Obesity Reviews最新文献

{"title":"Impact of food, beverage, and alcohol brand marketing on consumptive behaviors and health in children and adults: A systematic review and meta-analysis.","authors":"Emma Boyland, Nicholas Davies, Moon Wilton, Andrew Jones, Michelle Maden, Ffion Curtis, Rebecca Evans, Amy Finlay, Lauren McGale, Caroline Cerny, Nika Pajda, Abigail K Rose","doi":"10.1111/obr.13932","DOIUrl":"https://doi.org/10.1111/obr.13932","url":null,"abstract":"<p><p>Exposure to unhealthy food, beverage, and alcohol marketing can contribute to inadequate diet and excess alcohol consumption, both risk factors for diet-related non-communicable diseases including obesity and cancer. By not featuring specific products, brand-only marketing strategies circumvent restrictions that assess healthiness at the product level and restrict accordingly. Currently, there is no global or national government policy that explicitly addresses brand marketing for unhealthy products linked to diet-related non-communicable diseases. This systematic review and meta-analysis synthesizes contemporary evidence on the effects of food, beverage, and alcohol brand-marketing on diet-related cognitive outcomes (preference, choice), diet-related behavioral outcomes (purchase requests, purchase, consumption), and health-related outcomes (body weight, body mass index, obesity) in children and adults. Included studies manipulated acute marketing exposure, with at least one brand-only marketing condition. Fourteen databases were searched (including MEDLINE and PubMed) for articles published from January 2004 to February 2024. Nineteen eligible studies were identified and assessed for bias; five were included in the meta-analysis assessing effects on consumption. Findings from the review suggest brand marketing for food, beverages, and alcohol can influence preference, choice, and purchase intent. The meta-analysis found no evidence of a significant effect of brand-only marketing on consumption. Overall, evidence was limited and of mixed quality so further robust research is needed to inform regulatory action. Government policies for reducing brand-only marketing are needed to protect vulnerable populations from brand marketing promoting unhealthy consumption behaviors that increase the risk of non-communicable disease.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13932"},"PeriodicalIF":8.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms at short-, medium-, and long-term follow-up after bariatric surgical procedures: A systematic review and meta-analysis.","authors":"Alyssa J Budin, Wendy A Brown, Andrew D MacCormick, Ian Caterson, Priya Sumithran","doi":"10.1111/obr.13927","DOIUrl":"https://doi.org/10.1111/obr.13927","url":null,"abstract":"<p><strong>Importance: </strong>Patients experience both positive and negative changes in mood following bariatric surgery and mental health outcomes have been reported to differ between procedure types. Understanding changes in symptoms over time and between surgical procedures is vital to providing meaningful, long-term, patient-centered care.</p><p><strong>Objective: </strong>To examine the nature and time course of changes in depressive symptoms after different bariatric procedures.</p><p><strong>Evidence review: </strong>Medline, Embase, Emcare, PsycINFO, CINAHL, and CENTRAL databases were systematically searched from inception to January 18, 2024. Ninety publications describing patient-reported depressive symptoms in 13,146 individuals undergoing bariatric procedures were included.</p><p><strong>Findings: </strong>Qualitative analysis indicated a reduction of depressive symptoms at all time points following all bariatric procedure types. However, a subset of patients experienced worsening symptoms post-surgery. Meta-analyses indicated depressive symptoms improve following bariatric surgery by an SMD of -0.6 (95% CI: -0.8, -0.4) in the short term (0-4 months post-surgery), -0.9 (95% CI: -1.0, -0.8) in the medium term (5-12 months), and -0.7 (95% CI: -0.9, -0.5) in the long term (> 12 months). There was no evidence that surgery type was associated with the change in depressive symptoms at any time point post-surgery.</p><p><strong>Conclusions and relevance: </strong>Patient-reported depressive symptoms improve following bariatric surgery with improvements peaking in the medium term and diminishing over time. Significant heterogeneity in the results cannot be explained by surgery type, baseline depression, or depression instrument used across studies. Long-term management of post-bariatric surgery patients must consider the potential for adverse psychological effects of surgery.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13927"},"PeriodicalIF":8.0,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryolipolysis and associated health outcomes, adverse events, and satisfaction: A systematic review and meta-analysis.","authors":"Roshan Ravindran, Damiano Pizzol, Masoud Rahmati, Susanna Caminada, Dong Keon Yon, Jae Il Shin, Nicola Veronese, Pinar Soysal, Guillaume Fond, Laurent Boyer, José Francisco López-Gil, Karel Kostev, Julia Gawronska, Lee Smith","doi":"10.1111/obr.13925","DOIUrl":"https://doi.org/10.1111/obr.13925","url":null,"abstract":"<p><strong>Background: </strong>Cryolipolysis is a nonsurgical adiposity reduction treatment that is increasing in popularity globally. The aim of this paper was to carry out a systematic review with meta-analysis on cryolipolysis and associated health outcomes, adverse events (AE) and patient satisfaction.</p><p><strong>Methods: </strong>Major databases were searched from inception until April 4, 2024. Meta-analysis was performed using random-effect models to calculate the pooled effects size and 95% confidence interval (CI) of each finding. The systematic review protocol was registered on PROSPERO, CRD-42024548077.</p><p><strong>Results: </strong>A total of 30 studies were included, including 3158 participants. The result of meta-analyses showed reduced body mass index (mean differences [MD] = -1.80, 95% confidence interval [CI] -2.98, -0.62, p = 0.0003), waist-to-hip ratio (MD = -0.09, 95% CI -0.16, -0.02, p = 0.001), mean abdominal circumference (cm) (MD = -3.56, 95% CI -4.98, -2.15, p = 0.000001), and mean suprailiac fat thickness (FT) (mm) (MD = -5.22, 95% CI -9.03, -1.42, p = 0.0007), 12 weeks after cryolipolysis as compared with baseline values. The satisfaction rate was 80.4% and the AE of cryolipolysis was 49.5% for numbness, 44.5% for erythema, 30.5% for edema, 28.8% for pain, 25.4% for sensitivity, 15.2% for tingling, and 2% for hyperpigmentation.</p><p><strong>Conclusion: </strong>In the present study, it was found that cryolipolysis was associated with a reduction in the number of adiposity parameters at 3 months follow-up. A relatively high level of minor AEs was reported; however, patient satisfaction was high suggesting that the treatment is well tolerated.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13925"},"PeriodicalIF":8.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic determinants of overweight and obesity among Mexican children and adolescents: Systematic review and meta-analysis.","authors":"Magaly Aceves-Martins, Yareni Yunuen Gutierrez-Gómez, Carlos Francisco Moreno-García","doi":"10.1111/obr.13926","DOIUrl":"https://doi.org/10.1111/obr.13926","url":null,"abstract":"<p><p>Socioeconomic status (SES) has widely been studied as a potential risk factor for obesity among children and adolescents. Nevertheless, SES determinants are rarely contextualized within a country's situation. This work aimed to identify SES factors associated with childhood and adolescent obesity in Mexico. Eleven scientific databases were searched, and 54 studies met the inclusion criteria. When measuring SES, 56% of the studies measured wealth, 50% living environment (urban vs rural areas), 44% parental education, 30% ethnic origin, 24% income or monetary measurements, 20% parental occupation and 18% the type of school participants attended. We found that Mexican children and adolescents were significantly more likely to have either overweight or obesity if they had a higher wealth (estimated through household characteristics) (OR 1.43, 95% CI 1.19, 1.72), lived in urban areas (OR 1.41, 95% CI 1.20, 1.66), identified as non-Indigenous (OR 1.55, 95% CI 1.22, 1.96), had mothers with secondary school studies or higher (OR 1.44, 95% CI 1.14, 1.82), or mothers who were employed (OR 1.39, 95% CI 1.30, 1.48). Not all indicators of a higher SES (e.g., attending private school or not participating in a food provision program) were significantly associated with childhood overweight or obesity in Mexico. Furthermore, the evidence for other indicators, such as family structure, family size, household income, and monetary measures, remains uncertain. This work presents evidence of childhood obesity inequalities in Mexico.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13926"},"PeriodicalIF":8.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of different revisional surgeries after sleeve gastrectomy: A network meta-analysis.","authors":"Piotr Małczak, Sung Ryul Shim, Michał Wysocki, Justyna Rymarowicz, Mateusz Wierdak, Michał Pędziwiatr, Piotr Major","doi":"10.1111/obr.13930","DOIUrl":"https://doi.org/10.1111/obr.13930","url":null,"abstract":"<p><p>IntroductionSleeve gastrectomy (SG) is the most commonly performed bariatric surgery worldwide. Despite its effectiveness, over 20% of patients require revisional surgery due to weight regain, insufficient weight loss, or complications such as gastroesophageal reflux disease (GERD). Various revisional bariatric procedures are available. This study aims to systematically compare the efficacy and safety of these revisional procedures following failed SG. MethodsThis systematic review and network meta-analysis (NMA) adhered to PRISMA guidelines. A comprehensive literature search was conducted until May 2024. Studies comparing at least two bariatric surgeries for revisions after SG were included. Data on total weight loss percentage (%TWL), excess weight loss percentage (%EWL), and morbidity rates were extracted. Bayesian NMA was performed using the \"gemtc\" package in R software. Outcomes were assessed using mean differences (MD) and odds ratios (OR) with 95% credible intervals (CrI). ResultsTwenty-three studies involving 3266 participants were included. In %EWL, SADI-S (MD 14.80; 95% CrI: 5.38, 24.40) and OAGB (MD 8.28; 95% CrI: 1.99, 14.30) were significantly more effective. In %TWL, SADI-S (MD 9.27; 95% CrI: 1.06, 17.8) showed superior outcomes. No significant differences in morbidity rates were observed among the revisions. SUCRA analysis ranked SADI-S highest for both %EWL and %TWL, and re-LSG as the best choice in regards to morbidity. ConclusionSingle anastomosis duodeno-ileal bypass with sleeve (SADI-S) is the preferred revisional procedure following sleeve gastrectomy due to superior weight loss outcomes and comparable complication rates. Further randomized controlled trials are needed to confirm these findings.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13930"},"PeriodicalIF":8.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise training in metabolic and bariatric surgery: An overview of systematic reviews.","authors":"Julia Hussien, Marine Asselin, Dale Bond, Yin Wu, Valentina Ly, David Creel, Pavlos Papasavas, Bret H Goodpaster, Aurélie Baillot","doi":"10.1111/obr.13920","DOIUrl":"https://doi.org/10.1111/obr.13920","url":null,"abstract":"<p><p>Understanding how to incorporate exercise into metabolic and bariatric surgery programs to optimize treatment outcomes is of great interest, as evidenced by 11 reviews published on this topic in 2022 alone. This overview of reviews was conducted to create a single cohesive resource to aid clinicians and researchers by exploring the effects of pre- and post-operative exercise training on health outcomes. A literature search of 7 electronic databases was performed (updated 09/2023) and 24 reviews met preset PICOS eligibility criteria and were included: 4 exploring preoperative exercise training, 13 postoperative, and 7 both. Comparing reviews, outcome results were organized as concordant, discordant, or inconclusive, and then categorized into \"what we currently know\", \"what we think we know\" and \"what we still don't know\". We do not currently know the effects of pre- or post-operative exercise training on any outcomes, but we think we know that preoperative exercise training has a positive effect on BMI and 6-minute walking test distance, and postoperative exercise training has a positive effect on body weight and BMI, waist circumference, bone mineral density, 6-minute walking test distance, muscle strength, and systolic blood pressure. Despite the abundance of research, much still needs to be done in terms of enhancing methodological rigor and reporting to achieve greater confidence in our conclusions; recommendations for the next research steps are made.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13920"},"PeriodicalIF":8.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discontinuing glucagon-like peptide-1 receptor agonists and body habitus: A systematic review and meta-analysis.","authors":"Sara Berg, Hannah Stickle, Suzanne J Rose, Eric C Nemec","doi":"10.1111/obr.13929","DOIUrl":"https://doi.org/10.1111/obr.13929","url":null,"abstract":"<p><p>Research on Glucagon-like peptide 1 receptor agonist (GLP-1RA) has mainly focused on the efficacy of weight loss and not the long-term efficacy of weight loss maintenance. This systematic review and meta-analysis aims to evaluate the sustainability of weight loss of patients taking GLP-1RAs following the discontinuation of the drug. EBSCOhost was used to simultaneously search Academic Search Premier, CINHAL Ultimate, Cochrane Central Register of Controlled Trials, MEDLINE with full text, Cochrane Database of Systematic Reviews, and separate PubMed search was systematically investigated using a predetermined search strategy from inception to February 1st, 2024. The authors extracted data regarding body weight change from baseline on treatment and off treatment, change in waist circumference from baseline on and off treatment, and change in BMI from baseline on and off treatment. Meta-analysis was conducted using RevMan (version 5.4) to calculate pooled mean differences using a Der Simonian-Laird Random Effects model. ResultsThe initial search yielded 497 relevant articles and, after screening, retained 8 randomized controlled trials comprised of 2372 participants, all with a BMI ≥ 27 kg/m². After discontinuing GLP-1RA therapy, weight regain was proportional to the original weight loss. Participants who took liraglutide regained 2.20 kg (95% CI 1.69 to 2.70, P < 0.00001), and participants taking semaglutide/tirzepatide regained 9.69 kg (95% CI 5.78 to 13.60, P < 0.00001). This systematic review and meta-analysis show that significant weight is regained after discontinuing GLP-1RA treatment, which should be discussed when stopping therapy. PRACTITIONER POINTS: Question: Does discontinuation of Glucagon-like peptide 1 receptor agonist (GLP-1RA) treatment lead to significant weight gain? Findings: In this systematic review and meta-analysis, discontinuing GLP-1RA treatment led to a pooled overall mean weight regain of 2.20 kg in participants taking liraglutide and 9.69 kg in those patients prescribed semaglutide/tirzepatide. The proportion of weight regained was proportional to the amount originally lost. Meaning: Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to obesity.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13929"},"PeriodicalIF":8.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperphagia in Bardet-Biedl syndrome: Pathophysiology, burden, and management.","authors":"Philip L Beales, Metin Cetiner, Andrea M Haqq, Jennifer Miller, Ashley H Shoemaker, Diana Valverde, Miriam Zacchia, Hélène Dollfus","doi":"10.1111/obr.13915","DOIUrl":"https://doi.org/10.1111/obr.13915","url":null,"abstract":"<p><p>Bardet-Biedl syndrome (BBS) is a rare, genetically heterogeneous, and highly pleiotropic autosomal recessive ciliopathy. Patients typically present with early loss of vision, hyperphagia, severe obesity, learning difficulties, and renal dysfunction. In patients with BBS, dysfunction of the immotile primary cilia in the hypothalamic melanocortin-4 receptor (MC4R) pathway responsible for controlling energy balance, hunger, and satiety results in severe hyperphagia manifesting in food-seeking behaviors that drive the development of obesity early in childhood. These behaviors have negative impacts on many areas of the lives of patients with BBS and their families/caregivers, including sleep, mood, school/work, and social/family relationships. Additionally, many patients feel stigmatized due to their hyperphagia-associated food-seeking behaviors and the resulting obesity, which exacerbates the impacts of hyperphagia on quality of life. Early identification and management of hyperphagia in patients with BBS is key: mitigating food-seeking and weight gain can improve quality of life and reduce the risk of metabolic and cardiovascular diseases that is increased in patients with BBS. Until recently, the only treatment strategies available were lifestyle and diet modifications. However, targeted treatment with the novel MC4R agonist setmelanotide now offers an effective management option to reduce hyperphagia and weight in patients with BBS, improving overall health and quality of life.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13915"},"PeriodicalIF":8.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transabdominal photobiomodulation applications: A systematic review and meta-analysis.","authors":"Ana M Jiménez-García, Candela Zorzo, Alba Gutiérrez-Menéndez, Jorge L Arias, Natalia Arias","doi":"10.1111/obr.13921","DOIUrl":"https://doi.org/10.1111/obr.13921","url":null,"abstract":"<p><strong>Introduction: </strong>The escalating prevalence of obesity presents a multifaceted challenge involving genetic, environmental, and behavioral factors, with significant public health implications. Photobiomodulation (PBM) may positively influence metabolic activities in adipose cells and regulate inflammation, potentially impacting obesity.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted to assess the effects of transabdominal PBM treatments in preclinical and clinical obesity studies, covering a range of physical, psychological, and physiological variables. Research articles were sourced from PubMed, Web of Science, ScienceDirect, and Scopus databases. Following the inclusion and exclusion criteria, a total of 24 studies, comprising 1041 patients, and 100 mice were incorporated. R software was employed for conducting meta-analyses, and calculating effect sizes between experimental and control groups.</p><p><strong>Results: </strong>In human models, significant discrepancies were revealed in waist circumference (Z = -2.16; p = 0.031), hip circumference (Z = 2.11; p = 0.035), insulin levels (Z = 2.11; p = 0.035), and triglycerides (Z = -2.4674, p = 0.0136). In animal models, significant differences were observed in epididymal adipocyte area (Z = -5.6930; p < 0.0001), triglycerides (Z = -2.0254; p = 0.04848), and glucose area under the curve (AUC; Z = -6.4112; p < 0.0001).</p><p><strong>Conclusions: </strong>This study underscores the necessity of considering diverse wavelengths in PBM research, particularly within the realm of obesity, and emphasizes the imperative for further investigations to comprehensively elucidate PBM mechanisms and applications. The exploration of innovative therapeutic approaches unfolds novel avenues in the pursuit of comprehensive strategies to address obesity and its underlying determinants.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13921"},"PeriodicalIF":8.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do glucagon-like Peptide-1 receptor agonists affect measures of muscle mass in individuals with, and without, type 2 diabetes: A systematic review and meta-analysis.","authors":"Oluwaseun Anyiam, Arash Ardavani, Rushdina Sofia Abdul Rashid, Avinash Panesar, Iskandar Idris","doi":"10.1111/obr.13916","DOIUrl":"https://doi.org/10.1111/obr.13916","url":null,"abstract":"<p><p>Glucagon-like peptide-1 receptor agonists (GLP1RAs) are used for the management of type 2 diabetes (T2DM) and obesity. GLP1RAs induce significant weight loss but concerns have been raised regarding the associated effects on muscle mass (MM). We therefore conducted a systematic review and meta-analysis assessing the effects of GLP1RAs on various measures of MM in individuals living with overweight or obesity, with and without T2DM. Comprehensive search of Medline, Pubmed, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar was performed. Studies involving cohorts with a mean age over 40 years and a mean body mass index over 25 kg.m^-2 were included. The primary outcome was any measure used to estimate MM, whilst fat mass (FM) and total body weight were included as secondary outcomes. Thirty-eight publications, involving 1735 participants, were included in the review. Separate meta-analyses were performed for studies involving participants with T2DM and individuals without T2DM (non-DM). In individuals with T2DM, GLP1RAs induced a non-significant mean reduction in MM measures (-0.74 kg, 95% CI: -1.61, 0.14, p = 0.10), despite significantly reducing FM (-3.18 kg, 95% CI: -4.09, -2.28, p < 0.0001). In the non-DM analysis, a significant mean reduction in MM measures was observed (-1.41 kg, 95% CI: -2.12, -0.71, p = 0.0001), however, this was significantly less than the reduction in FM (-6.02 kg, 95% CI: -7.53, -4.50, p < 0.0001). In both populations, the reduction in measures of MM accounted for less than 20% of the total weight reduction. These findings provide some clarity to clinicians that use GLP1RAs to manage individuals with T2DM and/or obesity, however, further more detailed analysis of the impact of these medications on functional skeletal muscle is required.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13916"},"PeriodicalIF":8.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}