Kimberley Ann Bennett, Calum Sutherland, Anne Louise Savage
{"title":"A systematic review of evidence that environmental contaminant exposure impedes weight loss and glycemic control during calorie-restricted diets in humans.","authors":"Kimberley Ann Bennett, Calum Sutherland, Anne Louise Savage","doi":"10.1111/obr.13886","DOIUrl":"https://doi.org/10.1111/obr.13886","url":null,"abstract":"<p><p>Calorie-restricted diets cause weight loss and can drive type 2 diabetes remission. However, many patients struggle to achieve clinically relevant weight loss, and the reasons are not well understood. Chemical exposure is associated with obesity and type 2 diabetes development, and some evidence from preclinical experiments suggests it can limit the clinical benefits of calorie restriction. We systematically reviewed the evidence for the effects of environmental chemical exposure on mass loss and glycemic control during diet-induced weight management in humans (PROSPERO: CRD42022339993). Of 222 unique citations, only six papers directly examined this question. Only one targeted people with type 2 diabetes. One linked phthalates and parabens, but not bisphenols, with slower fat loss. Two showed per- and polyfluoroalkyl substances were not associated with mass loss, but with faster subsequent mass regain. One linked impaired adiposity improvements with air pollutants. Two papers reported weight loss-induced elevation in plasma organochlorines associated with altered glycemic control. The risk of bias largely arose from the potential for deviation from the intended diet, and statistics and reporting. The role of chemical exposure in impeding the effectiveness of weight management programs needs to be better understood to provide suitable support to people living with obesity and type 2 diabetes.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13886"},"PeriodicalIF":8.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haitham Jahrami, Waqar Husain, Khaled Trabelsi, Achraf Ammar, Seithikurippu R Pandi-Perumal, Zahra Saif, Marc N Potenza, Chung-Ying Lin, Amir H Pakpour
{"title":"A meta-analysis assessing reliability of the Yale Food Addiction Scale: Implications for compulsive eating and obesity.","authors":"Haitham Jahrami, Waqar Husain, Khaled Trabelsi, Achraf Ammar, Seithikurippu R Pandi-Perumal, Zahra Saif, Marc N Potenza, Chung-Ying Lin, Amir H Pakpour","doi":"10.1111/obr.13881","DOIUrl":"https://doi.org/10.1111/obr.13881","url":null,"abstract":"<p><p>Food addiction (FA) is linked to eating disorders and obesity. The Yale Food Addiction Scale (YFAS), which has various versions in different languages, is widely used to assess FA worldwide. This meta-analysis aimed to assess the YFAS through reliability generalization meta-analysis (REGEMA). From their inception until April 2024, a comprehensive systematic review across more than 30 databases was conducted to identify studies reporting reliability measures (e.g., Cronbach's alpha and McDonald's omega) of the YFAS. Sixty-five studies were included in this meta-analysis, with a median sample size of 451 participants. The results of the random-effects meta-analysis showed a high pooled reliability coefficient (α = 0.85, 95% CI: 0.83 to 0.86 p < 0.001). Test-retest reliability was also estimated using a random-effects meta-analysis of 10 studies, resulting in a pooled test-retest correlation coefficient of intraclass coefficients of (ICC = 0.77, 95% CI: 0.70 to 0.84, p < 0.001). These findings highlight the consistency and robustness of the YFAS in detecting FA across studies, suggesting its reliability for screening for FA-related disordered eating.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13881"},"PeriodicalIF":8.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheida Zeraattalab-Motlagh, Evelyn Syau, Hafza Dadabhoy, Allie L Hardin, Salma M A Musaad, Rebekah Julie Park, Tom Baranowski, Debbe Thompson, Jennette P Moreno
{"title":"Impact of child summertime obesity interventions on body mass index and weight-related behaviors: A systematic review and meta-analysis.","authors":"Sheida Zeraattalab-Motlagh, Evelyn Syau, Hafza Dadabhoy, Allie L Hardin, Salma M A Musaad, Rebekah Julie Park, Tom Baranowski, Debbe Thompson, Jennette P Moreno","doi":"10.1111/obr.13883","DOIUrl":"https://doi.org/10.1111/obr.13883","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity during childhood is a critical public health issue. The summer break from school is a time when children are prone to accelerated weight gain. We aimed to investigate how obesity prevention or treatment programs implemented over the summer affect anthropometric measures or weight-related behaviors.</p><p><strong>Methods: </strong>Published studies examining the impact of obesity prevention/treatment interventions targeting the summer with anthropometric or weight-related behaviors in children (5-18 years old) were identified using systematic searches of Medline, Cochrane, Scopus, CINAHL, PsycINFO, and EMBASE until April 2024. The summarized effect estimate was computed by applying the random-effects approach. The evidence certainty was assessed using GRADE.</p><p><strong>Results: </strong>Forty-seven studies were identified for inclusion. The majority of studies identified focused on physical activity and dietary habits. Only six studies that examined the effects of prevention interventions on weight, body mass index (BMI), and waist circumference (WC) were meta-analyzed. There was no evidence that prevention interventions impacted children's weight, BMI, and WC. However, most of the studies included in the systematic review indicated beneficial effects of interventions for anthropometric measures.</p><p><strong>Conclusion: </strong>There was no evidence that summertime obesity interventions targeting physical activity and dietary intake were effective in the prevention of obesity in children.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13883"},"PeriodicalIF":8.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bernadette Chimera, Rachel Hoobler, Mélanie Deschasaux-Tanguy, Eugenie Van Merris, Ophelia Roels, Mary Playdon, Nathalie Michels, Inge Huybrechts
{"title":"The gut microbiome and eating behavior outcomes: A systematic review.","authors":"Bernadette Chimera, Rachel Hoobler, Mélanie Deschasaux-Tanguy, Eugenie Van Merris, Ophelia Roels, Mary Playdon, Nathalie Michels, Inge Huybrechts","doi":"10.1111/obr.13880","DOIUrl":"10.1111/obr.13880","url":null,"abstract":"<p><strong>Background: </strong>Dysfunctional eating behaviors, and their modulators, are an important component in the prevalence of malnutrition. The gut microbiome, acting through the microbiota-gut-brain axis, is implicated as a modifiable factor in eating behavior. ObjectivesThis systematic review investigated the influence of the gut microbiome on human eating behavior and their modulators (appetite, satiety, energy/food intake, weight loss/gain).</p><p><strong>Methods: </strong>Literature was retrieved from PubMed, Embase, and Web of Science until July 2022. In total, 37 studies were included, with interventions including pre/post/syn-biotics. The primary outcome was eating behaviors, and their modulators.</p><p><strong>Results: </strong>The gut microbiome was associated with eating behaviors, and their modulators, in 28 studies, particularly affecting appetite/appetite hormones, energy/food intake, and weight gain. Intake of probiotics and synbiotics were inconsistently related to appetite and appetite hormone levels, (n = 6 and n = 2 respectively). Prebiotic supplementation showed a consistent trend in the reduction of appetite (n = 4), regulation of appetite hormone levels (n = 10), and increase in self-reported satiety (n = 4). Conversely, energy intake (n = 18) and weight gain/loss (n = 7) were inconsistently associated with probiotic interventions across studies, populations, and interventions. In terms of quality of evidence, most publications had a high risk or some concerns of risk of bias, with fewer than 25% falling into the low-risk category.</p><p><strong>Conclusion: </strong>This review provides an overview of the links between the gut microbiome and human eating behavior across human phenotypes. While explicit associations between specific microbiome taxa and eating behavior are identified, further evidence is needed to substantiate causal relationships. Future research with standardized methods and prospective designs is needed.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13880"},"PeriodicalIF":8.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of obesity or metabolic syndrome with various allergic diseases: An overview of reviews","authors":"Yasutaka Kuniyoshi, Yasushi Tsujimoto, Masahiro Banno, Shunsuke Taito, Takashi Ariie, Takeru Kimoto","doi":"10.1111/obr.13862","DOIUrl":"10.1111/obr.13862","url":null,"abstract":"<div>\u0000 \u0000 <p>The relationship between obesity, metabolic syndrome, related disorders, and various allergic diseases remains unclear. An overview of reviews investigating potential associations between obesity or metabolic syndrome and various allergic diseases was conducted. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched. Systematic reviews and meta-analyses with summary effect size and corresponding 95% confidence intervals for at least one outcome (asthma, atopic dermatitis, and various allergic diseases) were included. This study encompassed 17 systematic review articles and 29 eligible meta-analyses. All included meta-analyses indicated a positive association between obesity/overweight and asthma. Three meta-analyses from one review demonstrated a positive association between obesity/overweight and the risk of atopic dermatitis. However, no meta-analyses focused on the associations between obesity/overweight or metabolic syndrome and allergic rhinitis, allergic conjunctivitis, or other allergic conditions. All included reviews employed poor methodology according to the AMSTAR-2 assessment tools. Our findings suggest that obesity likely increases the risk of asthma. However, evidence for associations with other allergic diseases is limited. Furthermore, no meta-analyses were conducted to assess the relationship between metabolic syndrome and allergic diseases. Further studies are necessary to elucidate the associations between obesity and the full spectrum of allergic diseases.</p>\u0000 </div>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":"26 3","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Delminda Neves, Ana Catarina Neto, Maria Salazar, Ana Sofia Fernandes, Margarida Martinho, Ana Charrua, Adriana Raquel Rodrigues, Alexandra Maria Gouveia, Henrique Almeida
{"title":"A narrative review about the intricate crosstalk among endometrium, adipose tissue, and neurons in endometriosis. The multifaceted role of leptin.","authors":"Delminda Neves, Ana Catarina Neto, Maria Salazar, Ana Sofia Fernandes, Margarida Martinho, Ana Charrua, Adriana Raquel Rodrigues, Alexandra Maria Gouveia, Henrique Almeida","doi":"10.1111/obr.13879","DOIUrl":"https://doi.org/10.1111/obr.13879","url":null,"abstract":"<p><p>Endometriosis is a highly prevalent gynecological disease characterized by the presence of endometrium-like tissue outside the uterus, whose etiopathology is far from being elucidated. The most frequent complains of patients are pelvic pain and infertility. Increasing evidence supports the systemic impact of endometriosis suggesting that an intricate crosstalk among distinct organs underlies the development of the disease. In this setting, endometriosis patients present an increased risk for developing other diseases, such as cancer, cardiovascular pathologies, and autoimmune diseases, and manifest neurologic disturbances, including neuropathic hyperalgesia. Whilst the ovary-secreted estrogen dependency of ectopic endometrium growth is well established, we conjecture that adipose tissue-secreted molecules also intervene in endometriosis development and pain manifestation. In fact, women with endometriosis present a peculiar pattern of adipokine secretion that ensues the disease onset. Unexpectedly, the levels of adipose tissue-secreted molecules in those women present similarities with those found in patients with obesity, despite the recognized association of low body mass index with endometriosis. Taking this evidence into consideration, we hypothesize that endometriosis patients present a dysfunctional adipose tissue, which is associated with enhanced metabolism and unregulated browning that not only intervene in the control of body weight but also in peculiar pain processing pathways.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13879"},"PeriodicalIF":8.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimating global prevalence of mild cognitive impairment and dementia in elderly with overweight, obesity, and central obesity: A systematic review and meta-analysis.","authors":"Junlun Wei, Xinyue Zhu, Jiaye Liu, Yun Gao, Xinjun Liu, Ke Wang, Xiaofeng Zheng","doi":"10.1111/obr.13882","DOIUrl":"https://doi.org/10.1111/obr.13882","url":null,"abstract":"<p><strong>Background and aim: </strong>Previous studies have demonstrated that adiposity, particularly obesity during midlife, may have a detrimental effect on cognitive function. This study aims to estimate the global prevalence of mild cognitive impairment (MCI) and dementia in elderly aged 60 years or above with overweight, obesity, and central obesity.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Web of Science, and Cochrane Library from inception to November 2023. DerSimonian-Laird random-effects model with Logit transformation was used. Sensitivity analysis, meta-regression, and subgroup analysis were employed to investigate determinants of the prevalence of MCI and dementia.</p><p><strong>Results: </strong>A total of 72 studies involving 2,980,947 elderly with distinct adiposity status were included. Pooled prevalence of MCI and dementia in elderly with overweight and obesity was 32.54% and 9.47%, respectively. Univariate meta-regression analysis indicated that the heterogeneity in dementia prevalence was attributable to variations in study size (R<sup>2</sup> = 0.01, p < 0.05), while the multivariable analysis underscored that the income of country or area had the most significant predictive importance (60.3% and 90.3%) for both MCI and dementia prevalence. Subgroup analysis revealed regional disparities and diagnostic technique variations contributing to heterogeneity. Based on currently available but inadequate epidemiological data, the pooled prevalence of MCI and dementia in elderly with central obesity was calculated as 10.18% and 9.75%, respectively.</p><p><strong>Conclusion: </strong>Strategies to address adiposity-associated cognitive impairment should consider multifaceted interventions beyond simple weight reduction. Macro-level initiatives such as improvement of income levels and micro-level interventions including the adoption of accurate diagnostic techniques also represent equally pivotal components.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13882"},"PeriodicalIF":8.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noor Imad, Heidi Turon, Alice Grady, Stephen Keenan, Rebecca Wyse, Luke Wolfenden, Helen Almond, Regina Belski, Alecia Leonard, Anna Peeters, Serene Yoong
{"title":"Identifying effective obesity prevention intervention components: An umbrella review mapping systematic review evidence.","authors":"Noor Imad, Heidi Turon, Alice Grady, Stephen Keenan, Rebecca Wyse, Luke Wolfenden, Helen Almond, Regina Belski, Alecia Leonard, Anna Peeters, Serene Yoong","doi":"10.1111/obr.13878","DOIUrl":"https://doi.org/10.1111/obr.13878","url":null,"abstract":"<p><p>This overview of reviews synthesizes the effectiveness of obesity prevention interventions in children and adults on BMI/zBMI, following JBI and Cochrane Handbook guidelines. The protocol was prospectively registered in OSF in September 2020. Searches for eligible reviews were run in five databases and gray literature in May 2022. Systematic reviews published in 2010 and assessed BMI/zBMI outcomes of obesity prevention interventions were eligible. Screening, data extraction, and quality assessment were performed independently and in duplicate using standardized tools. For similar interventions, the more recent, higher-quality review was included. Thirty reviews reporting on 60 discrete interventions (i.e., a specific intervention component), mapped to 14 of 21 IOM sub-domains, were included. Nine interventions were classified as effective in improving BMI outcomes, including digital health or counseling interventions for adults in 'healthcare environments', behavioral interventions for children (broadly nutrition education), physical education curriculum modifications, and policies targeting food and beverages in 'School environments'. This review extends on previous reviews by consolidating evidence from high-quality, recent reviews to identify effective intervention components. Thus, this review provides direction for implementation efforts and highlights research gaps, where future research is warranted. However, as primary studies were not directly analyzed, gaps may reflect a lack of systematic reviews rather than primary research.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13878"},"PeriodicalIF":8.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Youth involvement in policy processes in public health, education, and social work-A scoping review.","authors":"Gerd Flodgren, Arnfinn Helleve, Annlaug Selstø, Anne-Siri Fismen, Laurence Blanchard, Harry Rutter, Knut-Inge Klepp","doi":"10.1111/obr.13874","DOIUrl":"https://doi.org/10.1111/obr.13874","url":null,"abstract":"<p><strong>Introduction: </strong>Youth involvement in policy formulation may enhance its relevance, strengthen democratic practices, and contribute to youth development. This scoping review explored the nature, extent, and impact of adolescent involvement in policy processes aimed at improving adolescent health and well-being in the public health, education, and social work sectors.</p><p><strong>Methods: </strong>Studies of adolescent involvement in policy processes focusing on health, and well-being, including obesity prevention were eligible. We searched seven databases, reference lists of included studies, and contacted key organizations. Standard scoping review methods were applied. The results were synthesized narratively, using descriptive statistics and visuals.</p><p><strong>Results: </strong>We included 33 mostly qualitative studies, mainly from the public health sector in the USA and Europe, focusing on diet, physical activity, health & well-being, or sexual and reproductive health. Adolescents were consulted or collaborated with, mostly in identifying problems or policy solutions and less often in agenda-setting, decision-making, and evaluation. Various facilitators were used to improve participation (e.g. training, adult facilitators, monetary compensation). Data on adolescents' experiences of involvement and the impact on policies were limited.</p><p><strong>Conclusion: </strong>Due to a paucity of impact studies, we could not determine whether adolescent involvement increased the relevance of policies or improved adolescent development. The extent to which adolescents were meaningfully involved, and had a material effect on decision-making, was largely unclear. Improved documentation, monitoring, and evaluation of youth involvement in policy using quantitative methods and standardized frameworks, can improve the evidence-based, involvement practices, and decrease inequities.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13874"},"PeriodicalIF":8.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin Wood, Kelly Garton, Penelope Milsom, Phillip Baker, Kim Anastasiou, Joshua Clark, Boyd Swinburn, Gary Sacks
{"title":"Using a systems thinking approach to map the global rise of ultra-processed foods in population diets.","authors":"Benjamin Wood, Kelly Garton, Penelope Milsom, Phillip Baker, Kim Anastasiou, Joshua Clark, Boyd Swinburn, Gary Sacks","doi":"10.1111/obr.13877","DOIUrl":"https://doi.org/10.1111/obr.13877","url":null,"abstract":"<p><p>A key driver of obesity and diet-related illness globally has been the increased consumption of ultra-processed foods (UPFs). This paper aimed to identify the key actors, structures, incentives, and dynamics that characterize the global UPF system and have led to the dominance of UPFs in population diets. Based on a narrative review and using a systems thinking approach, we developed a causal loop diagram (CLD) of the global UPF system. The CLD comprises nine reinforcing loops: the commodification of diets; increasing market concentration; increasing UPF levels in food retail environments; the financialization of diets; direct corporate political influence; increasing capture of science, public opinion, and policy narratives; shifts from private to public food governance; state accommodation of corporate power; and an \"agricultural regime\" promoting the production of relatively cheap UPF inputs. The CLD also contains two balancing loops relating to market saturation and public health policies that curb UPF consumption and a countervailing reinforcing loop depicting other forms of food systems in tension with the UPF system. This study suggests the need for innovative and expansive government policies to protect and promote healthy, sustainable diets and coordinated advocacy efforts among those seeking to challenge the exploitative aspects of corporate food systems.</p>","PeriodicalId":216,"journal":{"name":"Obesity Reviews","volume":" ","pages":"e13877"},"PeriodicalIF":8.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}