Journal of Natural Medicines最新文献

Potential α-glucosidase inhibitors from cultures of Biscogniauxia capnodes SWUF15-40 fungus.

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-26 DOI: 10.1007/s11418-025-01876-9

Audomsak Churat, Praewpan Katrun, Chittima Laohpongspaisan, Wiyada Mongkolthanaruk, Chamaiporn Champasri, Pairot Moontragoon, Nuttika Suwannasai, Ek Sangvichien, Pakarapon Poonsukkho, Sirirath McCloskey

{"title":"Potential α-glucosidase inhibitors from cultures of Biscogniauxia capnodes SWUF15-40 fungus.","authors":"Audomsak Churat, Praewpan Katrun, Chittima Laohpongspaisan, Wiyada Mongkolthanaruk, Chamaiporn Champasri, Pairot Moontragoon, Nuttika Suwannasai, Ek Sangvichien, Pakarapon Poonsukkho, Sirirath McCloskey","doi":"10.1007/s11418-025-01876-9","DOIUrl":"https://doi.org/10.1007/s11418-025-01876-9","url":null,"abstract":"The search for a potent α-glucosidase inhibitor from the fungus Biscogniauxia capnodes SWUF15-40 yielded eighteen compounds. A comprehensive analysis from NMR and MS data revealed three new α-pyrones, biscogniapyrones A-C (1-3), two new isocoumarins (5 and 6), and thirteen known compounds. The configurations were assigned from calculated 13C NMR chemical shifts and ECD spectra, together with 1H NMR analysis of Mosher esters. Several compounds exhibited effective inhibitory activity against α-glucosidase with IC50 values in the range of 0.041-0.257 mM, which are lower than the positive control, acarbose (IC50 0.713 mM). The proposed non-competitive mode of inhibition was deduced from Lineweaver-Burk plots together with Km and Vmax values. In silico dockings of the strongest inhibitor, compound 3 were studied. Three out of the five determined allosteric sites of the enzyme model were favorable, with closed free binding energies of roughly - 4.00 kcal/mol. The binding interactions observed between 3 and amino acids in the pocket sites were hydrogen bonding and hydrophobic interactions. These findings, therefore, provide opportunities for drug development processes to be carried out.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SIRT5: a potential target for discovering bioactive natural products.

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-20 DOI: 10.1007/s11418-024-01871-6

Yuwei Xie, Nali Cai, Xiaohua Liu, Liangliang He, Yiming Ma, Changyu Yan, Juan Liang, Shu-Hua Ouyang, Ao Luo, Yingzhi He, Jun Lu, Dang Ao, Jia Liu, Zhonglv Ye, Bin Liu, Rong-Rong He, Wen Li

{"title":"SIRT5: a potential target for discovering bioactive natural products.","authors":"Yuwei Xie, Nali Cai, Xiaohua Liu, Liangliang He, Yiming Ma, Changyu Yan, Juan Liang, Shu-Hua Ouyang, Ao Luo, Yingzhi He, Jun Lu, Dang Ao, Jia Liu, Zhonglv Ye, Bin Liu, Rong-Rong He, Wen Li","doi":"10.1007/s11418-024-01871-6","DOIUrl":"https://doi.org/10.1007/s11418-024-01871-6","url":null,"abstract":"Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mitochondrial matrix. SIRT5 plays a key role in metabolism and antioxidant responses, and is an important regulator for maintaining intracellular homeostasis. Given its involvement in multiple cellular processes, dysregulation of SIRT5 activity is associated with a variety of diseases. This review explores the structural characteristics of SIRT5 that influence its substrate specificity, highlights recent research advances, and summarizes its four key enzymatic activities along with their corresponding substrates in disease contexts. We also discuss the natural products that modulate SIRT5 activity and identify potential targets of SIRT5 through virtual docking, which may provide new therapeutic avenues. Although the mechanism of SIRT5 in diseases needs to be further elucidated and deglutathionylation activities are still at an early stage, targeting SIRT5 and its substrates holds significant promise for the development of novel therapeutics.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway.

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-18 DOI: 10.1007/s11418-024-01869-0

Min-Hui Zhang, Fang Liu, Wen-Hui Gao, Zhao-Kun Liu

引用次数: 0

Meroterpenes and prenylated acylphloroglucinol from the aerial parts of Hypericum erectum.

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-18 DOI: 10.1007/s11418-025-01883-w

Rena Takizawa, Chiaki Nagata, Sang-Yong Kim, Daisuke Tsuji, Mareshige Kojoma, Reiko Akagi, Yoshiki Kashiwada, Naonobu Tanaka

引用次数: 0

Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds.

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-13 DOI: 10.1007/s11418-025-01877-8

Masateru Ono, Renjyu Murakami, Shin Yasuda, Hiroyuki Miyashita, Hitoshi Yoshimitsu, Ryota Tsuchihashi, Masafumi Okawa, Junei Kinjo

{"title":"Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds.","authors":"Masateru Ono, Renjyu Murakami, Shin Yasuda, Hiroyuki Miyashita, Hitoshi Yoshimitsu, Ryota Tsuchihashi, Masafumi Okawa, Junei Kinjo","doi":"10.1007/s11418-025-01877-8","DOIUrl":"https://doi.org/10.1007/s11418-025-01877-8","url":null,"abstract":"Resin glycosides, characteristic of plants of the Convolvulaceae family, are well-known purgative constituents found in traditional medicinal crude drugs, such as Rhizoma Jalapae, Rhizoma Jalapae Braziliensis, Orizaba Jalapa Tuber, and Pharbitidis Semen. The isolated compounds exhibited a wide range of biological activities, including antibacterial, ionophoric, anti-inflammatory, antiviral, and multidrug-resistance-modulating properties, as well as cytotoxicity against cancer cells. Ipomoea lacunosa L. (Convolvulaceae) is an herbaceous vine native to the United States. Four new acylated glycosidic acid methyl esters (1-4) and one new glycosidic acid (5) were isolated from the methanol extract of the plant seed. The structures of 1-5 were elucidated using spectroscopic data in conjunction with our previous studies on the components of the crude resin glycoside fraction from I. lacunosa seeds. Compounds 1 and 2 were identified as heptaglycosides, 3 as an octaglycoside, and 4 as a nonaglycoside, all sharing methyl 3S,11S-dihydroxytetradecanoate as a common aglycone. The saccharide moieties were partially acylated by glycosidic acid, 7S-hydroxydecanoic acid 7-O-β-D-quinovopyranoside, and organic acids, including (E)-2-methylbut-2-enoic, 2S-methylbutyric, and 2R-methyl-3R-hydroxybutyric acids. Compound 5 was identified as a triglycoside with a new aglycone, 4,11-dihydroxyhexadecanoic acid, which is the first glycosidic acid with a hydroxyl group at C-4 of the aglycone moiety.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases.

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-06 DOI: 10.1007/s11418-025-01880-z

Takayoshi Awakawa

引用次数: 0

Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC₅₀: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation.

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-03 DOI: 10.1007/s11418-024-01874-3

Shoji Maehara, Moeka Kumamoto, Shogo Nakajima, Yuhzo Hieda, Koichi Watashi, Toshiyuki Hata

{"title":"Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC50: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation.","authors":"Shoji Maehara, Moeka Kumamoto, Shogo Nakajima, Yuhzo Hieda, Koichi Watashi, Toshiyuki Hata","doi":"10.1007/s11418-024-01874-3","DOIUrl":"https://doi.org/10.1007/s11418-024-01874-3","url":null,"abstract":"Since the coronavirus disease 2019 (COVID-19) outbreak, research has been conducted on treatment and countermeasures against the causative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the development of new seeds is urgently needed because viruses have the characteristic of becoming resistant through mutation. We hypothesize that endophytes produce antiviral substances to combat foreign viruses in host plants. According to this hypothesis, the seeds of therapeutic agents for infectious diseases could be obtained from endophytes by culture experiments. This report found that Aspergillus sp. endophyte isolated from Catharanthus roseus produced ( +)-eupenoxide and its 3-ketone form with anti-SARS-CoV-2 activity. In addition, ( +)-eupenoxide-3,6-diketon was discovered as a new compound with potent 3C-like protease inhibitory activity (IC50: 0.048 μM) by synthesis based on ( +)-eupenoxide. This finding could be an important evidence that endophytic fungi symbiosis with medicinal plants is useful as antiviral producers.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new diterpenoid, carneadiol, isolated from Nocardia carnea IFM 12324.

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-01-28 DOI: 10.1007/s11418-025-01878-7

Yasumasa Hara, Ayaka Nakamura, Teruhisa Manome, Akiko Takaya, Hiroki Takahashi, Sayaka Ban, Takashi Yaguchi, Masami Ishibashi

引用次数: 0

New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities. 曼氏蛇蛾气部新脑苷类及神经酰胺类成分的研究。F.及其细胞毒活性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-01-19 DOI: 10.1007/s11418-024-01875-2

Yves M Mba Nguekeu, Herman D Sonfack Fozeng, Chika Ifeanyi Chukwuma, Saw Y Yu Hnin, Nhat Nam Hoang, Emmanuel Mfotie Njoya, Silvère Augustin Ngouela, Mathieu Tene, Tshepiso Jan Makhafola, Hiroyuki Morita, Maurice Ducret Awouafack

{"title":"New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities.","authors":"Yves M Mba Nguekeu, Herman D Sonfack Fozeng, Chika Ifeanyi Chukwuma, Saw Y Yu Hnin, Nhat Nam Hoang, Emmanuel Mfotie Njoya, Silvère Augustin Ngouela, Mathieu Tene, Tshepiso Jan Makhafola, Hiroyuki Morita, Maurice Ducret Awouafack","doi":"10.1007/s11418-024-01875-2","DOIUrl":"https://doi.org/10.1007/s11418-024-01875-2","url":null,"abstract":"Two new cerebrosides, raphimanosides A (1) and B (2), and a new ceramide, raphimanide (3), were isolated from the aerial parts of Raphidiocystis mannii Hook. f., along with ten known compounds (4-13). Their structures were fully established, based on extensive analyses of 1H, 13C, DEPT, 2D NMR, ESIMS, and HRESIMS data and chemical conversion. Subsequently, methanol extract, ethyl acetate, and n-butanol soluble portions and the isolated compounds 1-9, 12, and 13 were assayed for their cytotoxic effects against three human cancer cell lines (MCF-7, HeLa and A549). None of the new compounds demonstrated efficacy against the tested cell lines. In contrast, the methanol extract, ethyl acetate soluble portion, and compounds 6, 7, 9, 12, and 13 showed moderate to low activities against different tested cell lines. Ethyl acetate soluble portion and compounds 13 and 7 were the most potent samples with the IC50 value of 41.25 μg/mL, 36.76 μM, and 13.16 μM against MCF-7, HeLa, and A549 cell lines, respectively. To the best of our knowledge, this is the inaugural investigation into the chemical constituents of the genus Raphidiocystis, offering novel insights into the chemotaxonomy of this hitherto poorly understood genus.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ergostane-type steroids from mushrooms of Pleurotus genus. 从侧耳菇属蘑菇中提取麦角甾类类固醇。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-01-17 DOI: 10.1007/s11418-024-01872-5

Takashi Kikuchi

引用次数: 0