Obesity Reviews最新文献

筛选
英文 中文
Molecular mechanisms of the obesity associated with Bardet-Biedl syndrome: An update 与巴尔德-比德尔综合征相关的肥胖症的分子机制:最新进展。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-30 DOI: 10.1111/obr.13859
Bang-Hua Zhong, Ning Nie, Ming Dong
{"title":"Molecular mechanisms of the obesity associated with Bardet-Biedl syndrome: An update","authors":"Bang-Hua Zhong,&nbsp;Ning Nie,&nbsp;Ming Dong","doi":"10.1111/obr.13859","DOIUrl":"10.1111/obr.13859","url":null,"abstract":"<div>\u0000 \u0000 <p>Obesity is a prominent feature of Bardet-Biedl syndrome (BBS), which represents a major and growing public health problem. More than half of BBS patients carry mutations in one of eight genes that encode subunits of a protein complex known as the BBSome, which has emerged as a key regulator of energy and glucose homeostasis. However, the mechanisms underlying obesity in BBS are complex. Numerous studies have identified a high prevalence of insulin resistance and metabolic syndrome among individuals with BBS. However, the exact mechanisms are not fully understood. This review summarized evidence from experiments using mouse and cell models, focusing on the energy imbalance that leads to obesity in patients with BBS. The studies discussed in this review contribute to understanding the functional role of the BBSome in the obesity associated with BBS, laying the foundation for developing new preventive or therapeutic strategies for obese patients.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding barriers and facilitators to lifestyle management in people with polycystic ovary syndrome: A mixed method systematic review 了解多囊卵巢综合征患者生活方式管理的障碍和促进因素:混合方法系统综述。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-27 DOI: 10.1111/obr.13854
Margaret McGowan, Rhonda Garad, Girija Wadhwani, Sophia Torkel, Vibhuti Rao, Alison Maunder, Elaine K. Osei-Safo, Lisa J. Moran, Stephanie Cowan
{"title":"Understanding barriers and facilitators to lifestyle management in people with polycystic ovary syndrome: A mixed method systematic review","authors":"Margaret McGowan,&nbsp;Rhonda Garad,&nbsp;Girija Wadhwani,&nbsp;Sophia Torkel,&nbsp;Vibhuti Rao,&nbsp;Alison Maunder,&nbsp;Elaine K. Osei-Safo,&nbsp;Lisa J. Moran,&nbsp;Stephanie Cowan","doi":"10.1111/obr.13854","DOIUrl":"10.1111/obr.13854","url":null,"abstract":"<div>\u0000 \u0000 <p>Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 10–13% of reproductive-aged women. Lifestyle management through diet and physical activity changes can improve reproductive, metabolic, and psychological comorbidities. The aim of this systematic review is to understand the barriers and facilitators to lifestyle changes from the perspective of people with PCOS and health care professionals (HCP) using the theoretical domains framework and capability, opportunity, motivation, and behavior model. Six databases were systematically searched for qualitative, quantitative, and mixed-methods studies to 22nd September 2022. Quantitative outcomes from quantitative and mixed-methods studies were narratively synthesized and all studies were thematically analyzed. Sixty-eight papers met the eligibility criteria. HCP education on lifestyle management in PCOS was viewed by all to be inadequate, impacting the quality of care and health outcomes. Lifestyle advice delivered by a multidisciplinary team, including dietitians, was identified as a key component for change. All agreed that there was a need for individualized and PCOS-specific lifestyle advice. Weight stigma was identified as negatively impacting both those in larger and smaller bodies with PCOS, reducing the quality of care and affecting self-perception and mental health. People with PCOS perceived that lifestyle management was overly focused on weight loss and fertility, independent of their own personal motivations and goals. Systemic changes, including increasing HCP education on lifestyle management and multidisciplinary collaboration, focusing on lifestyle advice that meets individual needs, and reducing the use of weight-centric care are necessary for long-term sustainable changes and improvements in health outcomes in people with PCOS.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Branched-chain amino acid metabolism: Pathophysiological mechanism and therapeutic intervention in metabolic diseases 支链氨基酸代谢:代谢性疾病的病理生理机制和治疗干预。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-25 DOI: 10.1111/obr.13856
Shama Mansoori, Melody Yuen-man Ho, Kelvin Kwun-wang Ng, Kenneth King-yip Cheng
{"title":"Branched-chain amino acid metabolism: Pathophysiological mechanism and therapeutic intervention in metabolic diseases","authors":"Shama Mansoori,&nbsp;Melody Yuen-man Ho,&nbsp;Kelvin Kwun-wang Ng,&nbsp;Kenneth King-yip Cheng","doi":"10.1111/obr.13856","DOIUrl":"10.1111/obr.13856","url":null,"abstract":"<p>Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential for maintaining physiological functions and metabolic homeostasis. However, chronic elevation of BCAAs causes metabolic diseases such as obesity, type 2 diabetes (T2D), and metabolic-associated fatty liver disease (MAFLD). Adipose tissue, skeletal muscle, and the liver are the three major metabolic tissues not only responsible for controlling glucose, lipid, and energy balance but also for maintaining BCAA homeostasis. Under obese and diabetic conditions, different pathogenic factors like pro-inflammatory cytokines, lipotoxicity, and reduction of adiponectin and peroxisome proliferator-activated receptors γ (PPARγ) disrupt BCAA metabolism, leading to excessive accumulation of BCAAs and their downstream metabolites in metabolic tissues and circulation. Mechanistically, BCAAs and/or their downstream metabolites, such as branched-chain ketoacids (BCKAs) and 3-hydroxyisobutyrate (3-HIB), impair insulin signaling, inhibit adipogenesis, induce inflammatory responses, and cause lipotoxicity in the metabolic tissues, resulting in multiple metabolic disorders. In this review, we summarize the latest studies on the metabolic regulation of BCAA homeostasis by the three major metabolic tissues—adipose tissue, skeletal muscle, and liver—and how dysregulated BCAA metabolism affects glucose, lipid, and energy balance in these active metabolic tissues. We also summarize therapeutic approaches to restore normal BCAA metabolism as a treatment for metabolic diseases.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sharing the motherload: A review and development of the CO–Parent conceptual model for early childhood obesity prevention 分担母亲的负担:儿童早期肥胖预防的 CO-Parent 概念模型回顾与发展。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-17 DOI: 10.1111/obr.13853
Konsita Kuswara, Vanessa A. Shrewsbury, Jacqui A. Macdonald, Alexandra Chung, Briony Hill
{"title":"Sharing the motherload: A review and development of the CO–Parent conceptual model for early childhood obesity prevention","authors":"Konsita Kuswara,&nbsp;Vanessa A. Shrewsbury,&nbsp;Jacqui A. Macdonald,&nbsp;Alexandra Chung,&nbsp;Briony Hill","doi":"10.1111/obr.13853","DOIUrl":"10.1111/obr.13853","url":null,"abstract":"<p>Fathers remain under-represented in early childhood obesity prevention research and interventions, despite growing evidence that paternal biopsychosocial factors and behaviors from pre- and post-conception can influence lifelong offspring health. Informed by a literature review of high-quality evidence, “CO–Parent” (childhood obesity–Parent) is a new conceptual model underpinned by couple interdependence theory and a socioecological framework. Literature was searched for the concepts parental AND weight-related behaviors AND child weight or weight-related behaviors, in databases including MEDLINE, PsycINFO, Global Health, Scopus, and SocINDEX. Prior evidence syntheses were prioritized as source data to inform model development. “CO–Parent” illustrates the interdependent and independent effects of maternal and paternal weight, weight-related behaviors, and well-being, across preconception, pregnancy, postpartum, and the early years on child weight-related behaviors and weight up to age five. The influences of public policy, social, environmental, economic, community, and other complex modifiable mediating factors are included in the model. The “CO–Parent” conceptual model paves the way for a paradigm shift by recognizing fathers as key figures in early childhood obesity prevention initiatives, encouraging them to “share the motherload.” It highlights both the independent and interdependent roles fathers play in the epidemiology of obesity starting from preconception. CO–Parent also provides the foundations necessary to guide future theory and research to be more inclusive of fathers to further understanding of the independent and interdependent influences of parents in early childhood obesity prevention.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Core set of patient-reported outcome measures to measure quality of life in obesity treatment research 在肥胖症治疗研究中,用于衡量生活质量的一套患者报告结果核心指标。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-17 DOI: 10.1111/obr.13849
Phillip J. Dijkhorst, Claire E. E. de Vries, Caroline B. Terwee, Ignace M. C. Janssen, Ronald S. L. Liem, Bart A. van Wagensveld, Johan Ottosson, Bruno Halpern, Stuart W. Flint, Elisabeth F. C. van Rossum, Alend Saadi, Lisa West-Smith, Mary O'Kane, Jason C. G. Halford, Karen D. Coulman, Salman Al-Sabah, John B. Dixon, Wendy A. Brown, Ximena Ramos Salas, Maarten M. Hoogbergen, Sally Abbott, Alyssa J. Budin, Jennifer F. Holland, Lotte Poulsen, Richard Welbourn, Bernardo Rea Ruanova, John M. Morton, Francois Pattou, Erman O. Akpinar, Stephanie Sogg, Jacques M. Himpens, Vanessa Osborne, Natasja Wijling, Laura Divine, Nadya Isack, Susie Birney, J. M. Bernadette Keenan, Joe Nadglowski, Jacqueline Bowman, Ken Clare, Riccardo Meloni, Sandra de Blaeij, Theodore K. Kyle, Melanie Bahlke, Andrew Healing, Ian Patton, Valerie M. Monpellier
{"title":"A Core set of patient-reported outcome measures to measure quality of life in obesity treatment research","authors":"Phillip J. Dijkhorst,&nbsp;Claire E. E. de Vries,&nbsp;Caroline B. Terwee,&nbsp;Ignace M. C. Janssen,&nbsp;Ronald S. L. Liem,&nbsp;Bart A. van Wagensveld,&nbsp;Johan Ottosson,&nbsp;Bruno Halpern,&nbsp;Stuart W. Flint,&nbsp;Elisabeth F. C. van Rossum,&nbsp;Alend Saadi,&nbsp;Lisa West-Smith,&nbsp;Mary O'Kane,&nbsp;Jason C. G. Halford,&nbsp;Karen D. Coulman,&nbsp;Salman Al-Sabah,&nbsp;John B. Dixon,&nbsp;Wendy A. Brown,&nbsp;Ximena Ramos Salas,&nbsp;Maarten M. Hoogbergen,&nbsp;Sally Abbott,&nbsp;Alyssa J. Budin,&nbsp;Jennifer F. Holland,&nbsp;Lotte Poulsen,&nbsp;Richard Welbourn,&nbsp;Bernardo Rea Ruanova,&nbsp;John M. Morton,&nbsp;Francois Pattou,&nbsp;Erman O. Akpinar,&nbsp;Stephanie Sogg,&nbsp;Jacques M. Himpens,&nbsp;Vanessa Osborne,&nbsp;Natasja Wijling,&nbsp;Laura Divine,&nbsp;Nadya Isack,&nbsp;Susie Birney,&nbsp;J. M. Bernadette Keenan,&nbsp;Joe Nadglowski,&nbsp;Jacqueline Bowman,&nbsp;Ken Clare,&nbsp;Riccardo Meloni,&nbsp;Sandra de Blaeij,&nbsp;Theodore K. Kyle,&nbsp;Melanie Bahlke,&nbsp;Andrew Healing,&nbsp;Ian Patton,&nbsp;Valerie M. Monpellier","doi":"10.1111/obr.13849","DOIUrl":"10.1111/obr.13849","url":null,"abstract":"<p>The lack of standardization in patient-reported outcome measures (PROMs) has made measurement and comparison of quality of life (QoL) outcomes in research focused on obesity treatment challenging. This study reports on the results of the second and third global multidisciplinary Standardizing Quality of life measures in Obesity Treatment (S.Q.O.T.) consensus meetings, where a core set of PROMs to measure nine previously selected patient-reported outcomes (PROs) in obesity treatment research was established.</p><p>The S.Q.O.T. II online and S.Q.O.T. III face-to-face hybrid consensus meetings were held in October 2021 and May 2022. The meetings were led by an independent moderator specializing in PRO measurement. Nominal group techniques, Delphi exercises, and anonymous voting were used to select the most suitable PROMs by consensus. The meetings were attended by 28 and 27 participants, respectively, including a geographically diverse selection of people living with obesity (PLWO) and experts from various disciplines.</p><p>Out of 24 PROs and 16 PROMs identified in the first S.Q.O.T. consensus meeting, the following nine PROs and three PROMs were selected via consensus: BODY-Q (physical function, physical symptoms, psychological function, social function, eating behavior, and body image), IWQOL-Lite (self-esteem), and QOLOS (excess skin). No PROM was selected to measure stigma as existing PROMs deemed to be inadequate.</p><p>A core set of PROMs to measure QoL in research focused on obesity treatment has been selected incorporating patients' and experts' opinions. This core set should serve as a minimum to use in obesity research studies and can be combined with clinical parameters.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prognostic role of food addiction for weight loss treatment outcomes in individuals with overweight and obesity: A systematic review and meta-analysis 食物成瘾对超重和肥胖症患者减肥治疗结果的预后作用:系统回顾和荟萃分析。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-16 DOI: 10.1111/obr.13851
Georg Halbeisen, Marie Pahlenkemper, Luisa Sabel, Candice Richardson, Zaida Agüera, Fernando Fernandez-Aranda, Georgios Paslakis
{"title":"The prognostic role of food addiction for weight loss treatment outcomes in individuals with overweight and obesity: A systematic review and meta-analysis","authors":"Georg Halbeisen,&nbsp;Marie Pahlenkemper,&nbsp;Luisa Sabel,&nbsp;Candice Richardson,&nbsp;Zaida Agüera,&nbsp;Fernando Fernandez-Aranda,&nbsp;Georgios Paslakis","doi":"10.1111/obr.13851","DOIUrl":"10.1111/obr.13851","url":null,"abstract":"<p>Food addiction (FA) could be a potential prognostic factor of weight loss intervention outcomes. This systematic review with meta-analysis aimed to (1) estimate this prognostic effect of FA diagnosis and symptom count in individuals with overweight or obesity and (2) explore potential sources of heterogeneity based on properties of the weight loss intervention, study, and sample (e.g., age, gender, ethnicity). We searched PubMed, PsycINFO, and Web of Science for studies reporting on associations between pre-intervention FA (assessed with the Yale Food Addiction Scale) and weight outcomes after weight loss intervention in individuals with overweight or obesity without a medically diagnosed eating disorder. Twenty-five studies met inclusion criteria, including 4904 individuals (71% women, <i>M</i><sub>age</sub> = 41 years, BMI = 40.82 kg/m<sup>2</sup>), <i>k</i> = 18 correlations of weight loss with FA symptom count, and <i>k</i> = 21 mean differences between FA diagnosis groups. Pooled estimates of random-effects meta-analyses found limited support for a detrimental effect of FA symptom count and diagnosis on weight loss intervention outcomes. Negative associations with FA increased for behavioral weight loss interventions and among more ethnically diverse samples. More research on the interaction of FA with pre-existing mental health problems and environmental factors is needed.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causality of visceral adipose tissue on chronic kidney disease and renal function measure indicators, and mediation role of hypertension: Mendelian randomization study 内脏脂肪组织对慢性肾脏病和肾功能测量指标的因果关系及高血压的中介作用:孟德尔随机研究
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-10 DOI: 10.1111/obr.13845
Teng-Yu Gao, Jun-Chi Wang, Qi-Jian Zhao, Xiang-Ning Zhou, Yu-Ting Jiang, Lian Ren, Chao Zhang
{"title":"Causality of visceral adipose tissue on chronic kidney disease and renal function measure indicators, and mediation role of hypertension: Mendelian randomization study","authors":"Teng-Yu Gao,&nbsp;Jun-Chi Wang,&nbsp;Qi-Jian Zhao,&nbsp;Xiang-Ning Zhou,&nbsp;Yu-Ting Jiang,&nbsp;Lian Ren,&nbsp;Chao Zhang","doi":"10.1111/obr.13845","DOIUrl":"10.1111/obr.13845","url":null,"abstract":"<p>Although chronic kidney disease (CKD) is associated with obesity, few studies have used visceral adipose tissue (VAT) as an indicator to investigate its causal effect on CKD. Therefore, Mendelian randomization (MR) was employed to study the causal effects of VAT on CKD and its potential mediation by hypertension. Genome-wide association study (GWAS) statistics on VAT exposure were obtained from the UK Biobank, while GWAS datasets of CKD outcomes were obtained from CKDGen and FinnGen (validation study). Furthermore, VAT was considered the exposure, with the estimated glomerular filtration rate based on creatinine (eGFR (crea)), estimated glomerular filtration rate based on cystatin C (eGFR(cys)), and blood urea nitrogen (BUN) employed to assess the causal effect of VAT on kidney test indicators. Lastly, a two-step MR method was used to study the mediating role of hypertension in the pathogenesis of VAT among patients with CKD. VAT exhibited a positive causal association with CKD, irrespective of whether the GWAS datasets from CKDGen (odds ratio [OR] = 1.18, 95% CI: 1.08 to 1.29, P = 1.433140e−04) or FinnGen (1.47, 1.30 to 1.67, <i>p</i> = 2.500000e−09). VAT was not causally associated with eGFR (crea) (1.00, 0.99 to 1.00, <i>p</i> = 0.53), was negatively associated with eGFR (cys) (0.95, 0.93 to 0.97, P = 5.070000e−10), and was positively associated with BUN (1.02,1.01 to 1.02, P = 7.824860e−04). The mediating effect of VAT on CKD via hypertension was 45.8% (95% CI: 26.4 65.1). VAT has a positive causal effect on CKD, with hypertension playing a significant role. However, the effects of VAT on renal function indicators require further investigation.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weight/height2: Mathematical overview of the world's most widely used adiposity index 体重/身高2:世界上最广泛使用的脂肪指数的数学概述。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-10 DOI: 10.1111/obr.13842
Steven B. Heymsfield, John D. Sorkin, Diana M. Thomas, Shengping Yang, Moonseong Heo, Cassidy McCarthy, Jasmine Brown, Angelo Pietrobelli
{"title":"Weight/height2: Mathematical overview of the world's most widely used adiposity index","authors":"Steven B. Heymsfield,&nbsp;John D. Sorkin,&nbsp;Diana M. Thomas,&nbsp;Shengping Yang,&nbsp;Moonseong Heo,&nbsp;Cassidy McCarthy,&nbsp;Jasmine Brown,&nbsp;Angelo Pietrobelli","doi":"10.1111/obr.13842","DOIUrl":"10.1111/obr.13842","url":null,"abstract":"<p>A footnote in Adolphe Quetelet's classic 1835 Treatise on Man described his algebraic analysis of how body weight (\u0000<span></span><math>\u0000 <mi>W</mi></math>) varies with height (\u0000<span></span><math>\u0000 <mi>H</mi></math>) in adult males and females. Using data on 12 short and 12 tall subjects of each sex, Quetelet established the rule that \u0000<span></span><math>\u0000 <mi>W</mi></math> is approximately proportional (\u0000<span></span><math>\u0000 <mo>∝</mo></math>) to <i>H</i><sup>2</sup> in adults; that is, \u0000<span></span><math>\u0000 <mi>W</mi>\u0000 <mo>∝</mo>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math> when \u0000<span></span><math>\u0000 <mi>W</mi>\u0000 <mo>≈</mo>\u0000 <mi>α</mi>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math> for some constant \u0000<span></span><math>\u0000 <mi>α</mi></math>. Quetelet's Rule (\u0000<span></span><math>\u0000 <mi>W</mi>\u0000 <mo>∝</mo>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math>), transformed and renamed in the twentieth century to body mass index (\u0000<span></span><math>\u0000 <mi>BMI</mi>\u0000 <mo>=</mo>\u0000 <mi>W</mi>\u0000 <mo>/</mo>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math>), is now a globally applied phenotypic descriptor of adiposity at the individual and population level. The journey from footnote to ubiquitous adiposity measure traveled through hundreds of scientific reports and many more lay publications. The recent introduction of highly effective pharmacologic weight loss treatments has heightened scrutiny of BMI's origins and appropriateness as a gateway marker for diagnosing and monitoring people with obesity. This contemporary context prompted the current report that delves into the biological and mathematical paradigms that underlie the simple index \u0000<span></span><math>\u0000 <mi>BMI</mi>\u0000 <mo>=</mo>\u0000 <mi>W</mi>\u0000 <mo>/</mo>\u0000 <msup>\u0000 <mi>H</mi>\u0000 <mn>2</mn>\u0000 </msup></math>. Students and practitioners can improve or gain new insights into their understanding of BMI's historical origins and quantitative underpinning from the provided overview, facilitating informed use of BMI and related indices in research and clinical settings.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on drug repurposing applicable to obesity 回顾适用于肥胖症的药物再利用。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-09 DOI: 10.1111/obr.13848
Feng Chen, Kai Jing, Zhen Zhang, Xia Liu
{"title":"A review on drug repurposing applicable to obesity","authors":"Feng Chen,&nbsp;Kai Jing,&nbsp;Zhen Zhang,&nbsp;Xia Liu","doi":"10.1111/obr.13848","DOIUrl":"10.1111/obr.13848","url":null,"abstract":"<div>\u0000 \u0000 <p>Obesity is a major public health concern and burden on individuals and healthcare systems. Due to the challenges and limitations of lifestyle adjustments, it is advisable to consider pharmacological treatment for people affected by obesity. However, the side effects and limited efficacy of available drugs make the obesity drug market far from sufficient. Drug repurposing involves identifying new applications for existing drugs and offers some advantages over traditional drug development approaches including lower costs and shorter development timelines. This review aims to provide an overview of drug repurposing for anti-obesity medications, including the rationale for repurposing, the challenges and approaches, and the potential drugs that are being investigated for repurposing. Through advanced computational techniques, researchers can unlock the potential of repurposed drugs to tackle the global obesity epidemic. Further research, clinical trials, and collaborative efforts are essential to fully explore and leverage the potential of drug repurposing in the fight against obesity.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Role of telemedicine in the management of obesity: State of the art review” 更正 "远程医疗在肥胖症管理中的作用:最新进展回顾"。
IF 8 2区 医学
Obesity Reviews Pub Date : 2024-10-09 DOI: 10.1111/obr.13846
{"title":"Correction to “Role of telemedicine in the management of obesity: State of the art review”","authors":"","doi":"10.1111/obr.13846","DOIUrl":"10.1111/obr.13846","url":null,"abstract":"<p>\u0000 <span>Shariq, K.</span>, <span>Siddiqi, TJ</span>, <span>Spall, H</span>, et al. <span>Role of telemedicine in the management of obesity: state-of-the-art review</span>. <i>Obes Rev</i>. <span>2024</span>; <span>25</span>(<span>6</span>)e13734. doi:10.1111/obr.13734</p><p>The corresponding author of this article should be Kainat Shariq. Details of the new corresponding author are mentioned below.</p><p>Kainat Shariq, MBBS, Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan. Email: <span>[email protected]</span></p><p>We apologize for this error.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 2","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信