Acta Neurologica Scandinavica最新文献

{"title":"Targeting the Hippocampal CA1 in Older Adults: A Simulation Study of Low-Intensity Transcranial Ultrasound Stimulation","authors":"Kaipeng Wang,&nbsp;Yuke Luo,&nbsp;Zeyan Li,&nbsp;Liwei Guo,&nbsp;Lin Meng,&nbsp;Yi Yuan,&nbsp;Yan Shao,&nbsp;Hanna Lu","doi":"10.1155/ane/5678239","DOIUrl":"https://doi.org/10.1155/ane/5678239","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Low-intensity transcranial ultrasound stimulation (TUS) is an advanced noninvasive neuromodulation technique with great clinical potential. The hippocampal cornu ammonis 1 (CA1) is a crucial subfield for higher cognitive functions, such as memory formation, and is integrally involved in sleep-dependent memory consolidation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study sought to establish computational models for low-intensity TUS targeting the bilateral CA1 and to analyze the simulation parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We recruited eight young adults (mean age: 25.75 years) and 10 cognitively unimpaired older adults (mean age: 68.98 years). Based on T1-weighted magnetic resonance imaging (MRI) data, bilateral CA1 volumes were segmented and quantified for target localization. We constructed a simulation model on the k-Plan platform for low-intensity TUS delivered to the bilateral CA1 through the lateral pathway. Hemispheric-specific focal distance, spatial-peak pulse-average intensity (ISPPA), maximum temperature change (<i>Δ</i><i>T</i>), and mechanical index (MI) were compared between age groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with young adults, older adults showed significantly shorter focal distance (<i>t</i> = 3.61, <i>p</i> = 0.003), higher in situ ISPPA (<i>t</i> = −4.38, <i>p</i> = 0.001), higher maximum <i>Δ</i><i>T</i> (<i>t</i> = −6.50, <i>p</i> &lt; 0.001), and higher MI (<i>t</i> = −3.40, <i>p</i> = 0.008) induced by low-intensity TUS targeting right CA1. A significant hemispheric difference in focal distance was observed exclusively in older adults, with the left CA1 exhibiting a longer focal distance than the right side (<i>t</i> = 2.34, <i>p</i> = 0.044). Correlation analyses incorporating volumetric data further revealed different age-related patterns across two age groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study evaluates the age- and hemisphere-related differences in low-intensity TUS simulations targeting the bilateral CA1 in young and older adults. These findings provide important guidance for the clinical translation of low-intensity TUS in the aging population and the development of personalized therapeutic protocols.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/5678239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Approach for Screening of Hypoglycemia-Associated Autonomic Failure Using c-FOS and Beclin-1: A Cross-Sectional Study","authors":"Salwa Bader,&nbsp;Alizeh Ashfaq,&nbsp;Bashair M. Mussa,&nbsp;Fatheya Al Awadi,&nbsp;Poorna Manasa Bhamidimarri,&nbsp;Zainab Al-Abadla,&nbsp;Salah Abusnana","doi":"10.1155/ane/6400429","DOIUrl":"https://doi.org/10.1155/ane/6400429","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Iatrogenic hypoglycemia remains a major obstacle to achieving optimal glycemic control in Type 1 diabetes mellitus (T1DM). Recurrent hypoglycemia leads to defective glucose counterregulatory response and impaired awareness of hypoglycemia—key features of hypoglycemia-associated autonomic failure (HAAF). This study is aimed at identifying novel biomarkers for HAAF screening and assess the clinical characteristics of hypoglycemia among T1DM patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted at the Diabetes and Endocrinology Clinics of the University Hospital Sharjah, Al Qassimi Hospital, and Dubai Hospital, involving 75 adults with T1DM (aged 18–60 years). Participants were categorized into three groups: no evidence of hypoglycemia (25.3%, <i>n</i> = 19), hypoglycemia awareness (34.7%, <i>n</i> = 26), and hypoglycemia unawareness (40%, <i>n</i> = 30). Hypoglycemia status, frequency, and severity were evaluated using the Hypoglycemia Awareness Questionnaire. Blood samples were analyzed for cFOS and Beclin-1 gene expression using <i>Δ</i>Ct values, where higher <i>Δ</i>Ct indicates lower expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Beclin-1 expression was significantly higher in the hypoglycemia unawareness group (<i>Δ</i>Ct 1.58 ± 2.29) compared with the awareness group (<i>Δ</i>Ct 2.29 ± 0.93; <i>p</i> &lt; 0.0001). Conversely, cFOS expression was higher in the awareness group (<i>Δ</i>Ct 14.77 ± 1.97) than in the unawareness (<i>Δ</i>Ct 24.63 ± 4.56; <i>p</i> &lt; 0.0001) and no-hypoglycemia groups (<i>Δ</i>Ct 28.19 ± 3.13; <i>p</i> &lt; 0.0001). Impaired hypoglycemia awareness was significantly associated with older age (<i>p</i> = 0.032), longer diabetes duration (<i>p</i> = 0.025), lower HbA1c (<i>p</i> = 0.006), reduced heart rate (<i>p</i> = 0.006), lower triglycerides (<i>p</i> = 0.01), and recurrent hypoglycemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>cFOS and Beclin-1 may serve as potential biomarkers for HAAF, reflecting distinct molecular and clinical profiles in T1DM patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/6400429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Prognostic Value of Plasma NfL and Creatinine in a Korean Cohort of Amyotrophic Lateral Sclerosis and Spinal and Bulbar Muscular Atrophy: A Cross-Sectional Study","authors":"Shinrye Lee,&nbsp;Youngtae Choi,&nbsp;Minsung Kang,&nbsp;Ho-Won Lee,&nbsp;Hyung-Jun Kim,&nbsp;Jin-Sung Park,&nbsp;Mookyung Cheon","doi":"10.1155/ane/8892421","DOIUrl":"https://doi.org/10.1155/ane/8892421","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Biomarkers that can distinguish motor neuron disease spectrum conditions, such as spinal and bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), could facilitate early-stage diagnosis. This study used a multibiomarker approach to improve the differential diagnosis between SBMA and ALS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, plasma samples were collected from patients with SBMA (<i>n</i> = 44), male patients with ALS (<i>n</i> = 26), and healthy controls (<i>n</i> = 20). Plasma levels of neurofilament light chain (NfL), creatine (Cr), and Cr kinase (CK) were measured. Disease severity was assessed using the Revised ALS Functional Rating Scale scores and its subscores in both patient groups. Additionally, SBMA-specific functional measures, including SBMA Functional Rating Scale (SBMAFRS) scores and the 6-Min Walk Test (6MWT), were evaluated in patients with SBMA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NfL levels were significantly higher in patients with ALS than in patients with SBMA and healthy controls, and were significantly influenced by age. When the three biomarkers were entered into logistic regression models, NfL levels alone could be used to differentiate ALS from SBMA almost perfectly, and the inclusion of Cr or CK levels did not improve this differentiation. Within the SBMA group, however, Cr levels were correlated with the lower-limb subscore of the SBMAFRS and with 6MWT results, which points to a role in tracking motor function rather than in diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results indicated that plasma NfL levels could be used to reliably distinguish ALS from SBMA, whereas plasma Cr levels were better suited as a marker of muscle function and disease severity in SBMA. Measuring both of these may therefore aid diagnosis as well as prognostic assessment in patients with suspected motor neuron disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/8892421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes and Rehabilitation Requirements in Guillain–Barré Syndrome: An 18-Year Experience From a Neurological Center in Argentina","authors":"José M. Pastor Rueda,&nbsp;Lucas Alessandro,&nbsp;Agustín Puebla,&nbsp;Ricardo Kirchner,&nbsp;Christian Gath,&nbsp;Fabio Barroso","doi":"10.1155/ane/1165580","DOIUrl":"https://doi.org/10.1155/ane/1165580","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objectives</h3>\u0000 \u0000 <p>Guillain–Barré syndrome is the most common cause of acute acquired neuromuscular paralysis worldwide and is frequently associated with significant disability requiring rehabilitation. However, data on rehabilitation requirements and their clinical predictors remain limited, particularly in low- and middle-income countries. We aimed to characterize rehabilitation requirements and identify associated clinical factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective observational cohort study including adult patients with Guillain–Barré syndrome diagnosed between 2006 and 2023 at a neurological center in Argentina with at least 1 year of follow-up. Demographic data, clinical features, electrophysiological findings, treatments, intensive care requirements, and functional outcomes were analyzed. Motor impairment was assessed using the Medical Research Council sum–score and disability using the Guillain–Barré syndrome disability scale. Patients were classified according to rehabilitation requirements (none, outpatient, or inpatient).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 142 screened patients, 114 were included (median age 48 years; 43.9% female). Forty patients required no rehabilitation, 62 outpatient rehabilitation, and 12 inpatient rehabilitation. Lower Medical Research Council sum–scores, sensory ataxia, abnormal osteotendinous reflexes, severe autonomic dysfunction, and unilateral facial palsy were associated with rehabilitation requirements. Intensive care unit admission, mechanical ventilation, hemodynamic support, disability score ≥ 3 at discharge, and lower Medical Research Council scores at discharge were also associated with rehabilitation requirements. No significant differences were observed among electrophysiological subtypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Rehabilitation requirements in Guillain–Barré syndrome are mainly driven by early clinical severity, autonomic and respiratory involvement, and residual motor disability at discharge. Early identification of these factors may facilitate timely referral to rehabilitation programs and improve functional recovery. These findings may support early stratification of patients and optimize rehabilitation referral in routine clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/1165580","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Time to Intravenous Thrombolysis in Ischemic Stroke Patients With NIHSS Score 0–2 at Admission","authors":"Torunn Varmdal,&nbsp;Martin André Blindheimsvik,&nbsp;Stian Lydersen,&nbsp;Hild Fjærtoft,&nbsp;Bent Indredavik","doi":"10.1155/ane/2042787","DOIUrl":"https://doi.org/10.1155/ane/2042787","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There is rising evidence that intravenous thrombolysis (IVT) in stroke patients presenting with mild neurological deficits may not be beneficial. However, there is limited knowledge on time to IVT treatment in relation to functional outcome in this population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The aim of the study is to examine the effect of time to IVT treatment in a real-world setting among patients with a National Institutes of Health Stroke Scale (NIHSS) score of 0–2 at admission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This observational study included ischemic stroke patients registered in the NHR in 2014-2022. We categorized patients into four groups: no IVT, or IVT within 90, 91–180, or &gt; 180 min after symptom onset. Functional outcome 3 months post stroke was compared across groups using ordinal logistic regression, with outcomes measured by modified Rankin Scale (mRS). Missing values were handled using multiple imputation, and our primary analysis was performed on a recombined dataset of 40 imputed datasets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results are presented as the pooled odds across 40 imputed datasets (mean <i>n</i> = 7722). The odds of having a higher mRS score 3 months post stroke (i.e., a worse outcome) was 0.81 (95% CI 0.71–0.92) for patients receiving IVT within 90 min after symptom onset, increasing to 0.90 (CI 0.80–1.02) for IVT between 91 and 180 min, and 0.98 (CI 0.85–1.13) for IVT &gt; 180 min after symptom onset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>When administered within 90 min of stroke onset, IVT treatment is associated with beneficial functional outcome for stroke patients presenting with NIHSS 0–2. However, the favorable effect of IVT appears to diminish progressively with increasing time from symptom onset. In our cohort, 3.2% of patients treated with IVT experienced symptomatic intracranial hemorrhage (sICH). Careful consideration of the risk-benefit ratio is advised before administering IVT for patients with mild neurological deficits, particularly in those presenting more than 90 min after stroke onset.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/2042787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients′ Experience of a Migraine Patients′ School using a Multimodal Behavioural Treatment Approach—A Qualitative Pilot Study","authors":"Kerstin Hedborg,&nbsp;Birgitta Helmerson,&nbsp;Elisabet Waldenlind,&nbsp;A. Ingela M. Nilsson Remahl,&nbsp;Anna Sundholm","doi":"10.1155/ane/9940154","DOIUrl":"https://doi.org/10.1155/ane/9940154","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>High frequency/chronic migraine is a disabling pain disorder requiring both pharmacological and nonpharmacological strategies. Although multimodal behaviour approaches are increasingly used, there is limited qualitative research exploring patients′ perceived experience of participating in such interventions. We implemented a migraine patients′ school (MPS) based on the hypothesis that well-informed patients can better self-manage their migraine disorder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study is aimed at exploring how patients with severe migraine perceived their experiences of participating in the intervention MPS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients attending the MPS at the Department of Neurology, Karolinska University Hospital, Sweden during the period 2014–2015 were invited to an interview evaluation of the programme 12 weeks after completion of the intervention. The MPS consisted of a multimodal behavioural intervention combined with migraine education and physiotherapy with applied relaxation and Basic Body Awareness Therapy (BBAT). Semistructured group interviews (three to four participants per interview group) were audio-recorded, transcribed verbatim, and analysed using inductive content analysis to capture experiences of both the programme components and the programme as a whole.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 24 participants, 10 completed the MPS agreed to be interviewed. The interviews identified three subthemes and eight categories: physical aspects (body awareness, relaxation, physical activity), mental aspects (emotional balance, thought patterns, self-compassion), and interactions with family and colleagues.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Participants described gaining new perspectives, strategies, and a sense of hope from the MPS. This exploratory qualitative study highlights patient experiences that may guide the future development and evaluation of multimodal behavioural programmes for migraine. Such interventions may help patients handle their condition, improve their life situation and make more informed decisions regarding their migraine.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/9940154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148615928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Disease Burden Estimate of Epilepsy Without Specific Cause in Colombia From 2015 to 2020","authors":"Diana Fernanda Bejarano-Ramírez,&nbsp;Tatiana Roldán-Ovalle,&nbsp;Daniel Felipe Rangel-Rueda,&nbsp;Luis Carlos Mayor","doi":"10.1155/ane/9433232","DOIUrl":"https://doi.org/10.1155/ane/9433232","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Epilepsy is a major neurological disorder with significant health and social implications. Understanding its burden is essential for guiding public health strategies in Colombia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To estimate the disease burden expressed in disability-adjusted life years (DALYs) associated with epilepsy without a specific cause in Colombia from 2015 to 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted using data from the Individual Service Provision Registry (RIPS) and mortality records from the National Administrative Department of Statistics (DANE). DALYs were calculated as the sum of years of life lost (YLL) due to premature mortality and years lived with disability (YLD), applying disability weights from the Global Burden of Disease study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2015 and 2020, epilepsy accounted for 50,769 DALYs (102.4 per 100,000 inhabitants). Premature mortality represented 82% of the burden, while disability contributed 18%. Men accounted for 57% of DALYs, and the highest burden occurred in individuals aged 60 years and older.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Epilepsy imposes a substantial health burden in Colombia, primarily driven by premature mortality. These findings underscore the need for public health policies focused on early diagnosis, timely treatment, and equitable access to care. Strategies should also address stigma reduction and resource allocation to improve outcomes and reduce YLL.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/9433232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148615633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Self-Reported Depression During the First Year After Stroke: A Register-Based Study","authors":"John E. Wallman,&nbsp;Malin Reinholdsson,&nbsp;Katharina S. Sunnerhagen","doi":"10.1155/ane/4508526","DOIUrl":"https://doi.org/10.1155/ane/4508526","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The most common neuropsychiatric complication of stroke is poststroke depression, affecting around one-third of stroke survivors. Research varies on how poststroke depression changes over time and less is known about the course of self-reported depression in a Swedish population. The aim was therefore to investigate how self-reported poststroke depression changes between 3 and 12 months after stroke in a Swedish registry-based cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This longitudinal study included registry-based data from quality registers Riksstroke and Väststroke. The study included 3269 patients admitted to three stroke units at the Sahlgrenska University Hospital in Gothenburg, Sweden between November 1, 2014 and December 31, 2019. The change in self-reported depression, measured on a 1–4 scale, was statistically analyzed using the McNemar–Bowker test and presented using descriptive statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study sample had a median age of 74 years, with 45% females. Three months after stroke, 57% reported depression, with a significant increase at 12 months to 63% (<i>p</i> &lt; 0.001). About 62% reported no change in depression score, but 27% reported an increase in depression score, and 16% reported a decrease. Approximately 32% of patients who did not report depression at 3 months reported depression after 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results show that many patients who could benefit from treatment are not being identified during stroke follow-up. Future studies could investigate self-reported depression over a longer period to better understand how poststroke depression evolves, as well as investigate factors associated with changes in poststroke depression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/4508526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148615634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Remote Ischemic Conditioning for Moyamoya Disease: A Meta-Analysis of Randomized Controlled Trials","authors":"Xiaohong Zheng,&nbsp;Hongliang Liu,&nbsp;Jing Zheng,&nbsp;Xiaojie Li,&nbsp;Yanmei Zu,&nbsp;Tianqi Zhou,&nbsp;Dongmei Li,&nbsp;Jianmin Liu,&nbsp;Li Xu","doi":"10.1155/ane/4660621","DOIUrl":"https://doi.org/10.1155/ane/4660621","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Remote ischemic conditioning (RIC) is a noninvasive, transient procedure that induces brief ischemia and reperfusion. Currently, an assessment of its efficacy in treating moyamoya disease (MMD) remains lacking. This meta-analysis synthesized data from existing randomized controlled trials (RCTs) to estimate the efficacy of RIC in MMD patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Embase, PubMed, Wanfang, Cochrane Library, Web of Science, Scopus, and CNKI were comprehensively searched from database inception to May 8, 2026. The Cochrane risk of bias tool was used to assess the quality of the included RCTs. Statistical analyses were carried out using Review Manager Version 5.4.1.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>RIC was associated with a lower incidence of ischemic stroke in patients with MMD (<i>n</i> = 228, OR: 0.22, 95% CI: 0.07–0.67, <i>p</i> = 0.008). No significant reduction was observed in the incidence of transient ischemic attacks (TIA) (<i>n</i> = 184, OR: 0.73, 95% CI: 0.36–1.47, <i>p</i> = 0.38), CHS (<i>n</i> = 152, OR: 0.28, 95% CI: 0.07–1.12, <i>p</i> = 0.07), or seizures (<i>n</i> = 152, OR: 0.26, 95% CI: 0.04–1.62, <i>p</i> = 0.15).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RIC may have potential neuroprotective effects in patients with MMD, particularly regarding ischemic stroke. However, the current evidence remains limited by small sample sizes, sparse events, and substantial heterogeneity. Further adequately powered multicenter RCTs are required to confirm these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/4660621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148615505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Norwegian NBSS-SF: Psychometric Properties in People With Multiple Sclerosis Treated With Natalizumab","authors":"Harald Myklebust,&nbsp;Erik Grønnestad,&nbsp;Geoffrey Peel,&nbsp;Heidi Øyen Flemmen,&nbsp;Kamilla Brekke,&nbsp;Line Broch,&nbsp;Cathrine Brunborg,&nbsp;Elisabeth Gulowsen Celius,&nbsp;Cecilia Smith Simonsen","doi":"10.1155/ane/7868813","DOIUrl":"https://doi.org/10.1155/ane/7868813","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Neurogenic lower urinary tract dysfunction (NLUTD) is common in neurological disease. Patient reported outcome measures (PROMs) can be useful for evaluating NLUTD and are recommended by guidelines. The Neurogenic Bladder Symptom Score–Short form (NBSS-SF) is a 10-item questionnaire that measures symptom burden and bladder-related quality of life due to NLUTD. The aim of this study is to translate and validate the Norwegian version of the NBSS-SF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The translation of the NBSS-SF was done in accordance with international guidelines for cross-cultural adaptation of questionnaires. Ten people with multiple sclerosis (pwMS) pilot-tested the pre-final version and the final version was made.</p>\u0000 \u0000 <p>We assessed the psychometric properties of the Norwegian NBSS-SF in pwMS treated with natalizumab (NTZ). They completed the Norwegian NBSS-SF and International Prostate Symptom Score (IPSS) at baseline and repeated the NBSS-SF at second visit. Patient data was gathered from health records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 69 pwMS were recruited. Mean age was 46.7 years (SD 11.6), median disease duration of 10 years, and median Expanded Disability Status Scale score (EDSS) of 2.0 (range 0–8). Median NBSS-SF-score was 4 (range 1–19). There was good correlation (<i>S</i><i>p</i><i>e</i><i>a</i><i>r</i><i>m</i><i>a</i><i>n</i>^’<i>s</i> <i>r</i><i>h</i><i>o</i> = 0.51, <i>p</i> &lt; 0.001) between NBSS-SF and IPSS. NBSS-SF-score correlated with EDSS (<i>S</i><i>p</i><i>e</i><i>a</i><i>r</i><i>m</i><i>a</i><i>n</i>^’<i>s</i> <i>r</i><i>h</i><i>o</i> = 0.46). Patients treated for NLUTD had higher scores (<i>p</i> &lt; 0.001). The Norwegian NBSS-SF has good internal consistency (<i>C</i><i>r</i><i>o</i><i>n</i><i>b</i><i>a</i><i>c</i><i>h</i>^’<i>s</i> <i>a</i><i>l</i><i>p</i><i>h</i><i>a</i> = 0.88) and test–retest reliability (<i>i</i><i>n</i><i>t</i><i>r</i><i>a</i><i>c</i><i>l</i><i>a</i><i>s</i><i>s</i> <i>c</i><i>o</i><i>r</i><i>r</i><i>e</i><i>l</i><i>a</i><i>t</i><i>i</i><i>o</i><i>n</i> <i>c</i><i>o</i><i>e</i><i>f</i><i>f</i><i>i</i><i>c</i><i>i</i><i>e</i><i>n</i><i>t</i> = 0.88).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The Norwegian NBSS-SF proved valid and reliable for measuring symptoms of NLUTD in a cohort of pwMS treated with NTZ.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2026 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/7868813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}