 to 28 hours. Out-of-sequence (OOS) allocation, used by OPOs to limit nonutilization due to excess cold ischemia time, more than doubled in frequency between 2018 and 2022, with median time from first offer to initiation of OOS varying across OPOs from 0 to 47 hours. Increasing rates of organ nonutilization and the observed allocation practice differences based on organ quality demonstrate the urgent need for new approaches to achieve more efficient placement of hard-to-place kidneys. Data-driven approaches to optimize kidney allocation efforts will help ensure fairness in a system that currently allows for wide practice variation and frequent OOS allocation.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trained immunity: Can we get one transplanted kidney to last a lifetime?

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-17 DOI: 10.1016/j.ajt.2025.03.015

Lara C Pullen

引用次数: 0

Identifying target epitopes paves the way towards peptide-based therapies for tolerance induction.

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-03-17 DOI: 10.1016/j.ajt.2025.03.014

Faruk Sacirbegovic, Fadi G Lakkis

引用次数: 0