Obesity Reviews最新文献

{"title":"The prognostic role of food addiction for weight loss treatment outcomes in individuals with overweight and obesity: A systematic review and meta-analysis","authors":"Georg Halbeisen,&nbsp;Marie Pahlenkemper,&nbsp;Luisa Sabel,&nbsp;Candice Richardson,&nbsp;Zaida Agüera,&nbsp;Fernando Fernandez-Aranda,&nbsp;Georgios Paslakis","doi":"10.1111/obr.13851","DOIUrl":"10.1111/obr.13851","url":null,"abstract":"<p>Food addiction (FA) could be a potential prognostic factor of weight loss intervention outcomes. This systematic review with meta-analysis aimed to (1) estimate this prognostic effect of FA diagnosis and symptom count in individuals with overweight or obesity and (2) explore potential sources of heterogeneity based on properties of the weight loss intervention, study, and sample (e.g., age, gender, ethnicity). We searched PubMed, PsycINFO, and Web of Science for studies reporting on associations between pre-intervention FA (assessed with the Yale Food Addiction Scale) and weight outcomes after weight loss intervention in individuals with overweight or obesity without a medically diagnosed eating disorder. Twenty-five studies met inclusion criteria, including 4904 individuals (71% women, <i>M</i>_age = 41 years, BMI = 40.82 kg/m²), <i>k</i> = 18 correlations of weight loss with FA symptom count, and <i>k</i> = 21 mean differences between FA diagnosis groups. Pooled estimates of random-effects meta-analyses found limited support for a detrimental effect of FA symptom count and diagnosis on weight loss intervention outcomes. Negative associations with FA increased for behavioral weight loss interventions and among more ethnically diverse samples. More research on the interaction of FA with pre-existing mental health problems and environmental factors is needed.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causality of visceral adipose tissue on chronic kidney disease and renal function measure indicators, and mediation role of hypertension: Mendelian randomization study","authors":"Teng-Yu Gao,&nbsp;Jun-Chi Wang,&nbsp;Qi-Jian Zhao,&nbsp;Xiang-Ning Zhou,&nbsp;Yu-Ting Jiang,&nbsp;Lian Ren,&nbsp;Chao Zhang","doi":"10.1111/obr.13845","DOIUrl":"10.1111/obr.13845","url":null,"abstract":"<p>Although chronic kidney disease (CKD) is associated with obesity, few studies have used visceral adipose tissue (VAT) as an indicator to investigate its causal effect on CKD. Therefore, Mendelian randomization (MR) was employed to study the causal effects of VAT on CKD and its potential mediation by hypertension. Genome-wide association study (GWAS) statistics on VAT exposure were obtained from the UK Biobank, while GWAS datasets of CKD outcomes were obtained from CKDGen and FinnGen (validation study). Furthermore, VAT was considered the exposure, with the estimated glomerular filtration rate based on creatinine (eGFR (crea)), estimated glomerular filtration rate based on cystatin C (eGFR(cys)), and blood urea nitrogen (BUN) employed to assess the causal effect of VAT on kidney test indicators. Lastly, a two-step MR method was used to study the mediating role of hypertension in the pathogenesis of VAT among patients with CKD. VAT exhibited a positive causal association with CKD, irrespective of whether the GWAS datasets from CKDGen (odds ratio [OR] = 1.18, 95% CI: 1.08 to 1.29, P = 1.433140e−04) or FinnGen (1.47, 1.30 to 1.67, <i>p</i> = 2.500000e−09). VAT was not causally associated with eGFR (crea) (1.00, 0.99 to 1.00, <i>p</i> = 0.53), was negatively associated with eGFR (cys) (0.95, 0.93 to 0.97, P = 5.070000e−10), and was positively associated with BUN (1.02,1.01 to 1.02, P = 7.824860e−04). The mediating effect of VAT on CKD via hypertension was 45.8% (95% CI: 26.4 65.1). VAT has a positive causal effect on CKD, with hypertension playing a significant role. However, the effects of VAT on renal function indicators require further investigation.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight/height2: Mathematical overview of the world's most widely used adiposity index","authors":"Steven B. Heymsfield,&nbsp;John D. Sorkin,&nbsp;Diana M. Thomas,&nbsp;Shengping Yang,&nbsp;Moonseong Heo,&nbsp;Cassidy McCarthy,&nbsp;Jasmine Brown,&nbsp;Angelo Pietrobelli","doi":"10.1111/obr.13842","DOIUrl":"10.1111/obr.13842","url":null,"abstract":"<p>A footnote in Adolphe Quetelet's classic 1835 Treatise on Man described his algebraic analysis of how body weight (\u0000<span></span><math>\u0000 <mi>W</mi></math>) varies with height (\u0000<span></span><math>\u0000 <mi>H</mi></math>) in adult males and females. Using data on 12 short and 12 tall subjects of each sex, Quetelet established the rule that \u0000<span></span><math>\u0000 <mi>W</mi></math> is approximately proportional (\u0000<span></span><math>\u0000 <mo>∝</mo></math>) to <i>H</i>² in adults; that is, \u0000<span></span><math>\u0000 <mi>W</mi>\u0000 <mo>∝</mo>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math> when \u0000<span></span><math>\u0000 <mi>W</mi>\u0000 <mo>≈</mo>\u0000 <mi>α</mi>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math> for some constant \u0000<span></span><math>\u0000 <mi>α</mi></math>. Quetelet's Rule (\u0000<span></span><math>\u0000 <mi>W</mi>\u0000 <mo>∝</mo>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math>), transformed and renamed in the twentieth century to body mass index (\u0000<span></span><math>\u0000 <mi>BMI</mi>\u0000 <mo>=</mo>\u0000 <mi>W</mi>\u0000 <mo>/</mo>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math>), is now a globally applied phenotypic descriptor of adiposity at the individual and population level. The journey from footnote to ubiquitous adiposity measure traveled through hundreds of scientific reports and many more lay publications. The recent introduction of highly effective pharmacologic weight loss treatments has heightened scrutiny of BMI's origins and appropriateness as a gateway marker for diagnosing and monitoring people with obesity. This contemporary context prompted the current report that delves into the biological and mathematical paradigms that underlie the simple index \u0000<span></span><math>\u0000 <mi>BMI</mi>\u0000 <mo>=</mo>\u0000 <mi>W</mi>\u0000 <mo>/</mo>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math>. Students and practitioners can improve or gain new insights into their understanding of BMI's historical origins and quantitative underpinning from the provided overview, facilitating informed use of BMI and related indices in research and clinical settings.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on drug repurposing applicable to obesity","authors":"Feng Chen,&nbsp;Kai Jing,&nbsp;Zhen Zhang,&nbsp;Xia Liu","doi":"10.1111/obr.13848","DOIUrl":"10.1111/obr.13848","url":null,"abstract":"<div>\u0000 \u0000 <p>Obesity is a major public health concern and burden on individuals and healthcare systems. Due to the challenges and limitations of lifestyle adjustments, it is advisable to consider pharmacological treatment for people affected by obesity. However, the side effects and limited efficacy of available drugs make the obesity drug market far from sufficient. Drug repurposing involves identifying new applications for existing drugs and offers some advantages over traditional drug development approaches including lower costs and shorter development timelines. This review aims to provide an overview of drug repurposing for anti-obesity medications, including the rationale for repurposing, the challenges and approaches, and the potential drugs that are being investigated for repurposing. Through advanced computational techniques, researchers can unlock the potential of repurposed drugs to tackle the global obesity epidemic. Further research, clinical trials, and collaborative efforts are essential to fully explore and leverage the potential of drug repurposing in the fight against obesity.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Role of telemedicine in the management of obesity: State of the art review”","authors":"","doi":"10.1111/obr.13846","DOIUrl":"10.1111/obr.13846","url":null,"abstract":"<p>\u0000 <span>Shariq, K.</span>, <span>Siddiqi, TJ</span>, <span>Spall, H</span>, et al. <span>Role of telemedicine in the management of obesity: state-of-the-art review</span>. <i>Obes Rev</i>. <span>2024</span>; <span>25</span>(<span>6</span>)e13734. doi:10.1111/obr.13734</p><p>The corresponding author of this article should be Kainat Shariq. Details of the new corresponding author are mentioned below.</p><p>Kainat Shariq, MBBS, Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan. Email: <span>[email protected]</span></p><p>We apologize for this error.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of interventions aimed at reducing explicit and implicit weight bias in healthcare students: A systematic review and meta-analysis","authors":"Ravisha S. Jayawickrama,&nbsp;Briony Hill,&nbsp;Moira O'Connor,&nbsp;Stuart W. Flint,&nbsp;Erik Hemmingsson,&nbsp;Lucy R. Ellis,&nbsp;Yaxing Du,&nbsp;Blake J. Lawrence","doi":"10.1111/obr.13847","DOIUrl":"10.1111/obr.13847","url":null,"abstract":"<p>We conducted a systematic review and meta-analysis to determine the efficacy of interventions aimed at reducing weight bias in healthcare students, and to explore factors that may impact intervention success. A systematic review and random-effects meta-analyses were conducted by including studies that examined the efficacy of weight bias reduction interventions for healthcare students. Of the 3463 journal articles and dissertations screened, 67 studies (within 64 records) met inclusion criteria, with 35 studies included in the meta-analyses (explicit = 35, implicit [and explicit] = 10) and 32 studies included in the narrative synthesis (explicit = 34, implicit [and explicit] = 3). Weight bias interventions had a small but positive impact, <i>g</i> = −0.31 (95% CI = −0.43 to −0.19, <i>p</i> &lt; 0.001), in reducing students' <i>explicit</i> weight bias but there was no intervention effect on <i>implicit</i> weight bias, <i>g</i> = −0.12 (95% CI = −0.26 to 0.02, <i>p</i> = 0.105). There was considerable heterogeneity in the pooled effect for explicit bias (<i>I</i>^<i>2</i> = 74.28, <i>Q</i> = 132.21, <i>df</i> = 34, <i>p</i> &lt; 0.001). All subgroup comparisons were not significant (<i>p</i> &gt; 0.05) and were unable to explain the observed heterogeneity. Narrative synthesis supported meta-analytic findings. The small but significant reduction of explicit weight bias encourages the continued testing of interventions, irrespective of variation in individual intervention components. Contrarily, reductions in implicit weight bias may only be possible from a large societal shift in negative beliefs and attitudes held towards people living in larger bodies.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric surgeries and cardiac structure and function: Systematic review and network meta-analysis","authors":"Xiao-Qian Zhang,&nbsp;Ke-Ning Chen,&nbsp;Zu-Xuan Zhang,&nbsp;Nian-Rong Zhang,&nbsp;Fang-Jie-Yi Zheng,&nbsp;Biao Zhou,&nbsp;Hua Meng,&nbsp;Zhi-Xin Zhang,&nbsp;Wen-Quan Niu","doi":"10.1111/obr.13843","DOIUrl":"10.1111/obr.13843","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Obesity, a global health problem, is causally implicated in the development of cardiovascular disease. Bariatric surgeries are effective treatment options for obesity; however, the effectiveness of different bariatric surgeries on cardiac structure and function is not fully understood. We undertook a systematic review and network meta-analysis to comprehensively assess this effectiveness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Data source</h3>\u0000 \u0000 <p>PubMed, Web of Science, and EMBASE were searched from their inception until November 11, 2023. Studies that compared bariatric surgeries vis-à-vis non-surgical treatment, placebo, and other bariatric surgeries, as well as reported changes in left ventricular mass or its index (LVM or LVMI) or left ventricular ejection fraction (LVEF), were summarized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Total 19 studies (17 cohort studies and 2 randomized controlled trials) and 2012 adults were meta-analyzed. Patients receiving gastric bypass had appreciably lowered LVM (weighted mean difference [WMD]: −43.86 g, 95% confidence interval [CI] −61.09 to −26.63, <i>p</i> &lt; 0.01) and LVMI (standardized mean difference: −0.67, 95% CI −1.03 to −0.32, <i>p</i> &lt; 0.01) compared with other bariatric surgeries. No significant improvement in LVEF was noted across all surgeries. The drop in body mass index was most pronounced for biliopancreatic diversion with duodenal switch (WMD −16.33 kg/m², 95% CI −21.60 to −11.05, <i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings of this network meta-analysis indicated that gastric bypass proved best for the improvement in cardiac structure, and there was no obvious improvement in cardiac function for all bariatric surgeries. Further studies are required to better understand the differing effectiveness of bariatric surgeries on cardiac structure and function and the underlying molecular mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary calcium intake in relation to metabolic syndrome in adults: A systematic review and dose–response meta-analysis of epidemiological studies with GRADE assessment","authors":"Roxana Nematbakhsh,&nbsp;Parisa Rouhani,&nbsp;Parvane Saneei","doi":"10.1111/obr.13850","DOIUrl":"10.1111/obr.13850","url":null,"abstract":"<div>\u0000 \u0000 <p>Numerous studies have examined the relationship of calcium intake and metabolic syndrome (MetS) in adults in previous decades; but the results were inconsistent across different societies. This systematic review and dose–response meta-analysis assessed the relation between calcium consumption and MetS in adults. We did a systematic search of all articles published up to July 2023 in Scopus, PubMed/Medline, ISI Web of Science electronic databases, and Google Scholar. Observational studies investigated the association between dietary calcium (Ca) intake and MetS in adults were eligible to be included. For computing the estimates, a random effects model was applied. Combining 24 effect size from 17 investigations (15 cross-sectional and two cohort studies) with 74,720 participants and 18,200 cases showed that highest versus lowest level of dietary Ca intake was related to 23% significant decreased odds of MetS (OR = 0.77; 95% CI: 0.66, 0.89). Linear dose–response analysis of estimates from 12 investigations showed that each 100 mg/day increment in dietary Ca intake was associated with 3% marginally significant decreased odds in MetS (OR = 0.97; 95%CI: 0.93, 1.01). In nonlinear dose–response analysis of 12 studies with 67,896 participants, a significant association between dietary calcium intake and MetS was found (P_nonlinearity &lt;0.001); such that 500 mg/day dietary calcium intake was related to maximum decrease in odds of MetS. According to this meta-analysis, the likelihood of MetS was significantly lower in adults with higher level of dietary calcium intake. Further large-scale prospective cohort investigations are needed to obtain stronger and more accurate results.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics: Implication in cardiovascular research and diseases","authors":"Amir Ajoolabady,&nbsp;Domenico Pratico,&nbsp;Warwick B. Dunn,&nbsp;Gregory Y. H. Lip,&nbsp;Jun Ren","doi":"10.1111/obr.13825","DOIUrl":"10.1111/obr.13825","url":null,"abstract":"<div>\u0000 \u0000 <p>Cellular metabolism influences all aspects of cellular function and is crucial for overall organismal health. Metabolic disorders related to cardiovascular health can lead to cardiovascular diseases (CVDs). Moreover, associated comorbidities may also damage cardiovascular metabolism, exacerbating CVD and perpetuating a vicious cycle. Given the prominent role of metabolic alterations in CVD, metabolomics has emerged as an imperative technique enabling a comprehensive assessment of metabolites and metabolic architecture within the body. Metabolite profile and metabolic pathways help to deepen and broaden our understanding of complex genomic landscape and pathophysiology of CVD. Here in this review, we aim to overview the experimental and clinical applications of metabolomics in pathogenesis, diagnosis, prognosis, and management of various CVD plus future perspectives and limitations.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 12","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential pathways to the onset and development of eating disorders in people with overweight and obesity: A scoping review","authors":"Rabia Khalid,&nbsp;Natalie B. Lister,&nbsp;Susan J. Paxton,&nbsp;Sarah Maguire,&nbsp;Sol Libesman,&nbsp;Anna L. Seidler,&nbsp;Kelly Cooper,&nbsp;Fiona Quigley,&nbsp;Jacqlyn Yourell,&nbsp;Louise A. Baur,&nbsp;Hiba Jebeile","doi":"10.1111/obr.13840","DOIUrl":"10.1111/obr.13840","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To describe pathways to eating disorder (ED) development that have been evaluated in people with overweight and obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Four databases were searched to identify studies testing ED development models in adolescents (10–19 years) or adults (&gt;19 years) with overweight and obesity. Explanatory variables were thematically grouped into constructs to describe pathways to each ED outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 2226 studies screened, 46 (10 adolescent; 36 adult) were included. Study samples were predominantly female, ranging from 22 to 2236 participants and mean age 12.3 to 56.0 years. In total, 207 explanatory variables were grouped into 18 constructs to summarize 107 pathways that were identified. The most common ED outcome was binge eating (<i>n</i> = 24 studies), followed by global ED psychopathology (<i>n</i> = 10 studies). Across pathways to ED development, negative affect was the most proposed construct, followed by preoccupation with weight/shape and weight stigma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pathways to ED development in people with overweight and obesity are complex and may include more than 18 different explanatory factors of which negative affect, preoccupation with weight/shape, and weight stigma are the most common. More research on adolescents, males, and the spectrum of ED in diverse populations is required for early identification and intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}