Obesity Reviews最新文献

{"title":"Obesity Remission: A Missing Target in Contemporary Medicine","authors":"Theocharis Koufakis,&nbsp;Alexander Kokkinos,&nbsp;Luca Busetto,&nbsp;Carel W. le Roux","doi":"10.1111/obr.70197","DOIUrl":"10.1111/obr.70197","url":null,"abstract":"<div>\u0000 \u0000 <p>Obesity is a chronic disease associated with substantial cardiometabolic, mechanical, and psychosocial burden, contributing significantly to global morbidity and mortality. Despite its impact, therapeutic strategies remain disproportionately conservative, often delaying effective intervention. In contrast, treatment algorithms for other chronic diseases, such as type 2 diabetes and rheumatoid arthritis, have adopted remission-oriented approaches aimed at suppressing disease activity rather than merely attenuating progression. In this context, we propose a remission-oriented paradigm for obesity. Remission is defined as a sustained, multidimensional state characterized by the achievement of clinically meaningful adiposity targets, alleviation of obesity-related complications, restoration of functional capacity, and improvement in psychological well-being. Importantly, remission is conceptualized as a continuum, analogous to glycemic states, and may be maintained with ongoing pharmacotherapy. We further propose an induction–remission–maintenance model that prioritizes early, effective intervention. This framework explicitly acknowledges the chronic nature of the disease of obesity, even in the presence of potent therapies, underscoring the need for ongoing monitoring and long-term disease surveillance. Despite challenges related to access, cost, and long-term adherence, this approach offers a structured, disease-centered model with the potential to improve clinical outcomes and reduce healthcare burden.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 9","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photovoice as a Methodology in Obesity Research: A Scoping Review","authors":"Olumuyiwa Omonaiye,&nbsp;Jaithri Ananthapavan,&nbsp;Martin Hensher,&nbsp;Thi Thu Ngan Dinh,&nbsp;Fiona Pazsa,&nbsp;Sharon Neale,&nbsp;Danielle Hitch","doi":"10.1111/obr.70180","DOIUrl":"10.1111/obr.70180","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Photovoice is a community-based participatory research methodology that empowers participants to document and reflect on their lived experiences through photography. This scoping review examines the use of Photovoice in obesity research to explore the contexts in which it has been used, its application, and key themes in the literature to date.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eligible studies were peer-reviewed primary research published since 1997 that used Photovoice (with the process described) to collect empirical data from people with lived experience of obesity as the primary focus and were available in English, French, or Portuguese. Following the Joanna Briggs Institute guidelines, a systematic search was conducted in six databases, yielding 387 records, with 32 studies meeting the inclusion criteria. Key data, including study location, participant demographics, Photovoice methodology, and findings, were extracted and synthesized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most studies were conducted in North America within community settings, predominantly with minority populations. Four key themes emerged: environmental influences, facilitators and barriers to healthy living, mental health and well-being, and perceptions of obesity. Although findings align with other research methodologies, Photovoice uniquely highlights participant voices and fosters critical community engagement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Photovoice is a valuable tool for obesity research, amplifying participant perspectives and contextual insights in ways more traditional methods may overlook. Future research should expand geographic and demographic diversity and adapt Photovoice for virtual formats to broaden its accessibility and explore its impact on participants, policy, and practice change.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 9","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.70180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep and Its Impact on the Success of Weight Loss Interventions in Adults With Excess Weight: A Systematic Review","authors":"Lauren Duan,&nbsp;Jessica Berryhill,&nbsp;Nichole Dai,&nbsp;Gabrielle Sica,&nbsp;Jean-Philippe Chaput","doi":"10.1111/obr.70199","DOIUrl":"10.1111/obr.70199","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate evidence on the impact of sleep health on weight loss in adults with excess weight undergoing behavioral or surgical weight loss interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic review of randomized controlled trials and quasi-experimental studies including adults aged ≥ 18 years with BMI ≥ 25 kg/m². MEDLINE, Embase, and CENTRAL were searched from inception to September 2025. Screening, data extraction, and risk of bias assessment were performed in duplicate. Sleep was examined either as an exposure or as an intervention component. A narrative synthesis was conducted using the RU-SATED framework and stratified by sleep exposure versus sleep intervention studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty studies (13 randomized controlled trials and 17 quasi-experimental studies; 10,944 participants from 13 countries) were included. Evidence was mixed across sleep dimensions. In behavioral weight loss interventions, sleep manipulation studies suggested that sleep restriction reduced fat loss, whereas observational studies reported inconsistent associations between sleep duration and weight loss. Limited evidence suggested that greater sleep satisfaction and higher sleep efficiency may support weight loss, with approximately half of the studies reporting positive associations. Evidence for sleep regularity, timing, and alertness was sparse and inconsistent because of the small number of studies and methodological heterogeneity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sleep satisfaction and sleep efficiency may support weight loss in behavioral interventions, whereas sleep duration shows inconsistent associations and sleep restriction may impair fat loss. Evidence for sleep regularity, timing, and alertness remains limited. High-quality experimental studies are needed to clarify the causal role of sleep health in weight loss outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 9","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.70199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Presentation","authors":"","doi":"10.1111/obr.70191","DOIUrl":"https://doi.org/10.1111/obr.70191","url":null,"abstract":"","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 S1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Presentation","authors":"","doi":"10.1111/obr.70192","DOIUrl":"https://doi.org/10.1111/obr.70192","url":null,"abstract":"","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 S1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Mental Health: A Missing Piece in the Puzzle.","authors":"Natasha Kim de Oliveira da Fonseca, Elisa Brietzke, Gisele Gus Manfro","doi":"10.1111/obr.70205","DOIUrl":"https://doi.org/10.1111/obr.70205","url":null,"abstract":"<p><p>Psychiatric disorders are highly prevalent among individuals living with obesity and contribute to treatment resistance, poor adherence, and adverse health outcomes. Yet, obesity management often remains fragmented, with limited integration between endocrinology, psychiatry, and behavioral health. This Perspective advocates for a mental health framework for obesity care. We emphasize the need for future investigations to test the clinical relevance of behavioral phenotyping as a complementary approach to pharmacotherapy, including GLP-1 receptor agonists, to enhance treatment personalization. By reframing obesity as a disease deeply intertwined with mental health, we emphasize the need for multidisciplinary care models that incorporate psychological assessment, stigma reduction, and patient-centered nutrition counseling. Advancing this framework will require closer collaboration between medical and mental health disciplines and greater investment in neurobehavioral research to improve long-term outcomes in obesity care.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70205"},"PeriodicalIF":7.6,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Obesity Interventions in Primary Health Care: Protocol for a Scoping Review of Barriers and Enablers","authors":"Sandra León-Herrera, Ileana Gefaell, Marina Guisado-Clavero, Marta Sánchez-Castro, Leda Nemer, Mª Pilar Rodríguez-Pérez, Charlotte Leonie Gebhardt, Inês da Silva E Pereira, Vinicius Anjos de Almeida, Sıdıka Ece Yokuş, Özden Gökdemir, Nicola Buono, Ferdinando Petrazzuoli, María Pilar Astier-Peña, Sara Ares-Blanco, Raquel Gómez-Bravo","doi":"10.1111/obr.70206","DOIUrl":"10.1111/obr.70206","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a major public health challenge worldwide, driving chronic disease and health care costs. Primary health care (PHC) is a key setting for prevention, early identification, and management of obesity, yet implementation of evidence-based interventions remains limited. Identifying the barriers and enablers that influence adoption of obesity care in PHC is critical to strengthen delivery.</p><p><strong>Objective: </strong>This scoping review will systematically map and synthesize barriers and enablers to implementing obesity interventions in PHC, considering behavioral, nutritional, pharmacological, digital, and organizational approaches, across both adult and pediatric populations.</p><p><strong>Methods: </strong>The review will follow the Joanna Briggs Institute (JBI) methodology and be reported according to PRISMA-ScR guidelines. Searches will be conducted in PubMed, Cochrane Library, Scopus, Web of Science, and ScienceDirect, complemented by gray literature from OpenGrey, ResearchGate, Google Scholar, and organizational websites. Eligible sources will include peer-reviewed and gray literature published between 2019 and 2025 in English, French, German, Italian, Portuguese, Spanish, or Turkish. Two reviewers will independently screen, extract, and analyze data, with discrepancies resolved by consensus. Data will be synthesized descriptively and thematically, supported by NVivo, and results presented in tables, thematic maps, and conceptual diagrams. Expected Results Anticipated barriers include time constraints, limited provider training, stigma, scarce resources, and inadequate reimbursement models. Enablers are expected to include supportive health policies, training, patient engagement strategies, and team-based care models.</p><p><strong>Conclusions: </strong>This review will synthesize implementation factors affecting obesity care in PHC, informing scalable strategies and policy to improve obesity management worldwide.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70206"},"PeriodicalIF":7.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Prevalence and Clinical Relevance of Health Literacy in Severe Obesity: A Scoping Review.","authors":"Andrea Xia, Supreet Saluja, Danielle M Muscat, Philayrath Phongsavan, Kate McBride, Kathryn Williams","doi":"10.1111/obr.70201","DOIUrl":"https://doi.org/10.1111/obr.70201","url":null,"abstract":"<p><p>Recent studies suggest that health literacy (HL) may play an important role in management of individuals living with severe obesity (BMI ≥ 40 kg/m²), but to date, there has been no attempt to synthesize characteristics and outcomes of these studies. To explore the prevalence of low HL in people with severe obesity, and how HL may impact on health outcomes and management of severe obesity, six databases and two independent journals were searched. Seventeen studies were included in this review, mostly undertaken in high income countries, among females and candidates of bariatric surgery. Low HL ranged from 3.7% to 57.9% in cohorts studied, possibly explained by the heterogeneity of HL tools (i.e., seven different validated tools). Eight studies found higher HL to lead to better treatment outcomes (e.g., weight loss, attending appointments). Thematic synthesis of qualitative studies identified a lack of access to health information and support from healthcare providers (domains of HL) as barriers in improving health in patients with severe obesity. There is notable gap in interventional studies on improving HL in people with severe obesity. Overall, HL seems to be an important predictor of health outcomes in management of severe obesity. Further research is needed to assess the impact of HL on a broader range of health outcomes in nonsurgical patients with severe obesity.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70201"},"PeriodicalIF":7.6,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incretin-Based Medications in Women and Reproduction: A Systematic Scoping Review and Consensus Guidelines for Clinical Practice.","authors":"Kate Maslin, Jill Shawe, Sinead Blowers, Michael Ceulemans, Kathryn Hart, Sam Schoenmakers, Amihai Rottenstreich, Heather Hopper, Mojca Jensterle, Angela C Flynn, Sarah Siegelaar, Annick Bogaerts, Isy Douek, Nicola Heslehurst, Dries Ceulemans, Tricia Tan, Johnathan Pinkney, Martin Whyte, Shahrad Taheri, Roland Devlieger","doi":"10.1111/obr.70203","DOIUrl":"https://doi.org/10.1111/obr.70203","url":null,"abstract":"<p><strong>Introduction: </strong>Pregnancy concurrent with incretin-based medications is contraindicated due to unknown risk of teratogenicity, as is breastfeeding. The aim of this systematic scoping review was to investigate potential risks and benefits of incretin-based medications in relation to preconception, pregnancy, and postnatal health, and to propose expert guidelines for clinical practice.</p><p><strong>Methods: </strong>An international expert multidisciplinary group was formed. Research questions relevant to women's reproductive health and incretin-based medications were refined collaboratively, utilizing a lifecourse approach. A systematic search was undertaken on July 23, 2025, across several databases and grey literature sources. Primary data from human studies were prioritized above animal studies. Titles, abstracts, and full text articles were screened independently by two authors. Data were extracted by two people independently using a pre-defined proforma and synthesized narratively. Consensus recommendations were made.</p><p><strong>Results: </strong>Thirty-four articles were included in the evidence synthesis: 11 randomized trials, nine observational studies, two pharmacovigilance reviews, nine case reports/series, two animal studies, and one ex vivo study. No qualitative studies were identified. Evidence was found for 18/32 (56.3%) research questions. Most studies related to preconception or pregnancy usage; two addressed contraception, and one was about lactation. The sample size of exposed pregnancies ranged from 1 to 4267. Three studies reported exposure throughout pregnancy. Three studies investigated postpartum usage. One (animal) study had offspring data beyond birth. No studies reported an increase in congenital anomalies.</p><p><strong>Conclusion: </strong>Clinical practice and research recommendations were made based on current available evidence and evidence gaps, encompassing contraception, preconception, nutritional, pregnancy monitoring, lactation, and longer-term outcomes.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70203"},"PeriodicalIF":7.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148617611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity-Paving the Way for Targeted Clinical Intervention Trials-A Comprehensive Position Paper.","authors":"Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela E Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat-Mesquida, Maria Pérez-Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn-Haren, Rikke Andersen, Torsten Bohn","doi":"10.1111/obr.70175","DOIUrl":"10.1111/obr.70175","url":null,"abstract":"<p><p>Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences for the individual and society at large are drastic. Therefore, it is crucial to understand and predict who is at risk of developing obesity in order to implement early prevention strategies. Many individual risk factors have been emphasized. However, as obesity is a rather multifactorial complication, single markers/biomarkers have thus far not allowed for an efficient prediction of obesity. In addition to less modifiable parameters, such as environment and socio-demographics, studies have revealed that obesity is related to several interacting aspects, including host factors such as genetics/epigenetics or gut microbiota, and more readily modifiable factors, including nutrition and physical activity, as well as sleep patterns and psychological well-being. It is likely that combining markers from across different domains, that is, multimodal markers, allows for better predictability for the risk of developing obesity. However, it must be considered that not all markers are fully predictive; many are rather reactive or even both. In this review and position paper, we emphasize the state-of-the-art regarding (bio)markers that have successfully been employed for predicting obesity risk. An emphasis will rest on novel, emerging biomarkers, and the need for a more integrative, multimodal assessment of obesity risk for a combined assessment aimed at improving risk prediction.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70175"},"PeriodicalIF":7.6,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148596847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}