Obesity Reviews最新文献

{"title":"Determinants of adherence to obesity medication: A narrative review","authors":"Arya M. Sharma,&nbsp;Susie Birney,&nbsp;Michael Crotty,&nbsp;Nick Finer,&nbsp;Gabriella Segal-Lieberman,&nbsp;Verónica Vázquez-Velázquez,&nbsp;Bernard Vrijens","doi":"10.1111/obr.13885","DOIUrl":"10.1111/obr.13885","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>The increasing prevalence of obesity, complex nature of this chronic disease, and risks of developing obesity-related comorbidities outline the need for sustainable and effective management for people living with obesity. In addition to behavioral interventions, obesity medications (OMs) are increasingly considered an integral part of management of people living with obesity. OM adherence is essential to achieve the health benefits of these medications. Adherence to medications, defined as the process by which patients take their medications as prescribed, is determined by a range of factors and can be broken down into phases: initiation, implementation, and persistence (the persistence phase includes discontinuation/stopping treatment). Obesity-specific challenges exist to optimize OM adherence, which may explain varying OM adherence compared with medication for other chronic diseases (diabetes, hypertension, dyslipidemia, and osteoporosis). However, lessons can be learned from other chronic diseases to improve OM adherence, for example from type 2 diabetes and hypertension. This review aims to provide practical guidance for identifying OM- and obesity-specific determinants of adherence and discusses adherence determinants per adherence phase and obesity management phase (weight gain, weight loss, and weight stabilization/regain). This practical guidance will assist with developing obesity-specific interventions to improve OM adherence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Practitioner Points</h3>\u0000 \u0000 <div>\u0000 \u0000 <ul>\u0000 \u0000 <li>OMs are increasingly considered as an integral part of obesity management; however, like with all chronic disease medications, low adherence to these medications is often observed, impacting their therapeutic effect.</li>\u0000 \u0000 <li>Adherence to obesity medication can be affected at any phase of obesity management (weight gain, weight loss, and weight stabilization/regain) so considering the disease phase can help identify potential reasons for low adherence.</li>\u0000 \u0000 <li>Future initiatives to improve adherence to obesity medication should be a key focus of discussions at each opportunity with healthcare professionals, including thorough evaluation and targeted education, all in a supportive and stigma-free manner.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 5","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13885","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From preschool to policy: A scoping review of recommended interventions for a systems approach to improve dietary intake in early childhood","authors":"Jacqueline Chan,&nbsp;Patrick Conroy,&nbsp;Philayrath Phongsavan,&nbsp;David Raubenheimer,&nbsp;Margaret Allman-Farinelli","doi":"10.1111/obr.13897","DOIUrl":"10.1111/obr.13897","url":null,"abstract":"<p>Early childhood is a key opportunity to establish healthy eating behaviors and prevent future non-communicable diseases associated with poor diets. How to effectively intervene in the system of the many determinants influencing children's dietary intake remains unclear. This scoping review aimed to map the determinants of nutrition and eating that have been addressed in early childhood nutrition interventions and identify which of these improve dietary intake. We searched six electronic databases to identify eligible studies published from January 2000 to January 2024. We included studies of any interventions reporting dietary intake among children aged between two and five years. A total of 193 eligible studies were identified and mapped to the Determinants of Nutrition and Eating (DONE) Framework. Parent (<i>n</i> = 97) and child (<i>n</i> = 76) food knowledge and skills were most frequently addressed. Most studies addressing parent (67%) and child (66%) food knowledge and skills reported improvements in dietary intake. Government regulations such as healthy food subsidies, and food advertising and labeling interventions showed promised, with 82% of studies reporting improvements in dietary intake. However, these interventions were predominantly implemented in the United States and Chile. This review provides a comprehensive and systematic map of a range of interventions that positively influence nutritional outcomes in preschool-aged children but recommends further policy-level action globally.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 6","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13897","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pollution, stress response, and obesity: A systematic review","authors":"Sandra El Kouche,&nbsp;Sarah Halvick,&nbsp;Chloe Morel,&nbsp;Radu-Corneliu Duca,&nbsp;An van Nieuwenhuyse,&nbsp;Jonathan D. Turner,&nbsp;Nathalie Grova,&nbsp;David Meyre","doi":"10.1111/obr.13895","DOIUrl":"10.1111/obr.13895","url":null,"abstract":"<p>Limited literature addresses the association between pollution, stress, and obesity, and knowledge synthesis on the associations between these three topics has yet to be made. Two reviewers independently conducted a systematic review of MEDLINE, Embase, and Web of Science Core Collection databases to identify studies dealing with the effects of semi-volatile organic compounds, pesticides, conservatives, and heavy metals on the psychosocial stress response and adiposity in humans, animals, and cells. The quality of papers and risk assessment were evaluated with ToxRTool, BEES-C instrument score, SYRCLE's risk of bias tool, and CAMARADES checklist. A protocol for the systematic review was registered on PROSPERO. Of 1869 identified references, 63 were eligible after title and abstract screening, 42 after full-text reading, and risk of bias and quality assessment. An important body of evidence shows a positive association between pollution, stress response, and obesity. Pollution stimulates the hypothalamic–pituitary–adrenal axis by activating the glucocorticoid receptor signaling and transcriptional factors responsible for adipocyte differentiation, hyperphagia, and obesity. Endocrine-disrupting chemicals also alter the Peroxisome Proliferator-activated Receptor gamma pathway to promote adipocyte hyperplasia and hypertrophy. However, these associations depend on sex, age, and pollutant type. Our findings evidence that pollution promotes stress, leading to obesity.</p><p></p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 5","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to and enablers of modifying diet after metabolic bariatric surgery: A systematic review of published literature","authors":"Reyhaneh Yousefi,&nbsp;Simon L. Bacon,&nbsp;Vincent Gosselin Boucher,&nbsp;Patricia F. C. Acosta,&nbsp;John O'Neill,&nbsp;Manuela González-González,&nbsp;Florence Coulombe Raymond,&nbsp;Fabiana Lorencatto","doi":"10.1111/obr.13893","DOIUrl":"10.1111/obr.13893","url":null,"abstract":"<div>\u0000 \u0000 <p>This is a qualitative systematic review in which we investigated barriers and enablers influencing dietary behavior change after metabolic bariatric surgery (MBS). Database searches retrieved publications reporting perceived factors influencing dietary behavior change post-MBS. Data (quotes, survey results, interpretative summaries) were extracted and analyzed using combined deductive and inductive thematic analyses. The generated barrier/enabler themes mapped to the Theoretical Domains Framework and then behavior change techniques to identify potential strategies to improve post-operative dietary behavior. Thirty-four publications were included. Key barriers fell within the domains of ‘Environmental Context and Resources’ (e.g., insufficient and unreliable healthcare services), ‘Behavioral Regulation’ (e.g., lack of self-discipline), ‘Emotions’ (e.g., eating as a strategy to overcome negative emotions), ‘Beliefs about Consequences’ (e.g., the extent of realistic expectations from MBS), and ‘Social Influences’ (e.g., challenge of eating at social events). Key enablers were also identified within ‘Environmental Context and Resources’ (e.g. self-access internet-based resources), ‘Behavioral Regulation’ (e.g. learning how to develop new dietary strategies), ‘Beliefs about Consequences’ (e.g., positive impacts of surgery-induced food intolerances), and ‘Social Influences’ (e.g., support from social/group sessions). Potential strategies to change postoperative dietary behavior include <i>social support, problem-solving, goal setting, and self-monitoring of behavior</i>. This provides insight into the targets for future post-operative nutrition-focused interventions.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 6","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migrant parents' perceptions of the benefits, barriers, and facilitators of young children's physical activity and sedentary behavior: A systematic review of qualitative studies","authors":"Susan Paudel,&nbsp;Sarah Marshall,&nbsp;Jenny Veitch,&nbsp;Chahana Paudel,&nbsp;Kylie D. Hesketh","doi":"10.1111/obr.13889","DOIUrl":"10.1111/obr.13889","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Despite increasing global migration, children from migrant backgrounds are underrepresented in physical activity research. This systematic review aimed to consolidate existing qualitative evidence on parental perceptions of the benefits, barriers, and facilitators of promoting physical activity and limiting sedentary behavior of their first- or second-generation migrant children aged 0–6 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Six electronic databases (Medline, CINAHL, PsycINFO, SPORTDiscus, Global, and Health EMBASE) were searched for qualitative peer-reviewed English language studies using terms covering migrants, parents, perceptions, physical activity, and sedentary behavior. Analysis was guided by the best-fit framework synthesis approach and the socio-ecological model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Database searches yielded 6059 unique records, with 33 studies included in this review. Key parent perceived benefits of physical activity were better health outcomes, development, and long-term outcomes and perceived benefits of sedentary behavior were education, health and development, and a parenting tool to keep children calm and occupied. Eight themes (25 sub-themes) across four levels of the socio-ecological model (primarily interpersonal and community level) were identified as barriers and facilitators of physical activity. Seven themes (14 sub-themes: primarily interpersonal) were identified for sedentary behavior.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Parents from migrant backgrounds perceived that their young children experienced some unique barriers to physical activity and sedentary behavior.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 5","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13889","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of eHealth interventions to promote physical activity in young, middle-aged, and late middle-aged adults with obesity or overweight","authors":"Seungmin Lee,&nbsp;Soyeon Ahn,&nbsp;Priya Patel,&nbsp;Nicholas D. Myers","doi":"10.1111/obr.13898","DOIUrl":"10.1111/obr.13898","url":null,"abstract":"<p>The purpose of this study was to calculate the effects of recent eHealth interventions to promote physical activity in young, middle-aged, and late middle-aged adults with obesity or overweight. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. In the search, 3550 articles were identified, and 15 studies met all inclusion criteria. The effects of recent eHealth interventions depended on the type of outcome variable: (a) intensity-based physical activity (e.g., moderate-to-vigorous-intensity physical activity, average minutes per day from intensity categories, steps per day) or (b) energy expenditure-based physical activity (e.g., metabolic equivalent of task, kilocalories per week). The overall effects of recent eHealth interventions on the physical activity outcomes in adults with obesity were positive and ranged from small to medium in size. Ethnicity and weight status moderated the effects of recent eHealth interventions on physical activity outcomes. Results from this meta-analysis provided some evidence for both the utility of, and possible improvements to, eHealth interventions to promote health-enhancing physical activity in at-risk populations.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 6","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13898","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulated retail food environments: A literature review of systems science approaches to advance equity in access to healthy diets","authors":"Yeeli Mui,&nbsp;Megan R. Winkler,&nbsp;Shanda L. Hunt,&nbsp;Joel Gittelsohn,&nbsp;Melissa Tracy","doi":"10.1111/obr.13887","DOIUrl":"10.1111/obr.13887","url":null,"abstract":"<p>As researchers increasingly utilize systems science simulation modeling (SSSM), little is known about how and by whom SSSMs are being leveraged to address inequities in access to healthy diets. We evaluated the extent to which studies (<i>n</i> = 66) employing SSSM to examine retail food environments (RFEs): included three pillars of equity (<i>social position, human capital, socioeconomic and political context</i>) that shape RFEs and access to healthy diets; grounded model design and development in theory; engaged with diverse stakeholders and lived experiences related to RFEs; and translated model findings towards addressing inequities in RFEs. Most studies (<i>n</i> = 58) included some model characteristics related to <i>social position</i> (e.g., age). Characteristics related to <i>human capital</i> (e.g., meal planning skills) were the least integrated fundamental pillar (<i>n</i> = 15). All studies included some characteristics related to <i>socioeconomic and political context</i>; however, we found little to no incorporation of social contexts (e.g., cultural and societal norms). Regarding model design and development, less than one-third of studies specified theoretical frameworks or engaged with local domain experts and stakeholders. While certain research objectives and, consequently, model types lend themselves better than others to address key pillars that influence RFEs, findings show that models are not fully leveraging SSSMs to analyze the multiple, interacting dimensions – particularly social phenomena – influencing equity in access to healthy diets. Greater attention to engaging stakeholders and the role of human capital and social contexts will likely better equip models to more holistically examine equitable food access, including essential pathways and unintended consequences of programs and policies.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 5","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity","authors":"Mikołaj Domagalski,&nbsp;Joanna Olszańska,&nbsp;Katarzyna Pietraszek-Gremplewicz,&nbsp;Dorota Nowak","doi":"10.1111/obr.13873","DOIUrl":"https://doi.org/10.1111/obr.13873","url":null,"abstract":"<p>Colorectal cancer (CRC) is the third most common cancer worldwide and has one of the highest mortality rates. Considering its nonlinear etiology, many risk factors are associated with CRC formation and development, with obesity at the forefront. Obesity is regarded as one of the key environmental risk determinants for the pathogenesis of CRC. Excessive food intake and a sedentary lifestyle, together with genetic predispositions, lead to the overgrowth of adipose tissue along with a disruption in the number and function of its building cells. Adipose tissue-resident cells may constitute part of the CRC microenvironment. Alterations in their physiology and secretory profiles observed in obesity may further contribute to CRC progression, and despite similar localization, their contributions are not equivalent. They can interact with CRC cells, either directly or indirectly, influencing various processes that contribute to tumorigenesis. The main aim of this review is to provide insights into the diversity of adipose tissue resident cells, namely, adipocytes, adipose stromal cells, and immunological cells, regarding the role of particular cell types in co-forming the CRC microenvironment. The scope of this study was also devoted to the abnormalities in adipose tissue physiology observed in obesity states and their impact on CRC development.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 4","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13873","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143564885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of evidence that environmental contaminant exposure impedes weight loss and glycemic control during calorie-restricted diets in humans","authors":"Kimberley Ann Bennett,&nbsp;Calum Sutherland,&nbsp;Anne Louise Savage","doi":"10.1111/obr.13886","DOIUrl":"10.1111/obr.13886","url":null,"abstract":"<p>Calorie-restricted diets cause weight loss and can drive type 2 diabetes remission. However, many patients struggle to achieve clinically relevant weight loss, and the reasons are not well understood. Chemical exposure is associated with obesity and type 2 diabetes development, and some evidence from preclinical experiments suggests it can limit the clinical benefits of calorie restriction. We systematically reviewed the evidence for the effects of environmental chemical exposure on mass loss and glycemic control during diet-induced weight management in humans (PROSPERO: CRD42022339993). Of 222 unique citations, only six papers directly examined this question. Only one targeted people with type 2 diabetes. One linked phthalates and parabens, but not bisphenols, with slower fat loss. Two showed per- and polyfluoroalkyl substances were not associated with mass loss, but with faster subsequent mass regain. One linked impaired adiposity improvements with air pollutants. Two papers reported weight loss-induced elevation in plasma organochlorines associated with altered glycemic control. The risk of bias largely arose from the potential for deviation from the intended diet, and statistics and reporting. The role of chemical exposure in impeding the effectiveness of weight management programs needs to be better understood to provide suitable support to people living with obesity and type 2 diabetes.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 5","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis assessing reliability of the Yale Food Addiction Scale: Implications for compulsive eating and obesity","authors":"Haitham Jahrami,&nbsp;Waqar Husain,&nbsp;Khaled Trabelsi,&nbsp;Achraf Ammar,&nbsp;Seithikurippu R. Pandi-Perumal,&nbsp;Zahra Saif,&nbsp;Marc N. Potenza,&nbsp;Chung-Ying Lin,&nbsp;Amir H. Pakpour","doi":"10.1111/obr.13881","DOIUrl":"10.1111/obr.13881","url":null,"abstract":"<p>Food addiction (FA) is linked to eating disorders and obesity. The Yale Food Addiction Scale (YFAS), which has various versions in different languages, is widely used to assess FA worldwide. This meta-analysis aimed to assess the YFAS through reliability generalization meta-analysis (REGEMA). From their inception until April 2024, a comprehensive systematic review across more than 30 databases was conducted to identify studies reporting reliability measures (e.g., Cronbach's alpha and McDonald's omega) of the YFAS. Sixty-five studies were included in this meta-analysis, with a median sample size of 451 participants. The results of the random-effects meta-analysis showed a high pooled reliability coefficient (<i>α</i> = 0.85, 95% CI: 0.83 to 0.86 <i>p</i> &lt; 0.001). Test–retest reliability was also estimated using a random-effects meta-analysis of 10 studies, resulting in a pooled test–retest correlation coefficient of intraclass coefficients of (<i>ICC</i> = 0.77, 95% CI: 0.70 to 0.84, <i>p</i> &lt; 0.001). These findings highlight the consistency and robustness of the YFAS in detecting FA across studies, suggesting its reliability for screening for FA-related disordered eating.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 4","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13881","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}