Obesity Reviews最新文献

{"title":"Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning","authors":"Mark I. Friedman,&nbsp;Thorkild I. A. Sørensen,&nbsp;Gary Taubes,&nbsp;Jens Lund,&nbsp;David S. Ludwig","doi":"10.1111/obr.13795","DOIUrl":"10.1111/obr.13795","url":null,"abstract":"<p>Our understanding of the pathophysiology of obesity remains at best incomplete despite a century of research. During this time, two alternative perspectives have helped shape thinking about the etiology of the disorder. The currently prevailing view holds that excessive fat accumulation results because energy intake exceeds energy expenditure, with excessive food consumption being the primary cause of the imbalance. The other perspective attributes the initiating cause of obesity to intrinsic metabolic defects that shift fuel partitioning from pathways for mobilization and oxidation to those for synthesis and storage. The resulting reduction in fuel oxidation and trapping of energy in adipose tissue drives a compensatory increase in energy intake and, under some conditions, a decrease in expenditure. This theory of obesity pathogenesis has historically garnered relatively less attention despite its pedigree. Here, we present an updated comprehensive formulation of the fuel partitioning theory, focused on evidence gathered over the last 80 years from major animal models of obesity showing a redirection of fuel fluxes from oxidation to storage and accumulation of excess body fat with energy intake equal to or even less than that of lean animals. The aim is to inform current discussions about the etiology of obesity and by so doing, help lay new foundations for the design of more efficacious approaches to obesity research, treatment and prevention.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 10","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ultraprocessed food consumption and excess adiposity in children and adolescents: A systematic review","authors":"Brenda Robles,&nbsp;Anna Mota-Bertran,&nbsp;Marc Saez,&nbsp;Marta Solans","doi":"10.1111/obr.13796","DOIUrl":"10.1111/obr.13796","url":null,"abstract":"<p>Ultraprocessed foods (UPF) consumption is associated with excess adiposity in adults, but this linkage remains unclear among children and adolescents. The present systematic review sought to address this research gap. Publications up to November 2023 were retrieved from PubMed, Web of Science, and Scopus databases. Outcomes included overweight/obesity anthropometric and body composition indicators; the exposure was UPF consumption based on the NOVA classification system. The review included 23 studies (i.e., 8 cohort and 15 cross-sectional); approximately half were carried out in Brazil. Inconclusive and heterogeneous evidence exists as few cohort studies found positive/mixed associations between UPF consumption and excess adiposity in pediatric populations, whereas most cross-sectional studies reported null associations. Such inconsistencies may be attributed to underlying methodological issues, especially heterogeneity in the outcomes assessed and UPF consumption operationalization and/or categorization. Future studies should adopt longitudinal designs with sufficiently extended follow-up periods, account for relevant confounding factors, employ validated and standardized measurement tools to assess dietary exposure, ensure consistent operationalization of variables, and encompass diverse geographic contexts. Ultimately, strengthening the quality of existing research evidence may better inform current and forthcoming policy and practice interventions aimed at mitigating the increasing prevalence of overweight/obesity in childhood and across the life course.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 10","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical semiology of patients with monogenic obesity: A systematic review","authors":"Emeline Renard,&nbsp;Ariane Thevenard-Berger,&nbsp;David Meyre","doi":"10.1111/obr.13797","DOIUrl":"10.1111/obr.13797","url":null,"abstract":"<p>Patients with monogenic obesity display numerous medical features on top of hyperphagic obesity, but no study to date has provided an exhaustive description of their semiology. Two reviewers independently conducted a systematic review of MEDLINE, Embase, and Web of Science Core Collection databases from inception to January 2022 to identify studies that described symptoms of patients carrying pathogenic mutations in at least one of eight monogenic obesity genes (<i>ADCY3</i>, <i>LEP</i>, <i>LEPR</i>, <i>MC3R</i>, <i>MC4R</i>, <i>MRAP2</i>, <i>PCSK1</i>, and <i>POMC</i>). Of 5207 identified references, 269 were deemed eligible after title and abstract screening, full-text reading, and risk of bias and quality assessment. Data extraction included mutation spectrum and mode of inheritance, clinical presentation (e.g., anthropometry, energy intake and eating behaviors, digestive function, puberty and fertility, cognitive features, infectious diseases, morphological characteristics, chronic respiratory disease, and cardiovascular disease), biological characteristics (metabolic profile, endocrinology, hematology), radiological features, and treatments. The review provides an exhaustive description of mandatory, non-mandatory, and unique symptoms in heterozygous and homozygous carriers of mutation in eight monogenic obesity genes. This information is critical to help clinicians to orient genetic testing in subsets of patients with suspected monogenic obesity and provide actionable treatments (e.g., recombinant leptin and MC4R agonist).</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 10","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which components of behavioral weight management programs are essential for weight loss in people living with obesity? A rapid review of systematic reviews","authors":"Lily K. Hawkins,&nbsp;Lorna Burns,&nbsp;Dawn Swancutt,&nbsp;Shokraneh Moghadam,&nbsp;Jonathan Pinkney,&nbsp;Mark Tarrant,&nbsp;The PROGROUP Programme Team","doi":"10.1111/obr.13798","DOIUrl":"10.1111/obr.13798","url":null,"abstract":"<p>The optimal treatment and organization of care for people with obesity is one of the greatest challenges facing today's health services. While surgery and pharmacotherapy offer effective treatment options for some people with obesity, behavioral interventions are important to support long-term behavioral change. However, little is known about the most effective components of behavioral interventions, and this is especially the case for people with complex or severe obesity (i.e. body mass index [BMI] &gt; 35 kg/m²). Accordingly, the current rapid review aimed to identify which behavior change techniques (BCTs) are effective for weight loss in adults with (severe) obesity. A secondary aim was to review the effects of BCTs on dietary behaviors and physical activity, and psychological outcomes, recognizing that behavioral interventions commonly target these. A search of Scopus, Ovid Medline, and Web of Science resulted in 1227 results, with 22 reviews eligible for inclusion. The most commonly reported BCTs were self-monitoring and goal setting, but these had variable effects on weight in adults with obesity. Combining these BCTs with other self-regulatory techniques led to increased weight loss. Further, for adults with severe obesity, so-called ‘nudge’ techniques and self-regulatory techniques were associated with greater weight loss. Three reviews also found that while self-monitoring increased physical activity, behavioral commitments increased changes to dietary behaviors. BCTs were not associated with psychological well-being. The review confirms that behavioral interventions have an impact in weight management, including for individuals with more complex or severe obesity, but highlights the need for further investigation of their use within clinical settings.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 10","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13798","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Presentations","authors":"","doi":"10.1111/obr.13787","DOIUrl":"10.1111/obr.13787","url":null,"abstract":"&lt;p&gt;&lt;b&gt;O01&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Bisphenols impairs liver metabolism and morphology in male C57BL/6 mice independent of a high-fat diet and induces hepatocyte toxicity in human huh-7 hepatoma cells&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Vinicius Sepúlveda Fragoso&lt;/span&gt;&lt;sup&gt;1&lt;/sup&gt;, Emanuelle Barreto dos Reis&lt;sup&gt;2&lt;/sup&gt;, Thais de Souza Carvalho Laureano&lt;sup&gt;2&lt;/sup&gt;, Beatriz Alexandre-santos&lt;sup&gt;2&lt;/sup&gt;, Emma de Juan Barroso Fernández&lt;sup&gt;3&lt;/sup&gt;, Manuel Vázquez-carrera&lt;sup&gt;3&lt;/sup&gt;, Milena Barcza Stockler-pinto&lt;sup&gt;2&lt;/sup&gt;, Leandro Miranda-alves&lt;sup&gt;1&lt;/sup&gt;, Eliete Dalla Corte Frantz&lt;sup&gt;2&lt;/sup&gt; and D'angelo Carlo Magliano&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;Federal University of Rio de Janeiro;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Fluminense Federal University;&lt;/i&gt; &lt;sup&gt;3&lt;/sup&gt;&lt;i&gt;University of Barcelona&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;INTRODUCTION:&lt;/b&gt; Metabolic-associated fatty liver disease (MAFLD) is the most common liver disorder worldwide, strongly associated with the obesity epidemic. Bisphenols, a class of endocrine disrupting chemicals (EDC) used in the plastic industry, have been shown to present obesogenic activity. Bisphenol S (BPS) is the major substitute of bisphenol A - most used bisphenol in the last decades - and has been presented as a safer option, but recent studies have shown it might also act on the development of obesity. Therefore, we aim to compare the effects of different doses of BPS exposure in the liver of C57BL/6 mice fed a standard or a high-fat diet, as well as different concentrations of BPS in Huh-7 cells pre-treated or not with palmitate.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIAL AND METHODS:&lt;/b&gt; (CEUA 1929240521) C57BL/6 mice (3-mo-old) were divided into 4 groups fed a standard-chow (SC) diet and 4 groups fed a high-fat (HF) diet: SC; SCB4 (standard chow animals exposed to 4 μg/kg/day of BPS); SCB25 (25 μg/kg/day of BPS); and SCB50 (50 μg/kg/day of BPS). HF; HFB4 (high-fat diet animals exposed to 4 μg/kg/day of BPS); HFB25 (25 μg/kg/day of BPS); and HFB50 (50 μg/kg/day of BPS). The protocol lasted for 12 weeks. BPS was added to the drinking water. Food, water and energy intake, glucose tolerance (through oral glucose tolerance test-OGTT) and body mass, as well as hepatic mass, cholesterol and triglycerides content, and histology were evaluated. Human Huh-7 hepatoma cells were exposed to BPS (10, 50, 100, 200, or 400 μM) with or without palmitate (50 μM) for 24 h. Data presented as mean±standard deviation and analyzed by one-way ANOVA with Holm-Sidak post-hoc test (p &lt; 0,05).&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; In mice, SCB4 and SCB25 groups presented higher body mass at the end of the protocol compared to both SC and SCB50 groups. In HF-fed groups, HFB4 and HFB50 decreased final body mass in comparison to HF and HFB25 groups. The area under curve of OGTT was higher in SCB25 group in comparison to SC and lower in HFB4 and HFB50 when compared to HF group. Liver mass, hepatic cholesterol, and stereology-quantified percentage of steatosis were higher in all SC-fed interventions in relation to SC group, but only SCB25 gro","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 S1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Exibitions","authors":"","doi":"10.1111/obr.13788","DOIUrl":"https://doi.org/10.1111/obr.13788","url":null,"abstract":"&lt;p&gt;&lt;b&gt;P001&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Empirically derived dietary patterns and obesity among women living in urban and rural areas of Southwest Iran&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;span&gt;Arezoo Rezazadeh&lt;/span&gt;, Razieh Hassanpor and Bahram Rashidkhani&lt;/p&gt;&lt;p&gt;&lt;i&gt;Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;BACKGROUND:&lt;/b&gt; The pattern of dietary intake reflects the preferences and dietary habits of individuals and their socioeconomic and lifestyle status. The aim of this study is to identify major dietary patterns (DPs) and their association with obesity in women from urban and rural areas of Dashtestan County, Southwest Iran.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS:&lt;/b&gt; In this cross-sectional study, 302 (168 urban and 134 rural women) aged 20-59 years old living in Dashtestan County were sampled with multiple-stage cluster sampling method. Through a face-to-face interview method, dietary intake was assessed with a standard semi-quantitative food frequency questionnaire whose content validity was approved in the studied population. Weight, height, and waist circumference (WC) were measured with standard methods, and body mass index (BMI) was calculated. General obesity was defined as BMI ≥ 30 kg/m&lt;sup&gt;2&lt;/sup&gt; and central obesity as WC &gt; 88 cm. The principal component analysis method was used for identifying major dietary patterns. The associations between major dietary patterns and general and central obesity were assessed by logistic regression analysis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Three major DPs were extracted: healthy (highly loaded for vegetables, fruits and natural juices, garlic, low-fat dairy products, olives, beans, fish and shrimps, nuts, all kinds of chickens, coffee), Western (sweets and desserts, salty snacks, sauces, soft drinks, pickles, salty and salt, fast food, high-fat dairy products, red and processed meat, industrial juices, whole grains), and traditional (dates, bulgur, potatoes, eggs, traditional breads, hydrogenated oils). The score of the Western pattern was significantly higher in urban women (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). The score of other patterns did not have a significant difference between urban and rural areas. Mean and standard deviation of BMI and the point prevalence of underweight, overweight, and obesity were not significantly different between the two urban and rural groups. However, the point prevalence of central obesity was significantly higher in rural women (41.7%) in comparison with their counterpart (32.9%). In rural women, those who were at the highest tertile of a healthy eating pattern had a lower chance of developing general obesity and abdominal obesity compared to the first tertile. After adjustment for confounders (energy intake and physical activity), in both groups, those at the highest tertile of Western and traditional DPs had a higher chance of central obesity. However, after further adjust","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 S1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13788","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial puzzle in muscle: Linking the electron transport system to overweight","authors":"Rafael A. Casuso","doi":"10.1111/obr.13794","DOIUrl":"10.1111/obr.13794","url":null,"abstract":"<div>\u0000 \u0000 <p>Human skeletal muscle mitochondria regulate energy expenditure. Research has shown that the functionality of muscle mitochondria is altered in subjects with overweight, as well as in response to nutrient excess and calorie restriction. Two metabolic features of obesity and overweight are (1) incomplete muscular fatty acid oxidation and (2) increased circulating lactate levels. In this study, I propose that these metabolic disturbances may originate from a common source within the muscle mitochondrial electron transport system. Specifically, a reorganization of the supramolecular structure of the electron transport chain could facilitate the maintenance of readily accessible coenzyme Q pools, which are essential for metabolizing lipid substrates. This approach is expected to maintain effective electron transfer, provided that there is sufficient complex III to support the Q-cycle. Such an adaptation could enhance fatty acid oxidation and prevent mitochondrial overload, thereby reducing lactate production. These insights advance our understanding of the molecular mechanisms underpinning metabolic dysregulation in overweight states. This provides a basis for targeted interventions in the quest for metabolic health.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 9","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of once-weekly subcutaneous semaglutide on weight loss in patients with overweight or obesity without diabetes mellitus—A systematic review and meta-analysis of randomized controlled trials","authors":"Sharath Kommu,&nbsp;Richard L. Berg","doi":"10.1111/obr.13792","DOIUrl":"10.1111/obr.13792","url":null,"abstract":"<p>Semaglutide is found to be efficient for weight loss in patients with overweight or obesity with diabetes mellitus (DM). With a wide range of adverse events reported, the efficacy and safety of once-weekly subcutaneous semaglutide in individuals without DM, with overweight or obesity, is unclear. We conducted a comprehensive meta-analysis of randomized studies on once-weekly semaglutide in this patient population. We identified nine studies with 11,641 patients in the semaglutide group and 10,479 in the placebo group. We observed that semaglutide resulted in significant benefits, including change in body weight (%): mean difference (MD) of −11.49% (<i>p</i> &lt; 0.0001), change in absolute body weight: MD of −11.74 kg (<i>p</i> &lt; 0.0001), and change in waist circumference: MD of −9.06 cm (<i>p</i> &lt; 0.0001). Gastrointestinal side effects are predominant including nausea: odds ratio (OR) of 4.06 (<i>p</i> &lt; 0.0001), vomiting: OR of 4.43 (<i>p</i> &lt; 0.0001), diarrhea: OR of 2.10 (<i>p</i> &lt; 0.0001), constipation: OR of 2.43 (<i>p</i> &lt; 0.0001), gallbladder disorders: OR of 1.26 (<i>p</i> = 0.010), and cholelithiasis: OR of 2.06 (<i>p</i> = 0.04). Serious adverse events were not statistically significant: OR of 1.06 (<i>p</i> = 0.82). However, the percentage of participants discontinuing due to adverse events and gastrointestinal side effects was statistically significant: ORs of 2.22 (<i>p</i> &lt; 0.0001) and 3.77 (<i>p</i> &lt; 0.0001), respectively. This study shows that in patients with overweight or obesity without DM, once-weekly subcutaneous semaglutide can significantly decrease body weight without risk of serious adverse events when compared with a placebo. However, gastrointestinal side effects are predominant with semaglutide, which can result in medication discontinuation.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 9","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13792","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of metabolic and bariatric surgery on the obesity pandemic in Latin America: A review of current practices and future directions","authors":"Luis D. Castellanos,&nbsp;Paola Anselmetti,&nbsp;Arnaldo J Acosta G,&nbsp;Daniel Tomey,&nbsp;Robert Araujo-Contreras,&nbsp;Emiro Puche,&nbsp;Steven Elzein,&nbsp;Yitka Graham,&nbsp;Kamal Mahawar,&nbsp;Skye Marshall,&nbsp;Adel Abou-Mrad,&nbsp;Rodolfo J. Oviedo","doi":"10.1111/obr.13793","DOIUrl":"10.1111/obr.13793","url":null,"abstract":"<div>\u0000 \u0000 <p>Latin America faces a significant public health challenge due to the high prevalence of obesity and its associated diseases. Metabolic and bariatric surgery is effective and safe to treat obesity when other treatments fail; however, its implementation in Latin America remains unsatisfactory. This review explores the current status, challenges, and innovations of metabolic and bariatric surgery in Latin America. We searched peer-reviewed journals in English and Spanish for relevant articles published between 1998 and 2023. We found that more than 20% of the Latin American population is affected by obesity. Unfortunately, only a limited number of patients have access to metabolic and bariatric surgery due to high cost, limited availability, and shortage of specialists. The review found that ongoing clinical trials are being conducted in Brazil, Mexico, Chile, and Venezuela, indicating some regional progress. However, published studies remain low in number compared with other regions. Furthermore, we summarized the clinical outcomes, risks, and perioperative assessments associated with metabolic and bariatric surgery. We discussed potential strategies to enhance the availability and affordability of this intervention. This review emphasizes the significance of metabolic and bariatric surgery in addressing the obesity pandemic, specifically for Latin America, and proposes directions for future research and innovation.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 9","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-specific roles of mitochondrial unfolded protein response during obesity","authors":"Fernanda S. Carneiro,&nbsp;Carlos K. Katashima,&nbsp;Joshua D. Dodge,&nbsp;Dennys E. Cintra,&nbsp;José Rodrigo Pauli,&nbsp;Adelino S. R. Da Silva,&nbsp;Eduardo R. Ropelle","doi":"10.1111/obr.13791","DOIUrl":"10.1111/obr.13791","url":null,"abstract":"<p>Obesity is a worldwide multifactorial disease caused by an imbalance in energy metabolism, increasing adiposity, weight gain, and promoting related diseases such as diabetes, cardiovascular diseases, neurodegeneration, and cancer. Recent findings have reported that metabolic stress related to obesity induces a mitochondrial stress response called mitochondrial unfolded protein response (UPR^mt), a quality control pathway that occurs in a nuclear DNA–mitochondria crosstalk, causing transduction of chaperones and proteases under stress conditions. The duality of UPR^mt signaling, with both beneficial and detrimental effects, acts in different contexts depending on the tissue, cell type, and physiological states, affecting the mitochondrial function and efficiency and the metabolism homeostasis during obesity, which remains not fully clarified. Therefore, this review discusses the most recent findings regarding UPR^mt signaling during obesity, bringing an overview of UPR^mt across different metabolic tissues.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"25 9","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}