Obesity Reviews最新文献

{"title":"Sweet Misery: Association of Sugar Consumption With Anxiety and Depression-A Systematic Review.","authors":"Manali Deb Barma, Bharathi M Purohit, Harsh Priya, Sneha Malhotra, Upendra S Bhadauria, Ritu Duggal","doi":"10.1111/obr.70003","DOIUrl":"https://doi.org/10.1111/obr.70003","url":null,"abstract":"<p><strong>Background: </strong>Food choices we make have profound implications on mental well-being, and this is an area that demands detailed investigation. Hence, this systematic review was conducted to synthesize evidence to elucidate if sugar consumption is associated with anxiety and depression.</p><p><strong>Methodology: </strong>Electronic databases of PubMed, Cochrane, Scopus, Web of Science, Google scholar, and EMBASE were searched for relevant articles. Cross-sectional, cohort, and case-control studies assessing the influence of sugar consumption on anxiety and depression were included. The Newcastle Ottawa Scale was used for assessing the risk of bias. A systematic review was conducted according to PRISMA guidelines.</p><p><strong>Results: </strong>Twenty-six articles were included for systematic review, out of which 14 were cross-sectional, 10 were cohort, and two were case-control studies. Risk of bias was assessed across all included studies. Nineteen studies were rated as high quality, while the remaining seven were of moderate quality. There was a considerable degree of heterogeneity between the studies, with a wide range of age groups and a lack of consistency in tools to measure anxiety and/or depression, and hence a meta-analysis was not conducted. However, an overall positive association was observed between high intake of sugar and increased risk of anxiety and depressive symptoms in different populations across the globe.</p><p><strong>Conclusion: </strong>Reducing sugar intake may serve as a modifiable risk factor for mental disorders, underscoring the need for public health interventions. A further understanding of the causal directions, as well as mediation mechanisms underlying the complex relationship between sugar consumption and mental disorders, is essential.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e70003"},"PeriodicalIF":8.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Are Adolescents Participating in the Transformation of Healthy Food Environments? A Scoping Review of Empirical Research.","authors":"Allyson R Todd, Putu Novi Arfirsta Dharmayani, Sisi Jia, Rebecca Raeside, Seema Mihrshahi, Katrina E Champion, Penny Farrell, Alice A Gibson, Stephanie R Partridge","doi":"10.1111/obr.70002","DOIUrl":"https://doi.org/10.1111/obr.70002","url":null,"abstract":"<p><p>Adolescence (10-19 years) is a pivotal life stage, presenting both risks and opportunities for optimizing nutrition. There are global calls advocating for adolescents to play a central role in transforming food environments. The extent to which adolescents have participated in research to improve food environments is unknown. A scoping review was conducted to investigate the extent, impact, and processes of adolescent participation in food environment research. Included studies were mapped through the Healthy Food Environment Policy Index. Extent, impact (individual/community/national/international-level), and processes (barriers/enablers) were analyzed. Adolescent co-researchers informed each stage. Eighty-nine articles (70 unique studies with 20,697 participants across 31 countries) were identified. Most (81%) were conducted in high-income countries. Food retail (56%) and provision (54%) were most reported, improving the availability of healthy food in their local community and school. Most were adolescent-led (41%); however, only 16% included adolescents throughout each research stage. Impact included improved professional skills and implemented policy. Using engaging participatory methods helped reduce power imbalances. There is substantial evidence of adolescents participating in various modes, methods, and levels of research to transform healthy food environments through policy, demonstrating adolescents can be central actors for change. Ensuring diverse representation from priority population groups and lower-income countries is necessary to reduce the global noncommunicable disease burden.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.","authors":"Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen","doi":"10.1111/obr.13978","DOIUrl":"https://doi.org/10.1111/obr.13978","url":null,"abstract":"<p><p>Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors. These contributors affect regulatory mechanisms in the hypothalamus, hormonal signaling, and the gut-brain axis, all of which control energy intake, expenditure, and energy utilization in body tissues. In this context, particular attention is given to the role of genetic factors, which have a major impact on an individual's susceptibility to disease and support the development of personalized preventive and therapeutic approaches. Modern obesity treatment goes beyond weight reduction and focuses on optimizing body composition by reducing fat mass and increasing lean mass. This review includes a detailed overview of the mechanisms and clinical effects of current pharmacological approaches to obesity treatment, alongside other established strategies such as lifestyle modifications and bariatric surgery. It specifically discusses lipase inhibitors, opioid antagonists, sympathomimetics, and GLP-1 receptor agonists. Looking ahead, emerging therapies-such as microbiota modulation, dual and triple drug combinations, PYY agonists, and monoclonal antibodies-are expected to play a crucial role in the management of obesity. Furthermore, this review explores the potential of CRISPR-based technology for monogenic obesity, opening new avenues for targeted obesity treatments and identifying promising research directions. In the time to come, personalized medicine might have a fundamental place in the management of obesity, providing tailored and more effective therapeutic approaches that prioritize the long-term improvement of body composition and health outcomes in patients.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13978"},"PeriodicalIF":8.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re “Cryolipolysis and Associated Health Outcomes, Adverse Events, and Satisfaction: A Systematic Review and Meta-Analysis” Ravindran et al.","authors":"Nick Finer","doi":"10.1111/obr.70000","DOIUrl":"10.1111/obr.70000","url":null,"abstract":"","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 9","pages":""},"PeriodicalIF":7.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpregnancy Weight Gain and Risks of Perinatal Death: A Systematic Review and Meta-Analysis.","authors":"Yu Tang, Nabil Islam, Rong Luo, Shi Wu Wen, Desheng Zhai, Ying Zhao, Laura M Gaudet, Yanfang Guo, Xiaoping Lei","doi":"10.1111/obr.13981","DOIUrl":"https://doi.org/10.1111/obr.13981","url":null,"abstract":"<p><p>The link between interpregnancy weight gain (IPWG) and perinatal death remains unclear. This meta-analysis examines the impact of interpregnancy body mass index (BMI) increase on perinatal mortality. A comprehensive search was conducted in July 2024 across MEDLINE, Embase, Cochrane Library, and Web of Science. Observational studies quantitatively reporting IPWG and associated perinatal mortality outcomes were included. IPWG was defined as a weight gain of ≥ 2 BMI units or moving to a higher BMI category between consecutive pregnancies. The risk of bias was assessed using the ROBINS-I tool. Random effects meta-analyses were performed to generate pooled adjusted odds ratios (aORs) and 95% confidence intervals (CIs). The analysis included 10 studies (3,072,698 pregnancies). The primary outcome was perinatal death (deaths occurring at ≥ 20 weeks of gestation up to 28 days postpartum). Secondary outcomes were stillbirth (intrauterine fetal death at ≥ 20 weeks) and neonatal death (deaths among live-born infants within 28 days of life). IPWG significantly increases the risk of perinatal death (aOR, 1.49; 95% CI, 1.32-1.69), stillbirth (aOR, 1.46; 95% CI, 1.23-1.72), and neonatal death (aOR, 1.39; 95% CI, 1.19-1.61), compared to stable interpregnancy weight. These findings suggest that IPWG may increase the risk of perinatal death, highlighting the importance of weight management counseling during the interpregnancy period.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13981"},"PeriodicalIF":8.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is My Risk? A Mixed-Methods Systematic Review of Risk Perception for Cardiometabolic Pregnancy Complications and Future Cardiometabolic Disease Development.","authors":"Elaine K Osei-Safo, Jennifer McIntosh, Shakira Onwuka, Sophia Torkel, Margaret McGowan, Kristie Cocotis, Caitlyn Angel, Sanjay Varatharaj, Helena Teede, Angela Melder, Sarah Lang, Lisa J Moran","doi":"10.1111/obr.13967","DOIUrl":"https://doi.org/10.1111/obr.13967","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiometabolic pregnancy complications increase future cardiometabolic disease risk. Accurate risk perception plays a central role in adopting risk-reducing lifestyle and health-related behaviors, such as healthy eating, physical activity, and weight management. This review aimed to explore high-risk pregnant and postpartum women's perception of their risk of developing cardiometabolic pregnancy complications or future cardiometabolic disease.</p><p><strong>Methods: </strong>Systematic search identified quantitative and qualitative data exploring risk perception in women (pregnant/postpartum) at risk of or diagnosed with gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), intrauterine growth restriction (IUGR), and preterm birth (PTB). A convergent integrated mixed-methods synthesis was undertaken, with findings interpreted using the health belief and capability, opportunity, and motivation for behavior change models.</p><p><strong>Results: </strong>Overall, 84 studies were included, with the majority in GDM (77.4%) and HDP (23.8%), with limited research in PTB (8.3%) and IUGR (6.0%). Women had low-moderate knowledge of pregnancy complications as risk factors for future cardiometabolic disease and low-moderate perceived susceptibility to potential pregnancy complications and future cardiometabolic disease. Self-perceived barriers, facilitators, cues to action, self-efficacy, and self-optimism impacted engagement with lifestyle and screening measures. The highest risk perception for future type 2 diabetes or cardiovascular disease was among women who had previously experienced GDM or HDP, respectively.</p><p><strong>Conclusion: </strong>Designing interventions to optimize women's risk perception will support informed decision-making and empower women to make lifestyle changes to reduce future cardiometabolic risk.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13967"},"PeriodicalIF":8.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi Consensus Among French Obesity Experts on Clinical Recommendations for Drug Prescription in Patients With Severe Obesity.","authors":"Sarah Berdot, Germain Perrin, Emmanuel Disse, Armelle Arnoux, Eric Bertin, Anne-Laure Borel, Marie-Claude Brindisi, Arnaud De Luca, Edouard-Jules Laforgue, Jean-Daniel Lalau, Yann Matussiere, Emilie Montastier, Agnès Sallé, Bérénice Segrestin, Valentine Suteau, Sebastien Czernichow, Brigitte Sabatier","doi":"10.1111/obr.13977","DOIUrl":"https://doi.org/10.1111/obr.13977","url":null,"abstract":"<p><strong>Introduction: </strong>Although the physiologic alterations seen in obesity often affect the pharmacokinetics and pharmacodynamics of drugs, most clinical trials do not consider these aspects specifically for this population. To date, there is no list of potentially inappropriate medications for patients living with obesity. The aim of this study was to use the Delphi method to identify useful recommendations for the prescription of some specific drug classes in patients living with severe obesity.</p><p><strong>Methods: </strong>We identified five therapeutic groups of drugs using data from the HEGP Clinical Data Warehouse. We conducted a literature review and sought the opinions of local experts to produce potential recommendations. We selected volunteer medical experts from the French network FORCE and set up a two-round Delphi method, concluded by a synthesis meeting, to establish a list of recommendations. In each round, the experts were asked to rate the potential recommendations.</p><p><strong>Results: </strong>Forty-three proposed recommendations were evaluated in the first round. The experts approved four recommendations with a strong consensus and 16 with a relative consensus. In the second round, they approved six recommendations with a strong consensus and 13 with a relative consensus.</p><p><strong>Conclusion: </strong>This is the first study to use the Delphi method to produce a summary of consensus recommendations for several drug classes in patients living with severe obesity. It provides an expert-based consensus on the use of the five most commonly prescribed therapeutic drug classes and develops a list of recommendations for drug prescription in patients living with severe obesity.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13977"},"PeriodicalIF":8.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Cultural Competence and Cultural Responsiveness of Healthcare Services That Promote Early Prevention of Childhood Obesity: A Scoping Review.","authors":"Zoe Chen, Sarah El Wazni, Erin Kerr, Huilan Xu, Li Ming Wen, Sarah Taki","doi":"10.1111/obr.13979","DOIUrl":"https://doi.org/10.1111/obr.13979","url":null,"abstract":"<p><strong>Background: </strong>Early childhood is a critical period to prevent future poor health outcomes. The modification of health behaviors in the first 2000 days of life is particularly crucial. Yet, obesity is increasingly prevalent in children from culturally and linguistically diverse (CALD) backgrounds, demonstrating a need to provide culturally-tailored care to this population.</p><p><strong>Aims: </strong>To understand the extent of literature that explores cultural competence and responsiveness of preventive healthcare services delivered to culturally and linguistically diverse families (CALD) in the first 2000 days and to identify gaps in the literature and key characteristics and outcomes in these studies that are associated with culturally competent and responsive healthcare.</p><p><strong>Methods: </strong>A search strategy was developed, and five databases were searched. Title and abstract screening, full-text screening, data extraction, and quality appraisal were performed by two or more independent reviewers.</p><p><strong>Results: </strong>A total of 28 included studies identified bilingual facilitators, language-modified materials, and educational resources as key characteristics associated with culturally competent care. Improved breastfeeding practices and increased engagement with healthcare services were identified as key outcomes. Studies involving healthcare cultural competence training were associated with significant changes in outcomes.</p><p><strong>Conclusion: </strong>Many characteristics and health outcomes associated with culturally competent and responsive care were identified in this review. However, preventive health services delivered to CALD families are still an area of research and practice that is lacking cultural competence. A multidisciplinary and community-centered approach is needed to improve health services delivered to CALD families and address persistent barriers to healthcare.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13979"},"PeriodicalIF":8.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Effects of Exercise Timing on Metabolic Health\".","authors":"","doi":"10.1111/obr.13976","DOIUrl":"https://doi.org/10.1111/obr.13976","url":null,"abstract":"","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13976"},"PeriodicalIF":8.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Do Trauma- and Violence-Informed Care Approaches Underpin Bariatric Surgery Interventions for Type 2 Diabetes Mellitus Remission? A Scoping Review.","authors":"Michelle Greenway, Michelle Domjancic, Yixuan Claire Liu, Alegria Benzaquen, Megan Racey, Susan M Jack, Diana Sherifali, Carly Whitmore","doi":"10.1111/obr.13980","DOIUrl":"https://doi.org/10.1111/obr.13980","url":null,"abstract":"<p><p>For individuals living with obesity, bariatric surgery is an effective intervention for type 2 diabetes mellitus (T2DM) remission. Given the established relationships between trauma and obesity, and obesity and T2DM, there is a need to examine bariatric surgical practices from a trauma- and violence-informed care (TVIC) perspective. The purpose of this scoping review was to explore and describe the extent to which the four TVIC principles-(1) understand trauma, violence, and its impact; (2) create emotionally and physically safe environments; (3) foster opportunities for choice, collaboration, and connection; and (4) use a strengths-based and capacity-building approach-have been integrated into bariatric surgery processes for T2DM remission. Following the PRISMA-ScR framework, we searched MEDLINE and EMBASE from inception to January 2024. Eligible studies included adults ≥ 18 years with T2DM undergoing bariatric surgery and reporting remission outcomes. Data were summarized narratively and charted using the TIDieR checklist. Nineteen studies were included, described in 30 publications. Despite established associations between trauma, obesity, and chronic illness, none of the included studies collected demographic data on participants' history of trauma or violence. Among included studies, mental health exclusions were common, potentially limiting access for individuals with trauma-related mental health challenges. Our findings highlight the absence of reporting TVIC principles in bariatric surgery for T2DM remission, raising concerns about emotional safety, risks for retraumatization, and long-term outcomes. Integrating the principles of TVIC throughout bariatric surgical care is essential to promote emotionally safe and inclusive care to enhance postoperative success and sustained health outcomes.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13980"},"PeriodicalIF":8.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}