Knee Extensor Structure and Function in Children, Adolescents, Adults, and Older Adults With Obesity: A Systematic Review and Meta-Analysis

IF 7.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Reviews Pub Date : 2025-05-19 DOI:10.1111/obr.13949

Michael N. Vakula, Youngwook Kim, Eadric Bressel

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引用次数: 0

Abstract

Objective

This study aims to evaluate the association between obesity and both absolute and relative measures of knee extensor muscle structure and contractile function across different age groups, including children, adolescents, adults, and older adults.

Methods

A search for potential studies was performed in four electronic databases. Data were meta-analyzed using a random-effects model for our primary outcomes of knee extensor structure (muscle size and quality) and function (maximal force/torque, rapid torque, and fatigue) and compared between those with or without obesity in each age group.

Results

The findings indicate that obesity significantly increases absolute measures of knee extensor maximal contractile function and muscle size. However, obesity was associated with a decrease in relative measures of maximal and rapid contractile function and muscle quality. The association of obesity with these muscle characteristics varied by age group, with the effects on knee extensor structure and function diminishing with age.

Conclusions

This systematic review and meta-analysis demonstrate that while obesity enhances absolute knee extensor muscle size and maximal force/torque, it detrimentally affects relative muscle function and quality, particularly related to activities of daily living. These effects are less pronounced in older adults, suggesting that age modulates the impact of obesity on muscle structure and function. The findings underscore the importance of interventions targeting the improvement of relative muscle function and quality in individuals with obesity. Further research is necessary to better understand these relationships and to develop more effective intervention strategies for obesity.

Registration

This protocol was prospectively registered in the Open Science Framework (DOI: 10.17605/OSF.IO/ZGUK6).

Abstract Image

查看原文本刊更多论文

儿童、青少年、成人和老年肥胖患者的膝关节伸肌结构和功能：一项系统综述和荟萃分析。

目的：本研究旨在评估肥胖与不同年龄组（包括儿童、青少年、成年人和老年人）膝关节伸肌结构和收缩功能的绝对和相对测量之间的关系。方法：在四个电子数据库中搜索有潜力的研究。使用随机效应模型对数据进行meta分析，以确定我们的膝关节伸肌结构（肌肉大小和质量）和功能（最大力/扭矩、快速扭矩和疲劳）的主要结局，并比较每个年龄组中有无肥胖的数据。结果：肥胖显著增加膝关节伸肌最大收缩功能的绝对测量值和肌肉大小。然而，肥胖与最大和快速收缩功能和肌肉质量的相对测量值下降有关。肥胖与这些肌肉特征的关系因年龄组而异，对膝关节伸肌结构和功能的影响随着年龄的增长而减弱。结论：本系统综述和荟萃分析表明，虽然肥胖增加了绝对膝关节伸肌大小和最大力/扭矩，但它对相对肌肉功能和质量产生不利影响，特别是与日常生活活动相关的肌肉功能和质量。这些影响在老年人中不那么明显，这表明年龄调节了肥胖对肌肉结构和功能的影响。研究结果强调了针对改善肥胖个体相对肌肉功能和质量的干预措施的重要性。进一步的研究是必要的，以更好地了解这些关系，并制定更有效的肥胖干预策略。注册：该协议已在开放科学框架（DOI: 10.17605/OSF.IO/ZGUK6）中前瞻性注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Reviews 医学-内分泌学与代谢

CiteScore

19.30

自引率

1.10%

发文量

130

审稿时长

1 months

期刊介绍： Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.