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Longer-term effects of intermittent fasting on body composition and cardiometabolic health in adults with overweight and obesity: A systematic review and meta-analysis. 间歇性禁食对超重和肥胖成年人身体成分和心脏代谢健康的长期影响:系统回顾和荟萃分析。
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-02-01 Epub Date: 2024-11-05 DOI: 10.1111/obr.13855
Mousa Khalafi, Aref Habibi Maleki, Mahsa Ehsanifar, Michael E Symonds, Sara K Rosenkranz
{"title":"Longer-term effects of intermittent fasting on body composition and cardiometabolic health in adults with overweight and obesity: A systematic review and meta-analysis.","authors":"Mousa Khalafi, Aref Habibi Maleki, Mahsa Ehsanifar, Michael E Symonds, Sara K Rosenkranz","doi":"10.1111/obr.13855","DOIUrl":"10.1111/obr.13855","url":null,"abstract":"<p><p>The aim of the present study was to investigate the effects of long-term intermittent fasting (IF) on body composition and cardiometabolic health in adults with overweight and obesity. PubMed, Web of Science, and Scopus were searched from inception to March 2024 to identify original randomized trials that investigated the effects of IF versus either a control diet (CON) and/or continuous caloric restriction (CR). Participants were adults with overweight and obesity and intervention durations were ≥ 6 months. Overall, a total of 24 studies involving 2032 participants were included in the meta-analysis. Compared with CON, IF significantly reduced body weight [WMD: -2.84 kg], BMI [WMD: -1.41 kg.m<sup>2</sup>], fat mass [WMD: -3.06 kg], fat-free mass [WMD: -0.81 kg], waist circumference [WMD: -3.85 cm], visceral fat [SMD: -0.37], fasting glucose [WMD: -0.14 mmol/l], triglycerides [WMD: -0.12 mmol/l], and diastolic blood pressure [WMD: -2.24 mmHg]. Conversely, IF significantly increased high-density lipoproteins [WMD: 0.04 mmol/l] when compared with CON, but had no effects on insulin, hemoglobin A1c%, total cholesterol, low-density lipoprotein, or systolic blood pressure. Compared with CR, IF significantly reduced fat mass [WMD: -0.70 kg], body fat percentage [WMD: -0.59%], and DBP [WMD: -0.91 mmHg], and increased HDL [WMD: 0.03 mmol/l], with no other significant effects. Subgroup analyses showed that the mode of IF and intervention duration were the primary moderators of IF effects on the markers. In adults with overweight or obesity, IF and CR are comparably effective for reducing body weight and adiposity, as well as for improving cardiometabolic health markers.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13855"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding barriers and facilitators to lifestyle management in people with polycystic ovary syndrome: A mixed method systematic review. 了解多囊卵巢综合征患者生活方式管理的障碍和促进因素:混合方法系统综述。
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-02-01 Epub Date: 2024-10-27 DOI: 10.1111/obr.13854
Margaret McGowan, Rhonda Garad, Girija Wadhwani, Sophia Torkel, Vibhuti Rao, Alison Maunder, Elaine K Osei-Safo, Lisa J Moran, Stephanie Cowan
{"title":"Understanding barriers and facilitators to lifestyle management in people with polycystic ovary syndrome: A mixed method systematic review.","authors":"Margaret McGowan, Rhonda Garad, Girija Wadhwani, Sophia Torkel, Vibhuti Rao, Alison Maunder, Elaine K Osei-Safo, Lisa J Moran, Stephanie Cowan","doi":"10.1111/obr.13854","DOIUrl":"10.1111/obr.13854","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 10-13% of reproductive-aged women. Lifestyle management through diet and physical activity changes can improve reproductive, metabolic, and psychological comorbidities. The aim of this systematic review is to understand the barriers and facilitators to lifestyle changes from the perspective of people with PCOS and health care professionals (HCP) using the theoretical domains framework and capability, opportunity, motivation, and behavior model. Six databases were systematically searched for qualitative, quantitative, and mixed-methods studies to 22nd September 2022. Quantitative outcomes from quantitative and mixed-methods studies were narratively synthesized and all studies were thematically analyzed. Sixty-eight papers met the eligibility criteria. HCP education on lifestyle management in PCOS was viewed by all to be inadequate, impacting the quality of care and health outcomes. Lifestyle advice delivered by a multidisciplinary team, including dietitians, was identified as a key component for change. All agreed that there was a need for individualized and PCOS-specific lifestyle advice. Weight stigma was identified as negatively impacting both those in larger and smaller bodies with PCOS, reducing the quality of care and affecting self-perception and mental health. People with PCOS perceived that lifestyle management was overly focused on weight loss and fertility, independent of their own personal motivations and goals. Systemic changes, including increasing HCP education on lifestyle management and multidisciplinary collaboration, focusing on lifestyle advice that meets individual needs, and reducing the use of weight-centric care are necessary for long-term sustainable changes and improvements in health outcomes in people with PCOS.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13854"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary calcium intake in relation to metabolic syndrome in adults: A systematic review and dose-response meta-analysis of epidemiological studies with GRADE assessment. 膳食钙摄入量与成人代谢综合征的关系:通过 GRADE 评估对流行病学研究进行系统回顾和剂量反应荟萃分析。
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-02-01 Epub Date: 2024-10-08 DOI: 10.1111/obr.13850
Roxana Nematbakhsh, Parisa Rouhani, Parvane Saneei
{"title":"Dietary calcium intake in relation to metabolic syndrome in adults: A systematic review and dose-response meta-analysis of epidemiological studies with GRADE assessment.","authors":"Roxana Nematbakhsh, Parisa Rouhani, Parvane Saneei","doi":"10.1111/obr.13850","DOIUrl":"10.1111/obr.13850","url":null,"abstract":"<p><p>Numerous studies have examined the relationship of calcium intake and metabolic syndrome (MetS) in adults in previous decades; but the results were inconsistent across different societies. This systematic review and dose-response meta-analysis assessed the relation between calcium consumption and MetS in adults. We did a systematic search of all articles published up to July 2023 in Scopus, PubMed/Medline, ISI Web of Science electronic databases, and Google Scholar. Observational studies investigated the association between dietary calcium (Ca) intake and MetS in adults were eligible to be included. For computing the estimates, a random effects model was applied. Combining 24 effect size from 17 investigations (15 cross-sectional and two cohort studies) with 74,720 participants and 18,200 cases showed that highest versus lowest level of dietary Ca intake was related to 23% significant decreased odds of MetS (OR = 0.77; 95% CI: 0.66, 0.89). Linear dose-response analysis of estimates from 12 investigations showed that each 100 mg/day increment in dietary Ca intake was associated with 3% marginally significant decreased odds in MetS (OR = 0.97; 95%CI: 0.93, 1.01). In nonlinear dose-response analysis of 12 studies with 67,896 participants, a significant association between dietary calcium intake and MetS was found (P<sub>nonlinearity</sub> <0.001); such that 500 mg/day dietary calcium intake was related to maximum decrease in odds of MetS. According to this meta-analysis, the likelihood of MetS was significantly lower in adults with higher level of dietary calcium intake. Further large-scale prospective cohort investigations are needed to obtain stronger and more accurate results.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13850"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of stevia consumption on appetite in adults: A systematic review and dose-response meta-analysis of randomized controlled trials.
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-01-30 DOI: 10.1111/obr.13902
Marzieh Zare, Mobina Zeinalabedini, Soraiya Ebrahimpour-Koujan, Leila Azadbakht
{"title":"Effects of stevia consumption on appetite in adults: A systematic review and dose-response meta-analysis of randomized controlled trials.","authors":"Marzieh Zare, Mobina Zeinalabedini, Soraiya Ebrahimpour-Koujan, Leila Azadbakht","doi":"10.1111/obr.13902","DOIUrl":"https://doi.org/10.1111/obr.13902","url":null,"abstract":"<p><p>Stevia is an intense, calorie-free sweetener that is frequently used to reduce energy intake; however, studies examining its effects on appetite and energy intake have produced mixed results, indicating that a definitive consensus has not yet been reached. This systematic review and meta-analysis aimed to determine the impact of stevia on appetite and energy intake in adults. The PROSPERO registration number for this research is CRD42023414411. The databases PubMed (MEDLINE), Scopus, Web of Science, and Google Scholar were systematically searched. In addition, the reference lists of extracted articles and pertinent reviews were examined. Two evaluators performed screening, quality assessment, and data extraction independently. Furthermore, the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach was employed to systematically assess the certainty level of the evidence presented in our study. Eleven clinical trials with a total of 428 participants were included. We found no significant changes in any appetite scores following stevia consumption (very low to moderate certainty of the evidence). Moreover, subgroup analyses demonstrated the scores of desires to eat increased significantly in the oral intake of stevia and not enteral intake subgroup (WMD: 0.45; 95% CI: 0.009, 0.89; P = 0.046). In addition, the number of studies reporting energy intake was limited, preventing a meta-analysis of this variable. In conclusion, stevia consumption has no significant effect on appetite scores in adults but it seems that more long-term clinical trials are needed to obtain more accurate results. PRACTITIONER POINT: Stevia, as a non-nutritive sweetener, has no significant effect on appetite scores in adults.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13902"},"PeriodicalIF":8.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A best practice guide for conducting healthy food retail research: A resource for researchers and health promotion practitioners.
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-01-29 DOI: 10.1111/obr.13870
Tailane Scapin, Tara Boelsen-Robinson, Shaan Naughton, Jaithri Ananthapavan, Miranda Blake, Megan Ferguson, Clara Gomez-Donoso, Adyya Gupta, Victoria Hobbs, Emma Joy McMahon, Helena Romaniuk, Gary Sacks, Julia Thompson, Laura Alston, Kathryn Backholer, Rebecca Bennett, Julie Brimblecombe, Jasmine Chan, Katrine S Duus, Oliver Huse, Damian Maganja, Josephine Marshall, Liliana Orellana, Emalie Rosewarne, Sally Schultz, Katherine Sievert, Simone Sherriff, Huong Ngoc Quynh Tran, Carmen Vargas, Jason H Y Wu, Anna Peeters, Adrian J Cameron
{"title":"A best practice guide for conducting healthy food retail research: A resource for researchers and health promotion practitioners.","authors":"Tailane Scapin, Tara Boelsen-Robinson, Shaan Naughton, Jaithri Ananthapavan, Miranda Blake, Megan Ferguson, Clara Gomez-Donoso, Adyya Gupta, Victoria Hobbs, Emma Joy McMahon, Helena Romaniuk, Gary Sacks, Julia Thompson, Laura Alston, Kathryn Backholer, Rebecca Bennett, Julie Brimblecombe, Jasmine Chan, Katrine S Duus, Oliver Huse, Damian Maganja, Josephine Marshall, Liliana Orellana, Emalie Rosewarne, Sally Schultz, Katherine Sievert, Simone Sherriff, Huong Ngoc Quynh Tran, Carmen Vargas, Jason H Y Wu, Anna Peeters, Adrian J Cameron","doi":"10.1111/obr.13870","DOIUrl":"https://doi.org/10.1111/obr.13870","url":null,"abstract":"<p><p>Retail food environments play a pivotal role in influencing dietary behaviors, and therefore have huge potential as settings for promoting good nutrition and preventing obesity. Conducting research in retail settings can be challenging due to the varied motivations of the parties involved and the complex nature of retail environments. To improve the quality and consistency of research in this field, we have identified 16 thematic topics aimed at guiding researchers and public health practitioners on how to conduct healthy food retail research. A summary for each topic, encompassing existing methodologies, best practice examples, and knowledge gaps, was developed based on available literature and the collective experience and expertise of 32 multidisciplinary researchers from a high-income perspective engaged in healthy food retail research in a diverse range of retail settings. A summary checklist describing key considerations at each stage of conducting healthy food retail research was also developed.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13870"},"PeriodicalIF":8.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plant-based and sustainable diet: A systematic review of its impact on obesity.
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-01-29 DOI: 10.1111/obr.13901
Sara P Mambrini, Claudia Penzavecchia, Francesca Menichetti, Andrea Foppiani, Alessandro Leone, Marta Pellizzari, Federica Sileo, Alberto Battezzati, Simona Bertoli, Ramona De Amicis
{"title":"Plant-based and sustainable diet: A systematic review of its impact on obesity.","authors":"Sara P Mambrini, Claudia Penzavecchia, Francesca Menichetti, Andrea Foppiani, Alessandro Leone, Marta Pellizzari, Federica Sileo, Alberto Battezzati, Simona Bertoli, Ramona De Amicis","doi":"10.1111/obr.13901","DOIUrl":"https://doi.org/10.1111/obr.13901","url":null,"abstract":"<p><p>The food system significantly affects the environment through land use, emissions from livestock, deforestation, and food waste. Diet sustainability considers the environmental effects of food production, distribution, and consumption. Animal products emit more greenhouse gases than plant-based foods, prompting a shift towards plant-focused diets for reduced emissions. Sustainable diets, like the EAT-Lancet model, prioritize plant-based foods, adjusting for regional eating habits. These diets aim to be both environmentally friendly and conducive to human health, addressing concerns like obesity and chronic diseases. Obesity is a major global health challenge, and its complex relationship with food production and consumption patterns calls for sustainable solutions to reduce pressure on ecosystems and promote healthier lifestyles. Tackling obesity requires holistic strategies that address not only individual health but also the broader environmental impacts of food systems. A systematic review examined the link between plant-based diets and obesity focusing on studies assessing Body Mass Index (BMI) and body fat assessment. Despite limited research, evidence suggests that adherence to a plant-based diet, particularly a healthy one, is associated with lower obesity rates. More longitudinal and intervention studies are necessary for a stronger consensus on the matter.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13901"},"PeriodicalIF":8.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the progress and trends of immunotherapy for type 1 diabetes: A comprehensive bibliometric analysis spanning nearly two decades.
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-01-28 DOI: 10.1111/obr.13888
Yixin Jiang, Zhou Xu, Yuting Wu, Xinglei Li, Jitao Ling, Yixuan Chen, Zicheng Zhu, Pingping Yang, Xiao Liu, Deju Zhang, Jianping Liu, Xiaoping Yin, Jing Zhang, Peng Yu
{"title":"Exploring the progress and trends of immunotherapy for type 1 diabetes: A comprehensive bibliometric analysis spanning nearly two decades.","authors":"Yixin Jiang, Zhou Xu, Yuting Wu, Xinglei Li, Jitao Ling, Yixuan Chen, Zicheng Zhu, Pingping Yang, Xiao Liu, Deju Zhang, Jianping Liu, Xiaoping Yin, Jing Zhang, Peng Yu","doi":"10.1111/obr.13888","DOIUrl":"https://doi.org/10.1111/obr.13888","url":null,"abstract":"<p><strong>Introduction: </strong>Immunotherapy is a crucial treatment for type 1 diabetes (T1D), yet analyses focusing on research priorities and trends in this field are limited. Therefore, this study employs bibliometric methods to systematically explore the current research status of immunotherapy for T1D.</p><p><strong>Methods: </strong>Based on the Web of Science Core Collection Database, 1573 articles and review articles related to immunotherapy for T1D published from 2004 to 2023 were screened for bibliometric analysis. VOSviewer, CiteSpace, and R software were applied to comprehensively analyze the number of publications, journals, countries, authors, institutions, keywords, and references.</p><p><strong>Results: </strong>In the past two decades, the global annual publication rate has seen a significant increase of 238.24%. Almost 40% of all publications have appeared in the last 5 years, accounting for over 50% of total citations. Journals such as Diabetes, Journal of Autoimmunity and Frontiers in Immunology have exerted substantial influence. Collaboration across nations has been notably strong, with the United States leading the way. The University of Florida is the most productive institution. Terms like \"nivolumab,\" \"ipilimumab,\" \"pembrolizumab,\" and \"immune checkpoint inhibitor(s)\" gain considerable traction. The majority of research has clustered around themes such as immunomodulation, autoimmune diseases, immune checkpoint inhibitors, mesenchymal stem cells, and cell therapy. Precision medicine, immune checkpoint inhibitors, and nanotechnology are trending focal points in contemporary research.</p><p><strong>Conclusion: </strong>The outcomes of the study are instrumental in enabling scholars to comprehend the evolving trajectory of immunotherapeutic approaches for T1D and facilitate the swift recognition of emerging research pathways.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13888"},"PeriodicalIF":8.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional and functional outcomes in trials of nutrient-stimulated hormone-based therapy-A systematic mapping review.
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-01-27 DOI: 10.1111/obr.13890
Sébastien Czernichow, Nathalie Rassy, Claire Carette, Nicholas Shoung, Frank B Hu, Claire Rives-Lange
{"title":"Nutritional and functional outcomes in trials of nutrient-stimulated hormone-based therapy-A systematic mapping review.","authors":"Sébastien Czernichow, Nathalie Rassy, Claire Carette, Nicholas Shoung, Frank B Hu, Claire Rives-Lange","doi":"10.1111/obr.13890","DOIUrl":"https://doi.org/10.1111/obr.13890","url":null,"abstract":"<p><strong>Introduction: </strong>Currently, trials are investigating the efficacy of nutrient-stimulated hormone-based therapies (NuSHs) in promoting weight loss in people living with overweight and obesity. However, the extent to which nutritional and functional outcomes are evaluated remains uncertain. Thus, we conducted a systematic mapping to assess the presence of nutritional and functional outcomes in randomized controlled trials (RCTs) investigating NuSHs.</p><p><strong>Methods: </strong>We conducted a systematic mapping search on the Cochrane Central Register of Controlled Trials (CENTRAL), which includes ClinicalTrials.gov and the International Clinical Trials Registry Platform for interventional trials of NuSHs registered from inception to December 31, 2023. We excluded non- and quasi-randomized trials, phase I trials, trials that did not include body weight as a primary or secondary outcome, trials with an intervention duration of less than 6 months, and trials that did not specify a body mass index threshold in their eligibility criteria. Outcomes included: dietary intake, eating behavior, body composition, physical performance, muscle strength, bone health, and levels of vitamins, trace elements, albumin, prealbumin, and hemoglobin.</p><p><strong>Results: </strong>The search identified 2284 trials, of which 417 were included in the analysis. The proportion of RCTs that included nutritional assessment other than body weight increased over time. Approximately, 20.4% reported measurements of body composition, 17.3% reported measurements of albumin/prealbumin/hemoglobin, and 17% reported assessment of dietary intake and eating behavior. Evaluations of bone health, physical performance, muscle strength, and measurements of vitamins/trace elements were reported in less than 5% of the total trials each.</p><p><strong>Conclusion: </strong>The present review has shown the sparse reporting of nutritional and functional outcomes in RCTs evaluating the impact of NuSHs.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13890"},"PeriodicalIF":8.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of stem cell-derived somatic cells to treat metabolic dysfunction-associated steatotic liver disease and diabetes.
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-01-24 DOI: 10.1111/obr.13899
Eduardo H Gilglioni, Mayank Bansal, Wadsen St-Pierre-Wijckmans, Stephanie Talamantes, Alvile Kasarinaite, David C Hay, Esteban N Gurzov
{"title":"Therapeutic potential of stem cell-derived somatic cells to treat metabolic dysfunction-associated steatotic liver disease and diabetes.","authors":"Eduardo H Gilglioni, Mayank Bansal, Wadsen St-Pierre-Wijckmans, Stephanie Talamantes, Alvile Kasarinaite, David C Hay, Esteban N Gurzov","doi":"10.1111/obr.13899","DOIUrl":"https://doi.org/10.1111/obr.13899","url":null,"abstract":"<p><p>Developments in basic stem cell biology have paved the way for technology translation in human medicine. An exciting prospective use of stem cells is the ex vivo generation of hepatic and pancreatic endocrine cells for biomedical applications. This includes creating novel models 'in a dish' and developing therapeutic strategies for complex diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD) and diabetes. In this review, we explore recent advances in the generation of stem cell-derived hepatocyte-like cells and insulin-producing β-like cells. We cover the different differentiation strategies, new discoveries, and the caveats that still exist regarding their routine use. Finally, we discuss the challenges and limitations of stem cell-derived therapies as a clinical strategy to manage metabolic diseases in humans.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13899"},"PeriodicalIF":8.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity of non-traditional measures of obesity compared to total body fat across the life course: A systematic review and meta-analysis.
IF 8 2区 医学
Obesity Reviews Pub Date : 2025-01-24 DOI: 10.1111/obr.13894
Alexandra M Palumbo, Chandni Maria Jacob, Sahar Khademioore, Mohammad Nazmus Sakib, Yulika Yoshida-Montezuma, Nicolette Christodoulakis, Peter Yassa, Manasvi Sai Vanama, Syrine Gamra, Pei-Ju Ho, Ritu Sadana, Vanessa De Rubeis, Lauren E Griffith, Laura N Anderson
{"title":"Validity of non-traditional measures of obesity compared to total body fat across the life course: A systematic review and meta-analysis.","authors":"Alexandra M Palumbo, Chandni Maria Jacob, Sahar Khademioore, Mohammad Nazmus Sakib, Yulika Yoshida-Montezuma, Nicolette Christodoulakis, Peter Yassa, Manasvi Sai Vanama, Syrine Gamra, Pei-Ju Ho, Ritu Sadana, Vanessa De Rubeis, Lauren E Griffith, Laura N Anderson","doi":"10.1111/obr.13894","DOIUrl":"https://doi.org/10.1111/obr.13894","url":null,"abstract":"<p><p>IntroductionTraditional obesity measures including body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio have limitations. The primary objective of this study was to identify and review the validity of non-traditional obesity measures, using measures of total body fat as the reference standard, that have been used across multiple life stages. MethodsWe conducted a systematic review and searched MEDLINE, Embase, and PsycINFO. We included observational studies published from 2013 to October 2023 among \"the general population\" for any life stage that reported the validity of non-traditional obesity measures compared to total body fat reference standards. Separate meta-analyses were performed to pool correlation coefficients and mean differences for non-traditional obesity measures that were evaluated at multiple life stages. ResultsA total of 123 studies were included, and 55 validated non-traditional obesity measures were identified. Of these, 13 were evaluated at multiple life stages. Two-dimensional (2D) digital imaging technologies, three-dimensional (3D) body scanners, relative fat mass (RFM), and mid-upper arm circumference had high or moderate validity (pooled correlation coefficient >0.70). Pooled mean differences were small (<6%) between total body fat percentage from reference standards and from RFM, 2D digital imaging technologies, 3D body scanners, and the body adiposity index. Heterogeneity (I<sup>2</sup>) was >75% in most meta-analyses. ConclusionNumerous validated non-traditional obesity measures were identified; relatively few were evaluated at multiple life stages and did not consider health risks associated with adiposity. More research is needed to define valid obesity measures across all life stages that assess health and adiposity.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13894"},"PeriodicalIF":8.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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