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Journal of Natural Medicines最新文献

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Apoptosis- and ferroptosis-inducing activity of triptolide in SBC-3 human small-cell lung cancer cells. 雷公藤甲素对SBC-3型人小细胞肺癌细胞凋亡和铁中毒的诱导活性。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-21 DOI: 10.1007/s11418-026-02032-7
Tomoki Iguchi, Yoshihiro Mimaki
{"title":"Apoptosis- and ferroptosis-inducing activity of triptolide in SBC-3 human small-cell lung cancer cells.","authors":"Tomoki Iguchi, Yoshihiro Mimaki","doi":"10.1007/s11418-026-02032-7","DOIUrl":"https://doi.org/10.1007/s11418-026-02032-7","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Processed phellodendri Chinensis cortex attenuates diabetic nephropathy via ferroptosis inhibition through GPX4/SLC7A11/Nrf2/HO-1 signaling pathway. 黄檗皮质加工通过GPX4/SLC7A11/Nrf2/HO-1信号通路抑制铁下垂减轻糖尿病肾病。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-21 DOI: 10.1007/s11418-026-02042-5
Yue Zhou, Gui Xu, Wenjing Ren, Yang Chen, Shiru Jiang, Shuo Zhang, Xiutong Ge, Hui Gao, Fan Zhang
{"title":"Processed phellodendri Chinensis cortex attenuates diabetic nephropathy via ferroptosis inhibition through GPX4/SLC7A11/Nrf2/HO-1 signaling pathway.","authors":"Yue Zhou, Gui Xu, Wenjing Ren, Yang Chen, Shiru Jiang, Shuo Zhang, Xiutong Ge, Hui Gao, Fan Zhang","doi":"10.1007/s11418-026-02042-5","DOIUrl":"https://doi.org/10.1007/s11418-026-02042-5","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota mediates the antidepressant-like effects of xiaochaihutang: mechanisms involving inhibition of inflammation and enhancement of barrier function. 肠道菌群介导小柴胡汤抗抑郁样作用：抑制炎症和增强屏障功能的机制
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-20 DOI: 10.1007/s11418-026-02037-2
Jie Pang, Xingjiao Ma, Nian Hong, Zheng Shen, Shile Li, Xinwei Li, Shasha Wang, Huan Cong, Kuo Zhang, Jingyu Yang, Chunfu Wu
{"title":"Gut microbiota mediates the antidepressant-like effects of xiaochaihutang: mechanisms involving inhibition of inflammation and enhancement of barrier function.","authors":"Jie Pang, Xingjiao Ma, Nian Hong, Zheng Shen, Shile Li, Xinwei Li, Shasha Wang, Huan Cong, Kuo Zhang, Jingyu Yang, Chunfu Wu","doi":"10.1007/s11418-026-02037-2","DOIUrl":"https://doi.org/10.1007/s11418-026-02037-2","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monocarpinensis A-B: two novel cycloartane triterpenoids isolated from Monocarpia kalimantanensis and their medicinal evaluation. Monocarpinensis A-B：从kalimantantensis中分离的两个新的环artane三萜及其药用价值。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-10 DOI: 10.1007/s11418-026-02027-4
Fahriani Istiqamah, Wahyu Safriansyah, Endang Juliansyah, Sari Purbaya, Fajar Fauzi Abdullah, Rustaman Rustaman, Josephine Elizabeth Siregar, Hadi Kuncoro, Kai Oppel, Ronny Lesmana, Yudha Prawira Budiman, Unang Supratman
{"title":"Monocarpinensis A-B: two novel cycloartane triterpenoids isolated from Monocarpia kalimantanensis and their medicinal evaluation.","authors":"Fahriani Istiqamah, Wahyu Safriansyah, Endang Juliansyah, Sari Purbaya, Fajar Fauzi Abdullah, Rustaman Rustaman, Josephine Elizabeth Siregar, Hadi Kuncoro, Kai Oppel, Ronny Lesmana, Yudha Prawira Budiman, Unang Supratman","doi":"10.1007/s11418-026-02027-4","DOIUrl":"https://doi.org/10.1007/s11418-026-02027-4","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated network pharmacology and pharmacological evaluation to elucidate the effect and mechanism of the novel combination PMS in treatment of osteoporosis. 结合网络药理学和药理学评价，阐明新型联合PMS治疗骨质疏松症的疗效和机制。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-04-02 DOI: 10.1007/s11418-025-01973-9
Qingchang Wu, Yachen Wang, Lijin Yang, Runcong Dong, Yuxu Xie
{"title":"Integrated network pharmacology and pharmacological evaluation to elucidate the effect and mechanism of the novel combination PMS in treatment of osteoporosis.","authors":"Qingchang Wu, Yachen Wang, Lijin Yang, Runcong Dong, Yuxu Xie","doi":"10.1007/s11418-025-01973-9","DOIUrl":"https://doi.org/10.1007/s11418-025-01973-9","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in progress of natural anticoagulant active substances. 天然抗凝血活性物质研究进展。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-03-29 DOI: 10.1007/s11418-026-02013-w
Meilian Zhong, Xiao Liu, Juting Liao, Yang Zhang, Youbin Li, Shuojin Wang
{"title":"Recent advances in progress of natural anticoagulant active substances.","authors":"Meilian Zhong, Xiao Liu, Juting Liao, Yang Zhang, Youbin Li, Shuojin Wang","doi":"10.1007/s11418-026-02013-w","DOIUrl":"https://doi.org/10.1007/s11418-026-02013-w","url":null,"abstract":"<p><p>Thrombotic diseases pose a serious threat to human life and health. Anticoagulant drugs are used to treat and prevent thrombotic diseases. However, although the anticoagulant drugs currently used in clinical practice are effective, they have limitations such as narrow therapeutic window and high risk of bleeding. Therefore, the development of new safe and effective anticoagulants based on natural products and their structural modifications has become an important research direction to overcome the current treatment bottlenecks in this field. In this paper, \"thrombotic diseases\", \"anticoagulant-active molecules\", \"natural products\" and \"structural modifications\" were used as keywords to search the research data on anticoagulant-active molecules published in the past decade in PubMed, Web of Science, ScienceDirect, Google Scholar and CNKI databases. The research progress of anticoagulant- active molecules from animals and plants was reviewed, which provide basic data for promoting the development of innovative anticoagulant drugs. In this paper, the classification of thrombotic diseases and the clinical drugs currently used in clinical practice are reviewed. Next, the coagulation mechanism and the fact that an imbalance between coagulation and anticoagulation in vivo can lead to thrombosis are described. Finally, the research reports on anticoagulant active compounds and their structural modifications from plants and animals in the past 10 years are summarized. A total of 68 anticoagulant molecules were identified, which provide an important direction and candidate molecules for the development of new, efficient and low-risk anticoagulant drugs.</p>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-asthmatic effects and ingredient annotation of the active fraction from Ganoderma lucidum. 灵芝有效部位的平喘作用及成分注释。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-03-26 DOI: 10.1007/s11418-025-01978-4
Ning Li, Qian He, Cunwu W Chen, Qun Zhao, Yanfei F He
{"title":"Anti-asthmatic effects and ingredient annotation of the active fraction from Ganoderma lucidum.","authors":"Ning Li, Qian He, Cunwu W Chen, Qun Zhao, Yanfei F He","doi":"10.1007/s11418-025-01978-4","DOIUrl":"https://doi.org/10.1007/s11418-025-01978-4","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of extraction methods on the phase, composition, bacteriostatic effect of Radix Scutellariae-Rhizoma Coptidis decoction. 提取方法对黄芩-黄连汤物相、成分及抑菌效果的影响。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-03-21 DOI: 10.1007/s11418-026-02019-4
Mei Zhang, Miaomiao Wei, Xiaolu Liu, Ruihua Qi, Min Li, Yunhong Wang, Junxuan Yang, Xiumei Ke
{"title":"Effects of extraction methods on the phase, composition, bacteriostatic effect of Radix Scutellariae-Rhizoma Coptidis decoction.","authors":"Mei Zhang, Miaomiao Wei, Xiaolu Liu, Ruihua Qi, Min Li, Yunhong Wang, Junxuan Yang, Xiumei Ke","doi":"10.1007/s11418-026-02019-4","DOIUrl":"https://doi.org/10.1007/s11418-026-02019-4","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological activity of isomalabaricane compounds from the marine sponge Rhabdastrella globostellata. 海绵体中异马拉巴拉烷类化合物的生物活性研究。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-03-21 DOI: 10.1007/s11418-026-02030-9
Ekaterina A Yurchenko, Anastasia B Kozhushnaya, Sophia A Kolesnikova, Ekaterina A Chingizova, Ekaterina S Menchinskaya, Evgeny A Pislyagin, Aleksandra S Kuzmich, Dmitry L Aminin
{"title":"Biological activity of isomalabaricane compounds from the marine sponge Rhabdastrella globostellata.","authors":"Ekaterina A Yurchenko, Anastasia B Kozhushnaya, Sophia A Kolesnikova, Ekaterina A Chingizova, Ekaterina S Menchinskaya, Evgeny A Pislyagin, Aleksandra S Kuzmich, Dmitry L Aminin","doi":"10.1007/s11418-026-02030-9","DOIUrl":"https://doi.org/10.1007/s11418-026-02030-9","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mechanism of the water layer extract of Cichorium pumilum Jacq water extract in the treatment of Hepatic fibrosis was investigated using HPLC-MS/MS and network pharmacology. 采用高效液相色谱-质谱联用和网络药理学的方法，研究菊苣水提物水层提取物治疗肝纤维化的作用机制。
IF 2.5 4区 医学
Journal of Natural Medicines Pub Date : 2026-03-21 DOI: 10.1007/s11418-026-02024-7
Weijun Chen, Nuan Dong, Xue Lu, Dongmei Qin
{"title":"The mechanism of the water layer extract of Cichorium pumilum Jacq water extract in the treatment of Hepatic fibrosis was investigated using HPLC-MS/MS and network pharmacology.","authors":"Weijun Chen, Nuan Dong, Xue Lu, Dongmei Qin","doi":"10.1007/s11418-026-02024-7","DOIUrl":"https://doi.org/10.1007/s11418-026-02024-7","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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