Obesity Reviews最新文献

{"title":"Neutrophils as indicators of obesity-associated inflammation: A systematic review and meta-analysis","authors":"Gema Gomez-Casado,&nbsp;Andres Jimenez-Gonzalez,&nbsp;Alba Rodriguez-Muñoz,&nbsp;Francisco J. Tinahones,&nbsp;Ernesto González-Mesa,&nbsp;Mora Murri,&nbsp;Almudena Ortega-Gomez","doi":"10.1111/obr.13868","DOIUrl":"10.1111/obr.13868","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The aim of this study is to evaluate and compare the suitability of routine blood neutrophil values as indicators of obesity-associated inflammation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this systematic review and meta-analysis, we assess absolute neutrophil counts (ANCs) and neutrophil-to-lymphocyte ratio (NLR) values in subjects with and without obesity and analyze the weight of both parameters on the disease. Additionally, correlation studies between ANC and NLR with BMI, a parameter internationally accepted to define obesity are performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Quantitative data from 12 (ANC) and 11 (NLR) studies were included, with a total of 4475 participants. The meta-analysis shows that while both parameters are increased in the obesity group, ANC values present higher differences with the control and less heterogeneity among studies. Additionally, unlike NLR, ANC demonstrates a positive and significant correlation with BMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, this meta-analysis demonstrates that ANC is a more reliable and stable parameter than NLR for the assessment of obesity-related inflammation, which offers clinicians a novel tool to assist in preventing complications related to obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review: The gut microbiota as a link between colorectal cancer and obesity","authors":"Antonio Jesús Ruiz-Malagón,&nbsp;María Jesús Rodríguez-Sojo,&nbsp;Eduardo Redondo,&nbsp;María Elena Rodríguez-Cabezas,&nbsp;Julio Gálvez,&nbsp;Alba Rodríguez-Nogales","doi":"10.1111/obr.13872","DOIUrl":"10.1111/obr.13872","url":null,"abstract":"<p>Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and progression of colorectal cancer (CRC), as well as its response to different systemic therapies. Likewise, obesity, one of the most important risk factors for CRC, is also well known for its association with gut dysbiosis. Moreover, obesity and CRC display, apart from microbial dysbiosis, chronic inflammation, which participates in their pathogenesis. Although human and murine studies demonstrate the significant impact of the microbiome in regulating energy metabolism and CRC development, little is understood about the contribution of the microbiome to the development of obesity-associated CRC. Therefore, this systematic review explores the evidence for microbiome changes associated with these conditions and hypothesizes that this may contribute to the pathogenesis of obesity-related CRC. Two databases were searched, and different studies on the relationship among obesity, intestinal microbiota and CRC in clinical and preclinical models were selected. Data extraction was carried out by two reviewers independently, and 101 studies were finally considered. Findings indicate the existence of a risk association between obesity and CRC derived from metabolic, immune, and microbial disorders.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 4","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13872","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbrella review of systematic reviews to inform the development and translation of community-based childhood obesity prevention interventions","authors":"Jane Jacobs,&nbsp;Luke Wolfenden,&nbsp;Kristy A. Bolton,&nbsp;Vicki Brown,&nbsp;Marufa Sultana,&nbsp;Kathryn Backholer,&nbsp;Steven Allender,&nbsp;Rachel Novotny,&nbsp;Anna Peeters,&nbsp;Melanie Nichols","doi":"10.1111/obr.13864","DOIUrl":"10.1111/obr.13864","url":null,"abstract":"<p>Community-based interventions (CBIs) can be effective and feasible for the prevention of childhood obesity. The aim of this umbrella review is to determine if systematic reviews report sufficient information to guide replication or adaptation of CBIs to a variety of contexts and aid in further development of childhood obesity prevention CBIs. Six databases were searched for systematic reviews including obesity prevention CBIs involving 0–18 year olds and reporting weight-related outcomes. Two researchers screened results. Evidence-to-decision frameworks guided which details may be required for decision-makers to design and carry-out a CBI, including information on intervention characteristics, outcome reporting and translation factors. From 3935 search results, 40 studies were included. The most frequently reported relevant pieces of information were behaviors targeted (100% of systematic reviews), intervention duration (90%) and settings involved (97.5%). Less frequently reported factors included specific actions implemented (48%), intervention intensity (30%) and organizations, or contributors involved (40%). There was a low level of reporting of equity considerations (27.5%), adverse events (20%), and costs/cost-effectiveness (17.5%). Multilevel interventions for child obesity prevention have demonstrated effectiveness, yet additional documentation of successful intervention processes is needed.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13864","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of behavioral weight management interventions on eating behavior traits in adults with overweight or obesity: A systematic review and meta-analysis","authors":"Laura Kudlek,&nbsp;Patricia Eustachio Colombo,&nbsp;Amy Ahern,&nbsp;Struan Tait,&nbsp;Natasha Reid,&nbsp;Milindu Wickramarachchi,&nbsp;Aiswarya Lakshmi,&nbsp;Stephen J. Sharp,&nbsp;Marie Spreckley,&nbsp;Julia Mueller,&nbsp;Rebecca A. Jones","doi":"10.1111/obr.13871","DOIUrl":"10.1111/obr.13871","url":null,"abstract":"<p>Eating behavior traits (EBTs), defined as personal tendencies determining food intake, can be useful targets for behavioral weight management interventions. Previous reviews have examined the impact of specific intervention types on EBTs, not reflecting the breadth of interventions used in practice. This systematic review and meta-analysis synthesized evidence on the impact of all types of behavioral weight management interventions on EBTs. We searched seven databases and included randomized controlled trials reporting EBT outcomes following behavioral weight management interventions delivered to adults with overweight or obesity. Using random-effects meta-analyses, we synthesized findings from 27 trials at the end of intervention and 12 months (±3 months) post intervention. We found evidence to suggest that interventions improved uncontrolled eating, external eating, susceptibility to hunger, restraint and intuitive eating at intervention end when compared with waitlist, minimal or usual care control. We found no evidence of effects on emotional eating, disinhibition, and hedonic hunger. At follow-up, effects on restraint remained, but we found no evidence of an effect on emotional eating, hedonic hunger and uncontrolled eating. Findings were limited by low numbers of contributing trials. More high-quality trials reporting EBTs are needed to better understand the impact of adult behavioral weight management interventions on EBTs.</p><p><b>PROSPERO registration number:</b> CRD42022367505.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 4","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13871","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of childhood obesity with pubertal development in boys: A systematic review and meta-analysis","authors":"Jia-Shuan Huang,&nbsp;Chang Gao,&nbsp;Wan-Qing Xiao,&nbsp;Xuan-Yu Zhang,&nbsp;Xiao-Wen Zhong,&nbsp;Yi-Qi Qin,&nbsp;Min-Shan Lu,&nbsp;Cheng-Hao Zhang,&nbsp;Kun Yang,&nbsp;Jia-Min Liang,&nbsp;Chi Chiu Wang,&nbsp;Ronald Ching Wan Ma,&nbsp;Jian-Rong He,&nbsp;Xiu Qiu","doi":"10.1111/obr.13869","DOIUrl":"10.1111/obr.13869","url":null,"abstract":"<div>\u0000 \u0000 <p>Childhood obesity leads to early puberty development in girls, but its effect in boys remains unclear. We conducted a systematic review and meta-analysis to study the association between childhood obesity and puberty development in boys. We included 14 cohort studies with 114,822 boys. Meta-analysis showed that childhood overweight (RR, 1.44; 95%CI, 1.08–1.93; the number of studies [<i>N</i>] = 4) and obesity (RR, 1.35; 95%CI, 1.11–1.64; <i>N</i> = 5) were associated with the earlier occurrence of testicular volume ≥4 mL (Tanner stage 2). Age reaching Tanner stage 2 in overweight boys was earlier than normal-weight boys (mean difference: −0.23 years, 95% CI: −0.37 to −0.08; <i>N</i> = 2); a similar trend was observed in obese boys, but the effect estimate did not reach significance level (mean difference: −0.27 years, 95% CI: −0.59 to 0.05; <i>N</i> = 3). Similarly, the age at pubarche in boys with overweight/obesity was earlier than those with normal weight. Qualitative analysis shows first nocturnal emission; change in voice and peak height velocity in boys with overweight/obesity appeared to develop earlier than those with normal weight. These findings suggest overweight/obesity is associated with earlier pubertal development in boys. Due to the limited number of studies identified in this review, further studies are warranted to confirm these associations.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in adherence to physical activity guidelines from 1997 to 2018 among adults with obesity: An analysis from the US National Health Interview Survey","authors":"José Francisco López-Gil,&nbsp;Joaquín Calatayud,&nbsp;Rubén López-Bueno","doi":"10.1111/obr.13866","DOIUrl":"10.1111/obr.13866","url":null,"abstract":"<p>The aim of this study was to estimate the temporal trends in adherence rates to the physical activity (PA) guidelines for aerobic and muscle-strengthening activities (MSA) among United States (US) adults with obesity. We retrieved data from 22 consecutive rounds of the National Health Interview Survey (NHIS) conducted between 1997 and 2018. Meeting with the PA guidelines recommended by the World Health Organization was determined as follows: individuals achieving ≥150 weekly minutes of moderate physical activity (MPA), ≥75 weekly minutes of vigorous physical activity (VPA), and ≥2 weekly MSA training sessions. The prevalence of meeting PA guidelines increased from 9.4% in 1997 to 15.0% in 2018, although less than 2 in 10 adults with obesity met the guidelines throughout the study period. Overall, compared to females, males with obesity were more likely to adhere to PA recommendations (odds ratio (OR) = 2.03 [95% confidence interval (CI), 1.94 to 2.12]). Also, each age year significantly reduced the odds of adhering to PA recommendations overall (OR = 0.97 [95% CI, 0.97 to 0.98]). Compared with their White counterparts, Black and other races people with obesity have higher significant odds of adhering to PA recommendations with, respectively, OR = 1.18 (95% CI, 1.12 to 1.24) and OR = 1.30 (95% CI, 1.18 to 1.43). In representative samples of adults with obesity from the US, there was an increasing trend for meeting PA guidelines, although only less than 2 in 10 met them.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13866","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of laparoscopic bariatric surgery in patients of 70 years and older: A systematic review and meta-analysis","authors":"Jan Kapała,&nbsp;Tomasz Maroszczuk,&nbsp;Natalia Dowgiałło-Gornowicz","doi":"10.1111/obr.13867","DOIUrl":"10.1111/obr.13867","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Aging population and growing obesity prevalence are two major public health issues. Bariatric surgery has been shown to be both safe and effective, but its role in the treatment of the elderly remains controversial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of laparoscopic bariatric surgery in patients over 70 years of age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review and assessment of the literature was performed in November–December 2023. Inclusion criteria gathered studies of elderly (age ≥70 years old) who underwent laparoscopic bariatric surgery. The data extraction focused on weight loss, obesity-related diseases, and complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fourteen retrospective studies were included, involving 3923 septuagenarians (female, 69.70%). One year after the surgery, the mean excess weight loss was 54.66%. At last follow-up, the improvement in obesity-related diseases was regarded as 50% diagnosed with diabetes, 36% with hypertension, 50% with reflux, 36% with sleep apnea, and 25% with hyperlipidemia. The overall postoperative major morbidity and mortality were about 2% and 1%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This systematic review suggests that laparoscopic bariatric surgery is an effective and safe treatment for patients over 70 years of age.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13867","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valuing behavioral interventions for obesity reduction: A scoping review of economic models","authors":"Joanna McLaughlin,&nbsp;Carlos Sillero-Rejon,&nbsp;Theresa H. M. Moore,&nbsp;Hugh McLeod","doi":"10.1111/obr.13865","DOIUrl":"10.1111/obr.13865","url":null,"abstract":"<p>Policymakers require health economic modeling to guide their decision-making over the choice of interventions for obesity. This scoping review was undertaken to report on the health economic models in use for estimating the value of behavioral interventions (individual or population level) for obesity reduction. Electronic databases (MEDLINE, Embase, PsycINFO, EconLit, and Web of Science) were searched for publications meeting inclusion criteria from January 2015 to May 2023. Seventy-three studies were included, using 44 health economic models between them. When considered against the expert recommendations for modeling of this type, only four models (9%) met all five key elements. The element most commonly unfulfilled was the use of a microsimulation modeling approach (41%, <i>n</i> = 18), followed by model validation (46%, <i>n</i> = 20). A majority of models met each of the other elements: use of a lifetime horizon (59%, <i>n</i> = 26), inclusion of key health events (66%, <i>n</i> = 29), and a risk equation approach to event simulation (71%, <i>n</i> = 31). In addition, under half of the studies considered health inequalities in their reporting. Continued proliferation of models with inadequate time horizons, breadth of obesity-related health conditions, and perspectives on costs and outcomes risks underestimation of the benefits of longer term interventions and impacts on health inequalities.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13865","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating metabolic dysfunction-associated steatohepatitis: The fat-trimming FGF21 approach","authors":"Xiaokun Li,&nbsp;Zhiheng Rao,&nbsp;Wenhao Hu,&nbsp;Weiqin Lu,&nbsp;Yongde Luo","doi":"10.1111/obr.13861","DOIUrl":"10.1111/obr.13861","url":null,"abstract":"<div>\u0000 \u0000 <p>Metabolic dysfunction-associated steatohepatitis (MASH) is a condition characterized by hepatosteatosis, inflammation, and tissue damage, with steatosis as the initial stage, which involves chronic, excess deposition of lipids in hepatic lipid droplets. Despite the growing prevalence and serious risks it poses, including liver decompensation, the need for transplantation, and increased patient mortality, MASH currently faces no approved pharmacotherapy. Several promising treatment candidates have emerged from recent clinical trials, including analogs of FGF21 and agonists of the associated FGFR1-KLB complex. These agents were well-tolerated in trials and have demonstrated significant improvements in both histological and biochemical markers of liver fat content, inflammation, injury, and fibrosis in patients with MASH. Endocrine FGF21 plays a vital role in maintaining homeostasis of lipid, glucose, and energy metabolism. It achieves this through pathways that target lipids or lipid droplets in adipocytes and hepatocytes. Mechanistically, pharmacological FGF21 acts as a potent catabolic factor to promote lipid or lipid droplet lipolysis, fatty acid oxidation, mitochondrial catabolic flux, and heat-dissipating energy expenditure, leading to effective clearance of hepatic and systemic gluco-lipotoxicity and inflammatory stress, thereby preventing obesity, diabetes, and MASH pathologies. In this review, we aim to provide an update on the outcomes of clinical trials for several FGF21 mimetics. We compare these outcomes with preclinical studies and offer a lipid-centric perspective on the mechanisms underlying the clinical benefits of these agents for MASH.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommender systems use in weight management mHealth interventions: A scoping review","authors":"Bianca A. de Castro,&nbsp;Sara M. Levens,&nbsp;Margaret Sullivan,&nbsp;George Shaw Jr.","doi":"10.1111/obr.13863","DOIUrl":"10.1111/obr.13863","url":null,"abstract":"<p>The use of recommender systems in mobile health apps for weight control has grown, but user app uptake and engagement remain limited. The objective of our scoping review was to explore the influence of recommender systems on mHealth app user engagement, identify the theoretical frameworks that have been applied on digital health interventions designed for weight management, and examine the key aspects that support tailoring user engagement through recommender systems. Based on existing literature, we identified 13 articles on recommender systems for weight management. Themes emerged, including theoretical underpinnings, authors' domain knowledge, user motivation, and design. Most studies used constructs from the social cognitive theory. We found inconsistencies between authors' domain knowledge and the intervention's content, with few professionals from the health and psychology fields. Only 46% of articles measured user engagement, whereas gamification and tailored messages were common app features. Despite some positive weight change results, more attention is needed toward implementing behavior theory and other strategies to promote app user engagement. Future studies should more accurately measure user motivation and identify the best features and behavioral constructs to increase app user interaction. Larger studies with a more diverse population are needed to generalize findings and evaluate weight loss maintenance and physical activity habits among users of recommender system.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13863","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}