Acta Neurologica Scandinavica最新文献

{"title":"Pathological Spontaneous Activity in Different Thoracic Paraspinal Muscles in Amyotrophic Lateral Sclerosis","authors":"Yuting Ren,&nbsp;Na Chen,&nbsp;Kang Zhang,&nbsp;Bin Chen,&nbsp;Songtao Niu,&nbsp;Xingao Wang,&nbsp;Fan Jian,&nbsp;Zaiqiang Zhang,&nbsp;Hua Pan","doi":"10.1155/2024/7102913","DOIUrl":"https://doi.org/10.1155/2024/7102913","url":null,"abstract":"<p><b>Objective:</b> The aim of our study was to compare the clinical value of pathological spontaneous activity (PSA) in different thoracic paraspinal muscles (TPMs) in amyotrophic lateral sclerosis (ALS).</p><p><b>Methods:</b> A total of 116 ALS patients were retrospectively analyzed over 31 ± 8 months concerning the occurrence of PSA in T9–T11 TPM. The occurrence of PSA was correlated with pulmonary function and clinical disability.</p><p><b>Results:</b> The positive sharp wave (PSW) potentials were more frequently observed than fibrillation (fib) in T9–T11 segments. The PSA positive frequency of bulbar-onset ALS (B-ALS) is less than upper limb-onset ALS (U-ALS) and lower limb-onset ALS (L-ALS) at the levels of T10 and T11 TPM (<i>p</i> = 0.050, <i>p</i> = 0.001). The fibs/PSWs in TPM indicated high sensitivity and negative predictive value for forced vital capacity (FVC) &lt; 80%. Linear correlation analysis indicated that PSA of TPM was associated with pulmonary ventilation function (PVF). Associations also exist between clinical parameters and PVF as well as the disease severity.</p><p><b>Conclusions:</b> The occurrence of T9-TPM fibs/PSWs was correlated with clinical disability and is extremely helpful in implying an involvement of PVF. The T9-TPM typically provided a good practical indicator for comprehensive disease evaluation, which was irrelevant to the site of onset.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7102913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142234813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Initial Corticosteroid Regimen and Treatment Response Time in Acetylcholine Receptor Antibody–Positive Myasthenia Gravis","authors":"Jinhee Kim,&nbsp;Hyung Jun Park,&nbsp;Seung Woo Kim,&nbsp;Ha Young Shin","doi":"10.1155/2024/1409983","DOIUrl":"https://doi.org/10.1155/2024/1409983","url":null,"abstract":"<p><b>Background:</b> Corticosteroids remain the cornerstone in the management of myasthenia gravis (MG). Initiation of corticosteroid treatment at a high dose and subsequently decreasing the dose or gradual escalation from a low dose is recommended. We aimed to investigate the association between the initial corticosteroid regimen and treatment response.</p><p><b>Methods:</b> A retrospective study was conducted on 234 acetylcholine receptor (AChR) antibody (Ab)–positive MG patients who visited our institution between January 2010 and February 2023. Patients were grouped based on prednisolone dosages received: initial high (IH, ≥50 mg/day) or initial low (IL, ≤20 mg/day). Time to initial improvement and the achievement of minimal manifestation (MM) status were the main outcomes.</p><p><b>Results:</b> Of the 234 patients, 135 were classified as IH and 99 as IL group. The IH group demonstrated a faster onset of improvement compared with the IL group (20.0 [16.0–29.0] vs. 40.0 [27.0–84.0] days), with the IH group being a significant prognostic factor for initial improvement (HR, 2.44; 95% CI, 1.76–3.39). However, the IH group had a higher incidence of steroid-induced exacerbation (51.9% vs. 2.0%, <i>p</i> &lt; 0.001). No significant difference between the IH and IL groups was found in terms of the proportion of patients achieving MM or the time to achieve MM within the first year after treatment initiation.</p><p><b>Conclusion:</b> While an initial high dose of corticosteroid treatment accelerated the onset of therapeutic responses in patients with AChR Ab–positive MG, it was associated with a higher cumulative steroid dose and an increased risk of steroid-induced exacerbations.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1409983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142165698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifiable Lifestyle Factors and Cognitive Function: A Population-Based Study Amongst Nondemented Men","authors":"Kayla B. Corney,&nbsp;Amanda L. Stuart,&nbsp;Mohammadreza Mohebbi,&nbsp;Julie A. Pasco,&nbsp;Bianca E. Kavanagh,&nbsp;Sophia X. Sui,&nbsp;Lana J. Williams","doi":"10.1155/2024/1935091","DOIUrl":"https://doi.org/10.1155/2024/1935091","url":null,"abstract":"<p><b>Background</b>: As cognitive decline and dementia-related diseases are currently incurable, identifying modifiable and preventative factors is imperative. Thus, we aimed to investigate the associations between modifiable lifestyle factors and cognitive function in a population-based sample of nondemented men.</p><p><b>Methods:</b> Data for 537 men were drawn from the ongoing, population-based, Geelong Osteoporosis Study (GOS). The CogState Brief Battery (CBB) was utilised to determine cognitive function (overall cognitive function [OCF], psychomotor function, attention, working memory, and visual learning). Demographic and lifestyle factors (diet, smoking, physical activity [sport, work/home, and leisure time], alcohol use, and body mass index [BMI]) were self-reported and documented across three waves of data collection. Generalised estimating equation (GEE) models were used to determine associations between the time-updating exposures of interest and each of the cognitive domains.</p><p><b>Results:</b> Age was associated with OCF (<i>η</i>² = 0.298), psychomotor function (<i>η</i>² = 0.163), attention (<i>η</i>² = 0.210), working memory (<i>η</i>² = 0.215), and visual learning (<i>η</i>² = 0.097). Playing sport was associated with all aspects of cognition: OCF (<i>η</i>² = 0.014), psychomotor function (<i>η</i>² = 0.007), attention (<i>η</i>² = 0.004), working memory (<i>η</i>² = 0.013), and visual learning (<i>η</i>² = 0.004), and being physically active during leisure time was associated with visual learning (<i>η</i>² = 0.008). Being physically active at work and home, smoking, diet quality, energy consumed per day, alcohol intake, and BMI were not associated with any of the cognitive domains.</p><p><b>Conclusion:</b> In this study of nondemented men, elements of a healthy lifestyle such as playing sport and being physically active during leisure time were associated with better cognition. Further studies into whether these factors, amongst others, prevent the onset and progression of dementia are needed.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1935091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota, Metabolites, Circulating Cytokines and Growth Factors, Plasma Proteins, and Risk of Intracranial Aneurysms: A Two-Sample Mendelian Randomization Study","authors":"Aierpati Maimaiti,&nbsp;Zhihao Xie,&nbsp;Mirzat Turhon,&nbsp;Alimasi Abulizi,&nbsp;Wenxuan Wang,&nbsp;Pengfei Wu,&nbsp;Qingyu Yang,&nbsp;Maimaitili Aisha,&nbsp;Zengliang Wang,&nbsp;Yongxin Wang","doi":"10.1155/2024/9764442","DOIUrl":"https://doi.org/10.1155/2024/9764442","url":null,"abstract":"<p><b>Background:</b> Increasing evidence implicates the gut microbiota, metabolites, circulating cytokines and growth factors, and plasma proteins as potential susceptibility factors for intracranial aneurysm (IA). However, due to their complexity, the causal relationship between these factors and IA remains unclear. Our goal was to determine whether these factors are causally associated with IA, UIA, and SAH and provide suggestions for the prevention and treatment of these cerebrovascular diseases.</p><p><b>Methods:</b> Utilizing data from genome-wide association studies (GWAS), we conducted a large-scale Mendelian randomization (MR) analysis between these factors and diseases using five different models (Wald ratio, IVW, MR-Egger, weighted median, and MRPRESSO). Several sensitivity analyses were also applied to ensure the robustness of the results.</p><p><b>Results:</b> Our MR analysis revealed several significant causal relationships between 18 gut microbiota taxa (genus.<i>Bilophila</i>-SAH, beta[95<i>%</i>CI] = −1.08[−1.61 ~ −0.54]), 55 blood metabolites (7-alpha-hydroxy-3-oxo-4-cholestenoate-IA, beta[95<i>%</i>CI] = −2.78[−4.47 ~ −1.08]), 2 cytokines (IL-6-UIA, beta[95<i>%</i>CI] = 0.73[0.34 ~ 1.39]), 45 plasma proteins (RELT-UIA, beta[95<i>%</i>CI] = −0.8[−1.22 ~ −0.38]), and IA, UIA, and SAH. Many of these were reported for the first time.</p><p><b>Conclusions:</b> In conclusion, our study provides reference of the potential causal effects of gut microbiota, blood metabolites, cytokines, and plasma proteins on IA, UIA, and SAH. These findings may contribute to a better understanding of the pathogenesis and potential therapeutic targets for these cerebrovascular diseases.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9764442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141994268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue and Sleepiness in Multiple Sclerosis and Their Response to Short-Term Treatment With Modafinil","authors":"Ann-Katrine Roswalld Thomsen,&nbsp;Marit Otto,&nbsp;Thor Petersen,&nbsp;Kristina Bacher Svendsen","doi":"10.1155/2024/2269483","DOIUrl":"10.1155/2024/2269483","url":null,"abstract":"<p><b>Background:</b> Patients with multiple sclerosis (pwMS) often experience significant fatigue. Simultaneously, previous studies show that pwMS frequently suffer from sleepiness and sleep problems. We aimed to contribute to the understanding of correlations between sleep and sleepiness/fatigue in pwMS to better identify responders to the wake-inducing drug, modafinil.</p><p><b>Methods:</b> This open-label, two-centre study included 26 pwMS suffering from daytime tiredness. Sleepiness, fatigue, and sleep were evaluated by questionnaires (Epworth Sleepiness Scale [ESS], Modified Fatigue Impact Scale [MFIS]/Multidimensional Fatigue Inventory [MFI-20], and Pittsburgh), daily sleep diary, and a wrist-worn actigraph before and after 3-week modafinil treatment.</p><p><b>Results:</b> One-third of the pwMS fulfilled the criteria of excessive daytime sleepiness (EDS, defined as ESS ≥ 10). Eighty-two percent (MFIS) of the patients were fatigued, and a high proportion (96%) of the pwMS were poor sleepers. Sleepiness (ESS) was inverse correlated to the subjective sleep quality. Actigraph data did not relate to subjective sleep, but total sleep time (TST) and higher sleep efficacy (SE) estimated by actigraph were positively correlated to the degree of fatigue. Modafinil had a positive effect on EDS.</p><p><b>Discussion:</b> In the present study, we found that the tired multiple sclerosis (MS) patient may suffer from both EDS and fatigue. We found an inverse correlation between EDS and subjective sleep quality. On the contrary, fatigue was positively correlated with longer TST and higher SE, estimated by actigraph. Sleepiness and fatigue did not correlate, and thus, it is highly relevant to distinguish these two symptoms. Modafinil only showed an effect on fatigue when the patient also suffered from EDS, which could suggest that ESS is a possible screening tool for responders to modafinil treatment.</p><p><b>Conclusion:</b> Sleepiness and fatigue do not seem to correlate in pwMS, and we recommend screening tools for sleepiness as well as sleep quality before initiating modafinil treatment to identify potential responders to the treatment.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2269483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141777133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life After Endovascular Thrombectomy for Acute Ischemic Stroke in Northern Finland","authors":"Ulla Junttola,&nbsp;Janne Liisanantti,&nbsp;Juha-Matti Isokangas,&nbsp;Timo Kaakinen,&nbsp;Merja Vakkala,&nbsp;Sanna Lahtinen","doi":"10.1155/2024/6684746","DOIUrl":"https://doi.org/10.1155/2024/6684746","url":null,"abstract":"<p><b>Objectives:</b> Endovascular thrombectomy has demonstrated a major therapeutic improvement in the treatment of acute ischemic stroke. The benefit of endovascular thrombectomy is commonly reported by determining the functional outcome using the modified Rankin Scale (mRS). There is a lack of knowledge concerning the quality of life (QoL) and factors impacting the QoL after endovascular thrombectomy. The aim of this study was to assess the QoL of stroke survivors who underwent endovascular thrombectomy and to determine the variables associated with QoL.</p><p><b>Methods:</b> Prospective single-center analysis of 98 patients who underwent endovascular thrombectomy between 2015 and 2019. QoL was assessed by using the Rand 36-Item Health Survey (RAND-36), Beck’s Depression Inventory (BDI), Stroke Impact Scale-16 (SIS-16), and Alcohol Use Disorders Identification Test (AUDIT) questionnaires.</p><p><b>Results:</b> Of the 98 patients, 53 (54.1%) reported poor QoL. According to the logistic regression analysis, the National Institutes of Health Stroke Scale (NIHSS) score &gt; 6 on the first postprocedural day, right hemispheric infarction, and depression were independently associated with poor QoL. Depression was reported by 40.8% of all the respondents. QoL scores of the patients treated with endovascular thrombectomy were impaired in physical functioning, physical and emotional role functioning, social functioning, and general health compared to the age-adjusted values of the Finnish general population.</p><p><b>Conclusion:</b> Endovascular thrombectomy (EVT)-treated stroke survivors experience disability in multiple levels. More than half of the patients report poor QoL. Neurological disability, functional dependence, depression, and comorbidities are associated with poor QoL. Social capability is impaired and the difficulties are more distinct among individuals with age above 65 years.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6684746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Inflammatory Markers in COVID-19-Related Ischemic Stroke: A Multicenter Retrospective Analysis","authors":"Yudi Li,&nbsp;Li Ling,&nbsp;Jie Li,&nbsp;Xiongjun He,&nbsp;Kaifeng Li,&nbsp;Yifan Wang,&nbsp;Fangming Li,&nbsp;Rucheng Huang,&nbsp;Li Yang,&nbsp;Yuxuan Ye,&nbsp;Yajie Liu","doi":"10.1155/2024/9022806","DOIUrl":"https://doi.org/10.1155/2024/9022806","url":null,"abstract":"<div>\u0000 <p>The novel coronavirus disease 2019 (COVID-19) causes severe respiratory illness and is involved in ischemic stroke. Aimed to investigate the inflammatory markers and possible prognosis of COVID-19-related ischemic stroke in a special outbreak period after lifting of COVID-19 control measures in China, we conducted a multicenter retrospective analysis in southern China at three centers in Shenzhen. We included patients diagnosed with acute ischemic stroke or transient ischemic attack after infection with COVID-19 as the COVID-19-related ischemic stroke group and those only diagnosed with acute ischemic stroke or transient ischemic attack as the control group. In this study, the proportion of female patients, admission heart rate, and comorbid coronary heart disease and the proportion of cryptogenic stroke were higher, while the history of prior stroke was lower in the COVID-19-related ischemic stroke group. The COVID-19-related ischemic stroke group also exhibited elevated levels of monocytes, fibrinogen, alanine aminotransferase, direct bilirubin, monocyte-to-lymphocyte ratio (MLR), and fibrinogen-to-albumin ratio (FAR) but decreased levels of lymphocytes, albumin, and high-density lipoprotein. However, there were no statistically significant differences in the modified Rankin scale (mRS), National Institutes of Health Stroke Scale (NIHSS), and mortality rate between the two groups at discharge. Our study is the first to show the alteration in inflammatory markers but no difference in discharge prognosis between the non-COVID-19 and the COVID-19-related ischemic stroke patients, during China’s COVID-19 relaxation period.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9022806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141439725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epileptic Network Surgery: From Network Basis to Clinical Practice","authors":"Di Wang,&nbsp;Huaqiang Zhang,&nbsp;Xiaotong Fan,&nbsp;Yanfeng Yang,&nbsp;Liankun Ren,&nbsp;Yongzhi Shan,&nbsp;Penghu Wei,&nbsp;Guoguang Zhao","doi":"10.1155/2024/1735404","DOIUrl":"https://doi.org/10.1155/2024/1735404","url":null,"abstract":"<div>\u0000 <p>Epilepsy is a common chronic neurologic disorder, with about 30%-40% of patients suffering from recurrent seizures despite receiving enough antiseizure medication. Growing evidence of extensive structural and functional research has revealed that epilepsy is a network disorder, and the network investigation is crucial in the presurgical evaluation. This narrative review is aimed at providing an overview of the conceptual development of epileptic surgery, the epileptic network formation, and the network-oriented strategy in clinical practice. We searched the PubMed database before October 2022 with no language or regional restrictions for studies of network exploration in epilepsy patients. The study eligibility criteria were original connectivity or network research studies using neuroimaging or neurophysiological approaches, focusing on seizure localization, neuropsychological evaluation, neuromodulation, or surgical prognosis. The initial search revealed 2046 studies. The selection process presented 746 papers that meet the inclusion criteria. The results indicated that epilepsy was characterized by the alternation of brain networks, which account for the clinical, electrographic, and neurocognitive phenomena related to human seizures and changes across different disease stages. Hubs have garnered significant attention due to their extensive connections, which make them prone to facilitating the spread of seizures to various brain regions. Unlike the seizure onset zone, the removal of the majority of these ictogenic nodes demonstrated a significant correlation with positive outcomes. Therefore, performing a network analysis during the epilepsy presurgical evaluation seems essential and will influence surgical decisions. It is hoped that studying the network of epilepsy will enhance our ability to determine the most appropriate surgical strategy for patients with epilepsy, thus contributing to success in terms of effective seizure control with maximal sparing or even improvement of brain functioning.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1735404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Quality of Life in Patients with Intracanalicular Vestibular Schwannomas after Gamma Knife Surgery Treatment: A Follow-Up Study","authors":"Mirosław Ząbek,&nbsp;Grzegorz Turek,&nbsp;Katarzyna Bieńkowska,&nbsp;Andrzej Kokoszka,&nbsp;Sebastian Dzierzęcki,&nbsp;Barbara Kostecka","doi":"10.1155/2024/5598225","DOIUrl":"https://doi.org/10.1155/2024/5598225","url":null,"abstract":"<div>\u0000 <p><i>Introduction</i>. Our previous research showed that the gamma knife surgery (GKS) is a highly effective treatment for intracanalicular vestibular schwannomas (IVS). In the current study, we aimed to evaluate long-term quality of life (QoL) as a follow-up to the assessment of baseline clinical and demographic parameters in the original study. Moreover, QoL outcomes were compared with norms for the general population and for patients who underwent different ear, nose, and throat (ENT) procedures. <i>Materials and Methods</i>. The follow-up study included 92 patients (59 women and 33 men; mean age, 61.71 ± 12.55 years; range: 32-85 years) with unilateral IVS who underwent GKS. Patients completed the <i>Assessment of Quality of Life</i>, Penn Acoustic Neuroma Quality-of-Life, Glasgow Benefit Inventory, and WHO-5 Well-being Index questionnaires as well as a demographic survey. Neurosurgical parameters were assessed using the Koos and House-Brackmann scales and the results of audiological examinations. <i>Results and Conclusions</i>. QoL scores were within or above the norm in 38% of patients. There were significant differences in terms of comorbidities and emotional well-being between patients with QoL scores within or above the norm and patients with QoL scores below the norm. Comorbidities were more common in patients with QoL scores below the norm, and they influenced reported QoL (<i>p</i> = 0.009). Patients with QoL scores within or above the norm reported better emotional well-being than those with QoL scores below the norm. Long-term QoL outcomes were satisfactory, consistent with the results of the original study. Although GKS is a complex procedure, patients reported higher QoL than those using hearing aids and the same QoL as those after ENT surgery or reassurance. However, they reported a slightly lower QoL than patients taking ENT medications. GKS appears to be a promising treatment option for patients with IVS.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5598225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141425115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intercultural Translation and Application of the German Version of King’s Parkinson’s Disease Pain Questionnaire in Fluctuating Parkinson’s Disease","authors":"Matthias Löhle,&nbsp;Wolfgang H. Jost,&nbsp;Alexander Bremer,&nbsp;Florin Gandor,&nbsp;Alexandra Rizos,&nbsp;Pablo Martinez-Martin,&nbsp;K. Ray Chaudhuri,&nbsp;Per Odin,&nbsp;Georg Ebersbach,&nbsp;Alexander Storch","doi":"10.1155/2024/6052552","DOIUrl":"https://doi.org/10.1155/2024/6052552","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Pain is common in Parkinson’s disease (PD) and impairs quality of life. The King’s PD pain questionnaire (KPPQ) is a standardized, reliable, and valid self-administered questionnaire for screening of pain in PD. We developed a linguistically validated German version of the KPPQ and applied it to a cohort with fluctuating PD. <i>Methods</i>. The interculturally adapted German translation was performed according to internationally accepted procedures in coordination with the authors of the original publication but without further psychometric validation. After final approval by all translators and original authors, the German version was then tested for feasibility and comprehension in 30 PD patients. After final adaption, the German KPPQ together with the German quantitative KPPS were applied to an independent cohort of fluctuating PD patients within the VALIDATE-PD study. <i>Results</i>. The use of the German version of the KPPQ in clinical practice or in the VALIDATE-PD study revealed no significant problems of understanding. Sufficient datasets were available from 47 patients with motor fluctuations (24 (51%) males, 23 (49%) females; median (interquartile range (IQR)) age: 65 (58-73) years; median (IQR) Hoehn and Yahr stage: 2.5 [2-3]). Total pain was reported by 43 (92%) of participants with a median number of 4 (IQR: 2-5) pain subtypes. We did not observe any associations of total pain frequency, neither with gender nor with other demographic or clinical parameters. <i>Conclusions</i>. The German version of the KPPQ is recommended as a questionnaire for assessing the frequency of pain and its subtypes in PD in clinical studies and/or routine care.</p>\u0000 </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6052552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}