{"title":"前所未有的具有抗炎活性的三萜。","authors":"Ya-feng Wang, Pei-de Tang, Rui-jie He, Zhang-bin Liu, Yong-qiong Wei, Jun Ruan, Bing-yuan Yang, Yong-lin Huang","doi":"10.1007/s11418-025-01936-0","DOIUrl":null,"url":null,"abstract":"<div><p>Four triterpenes with the unprecedented pentacyclic skeletons were isolated from <i>Limax maximus</i>, the traditional medicine of the Zhuang ethnic group in Guangxi. Notably, compounds <b>1</b>−<b>4</b> were characterized by rare 7/6/5 tricyclic ring moiety linked to 6/5 bicyclic moiety via three carbon chain. The structures of compounds <b>1</b>−<b>4</b> were elucidated by comprehensive spectroscopic analysis. The absolute configurations of compounds <b>1</b>−<b>2</b> were determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Biogenetically, compound <b>1</b> could be derived from the tetraepoxysqualenes, via cyclisation and hydroxylation reactions. Bioactivity assay results showed that compound <b>4</b> significantly inhibited LPS-induced NO production in RAW 264.7 cells at 25 µM with inhibition of NO production by 47%.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"79 5","pages":"1216 - 1225"},"PeriodicalIF":2.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unprecedented triterpenes with anti-inflammatory activity from Limax maximus\",\"authors\":\"Ya-feng Wang, Pei-de Tang, Rui-jie He, Zhang-bin Liu, Yong-qiong Wei, Jun Ruan, Bing-yuan Yang, Yong-lin Huang\",\"doi\":\"10.1007/s11418-025-01936-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Four triterpenes with the unprecedented pentacyclic skeletons were isolated from <i>Limax maximus</i>, the traditional medicine of the Zhuang ethnic group in Guangxi. Notably, compounds <b>1</b>−<b>4</b> were characterized by rare 7/6/5 tricyclic ring moiety linked to 6/5 bicyclic moiety via three carbon chain. The structures of compounds <b>1</b>−<b>4</b> were elucidated by comprehensive spectroscopic analysis. The absolute configurations of compounds <b>1</b>−<b>2</b> were determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Biogenetically, compound <b>1</b> could be derived from the tetraepoxysqualenes, via cyclisation and hydroxylation reactions. Bioactivity assay results showed that compound <b>4</b> significantly inhibited LPS-induced NO production in RAW 264.7 cells at 25 µM with inhibition of NO production by 47%.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":654,\"journal\":{\"name\":\"Journal of Natural Medicines\",\"volume\":\"79 5\",\"pages\":\"1216 - 1225\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11418-025-01936-0\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Medicines","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11418-025-01936-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Unprecedented triterpenes with anti-inflammatory activity from Limax maximus
Four triterpenes with the unprecedented pentacyclic skeletons were isolated from Limax maximus, the traditional medicine of the Zhuang ethnic group in Guangxi. Notably, compounds 1−4 were characterized by rare 7/6/5 tricyclic ring moiety linked to 6/5 bicyclic moiety via three carbon chain. The structures of compounds 1−4 were elucidated by comprehensive spectroscopic analysis. The absolute configurations of compounds 1−2 were determined by single-crystal X-ray diffraction analysis using Cu Kα radiation. Biogenetically, compound 1 could be derived from the tetraepoxysqualenes, via cyclisation and hydroxylation reactions. Bioactivity assay results showed that compound 4 significantly inhibited LPS-induced NO production in RAW 264.7 cells at 25 µM with inhibition of NO production by 47%.
期刊介绍：
The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers:
-chemistry of natural products
-biochemistry of medicinal plants
-pharmacology of natural products and herbs, including Kampo formulas and traditional herbs
-botanical anatomy
-cultivation of medicinal plants.
The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.
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