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Journal of Natural Medicines最新文献

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Pharmacological regulation of airway ciliary motility: endogenous mediators, pharmaceutical agents, and natural compounds with a focus on ginsenoside Rd. 气道纤毛运动的药理调节：内源性介质，药物制剂和天然化合物，重点是人参皂苷Rd。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-30 DOI: 10.1007/s11418-026-02039-0
Kouta Noriyama, Eishi Ashihara
{"title":"Pharmacological regulation of airway ciliary motility: endogenous mediators, pharmaceutical agents, and natural compounds with a focus on ginsenoside Rd.","authors":"Kouta Noriyama, Eishi Ashihara","doi":"10.1007/s11418-026-02039-0","DOIUrl":"https://doi.org/10.1007/s11418-026-02039-0","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Auricularia auricula polysaccharides alleviate Propionibacterium acnes-induced lung sarcoidosis-like granulomatosis in mice via the gut-lung axis. 黑木耳多糖通过肠-肺轴减轻痤疮丙酸杆菌诱导的小鼠肺结节病样肉芽肿病。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-30 DOI: 10.1007/s11418-025-01987-3
Meng-Qi Zhao, Ju-Fang Jia, Tian-Bo Liu, Wen-Jie Wang, Xue-Qing Liu, Wen-Fei Wang, Hai-Xue Kuang, Jun Liang, Yong-Gang Xia
{"title":"Auricularia auricula polysaccharides alleviate Propionibacterium acnes-induced lung sarcoidosis-like granulomatosis in mice via the gut-lung axis.","authors":"Meng-Qi Zhao, Ju-Fang Jia, Tian-Bo Liu, Wen-Jie Wang, Xue-Qing Liu, Wen-Fei Wang, Hai-Xue Kuang, Jun Liang, Yong-Gang Xia","doi":"10.1007/s11418-025-01987-3","DOIUrl":"https://doi.org/10.1007/s11418-025-01987-3","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of human and mouse transient receptor potential vanilloid 1 by enantiomeric evodiamine and rutaecarpine. 对映体evodiamine和rutaecarpine对人和小鼠瞬时受体电位香草素1的激活作用。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-30 DOI: 10.1007/s11418-026-02028-3
Shunsuke Nakamori, Tatsuya Shirahata, Anju Soda, Marie Kashiwazaki, Takahiro Hirota, Yusuke Kawabata, Atsuko Okamura, Yoshihisa Asada, Susumu Ohkawara, Toshiko Tanaka-Kagawa, Hideto Jinno, Yoshinori Kobayashi
{"title":"Activation of human and mouse transient receptor potential vanilloid 1 by enantiomeric evodiamine and rutaecarpine.","authors":"Shunsuke Nakamori, Tatsuya Shirahata, Anju Soda, Marie Kashiwazaki, Takahiro Hirota, Yusuke Kawabata, Atsuko Okamura, Yoshihisa Asada, Susumu Ohkawara, Toshiko Tanaka-Kagawa, Hideto Jinno, Yoshinori Kobayashi","doi":"10.1007/s11418-026-02028-3","DOIUrl":"https://doi.org/10.1007/s11418-026-02028-3","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of chemical compositional profiles and immunomodulatory activity of ginseng in different habitats. 不同产地人参化学成分及免疫调节活性的比较分析。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-30 DOI: 10.1007/s11418-026-02034-5
Chen-Yue Zeng, Quan-Kuan Dai, Hua-Ze Wu, Ao Li, Yong-Lin Chen, Qing-Hui He, Dan Tang, Hong-Yan Ma
{"title":"Comparative analysis of chemical compositional profiles and immunomodulatory activity of ginseng in different habitats.","authors":"Chen-Yue Zeng, Quan-Kuan Dai, Hua-Ze Wu, Ao Li, Yong-Lin Chen, Qing-Hui He, Dan Tang, Hong-Yan Ma","doi":"10.1007/s11418-026-02034-5","DOIUrl":"https://doi.org/10.1007/s11418-026-02034-5","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piperlongumine A attenuates RANKL-induced osteoclastogenesis by targeting MAPK signaling and downregulating c-Fos and NFATc1. 胡椒明A通过靶向MAPK信号和下调c-Fos和NFATc1来减弱rankl诱导的破骨细胞发生。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-30 DOI: 10.1007/s11418-026-02010-z
Tran Thi Thu Phuong, Le Hoang Long, Phan Thi Tu Uyen, Nguyen Xuan Nhiem, Jeong-Hyung Lee, Nguyen Hai Dang
{"title":"Piperlongumine A attenuates RANKL-induced osteoclastogenesis by targeting MAPK signaling and downregulating c-Fos and NFATc1.","authors":"Tran Thi Thu Phuong, Le Hoang Long, Phan Thi Tu Uyen, Nguyen Xuan Nhiem, Jeong-Hyung Lee, Nguyen Hai Dang","doi":"10.1007/s11418-026-02010-z","DOIUrl":"https://doi.org/10.1007/s11418-026-02010-z","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Components with potential anti-inflammatory effect from the seeds of Dolichos lablab. 石菖蒲种子中具有潜在抗炎作用的成分。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-30 DOI: 10.1007/s11418-026-02038-1
Wei Zhang, Yijin Wu, Jiaming Cheng, Jingya Ruan, Yingying Wang, Lequan Yu, Dan Wang, Yi Zhang, Tao Wang
{"title":"Components with potential anti-inflammatory effect from the seeds of Dolichos lablab.","authors":"Wei Zhang, Yijin Wu, Jiaming Cheng, Jingya Ruan, Yingying Wang, Lequan Yu, Dan Wang, Yi Zhang, Tao Wang","doi":"10.1007/s11418-026-02038-1","DOIUrl":"https://doi.org/10.1007/s11418-026-02038-1","url":null,"abstract":"<p><p>Four new nitrogenous compounds, designated as dolilabnitrogenousols A<sub>1</sub>-A<sub>3</sub>, B (1-4), and six new others, namely dolilabnosides A-C, D<sub>1</sub>, D<sub>2</sub> (5-9), and (2S)-[[(3-furanyl)carbonyl]oxy]butanedioic acid (10), along with ten known compounds (11-20), which were initially isolated from Lablab genus, were obtained from the seeds Dolichos lablab L., a plant with medicine food homology. Their structures were determined based on high resolution electrospray ionization MS (HR-ESI-MS) data, various NMR spectroscopic analyses, electronic circular dichroism (ECD) calculations, as well as chemical reactions. Moreover, the expression level of nitric oxide (NO) was measured using a lipopolysaccharide (LPS)-induced RAW264.7 cell model to evaluate the anti-inflammatory activity of the obtained compounds. The results of bioactive assay indicated that compounds 1-4, 6, 7, 10-13, 16, 17, and 20 displayed significant inhibitory activity on NO release in RAW264.7 cells in a dose-dependent manner. Additionally, the structure-activity relationships were summarized. These findings highlight the potential of the ingredients from D. lablab seeds in the treatment of inflammation-related disorders.</p>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ninjin'yoeito Kampo medicine enhances zebrafish endurance under forced-swimming conditions via muscle hypertrophy. 汉布药通过肌肉肥大增强斑马鱼在强迫游泳条件下的耐力。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-21 DOI: 10.1007/s11418-026-02020-x
Kaita Hirano, Jihwan Eum, Haruri Nagata, Yuko Kamada-Futagami, Toshiki Hyodo, Momoko Kawabe, Seiwa Michihara, Shigeki Chiba, Akio Inui, Kazuhiro Shiozaki
{"title":"Ninjin'yoeito Kampo medicine enhances zebrafish endurance under forced-swimming conditions via muscle hypertrophy.","authors":"Kaita Hirano, Jihwan Eum, Haruri Nagata, Yuko Kamada-Futagami, Toshiki Hyodo, Momoko Kawabe, Seiwa Michihara, Shigeki Chiba, Akio Inui, Kazuhiro Shiozaki","doi":"10.1007/s11418-026-02020-x","DOIUrl":"https://doi.org/10.1007/s11418-026-02020-x","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidative effects of diarylheptanoids. 二芳基庚类化合物的抗氧化作用。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-21 DOI: 10.1007/s11418-026-02040-7
Sae Miyagishi, Yohei Saito, Masuo Goto, Kyoko Nakagawa-Goto
{"title":"Antioxidative effects of diarylheptanoids.","authors":"Sae Miyagishi, Yohei Saito, Masuo Goto, Kyoko Nakagawa-Goto","doi":"10.1007/s11418-026-02040-7","DOIUrl":"https://doi.org/10.1007/s11418-026-02040-7","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pistaciaphenols A-E: novel chalcone-based biflavonoids from the branches of Pistacia chinensis. 黄连木酚A-E：从黄连木枝中提取的新型查尔酮类生物黄酮。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-21 DOI: 10.1007/s11418-026-02023-8
Tomoki Mizoguchi, Naohito Abe, Satoshi Endo, Satoshi Okubo, Takao Yamaura, Masayoshi Oyama, Ken-Ichi Nakashima
{"title":"Pistaciaphenols A-E: novel chalcone-based biflavonoids from the branches of Pistacia chinensis.","authors":"Tomoki Mizoguchi, Naohito Abe, Satoshi Endo, Satoshi Okubo, Takao Yamaura, Masayoshi Oyama, Ken-Ichi Nakashima","doi":"10.1007/s11418-026-02023-8","DOIUrl":"https://doi.org/10.1007/s11418-026-02023-8","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The root bark of Paeonia suffruticosa alleviates Staphylococcus aureus-induced pneumonia in mice by modulating toxin secretion and function. 白芍根皮通过调节毒素分泌和功能减轻金黄色葡萄球菌所致小鼠肺炎。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-21 DOI: 10.1007/s11418-026-02012-x
Xibo Xue, Yijiu Gao, Ying-Jian Sun
{"title":"The root bark of Paeonia suffruticosa alleviates Staphylococcus aureus-induced pneumonia in mice by modulating toxin secretion and function.","authors":"Xibo Xue, Yijiu Gao, Ying-Jian Sun","doi":"10.1007/s11418-026-02012-x","DOIUrl":"https://doi.org/10.1007/s11418-026-02012-x","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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