Acta Neurologica Scandinavica最新文献

{"title":"Nocturnal Hypoxemia and Daytime Sleepiness in Epilepsy With Obstructive Sleep Apnea-Hypopnea Syndrome: A Case–Control Polysomnography Study","authors":"Meina Wu,&nbsp;Sangru Wu,&nbsp;Sihang Wang,&nbsp;Fang Lin,&nbsp;Xiaolin Ji,&nbsp;Jinzhu Yan","doi":"10.1155/ane/6336114","DOIUrl":"https://doi.org/10.1155/ane/6336114","url":null,"abstract":"<p>Sleep disorders are common in patients with epilepsy, affecting their quality of life. In this study, we aimed to explore the sleep structure of adult patients with epilepsy and determine its correlation with different degrees of obstructive sleep apnea-hypopnea syndrome (OSAHS). We also examined the impact of intermittent hypoxemia on nocturnal sleep structure, respiratory-related events, and excessive daytime sleepiness (EDS). This case–control polysomnography study included 81 patients with epilepsy and 86 healthy controls. Polysomnography combined with video electroencephalography was used to assess sleep structure, respiratory-related events, and factors related to EDS. Patients with epilepsy had a higher prevalence of sleep disorders, hypoxemia, and EDS than controls. Comorbid moderate-to-severe OSAHS was associated with increased risk of severe hypoxemia and awakening. Intermittent and mean hypoxemia worsened with increasing apnea-hypopnea index. The incidence of EDS increased drastically in patients with comorbid moderate-to-severe OSAHS. The total sleep period time was a significant independent predictor of the occurrence of EDS in patients with comorbid moderate-to-severe OSAHS. The study findings indicate that patients with epilepsy experience changes in sleep structure, and the coexistence of OSAHS increases the risk of hypoxemia and EDS. These findings are useful in clinical prognostication of patients with epilepsy comorbid with OSAHS.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/6336114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into Modifiable Risk Factors of Vertigo Using the Mendelian Randomization Approach","authors":"Xingzhi Guo,&nbsp;Chen Hou,&nbsp;Peng Tang,&nbsp;Xin Zhang,&nbsp;Ning Gou,&nbsp;Li Chong,&nbsp;Peng Liu,&nbsp;Rui Li","doi":"10.1155/ane/8775816","DOIUrl":"https://doi.org/10.1155/ane/8775816","url":null,"abstract":"<p><b>Background:</b> Vertigo is a highly prevalent symptom with wide-ranging causes and adverse consequences. While common risk factors for vertigo have been identified, their causal relationship with vertigo remains not fully known. Thus, identifying the modifiable factors causally related to vertigo is crucial for preventing vertigo.</p><p><b>Methods:</b> A comprehensive Mendelian randomization study was employed to investigate the causal effects of vertigo among more than 40 genetically predicted modifiable risk factors, categorized into lifestyle traits, blood parameters, and metabolic comorbidities. This study used two different vertigo summary statistics from the deCODE and FinnGen consortia. Estimates were calculated using the inverse-variance weighted method and validated through alternative approaches.</p><p><b>Results:</b> The results indicated that genetically predicted higher educational level was significantly associated with a decreased risk of vertigo (deCODE: odds ratio (OR) = 0.757, 95% CI = 0.697–0.822, <i>p</i>_{FDR[false discover rate]} &lt; 0.001; FinnGen: OR = 0.796, 95<i>%</i>CI = 0.703–0.901, <i>p</i>_FDR = 0.007), while genetically predicted longer television watching was significantly associated with an increased risk of vertigo (deCODE: OR = 1.193, 95<i>%</i>CI = 1.076–1.323, <i>p</i>_FDR = 0.011; FinnGen: OR = 1.269, 95<i>%</i>CI = 1.085–1.483, <i>p</i>_FDR = 0.030). Additionally, genetically predicted elevated levels of alanine transaminase (ALT) were positively associated with the risk of vertigo. Genetically predicted increased physical activity was suggestively related to a reduced risk of vertigo, while higher triglyceride, body mass index (BMI), and diastolic blood pressure (DBP) were suggestively associated with an increased risk of vertigo (<i>p</i>_raw &lt; 0.05).</p><p><b>Conclusions:</b> Our findings indicate that genetically predicted increased educational levels and physical activity were associated with a decreased risk of vertigo, while higher levels of ALT and triglycerides, television watching time, BMI, and DBP were positively associated with the risk of vertigo. Thus, modifying these factors would decrease the risk of vertigo.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/8775816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Patterns of miRNA in the Experimental Autoimmune Encephalomyelitis (EAE)/MS Model Treated With Oenothera biennis Oil","authors":"Huri Demirci,&nbsp;Zozan Guleken,&nbsp;Sahabettin Selek,&nbsp;Nur Dogan,&nbsp;Busra Yuce,&nbsp;Emine Seyda Teloglu,&nbsp;Gulreyhan Sonuc,&nbsp;Cagla Yildiz,&nbsp;Esra Tiftik,&nbsp;Aysu Kilic,&nbsp;Beren Yildizbas,&nbsp;Zeynep Ece Bulut","doi":"10.1155/ane/3001118","DOIUrl":"https://doi.org/10.1155/ane/3001118","url":null,"abstract":"<p><b>Background:</b> Dysregulation of microRNA expression emerges as a crucial factor in the pathogenesis of autoimmune diseases, and their importance in modulating immune responses and disease progression is evident.</p><p><b>Methods:</b> This study investigated the expression patterns of miRNAs in the brain tissues of C57BL/6J mice using the experimental autoimmune encephalomyelitis (EAE) model, which mimics multiple sclerosis (MS). The model was treated with <i>Oenothera biennis</i> oil, a potential therapeutic agent.</p><p><b>Results:</b> Our research has revealed a novel and significant likelihood of association between miR-182-5p, miR-200c-3p, miR-206-3p, miR-429-3p, miR-1298-5p, and diseases resembling the EAE model, such as MS. This groundbreaking discovery could have profound implications in diagnosing and treating autoimmune diseases that mimic the EAE animal model.</p><p><b>Conclusions:</b> These miRNAs, identified in our study, might serve as potential therapeutic targets in MS, potentially leading to more effective treatments and improved patient outcomes.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/3001118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatosensory Evoked Potential N20 as a Prognostic Tool for Upper Limb Function in Stroke Patients: A Focus on Basal Ganglia and Thalamus","authors":"Shuai Yang,&nbsp;Chin-hsuan Chia,&nbsp;Pei-pei Xu,&nbsp;Ya Zong,&nbsp;Weiming Zhang,&nbsp;Xiao-pei Sun,&nbsp;Jing-yun Xu,&nbsp;Qing Xie","doi":"10.1155/ane/2060433","DOIUrl":"https://doi.org/10.1155/ane/2060433","url":null,"abstract":"<p><b>Objective:</b> This study is aimed at elucidating the prognostic utility of somatosensory evoked potentials (SEPs) N20 in the recovery of upper limb functionality among stroke patients with varying cerebral lesions.</p><p><b>Methods:</b> A cohort of 60 stroke patients enrolled in this study and stratified into two groups: 30 patients with strokes affecting the basal ganglia and 30 with thalamic involvement. Each patient underwent an SEP test after admission and participated in rehabilitation training for 3 months. Assessments were carried out using the Fugl–Meyer Assessment for Upper Extremity (FMA-UE), the Modified Ashworth Scale (MAS), and the Modified Barthel Index (MBI) at admission and 3 months after treatment to analyze the correlation between SEP-N20 indices and the function assessment scales in the two groups.</p><p><b>Results:</b> (1) SEP in stroke patients revealed notable abnormalities, in which a more pronounced reduction of the amplitude ratio of the N20 (SEPAR-N20) wave between the affected and unaffected sides was observed in the thalamus group (<i>p</i> &lt; 0.05). (2) After 3 months, a significant positive correlation was established between the improvement rate of FMA-UE scores and SEPAR-N20 in the basal ganglia group (<i>r</i> = 0.696, <i>p</i> &lt; 0.0001). Conversely, this correlation was not evident within the thalamus group (<i>r</i> = −0.157, <i>p</i> &gt; 0.05). (3) There was no significant correlation between MAS or MBI scores and SEPAR-N20 in either group (<i>p</i> &gt; 0.05).</p><p><b>Conclusion:</b> The extent of SEP abnormality poststroke is associated with the location of the lesion. Strokes involving the thalamus exhibited more pronounced changes in the N20 component. SEPAR-N20 might serve as a valuable predictor for the recovery of upper limb functionality, particularly in cases of basal ganglia strokes.</p><p><b>Trial Registration:</b> Chinese Clinical Trial Registry: ChiCTR2300075570</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2060433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disconnective Approach Leads to Superior Seizure Outcome Compared to Other Hemispheric Procedures—A Meta-Analysis","authors":"Barbara Puhahn-Schmeiser,&nbsp;Yvonne Höller,&nbsp;Franziska vom Hofe,&nbsp;Josef Zentner,&nbsp;Julia Jacobs,&nbsp;Kerstin Alexandra Klotz","doi":"10.1155/ane/3453458","DOIUrl":"https://doi.org/10.1155/ane/3453458","url":null,"abstract":"<p>Hemispherectomy is the most promising treatment for patients with severe hemispheric intractable epilepsy. Several techniques for this surgical intervention have been established, but the choice of technique is currently mostly dependent on the surgeon’s experience with a specific approach. We aim to demonstrate whether the choice of the surgical technique moderates surgical outcome in patients with severe hemispheric intractable epilepsy, as measured by seizure freedom and the incidence of death after surgery. We extracted 2382 articles from PubMed and Cochrane. Two independent experts selected 555 articles. We performed a meta-analysis for all studies and a pooled data analysis for studies where information on individual patients was available. None of the retrieved studies was randomized. Disconnective surgery yielded significantly higher rates of seizure freedom (0.83) than resective (0.70, <i>p</i> &lt; 0.001) or combined surgery (0.64, <i>p</i> &lt; 0.001) for patients with at least 1 year follow–up (<i>N</i> cases = 1165). For death (<i>N</i> cases = 1197), resective surgery had the highest rate of death within a year (0.07), significantly higher than disconnective surgery (0.012, <i>p</i> = 0.001) and combined surgical techniques (0.006, <i>p</i> &lt; 0.001). The assessed techniques did not systematically differ in rate of acute complications, but in their type, for example, acute neurological complications were most common after disconnective surgery (<i>p</i> &lt; 0.001), unspecific symptoms after resective surgery (<i>p</i> &lt; 0.004). Chronic neurological complications were most common after resective surgery (<i>p</i> &lt; 0.001). Seizure freedom is more likely following disconnective surgery as compared to resective or combined techniques. Disconnective and combined surgical techniques lead to fewer chronic complications and death than resective approaches.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/3453458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehospital Identification of Patients With Stroke—mNIHSS Versus FAST","authors":"Anders Lind,&nbsp;Fredrik Palmgren,&nbsp;Kristoffer Wibring","doi":"10.1155/ane/5511498","DOIUrl":"https://doi.org/10.1155/ane/5511498","url":null,"abstract":"<p><b>Introduction:</b> Early identification of stroke is important. The Face Arm Speech Test (FAST) and the modified National Institutes of Health Stroke Scale (mNIHSS) are two tools for stroke identification.</p><p><b>Aim:</b> The aims of this study are to investigate (a) whether the use of the mNIHSS in an emergency medical service (EMS) setting improves stroke/transient ischaemic attack (TIA) identification compared with the FAST, (b) to what extent “code stroke” is activated, and (c) which neurologic deficits/symptoms affect stroke identification.</p><p><b>Methods:</b> The method used is a retrospective pre–post-implementation study. EMS stroke identification was examined before and after the introduction of the mNIHSS, replacing the FAST, for EMS stroke screening. The FAST was replaced with the mNIHSS on 1 December 2022. Patients ≥ 18 years of age, diagnosed with stroke/TIA from 1 January 2021 to 31 May 2023 and under the care of the EMS, not more than 72 h before hospital care, were included. Data was manually extracted from EMS medical records regarding whether the FAST or mNIHSS was performed and if stroke/TIA was identified by the EMS personnel. The association between the applied stroke screening tool and EMS identification of stroke/TIA was then studied.</p><p><b>Results:</b> A total of 1849 EMS missions with a hospital-confirmed diagnosis of stroke/TIA were included. The most common diagnosis was ischaemic stroke, 59.4%. Haemorrhagic stroke constituted 10.8%, and TIA 29.8%. Stroke/TIA was identified in 82.5% of cases. When the mNIHSS was used for stroke assessment, stroke/TIA was identified in 87.6% of cases. The corresponding figure for the FAST was 88.4%. For patients in whom neurological symptoms were unassessed, or a method for assessment other than the mNIHSS/FAST was applied, the identification rate for stroke/TIA was 41.6%. When a physician was consulted, “code stroke” was activated in 58.6% of all cases. The corresponding figure for the mNIHSS was 57.2% and for the FAST 59.9%.</p><p><b>Conclusions:</b> The stroke identification rate does not appear to differ between the FAST and mNIHSS. The FAST and mNIHSS result in “code stroke” activation to an equal extent. Speech impairment and arm or leg paresis appear to improve EMS stroke identification. Conversely, impaired balance, convulsions, and vertigo/dizziness are associated with a lower identification rate. Both initial EMS suspicion of stroke and the subsequent application of a stroke scale appear to facilitate stroke identification.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/5511498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life, Anxiety and Depressive Symptoms in North Sea–Progressive Myoclonus Epilepsy: A Comparative Analysis With Other Hyperkinetic Movement Disorders","authors":"S. S. Polet,&nbsp;T. Bent,&nbsp;M. A. J. Tijssen,&nbsp;T. J. de Koning,&nbsp;E. R. Timmers","doi":"10.1155/ane/3302536","DOIUrl":"https://doi.org/10.1155/ane/3302536","url":null,"abstract":"<p><b>Objectives:</b> North Sea–Progressive Myoclonus Epilepsy (NS-PME) is a rare, childhood-onset disorder primarily characterized by movement disorders including progressive myoclonus and ataxia; subsequently accompanied by varying degrees of epilepsy. While motor symptoms are clearly defined, quality of life (QoL) has never been investigated in NS-PME. Additionally, nonmotor symptoms (NMS) including anxiety, depression, and cognitive problems are known to impact QoL and are increasingly being reported in other movement disorders. Hence, we examined the presence of anxiety and depression symptoms and the degree of QoL in NS-PME.</p><p><b>Materials and Methods:</b> Data were collected from multiple cross-sectional, survey-based studies conducted between 2014 and 2020 at the University Medical Center Groningen (UMCG), the Netherlands. First, data on QoL, anxiety, and depression symptoms were collected from 11 persons with NS-PME. Second, to compare outcomes in NS-PME with controls (<i>n</i> = 21) and other hyperkinetic movement disorders (HMDs; <i>n</i> = 146), data from previously conducted studies in the UMCG were reused. The surveys used include the SF-36/RAND-36, the Beck Anxiety Inventory (BAI), and the Beck Depression Inventory (BDI).</p><p><b>Results:</b> Symptoms of anxiety and depression were not present in the majority of persons with NS-PME. Compared to QoL scores of controls and other HMDs, persons with NS-PME scored significantly worse on physical functioning domains and, although nonsignificant, rendered the highest scores on emotional functioning domains.</p><p><b>Conclusion:</b> Firstly, we did not find indications for significantly increased anxiety or depression symptoms in NS-PME. Secondly, our findings on QoL in NS-PME reveal the following: (1) a floor effect of the SF-36 questionnaire and (2) suggest a disability paradox in NS-PME, in which persons with NS-PME reported good emotional well-being, despite physical challenges. To explore the presence of a disability paradox further and generate more suitable QoL measures for movement disorders such as NS-PME, future studies should elaborate on personal perspectives, including the exploration of coping mechanisms.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/3302536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Fatigue After Aneurysmal Subarachnoid Hemorrhage: A Prospective 5-Year Follow-Up Study","authors":"Sandra Bjerkne Wenneberg,&nbsp;Linda Block,&nbsp;Jonatan Oras,&nbsp;Pia Löwhagen Hendén,&nbsp;Jaquette Liljencrantz,&nbsp;Jane Hayden,&nbsp;Helena Odenstedt Hergès","doi":"10.1155/ane/2652197","DOIUrl":"https://doi.org/10.1155/ane/2652197","url":null,"abstract":"<p><b>Objectives:</b> Mental fatigue is a common and debilitating symptom following an aneurysmal subarachnoid hemorrhage (aSAH). However, its long-term prevalence and consequences remain unclear. In this longitudinal pilot study, the Mental Fatigue Scale (MFS) was used to evaluate the prevalence, severity, and dynamics of mental fatigue for up to 5 years and to correlate patient demographics and early complications to the development of mental fatigue.</p><p><b>Method</b>: Functional outcomes were scored using the Glasgow Outcome Scale-Extended (GOSE) during telephone interviews 1, 3, and 5 years after aSAH. The MFS questionnaires (maximum score 42, ≥ 10.5 points indicating mental fatigue) were subsequently sent by mail. Patient admission data and events during the acute phase were recorded.</p><p><b>Results:</b> Of 64 included patients, 31 could be assessed at all time points. Mental fatigue (MFS score ≥ 10.5) was present in 58%, 48%, and 52% of the patients at 1, 3, and 5 years, respectively. A significant decrease in the total MFS score was observed between 1 and 5 years (<i>p</i> = 0.025). The proportion of patients experiencing severe mental fatigue halved from 1 to 3 years. The median (range) MFS scores were significantly higher for women (14.5, 0–29.5) than for men (3, 0–17.5) at 1 year (<i>p</i> = 0.043). Compared with patients experiencing loss of consciousness at ictus (LOCi), those without LOCi exhibited a progressive decline in the total MFS score (<i>p</i> = 0.003).</p><p><b>Conclusions:</b> Although total MFS scores significantly improved, mental fatigue was a common and persistent symptom affecting half of the patients up to 5 years following aSAH. Mental fatigue was more prevalent in women than men; further, patients who experienced LOCi during the acute phase improved less over time. Our results highlight the importance of evaluating mental fatigue when assessing patient recovery and long-term outcomes.</p><p><b>Trial Registration:</b> Clinical Trial NCT06239142</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2652197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiologies of Rapidly Progressive Dementia: A Cross-Sectional Multicentric Tertiary Hospital Study","authors":"Eduardo de Novaes Costa Bergamaschi,&nbsp;Adaucto Wanderley da Nóbrega Junior,&nbsp;Edson Pillotto Duarte,&nbsp;Matheus Souza Steglich,&nbsp;Manuela Aparecida Kloeppel,&nbsp;Gabriel Martins Rodrigues,&nbsp;Iara de Sousa Coelho,&nbsp;Myllan Eiroa Feitosa,&nbsp;Katia Lin","doi":"10.1155/ane/2674746","DOIUrl":"https://doi.org/10.1155/ane/2674746","url":null,"abstract":"<p><b>Background:</b> Rapidly progressive dementia (RPD) is linked to several disorders. Reference centers for Creutzfeldt–Jakob disease have reported prion diseases as the most frequent cause of RPD. Alternatively, tertiary centers found high frequencies of nonprion diseases causing RPD, including a significant number of potentially treatable disorders. This study is aimed at describing the etiologies of RPD among inpatients from four tertiary centers in Florianópolis, Brazil.</p><p><b>Methods:</b> We reviewed medical records of patients hospitalized from 2001 to 2020 under codes of the 10th revision of the International Classification of Diseases potentially related to RPD. Patients who fulfilled the criteria for RPD were selected. RPD was defined when (1) the criteria of the National Institute on Aging–Alzheimer’s Association for dementia were met and (2) the disease duration was 730 days or less. We revised all etiological diagnoses according to established clinical criteria.</p><p><b>Results:</b> One hundred four patients with RPD were identified. The most frequent diagnostic groups were dementias of vascular origin (<i>N</i> = 27, 26.0%), nonprion degenerative diseases (<i>N</i> = 24, 23.0%), and mixed dementias (<i>N</i> = 9, 8.7%). All 11 patients with disease duration between 1 and 2 years had either dementia of vascular origin or nonprion degenerative dementia. Ten patients (9.6%)—diagnosed with autoimmune disorders, infectious disorders, neoplasia, or posterior reversible encephalopathy syndrome—showed improvement.</p><p><b>Conclusions:</b> Dementias of vascular origin were the most frequent cause of RPD in our sample, which differs from what has been previously reported by the literature. Patients with dementia duration between 1 and 2 years seem to have disorders usually associated with slow progression, while all potentially reversible cases had a duration of 1 year or less. Thorough investigation of RPD is paramount for the identification of potentially reversible etiologies.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2674746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Acrylamide Exposure and Cognitive Function in Older Adults: A Cross-Sectional Study","authors":"Yingying Chen,&nbsp;Qing Liu,&nbsp;Shi Tang,&nbsp;Zhenwei Gan,&nbsp;Xiaoyan Jia,&nbsp;Huimei Yu","doi":"10.1155/ane/6324207","DOIUrl":"https://doi.org/10.1155/ane/6324207","url":null,"abstract":"<p><b>Background:</b> Cognitive decline is an important factor affecting the health and well-being of older adults. Previous studies have shown that acrylamide (AA) caused neurological damage among occupationally exposed workers. However, the effect of AA on cognitive function in general older adults is unclear yet. Therefore, this cross-sectional study is aimed at examining the relationships between blood markers of AA and cognitive function in the general elderly population.</p><p><b>Methods:</b> Four hundred sixty-seven older adults (230 men and 237 women) aged 60 years and older from the National Health and Nutrition Examination Survey cycles (2013–2014) were included in this study. Logistic regression models were applied to explore the relationships between blood markers of AA and cognitive function.</p><p><b>Results:</b> After adjusting for all confounders, at the animal fluency test (AFT) dimension, the odds ratio (OR) for individuals in the highest tertile of hemoglobin (Hb) adducts of acrylamide (HbAA) and its metabolite glycidamide (hemoglobin adducts of glycidamide (HbGA)) were 0.251 (95% confidence interval (CI): 0.090, 0.699) and 0.354 (95% CI: 0.164, 0.761), respectively, compared with individuals in the lowest tertile, indicating that both HbAA and HbGA were negatively associated with the decline in cognitive function in dimension AFT. No significant associations were seen on other dimensions. Moreover, HbGA/HbAA had no association with any dimensions of cognitive decline.</p><p><b>Conclusion:</b> Collectively, our results suggest that HbAA and HbGA are not positively associated with cognitive decline in the general elderly population and are negatively related to the AFT dimension of cognitive impairment.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/6324207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}