Obesity Reviews最新文献_第10页

Is the uptake, engagement, and effectiveness of exclusively mobile interventions for the promotion of weight-related behaviors equal for all? A systematic review 对于促进体重相关行为的专门移动干预的吸收、参与和有效性是否对所有人都是平等的?系统回顾

IF 8.9 2区医学

Obesity Reviews Pub Date : 2023-01-09 DOI: 10.1111/obr.13542

Dorothy Szinay, Cynthia C. Forbes, Heide Busse, Ann DeSmet, Eline S. Smit, Laura M. K?nig

{"title":"Is the uptake, engagement, and effectiveness of exclusively mobile interventions for the promotion of weight-related behaviors equal for all? A systematic review","authors":"Dorothy Szinay, Cynthia C. Forbes, Heide Busse, Ann DeSmet, Eline S. Smit, Laura M. K?nig","doi":"10.1111/obr.13542","DOIUrl":"https://doi.org/10.1111/obr.13542","url":null,"abstract":"Mobile health interventions are promising behavior change tools. However, there is a concern that they may benefit some populations less than others and thus widen inequalities in health. This systematic review investigated differences in uptake of, engagement with, and effectiveness of mobile interventions for weight-related behaviors (i.e., diet, physical activity, and sedentary behavior) based on a range of inequality indicators including age, gender, race/ethnicity, and socioeconomic status. The protocol was registered on PROSPERO (CRD42020192473). Six databases (CINAHL, EMBASE, ProQuest, PsycINFO, Pubmed, and Web of Science) were searched from inception to July 2021. Publications were eligible for inclusion if they reported the results of an exclusively mobile intervention and examined outcomes by at least one inequality indicator. Sixteen publications reporting on 13 studies were included with most reporting on multiple behaviors and inequality indicators. Uptake was investigated in one study with no differences reported by the inequality indicators studied. Studies investigating engagement (n = 7) reported differences by age (n = 1), gender (n = 3), ethnicity (n = 2), and education (n = 2), while those investigating effectiveness (n = 9) reported differences by age (n = 3), gender (n = 5), education (n = 2), occupation (n = 1), and geographical location (n = 1). Given the limited number of studies and their inconsistent findings, evidence of the presence of a digital divide in mobile interventions targeting weight-related behaviors is inconclusive. Therefore, we recommend that inequality indicators are specifically addressed, analyzed, and reported when evaluating mobile interventions.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 3","pages":""},"PeriodicalIF":8.9,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5776701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Youth involvement in policy processes in public health, education, and social work: Protocol for a scoping review 青年参与公共卫生、教育和社会工作的政策进程:范围审查议定书

IF 8.9 2区医学

Obesity Reviews Pub Date : 2023-01-09 DOI: 10.1111/obr.13544

Arnfinn Helleve, Gerd Monika Flodgren, Laurence Blanchard, Anne-Siri Fismen, Harry Rutter, Jonas Rekdal Mathisen, Knut-Inge Klepp

引用次数: 0

Policy, system, and environmental interventions addressing obesity and diet-related outcomes in early childhood education settings: A systematic review 儿童早期教育环境中解决肥胖和饮食相关结果的政策、系统和环境干预:系统综述

IF 8.9 2区医学

Obesity Reviews Pub Date : 2023-01-05 DOI: 10.1111/obr.13547

Chelsea L. Kracht, Sarah Burkart, Emily W. Flanagan, Emily Melnick, Courtney Luecking, Cody Neshteruk

{"title":"Policy, system, and environmental interventions addressing obesity and diet-related outcomes in early childhood education settings: A systematic review","authors":"Chelsea L. Kracht, Sarah Burkart, Emily W. Flanagan, Emily Melnick, Courtney Luecking, Cody Neshteruk","doi":"10.1111/obr.13547","DOIUrl":"https://doi.org/10.1111/obr.13547","url":null,"abstract":"<div>\u0000 \u0000 Early childhood education (ECE) settings play an important role in child dietary intake and excess weight gain. Policy, systems, and environment (PSE) approaches have potential to reduce disparities in children at higher risk for obesity. The purpose of this review was to (1) characterize the inclusion of populations at higher risk for obesity in ECE interventions and (2) identify effective ECE interventions in these populations. Seven databases were searched for ECE interventions. Intervention characteristics and methodological quality were assessed in 35 articles representing 34 interventions. Interventions identified were mainly a combination of ECE and parent interventions (41%) or stand-alone ECE intervention (29%), with few multisector efforts (23%) or government regulations assessed (5%). Many included policy (70%) or social environment components (61%). For Aim 1, two thirds were conducted in primarily populations at higher risk for obesity (67%). Studies were rated as fair or good methodological quality. For Aim 2, 10 studies demonstrated effectiveness at improving diet or reducing obesity in populations at higher risk for obesity. Most included a longer intervention (i.e., >6 months), multiple PSE components, and formative work. Opportunities to incorporate more PSE components in ECE-based interventions and collaborate with parents and communities are warranted to improve child health.\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 4","pages":""},"PeriodicalIF":8.9,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13547","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5710700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparative effectiveness of glucagon-like peptide-1 receptor agonists for the management of obesity in adults without diabetes: A network meta-analysis of randomized clinical trials 胰高血糖素样肽-1受体激动剂治疗无糖尿病成人肥胖的比较疗效:随机临床试验的网络荟萃分析

IF 8.9 2区医学

Obesity Reviews Pub Date : 2022-12-29 DOI: 10.1111/obr.13543

Omar S. Alkhezi, Abdullah A. Alahmed, Osamah M. Alfayez, Osama A. Alzuman, Abdulaali R. Almutairi, Omar A. Almohammed

{"title":"Comparative effectiveness of glucagon-like peptide-1 receptor agonists for the management of obesity in adults without diabetes: A network meta-analysis of randomized clinical trials","authors":"Omar S. Alkhezi, Abdullah A. Alahmed, Osamah M. Alfayez, Osama A. Alzuman, Abdulaali R. Almutairi, Omar A. Almohammed","doi":"10.1111/obr.13543","DOIUrl":"https://doi.org/10.1111/obr.13543","url":null,"abstract":"<div>\u0000 \u0000 Tirzepatide is a new glucagon-like peptide-1 receptor agonist (GLP-1RA) that has shown promising results for weight loss. A Bayesian network meta-analysis was conducted to compare the efficacy and safety of GLP-1RAs for obesity management. Embase and MEDLINE were searched looking for randomized clinical trials (RCTs) that evaluated the efficacy of GLP-1RAs for weight loss in patients without diabetes. The main efficacy outcomes evaluated were the mean change in actual and percentage weight loss and the proportion of patients with weight loss of ≥5%–20%. Main safety outcomes evaluated include nausea, vomiting, diarrhea, constipation, loss of appetite, pancreatitis, gallbladder-related disorders, and withdrawal due to adverse events. Seven RCTs with more than 12,300 patients were analyzed, including patients with body mass index (BMI) ≥ 30 kg/m2, or BMI ≥ 27 kg/m2 with comorbidities. Weekly tirzepatide 10 and 15 mg resulted in more weight loss than weekly semaglutide 2.4 mg, daily semaglutide 0.4 mg, or liraglutide 3 mg. Tirzepatide and weekly semaglutide demonstrated comparable results but with significantly higher odds of achieving ≥5%–20% weight loss compared with liraglutide. GLP-1RAs triggered more gastrointestinal adverse events than placebo, with no in-between difference. Although all GLP-1RAs lead to significant weight reduction, tirzepatide was associated with better efficacy outcomes while having a comparable safety profile.\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 3","pages":""},"PeriodicalIF":8.9,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5860797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Distribution of energy intake across the day and weight loss: A systematic review and meta-analysis 一天中能量摄入的分布与体重减轻:一项系统回顾和荟萃分析

IF 8.9 2区医学

Obesity Reviews Pub Date : 2022-12-18 DOI: 10.1111/obr.13537

Isabel E. Young, Amudha Poobalan, Katharine Steinbeck, Helen T. O'Connor, Helen M. Parker

{"title":"Distribution of energy intake across the day and weight loss: A systematic review and meta-analysis","authors":"Isabel E. Young, Amudha Poobalan, Katharine Steinbeck, Helen T. O'Connor, Helen M. Parker","doi":"10.1111/obr.13537","DOIUrl":"https://doi.org/10.1111/obr.13537","url":null,"abstract":"Consuming a greater proportion of total energy intake earlier in the day rather than in the evening is proposed to positively influence weight loss and health, potentially due to greater synchronization of human body circadian rhythms. This systematic review provides an update on existing evidence regarding earlier distributed eating patterns in weight loss interventions. Using a robust search strategy in five electronic databases, nine randomized controlled trials investigating the impact of energy intake distribution on weight loss were identified. Following critical appraisal, a random-effects meta-analyses found that, in the context of an energy-reduced diet, distributing energy intake with a focus on earlier intake resulted in significantly greater weight loss (−1.23 kg; 95% CI 2.40, −0.06, p = 0.04). Improvements in HOMA-IR, fasting glucose, and LDL cholesterol were also seen. The current study provides a timely update on the evidence linking distribution of total daily energy intake and health, showing that a focus on earlier intakes can result in greater short-term weight loss compared with later intakes. Future studies are needed to elucidate the impact that earlier intakes may have on weight management and metabolic health.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 3","pages":""},"PeriodicalIF":8.9,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5711876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Association of fast-food restaurants with overweight and obesity in school-aged children and adolescents: A systematic review and meta-analysis 快餐店与学龄儿童和青少年超重和肥胖的关系:一项系统回顾和荟萃分析

IF 8.9 2区医学

Obesity Reviews Pub Date : 2022-12-15 DOI: 10.1111/obr.13536

Jun Jiang, Patrick W. C. Lau, Yanhui Li, Di Gao, Li Chen, Manman Chen, Ying Ma, Tao Ma, Qi Ma, Yi Zhang, Jieyu Liu, Xingxing Wang, Yanhui Dong, Yi Song, Jun Ma

{"title":"Association of fast-food restaurants with overweight and obesity in school-aged children and adolescents: A systematic review and meta-analysis","authors":"Jun Jiang, Patrick W. C. Lau, Yanhui Li, Di Gao, Li Chen, Manman Chen, Ying Ma, Tao Ma, Qi Ma, Yi Zhang, Jieyu Liu, Xingxing Wang, Yanhui Dong, Yi Song, Jun Ma","doi":"10.1111/obr.13536","DOIUrl":"https://doi.org/10.1111/obr.13536","url":null,"abstract":"<div>\u0000 \u0000 We aimed to explore associations between the accessibility of fast-food restaurants (FFRs) and weight-related outcomes in children and adolescents through a systematic review and meta-analysis of studies. We searched three databases for studies published before October 21, 2022. Study quality was assessed using the National Institutes of Health's Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Meta-analysis was performed, and the leave-one-out method was used for sensitivity analysis. A total of 60 studies were included. According to our analysis, FFRs within a smaller buffer radius from residences or that provide unhealthy foods may have a more significant influence on children's and adolescents' weight. Children of younger ages and girls may have a higher possibility of being overweight due to FFRs. Though we could hardly avoid bias, the estimates in low-and middle-income countries (only six studies) are much higher than those in high-income countries (54 studies). More research analyses based on microscope data and individual economic levels are needed. This study yields quantitative results, provides policymakers and urban planners with a theoretical support for building resilient and sustainable human settlements, and promotes the translation of research findings from public health to environmental planning.\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 3","pages":""},"PeriodicalIF":8.9,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6144835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Glucocorticoids, stress and eating: The mediating role of appetite-regulating hormones 糖皮质激素、压力和饮食:食欲调节激素的中介作用

IF 8.9 2区医学

Obesity Reviews Pub Date : 2022-12-08 DOI: 10.1111/obr.13539

Susanne Kuckuck, Eline S. van der Valk, Anton J. W. Scheurink, Bibian van der Voorn, Anand M. Iyer, Jenny A. Visser, Patric J. D. Delhanty, Sjoerd A. A. van den Berg, Elisabeth F. C. van Rossum

{"title":"Glucocorticoids, stress and eating: The mediating role of appetite-regulating hormones","authors":"Susanne Kuckuck, Eline S. van der Valk, Anton J. W. Scheurink, Bibian van der Voorn, Anand M. Iyer, Jenny A. Visser, Patric J. D. Delhanty, Sjoerd A. A. van den Berg, Elisabeth F. C. van Rossum","doi":"10.1111/obr.13539","DOIUrl":"https://doi.org/10.1111/obr.13539","url":null,"abstract":"Disrupted hormonal appetite signaling plays a crucial role in obesity as it may lead to uncontrolled reward-related eating. Such disturbances can be induced not only by weight gain itself but also by glucocorticoid overexposure, for example, due to chronic stress, disease, or medication use. However, the exact pathways are just starting to be understood. Here, we present a conceptual framework of how glucocorticoid excess may impair hormonal appetite signaling and, consequently, eating control in the context of obesity. The evidence we present suggests that counteracting glucocorticoid excess can lead to improvements in appetite signaling and may therefore pose a crucial target for obesity prevention and treatment. In turn, targeting hormonal appetite signals may not only improve weight management and eating behavior but may also decrease detrimental effects of glucocorticoid excess on cardio-metabolic outcomes and mood. We conclude that gaining a better understanding of the relationship between glucocorticoid excess and circulating appetite signals will contribute greatly to improvements in personalized obesity prevention and treatment.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 3","pages":""},"PeriodicalIF":8.9,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6185221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Assessing adolescents' readiness for action and attitudes toward obesity prevention: Instrument development and psychometric properties 评估青少年对预防肥胖的行动准备和态度:工具开发和心理测量特性

IF 8.9 2区医学

Obesity Reviews Pub Date : 2022-12-02 DOI: 10.1111/obr.13533

Navnit Kaur Grewal, Knut-Inge Klepp, Anna Banik, Christian Br?er, Helene Holb?k, Aleksandra Luszczynska, Talia Macauley, Harry Rutter, Nanna Lien

{"title":"Assessing adolescents' readiness for action and attitudes toward obesity prevention: Instrument development and psychometric properties","authors":"Navnit Kaur Grewal, Knut-Inge Klepp, Anna Banik, Christian Br?er, Helene Holb?k, Aleksandra Luszczynska, Talia Macauley, Harry Rutter, Nanna Lien","doi":"10.1111/obr.13533","DOIUrl":"https://doi.org/10.1111/obr.13533","url":null,"abstract":"Engaging adolescents in obesity prevention is a main objective of the CO-CREATE project. This paper presents the development of a questionnaire to assess readiness for action and attitudes toward obesity prevention among adolescents. The questionnaire was developed based on literature searches and internal discussions with experts in the CO-CREATE consortium. The questionnaire was translated, back translated, and pretested for time and comprehensiveness by adolescents from five countries (the Netherlands, Norway, Poland, Portugal, and the United Kingdom). Exploratory factor analysis was performed, and internal reliability of the resulting factors was determined using baseline data from Poland and Norway. Furthermore, test–retest reliability was assessed in a sample of Norwegian adolescents. The exploratory factor analysis on readiness for action identified four factors. Analysis on attitudes toward obesity prevention identified four factors on responsibility and five factors on drivers of behavior. Six of the factors had a Cronbach's alpha value above 0.70, five factors had a value between 0.60–0.70, whereas the remaining two factors were below 0.60. The test–retest correlation ranged from 0.46 to 0.87. The exploratory factor analyzes on readiness for action identified the same factors as hypothesized in the development of the questionnaire, whereas attitudes toward obesity prevention identified more factors than initially assumed. The questionnaire is considered reliable as a tool for measuring adolescents' readiness for action and attitudes toward obesity prevention.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 S1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6026560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Obesity in South and Southeast Asia—A new consensus on care and management 南亚和东南亚的肥胖问题——关于护理和管理的新共识

IF 8.9 2区医学

Obesity Reviews Pub Date : 2022-12-01 DOI: 10.1111/obr.13520

Kwang Wei Tham, Rohana Abdul Ghani, Sioksoan C. Cua, Chaicharn Deerochanawong, Mia Fojas, Samantha Hocking, June Lee, Tran Quang Nam, Faruque Pathan, Banshi Saboo, Sidartawan Soegondo, Noel Somasundaram, Alice M. L. Yong, John Ashkenas, Nicola Webster, Brian Oldfield

{"title":"Obesity in South and Southeast Asia—A new consensus on care and management","authors":"Kwang Wei Tham, Rohana Abdul Ghani, Sioksoan C. Cua, Chaicharn Deerochanawong, Mia Fojas, Samantha Hocking, June Lee, Tran Quang Nam, Faruque Pathan, Banshi Saboo, Sidartawan Soegondo, Noel Somasundaram, Alice M. L. Yong, John Ashkenas, Nicola Webster, Brian Oldfield","doi":"10.1111/obr.13520","DOIUrl":"https://doi.org/10.1111/obr.13520","url":null,"abstract":"Obesity is a chronic disease in which the abnormal or excessive accumulation of body fat leads to impaired health and increased risk of mortality and chronic health complications. Prevalence of obesity is rising rapidly in South and Southeast Asia, with potentially serious consequences for local economies, healthcare systems, and quality of life. Our group of obesity specialists from Bangladesh, Brunei Darussalam, India, Indonesia, Malaysia, Philippines, Singapore, Sri Lanka, Thailand, and Viet Nam undertook to develop consensus recommendations for management and care of adults and children with obesity in South and Southeast Asia. To this end, we identified and researched 12 clinical questions related to obesity. These questions address the optimal approaches for identifying and staging obesity, treatment (lifestyle, behavioral, pharmacologic, and surgical options) and maintenance of reduced weight, as well as issues related to weight stigma and patient engagement in the clinical setting. We achieved consensus on 42 clinical recommendations that address these questions. An algorithm describing obesity care is presented, keyed to the various consensus recommendations.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 2","pages":""},"PeriodicalIF":8.9,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13520","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5909182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Deciphering the “obesity paradox” in the elderly: A systematic review and meta-analysis of sarcopenic obesity 解读老年人的“肥胖悖论”:肌肉减少型肥胖的系统回顾和荟萃分析

IF 8.9 2区医学

Obesity Reviews Pub Date : 2022-11-28 DOI: 10.1111/obr.13534

Chaoran Liu, Pui Yan Wong, Yik Lok Chung, Simon Kwoon-Ho Chow, Wing Hoi Cheung, Sheung Wai Law, Juliana Chung Ngor Chan, Ronald Man Yeung Wong

{"title":"Deciphering the “obesity paradox” in the elderly: A systematic review and meta-analysis of sarcopenic obesity","authors":"Chaoran Liu, Pui Yan Wong, Yik Lok Chung, Simon Kwoon-Ho Chow, Wing Hoi Cheung, Sheung Wai Law, Juliana Chung Ngor Chan, Ronald Man Yeung Wong","doi":"10.1111/obr.13534","DOIUrl":"https://doi.org/10.1111/obr.13534","url":null,"abstract":"<div>\u0000 \u0000 Aging and obesity are two global concerns in public health. Sarcopenic obesity (SO), defined as the combination of age-related sarcopenia and obesity, has become a pressing issue. This systematic review and meta-analysis summarize the current clinical evidence relevant to SO. PubMed, Embase, and Web of Science were searched, and 106 clinical studies with 167,151 elderlies were included. The estimated prevalence of SO was 9% in both men and women. Obesity was associated with 34% reduced risk of sarcopenia (odds ratio [OR] 0.66, 95% CI 0.48–0.91; p < 0.001). The pooled hazard ratio (HR) of all-cause mortality was 1.51 (95% CI 1.14–2.02; p < 0.001) for people with SO compared with healthy individuals. SO was associated with increased risk of cardiovascular disease and related mortality, metabolic disorders, cognitive impairment, arthritis, functional limitation, and lung diseases (all ORs > 1.0, p < 0.05). The attenuated risk of sarcopenia in elderlies with obesity (“obesity paradox”) was dependent on higher muscle mass and strength. Apart from unifying the diagnosis of SO, more research is needed to subphenotype people with obesity and sarcopenia for individualized treatment. Meanwhile, the maintenance of proper body composition of muscle and fat may delay or attenuate the adverse outcomes of aging.\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"24 2","pages":""},"PeriodicalIF":8.9,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5855538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19