Journal of Natural Medicines最新文献

Poricoic acid A administered during DSS exposure attenuates acute colitis in mice and is accompanied by barrier-associated changes and endpoint fecal microbiota shifts. 在DSS暴露期间给药的茯苓酸A可减轻小鼠急性结肠炎，并伴有屏障相关的变化和终点粪便微生物群的变化。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-09-01 DOI: 10.1007/s11418-026-02076-9

Mei Wang, Kunkun Zhang, Danli Wang, Mingtao Cao, Rong Yong, Xiangqian Li, Wenyi Chen, Chengcheng Peng, Jiale Chang, Lu Fang, Feiyang Zhou, Yuyue Wan, Jingran Wang, Zhi Zhou, Lin Chen

{"title":"Poricoic acid A administered during DSS exposure attenuates acute colitis in mice and is accompanied by barrier-associated changes and endpoint fecal microbiota shifts.","authors":"Mei Wang, Kunkun Zhang, Danli Wang, Mingtao Cao, Rong Yong, Xiangqian Li, Wenyi Chen, Chengcheng Peng, Jiale Chang, Lu Fang, Feiyang Zhou, Yuyue Wan, Jingran Wang, Zhi Zhou, Lin Chen","doi":"10.1007/s11418-026-02076-9","DOIUrl":"https://doi.org/10.1007/s11418-026-02076-9","url":null,"abstract":"Poricoic acid A (PAA), a lanostane-type triterpenoid associated with Poria-derived medicines, has shown tissue-protective activity, but its effects on epithelial-barrier phenotypes and endpoint fecal microbiota in experimental colitis remain incompletely characterized. Male C57BL/6 mice were exposed to 3% dextran sulfate sodium (DSS) for 7 days and received oral PAA (2.5, 5, or 10 mg/kg/day), sulfasalazine (200 mg/kg/day), or vehicle concomitantly with DSS. Clinical disease indices and colon length were assessed; colonic histology, mucus-positive staining, epithelial ultrastructure, serum lipopolysaccharide (LPS), E-cadherin, and claudin-3 were evaluated; and endpoint fecal microbial communities were profiled by 16S rRNA gene sequencing. DSS caused body-weight loss, increased disease activity, colon shortening, histological injury, mucus depletion, epithelial ultrastructural disruption, increased serum LPS, and reduced colonic E-cadherin and claudin-3. PAA attenuated the clinical and histological changes, with the most consistent effects at 10 mg/kg/day, the highest dose tested. This group also showed better-preserved epithelial ultrastructure, lower serum LPS, and higher E-cadherin and claudin-3 signals than the DSS group. Endpoint sequencing showed higher richness-related indices in the PAA-H group than in the DSS group, including Chao1, ACE, observed species, and Faith's phylogenetic diversity, whereas Shannon and Simpson indices were not different. Exploratory taxonomic analyses identified treatment-associated differences in selected DSS-altered fecal taxa, including attenuation of Proteobacteria-related expansion. Thus, PAA administered during DSS exposure attenuated acute colitis and was accompanied by barrier-associated changes and endpoint fecal microbiota alterations.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dracafoliasides A-D, four undescribed spirostanol glycosides from Dracaena angustifolia with nitric oxide production inhibitory activity. 龙血树甙A-D，四种未描述的龙血树螺醇苷类化合物，具有抑制一氧化氮生成的活性。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-08-31 DOI: 10.1007/s11418-026-02078-7

Bui Huu Tai, Pham Hai Yen, Duong Thi Dung, Nguyen Huy Hoang, Phan Thi Thanh Huong, Duong Thi Hai Yen, Nguyen The Cuong, Phan Van Kiem

{"title":"Dracafoliasides A-D, four undescribed spirostanol glycosides from Dracaena angustifolia with nitric oxide production inhibitory activity.","authors":"Bui Huu Tai, Pham Hai Yen, Duong Thi Dung, Nguyen Huy Hoang, Phan Thi Thanh Huong, Duong Thi Hai Yen, Nguyen The Cuong, Phan Van Kiem","doi":"10.1007/s11418-026-02078-7","DOIUrl":"https://doi.org/10.1007/s11418-026-02078-7","url":null,"abstract":"Four undescribed spirostanol glycosides (23S,24S)-spirosta-5,25(27)-dien-1β,3β,23,24-tetrol 1-O-{2,3,4-tri-O-acetyl-α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranoside} 24-O-β-D-quinovopyranoside (1), spirosta-5,25(27)-dien-1β,3β,17α-triol 1-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-xylopyranoside (2), spirosta-5,25(27)-diene-1β,3β,17α-triol 1-O-β-D-glucopyranosyl-(1→3)-O-β-D-xylopyranoside (3), (25R)-spirosta-5-ene-1β,3β,17α-triol 1-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-xylopyranoside (4), together with six known compounds (5-10) were isolated from Dracaena angustifolia roots. Their chemical structures were determined based on extensive spectroscopic analysis, including IR, HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1-3, 5, 7 and 10 significantly inhibited nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with IC50 values ranging from 22.5 to 36.2 µM, while compounds 4 and 9 showed moderate effects with IC50 values of 67.2 and 60.5 µM, respectively.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpikwangsides A-C, three previously undescribed compounds isolated from the rhizomes of Alpinia kwangsiensis and their NO inhibitory activity. Alpikwangsides A-C，三种从Alpinia kwangsiensis根状茎中分离的化合物及其NO抑制活性。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-08-31 DOI: 10.1007/s11418-026-02079-6

Nguyen Thi Mai, Bui Thi Mai Anh, Tran Thuy Nga, Le Thi Huyen, Nguyen Vu Minh Tam, Nguyen Huy Hoang, Nguyen Viet Dung, Nguyen Phuong Thao

引用次数: 0

Discovery of four new malabaricane saponins, malabarosides A-D, from the aerial parts of Dysphania ambrosioides with nitric oxide production inhibitory activity. 从苦参地上部中发现4个具有抑制一氧化氮生成活性的马拉巴皂苷A-D。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-08-28 DOI: 10.1007/s11418-026-02074-x

Phan Van Kiem, Nguyen Thi Viet Ai, Bui Huu Tai, Nguyen Huy Hoang, Phan Thi Thanh Huong, Duong Thi Hai Yen, Do Thi Thao, Nguyen Phuong Thao, Nguyen The Cuong, Bui Van Thanh, Duong Thi Dung, Pham Hai Yen

引用次数: 0

Correction: Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports. 更正：从含有红曲（红曲米）的保健食品中分离出的新化合物有不良事件报告。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-08-28 DOI: 10.1007/s11418-026-02063-0

Seiji Tanaka, Naoko Masumoto, Takuya Makino, Yuji Matsushima, Toshio Morikawa, Michiho Ito

引用次数: 0

Isomucronulatol attenuates liver aging by inhibiting GSK-3β acetylation and promoting β-catenin accumulation. 异多环糖醇通过抑制GSK-3β乙酰化和促进β-连环蛋白积累来减缓肝脏衰老。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-08-18 DOI: 10.1007/s11418-026-02071-0

Peiyao Chen, Baolian Wan, Fei Yu, Yanqiu Zhang, Mengmeng He, Enyi Wu, Yanjun He, Hui Zhong, Hao Zhang

{"title":"Isomucronulatol attenuates liver aging by inhibiting GSK-3β acetylation and promoting β-catenin accumulation.","authors":"Peiyao Chen, Baolian Wan, Fei Yu, Yanqiu Zhang, Mengmeng He, Enyi Wu, Yanjun He, Hui Zhong, Hao Zhang","doi":"10.1007/s11418-026-02071-0","DOIUrl":"https://doi.org/10.1007/s11418-026-02071-0","url":null,"abstract":"Liver aging is a critical contributor to metabolic dysregulation and the development of various liver diseases. Currently, there is no approved therapy specifically targeting liver aging. The potential of medicinal and edible herbs in preventing and treating liver aging has attracted increasing attention. Accordingly, we constructed a self-built compound library containing 87 bioactive constituents isolated from these herbs. This study aimed to identify the potential compound capable of alleviating hepatic senescence from the constructed library and to elucidate the underlying mechanism. Isomucronulatol (Iso), a bioactive isoflavone isolated from Astragalus membranaceus, exhibited potential anti-hepatic senescence activity in a p21 promoter-driven luciferase reporter assay. Iso exhibited significant anti-hepatic senescence activity in H₂O₂-stimulated and doxorubicin (DOX)-stimulated HepG2 cells, as well as in mitomycin C (MC)-exposed AML12 cells, as evidenced by reduced SA-β-Gal positivity, downregulated p21 and p16 expression, and decreased secretion of SASP factors (IL-6, IL-1β, CCL2). In a D-galactose (D-gal)-induced mouse aging model, Iso treatment attenuated liver histological damage, lowered serum ALT and AST levels, and suppressed senescence markers in liver tissues. Transcriptomic and network pharmacology analyses revealed that Iso could activate Wnt/β-catenin signaling pathway to delay hepatic senescence. Mechanistically, Iso could facilitate nuclear accumulation of β-catenin by inhibiting GSK-3β acetylation, thereby restoring Wnt signaling. Collectively, these findings highlight Iso as a potential therapeutic agent against hepatic senescence.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant effects of Gardeniae Fructus on chronic unpredictable mild stress model mice: involvement of DNMT3B-mediated epigenetic regulation of GR in the prefrontal cortex. 栀子子对慢性不可预测轻度应激模型小鼠的抗抑郁作用：参与dnmt3b介导的前额皮质GR表观遗传调控。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-08-18 DOI: 10.1007/s11418-026-02067-w

Lu-Lu Zhang, Xiao-Wei Wang, Yi-Dan Cheng, Ya Liu, Hesham R El-Seedi, Peng-Cheng Sun, Wen-Bin He, Jian-Jun Zhang, Zhi-Guang Zhai

{"title":"Antidepressant effects of Gardeniae Fructus on chronic unpredictable mild stress model mice: involvement of DNMT3B-mediated epigenetic regulation of GR in the prefrontal cortex.","authors":"Lu-Lu Zhang, Xiao-Wei Wang, Yi-Dan Cheng, Ya Liu, Hesham R El-Seedi, Peng-Cheng Sun, Wen-Bin He, Jian-Jun Zhang, Zhi-Guang Zhai","doi":"10.1007/s11418-026-02067-w","DOIUrl":"https://doi.org/10.1007/s11418-026-02067-w","url":null,"abstract":"This study aimed to investigate the antidepressant effects of Gardeniae Fructus (ZZ) and its potential mechanisms related to DNA methylation regulation via network pharmacology, in vivo experiments, and targeted molecular assessments; a depressive mouse model was established with chronic unpredictable mild stress (CUMS), ZZ at low/medium/high doses and fluoxetine as positive control were administered for 4 weeks, depressive-like phenotypes were assessed via behavioral tests, and Western blot, qPCR, immunofluorescence and targeted bisulfite sequencing (TBS) were used to detect key molecules, mRNA expression and gene methylation in the prefrontal cortex (PFC) and hippocampus. The results showed that ZZ significantly ameliorated CUMS-induced depressive-like behaviors with 2 g/kg (equivalent to 10 g in adult humans) as the optimal dose, downregulated DNMT3B and 5-mC levels, upregulated GR and reduced FKBP5 expression in the PFC with no hippocampal alterations, and TBS confirmed GR as a hypermethylated PFC target in CUMS mice while low-dose ZZ reversed hypermethylation at four key GR CpG loci. In conclusion, ZZ exerts antidepressant effects by downregulating PFC DNMT3B, reversing GR hypermethylation and restoring GR/FKBP5 balance to regulate the HPA axis, thus providing a novel epigenetic target for depression therapy.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Salvia miltiorrhiza (Danshen) and its extracts in the alternative treatment of diabetic nephropathy: mechanisms and clinical perspectives. 纠正：丹参及其提取物替代治疗糖尿病肾病：机制与临床观点。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-08-10 DOI: 10.1007/s11418-026-02064-z

Lu Song, Yan Li, Huakui Zhan, Ling Wu, Li Tang, Xinyu Wang, Qinyuan Deng

引用次数: 0

Panax quinquefolius ginsenosides for neuroprotection in Parkinson's disease via TNF-α inhibition. 西洋参皂苷通过抑制TNF-α对帕金森病的神经保护作用。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-08-10 DOI: 10.1007/s11418-026-02066-x

Mengshuang Zhu, Jiyang Tang, Wen Zhan, Peihai Li, Shanshan Zhang, Hairong Hou, Xiaobin Li, Meng Jin, Xuanming Zhang

{"title":"Panax quinquefolius ginsenosides for neuroprotection in Parkinson's disease via TNF-α inhibition.","authors":"Mengshuang Zhu, Jiyang Tang, Wen Zhan, Peihai Li, Shanshan Zhang, Hairong Hou, Xiaobin Li, Meng Jin, Xuanming Zhang","doi":"10.1007/s11418-026-02066-x","DOIUrl":"https://doi.org/10.1007/s11418-026-02066-x","url":null,"abstract":"Parkinson's disease (PD) is characterized by resting tremors and gradual loss of dopaminergic (DA) neurons, increasing the socio-economic burden worldwide. This study aimed to investigate the neuroprotective effects of Panax quinquefolius using the MPTP-induced zebrafish PD model. The length and fluorescence intensity of DA neurons were restored to 96.55% and 73.47% of the control values, respectively, under 25 μg/mL total ginsenoside (TG) treatment. The number of blood vessels in the brain was restored to 91.48% of the control values. The swimming distance and speed of zebrafish were restored to 88.21% and 88.19% of the control values, respectively. A total of 15 ginsenosides were identified from TG using liquid chromatography quadrupole time-of-flight mass spectrometry for exploring their actions on PD. The in silico analyses revealed ginsenoside Rg5, pseudoginsenoside F11, and ginsenoside F4 as the key active components, and tumor necrosis factor (TNF), albumin (ALB), TP53, and interleukin (IL)-6 as the important targets with higher correlation degrees. Molecular docking toward TNF-α demonstrated excellent binding affinities with energy values of -7.18 kcal/mol (ginsenoside Rg5), -6.85 kcal/mol (pseudoginsenoside F11), and -7.34 kcal/mol (ginsenoside F4). Quantitative polymerase chain reaction and enzyme-linked immunosorbent assay showed that ginsenosides inhibited MPTP-induced upregulation of TP53 and IL-6 and reversed the downregulation of VDBP, a homologous transport protein of ALB in the zebrafish model. It was speculated that ginsenosides might influence TNF-α protein, which in turn could modulate the downstream TP53, IL-6, and VDBP (ALB) expression, representing an effective mechanism for alleviating PD symptoms.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-glucuronidase inhibitors isolated from the fruit of Forsythia suspensa (Thunb.) Vahl. 连翘（Forsythia suspensa, Thunb.）果实中β-葡萄糖醛酸酶抑制剂的分离纯化Vahl。

IF 2.6 4区医学

Journal of Natural Medicines Pub Date : 2026-07-28 DOI: 10.1007/s11418-026-02070-1

Shogo Nishikawa, Ryuya Takada, Yusuke Shimomoto, Sara Morishita, Yoshiaki Manse, Tomoe Ohta, Tatsusada Yoshida, Takahiro Matsumoto, Toshio Morikawa

{"title":"β-glucuronidase inhibitors isolated from the fruit of Forsythia suspensa (Thunb.) Vahl.","authors":"Shogo Nishikawa, Ryuya Takada, Yusuke Shimomoto, Sara Morishita, Yoshiaki Manse, Tomoe Ohta, Tatsusada Yoshida, Takahiro Matsumoto, Toshio Morikawa","doi":"10.1007/s11418-026-02070-1","DOIUrl":"https://doi.org/10.1007/s11418-026-02070-1","url":null,"abstract":"A methanol extract from the fruit of Forsythia suspensa (Thunb.) Vahl (Oleaceae), which is used as the crude drug Forsythiae Fructus (Forsythia Fruit; \"Rengyo\" in Japanese) and is listed in the Japanese Pharmacopoeia XIX, exerted enzymatic β-glucuronidase inhibitory activity. From the extract, we isolated a new diterpene rengyonoic acid (1) along with 19 known compounds including two diterpene (2 and 3), three triterpenes (4-6), seven lignans (7-13), two flavonoids (14 and 15), four phenylethanoids (16-19), and an aromatic compound (20). The structure of the new compound (1), including its absolute stereochemistry, was determined based on chemical and physicochemical evidence derived from NMR and MS spectrometry analysis as well as by comparing experimental and predicted ECD data. Among the isolates, 1 (IC50 = 117 μM), pinoresinol (7, 27.9 μM), forsythiaside A (16, 18.6 μM), and suspensaside A (19, 31.1 μM) exhibited β-glucuronidase inhibitory activity equivalent to that of a positive compound, D-saccharic 1,4-lactone (38.6 μM).","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148597436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0