Acta Neurologica Scandinavica最新文献

{"title":"Joint Association of High-Density and Nonhigh-Density Lipoprotein Cholesterol With Risk of Intracranial Hemorrhage: A Cohort Study","authors":"Shuting Liu,&nbsp;Wenjun Zhu,&nbsp;Linhao Liu,&nbsp;Jingbo Yang,&nbsp;Hangkuan Liu,&nbsp;Linjie Li,&nbsp;Tianqi Yang,&nbsp;Xixi Tao,&nbsp;Xin Zhou,&nbsp;Qing Yang","doi":"10.1155/ane/8754603","DOIUrl":"https://doi.org/10.1155/ane/8754603","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The combined impact of different lipid fractions on intracranial hemorrhage (ICH) risk remains underexplored, particularly in high-risk populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study examined the joint association of high-density lipoprotein cholesterol (HDL-C) and nonhigh-density lipoprotein cholesterol (non-HDL-C) with ICH risk and identify high-risk combinations in patients receiving direct oral anticoagulants (DOACs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study of 21,392 patients newly initiating DOAC therapy, using data from the Tianjin Health and Medical Data Platform. Multivariable Cox regression and restricted cubic spline analyses were employed. The joint association of HDL-C and non-HDL-C was visualized using heat maps.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 21,392 included patients (median age 68.0 years; 51% male), restricted cubic spline analyses revealed a linear inverse association for HDL-C and a nonlinear association for non-HDL-C with ICH risk. Joint analysis demonstrated that the risk of ICH increased progressively with decreasing levels of both lipids, particularly when both were low concurrently.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Concurrent low levels of HDL-C and non-HDL-C were associated with higher ICH risk, suggesting that comprehensive lipid assessment may aid in risk stratification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/8754603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Lambda Free Light Chains in Early Multiple Sclerosis","authors":"Kamila Zondra Revendova,&nbsp;David Zeman,&nbsp;Krystof Damian Svub,&nbsp;Pavla Hanzlikova,&nbsp;Aravind Ganesh,&nbsp;Pavlina Kusnierova","doi":"10.1155/ane/8187265","DOIUrl":"https://doi.org/10.1155/ane/8187265","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lambda free light chains (LFLC) measures in cerebrospinal fluid (CSF) may reflect early CNS inflammation, but their prognostic value in early relapsing–remitting multiple sclerosis (RRMS) remains unclear. This study evaluated whether baseline LFLC-related parameters are associated with risk of second relapse, MRI activity and progression to Expanded Disability Status Scale (EDSS) ≥ 4.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-centre retrospective study enrolled patients aged ≥ 18 years with RRMS who had experienced no more than one clinical relapse at lumbar puncture and had baseline paired CSF/serum FLC measurements. Baseline LFLC parameters, including CSF LFLC concentration, LFLC index, CSF LFLC/IgG ratio, CSF KFLC/LFLC ratio and oligoclonal LFLC bands, were analysed in relation to clinical and radiological outcomes using Cox proportional hazards models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analyses included 91 RRMS patients: 65.9% female; median age at disease onset, 34.7 years (IQR 15.4) and median follow-up period, 36 months (IQR 25). Baseline LFLC-related measures were not associated with the risk of second relapse, MRI activity or progression to EDSS ≥ 4 in multivariable analyses. The number of CSF-restricted oligoclonal LFLC bands was associated with reaching EDSS ≥ 4 in univariable analysis (HR 1.09, 95% CI 1.01–1.17); however, this association was not confirmed after adjustment for baseline EDSS and treatment exposure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>LFLC-related measures were not independently associated with relapse risk, MRI activity or disability progression to EDSS ≥ 4 in early RRMS. These findings suggest limited prognostic value of LFLC biomarkers in early disease stages and support the need for further prospective multicentre studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/8187265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Language and Cognition After Stroke: Longitudinal Observational Study","authors":"Aleksi J. Sihvonen,&nbsp;Salla Hanhela,&nbsp;Vera Leo,&nbsp;Ilja Salakka,&nbsp;Anni Pitkäniemi,&nbsp;Teppo Särkämö","doi":"10.1155/ane/3164442","DOIUrl":"https://doi.org/10.1155/ane/3164442","url":null,"abstract":"<p>Poststroke language impairment, including aphasia, often co-occurs with cognitive and emotional symptoms, complicating recovery. Understanding these combined impairments and their neural bases is critical for effective rehabilitation. This study examined associations between aphasia severity, language-mediated cognitive deficits, and lesion patterns at acute and subacute stages. We analyzed data from 100 stroke patients, assessing language and cognitive performance at the acute stage (1-week poststroke) and 3 months poststroke. Acute stage lesion data were used to examine distributed lesion patterns and anatomical overlap between poststroke language impairment severity, based on Boston Diagnostic Aphasia Examination Aphasia Severity Rating Scale (BDAE-ASRS), and related neuropsychological impairments. Among the 100 stroke patients, 48 exhibited at least mild aphasia based on the BDAE-ASRS. Spearman rank correlations revealed that greater language impairment severity was linked to poor performance in memory recall, executive functioning, verbal fluency, naming, and comprehension at both time points. However, it was not associated with reduced mood, depressive symptoms, or quality of life. Lesion–behavior correlations were strongest at the acute stage, particularly in the left frontal, insular, and temporal regions, indicating a left-lateralized structure–function relationship. This pattern weakened but remained evident for verbal memory and naming at 3 months. Correlation stability over time was moderate (<i>r</i>_<i>s</i> = 0.432), with strong associations between acute language impairment severity and neuropsychological deficits (<i>r</i>_<i>s</i> = 0.700–0.895). These findings highlight the broader cognitive impact of poststroke language impairment and its shared neuroanatomical substrates, emphasizing the importance of early lesion patterns in shaping recovery. Future research should continue to explore the neural mechanisms of aphasia to inform targeted and effective therapeutic interventions.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/3164442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Changes in Brain Volume and Magnetic Susceptibility Following CGRP Monoclonal Antibody Treatment in Patients With Migraine","authors":"Yuya Kano,&nbsp;Yuto Uchida,&nbsp;Hirohito Kan,&nbsp;Keita Sakurai,&nbsp;Haruto Shibata,&nbsp;Mitsuharu Yamamoto,&nbsp;Koji Takada,&nbsp;Takao Takeshima,&nbsp;Noriyuki Matsukawa","doi":"10.1155/ane/2670232","DOIUrl":"https://doi.org/10.1155/ane/2670232","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to evaluate cross-sectional and longitudinal changes in brain volume and magnetic susceptibility associated with treatment using calcitonin gene–related peptide monoclonal antibodies in patients with migraine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Calcitonin gene–related peptide monoclonal antibodies are effective in migraine prevention. However, because their primary action is peripheral, the extent of their influence on the central nervous system remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-eight patients with migraine (18 responders and 10 nonresponders) underwent magnetic resonance imaging before and 6 months after treatment. Voxel-based analyses were performed using three-dimensional T1-weighted images and quantitative susceptibility mapping to assess brain volume and magnetic susceptibility, respectively. Cross-sectional analyses compared responders and nonresponders at each time point, whereas longitudinal analyses used subtraction images to evaluate alterations between pre- and post-treatment conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Cross-sectional analyses revealed no significant differences in brain volume or magnetic susceptibility between responders and nonresponders at either time point. Longitudinal morphometric analyses did not identify correction-surviving changes in gray matter volume or cortical thickness. At an exploratory voxel-level threshold, responders showed a greater longitudinal increase in magnetic susceptibility than nonresponders in the right calcarine sulcus extending into the visual association cortex (<i>T</i> = 4.24; MNI coordinates: <i>x</i> = 28, <i>y</i> = −68, <i>z</i> = 9), although this finding did not survive correction for multiple comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Calcitonin gene–related peptide monoclonal antibody treatment was not associated with correction-surviving structural morphometric changes over 6 months. An exploratory right calcarine susceptibility finding was observed in clinical responders, but its clinical significance remains unclear. These findings should be considered preliminary and require validation in larger longitudinal studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2670232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychometric Properties of the Dubousset Functional Test in Patients With Lumbar Spinal Stenosis","authors":"Tuba Unver,&nbsp;Bayram Unver,&nbsp;Kevser Sevik Kacmaz","doi":"10.1155/ane/3286680","DOIUrl":"https://doi.org/10.1155/ane/3286680","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lumbar spinal stenosis (LSS) may deteriorate the spinal structure and mobility, leading to various problems, including pain, fatigue, decreased physical function, gait and balance issues, and diminished quality of life. The Dubousset Functional Test (DFT) comprehensively evaluates the functional capacity of the spinopelvic muscle groups, gait, balance, and dual-tasking performance. This study evaluates the reliability and validity of the DFT in patients with LSS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The DFT was performed twice per day at 1-h intervals in 30 patients with LSS. Before and after the tests, the patient′s pain was assessed using the Visual Analog Scale. The intraclass correlation coefficient (ICC [2,1]), Bland–Altman analysis, standard error of measurement (SEM95), and smallest detectable change (SDC95) were calculated at a 95% confidence level to determine interrater reliability. Concurrent validity was examined using the five-repetition sit-to-stand test (5R-STS) and the Oswestry Disability Index (ODI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of the patients was 55.0 ± 9.4 years, and the DFT score was 47.6 ± 3.3 s. The DFT has an acceptable reliability point estimate (ICC: 0.65–0.87). The DFT total score showed moderate correlations with the 5R-STS (<i>r</i> = 0.50) and ODI (<i>r</i> = 0.46), providing limited evidence of concurrent validity for lower-extremity functional performance and self-reported disability. The SEM95 was 2.46, and the SDC95 was 6.84. No increased pain or side effects were observed due to the DFT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The DFT demonstrated acceptable reliability under the repeated-trial conditions used in this study, although the precision of the total-score reliability estimate was limited. The DFT showed preliminary concurrent validity in relation to sit-to-stand performance and self-reported disability in patients with LSS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/3286680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden Cognitive Deficits in Young Stroke Survivors With Excellent Functional Recovery: A Case-Control Study","authors":"Hedvig Lillo,&nbsp;Margus Ennok,&nbsp;Riina Vibo,&nbsp;Aire Raidvee,&nbsp;Janika Kõrv","doi":"10.1155/ane/6777302","DOIUrl":"https://doi.org/10.1155/ane/6777302","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Cognitive dysfunction is relatively common among younger stroke survivors, even in cases where physical recovery appears favorable. However, existing research often lacks methodological rigor, particularly in terms of comprehensive neuropsychological assessment within a well-controlled cohort. The present study is aimed at addressing this gap by assessing cognitive functioning in a clinically recovered group of younger stroke survivors using in-depth evaluation methods at a time point when spontaneous recovery is expected to have stabilized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants and Methods</h3>\u0000 \u0000 <p>We compared the cognitive performance of 20 working-age stroke survivors (mean age 47.7, SD = 6.3), who had experienced a relatively mild ischemic stroke (median NIHSS 3; IQR 2–5) located in the middle cerebral artery (MCA) territory, to 20 healthy controls matched for age, sex, and education. Time since stroke was a median of 2 years (IQR 1–3.25). All participants underwent a comprehensive neuropsychological assessment covering most functionally relevant cognitive domains.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Stroke survivors showed significantly poorer performance than controls in verbal learning and recall, simple attentional processing, and processing speed, as well as in most tests measuring executive functions. Analysis of individual profiles showed that cognitive dysfunction was present in nearly half of the stroke survivors, with notable variability in the severity of impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion and Conclusion</h3>\u0000 \u0000 <p>Despite excellent functional recovery and a high rate of return to work, stroke survivors performed noticeably worse than controls across several functionally important cognitive domains even years after a relatively mild stroke. While more severe dysfunction was evident in only a minority, subtle deficits may still impact daily functioning depending on individual life demands. These findings underscore the importance of recognizing potential cognitive difficulties after mild stroke and highlight the value of comprehensive neuropsychological assessment to provide targeted support.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/6777302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L5 Radiculopathy May Induce Changes in Sensory Perception in the Neighboring, Unaffected S1 Dermatome: A Case Control Study","authors":"Julia Emde,&nbsp;Theda Hansen,&nbsp;Malgorzata Kolodziej,&nbsp;Anne Schänzer,&nbsp;Frank Birklein,&nbsp;Christian Geber,&nbsp;Heidrun H. Krämer","doi":"10.1155/ane/7872571","DOIUrl":"https://doi.org/10.1155/ane/7872571","url":null,"abstract":"<p>Neuropathic pain from affection of single nerve roots regularly expands to the neighboring dermatomes. In this study, we aimed to investigate the psychophysical consequences of this pain spread. We performed quantitative sensory testing (QST) in 10 patients with disc herniation—related L5 radiculopathy (four women; age 56.9 ± 2.9 years) and 12 healthy controls (six women; age 55.9 ± 2.7 years) bilaterally in the L5 and S1 dermatomes. Average time between onset of pain and study inclusion was 32 days (+/−6.6). Pain intensity was rated as visual analog scale (VAS) (0–10) 6.5+/−0.6. Affection of the L5 nerve root was verified via clinical investigation, MRI and paravertebral needle electromyography (EMG). The cold (<i>F</i> = 8.158; <i>p</i> = 0.011) and warm detection (<i>F</i> = 13.636; <i>p</i> = 0.02) thresholds were higher within the affected L5 dermatome in nucleus pulposus prolapse (NPP) patients compared with controls, and for warm detection also compared with the contralateral side (<i>p</i> = 0.021). Hyperalgesia to blunt pressure was detected on the affected side in NPP patients compared with controls (<i>F</i> = 5.664; <i>p</i> = 0.029) and to the contralateral leg (<i>p</i> = 0.011). Comparing L5 and S1 dermatomes on the affected side, only functional hypoesthesia measure via mechanical detection threshold was increased within the impaired L5 dermatome (<i>p</i> = 0.043). In the neighboring S1 dermatomes, the warm detection thresholds were significantly increased on the affected side compared with the controls (<i>F</i> = 14.471; <i>p</i> = 0.001) and to the contralateral unaffected limb (<i>p</i> = 0.039). In conclusion, unilateral symptomatic L5 damage affects sensory perception in unaffected neighboring dermatomes on the affected limb.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/7872571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of Exposure to Neuroendovascular Intervention During Neurology Training in LATAM: An International Multicenter Exploratory Survey and Review of the Literature","authors":"Miguel A. Vences,&nbsp;Rodrigo Dècima,&nbsp;Virgilio E. Failoc- Rojas,&nbsp;Joel M. Sequeiros","doi":"10.1155/ane/2748952","DOIUrl":"https://doi.org/10.1155/ane/2748952","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim is to assess the exposure to neuroendovascular intervention and perceptions among trainees in Latin America.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A descriptive and cross-sectional study was conducted from October to December 2024 and was aimed at neurology residents and/or fellows in Latin American hospitals. An electronic questionnaire was conducted on the Google Forms platform. Prior to applying the instrument, it was subjected to content and appearance validation. The survey was sent up to three times by email to avoid a low response rate. The information was then transferred to a database without identifiers, ensuring the anonymity and confidentiality of the information.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 83 surveys were collected from respondents across 16 Latin American countries. The majority were senior neurology residents (75.9%). Around one-third (34.9%) expressed interest in pursuing future training in neuroendovascular intervention. Among those considering further training, only 19.7% would do so in their current institution, while 55.7% would prefer another Latin American country. Regarding leadership of the endovascular unit, 38.8% were led by neurologists, 31.3% by neurosurgeons, and 26.9% by radiologists. In 75% of units, at least one interventional neurologist was present. Over 80% believed that a formal rotation in neuroendovascular intervention would improve their overall training. However, only 17.8% anticipated they would encounter no major obstacles in pursuing a career in neurointervention. Among the most perceived barriers were a lack of logistical resources such as devices and consumables (37.3%), resistance from other specialties like neurosurgery and radiology (31.0%), and underprepared healthcare systems that hinder the development of neurointerventional services (28.9%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Most trainees consider that neuroendovascular exposure needs to be part of the curriculum of contemporary neurology residency programs in Latin America. More exposure will probably positively impact their perception of training and increase their interest in pursuing a subspecialization in the field.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2748952","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Determinants of Poststroke Fatigue in Patients Treated With Acute Revascularization Therapy","authors":"Ramen Munir Baloch,&nbsp;Yannick Béjot","doi":"10.1155/ane/1432436","DOIUrl":"https://doi.org/10.1155/ane/1432436","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Fatigue adversely affects quality of life after stroke. This study is aimed at assessing the prevalence of poststroke fatigue at 6 months and its determinants in patients with acute ischemic stroke treated with revascularization therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Consecutive ischemic stroke patients treated with intravenous thrombolysis and/or mechanical thrombectomy were enrolled. Sociodemographic, clinical, and ischemic lesion characteristics were collected at baseline. Fatigue was assessed at 6-month follow-up using the Fatigue Severity Scale (FSS), along with functional outcome, anxiety, and depression. Factors associated with poststroke fatigue were evaluated in the overall cohort and in patients with supratentorial hemispheric stroke using logistic regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 900 enrolled patients, 413 survivors had available fatigue assessment (mean age: 69.2 ± 14.1 years, 52.3% men, median NIHSS score: 9 [IQR: 5–15]). Poststroke fatigue (FSS score ≥ 36) was observed in 161 patients (39%). In the overall cohort, fatigue was independently associated with depression (OR = 5.78, 95% CI: 2.68–12.4) and anxiety (OR = 2.90, 95% CI: 1.52–5.51), whereas being single was negatively associated with fatigue (OR = 0.30, 95% CI: 0.09–0.99). A marginal association was observed with cerebellar stroke location (OR = 11.0, 95% CI: 0.88–137.6). In patients with supratentorial hemispheric stroke, fatigue was independently associated with hypertension (OR = 2.25, 95% CI: 1.13–4.47), right-sided lesion (OR = 2.08, 95% CI: 1.13–3.83), depression (OR = 5.35, 95% CI: 2.08–13.7), and anxiety (OR = 3.10, 95% CI: 1.42–6.74).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Poststroke fatigue remains a frequent and clinically meaningful outcome in patients with ischemic stroke treated with revascularization therapy and is strongly associated with psychological factors and right hemispheric location. Whether specific therapeutic interventions may reduce the burden of this symptom warrants further investigation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT02856074</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/1432436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Treatment in Patients With Acute Ischemic Stroke and Intracranial Stenting: A Cohort Study of EVA-TRISP Collaboration","authors":"Maria Girfanova,&nbsp;Paul J. Nederkoorn,&nbsp;Gerli Sibolt,&nbsp;Nicolas Martinez-Majander,&nbsp;Kateryna Antonenko,&nbsp;Mirjam R. Heldner,&nbsp;Tomas Dobrocky,&nbsp;Eike I. Piechowiak,&nbsp;Marcel Arnold,&nbsp;Malin Woock,&nbsp;Katarina Jood,&nbsp;Alexandros Rentzos,&nbsp;Nabila Wali,&nbsp;Jonathan M. Coutinho,&nbsp;Lukas Otto,&nbsp;Anton Schmick,&nbsp;Susanne Wegener,&nbsp;Alexander Salerno,&nbsp;Davide Strambo,&nbsp;Patrik Michel,&nbsp;Gian Marco De Marchis,&nbsp;Tolga Dittrich,&nbsp;Henrik Gensicke,&nbsp;Stefan T. Engelter,&nbsp;Simon Trüssel,&nbsp;Marios Psychogios,&nbsp;Guido Bigliardi,&nbsp;Gabriele Vandelli,&nbsp;Christoph Riegler,&nbsp;Christian H. Nolte,&nbsp;João Pedro Marto,&nbsp;Inês Carmo e Pinto,&nbsp;Andrea Zini,&nbsp;Matteo Paolucci,&nbsp;Carlo W. Cereda,&nbsp;Giovanni Bianco,&nbsp;Alessandro Pezzini,&nbsp;Mauro Magoni,&nbsp;Ronen R. Leker,&nbsp;Visnja Padjen,&nbsp;Sami Curtze","doi":"10.1155/ane/6300825","DOIUrl":"https://doi.org/10.1155/ane/6300825","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Ischemic stroke is a major global cause of disability and death. Although clot-removing endovascular treatment (EVT) is the standard treatment for large vessel occlusion, the additional benefit of permanent intracranial stenting during EVT remains uncertain. This study is aimed at comparing outcomes between patients treated with EVT alone and those who also received a permanent stent, focusing on a predominantly Caucasian population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and methods</h3>\u0000 \u0000 <p>We analyzed data from 14,435 stroke patients treated with EVT across 16 comprehensive stroke centers in the EVA-TRISP collaboration. Among them, 386 patients received a permanent intracranial stent. Functional outcomes at 3 months and the occurrence of fatal and symptomatic intracerebral hemorrhage (ICH) were evaluated using ECASS II/III criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Stent placement was not initially associated with worse functional outcome in univariable analysis (OR 1.19, 95% CI 0.98–1.43). However, stent placement was associated with worse prognosis after adjusting for age, sex, comorbidities, and Prior IV thrombolysis (OR 1.36, 95% CI 1.13–1.67). There were no significant differences in symptomatic, fatal ICH or 3-month mortality between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Patients treated with EVT alone had better functional recovery and less disability at 3 months. However, the reason for stenting was not documented for this cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this multicenter cohort, EVT alone was associated with better functional outcomes than EVT with stenting. Further randomized studies are needed to identify patients who may benefit from stenting.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/6300825","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}