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Obesity-Related Coagulation Activation in Adolescents and Children: A Systematic Review and Meta-Analysis 青少年和儿童肥胖相关凝血激活:系统回顾和荟萃分析。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-04-26 DOI: 10.1111/obr.70137
Julia Buchold, Hans-Jonas Meyer, Manuel Florian Struck, Shrey Kohli, Akash Mathew, Gyulten Mangova, Alexey Surov, Matthias Blüher, Berend Isermann, Silke Zimmermann
{"title":"Obesity-Related Coagulation Activation in Adolescents and Children: A Systematic Review and Meta-Analysis","authors":"Julia Buchold,&nbsp;Hans-Jonas Meyer,&nbsp;Manuel Florian Struck,&nbsp;Shrey Kohli,&nbsp;Akash Mathew,&nbsp;Gyulten Mangova,&nbsp;Alexey Surov,&nbsp;Matthias Blüher,&nbsp;Berend Isermann,&nbsp;Silke Zimmermann","doi":"10.1111/obr.70137","DOIUrl":"10.1111/obr.70137","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Obesity is recognized as a pro-thrombotic condition, yet the extent of coagulation activation across biomarkers remains unclear. This meta-analysis evaluates the impact of obesity on parameters—D-dimer, fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF), factor VIII (FVIII), and endogenous thrombin potential (ETP)—in children and adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty-four studies comprising 59,503 individuals were analyzed. Plasma biomarker levels were compared between non-obese and obese groups using standardized mean differences (SMDs), with subgroup analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>D-dimer was significantly elevated in adults with obesity (SMD 1.36, 95% CI 0.47–2.25, <i>p</i> = 0.003) and children with obesity (SMD 0.77, 95% CI 0.19–1.36, <i>p</i> = 0.009), indicating increased fibrin turnover. Fibrinogen levels were markedly higher in both adults (SMD 1.17, 95% CI 0.14–2.20, <i>p</i> = 0.03) and children (SMD 1.43, 95% CI 0.93–1.92, <i>p</i> &lt; 0.0001). PAI-1 showed the most pronounced increase in adults (SMD 2.30, 95% CI 0.1.51–3.09, <i>p</i> &lt; 0.0001) and children (SMD 3.54, 95% CI 1.65–5.43, <i>p</i> = 0.0002). FVIII levels were modestly elevated (SMD 0.52, 95% CI 0.10–0.94, <i>p</i> = 0.02), whereas vWF levels showed inconsistent changes. ETP was significantly higher in obesity, in children (SMD 1.06, 95% CI 0.24–1.88, <i>p</i> = 0.01) and adults (SMD 0.71, 95% CI 0.46–0.97, <i>p</i> &lt; 0.0001). Gender-stratified data indicated higher PAI-1, fibrinogen, and ETP levels in females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Obesity is associated with increased coagulation activation, suggesting a pro-thrombotic shift. These findings support the need for age- and gender-specific research into obesity-related hemostatic alterations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.70137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein Decoys, Alcohol, and Energy Intake: Testing a Mechanistic-Ecological Model 蛋白质诱饵、酒精和能量摄入:检验一个机械生态学模型。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-05-19 DOI: 10.1111/obr.70138
Amanda Grech, Stephen J. Simpson, David Raubenheimer
{"title":"Protein Decoys, Alcohol, and Energy Intake: Testing a Mechanistic-Ecological Model","authors":"Amanda Grech,&nbsp;Stephen J. Simpson,&nbsp;David Raubenheimer","doi":"10.1111/obr.70138","DOIUrl":"10.1111/obr.70138","url":null,"abstract":"<p>Ultra-processed diets are associated with excessive energy intake, but studies examining the role of alcohol have produced conflicting results, despite the high energy density of ethanol. We constructed a mechanistic-ecological model to explain this inconsistency and tested its predictions using population dietary data. The model builds on experimentally established mechanisms to predict that, whereas alcohol will contribute ethanol calories irrespective of diet, its impact on total macronutrient energy intake varies depending on dietary pattern. Alcohol consumption stimulates FGF21, a hormone that increases savory (umami) preference and reduces sweet preference. In minimally processed food environments—where umami flavor is a relatively reliable indicator of protein in foods—umami-seeking should direct consumers toward satiating, high-protein foods, with limited effect on macronutrient energy intake. In contrast, on diets rich in ultra-processed savory foods and/or high-fat unprocessed meats, the correlation between umami flavor characteristics and protein is broken by umami-flavored low-protein foods (protein decoys), so alcohol instead drives dietary protein dilution and, through attenuated protein satiation, increased food and macronutrient energy intake (protein leverage). Mixture analysis paired with nutritional geometry confirmed these predictions in population data, suggesting the model may generalize to ecological contexts. Our results potentially explain why alcohol has variable effects on energy balance across dietary patterns and suggest that it exacerbates the obesogenic effects of ultra-processed diets—a potentially important interaction given their global rise.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Male Sexual Function: A Systematic Review and Meta-Analysis Roux-en-Y胃旁路术和袖式胃切除术对男性性功能的影响:系统综述和meta分析。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-04-21 DOI: 10.1111/obr.70136
Mohamed Hany, Mohamed H. Zidan, Hashem Altabbaa, Ahmed El Shamarka, Marwan Emad Abdou, Mohamed Al Sayed, Bart Torensma
{"title":"Effect of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Male Sexual Function: A Systematic Review and Meta-Analysis","authors":"Mohamed Hany,&nbsp;Mohamed H. Zidan,&nbsp;Hashem Altabbaa,&nbsp;Ahmed El Shamarka,&nbsp;Marwan Emad Abdou,&nbsp;Mohamed Al Sayed,&nbsp;Bart Torensma","doi":"10.1111/obr.70136","DOIUrl":"10.1111/obr.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Obesity negatively impacts male sexual function and fertility through hormonal imbalances, endothelial dysfunction, and psychosocial factors. Metabolic and bariatric surgery (MBS) constitutes an effective intervention; however, procedure-stratified changes in male reproductive parameters after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) remain incompletely synthesized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>A systematic search of PubMed, Embase, Cochrane Library, Scopus, and Web of Science was conducted in November 2024. Sexual function, testosterone levels, and semen quality were included. Risk of bias was assessed using MINORS criteria. Random-effects meta-analyses were performed separately for each surgical modality, with heterogeneity quantified via <i>I</i><sup>2</sup> statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-one studies comprising 848 patients were included. Meta-analysis of pre–post data demonstrated that both RYGB and SG were independently associated with improvements in sex hormone–binding globulin and testosterone levels. In studies examining SG, significant improvements were observed in erectile function (SMD: 1.38, 95% CI: 0.66–2.10, <i>p</i> = 0.0002) and sperm concentration (SMD: 0.91, 95% CI: 0.56–1.26, <i>p</i> &lt; 0.00001). Studies evaluating RYGB did not demonstrate statistically significant changes in erectile function (SMD: 0.62, 95% CI: −0.06 to 1.30, <i>p</i> = 0.07) or sperm concentration (SMD: −0.01, 95% CI: −0.45 to 0.42, <i>p</i> = 0.95).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The meta-analytical findings suggest beneficial effects of both RYGB and SG on male hormonal parameters. Studies of SG demonstrated significant improvements in erectile function and sperm concentration. However, direct comparative analyses between the two procedures were not performed, precluding definitive conclusions regarding their relative efficacy. Future research necessitates head-to-head comparisons with standardized reproductive endpoints and extended follow-up periods.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of Meal Satisfaction and Their Association With Childhood Obesity: A Systematic Review 膳食满意度的决定因素及其与儿童肥胖的关系:一项系统综述。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-05-14 DOI: 10.1111/obr.70134
M. Noemy Pastore, Ana Velasco-Andonegui, Gerry Jager, Eva Almiron-Roig
{"title":"Determinants of Meal Satisfaction and Their Association With Childhood Obesity: A Systematic Review","authors":"M. Noemy Pastore,&nbsp;Ana Velasco-Andonegui,&nbsp;Gerry Jager,&nbsp;Eva Almiron-Roig","doi":"10.1111/obr.70134","DOIUrl":"10.1111/obr.70134","url":null,"abstract":"<p>Meal satisfaction is considered a multidimensional concept that includes sensory enjoyment, cognitive, emotional, and physiological components and relates to contentment with the meal experience as a whole. However, its relevance to eating behavior and body weight remains unclear, especially in children. The present review investigated the potential relationship between meal satisfaction-related constructs and childhood obesity, and whether this relation is shaped by individual factors and the external environment. Seventeen eligible studies from 350 records published between 2008 and 2024 were included. No study directly assessed meal satisfaction; instead, proxy measures were used. Food enjoyment emerged as the proxy most consistently associated with BMI, often clustering with higher food responsiveness, lower satiety responsiveness, and emotional overeating. Parental feeding practices, especially pressure to eat, significantly contributed to variation in children's eating behavior and were associated with lower food enjoyment. Overall, meal satisfaction could be a key aspect to consider in childhood obesity prevention programs. However, to date, the available evidence is heterogeneous and predominantly observational. Future longitudinal and intervention studies are needed, alongside child-appropriate instruments to objectively quantify food satisfaction in children. Research that helps understand the role of contextual eating factors on children's meal satisfaction and eating behavior is also warranted.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.70134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Moderate-Frequency Resistance Training on Cardiometabolic Risk Factors in Adults With Overweight or Obesity: A Systematic Review and Meta-Analysis 中频阻力训练对超重或肥胖成人心脏代谢危险因素的影响:系统回顾和荟萃分析
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-03-17 DOI: 10.1111/obr.70130
Yigao Wu, Yunqing Zhang, Yixuan Li, Hiu Tin, Yanchun Li, Xu Yan
{"title":"Effects of Moderate-Frequency Resistance Training on Cardiometabolic Risk Factors in Adults With Overweight or Obesity: A Systematic Review and Meta-Analysis","authors":"Yigao Wu,&nbsp;Yunqing Zhang,&nbsp;Yixuan Li,&nbsp;Hiu Tin,&nbsp;Yanchun Li,&nbsp;Xu Yan","doi":"10.1111/obr.70130","DOIUrl":"10.1111/obr.70130","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Resistance training (RT) effectively manages cardiometabolic risk factors in adults, but the specific effects of moderate-frequency RT (2–3 sessions/week) in adults with overweight or obesity are understudied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate moderate-frequency RT's effects on cardiometabolic risk factors in this population and quantify effect sizes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Data Sources</h3>\u0000 \u0000 <p>PubMed, Web of Science, EMBASE, and Cochrane Library searched up to July 2025.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Eligibility</h3>\u0000 \u0000 <p>English randomized controlled trials (RCTs) comparing RT (≥ 7 weeks) to nonexercise control; nonathletic adults ≥ 18 years with BMI ≥ 25 kg/m<sup>2</sup>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>454 participants across 12 RCTs (mean age 58.93 ± 12.87 years; mean BMI 31.2 ± 3.5 kg/m<sup>2</sup>; ~50% female).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>RT significantly reduced diastolic blood pressure (MD = −1.53 mmHg; 95% CI: −2.16 to −0.91; <i>p</i> &lt; 0.01), LDL-C (MD = −0.25 mmol/L; 95% CI: −0.41 to −0.08; <i>p</i> &lt; 0.01), and triglycerides (MD = −0.17 mmol/L; 95% CI: −0.30 to −0.04; <i>p</i> = 0.01). No significant effects on systolic blood pressure, mean arterial pressure, waist circumference, glycemic markers, total cholesterol, or HDL-C. Subgroup analyses showed larger LDL-C/triglyceride improvements with concurrent dietary control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Moderate-frequency RT inconsistently improves cardiometabolic risk factors, benefiting diastolic blood pressure, LDL-C, and triglycerides but not glycemic or other parameters. Combining with dietary control may enhance benefits, supporting RT as a complementary strategy in multimodal lifestyle interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration PROSPERO: CRD42022343167.</h3>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Does the Ultra-Processed Food Industry Drive Consumption Through Product Design and Marketing? Mapping a Complex Commercial System According to Expert Mental Models and Evidence Review 超加工食品行业如何通过产品设计和营销推动消费?基于专家心智模型和证据回顾的复杂商业系统映射。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-04-09 DOI: 10.1111/obr.70135
Joshua Clark, Boyd Swinburn, Benjamin Wood, Gary Sacks, Kim Anastasiou, Penelope Milsom, Phillip Baker, Kelly Garton
{"title":"How Does the Ultra-Processed Food Industry Drive Consumption Through Product Design and Marketing? Mapping a Complex Commercial System According to Expert Mental Models and Evidence Review","authors":"Joshua Clark,&nbsp;Boyd Swinburn,&nbsp;Benjamin Wood,&nbsp;Gary Sacks,&nbsp;Kim Anastasiou,&nbsp;Penelope Milsom,&nbsp;Phillip Baker,&nbsp;Kelly Garton","doi":"10.1111/obr.70135","DOIUrl":"10.1111/obr.70135","url":null,"abstract":"<p>The corporations that produce and profit from ultra-processed foods (UPFs), and the regulatory conditions under which they operate, have been major contributors to the global rise of obesity and noncommunicable diseases. The aim was to map the drivers and feedback systems of the product design and marketing domains of the UPF system and to consider the implications for potential intervention strategies designed to improve population diets. A systems dynamics methodology, underpinned by a narrative literature review, was used to develop causal loop diagrams of the product design and marketing domains, through an iterative refinement process. Both domains contain multiple key drivers, alongside seven reinforcing feedback loops in the product design diagram and five in the marketing diagram. These loops predominantly focused on generating perceived value for the products, driving sales, and collecting data and information to further optimize product design and marketing strategies, serving the purpose of growing profits for UPF corporations. At many points, elements of human physiology and behavior are embedded in these feedback loops and are being manipulated or exploited by UPF corporations for this purpose. The research highlights multiple areas for intervention that, if implemented concurrently, can alter the dynamics of the current system such that power and control shift towards other types of food producers, communities, and citizens rather than UPF corporations.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.70135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Weight Loss Programs: A Meta-Analysis of Financial Incentives and Behavior Change Techniques 加强减肥计划:财政激励和行为改变技术的元分析。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-03-18 DOI: 10.1111/obr.70124
Sara M. Hondmann, Milon H. M. van Vliet, Roxy A. van Eersel, Linda D. Breeman, Mike Keesman, David R. de Buisonjé, George Haroon, Roderik Kraaijenhagen, Veronica R. Janssen, Andrea W. M. Evers
{"title":"Enhancing Weight Loss Programs: A Meta-Analysis of Financial Incentives and Behavior Change Techniques","authors":"Sara M. Hondmann,&nbsp;Milon H. M. van Vliet,&nbsp;Roxy A. van Eersel,&nbsp;Linda D. Breeman,&nbsp;Mike Keesman,&nbsp;David R. de Buisonjé,&nbsp;George Haroon,&nbsp;Roderik Kraaijenhagen,&nbsp;Veronica R. Janssen,&nbsp;Andrea W. M. Evers","doi":"10.1111/obr.70124","DOIUrl":"10.1111/obr.70124","url":null,"abstract":"<p>Obesity is a risk factor for chronic illness. Financial incentives contingent on behaviors or outcomes related to weight loss can promote weight loss efforts. This meta-analysis examines the added effect of financial incentives for weight loss in health behavior change interventions, both short- and long-term, in adults. Additionally, subgroup analyses explored incentive targets (physiological outcomes, lifestyle behaviors, process behaviors, or multiple targets) and types of behavior change techniques (BCTs; interactive or passive) as moderators. Seven databases were systematically searched for (quasi-)randomized control trial studies. The meta-analysis included 29 studies with incentive and control conditions, 2396 adults in control and 3397 in incentive conditions. Using a random-effects model, results showed a small, significant, positive effect of incentives on weight loss during the incentive phase (i.e., short-term; 51 comparisons; SMD = 0.180, <i>p</i> &lt; 0.001) but not in the post-incentive phase (i.e., long-term, after incentive removal; 23 comparisons; SMD = 0.032, <i>p</i> = 0.432). However, limited studies reported post-incentive data. In the incentive phase, subgroup analyses showed that incentivizing multiple targets and physiological outcomes has a larger effect than incentivizing lifestyle and process behaviors. Subgroup analyses showed no significant effect of type of BCTs. However, in the incentive phase, the within-group analysis showed that combining incentives with interactive BCTs had a significant effect while passive BCTs did not. Suggesting that combining incentives only with passive BCTs may not be sufficient to achieve weight loss, given its complexity. In conclusion, these findings suggest that financial incentive interventions are effective on short-term weight loss, especially when incentivizing multiple targets or physiological outcomes.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147471913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Efficacy of Pharmacotherapy Intervention on Anthropometric Outcomes in Survivors of Childhood Brain Tumors: An Updated Systematic Review and Meta-Analysis 药物治疗干预对儿童脑肿瘤幸存者人体测量结果的影响:一项最新的系统综述和荟萃分析。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-04-01 DOI: 10.1111/obr.70126
David Hart, Lawrence Mbuagbaw, Joseph Beyene, Marwa Akola, Sarah Burrow, M. Constantine Samaan, Lehana Thabane, Adam Fleming, Donna L. Johnston, Shahrad R. Rassekh, Laura Banfield, Russell J. de Souza
{"title":"The Efficacy of Pharmacotherapy Intervention on Anthropometric Outcomes in Survivors of Childhood Brain Tumors: An Updated Systematic Review and Meta-Analysis","authors":"David Hart,&nbsp;Lawrence Mbuagbaw,&nbsp;Joseph Beyene,&nbsp;Marwa Akola,&nbsp;Sarah Burrow,&nbsp;M. Constantine Samaan,&nbsp;Lehana Thabane,&nbsp;Adam Fleming,&nbsp;Donna L. Johnston,&nbsp;Shahrad R. Rassekh,&nbsp;Laura Banfield,&nbsp;Russell J. de Souza","doi":"10.1111/obr.70126","DOIUrl":"10.1111/obr.70126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Many survivors of childhood brain tumors face long-term adverse health outcomes like obesity. Uncertainties surround the effect of interventions to manage obesity-related outcomes in survivors of childhood brain tumors. The goal of this updated systematic review and meta-analysis was to provide the best estimate of the treatment efficacy of pharmacotherapy intervention on anthropometric outcomes in this pediatric population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We searched CENTRAL, MEDLINE, EMBASE, CINAHL, PsycINFO, PubMed, ClinicalTrials.gov, and ProQuest for articles published from January 1, 2015, to January 31, 2025. A meta-analysis was performed using the generic inverse-variance method in RevMan 5.4. Heterogeneity was assessed using the Cochrane Q test and the I<sup>2</sup> statistic. We used the GRADE approach to determine the certainty of evidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of six studies met the inclusion criteria: four newly identified studies published after January 1, 2015 (125 participants), and two from the previously published review (23 participants). The pooled estimate showed no significant change in body mass index z-score after intervention (mean difference = −0.02; 95% CI: −0.06 to 0.02, I<sup>2</sup> = 0%; 4 studies, 94 participants; low certainty of evidence). Similar pooled effects were observed across other outcomes; however, individual studies reported significant changes in some outcomes within the treatment groups after the intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pharmacological agents showed no significant change in anthropometric outcomes for survivors of childhood brain tumors. Further trials are needed to assess the efficacy of pharmacological agents and to identify subgroups most likely to benefit.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.70126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Socioeconomic Inequalities in Exposure to Neighborhood Food Environments: A Systematic Review. 暴露于邻里食物环境中的社会经济不平等:一项系统综述。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 DOI: 10.1111/obr.70222
Jet D S van de Geest, Kamille Almer Bernsdorf, Paul Meijer, Julia Diez, Kirsten Bjørnsbo, Linda J Schoonmade, Jeroen Lakerveld
{"title":"Socioeconomic Inequalities in Exposure to Neighborhood Food Environments: A Systematic Review.","authors":"Jet D S van de Geest, Kamille Almer Bernsdorf, Paul Meijer, Julia Diez, Kirsten Bjørnsbo, Linda J Schoonmade, Jeroen Lakerveld","doi":"10.1111/obr.70222","DOIUrl":"https://doi.org/10.1111/obr.70222","url":null,"abstract":"<p><strong>Introduction: </strong>Socioeconomic inequalities in dietary behaviors and consequent health outcomes may be partly driven by unequal exposure to neighborhood food environments. This systematic review synthesized evidence on individual- and area-level socioeconomic inequalities in exposure to neighborhood food environments in high-income countries.</p><p><strong>Methods: </strong>We conducted systematic searches in MEDLINE, Embase, Web of Science, and Scopus in February 2024 and updated the search in April 2026. Eligible studies were quantitative, included objective food environment measures and reported at least one indicator of socioeconomic position (SEP). Title and abstract screening was supported by ASReview with all decisions made manually; full texts were screened in duplicate. Data extraction followed a predefined form, and study quality was assessed using an adapted version of the AXIS tool. Results were synthesized narratively and by reporting the proportion of associations indicating relatively advantageous, disadvantageous, or nonstatistically significant differences in exposure for populations with a lower SEP.</p><p><strong>Results: </strong>A total of 167 studies were included. Populations with lower SEP tended to experience modestly greater exposure to some unhealthy food outlets, while differences in exposure to healthy outlets were predominantly mixed or nonstatistically significant. Substantial heterogeneity was observed across SEP indicators, food environment measures, geographical contexts, levels of analysis, and statistical approaches, limiting comparability across studies and precluding meta-analysis.</p><p><strong>Conclusion: </strong>Neighborhood food environments in high-income countries show modest but meaningful socioeconomic inequalities, driven mainly by higher exposure to some unhealthy outlets among populations with a lower SEP. Addressing these disparities may require more standardized exposure measures and equity-focused policy approaches.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70222"},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Incidence of Suicide Following Metabolic and Bariatric Surgery: A Prognosis Systematic Review and Meta-Analysis of Longitudinal Studies 代谢和减肥手术后自杀的发生率:纵向研究的预后系统回顾和荟萃分析。
IF 7.6 2区 医学
Obesity Reviews Pub Date : 2026-09-08 Epub Date: 2026-03-16 DOI: 10.1111/obr.70129
Li-Feng Shang, Ke-Lu Yang, Xin-Yu Zhang, Xin Shen, Ke-Wei Jiang, Chunhu Shi, Quan Wang, Hai Shi
{"title":"The Incidence of Suicide Following Metabolic and Bariatric Surgery: A Prognosis Systematic Review and Meta-Analysis of Longitudinal Studies","authors":"Li-Feng Shang,&nbsp;Ke-Lu Yang,&nbsp;Xin-Yu Zhang,&nbsp;Xin Shen,&nbsp;Ke-Wei Jiang,&nbsp;Chunhu Shi,&nbsp;Quan Wang,&nbsp;Hai Shi","doi":"10.1111/obr.70129","DOIUrl":"10.1111/obr.70129","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Metabolic and bariatric surgery (MBS) effectively manages severe obesity but may lead to psychological complications such as completed suicides and suicide attempts. This review aimed to analyze suicide and self-harm incidence post-MBS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We searched MEDLINE, EMBASE, PsycINFO, and the Cochrane Library databases on August 16, 2022, for longitudinal studies with incidence data on suicide following MBS. We performed a single proportion meta-analysis on the incidence of outcomes and assessed the certainty of evidence using the GRADE approach. The review was registered with PROSPERO (CRD42022352137).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighty-four studies were included. The meta-analysis showed an incidence of 230.64 suicides per 100,000 participants (95% CI: 167.51 to 317.49) in pooled individual-level data and an incidence of 43.02 suicides per 100,000 person-years (95% CI: 32.49 to 56.97) in pooled person-year data. Evidence was low certainty or very low certainty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The average suicide incidence (231 per 100,000 people) in people with obesity who underwent MBS significantly exceeded the 2019 WHO global estimate for the general population (nine per 100,000 people). These findings underscore the need to incorporate structured psychological screening and follow-up into the perioperative management process of MBS, as patient mental health may play a pivotal role in postoperative adherence and long-term outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"27 10","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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