Yousef Mokary, Saeed Vaheb, Mohammad Yazdan Panah, Alireza Afshari-Safavi, Elham Moases Ghaffary, Mahdi Barzegar, Ali Shirbacheh, Vahid Shaygannejad, Omid Mirmosayyeb
{"title":"男性复发性多发性硬化症患者唾液皮质醇水平与抑郁、焦虑和生活质量的关系：病例对照研究","authors":"Yousef Mokary, Saeed Vaheb, Mohammad Yazdan Panah, Alireza Afshari-Safavi, Elham Moases Ghaffary, Mahdi Barzegar, Ali Shirbacheh, Vahid Shaygannejad, Omid Mirmosayyeb","doi":"10.1155/2024/8728071","DOIUrl":null,"url":null,"abstract":"<p><b>Background:</b> Dysfunctions of the hypothalamic-pituitary-adrenal (HPA) axis can trigger multiple sclerosis (MS) symptoms. Mood disorders comorbid with MS are implicated in the HPA axis activation in most people with MS (pwMS). This study purposed to examine salivary cortisol (SC) levels and their association with mood disorders in pwMS.</p><p><b>Methods:</b> Forty-three men as pwMS and sixteen men as healthy controls (HC) were included in this study. pwMS and HC completed the Beck Depression Inventory (BDI), 36-Item Short Form Survey (SF-36), Fatigue Severity Scale (FSS), Depression Anxiety and Stress Scale, and Hospital Anxiety and Depression Scale questionnaires. SC levels were also measured in pwMS and HC. A linear regression model was used to analyze the relationship between the Expanded Disability Status Scale (EDSS) and mood disorders and SC levels. Pearson’s or Spearman’s tests examined the correlation between SC levels and mood disorders.</p><p><b>Results:</b> The SC level, anxiety, depression, fatigue, and stress were significantly higher in pwMS than in HC (<i>p</i> < 0.05). pwMS also showed significant correlations between SC levels and role physical (<i>r</i> = 0.3, <i>p</i> < 0.05) and emotional (<i>r</i> = 0.34, <i>p</i> < 0.05) in SF-36. Among SF-36 domains, only general health (<i>β</i> = −0.72, <i>p</i> < 0.05) and physical functioning (<i>β</i> = −1.61, <i>p</i> < 0.05) were negatively associated with disease duration. No correlation was found between SC levels and anxiety, depression, and fatigue (<i>p</i> > 0.05).</p><p><b>Conclusions:</b> The pwMS showed mild to moderate depression, anxiety, and fatigue. Only general health and physical functioning as aspects of quality of life were related to disease duration, while SC levels, mood disorders, and other quality-of-life domains were not associated with clinical characteristics. Also, this study failed to find a significant role for SC as a valuable marker in approaching mood disorders in pwMS.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2024 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8728071","citationCount":"0","resultStr":"{\"title\":\"The Association of Salivary Cortisol Levels With Depression, Anxiety, and Quality of Life in Male Relapsing-Remitting Multiple Sclerosis Patients: A Case-Control Study\",\"authors\":\"Yousef Mokary, Saeed Vaheb, Mohammad Yazdan Panah, Alireza Afshari-Safavi, Elham Moases Ghaffary, Mahdi Barzegar, Ali Shirbacheh, Vahid Shaygannejad, Omid Mirmosayyeb\",\"doi\":\"10.1155/2024/8728071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Background:</b> Dysfunctions of the hypothalamic-pituitary-adrenal (HPA) axis can trigger multiple sclerosis (MS) symptoms. Mood disorders comorbid with MS are implicated in the HPA axis activation in most people with MS (pwMS). This study purposed to examine salivary cortisol (SC) levels and their association with mood disorders in pwMS.</p><p><b>Methods:</b> Forty-three men as pwMS and sixteen men as healthy controls (HC) were included in this study. pwMS and HC completed the Beck Depression Inventory (BDI), 36-Item Short Form Survey (SF-36), Fatigue Severity Scale (FSS), Depression Anxiety and Stress Scale, and Hospital Anxiety and Depression Scale questionnaires. SC levels were also measured in pwMS and HC. A linear regression model was used to analyze the relationship between the Expanded Disability Status Scale (EDSS) and mood disorders and SC levels. Pearson’s or Spearman’s tests examined the correlation between SC levels and mood disorders.</p><p><b>Results:</b> The SC level, anxiety, depression, fatigue, and stress were significantly higher in pwMS than in HC (<i>p</i> < 0.05). pwMS also showed significant correlations between SC levels and role physical (<i>r</i> = 0.3, <i>p</i> < 0.05) and emotional (<i>r</i> = 0.34, <i>p</i> < 0.05) in SF-36. Among SF-36 domains, only general health (<i>β</i> = −0.72, <i>p</i> < 0.05) and physical functioning (<i>β</i> = −1.61, <i>p</i> < 0.05) were negatively associated with disease duration. No correlation was found between SC levels and anxiety, depression, and fatigue (<i>p</i> > 0.05).</p><p><b>Conclusions:</b> The pwMS showed mild to moderate depression, anxiety, and fatigue. Only general health and physical functioning as aspects of quality of life were related to disease duration, while SC levels, mood disorders, and other quality-of-life domains were not associated with clinical characteristics. Also, this study failed to find a significant role for SC as a valuable marker in approaching mood disorders in pwMS.</p>\",\"PeriodicalId\":6939,\"journal\":{\"name\":\"Acta Neurologica Scandinavica\",\"volume\":\"2024 1\",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8728071\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Neurologica Scandinavica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/2024/8728071\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neurologica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2024/8728071","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
The Association of Salivary Cortisol Levels With Depression, Anxiety, and Quality of Life in Male Relapsing-Remitting Multiple Sclerosis Patients: A Case-Control Study
Background: Dysfunctions of the hypothalamic-pituitary-adrenal (HPA) axis can trigger multiple sclerosis (MS) symptoms. Mood disorders comorbid with MS are implicated in the HPA axis activation in most people with MS (pwMS). This study purposed to examine salivary cortisol (SC) levels and their association with mood disorders in pwMS.
Methods: Forty-three men as pwMS and sixteen men as healthy controls (HC) were included in this study. pwMS and HC completed the Beck Depression Inventory (BDI), 36-Item Short Form Survey (SF-36), Fatigue Severity Scale (FSS), Depression Anxiety and Stress Scale, and Hospital Anxiety and Depression Scale questionnaires. SC levels were also measured in pwMS and HC. A linear regression model was used to analyze the relationship between the Expanded Disability Status Scale (EDSS) and mood disorders and SC levels. Pearson’s or Spearman’s tests examined the correlation between SC levels and mood disorders.
Results: The SC level, anxiety, depression, fatigue, and stress were significantly higher in pwMS than in HC (p < 0.05). pwMS also showed significant correlations between SC levels and role physical (r = 0.3, p < 0.05) and emotional (r = 0.34, p < 0.05) in SF-36. Among SF-36 domains, only general health (β = −0.72, p < 0.05) and physical functioning (β = −1.61, p < 0.05) were negatively associated with disease duration. No correlation was found between SC levels and anxiety, depression, and fatigue (p > 0.05).
Conclusions: The pwMS showed mild to moderate depression, anxiety, and fatigue. Only general health and physical functioning as aspects of quality of life were related to disease duration, while SC levels, mood disorders, and other quality-of-life domains were not associated with clinical characteristics. Also, this study failed to find a significant role for SC as a valuable marker in approaching mood disorders in pwMS.
期刊介绍：
Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.
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