Obesity Reviews最新文献

{"title":"Gut Microbiota-Derived Trimethylamine N-Oxide and the Risk of Diabetes: An Updated Systematic Review and Meta-Analysis.","authors":"Sammy Mohammadi, Maysa Eslami, Farzad Pourghazi, Hanieh-Sadat Ejtahed, Ehsan Shahrestanaki, Mostafa Qorbani, Shirin Hasani-Ranjbar, Bagher Larijani","doi":"10.1111/obr.13963","DOIUrl":"https://doi.org/10.1111/obr.13963","url":null,"abstract":"<p><p>Recent studies have discovered higher levels of circulating trimethylamine N-oxide, a metabolite produced by gastrointestinal microbiota, among patients diagnosed with diabetes. This study presents an updated systematic review and meta-analysis examining the association between trimethylamine N-oxide levels and the risk of developing diabetes. PubMed and Scopus databases were searched for the studies published up to April 2024. Observational (cross-sectional, case-control, and cohort) studies examining the relationship between TMAO levels and diabetes were included in our systematic review and meta-analysis, excluding non-original research, non-human studies, and non-English publications. Out of 1538 publications, 32 studies focusing on type 2 and gestational diabetes were included. We conducted two distinct meta-analyses investigating the association between TMAO levels and type 2 diabetes. First, we found significantly elevated TMAO levels in diabetic patients compared to non-diabetics (standardized mean difference [SMD]: 1.21, 95% confidence interval [CI]: 0.13-2.28). Second, we observed that elevated TMAO levels were associated with 49% increased odds of diabetes (odds ratio [OR]: 1.49, 95% CI: 1.06-2.10). However, the pooled hazard ratio (HR) analysis did not reveal a statistically significant association (HR: 1.00, 95% CI: 0.62, 1.61). Moreover, the included studies showed a higher type 2 diabetes prevalence in the elevated TMAO group. Regarding gestational diabetes, we also detected a positive correlation with TMAO levels. Our study indicates that individuals with type 2 diabetes have notably higher TMAO levels compared to non-diabetics. Furthermore, our systematic review suggests an elevated risk of developing both type 2 diabetes and gestational diabetes in individuals with higher TMAO levels.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13963"},"PeriodicalIF":8.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance and Therapeutic Approach Concerning Various Abdominal Adipose Tissue Irregularities in End-Stage Liver Disease","authors":"Qing Liu,&nbsp;Junling Liu,&nbsp;Chao Sun","doi":"10.1111/obr.13955","DOIUrl":"10.1111/obr.13955","url":null,"abstract":"<div>\u0000 \u0000 <p>Accumulating evidence suggests that body mass index is an inaccurate measure of body composition mainly due to its limitation in differentiating distinct compartments in cirrhosis. Adipose tissue, as one of the most important body components, is likely to be misestimated. Cross-sectional imaging using CT or MRI can demonstrate the objective distribution of adipose tissue in patients with end-stage liver disease. CT allows a more precise assessment of adipose tissue and has been increasingly used as a non-invasive metric with substantially predictive and prognostic value. Based on CT, visceral adipose tissue index, subcutaneous adipose tissue index, and the ratio of visceral to subcutaneous adipose tissue area are indicators to measure various adipose tissues. In recent years, the relationship between adipose tissue and prognostication in those populations has been widely investigated, but conclusions remain controversial. Therefore, in this review, we focus on the distribution and function of adipose tissue and seek to define parameters commonly used to measure adipose tissue. We also discuss the association between various indices above mentioned and the development, complications, and mortality of end-stage liver disease in terms of recent data and emerging evidence. Finally, we shed light on potential management against adipose tissue irregularities through nutritional, physical, and pharmacological methods. It is concluded that comprehensive evaluation of fat distribution may help to predict and improve the prognosis of patients with end-stage liver disease.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 10","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Combined Movement Behavior Interventions in Children and Adolescents: A Scoping Review","authors":"Ciaran M. C. Maloney,&nbsp;Andrew J. Atkin,&nbsp;Lee C. Beaumont,&nbsp;Emily Budzynski-Seymour,&nbsp;Victoria E. Warburton","doi":"10.1111/obr.13943","DOIUrl":"10.1111/obr.13943","url":null,"abstract":"<p>Evidence suggests that targeting physical activity, sedentary behavior, and sleep in combination can benefit health and academic outcomes in young people. This scoping review aimed to describe the extent, range, and nature of combined movement behavior interventions and examine recruitment and effectiveness patterns in equity-denied populations. The following electronic databases were searched: Web of Science, CINAHL, MEDLINE, and PsycINFO. Gray literature was identified through ProQuest Dissertations and Theses Global, Google Scholar, and the British Library EThOS. Included studies were randomized or quasi-experimental interventions that modified two or more movement behaviors with the goal of affecting health-, behavioral-, or academic-related outcomes in children or adolescents. Peer-reviewed publications from scientific databases, master's level dissertations, and doctoral theses from gray literature searches in the English language were included. The behavior change technique taxonomy and PROGRESS-Plus framework were used to map intervention characteristics. Thirty studies met the inclusion criteria. Most studies were individual-level randomized controlled trials (40%), conducted in Europe (43%), and delivered in a school setting (77%). Physical activity and sedentary behavior were the predominant behaviors that were modified (83%). The most commonly used behavior change techniques included information about health consequences (67%) and social support [unspecified] (70%). All included studies focused on health-related outcome measures. Ten studies (33%) examined differential effects by PROGRESS-Plus subgroups. Future research should explore the value of movement behavior interventions across the breadth of non-health-related outcomes and include a stronger focus on differential effectiveness across population subgroups.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 10","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13943","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Different Exercise Modes on Inflammatory Markers in Patients With Type 2 Diabetes Mellitus: A Systematic Review With Pairwise and Network Meta-Analyses","authors":"Mousa Khalafi,&nbsp;Aref Habibi Maleki,&nbsp;Michael E. Symonds,&nbsp;Karim Azali Alamdari,&nbsp;Mahsa Ehsanifar,&nbsp;Sara K. Rosenkranz","doi":"10.1111/obr.13954","DOIUrl":"10.1111/obr.13954","url":null,"abstract":"<div>\u0000 \u0000 <p>Exercise training can reduce chronic low-grade inflammation; however, the most effective mode of exercise for lowering inflammation in patients with type 2 diabetes mellitus (T2D) is unknown. Therefore, we performed a systematic review with pairwise and network meta-analyses to determine the efficacy of different modes of exercise training for improving inflammation in patients with T2D. A systematic literature search was conducted in the PubMed, Web of Science, and Scopus from inception to May 2024 using four main key words including “exercise,” “cytokines,” “type 2 diabetes,” and “randomization.” Randomized control or clinical trials investigating the effects of any exercise training mode, including aerobic training (AT), resistance training (RT), AT + RT, high-intensity interval training (HIIT), and HIIT + RT on inflammatory markers including interleukin-6 (IL-6), TNF-α, C-reactive protein (CRP), leptin, or adiponectin in patients with T2D were included. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were calculated using random effects models. Overall, 60 studies involving 3339 patients with T2D were included. Compared to control, exercise training effectively reduced IL-6 [SMD: −0.58], TNF-α [SMD: −0.62], CRP [SMD: −0.78], and leptin [SMD: −0.27], and increased adiponectin [SMD: 0.35]. Based on network meta-analysis, AT reduced IL-6, TNF-α, and leptin and increased adiponectin; and AT + RT reduced IL-6, TNF-α, and CRP, and increased adiponectin. However, RT, HIIT, and HIIT + RT did not change any inflammatory markers as compared with controls. Exercise training is an effective approach for lowering chronic low-grade inflammation in patients with T2D; specifically, AT and AT + RT appear to be more effective than RT, HIIT, or HIIT + RT.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 10","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Missing the Target: A Scoping Review of the Use of Percent Weight Loss for Obesity Management.","authors":"Diana Sherifali, Megan Racey, Donna Fitzpatrick-Lewis, Michelle Greenway, Sanjeev Sockalingam, Jun Wada, Soo Huat Teoh, Ian Patton, David Macklin, Elizabeth F C van Rossum, Luca Busetto, Deborah Bade Horn, J D Patricia Nece, Morgan Emile Gabriel Salmon Leguede, Nicole Pearce, Carel Le Roux, Jamy Ard, Angela S Alberga, Lee Kaplan, Arya M Sharma, Sean Wharton","doi":"10.1111/obr.13960","DOIUrl":"https://doi.org/10.1111/obr.13960","url":null,"abstract":"<p><strong>Introduction: </strong>To co-create comprehensive targets for obesity management, we need to understand the genesis and current use of percent weight loss targets in research. The goals of our scoping review are to (1) synthesize the literature on percent weight loss targets for adults with obesity and (2) discuss the percent weight loss targets in context with their health benefits.</p><p><strong>Methods: </strong>We searched Cochrane, MEDLINE, and EMBASE for English language, pharmaceutical, and/or behavioral intervention studies in adults with obesity where the explicit aim of the study was weight reduction defined as a percent of body weight. Reviewers screened citations and extracted data including study characteristics.</p><p><strong>Results: </strong>From 16,164 abstracts, we included 30 citations which were mostly randomized controlled trials (RCTs) (n = 17) or quasi-experimental studies (n = 12) published between 1992 and 2024. Most of the studies had target weight loss goals between 3% and 10% of body weight (n = 28), while n = 2 had body weight loss goals of 15% or 30%. The proportion of participants who met the percent weight loss target ranged from 5.9% (nutrition only study) to 85% (pharmaceutical study). The studies reported different reasons for targeting a percentage of weight loss such as disease-specific outcomes, reduced risk of disease, or patient-reported outcomes.</p><p><strong>Conclusion: </strong>Percent weight loss targets were based on similar research and were often not feasible nor sustainable for most participants. The design of these interventions and evaluation of obesity management would benefit from more patient-focused parameters which could help to co-design comprehensive targets for research and practice.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13960"},"PeriodicalIF":8.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"A Meta-Analysis of eHealth Interventions to Promote Physical Activity in Young, Middle-Aged, and Late Middle-Aged Adults With Obesity or Overweight\".","authors":"","doi":"10.1111/obr.13959","DOIUrl":"https://doi.org/10.1111/obr.13959","url":null,"abstract":"","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13959"},"PeriodicalIF":8.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Individuals With Overweight and Obesity Have Reduced Affective and Cognitive Empathy? A Systematic Review and Meta-Analysis","authors":"Céline Maupin,&nbsp;Pierre Gerain,&nbsp;Charlotte Dassonneville,&nbsp;Delphine Grynberg","doi":"10.1111/obr.13948","DOIUrl":"10.1111/obr.13948","url":null,"abstract":"&lt;p&gt;The average body mass index (BMI) has been increasing worldwide since 1975, reflecting an increase in the prevalence of overweight and obesity among children, adolescents, and adults; in several countries, these conditions affect more than 80% of the population [&lt;span&gt;1&lt;/span&gt;]. Overweight and obesity are complex and multifactorial conditions characterized by elevated body fat and progressive weight gain, which may be exacerbated throughout life [&lt;span&gt;2&lt;/span&gt;]. In particular, obesity has been recognized as a chronic disease by the World Health Organization (WHO). Among the many diagnostic criteria that can be used to measure excess body weight in adults, BMI, which is calculated as the ratio of weight to height squared (kg/m&lt;sup&gt;2&lt;/sup&gt;), remains the most commonly used. Accordingly, a BMI ranging from 25 to 29.9 kg/m&lt;sup&gt;2&lt;/sup&gt; indicates overweight or preobesity, and a BMI of at least 30 kg/m&lt;sup&gt;2&lt;/sup&gt; indicates obesity [&lt;span&gt;3&lt;/span&gt;]. Overweight and obesity are associated with a greater risk of health complications, such as cardiovascular disease, type 2 diabetes, chronic respiratory disease, nonalcoholic steatohepatitis, and various forms of cancer [&lt;span&gt;4&lt;/span&gt;], all of which can lead to a shorter life expectancy [&lt;span&gt;5, 6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Based on an etiological approach and maintenance models, it is generally suggested that overweight and obesity should be treated with a biopsychosocial approach [&lt;span&gt;2, 7, 8&lt;/span&gt;]. This perspective accounts for that the etiology of these conditions is multifactorial and may be influenced by genetic factors [&lt;span&gt;9-11&lt;/span&gt;], endocrine and neurological factors [&lt;span&gt;12-14&lt;/span&gt;], medical factors [&lt;span&gt;15, 16&lt;/span&gt;], and psychological factors [&lt;span&gt;17-19&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;With respect to psychosocial factors, individuals with obesity are more likely to experience a range of intrapersonal and interpersonal difficulties. For example, they exhibit higher levels of anxiety and depression [&lt;span&gt;20, 21&lt;/span&gt;] and have greater difficulties with emotion regulation [&lt;span&gt;22&lt;/span&gt;]. In particular, individuals with obesity exhibit higher levels of emotional eating than the general population [&lt;span&gt;23&lt;/span&gt;]. There is also a high prevalence of eating disorders among adults with obesity [&lt;span&gt;24, 25&lt;/span&gt;]. Most notably, binge-eating disorder (BED) appears to be strongly associated with obesity. In the general population, the lifetime prevalence of BED is 5.49%, 3.08%, and 1.36% in females with obesity, overweight, and normal weight, respectively; these prevalence rates are slightly lower among males [&lt;span&gt;26&lt;/span&gt;]. Among candidates for prebariatric surgery who present severe obesity, the prevalence rates of BED have been shown to range from 4.2% to 44.5% [&lt;span&gt;27&lt;/span&gt;]. Conversely, 36.2%–87.8% of BED patients will develop obesity in their lifetime [&lt;span&gt;28&lt;/span&gt;]. These findings support the close interplay between obesity and BED.&lt;/p&gt;&lt;p&gt;With respect to interpersonal functioning, individ","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 10","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Pharmacological Interventions in Managing Cardiometabolic Risk Factors in Youth Living with Overweight and Obesity: A Systematic Review and Network Meta-Analysis","authors":"Amir Hossein Faghfouri,&nbsp;Vali Musazadeh,&nbsp;Amin Mokari-Yamchi,&nbsp;Fatemeh Faramarzi,&nbsp;Pedram Pam,&nbsp;Shima Shekari,&nbsp;MohammadHadi Mahmoudzadeh,&nbsp;Shahsanam Gheibi","doi":"10.1111/obr.13946","DOIUrl":"10.1111/obr.13946","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Obesity has become a growing global health concern among young people. This meta-analysis seeks to systematically assess the efficacy and safety of pharmaceutical interventions in improving body weight, body mass index (BMI), waist circumference (WC), diastolic blood pressure (DBP), fasting blood glucose (FBG), and lipid profiles, planned prior to data collection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a comprehensive literature search on PubMed, Scopus, Embase, Web of Science, and the Cochrane Library, covering studies published up to September 2024. Randomized clinical trials (RCTs) were included if they reported efficacy of weight-loss medications in youth populations aged 2–20 years. Direct and indirect evidence were synthesized using a frequentist framework.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pooled analysis on 30 RCTs showed that high dose phentermine/topiramate was more effective in reducing weight (MD: −15.8 kg; 95%CI: −19.17 to −12.43), BMI (MD = −5.35 kg/m2; 95% CI: −8.03, −2.67), WC (MD = −7.69 cm; 95% CI: −10.19, −5.18), and BMI percentile (MD: -20.25; 95%CI: −24.82 to 95% CI: −20.38 to −1.62) compared to placebo. Orlistat (MD = −1.81 mmHg; 95% CI: −2.94, −0.68), metformin (MD: −0.14 unit; 95%CI: −0.23 to −0.04), liraglutide (MD: −11.00 mg/dL; 95% CI: −20.38 to −1.62) were more effective in improving DBP, BMI-z score, and FBG, respectively. Lipid profile and SBP were not affected by studied drugs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>High- and moderate-dose phentermine/topiramate was more effective than a placebo in reducing anthropometric measures in youth living with overweight and obesity. Liraglutide and metformin result in a significant reduction in FBG levels compared to placebo.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 10","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancies Between Recommendations in Evidence-Based Guidelines for the Management of Obesity in Adolescents and Adults: An Evidence Map","authors":"Jana Brauchmann,&nbsp;Luise Laudenbach,&nbsp;Philipp Kapp,&nbsp;Kathrin Grummich,&nbsp;Julia Lischka,&nbsp;Nicole Vanersa,&nbsp;Edrienny Patricia Alves Accioly Rocha,&nbsp;Gundula Ernst,&nbsp;Joerg J. Meerpohl,&nbsp;Antje Tannen,&nbsp;Daniel Weghuber,&nbsp;Susann Weihrauch-Blüher,&nbsp;Susanna Wiegand,&nbsp;Gabriel Torbahn","doi":"10.1111/obr.13945","DOIUrl":"10.1111/obr.13945","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background/Aim</h3>\u0000 \u0000 <p>The aim of this evidence map is to provide a systematic overview of evidence-based guidelines for the management of obesity and to highlight discrepancies between recommendations for the pediatric and adult populations. Knowing about these discrepancies may be relevant during the transition from pediatrics to adult healthcare to enable a structured, successful transfer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used two already existing guideline synopses of <i>the Institute for Quality and Efficiency in Health Care</i> as a basis and additionally searched Embase and Medline as well as guideline portals for creating a systematic overview of evidence-based pediatric and adult guidelines on obesity management. The quality of the identified guidelines was assessed using AGREE II.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-nine guidelines (published 08/2017 to 08/2023), containing 1248 recommendations, were included in the review and allocated to nine different healthcare categories. Discrepancies between the pediatric and adult populations were mainly identified in diagnostics and health behavior lifestyle treatment. Gaps were found in recommendations for bariatric surgery, pharmacotherapy, and emergency (-contraception).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The unique characteristics of adolescence are insufficiently addressed in current evidence-based guidelines. Therefore, healthcare professionals may benefit from considering the discrepancies and gaps identified in this review when providing recommendations during the transition of healthcare for this age group.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 10","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipedema: Progress, Challenges, and the Road Ahead","authors":"Vincenza Cifarelli","doi":"10.1111/obr.13953","DOIUrl":"10.1111/obr.13953","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant physical disability, chronic pain, thromboembolism, and psychosocial distress. Despite its profound impact on women's health and quality of life, lipedema remains underrecognized and insufficiently studied, with an estimated prevalence of approximately 10% among women worldwide. Although the exact etiology of lipedema remains unclear, emerging evidence suggests a multifactorial origin involving genetic predisposition, hormonal influences, and vascular dysfunction—all contributing to its development and progression. Current therapeutic options provide only partial symptom relief and remain noncurative, highlighting the urgent need for expanded research and improved management strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review was conducted to assess the current understanding of lipedema pathophysiology and current treatment options. Research articles were sourced from PubMed, Web of Science, ScienceDirect, and Scopus databases. Over 100 studies were incorporated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This review provides a comprehensive overview of lipedema, encompassing its clinical features, pathophysiological mechanisms, diagnostic challenges, and current treatment modalities. Additionally, the review discusses whether the molecular and metabolic differences between abdominal and femoral AT depots mirror those observed in classical obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Multidisciplinary, research-informed care is essential for managing lipedema, combining conservative therapies, tailored exercise, and liposuction for advanced cases. More research to better understand the underlying pathophysiology is critical to developing targeted treatments, improving diagnostic accuracy, and informing standardized, evidence-based care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 10","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/obr.13953","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}