Obesity Reviews最新文献

{"title":"The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.","authors":"Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen","doi":"10.1111/obr.13978","DOIUrl":"https://doi.org/10.1111/obr.13978","url":null,"abstract":"<p><p>Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors. These contributors affect regulatory mechanisms in the hypothalamus, hormonal signaling, and the gut-brain axis, all of which control energy intake, expenditure, and energy utilization in body tissues. In this context, particular attention is given to the role of genetic factors, which have a major impact on an individual's susceptibility to disease and support the development of personalized preventive and therapeutic approaches. Modern obesity treatment goes beyond weight reduction and focuses on optimizing body composition by reducing fat mass and increasing lean mass. This review includes a detailed overview of the mechanisms and clinical effects of current pharmacological approaches to obesity treatment, alongside other established strategies such as lifestyle modifications and bariatric surgery. It specifically discusses lipase inhibitors, opioid antagonists, sympathomimetics, and GLP-1 receptor agonists. Looking ahead, emerging therapies-such as microbiota modulation, dual and triple drug combinations, PYY agonists, and monoclonal antibodies-are expected to play a crucial role in the management of obesity. Furthermore, this review explores the potential of CRISPR-based technology for monogenic obesity, opening new avenues for targeted obesity treatments and identifying promising research directions. In the time to come, personalized medicine might have a fundamental place in the management of obesity, providing tailored and more effective therapeutic approaches that prioritize the long-term improvement of body composition and health outcomes in patients.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13978"},"PeriodicalIF":8.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re \"Cryolipolysis and Associated Health Outcomes, Adverse Events, and Satisfaction: A Systematic Review and Meta-Analysis\" Ravindran et al.","authors":"Nick Finer","doi":"10.1111/obr.70000","DOIUrl":"https://doi.org/10.1111/obr.70000","url":null,"abstract":"","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70000"},"PeriodicalIF":8.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpregnancy Weight Gain and Risks of Perinatal Death: A Systematic Review and Meta-Analysis.","authors":"Yu Tang, Nabil Islam, Rong Luo, Shi Wu Wen, Desheng Zhai, Ying Zhao, Laura M Gaudet, Yanfang Guo, Xiaoping Lei","doi":"10.1111/obr.13981","DOIUrl":"https://doi.org/10.1111/obr.13981","url":null,"abstract":"<p><p>The link between interpregnancy weight gain (IPWG) and perinatal death remains unclear. This meta-analysis examines the impact of interpregnancy body mass index (BMI) increase on perinatal mortality. A comprehensive search was conducted in July 2024 across MEDLINE, Embase, Cochrane Library, and Web of Science. Observational studies quantitatively reporting IPWG and associated perinatal mortality outcomes were included. IPWG was defined as a weight gain of ≥ 2 BMI units or moving to a higher BMI category between consecutive pregnancies. The risk of bias was assessed using the ROBINS-I tool. Random effects meta-analyses were performed to generate pooled adjusted odds ratios (aORs) and 95% confidence intervals (CIs). The analysis included 10 studies (3,072,698 pregnancies). The primary outcome was perinatal death (deaths occurring at ≥ 20 weeks of gestation up to 28 days postpartum). Secondary outcomes were stillbirth (intrauterine fetal death at ≥ 20 weeks) and neonatal death (deaths among live-born infants within 28 days of life). IPWG significantly increases the risk of perinatal death (aOR, 1.49; 95% CI, 1.32-1.69), stillbirth (aOR, 1.46; 95% CI, 1.23-1.72), and neonatal death (aOR, 1.39; 95% CI, 1.19-1.61), compared to stable interpregnancy weight. These findings suggest that IPWG may increase the risk of perinatal death, highlighting the importance of weight management counseling during the interpregnancy period.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13981"},"PeriodicalIF":8.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is My Risk? A Mixed-Methods Systematic Review of Risk Perception for Cardiometabolic Pregnancy Complications and Future Cardiometabolic Disease Development.","authors":"Elaine K Osei-Safo, Jennifer McIntosh, Shakira Onwuka, Sophia Torkel, Margaret McGowan, Kristie Cocotis, Caitlyn Angel, Sanjay Varatharaj, Helena Teede, Angela Melder, Sarah Lang, Lisa J Moran","doi":"10.1111/obr.13967","DOIUrl":"https://doi.org/10.1111/obr.13967","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiometabolic pregnancy complications increase future cardiometabolic disease risk. Accurate risk perception plays a central role in adopting risk-reducing lifestyle and health-related behaviors, such as healthy eating, physical activity, and weight management. This review aimed to explore high-risk pregnant and postpartum women's perception of their risk of developing cardiometabolic pregnancy complications or future cardiometabolic disease.</p><p><strong>Methods: </strong>Systematic search identified quantitative and qualitative data exploring risk perception in women (pregnant/postpartum) at risk of or diagnosed with gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), intrauterine growth restriction (IUGR), and preterm birth (PTB). A convergent integrated mixed-methods synthesis was undertaken, with findings interpreted using the health belief and capability, opportunity, and motivation for behavior change models.</p><p><strong>Results: </strong>Overall, 84 studies were included, with the majority in GDM (77.4%) and HDP (23.8%), with limited research in PTB (8.3%) and IUGR (6.0%). Women had low-moderate knowledge of pregnancy complications as risk factors for future cardiometabolic disease and low-moderate perceived susceptibility to potential pregnancy complications and future cardiometabolic disease. Self-perceived barriers, facilitators, cues to action, self-efficacy, and self-optimism impacted engagement with lifestyle and screening measures. The highest risk perception for future type 2 diabetes or cardiovascular disease was among women who had previously experienced GDM or HDP, respectively.</p><p><strong>Conclusion: </strong>Designing interventions to optimize women's risk perception will support informed decision-making and empower women to make lifestyle changes to reduce future cardiometabolic risk.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13967"},"PeriodicalIF":8.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi Consensus Among French Obesity Experts on Clinical Recommendations for Drug Prescription in Patients With Severe Obesity.","authors":"Sarah Berdot, Germain Perrin, Emmanuel Disse, Armelle Arnoux, Eric Bertin, Anne-Laure Borel, Marie-Claude Brindisi, Arnaud De Luca, Edouard-Jules Laforgue, Jean-Daniel Lalau, Yann Matussiere, Emilie Montastier, Agnès Sallé, Bérénice Segrestin, Valentine Suteau, Sebastien Czernichow, Brigitte Sabatier","doi":"10.1111/obr.13977","DOIUrl":"https://doi.org/10.1111/obr.13977","url":null,"abstract":"<p><strong>Introduction: </strong>Although the physiologic alterations seen in obesity often affect the pharmacokinetics and pharmacodynamics of drugs, most clinical trials do not consider these aspects specifically for this population. To date, there is no list of potentially inappropriate medications for patients living with obesity. The aim of this study was to use the Delphi method to identify useful recommendations for the prescription of some specific drug classes in patients living with severe obesity.</p><p><strong>Methods: </strong>We identified five therapeutic groups of drugs using data from the HEGP Clinical Data Warehouse. We conducted a literature review and sought the opinions of local experts to produce potential recommendations. We selected volunteer medical experts from the French network FORCE and set up a two-round Delphi method, concluded by a synthesis meeting, to establish a list of recommendations. In each round, the experts were asked to rate the potential recommendations.</p><p><strong>Results: </strong>Forty-three proposed recommendations were evaluated in the first round. The experts approved four recommendations with a strong consensus and 16 with a relative consensus. In the second round, they approved six recommendations with a strong consensus and 13 with a relative consensus.</p><p><strong>Conclusion: </strong>This is the first study to use the Delphi method to produce a summary of consensus recommendations for several drug classes in patients living with severe obesity. It provides an expert-based consensus on the use of the five most commonly prescribed therapeutic drug classes and develops a list of recommendations for drug prescription in patients living with severe obesity.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13977"},"PeriodicalIF":8.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Cultural Competence and Cultural Responsiveness of Healthcare Services That Promote Early Prevention of Childhood Obesity: A Scoping Review.","authors":"Zoe Chen, Sarah El Wazni, Erin Kerr, Huilan Xu, Li Ming Wen, Sarah Taki","doi":"10.1111/obr.13979","DOIUrl":"https://doi.org/10.1111/obr.13979","url":null,"abstract":"<p><strong>Background: </strong>Early childhood is a critical period to prevent future poor health outcomes. The modification of health behaviors in the first 2000 days of life is particularly crucial. Yet, obesity is increasingly prevalent in children from culturally and linguistically diverse (CALD) backgrounds, demonstrating a need to provide culturally-tailored care to this population.</p><p><strong>Aims: </strong>To understand the extent of literature that explores cultural competence and responsiveness of preventive healthcare services delivered to culturally and linguistically diverse families (CALD) in the first 2000 days and to identify gaps in the literature and key characteristics and outcomes in these studies that are associated with culturally competent and responsive healthcare.</p><p><strong>Methods: </strong>A search strategy was developed, and five databases were searched. Title and abstract screening, full-text screening, data extraction, and quality appraisal were performed by two or more independent reviewers.</p><p><strong>Results: </strong>A total of 28 included studies identified bilingual facilitators, language-modified materials, and educational resources as key characteristics associated with culturally competent care. Improved breastfeeding practices and increased engagement with healthcare services were identified as key outcomes. Studies involving healthcare cultural competence training were associated with significant changes in outcomes.</p><p><strong>Conclusion: </strong>Many characteristics and health outcomes associated with culturally competent and responsive care were identified in this review. However, preventive health services delivered to CALD families are still an area of research and practice that is lacking cultural competence. A multidisciplinary and community-centered approach is needed to improve health services delivered to CALD families and address persistent barriers to healthcare.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13979"},"PeriodicalIF":8.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Effects of Exercise Timing on Metabolic Health\".","authors":"","doi":"10.1111/obr.13976","DOIUrl":"https://doi.org/10.1111/obr.13976","url":null,"abstract":"","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13976"},"PeriodicalIF":8.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Do Trauma- and Violence-Informed Care Approaches Underpin Bariatric Surgery Interventions for Type 2 Diabetes Mellitus Remission? A Scoping Review.","authors":"Michelle Greenway, Michelle Domjancic, Yixuan Claire Liu, Alegria Benzaquen, Megan Racey, Susan M Jack, Diana Sherifali, Carly Whitmore","doi":"10.1111/obr.13980","DOIUrl":"https://doi.org/10.1111/obr.13980","url":null,"abstract":"<p><p>For individuals living with obesity, bariatric surgery is an effective intervention for type 2 diabetes mellitus (T2DM) remission. Given the established relationships between trauma and obesity, and obesity and T2DM, there is a need to examine bariatric surgical practices from a trauma- and violence-informed care (TVIC) perspective. The purpose of this scoping review was to explore and describe the extent to which the four TVIC principles-(1) understand trauma, violence, and its impact; (2) create emotionally and physically safe environments; (3) foster opportunities for choice, collaboration, and connection; and (4) use a strengths-based and capacity-building approach-have been integrated into bariatric surgery processes for T2DM remission. Following the PRISMA-ScR framework, we searched MEDLINE and EMBASE from inception to January 2024. Eligible studies included adults ≥ 18 years with T2DM undergoing bariatric surgery and reporting remission outcomes. Data were summarized narratively and charted using the TIDieR checklist. Nineteen studies were included, described in 30 publications. Despite established associations between trauma, obesity, and chronic illness, none of the included studies collected demographic data on participants' history of trauma or violence. Among included studies, mental health exclusions were common, potentially limiting access for individuals with trauma-related mental health challenges. Our findings highlight the absence of reporting TVIC principles in bariatric surgery for T2DM remission, raising concerns about emotional safety, risks for retraumatization, and long-term outcomes. Integrating the principles of TVIC throughout bariatric surgical care is essential to promote emotionally safe and inclusive care to enhance postoperative success and sustained health outcomes.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13980"},"PeriodicalIF":8.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Loss-Associated Remodeling of Adipose Tissue Immunometabolism.","authors":"Paulo José Basso, Alejandro Schcolnik-Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente-Casares, Sue Tsai","doi":"10.1111/obr.13975","DOIUrl":"https://doi.org/10.1111/obr.13975","url":null,"abstract":"<p><p>Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low-grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity-related health conditions. However, this field of investigation, also known as immunometabolism, requires more in-depth study to fully understand the impact of weight loss treatments on the metabolism and function of immune cells. Despite indications that weight loss can alleviate certain metabolic dysfunctions associated with obesity, the extent to which immunometabolic parameters return to baseline posttherapy remains largely unexplored. Therefore, this review intends to re-examine critical aspects of obesity pathophysiology and highlight recent advancements in literature regarding the effects of weight loss interventions on the metabolism and function of immune cells. Addressing this field is crucial for optimizing obesity management strategies and gaining insights into long-term metabolic health outcomes.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13975"},"PeriodicalIF":8.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Partnerships With Commercial Actors to Improve Food Environments: A Systematic Review.","authors":"Laurence Blanchard, Gemma Bridge, Julia Bidonde, Matt Egan, Harry Rutter, Mark Petticrew, Patricia J Lucas, Monique Potvin Kent, Claire Bennet, Stephanie Ray, Cherry Law, Cécile Knai","doi":"10.1111/obr.13952","DOIUrl":"https://doi.org/10.1111/obr.13952","url":null,"abstract":"<p><p>Partnerships with commercial actors have been proposed as a policy approach to create healthier food environments. We conducted a systematic review to assess their effectiveness for improving food environments and population health at state, national, or international levels. We searched in 14 databases and two websites for real-world evaluations published between 2010 and 2020. Study quality was appraised using a modified Newcastle-Ottawa Scale. Data were synthesized narratively by outcome (human, food environment, policy content, and implementation progress), considering their effect direction. Seventeen studies reporting on seven PPPs in four countries were included. Most studies (n = 14) involved food reformulation, especially salt reduction. Three focused on specific settings (the eating out-of-home sector, schools, and convenience stores). There was mixed evidence that partnerships make people buy fewer calories or more school meals (n = 3 studies) or reduce product sodium content (n = 6). Some positive effects were described in one uncontrolled study each for decreasing trans-fatty acid intake and for making healthier options more available in school cafeterias, but these studies had important limitations. Five document analyses highlighted shortcomings in the partnerships, including their limited scope, failure to add value to ongoing actions, varying participation levels, and lack of implementation, monitoring, and reporting. Alternative policy approaches should be considered. This systematic review is registered on PROSPERO as CRD42020170963.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13952"},"PeriodicalIF":8.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}