Obesity Reviews最新文献

{"title":"Psychiatric and Cognitive Functioning After Metabolic and Bariatric Surgery: A Systematic Review and Meta-Analysis","authors":"Emma A. van Reekum,&nbsp;Michael Darcy,&nbsp;Jaslyn Drage,&nbsp;Joshua Xu,&nbsp;Kimberly Ng,&nbsp;Benjamin Forestell,&nbsp;Nancy Santesso,&nbsp;Raed A. Joundi,&nbsp;Jorge Wong,&nbsp;Aristithes Doumouras,&nbsp;Valerie H. Taylor,&nbsp;Salim Yusuf,&nbsp;Ryan Van Lieshout","doi":"10.1111/obr.13968","DOIUrl":"10.1111/obr.13968","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To systematically review and meta-analyze psychiatric and cognitive outcomes following metabolic and bariatric surgery (MBS). [Correction added on 1 July 2025, after first online publication: The objective statement has been updated for clarity.]</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Six databases were searched. Randomized controlled trials (RCTs) and nonrandomized studies (NRS) of people with obesity comparing MBS with any nonsurgical intervention or control condition were included. Main outcomes included symptoms of depression, anxiety, and non-normative eating, substance use disorder diagnosis, suicide death, and cognitive performance in attention, memory, and executive function. Evidence certainty was assessed with GRADE. Heterogeneity was explored with subgroup analyses of ≤ 2 years vs. &gt; 2 years post-intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 79 studies (75 NRS and 4 RCTs) found, including 732,149 people with obesity who underwent MBS, and 7,670,770 who did not. Among RCTs, MBS may improve depressive symptoms (standardized mean difference [SMD] = −0.40, 95% CI −1.04, 0.24; very low certainty). Among NRS, there was low to very low certainty that MBS may improve depressive (SMD = 0.56, 95% CI −0.87, −0.26), anxiety (SMD = −0.60, 95% CI −1.00, −0.19), and non-normative eating symptoms (SMD = −0.75, 95% CI −0.97, −0.53) and cognitive performance in attention (SMD = −0.72, 95% CI −1.61, 0.17), but not executive function or memory. MBS may slightly increase suicide deaths (1/1000 more people, 95% CI 0 fewer to 3 more; very low certainty) and substance use disorders (4/100 more, 95% CI from 1 to 9 more; low certainty) &gt; 2-years post-surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Compared to nonsurgical conditions, MBS may improve depression, anxiety, non-normative eating, and attention, but slightly increase suicides and substance use disorders. There was low to very low certainty in most outcomes, therefore additionalhigh-quality studies are needed to strengthen the evidence base.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 11","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?","authors":"Laurent Turner,&nbsp;Anjalee I. Wanasinghe,&nbsp;Pamela Brunori,&nbsp;Sylvia Santosa","doi":"10.1111/obr.13956","DOIUrl":"10.1111/obr.13956","url":null,"abstract":"<p>In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low-grade inflammation. Indeed, adipose tissue inflammation, which partially stems from macrophage infiltration and expression of macrophage-derived cytokines, has local and systemic consequences on health and increases the likelihood of developing obesity-associated comorbidities. In addition, cellular changes driven by macrophages may also further aggravate both adipose tissue dysfunction and inflammation, thus contributing to the onset and progression of several comorbidities including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease, osteoarthritis, some cancers, and dementia. The purpose of this review is to discuss how adipose tissue inflammation relates and contributes to the pathogenesis of obesity-associated comorbidities.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 11","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13956","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histidine-Containing Dipeptides in Obesity and Cardiometabolic Health: A Systematic Scoping Review","authors":"Saeede Saadati,&nbsp;Robel Hussen Kabthymer,&nbsp;Giancarlo Aldini,&nbsp;Thilini R. Thrimawithana,&nbsp;Julie E. Stevens,&nbsp;Kathy Ngyuen,&nbsp;Arshad Majid,&nbsp;Simon M. Bell,&nbsp;Jack Feehan,&nbsp;Aya Mousa,&nbsp;Barbora de Courten","doi":"10.1111/obr.13965","DOIUrl":"10.1111/obr.13965","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Histidine-containing dipeptides (HCDs) have been reported to have anti-inflammatory and antidiabetic properties. Yet, no previous reviews have examined the impact of HCDs on Type 2 diabetes (T2D) risk factors (e.g., obesity) and progression (e.g., microvascular and macrovascular complications). In this scoping review, we aimed to thoroughly examine the evidence on the effects of HCDs, particularly carnosine, which is the most studied HCD, on T2D risk factors and complications and the underlying mechanisms of action.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We systematically searched Ovid-Medline, Embase, CINAHL, Scopus, Web of Science, and Cochrane Library from inception to December 2023. We included experimental studies (animal models and cell studies), observational studies, and randomized controlled trials (RCTs) investigating the mechanism of action of HCDs and the effects of supplementation in individuals with obesity and/or T2D.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The primary literature search yielded 10,973 articles and 121 studies were eligible for inclusion. HCDs have been shown to mitigate inflammation and improve lipid profile and glycemic control in obesity and T2D with or without microvascular and macrovascular complications. However, most studies are experimental, focusing on elucidating the potential mechanisms of action of HCDs, with limited observational data or RCTs of individuals with obesity and/or T2D. No RCTs have investigated the effects of HCDs in individuals with neuropathy, retinopathy, cerebrovascular disease, and cardiovascular disease within a diabetic context.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although the existing evidence, predominantly from preclinical studies, generally supports the use of HCDs for improving cardiometabolic health, further human studies, especially RCTs with adequately powered sample sizes, are needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 11","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13965","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex Interplay Between Obesity and BRCA1/2-Associated Breast Cancer: An Overview.","authors":"Cinzia Giordano, Marianna Puzzo, Rocco Malivindi, Debora Cristofaro, Luca Gelsomino, Daniela Bonofiglio, Carlo Capalbo, Sebastiano Andò, Ines Barone, Stefania Catalano","doi":"10.1111/obr.13969","DOIUrl":"https://doi.org/10.1111/obr.13969","url":null,"abstract":"<p><p>The steadily increasing prevalence of obesity and its association with a growing number of malignancies, including breast cancer, has made this disease spectrum an urgent and critical public health priority, demanding immediate attention and comprehensive action. To date, a growing body of research has been dedicated to the study of obesity/breast cancer biological link, with the most well-documented mechanisms involving chronic inflammation, altered adipokine levels, dysregulated hormone signaling, and insulin/growth factor pathways. Despite significant progress, a substantial gap persists in our present comprehension of the association between adiposity and breast cancer biology in individuals with mutations in the BRCA1/2 genes, the most widely known high-penetrance genes involved in severe breast cancer risk. In this review, we first give an overview of the contribution of BRCA1/2 gene mutations in breast cancer development. Then, we discuss the emerging mechanistic evidence linking obesity with breast cancer, highlighting the impact of metabolic and hormonal factors in BRCA mutation carriers. Insights into the cross-talk between obesity and breast cancer development in BRCA mutation carriers may pave the way to improve proper personalized clinical management of BRCA1/2-associated breast cancer.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13969"},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Street Food Availability on Nutritional Intake and Diet-Related Health Outcomes: A Systematic Review","authors":"Jose-Benito Rosales Chavez,&nbsp;Mariana Romo-Avila,&nbsp;Luis Ortiz-Hernandez","doi":"10.1111/obr.13964","DOIUrl":"10.1111/obr.13964","url":null,"abstract":"<p>The community food environment influences access to food, which depends on the type of food venues available. However, studies predominantly focus on the Global North, often neglecting culturally relevant food sources in the Global South, like street food (SF) stalls. SF are a popular, affordable, and convenient source of energy and nutrients, but research mainly addresses food safety rather than their impact on diet-related non-communicable diseases. This systematic review evaluates SF's roles in food, energy, and nutrient consumption and health outcomes globally. Our team reviewed peer-reviewed articles from eight databases in English, Spanish, and Portuguese, using combinations of key terms related to SF, nutrition, and body weight. A total of 129 articles met the criteria. Findings indicate SF include different items of varied food groups, nutritional contents, and processing extents. SF are vital for providing food access, especially in urban areas near worksites and schools. However, only seven studies explored the link between SF consumption and cardiometabolic risk, showing mixed results. Future research with longitudinal design is necessary for establishing clearer health-impact relationships.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 11","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Leptin Is a Potential Biomarker of Childhood Obesity and an Indicator of the Effectiveness of Weight-Loss Interventions\".","authors":"","doi":"10.1111/obr.13972","DOIUrl":"https://doi.org/10.1111/obr.13972","url":null,"abstract":"","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13972"},"PeriodicalIF":8.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Loop Diagrams of Food Systems, Diet, and Obesity: A Scoping Review of Methods, Contextual Factors, and Outcomes","authors":"Ivana Stankov,&nbsp;Andres Useche,&nbsp;Peter Lekkas,&nbsp;Rosie Mae Henson,&nbsp;Irene Headen,&nbsp;Jonathan Purtle,&nbsp;Brent A. Langellier","doi":"10.1111/obr.13966","DOIUrl":"10.1111/obr.13966","url":null,"abstract":"<p>This scoping review characterizes the literature on qualitative systems methodologies that guide interest-holders in developing causal loop diagrams focused on food systems, diet, and obesity. Peer-reviewed research using interest-holder–driven causal loop diagrams to examine food environments, access, purchasing, diet, obesity, and related interventions/policies was included. A comprehensive search of six databases (ProQuest Central, Scopus, Web of Science, Ovid MEDLINE, Embase, and Emcare) yielded 40 eligible studies from a pool of 1370 unique records. We synthesize study characteristics, the intended uses of causal loop diagrams, methodological approaches, evaluation processes, and key findings. While all studies identified individual and behavioral drivers of obesity, studies based in the Global South more frequently featured structural factors such as racism, discrimination, crime, and incarceration. Papers focused on engaging minoritized populations similarly emphasized structural-level themes such as urban agriculture, gentrification, community investment, and capacity building. Our findings highlight the potential of causal loop diagrams to capture the interconnectedness and complexity of food systems, diet, and obesity, along with gaps in the geographical coverage of study efforts, as well as the representation of key populations in current conceptualizations of food systems. This review offers methodological insights for researchers and practitioners seeking to apply causal loop diagrams to understand and address complex public health issues related to food systems, diet, and obesity within their local contexts.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 11","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Father-Focused Childhood Obesity Prevention Interventions: A Scoping Review.","authors":"Sarah Latkolik, Paulina Morelli, In Young Park, Ryan Koop, Brian K Lo","doi":"10.1111/obr.13970","DOIUrl":"https://doi.org/10.1111/obr.13970","url":null,"abstract":"<p><p>Father-focused childhood obesity prevention interventions are emerging as novel strategies to tackle increasing childhood obesity rates. This scoping review aimed to describe the characteristics of these interventions and their participants to identify knowledge gaps and improve future interventions. A search for eligible interventions was conducted in MEDLINE (Ovid), Web of Science, and CINAHL (EBSCO) between 2023 and 2024 without date or geographic restrictions. Data were extracted using a tool developed for this review and analyzed using content analysis. Fourteen unique interventions were identified and were all conducted in developed Western countries (n = 14). Most were implemented between 2015 and 2019 (n = 9) in community settings (n = 13) and were feasibility and efficacy trials (n = 11). Most interventions targeted elementary school-aged (6-10 years) (n = 8) and middle school-aged (11-13 years) children (n = 8), followed by preschool-kindergarten-aged children (2-5 years) (n = 7); none targeted high school-aged children (14-17 years). Most interventions targeted physical activity parenting (n = 14) and sedentary behavior parenting (n = 13), with less focus on food parenting (n = 11) and sleep parenting (n = 0). Fathers from nontraditional families and racial/ethnic minority groups were underrepresented and underreported. Our findings underscore the need to increase the emphasis on food and sleep parenting in father-focused interventions and to include fathers from diverse backgrounds to address health disparities.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13970"},"PeriodicalIF":8.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Tirzepatide on Weight Loss in Patients Without Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Sharath Kommu,&nbsp;Param P. Sharma,&nbsp;Rachel M. Gabor","doi":"10.1111/obr.13961","DOIUrl":"10.1111/obr.13961","url":null,"abstract":"<p>Tirzepatide has positive effects on weight loss in individuals with overweight or obesity. Considering its broad side-effect profile, its efficacy and safety in individuals without diabetes mellitus (DM) are yet to be fully understood. To address this, we conducted a comprehensive meta-analysis of six randomized trials on individuals with overweight or obesity, without DM, which showed that tirzepatide, when compared with placebo, resulted in a change in percentage body weight with a mean difference (MD) of −16.32% (95% CI: −18.35 to −14.29) and change in absolute body weight in kilograms (MD −13.95 kg; −18.83 to −9.07). There were significant reductions in body mass index and waist circumference when compared with placebo, with MDs of −5.89 kg/m² (−8.97 to −2.81) and −12.31 cm (−13.93 to −10.68), respectively. It was associated with gastrointestinal (GI) side effects: nausea (relative risk [RR] 3.11; 2.74–3.54), vomiting (RR 5.94; 4.50–7.85), diarrhea (RR 2.92; 2.53–3.37), and constipation (RR 2.85; 2.38–3.42). Serious adverse events were not statistically significant (RR 0.93; 0.76–1.13), but serious GI events and discontinuation due to adverse events were significant (RRs 3.07; 2.03–4.66, and 2.29; 1.74–3.01, respectively). In conclusion, this meta-analysis suggests that in patients with overweight or obesity without DM, tirzepatide is effective for significant weight loss. Though the overall risk of serious adverse events is not higher compared with placebo, it carries an elevated risk of GI side effects, serious GI events, and discontinuation due to adverse effects.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 11","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13961","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Circulating Interleukin Concentrations in Type 2 Diabetes: A Systematic Review and Meta-Analysis.","authors":"Chang Cao, Jing Yuan, Elizabeth R Gilbert, Mark A Cline, Fan Lam, King C Li, Ryan N Dilger","doi":"10.1111/obr.13971","DOIUrl":"https://doi.org/10.1111/obr.13971","url":null,"abstract":"<p><strong>Objectives: </strong>This work aimed to quantitatively evaluate circulating interleukin concentration data available for patients with Type 2 diabetes.</p><p><strong>Methods: </strong>We performed a systematic review using PubMed, Web of Science, and the Cochrane Library. Original studies reporting data on circulating interleukin concentrations in at least one group of patients with Type 2 diabetes (obese Type 2 diabetes [OBD], overweight Type 2 diabetes [OWD], or lean Type 2 diabetes [LD]) and healthy weight controls (HWCs) were included. Data were extracted from 43 included studies uniquely encompassing 2646 patients with Type 2 diabetes and 6605 HWCs by independent investigators. We used a random-effects model to pool data in the Comprehensive Meta-Analysis Version 2 software. Effect sizes (ESs) were calculated as the standardized mean difference in interleukin concentrations between groups and then transformed into Hedge's g statistic.</p><p><strong>Results: </strong>Our results revealed higher circulating concentrations in patients with Type 2 diabetes compared with HWCs, including IL-4, IL-6, IL-17, and IL-18. When stratified by BMI subgroups, all patients with Type 2 diabetes displayed elevated IL-6 concentrations compared with HWCs, with OBD patients having the highest ES, followed by OWD and LD. Similar to the overall results, higher interleukin concentrations in different BMI subgroups of patients with Type 2 diabetes were observed compared with HWCs in IL-4 (OWD), IL-17 (LD), and IL-18 (OBD, but not OWD).</p><p><strong>Conclusion: </strong>Meta-analysis outcomes demonstrated higher circulating concentrations of IL-4, IL-6, IL-17, and IL-18 in patients with Type 2 diabetes, strengthening the clinical evidence that Type 2 diabetes is accompanied by a systemic inflammatory response.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13971"},"PeriodicalIF":8.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}