Drimane sesquiterpenoids from cultures of basidiomycete Ganoderma subresinosum

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2025-07-07 DOI:10.1007/s11418-025-01931-5

Arunrat Yangchum, Malipan Sappan, Wilunda Choowong, Tuksaporn Thummarukcharoen, Thitiya Boonpratuang, Masahiko Isaka, Prapairat Seephonkai

引用次数: 0

Abstract

Nine previously undescribed drimane sesquiterpenoids, ganoresinosins A–I (1–9), were isolated from cultures of basidiomycete Ganoderma subresinosum. The absolute configuration of ganoresinosin H (8) was determined using the modified Mosher’s method. Ganoresinosin A (1) showed antimalarial activity against Plasmodium falciparum K1 (IC₅₀ 34 μM), whereas ganoresinosin E (5) exhibited antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC 12.5 μg/mL).

Graphical abstract

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从担子菌灵芝培养物中提取倍半萜类化合物。

从担子菌灵芝亚树脂培养物中分离出9个先前未被描述的驱动型倍半萜类化合物，ganoresinosins A-I（1-9）。用改良的Mosher法测定甘诺树脂蛋白H(8)的绝对构型。Ganoresinosin A(1)对恶性疟原虫K1具有抗疟活性（IC50为34 μM）， Ganoresinosin E(5)对结核分枝杆菌H37Ra具有抗结核活性（MIC为12.5 μg/mL）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.