Obesity Reviews最新文献_第5页

Complex Interplay Between Obesity and BRCA1/2-Associated Breast Cancer: An Overview. 肥胖与brca1 /2相关乳腺癌之间复杂的相互作用：综述

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-16 DOI: 10.1111/obr.13969

Cinzia Giordano, Marianna Puzzo, Rocco Malivindi, Debora Cristofaro, Luca Gelsomino, Daniela Bonofiglio, Carlo Capalbo, Sebastiano Andò, Ines Barone, Stefania Catalano

{"title":"Complex Interplay Between Obesity and BRCA1/2-Associated Breast Cancer: An Overview.","authors":"Cinzia Giordano, Marianna Puzzo, Rocco Malivindi, Debora Cristofaro, Luca Gelsomino, Daniela Bonofiglio, Carlo Capalbo, Sebastiano Andò, Ines Barone, Stefania Catalano","doi":"10.1111/obr.13969","DOIUrl":"https://doi.org/10.1111/obr.13969","url":null,"abstract":"The steadily increasing prevalence of obesity and its association with a growing number of malignancies, including breast cancer, has made this disease spectrum an urgent and critical public health priority, demanding immediate attention and comprehensive action. To date, a growing body of research has been dedicated to the study of obesity/breast cancer biological link, with the most well-documented mechanisms involving chronic inflammation, altered adipokine levels, dysregulated hormone signaling, and insulin/growth factor pathways. Despite significant progress, a substantial gap persists in our present comprehension of the association between adiposity and breast cancer biology in individuals with mutations in the BRCA1/2 genes, the most widely known high-penetrance genes involved in severe breast cancer risk. In this review, we first give an overview of the contribution of BRCA1/2 gene mutations in breast cancer development. Then, we discuss the emerging mechanistic evidence linking obesity with breast cancer, highlighting the impact of metabolic and hormonal factors in BRCA mutation carriers. Insights into the cross-talk between obesity and breast cancer development in BRCA mutation carriers may pave the way to improve proper personalized clinical management of BRCA1/2-associated breast cancer.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13969"},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Street Food Availability on Nutritional Intake and Diet-Related Health Outcomes: A Systematic Review. 街头食品供应对营养摄入和饮食相关健康结果的影响：一项系统综述。

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-16 DOI: 10.1111/obr.13964

Jose-Benito Rosales Chavez, Mariana Romo-Avila, Luis Ortiz-Hernandez

{"title":"Impact of Street Food Availability on Nutritional Intake and Diet-Related Health Outcomes: A Systematic Review.","authors":"Jose-Benito Rosales Chavez, Mariana Romo-Avila, Luis Ortiz-Hernandez","doi":"10.1111/obr.13964","DOIUrl":"https://doi.org/10.1111/obr.13964","url":null,"abstract":"The community food environment influences access to food, which depends on the type of food venues available. However, studies predominantly focus on the Global North, often neglecting culturally relevant food sources in the Global South, like street food (SF) stalls. SF are a popular, affordable, and convenient source of energy and nutrients, but research mainly addresses food safety rather than their impact on diet-related non-communicable diseases. This systematic review evaluates SF's roles in food, energy, and nutrient consumption and health outcomes globally. Our team reviewed peer-reviewed articles from eight databases in English, Spanish, and Portuguese, using combinations of key terms related to SF, nutrition, and body weight. A total of 129 articles met the criteria. Findings indicate SF include different items of varied food groups, nutritional contents, and processing extents. SF are vital for providing food access, especially in urban areas near worksites and schools. However, only seven studies explored the link between SF consumption and cardiometabolic risk, showing mixed results. Future research with longitudinal design is necessary for establishing clearer health-impact relationships.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13964"},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Leptin Is a Potential Biomarker of Childhood Obesity and an Indicator of the Effectiveness of Weight-Loss Interventions". 对“瘦素是儿童肥胖的潜在生物标志物和减肥干预措施有效性的指标”的更正。

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-15 DOI: 10.1111/obr.13972

引用次数: 0

Causal Loop Diagrams of Food Systems, Diet, and Obesity: A Scoping Review of Methods, Contextual Factors, and Outcomes. 食物系统、饮食和肥胖的因果循环图：方法、背景因素和结果的范围审查。

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-15 DOI: 10.1111/obr.13966

Ivana Stankov, Andres Useche, Peter Lekkas, Rosie Mae Henson, Irene Headen, Jonathan Purtle, Brent A Langellier

{"title":"Causal Loop Diagrams of Food Systems, Diet, and Obesity: A Scoping Review of Methods, Contextual Factors, and Outcomes.","authors":"Ivana Stankov, Andres Useche, Peter Lekkas, Rosie Mae Henson, Irene Headen, Jonathan Purtle, Brent A Langellier","doi":"10.1111/obr.13966","DOIUrl":"https://doi.org/10.1111/obr.13966","url":null,"abstract":"This scoping review characterizes the literature on qualitative systems methodologies that guide interest-holders in developing causal loop diagrams focused on food systems, diet, and obesity. Peer-reviewed research using interest-holder-driven causal loop diagrams to examine food environments, access, purchasing, diet, obesity, and related interventions/policies was included. A comprehensive search of six databases (ProQuest Central, Scopus, Web of Science, Ovid MEDLINE, Embase, and Emcare) yielded 40 eligible studies from a pool of 1370 unique records. We synthesize study characteristics, the intended uses of causal loop diagrams, methodological approaches, evaluation processes, and key findings. While all studies identified individual and behavioral drivers of obesity, studies based in the Global South more frequently featured structural factors such as racism, discrimination, crime, and incarceration. Papers focused on engaging minoritized populations similarly emphasized structural-level themes such as urban agriculture, gentrification, community investment, and capacity building. Our findings highlight the potential of causal loop diagrams to capture the interconnectedness and complexity of food systems, diet, and obesity, along with gaps in the geographical coverage of study efforts, as well as the representation of key populations in current conceptualizations of food systems. This review offers methodological insights for researchers and practitioners seeking to apply causal loop diagrams to understand and address complex public health issues related to food systems, diet, and obesity within their local contexts.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13966"},"PeriodicalIF":8.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Father-Focused Childhood Obesity Prevention Interventions: A Scoping Review. 以父亲为中心的儿童肥胖预防干预：范围综述。

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-13 DOI: 10.1111/obr.13970

Sarah Latkolik, Paulina Morelli, In Young Park, Ryan Koop, Brian K Lo

{"title":"Father-Focused Childhood Obesity Prevention Interventions: A Scoping Review.","authors":"Sarah Latkolik, Paulina Morelli, In Young Park, Ryan Koop, Brian K Lo","doi":"10.1111/obr.13970","DOIUrl":"https://doi.org/10.1111/obr.13970","url":null,"abstract":"Father-focused childhood obesity prevention interventions are emerging as novel strategies to tackle increasing childhood obesity rates. This scoping review aimed to describe the characteristics of these interventions and their participants to identify knowledge gaps and improve future interventions. A search for eligible interventions was conducted in MEDLINE (Ovid), Web of Science, and CINAHL (EBSCO) between 2023 and 2024 without date or geographic restrictions. Data were extracted using a tool developed for this review and analyzed using content analysis. Fourteen unique interventions were identified and were all conducted in developed Western countries (n = 14). Most were implemented between 2015 and 2019 (n = 9) in community settings (n = 13) and were feasibility and efficacy trials (n = 11). Most interventions targeted elementary school-aged (6-10 years) (n = 8) and middle school-aged (11-13 years) children (n = 8), followed by preschool-kindergarten-aged children (2-5 years) (n = 7); none targeted high school-aged children (14-17 years). Most interventions targeted physical activity parenting (n = 14) and sedentary behavior parenting (n = 13), with less focus on food parenting (n = 11) and sleep parenting (n = 0). Fathers from nontraditional families and racial/ethnic minority groups were underrepresented and underreported. Our findings underscore the need to increase the emphasis on food and sleep parenting in father-focused interventions and to include fathers from diverse backgrounds to address health disparities.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13970"},"PeriodicalIF":8.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Tirzepatide on Weight Loss in Patients Without Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 替西帕肽对非糖尿病患者减肥的有效性和安全性：随机对照试验的系统评价和荟萃分析。

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-13 DOI: 10.1111/obr.13961

Sharath Kommu, Param P Sharma, Rachel M Gabor

{"title":"Efficacy and Safety of Tirzepatide on Weight Loss in Patients Without Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Sharath Kommu, Param P Sharma, Rachel M Gabor","doi":"10.1111/obr.13961","DOIUrl":"10.1111/obr.13961","url":null,"abstract":"Tirzepatide has positive effects on weight loss in individuals with overweight or obesity. Considering its broad side-effect profile, its efficacy and safety in individuals without diabetes mellitus (DM) are yet to be fully understood. To address this, we conducted a comprehensive meta-analysis of six randomized trials on individuals with overweight or obesity, without DM, which showed that tirzepatide, when compared with placebo, resulted in a change in percentage body weight with a mean difference (MD) of -16.32% (95% CI: -18.35 to -14.29) and change in absolute body weight in kilograms (MD -13.95 kg; -18.83 to -9.07). There were significant reductions in body mass index and waist circumference when compared with placebo, with MDs of -5.89 kg/m2 (-8.97 to -2.81) and -12.31 cm (-13.93 to -10.68), respectively. It was associated with gastrointestinal (GI) side effects: nausea (relative risk [RR] 3.11; 2.74-3.54), vomiting (RR 5.94; 4.50-7.85), diarrhea (RR 2.92; 2.53-3.37), and constipation (RR 2.85; 2.38-3.42). Serious adverse events were not statistically significant (RR 0.93; 0.76-1.13), but serious GI events and discontinuation due to adverse events were significant (RRs 3.07; 2.03-4.66, and 2.29; 1.74-3.01, respectively). In conclusion, this meta-analysis suggests that in patients with overweight or obesity without DM, tirzepatide is effective for significant weight loss. Though the overall risk of serious adverse events is not higher compared with placebo, it carries an elevated risk of GI side effects, serious GI events, and discontinuation due to adverse effects.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13961"},"PeriodicalIF":8.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Circulating Interleukin Concentrations in Type 2 Diabetes: A Systematic Review and Meta-Analysis. 2型糖尿病患者循环白细胞介素浓度升高：一项系统综述和荟萃分析

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-13 DOI: 10.1111/obr.13971

Chang Cao, Jing Yuan, Elizabeth R Gilbert, Mark A Cline, Fan Lam, King C Li, Ryan N Dilger

{"title":"Increased Circulating Interleukin Concentrations in Type 2 Diabetes: A Systematic Review and Meta-Analysis.","authors":"Chang Cao, Jing Yuan, Elizabeth R Gilbert, Mark A Cline, Fan Lam, King C Li, Ryan N Dilger","doi":"10.1111/obr.13971","DOIUrl":"https://doi.org/10.1111/obr.13971","url":null,"abstract":"Objectives: This work aimed to quantitatively evaluate circulating interleukin concentration data available for patients with Type 2 diabetes.Methods: We performed a systematic review using PubMed, Web of Science, and the Cochrane Library. Original studies reporting data on circulating interleukin concentrations in at least one group of patients with Type 2 diabetes (obese Type 2 diabetes [OBD], overweight Type 2 diabetes [OWD], or lean Type 2 diabetes [LD]) and healthy weight controls (HWCs) were included. Data were extracted from 43 included studies uniquely encompassing 2646 patients with Type 2 diabetes and 6605 HWCs by independent investigators. We used a random-effects model to pool data in the Comprehensive Meta-Analysis Version 2 software. Effect sizes (ESs) were calculated as the standardized mean difference in interleukin concentrations between groups and then transformed into Hedge's g statistic.Results: Our results revealed higher circulating concentrations in patients with Type 2 diabetes compared with HWCs, including IL-4, IL-6, IL-17, and IL-18. When stratified by BMI subgroups, all patients with Type 2 diabetes displayed elevated IL-6 concentrations compared with HWCs, with OBD patients having the highest ES, followed by OWD and LD. Similar to the overall results, higher interleukin concentrations in different BMI subgroups of patients with Type 2 diabetes were observed compared with HWCs in IL-4 (OWD), IL-17 (LD), and IL-18 (OBD, but not OWD).Conclusion: Meta-analysis outcomes demonstrated higher circulating concentrations of IL-4, IL-6, IL-17, and IL-18 in patients with Type 2 diabetes, strengthening the clinical evidence that Type 2 diabetes is accompanied by a systemic inflammatory response.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13971"},"PeriodicalIF":8.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Key Predictors of Mid-Childhood Obesity in a Population-Based Cohort Study: An Evidence Synthesis and Predictive Modeling Study. 在一项基于人群的队列研究中确定儿童中期肥胖的关键预测因素：一项证据综合和预测模型研究。

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-12 DOI: 10.1111/obr.13958

Yuchan Mou, Susana Santos, Macarena Lara, Ivonne P M Derks, Vincent W V Jaddoe, Romy Gaillard, Janine F Felix, Eric Steegers, Trudy Voortman, Marinus H van IJzendoorn, Pauline W Jansen

{"title":"Identifying Key Predictors of Mid-Childhood Obesity in a Population-Based Cohort Study: An Evidence Synthesis and Predictive Modeling Study.","authors":"Yuchan Mou, Susana Santos, Macarena Lara, Ivonne P M Derks, Vincent W V Jaddoe, Romy Gaillard, Janine F Felix, Eric Steegers, Trudy Voortman, Marinus H van IJzendoorn, Pauline W Jansen","doi":"10.1111/obr.13958","DOIUrl":"https://doi.org/10.1111/obr.13958","url":null,"abstract":"A wide spectrum of predictors of childhood overweight and obesity has been identified over past decades, yet a quantitative overview of multidisciplinary predictors is missing, and the relative importance and their collective contribution to childhood obesity remains unclear. We synthesized evidence from 93 published studies from the Generation R Study, a population-based prospective cohort from early-pregnancy onwards in the Netherlands, to provide a quantitative overview of 210 predictors across preconception and childhood associated with body mass index (BMI) in mid-childhood and selected 59 candidate predictors. Then, we further identified 32 key predictors for either zBMI or weight status using model search algorithms and built prediction models with data from the same cohort. Associations of note were identified among predictors in preconception and prenatal parental health, early-life weight, and child behavior domains. An interquartile range increase in parental prepregnancy BMI (maternal β = 0.17, 95% CI: 0.14, 0.20; paternal β = 0.17, 95% CI: 0.14, 0.21), early-life weight (e.g., zBMI at age 2y β = 0.28, 95% CI: 0.23, 0.33), and food responsiveness (β = 0.25, 95% CI: 0.21, 0.28) were positively associated with mid-childhood BMI, and satiety responsiveness was negatively associated (β = -0.18, 95% CI: -0.21, -0.15). Together, identified key predictors accounted for 49.2% of the variance of BMI and 33.7% of the variance of the odds of overweight and obesity at the age of 10 years. Multimodal interventions targeting parental BMI before pregnancy, early adiposity rebound, and management of appetite in early childhood may be most effective in maintaining a healthy weight during childhood.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13958"},"PeriodicalIF":8.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to and Impact of Unhealthy Food Marketing on Adolescents and Young Adults: A Narrative Review and Research Agenda. 不健康食品营销对青少年和年轻人的影响：叙述回顾和研究议程。

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-10 DOI: 10.1111/obr.13957

Rositsa T Ilieva, Nava Gottlieb, Hailey Christian, Nicholas Freudenberg

{"title":"Exposure to and Impact of Unhealthy Food Marketing on Adolescents and Young Adults: A Narrative Review and Research Agenda.","authors":"Rositsa T Ilieva, Nava Gottlieb, Hailey Christian, Nicholas Freudenberg","doi":"10.1111/obr.13957","DOIUrl":"https://doi.org/10.1111/obr.13957","url":null,"abstract":"Consumption of unhealthy food has become a leading cause of premature deaths and preventable illnesses around the world. Research shows that marketing by the companies that produce, distribute, and sell unhealthy foods and beverages is associated with increased consumption of these products. To date, however, limited research has focused on the cumulative exposure and impact of various modes of marketing employed to reach distinct populations. In this narrative review, we summarize 25 years of scientific evidence and findings from 108 empirical studies and 19 systematic and scoping reviews of various forms of unhealthy food marketing to adolescents (aged 13 to 17) and young adults (aged 18 to 25). These are populations often targeted by food advertising, globally. The review offers insights into young people's exposure to unhealthy food marketing, how this exposure and its impacts vary by age, socioeconomic status, and race/ethnicity, and what is known about the cumulative effects of multi-platform food marketing. Our findings reveal patterns of disproportionate exposure among lower-income and racial/ethnic minority youth, especially Black and Latinx adolescents in the U.S., across different media platforms. Additionally, more than 90% of impact studies in our sample found that exposure to unhealthy food marketing is associated with higher consumption of advertised products, with social media influencer marketing gaining an increasingly prominent role. Despite emerging evidence on multi-platform marketing, cumulative exposure remains insufficiently researched. Based on these findings, we suggest paths for future research to reduce the harmful impact of marketing unhealthy food and beverages to young people.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13957"},"PeriodicalIF":8.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbiota-Derived Trimethylamine N-Oxide and the Risk of Diabetes: An Updated Systematic Review and Meta-Analysis. 肠道微生物来源的三甲胺n -氧化物与糖尿病的风险：最新的系统综述和荟萃分析。

IF 8 2区医学

Obesity Reviews Pub Date : 2025-06-10 DOI: 10.1111/obr.13963

Sammy Mohammadi, Maysa Eslami, Farzad Pourghazi, Hanieh-Sadat Ejtahed, Ehsan Shahrestanaki, Mostafa Qorbani, Shirin Hasani-Ranjbar, Bagher Larijani

{"title":"Gut Microbiota-Derived Trimethylamine N-Oxide and the Risk of Diabetes: An Updated Systematic Review and Meta-Analysis.","authors":"Sammy Mohammadi, Maysa Eslami, Farzad Pourghazi, Hanieh-Sadat Ejtahed, Ehsan Shahrestanaki, Mostafa Qorbani, Shirin Hasani-Ranjbar, Bagher Larijani","doi":"10.1111/obr.13963","DOIUrl":"https://doi.org/10.1111/obr.13963","url":null,"abstract":"Recent studies have discovered higher levels of circulating trimethylamine N-oxide, a metabolite produced by gastrointestinal microbiota, among patients diagnosed with diabetes. This study presents an updated systematic review and meta-analysis examining the association between trimethylamine N-oxide levels and the risk of developing diabetes. PubMed and Scopus databases were searched for the studies published up to April 2024. Observational (cross-sectional, case-control, and cohort) studies examining the relationship between TMAO levels and diabetes were included in our systematic review and meta-analysis, excluding non-original research, non-human studies, and non-English publications. Out of 1538 publications, 32 studies focusing on type 2 and gestational diabetes were included. We conducted two distinct meta-analyses investigating the association between TMAO levels and type 2 diabetes. First, we found significantly elevated TMAO levels in diabetic patients compared to non-diabetics (standardized mean difference [SMD]: 1.21, 95% confidence interval [CI]: 0.13-2.28). Second, we observed that elevated TMAO levels were associated with 49% increased odds of diabetes (odds ratio [OR]: 1.49, 95% CI: 1.06-2.10). However, the pooled hazard ratio (HR) analysis did not reveal a statistically significant association (HR: 1.00, 95% CI: 0.62, 1.61). Moreover, the included studies showed a higher type 2 diabetes prevalence in the elevated TMAO group. Regarding gestational diabetes, we also detected a positive correlation with TMAO levels. Our study indicates that individuals with type 2 diabetes have notably higher TMAO levels compared to non-diabetics. Furthermore, our systematic review suggests an elevated risk of developing both type 2 diabetes and gestational diabetes in individuals with higher TMAO levels.","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13963"},"PeriodicalIF":8.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0