Acta Neurologica Scandinavica最新文献

{"title":"N-Methyl-D-Aspartate Receptor (NMDAR) Antibodies Induce Diverse Calcium Activity Patterns on Cultured Astrocytes and Astrocyte–Neuron Cocultures","authors":"Neşe Ayşit,&nbsp;Sevginur Bostan,&nbsp;Canan Aysel Ulusoy,&nbsp;Erdem Tüzün,&nbsp;Fazlı Kemal Bayat","doi":"10.1155/ane/2861013","DOIUrl":"https://doi.org/10.1155/ane/2861013","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Preliminary evidence suggests that astrocytes might contribute to the disease mechanisms of N-methyl-D-aspartate receptor (NMDAR) encephalitis. However, the precise role of astrocytes in the pathogenesis of encephalitis is poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To characterize the impact of NMDAR antibodies on the activity of astrocytes, we isolated and purified serum IgG from three patients with NMDAR encephalitis and three healthy controls. Primary cultured mouse astrocytes and neuron–astrocyte cocultures were incubated with 5 <i>μ</i>g patient or control IgG for 12 and 24 h. Cell viability and astrocyte activity were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and calcium (Ca²⁺) imaging studies (using a vector expressing a genetically encoded indicator under the GFAP promoter), respectively. Supernatant levels of TNF-<i>α</i>, a mediator of astrocyte–neuron interactions, were measured by ELISA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Purified serum IgG from N-methyl-D-aspartate receptor-antibody positive patients (NMDAR-Ab+ IgG) and healthy controls did not alter the viability of isolated astrocytes and cocultures. NMDAR-Ab+ IgG suppressed the duration and amplitude of Ca²⁺ activity of isolated astrocytes at 12 and/or 24 h, whereas all parameters of Ca²⁺ activity were enhanced by NMDAR-Ab+ IgG in astrocyte–neuron cocultures at 12 h. TNF-<i>α</i> levels were increased in supernatants of NMDAR-Ab+ IgG–administered astrocyte–neuron cocultures but not isolated astrocytes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>This study provides the first preliminary evidence on the impact of patient-derived NMDAR-Ab+ IgG on astrocytic activity. Our results imply that the interaction of NMDAR-Abs with neurons and astrocytes creates a positive feedback loop reinforcing the activation of astrocytes. TNF-<i>α</i> might be one of the perpetrators of this loop.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2861013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145366861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroneal Electrical Transcutaneous Neuromodulation (Peroneal eTNM) in the Treatment of Essential Tremor","authors":"Petra Bártová,&nbsp;Eva Augste,&nbsp;Filip Strouhal,&nbsp;Jan Krhut,&nbsp;Martin Slovák,&nbsp;Lukáš Peter,&nbsp;Martin Schmidt,&nbsp;David Školoudík","doi":"10.1155/ane/5231029","DOIUrl":"https://doi.org/10.1155/ane/5231029","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Given the limitations of the currently available treatment options for essential tremor (ET), the development of a safe and effective method to manage ET is warranted. The aim of this study is to investigate the safety and feasibility of peroneal electrical transcutaneous neuromodulation (peroneal eTNM) in patients with ET.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients enrolled in the study were treated with peroneal eTNM daily for 30 min over 6 weeks, followed by a 6-week follow-up period without stimulation. Peroneal eTNM was administered alongside their chronic medication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 12 patients (eight men, mean age 60.2 ± 17.7 years, mean disease duration 9.2 ± 7.8 years) were enrolled. All patients were able to use the stimulation at home without assistance. During the study, only two transient treatment-related adverse events were reported. Seven patients (58.3%) reported subjective improvement using the Patient Global Impression of Improvement questionnaire at the end of treatment (EoT), and five patients (41.7%) reported improvement at the end of study (EoS). We observed a significant reduction in the total Essential Tremor Rating Assessment Scale (TETRAS) score, with median (IQR) values decreasing from 38.3 (30.5–49.0) at baseline to 36.5 (20.8–41.5) at EoT and 34.5 (13.0–36.8) at EoS. Similarly, tremor severity, as measured visually and with an accelerometer, showed significant improvement. However, no significant changes were observed in tools assessing quality of life and general disability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This pilot study demonstrates that peroneal eTNM is safe and feasible for patients with ET. Despite the limited sample size, ET patients treated with peroneal eTNM showed significant improvement in tremor severity as measured by both subjective and objective tools. Future studies with a larger sample size and sham-controlled design are needed to confirm these findings and further validate the potential of peroneal eTNM in the treatment of patients with ET.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NTC06036368</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/5231029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145366489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Alcohol Consumption and Persistent Posttraumatic Headache After Mild Traumatic Brain Injury: A Single-Center Study","authors":"Yuanrun Zhu,&nbsp;Gengjing Chen,&nbsp;Jin Huang,&nbsp;Ping He,&nbsp;Zhifeng Wu,&nbsp;Chen Jiang","doi":"10.1155/ane/8359474","DOIUrl":"https://doi.org/10.1155/ane/8359474","url":null,"abstract":"<p>Traumatic brain injury (TBI) is a prevalent neurosurgical emergency that imposes a significant healthcare burden. Even mild TBI can lead to chronic headache. However, the relationship between posttraumatic headache and alcohol use remains unclear. This study is aimed at investigating the association between alcohol consumption and the development of persistent posttraumatic headache following mild TBI. Adult patients with mild TBI, treated between January 2023 and December 2023, were included. Follow-up interviews were conducted at least 6 months after hospital discharge. Logistic regression analysis was employed to adjust for baseline characteristics and other comorbidities. A total of 207 patients were analyzed, with an overall incidence of persistent posttraumatic headache of 36.2%. The regression analysis revealed an inverse relationship between alcohol consumption and persistent posttraumatic headache (OR: 0.355, 95% CI: 0.175, 0.717) after adjusting for confounding factors. This association remained unchanged after accounting for TBI- or headache-related alcohol avoidance (OR: 0.436, 95% CI: 0.212, 0.897). Female sex emerged as an independent risk factor for persistent posttraumatic headache (OR: 2.206, 95% CI: 1.107, 4.393). Other variables, including age, duration of hospital stay, in-hospital neurological symptoms, vomiting, sleep disorders, education level, and comorbidities, did not significantly affect the risk of persistent posttraumatic headache in the regression model. In conclusion, alcohol consumption is inversely associated with persistent posttraumatic headache in mild TBI patients. Although TBI- or headache-induced alcohol avoidance provides a plausible explanation for this inverse relationship, it may not fully account for the phenomenon. Female patients are at a higher risk of developing persistent posttraumatic headache after mild TBI. Further studies with low bias are needed to explore this relationship. Medical recommendations regarding alcohol consumption should be provided cautiously, considering the latest evidence, to inform patients with mild TBI about the potential risk of posttraumatic headache.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/8359474","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher High-Density Lipoprotein Cholesterol Levels Are Associated With an Unfavorable Outcome After Thrombolysis for Stroke: The Lipid Paradox","authors":"Ming-Ya Luo,&nbsp;Fu-Liang Zhang,&nbsp;Shan Lv,&nbsp;Yu Song,&nbsp;Yao Yu,&nbsp;Zhen-Ni Guo,&nbsp;Yi Yang","doi":"10.1155/ane/1668467","DOIUrl":"https://doi.org/10.1155/ane/1668467","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Effects of serum cholesterol levels on stroke outcomes remain controversial, especially in intravenous thrombolysis (IVT)–treated patients. This study explored the association between lipid levels and outcomes in patients with acute ischemic stroke (AIS) who received IVT with recombinant tissue plasminogen activator (rt-PA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>AIS patients who received rt-PA thrombolysis from April 2015 to December 2018 were retrospectively enrolled. Fasting lipid profiles, including total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C), were collected. Stroke outcomes included hemorrhagic transformation, 3-month unfavorable outcome (modified Rankin scale &gt; 2), and 3-month mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We enrolled 698 IVT-treated patients with AIS. Binary logistic regression analysis showed that a higher HDL-C level was independently associated with a higher risk of a 3-month unfavorable outcome (odds ratio 1.999, 95% confidence interval 1.204–3.320, <i>p</i> = 0.007). Patients were then divided into high and low HDL-C groups according to a cutoff HDL-C of 1.415 mmol/L. After propensity score matching to adjust for baseline factors, patients in the high HDL-C group were more likely to experience a 3-month unfavorable outcome than those in the low HDL-C group (<i>p</i> = 0.041).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A higher HDL-C level was independently associated with a 3-month unfavorable outcome in IVT-treated patients with AIS. The current study received approval from the Ethics Committee of the First Hospital of Jilin University (No. NCT05028868).</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/1668467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Oropharyngeal Dysphagia and Malnutrition in Neurological Patients","authors":"Līga Savicka,&nbsp;Baiba Kubile,&nbsp;Guna Bērziņa","doi":"10.1155/ane/3715519","DOIUrl":"https://doi.org/10.1155/ane/3715519","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Oropharyngeal dysphagia (OD) and malnutrition are prevalent among neurological patients, particularly those with cerebrovascular disease and neurodegenerative conditions. Both conditions can significantly impact the health and recovery of these individuals. The study was aimed at identifying risk factors associated with OD and malnutrition, using the biopsychosocial model to explore the relationships between these outcomes and various risk factors, including body structures, body functions, level of activity and participation, and contextual factors.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This cross-sectional study included 144 neurological patients, aged 19–93 years. Data were collected on a range of factors, including oral and pharyngeal structures, appetite, cognitive function, and social participation. The prevalence of OD and malnutrition was assessed using the Standardized Swallowing Assessment and Global Leadership Initiative on Malnutrition (GLIM) criteria. Risk factors were evaluated using logistic regression models based on the biopsychosocial model.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The prevalence of OD and malnutrition in the study sample was 27.1% and 35.4%, respectively. Significant risk factors for OD included impaired oral structures (tongue, lips, and soft palate), cognitive dysfunction, and appetite loss. Malnutrition was associated with soft palate impairment, reduced calf circumference, weight loss, and social isolation. Higher scores in the WHO Disability Assessment Schedule (WHODAS 2.0) getting along domain (indicating poor social functioning) and living alone were linked to increased malnutrition risk. No significant relationship was found between environmental factors or health conditions and OD or malnutrition. While most dysphagia patients retained some ability to eat orally, dietary adaptations were frequently required.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study highlights the high prevalence of OD and malnutrition among neurological patients and identifies key risk factors, including both physical impairments and psychosocial elements. Early screening and targeted interventions, such as dietary modifications and cognitive support, are essential for improving patient outcomes. A biopsychosocial approach is effective in understanding the multifactorial nature of these conditions and informs clinical practice. Future longitudinal studies are necessary to better understand causal relationships and enhance the generalizability of these findings.&lt;/p&gt;\u0000 ","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/3715519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression of Family Caregivers of Patients With Disorders of Consciousness: A Systematic Review","authors":"Fangfang Shou,&nbsp;Junyang Wu,&nbsp;Jing Wang,&nbsp;Charlotte Grégoire,&nbsp;Wangshan Huang,&nbsp;Meiqi Li,&nbsp;Charlène Aubinet,&nbsp;Anqi Wang,&nbsp;Natu Hu,&nbsp;Steven Laureys,&nbsp;Haibo Di","doi":"10.1155/ane/6249080","DOIUrl":"https://doi.org/10.1155/ane/6249080","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The main purpose of this study was to systematically analyze the state of depression among family caregivers of patients with disorders of consciousness (DoC) and explore the influencing factors of depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Data Sources</h3>\u0000 \u0000 <p>A systematic review. English-language articles published from January 1, 1994, to July 1, 2024, were searched using Web of Science, PubMed, Embase, and MEDLINE databases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Selection</h3>\u0000 \u0000 <p>The study selected for review had to assess the level of depression, or the predictors of depression, among family caregivers of DoC patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 18 studies, encompassing 2155 participants, met the predetermined inclusion criteria. Depending on the study, 15.5%–82.6% of these caregivers of DoC patients reported depression. Eight studies showed that positive coping strategies (e.g., acceptance and problem-focused strategies) predicted lower levels of depression. Two longitudinal studies showed a significant decrease in depression over time. Two of the four studies that discussed gender showed a greater prevalence of depression in female caregivers than in males. In addition, low quality of life, poor social support, unmet emotional support needs, and financial problems increase the level of depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Family caregivers are suffering from depression. Duration of illness (i.e., DoC), gender of family caregivers, coping strategies, and social support influenced the proportion of depression symptoms. These results open the path to the study of interventions aiming to support the mental health of family caregivers of DoC patients and considering these influences. Improving the mental health of family caregivers could ultimately allow an increase in the quality of life of patients and promote their recovery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/6249080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Eslicarbazepine Acetate Response in Intellectual Disability Population Versus General Population”","authors":"","doi":"10.1155/ane/9860292","DOIUrl":"https://doi.org/10.1155/ane/9860292","url":null,"abstract":"<p>J. Allard, C. Lawthom, W. Henley, et al., “Eslicarbazepine Acetate Response in Intellectual Disability Population Versus General Population,” <i>Acta Neurologica Scandinavica</i> 143, no. 3 (2020): 219-336, https://doi.org/10.1111/ane.13368.</p><p>In the article titled “Eslicarbazepine Acetate Response in Intellectual Disability Population Versus General Population,” there were errors in the Abstract, Results, and Conclusions sections. These errors are shown below.</p><p><b>Summary Note:</b> The author has mistakenly described the data presented in Table 3 in the manuscript text—that is, the percentages for “ID” and “no ID” have been switched by accident. The areas to be corrected are as follows:</p><p>Currently reads</p><p>“Seizure improvement of ‘over 50%’ was lower in the ‘ID’ group (35% compared to 56%).”</p><p>Should read</p><p>“Seizure improvement of ‘over 50%’ was lower in the ‘no ID’ group (35% compared to 56%).”</p><p>Currently reads</p><p>“Seizure improvement of ‘over 50%’ was lower in the ‘ID’ group (35% compared to 56%).”</p><p>Should read</p><p>“Seizure improvement of ‘over 50%’ was lower in the ‘no ID’ group (35% compared to 56%).”</p><p>Currently reads</p><p>“The impact of ESL treatment on seizure rate (&gt; 50% seizure reduction) is higher for our ‘no ID’ group (56%) when compared with our ‘ID’ group (35%), but this difference is not significant.”</p><p>Should read</p><p>“The impact of ESL treatment on seizure rate (&gt; 50% seizure reduction) is higher for our ‘ID’ group (56%) when compared with our ‘no ID’ group (35%), but this difference is not significant.”</p><p>We apologize for these errors.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/9860292","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Life Participation in Young Stroke Survivors: Independent Associations With Depressive Symptoms, Communication Skills, Mobility, and Social Situation","authors":"Hans Samuelsson,&nbsp;Petra Redfors,&nbsp;Lukas Holmegaard,&nbsp;Sofia Hjalmarson,&nbsp;Johanna Zeijlemaker,&nbsp;Christian Blomstrand,&nbsp;Christina Jern,&nbsp;Katarina Jood","doi":"10.1155/ane/8814382","DOIUrl":"https://doi.org/10.1155/ane/8814382","url":null,"abstract":"<p><b>Background:</b> Resuming active participation in valued areas of life is critical for stroke survivors; however, little is known about the possible components restricting life participation in young survivors. Here, we identified independent determinants of such long-term restrictions among potential stroke-related complications and explored the interplay between these potential explanatory variables.</p><p><b>Methods:</b> Seven years after the index stroke, a consecutive cohort of young (18–54 years at onset) ischemic stroke survivors (<i>n</i> = 222) reported their self-rated participation according to the Stroke Impact Scale (SIS). Using linear regression and partial correlations, the independent association with the SIS participation score was analyzed for the following potential correlates: depressive symptoms, anxiety, cognition, mobility, activities of daily living, fatigue, neurological deficits, demographics, and vascular risk factors.</p><p><b>Results:</b> Fifty-seven percent reported restrictions sometimes or more often for at least one of the seven SIS participation items, with the largest proportions reported for “controlling life” (40%), “work” (37%), and “active recreation” (37%). Communication (partial <i>r</i> = 0.39, <i>p</i> &lt; 0.001), depressive symptoms (partial <i>r</i> = −0.30, <i>p</i> &lt; 0.001), mobility (partial <i>r</i> = 0.20, <i>p</i> = 0.029), and social situation (living alone; partial <i>r</i> = −0.19, <i>p</i> = 0.02) were independently associated with participation. The structure of the interplay between the explanatory variables was further analyzed using a network model.</p><p><b>Conclusion:</b> Participation restrictions among young ischemic stroke survivors in the long term are common and have been previously reported. Limitations in communication and depressive symptoms were important determinants of restricted participation as well as limited mobility and living alone, emphasizing the need for sustained interventions and support from a broad perspective for young stroke survivors.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/8814382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Serum TGF-β1 Is Linked to Guillain–Barré Syndrome Severity in Bangladeshi Patients: No Association With TGF-β1 −509C/T and +869C/T Polymorphisms","authors":"Rasel Ahmed,&nbsp;Shoma Hayat,&nbsp;Asaduzzaman Asad,&nbsp;Israt Jahan,&nbsp;Moriam Akter Munni,&nbsp;Ruma Begum,&nbsp;Sarah Khurshid,&nbsp;Morium Akter Mukta,&nbsp;Zhahirul Islam","doi":"10.1155/ane/2063433","DOIUrl":"https://doi.org/10.1155/ane/2063433","url":null,"abstract":"<p>Guillain–Barré syndrome (GBS) is an autoimmune peripheral nerve disorder characterized by progressive muscle weakness. Transforming growth factor-beta 1 (TGF-<i>β</i>1) is a major immune-regulating cytokine; therefore, serum concentration of TGF-<i>β</i>1 and its genotypes may contribute to developing GBS. This study is aimed at evaluating the changes in TGF-<i>β</i>1 serum level in GBS and investigating the association of <i>TGF-β1</i> gene +869C/T and −509C/T) single-nucleotide polymorphisms (SNPs) with GBS susceptibility and TGF-<i>β</i>1 cytokine level. A case–control study was conducted with 200 GBS patients and 200 age-, sex-, and ethnicity-matched healthy controls (HCs). Serum levels of TGF-<i>β</i>1 and anti-GM1 autoantibodies were assessed using enzyme-linked immunosorbent assays. The tetra-primer amplification refractory mutation system-PCR was used to detect the targeted <i>TGF-β1</i> gene SNPs. In this study, 79% of patients were reported with antecedent events, primarily diarrhea (44%). Overall, 89% of patients were affected with severe GBS; among them, 17% required mechanical ventilation and 21% remained functionally disabled after 6 months. TGF-<i>β</i>1 serum levels were significantly higher in GBS patients compared to HCs (<i>p</i> &lt; 0.0001), demonstrating a cut-off of &gt; 414.02 ng/mL for GBS. In addition, serum levels were correlated to higher GBS-disability scores (<i>r</i>_s = 0.338, <i>p</i> &lt; 0.0001) and were associated with severe GBS (<i>p</i> = 0.04). Elevated TGF-<i>β</i>1 concentration was associated with poor clinical outcomes in patients at 6 months of disease onset (<i>p</i> = 0.006). The TGF-<i>β</i>1-509 T/T genotype was more frequent in <i>Campylobacter jejuni</i>-seropositive patients compared to seronegative patients (OR = 2.87, <i>p</i>_<i>c</i> = 0.04), especially in those with the axonal GBS variant (OR = 3.8, <i>p</i>_<i>c</i> = 0.07). However, no significant associations were found between <i>TGF-β1</i> SNPs and overall the disease susceptibility or serum TGF-<i>β</i>1 concentration. The study concluded that elevated serum TGF-<i>β</i>1 concentration is associated with both GBS susceptibility and clinical severity and is linked to worse functional outcomes. While the –509 T/T genotype may be linked to <i>C. jejuni</i>–driven axonal GBS, there was no overall polymorphism association with GBS risk or cytokine levels. These findings might be crucial in understanding and predicting disease susceptibility and severity of GBS.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2063433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors, Efficiency, and Outcomes of Radiofrequency Ablative Therapy for Sacroiliac Joint Syndrome: A Retrospective Study","authors":"Safwan Saffour,&nbsp;Karim Gaber,&nbsp;Christoph Sippl,&nbsp;Bernardo Reyes,&nbsp;Stefan Linsler,&nbsp;Joachim Oertel","doi":"10.1155/ane/4244669","DOIUrl":"https://doi.org/10.1155/ane/4244669","url":null,"abstract":"<p><b>Introduction:</b> The sacroiliac joint (SIJ), despite limited mobility, plays a crucial role in load transfer and pelvic stability. As a true diarthrodial joint, it accounts for 15%–38% of low back pain cases. This study evaluated the clinical outcomes of radiofrequency ablation (RFA) for SIJ syndrome and examined predictors of treatment response.</p><p><b>Methods:</b> We retrospectively analyzed 101 patients treated with intra-articular RFA between 2017 and 2020. Pain and function were assessed using the Visual Analog Scale (VAS), Oswestry disability index (ODI), and McNab criteria.</p><p><b>Results:</b> The cohort (53.5% female, mean age 69.0 ± 14.2 years, BMI 28.18 ± 4.87) showed significant improvements in pain (VAS: 7.68 ± 1.4 to 2.6 ± 1.54 at 24 h, <i>p</i> &lt; 0.001) and function (ODI: 57.5 ± 17.5 to 37.9 ± 16.97 at 12 months, <i>p</i> &lt; 0.001). McNab scores improved from 2.36 ± 1.03 at 6 weeks to 3.32 ± 0.88 at 12 months (<i>p</i> &lt; 0.001). Higher BMI was strongly associated with poorer outcomes (VAS <i>r</i> = 0.433–0.719, ODI <i>r</i> = 0.990, McNab <i>r</i> = –0.960 to –0.914; all <i>p</i> &lt; 0.001). Prior spinal surgery affected short-term recovery but not long-term results.</p><p><b>Conclusion:</b> Intra-articular RFA is an effective treatment for SIJ syndrome, offering sustained pain relief and functional improvement up to 12 months. High BMI negatively impacts outcomes, highlighting the value of adjunctive strategies like weight management and rehabilitation to enhance long-term success.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/4244669","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}