American Journal of Transplantation最新文献_第5页

Letter in reference to “The Rochester Protocol for living donor liver transplantation of unresectable colorectal liver metastasis: A 5-year report on selection, approval, and outcomes” 评论：不可切除的结直肠癌肝转移活体肝移植的罗切斯特方案：5年的选择、批准和结果报告

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2025-10-01 DOI: 10.1016/j.ajt.2025.06.008

Abdullah K. Malik , Madhukar S. Patel

引用次数: 0

Renal resistance trajectories during hypothermic machine perfusion in kidneys donated after circulatory death: Associations with donor characteristics and posttransplant outcomes—An analysis of COMPARE trial data 循环性死亡后捐赠肾脏在低温机器灌注期间的肾阻力轨迹：与供体特征和移植后结果的关联——一项比较试验数据分析

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2025-10-01 DOI: 10.1016/j.ajt.2025.06.014

Laurence Verstraeten , Steffen Fieuws , H. Sijbrand Hofker , Henri G.D. Leuvenink , Rutger J. Ploeg , Jacques Pirenne , Ina Jochmans , Consortium for Organ Preservation in Europe (COPE)

{"title":"Renal resistance trajectories during hypothermic machine perfusion in kidneys donated after circulatory death: Associations with donor characteristics and posttransplant outcomes—An analysis of COMPARE trial data","authors":"Laurence Verstraeten , Steffen Fieuws , H. Sijbrand Hofker , Henri G.D. Leuvenink , Rutger J. Ploeg , Jacques Pirenne , Ina Jochmans , Consortium for Organ Preservation in Europe (COPE)","doi":"10.1016/j.ajt.2025.06.014","DOIUrl":"10.1016/j.ajt.2025.06.014","url":null,"abstract":"<div><div><span>Renal resistance (RR) during hypothermic perfusion is commonly used as a factor to assess kidney quality, with most studies focusing on terminal RR measurements. We fitted a linear model to the entire RR trajectory using data from the randomized Consortium for Organ Preservation in Europe COMPARE trial and explored the relationship between the RR trajectory, donor characteristics, and posttransplant outcomes, also assessing the prognostic value of terminal RR for delayed graft function (DGF). Donor weight (F = 5.32; </span><em>P</em> = .005) and cause of death (F = 2.91; <em>P</em><span> = .008) were associated with the RR trajectory, whereas active oxygenation had no effect (F = 1.12; </span><em>P</em> = .33). The RR trajectory did not predict DGF (F = 1.93; <em>P</em><span> = .15), biopsy-proven acute rejection (F = 0.41; </span><em>P</em><span> = .66), 1-year kidney function (F = 0.61; </span><em>P</em><span> = .54), or 1-year graft survival (F = 0.47; </span><em>P</em> = .63). Terminal RR independently predicted DGF (odds ratio 1.14; 95% CI, 1.009-1.298; <em>P</em><span> = .03) but had limited prognostic value (area under the receiver operating characteristic curve, 0.63; 95% CI, 0.55-0.71), aligning with previous research. Our findings suggest that the RR trajectory reflects the kidney’s intrinsic response to perfusion, with donor weight and cause of death potentially influencing its progression. The absence of a relation between the RR trajectory and posttransplant outcomes stresses that using RR as a standalone criterion for kidney discard is not justified and may lead to unnecessary discard. Our findings also call for further validation in larger, more diverse cohorts.</span></div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 10","pages":"Pages 2161-2172"},"PeriodicalIF":8.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreas transplant outcomes in patients with human immunodeficiency virus infection 人类免疫缺陷病毒感染患者胰腺移植的结果

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2025-10-01 DOI: 10.1016/j.ajt.2025.06.001

Rashmi R. Bharadwaj , Gabriel Orozco , Xiaonan Mei , Hanine El-Haddad , Roberto Gedaly , Meera Gupta

{"title":"Pancreas transplant outcomes in patients with human immunodeficiency virus infection","authors":"Rashmi R. Bharadwaj , Gabriel Orozco , Xiaonan Mei , Hanine El-Haddad , Roberto Gedaly , Meera Gupta","doi":"10.1016/j.ajt.2025.06.001","DOIUrl":"10.1016/j.ajt.2025.06.001","url":null,"abstract":"<div><div>There is limited information on access and outcomes of patients living with human immunodeficiency virus (PLWH) who have undergone pancreas transplantation. We conducted a retrospective cohort study analyzing data from the United Network for Organ Sharing from July 1, 2001, to June 30, 2021. Recipients of pancreas transplant were stratified by HIV serostatus. Graft and patient survival were analyzed using Kaplan-Meier product limit estimates. Multivariable Cox proportional hazard models were generated to identify factors associated with increased mortality or graft loss. Fifty PLWH and 16 380 patients without HIV underwent pancreas (with kidney) transplantation. PLWH were more often male (<em>P</em> < .001), Black/African American (<em>P</em> = .009), and on Medicare (<em>P</em> = .004). There were no significant differences in waiting time (<em>P</em> = .159) or proportion of patients treated for rejection within 1 year of transplant (<em>P</em> = .189) between groups. There were no differences in pancreas graft survival (<em>P</em> = .964) and overall patient survival (<em>P</em> = .250) between the cohorts. Dialysis status was negatively associated with graft survival. Although PLWH were more likely to represent a historically marginalized population, their outcomes after pancreas transplant were similar to their counterparts without HIV.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 10","pages":"Pages 2267-2276"},"PeriodicalIF":8.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitization in Transplantation Assessment of Risk 2025 innate working group: The potential role of innate allorecognition in kidney allograft damage STAR 2025先天工作组：先天同种异体识别在肾移植损伤中的潜在作用。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2025-10-01 DOI: 10.1016/j.ajt.2025.06.030

Olivier Thaunat , Fadi G. Lakkis , Vasilis Kosmoliaptsis , Carrie Schinstock , Anat Tambur , Sebastiaan Heidt , Maarten Naesens

{"title":"Sensitization in Transplantation Assessment of Risk 2025 innate working group: The potential role of innate allorecognition in kidney allograft damage","authors":"Olivier Thaunat , Fadi G. Lakkis , Vasilis Kosmoliaptsis , Carrie Schinstock , Anat Tambur , Sebastiaan Heidt , Maarten Naesens","doi":"10.1016/j.ajt.2025.06.030","DOIUrl":"10.1016/j.ajt.2025.06.030","url":null,"abstract":"<div><div>In solid organ transplantation, the alloimmune response is traditionally attributed to the action of alloreactive T cells that recognize mismatched human leukocyte antigens, as well as antibody formation and antibody-mediated rejection. However, recent evidence indicates that these paradigms of involvement of the adaptive immune system in organ transplant rejection do not explain all cases of graft inflammation and that innate cell allorecognition plays a role. This review, conducted by the innate team of the Sensitization in Transplantation Assessment of Risk workgroup, summarizes the concepts and empirical evidence supporting innate allorecognition. The focus is on natural killer cell activation via missing self and monocyte activation through the signal regulatory protein α-CD47 pathway and <em>SIRPα</em> gene polymorphisms. A consensus definition of genetic missing self is proposed, necessitating both donor and recipient human leukocyte antigen class I genotyping and evaluation of the recipient inhibitory killer-cell immunoglobulin-like receptor genotype. Although in vitro studies and preclinical validations corroborate the potential of innate allorecognition concepts, further research is required to establish clinical utility. This article delineated future research directions to bridge the gap between theoretical promise and practical application in clinical transplantation.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 10","pages":"Pages 2038-2047"},"PeriodicalIF":8.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Fading Darling: Patient Voice as the Future of Transplant Trust. 褪色的宠儿：病人的声音作为移植信托的未来。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-09-26 DOI: 10.1016/j.ajt.2025.09.007

Earnest Davis

引用次数: 0

Reply to: Do T/B lymphocytes mask the protective effects of group 1 innate lymphoid cells against liver graft ischemia-reperfusion injury? T/B淋巴细胞是否掩盖了1组先天淋巴样细胞对肝移植缺血再灌注损伤的保护作用？

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2025-09-25 DOI: 10.1016/j.ajt.2025.09.014

Hidenobu Kojima, Thomas Morinelli, Yuan Zhai

引用次数: 0

A new principle to attenuate ischemia-reperfusion injury in kidney transplantation. 减轻肾移植缺血再灌注损伤的新原理。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-09-24 DOI: 10.1016/j.ajt.2025.08.024

Ali-Reza Biglarnia,Yuji Teramura,Sana Asif,Claudia Dührkop,Vivek Anand Manivel,Elin Manell,Patricia Hedenqvist,Anneli Rydén,Felix Sellberg,Karin Fromell,Sabine Hammer,Markus Huber-Lang,Kristina N Ekdahl,Marianne Jensen-Waern,Bo Nilsson

{"title":"A new principle to attenuate ischemia-reperfusion injury in kidney transplantation.","authors":"Ali-Reza Biglarnia,Yuji Teramura,Sana Asif,Claudia Dührkop,Vivek Anand Manivel,Elin Manell,Patricia Hedenqvist,Anneli Rydén,Felix Sellberg,Karin Fromell,Sabine Hammer,Markus Huber-Lang,Kristina N Ekdahl,Marianne Jensen-Waern,Bo Nilsson","doi":"10.1016/j.ajt.2025.08.024","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.08.024","url":null,"abstract":"Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugated lipids (PEG-LIPIDs), to be administered ex vivo intra-arterially to procured porcine kidney allografts before reperfusion. The aim was to create a protective cell membrane barrier, preventing the recognition of ligands exposed on renal cells by plasma proteins and cells of the intravascular innate immune system. In vitro cell studies confirmed the safety of PEG-LIPID with no observed toxicity and demonstrated its efficacy in masking ligands on various cell types. The PEG-LIPID was evaluated in 3 porcine allogeneic transplant models: 1 acute dual en bloc nonsurvival transplant model (duration 6 hours) and 2 survival models with low and high ischemic stress, respectively (duration 96 hours). No immunosuppression was employed. Across all 3 porcine transplant models, PEG-LIPID consistently mitigated ischemia-reperfusion-induced thromboinflammation (complement, coagulation, and kallikrein/kinin activation) and long-term inflammation with a marked reduction in cytokine responses, including lower levels of interleukin 6. The PEG-LIPID-treated kidneys exhibited significantly improved allograft function, reflected in robustly lower creatinine levels. This translational study confirmed that the PIG-LIPID is a strong candidate drug to mitigate ischemia-reperfusion injury in clinical kidney transplantation.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"41 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tacrolimus in Transplant Pregnancy: The Missing Details That Shape Risk. 他克莫司移植妊娠：塑造风险的缺失细节。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-09-23 DOI: 10.1016/j.ajt.2025.09.016

Shenglong Li,Longfei You

引用次数: 0

Letter in response to "The dynamics of deceased donor kidney transplant decision making: insights from studying individual clinicians' offer decisions." 回应“已故供者肾移植决策的动态：来自研究个体临床医生提供决定的见解”的信。

IF 8.8 2区医学

American Journal of Transplantation Pub Date : 2025-09-23 DOI: 10.1016/j.ajt.2025.09.018

Ingrid Woelfel,Carrie Jadlowiec,Amit Mathur

引用次数: 0

Arterial pressure and early acute kidney injury after liver transplantation - trials are needed but are difficult to perform. 肝移植后动脉压力和早期急性肾损伤-需要试验，但很难进行。