Journal of Natural Medicines最新文献_第2页

Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity. 从海洋真菌 Didymella aeria 中分离出的芳香族多酮化合物及其神经保护活性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-11-08 DOI: 10.1007/s11418-024-01858-3

Hitoshi Kamauchi, Mayu Tanaka, Kakeru Koyama, Yuka Kiba, Masashi Kitamura, Yoshiaki Sugita

引用次数: 0

3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells. 3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide（一种来自青蒿的倍半萜）可通过 NF-κB/MAPK 通路减轻脂多糖诱导的炎症反应，并通过 ROS 通路减轻 RAW264.7 细胞的氧化应激反应。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-11-05 DOI: 10.1007/s11418-024-01854-7

Qianqian Ren, Lili Wang, Xin Wang, Xiaoran Min, Xiling Dai, Guozheng Huang, Jianguo Cao

{"title":"3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells.","authors":"Qianqian Ren, Lili Wang, Xin Wang, Xiaoran Min, Xiling Dai, Guozheng Huang, Jianguo Cao","doi":"10.1007/s11418-024-01854-7","DOIUrl":"https://doi.org/10.1007/s11418-024-01854-7","url":null,"abstract":"Inflammation is a vital and normal physiological response; however, excessive inflammation can contribute to the development of various diseases. Artemisia sieversiana, a traditional Chinese medicinal plant, contains a variety of chemical compounds. One such compound, 3-oxo-11αH-germacra-1(10)E,4Z-dien-12,6α-olide, a germacranolide sesquiterpenoid (germacranolide, GMO), has not been thoroughly investigated regarding its potential anti-inflammatory properties. In this study, the anti-inflammatory and antioxidant properties of GMO were investigated for the lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells. It was demonstrated that GMO effectively suppressed the production of inflammatory mediators, decreased the phosphorylation of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) in RAW264.7 cells. Additionally, GMO exhibited the capacity to mitigate oxidative damage induced by LPS, as indicated by assessments of reactive oxygen species and mitochondrial membrane potential. In summary, GMO possesses significant anti-inflammatory effects by modulating the NF-κB/MAPK pathway and antioxidant effects by regulating ROS production.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain. 不含麻黄碱的麻黄草提取物对紫杉醇诱导的神经性疼痛的预防和治疗作用

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-10-29 DOI: 10.1007/s11418-024-01853-8

Xuedan Huang, Sumiko Hyuga, Michiho Ito, Yukihiro Goda, Yoshinori Kobayashi

{"title":"Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain.","authors":"Xuedan Huang, Sumiko Hyuga, Michiho Ito, Yukihiro Goda, Yoshinori Kobayashi","doi":"10.1007/s11418-024-01853-8","DOIUrl":"https://doi.org/10.1007/s11418-024-01853-8","url":null,"abstract":"Currently, there are no effective prophylactic or therapeutic drugs for the treatment of paclitaxel (PTX)-induced peripheral neuropathic pain (PTX-PNP), highlighting the urgent need for the development of effective prophylactic and therapeutic drugs. In this study, we initially compared the efficacy of Ephedra Herb extract (EHE) with that of ephedrine alkaloids-free Ephedra Herb extract (EFE), which lacked ephedrine alkaloids (EAs)-associated side effects, against the onset of PTX-induced mechanical allodynia, thermal hyperalgesia, and cold allodynia in mice. EHE and EFE demonstrated comparable preventive effects on the PTX-PNP in a dose-dependent manner. These results indicated that the preventive properties of EHE were independent of the EAs. Since elderly people are overwhelmingly more susceptible to developing cancer, we considered that EFE has greater benefits than EHE, so we conducted a study focused on the effects of EFE. EFE showed dose-dependent preventive effects on the onset of PTX-PNP. As a result of detailed investigation, coadministration of PTX and EFE (Co-EFE) was more effective than preadministration of EFE alone (Pre-EFE). And the effects of Co-EFE was same with the effect of preadministration of EFE and then coadministration of PTX and EFE (P&C-EFE). Additionally, Co-EFE after the onset of PTX-PNP improved PTX-induced mechanical allodynia, thermal hyperalgesia, and cold allodynia, confirming the therapeutic efficacy of EFE on PTX-PNP. In contrast, goshajinkigan, a Kampo medicine, and diclofenac, a non-steroidal anti-inflammatory drug, showed minimal therapeutic effects on PTX-PNP. These findings demonstrate the significant potential of EFE as a novel, safe prophylactic and therapeutic agent against PTX-PNP.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the inhibitory activity and mechanism on lipid production in 3T3-L1 cells by hot water extract derived from Acacia confusa flowers. 探索金合欢花热水提取物对 3T3-L1 细胞脂质生成的抑制活性和机制

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-10-29 DOI: 10.1007/s11418-024-01856-5

Nai-Wen Tsao, Ju-Ya Cheng, Sheng-Yang Wang

{"title":"Exploring the inhibitory activity and mechanism on lipid production in 3T3-L1 cells by hot water extract derived from Acacia confusa flowers.","authors":"Nai-Wen Tsao, Ju-Ya Cheng, Sheng-Yang Wang","doi":"10.1007/s11418-024-01856-5","DOIUrl":"https://doi.org/10.1007/s11418-024-01856-5","url":null,"abstract":"Acacia confusa Merr. (Fabaceae) (A. confusa) is a native tree species of Taiwan, commonly found in the low-altitude mountains and hilly areas of the Hengchun Peninsula. This evergreen, perennial, and large-sized tree was the focus of a study that employed various chromatographic and spectroscopic methods to analyze the hot water extract of its flowers. The analysis revealed that the major components of the extract were myricitrin, quercitrin, europetin-3-O-rhamnoside, and chalconaringenin-2'-xyloside, with respective concentrations of approximately 0.22, 0.02, 0.26, and 0.10 mg/g of the flowers. Subsequent cell assays were conducted to assess the inhibitory effect of the extract on lipid synthesis in fat cells. Oil Red O staining results indicated that the extract significantly suppressed fatty acid accumulation in 3T3-L1 cells, with the most pronounced effect observed at a concentration of 180 μg/ml. Furthermore, the hot water extract of A. confusa flowers was found to increase the phosphorylation of AMP-activated protein kinase (AMPK), decrease the phosphorylation of cAMP response element-binding protein (CREB), and reduce the expression of glucocorticoid receptor (GR) protein. This, in turn, inhibited the expression of downstream transcription factors such as CCAT/ehancer binding proteins α (C/EBPα), CCAT/ehancer binding proteins β (C/EBPβ), CCAT/ehancer binding proteins δ (C/EBPδ), peroxisome proliferation-actived receptor γ (PPARγ), and sterol regulatory element binding proteins-1 (SREBP-1). Consequently, the expression of lipid synthesis-related proteins acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and fatty acid translocase (CD36) was reduced, ultimately inhibiting lipid generation. Therefore, the hot water extract of A. confusa flowers shows potential for development as a weight-loss tea.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway. 杜仲皮提取物通过 TGF-β1/Smad 信号通路缓解腺嘌呤诱导的慢性肾功能衰竭小鼠肾脏纤维化。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-10-24 DOI: 10.1007/s11418-024-01848-5

Wenyi Jiang, Zhengyou He, Ruijiao Yao, Wenyan Xiao, Zhiyang Chen, Xia Zeng, Miao Zheng, Jing Wang, Jia Li, Yong Jiang

引用次数: 0

Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity. 白花蛇舌草中的甲氧基黄酮葡萄糖苷和咖啡酰苯乙醇苷：其结构和抗败血病活性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-10-23 DOI: 10.1007/s11418-024-01851-w

Rena Takizawa, Tomoyo Minamizono, Daisuke Tsuji, Xiao-Jie Yan, Feng-Lai Lu, Xue-Rong Yang, Dian-Peng Li, Reiko Akagi, Yoshiki Kashiwada, Naonobu Tanaka

引用次数: 0

New sesquiterpenes from the soft coral Litophyton arboreum. 来自软珊瑚 Litophyton arboreum 的新倍半萜。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-10-22 DOI: 10.1007/s11418-024-01843-w

Amany Hamouda Mahmoud, Sabry A H Zidan, Mamdouh Nabil Samy, Abdallah Alian, Mahmoud A A Ibrahim, Mostafa Ahmed Fouad, Mohamed Salah Kamel, Katsuyoshi Matsunami

{"title":"New sesquiterpenes from the soft coral Litophyton arboreum.","authors":"Amany Hamouda Mahmoud, Sabry A H Zidan, Mamdouh Nabil Samy, Abdallah Alian, Mahmoud A A Ibrahim, Mostafa Ahmed Fouad, Mohamed Salah Kamel, Katsuyoshi Matsunami","doi":"10.1007/s11418-024-01843-w","DOIUrl":"https://doi.org/10.1007/s11418-024-01843-w","url":null,"abstract":"Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were isolated from the soft coral Litophyton arboreum, together with nine known ones, including five sesquiterpenes; 11-hydroxy-8-oxo-β-cyperon (1), alismoxide (4), 5β,8β-epidioxy-11-hydroxy-6-eudesmene (5), chabrolidione B (6), 7-oxo-tri-nor-eudesm-5-en-4β-ol (7), two sterols; 7β-acetoxy-24-methyl-cholesta-5,24(28)-diene-3β,19-diol (8), nebrosteroid M (9), and two glycerol derivatives; chimyl alcohol (10) and batyl alcohol (11). The structures of the isolated compounds were characterized using spectroscopic techniques, predominately HR-ESI-MS, 1D, 2D-NMR, and ECD analyses. Compounds 1-11 were evaluated for their cytotoxic activity against three human cancer-cell lines (A549, MCF-7 and HepG2), and anti-leishmanial potential against the causal parasite, Leishmania major. Compounds 4, 8, and 9 exhibited potent cytotoxic activity against the A549 cell line (IC50 = 17.0 ± 2.5, 13.5 ± 2.1, and 16.5 ± 1.3 μg/ml, respectively) as compared with the standard antitumor agent etoposide (IC50 28.4 ± 4.5 μg/ml). In addition, compound 9 exhibited remarkable cytotoxic activity against MCF-7 cell line (IC50 = 24.7 ± 2.1 μg/ml: 22.2 ± 4.2 μg/mL for etoposide).","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation. 通过抑制 NLRP3 炎症小体的活化，防止多柔比星诱发的心脏毒性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-10-22 DOI: 10.1007/s11418-024-01850-x

Hao Zhang, Xiaoyun Ding, Yumei Qiu, Mengdie Xie, Hu Wang, Tingting Li, Huiyun Bao, Si Huang, Yinhua Xiong, Xilan Tang

{"title":"Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation.","authors":"Hao Zhang, Xiaoyun Ding, Yumei Qiu, Mengdie Xie, Hu Wang, Tingting Li, Huiyun Bao, Si Huang, Yinhua Xiong, Xilan Tang","doi":"10.1007/s11418-024-01850-x","DOIUrl":"https://doi.org/10.1007/s11418-024-01850-x","url":null,"abstract":"Cardiotoxicity is one of the major obstacles to anthracycline chemotherapy. Anthracycline cardiotoxicity is closely associated with inflammation. Imperatorin (IMP), a furocoumarin ingredient extracted from Angelica dahurica, might have potential activity in preventing anthracycline cardiotoxicity due to its anti-cancer, anti-inflammatory, anti-oxidant, cardioprotective properties. This study aims to reveal the effect of IMP on doxorubicin (DOX)-induced cardiotoxicity and its underlying mechanism. We established a rat model of DOX-induced cardiotoxicity by intraperitoneal injection with DOX (1.25 mg/kg twice weekly for 6 weeks), and found that both IMP (25 mg/kg and 12.5 mg/kg) and dexrazoxane 12.5 mg/kg relieved DOX-induced reductions in heart weight, change in cardiac histopathology, and elevated serum levels of LDH, AST and CK-MB. Moreover, DOX upregulated mRNA levels of NLRP3, CASP1, GSDMD, ASC, IL-1β and IL-18, elevated protein expressions of NLRP3, ASC, GSDMD-FL, GSDMD-N, pro‑caspase‑1, caspase‑1 p20, pro‑IL‑1β and IL‑1β in heart tissues, as well as increased serum levels of pro-inflammatory cytokines including IL-1β and IL-18, however both of IMP and dexrazoxane suppressed these alterations. In addition, we carried out neonatal rat cardiomyocytes experiments to confirm the results of the in vivo study. Consistently, pretreatment with IMP 25 µg/mL relieved DOX (1 μg/mL)-induced cardiomyocytes injury, including decreased cell viability and reduced supernatant LDH. IMP inhibited DOX-induced activation of NLRP3 inflammasome in cardiomyocytes. In conclusion, IMP had a protective effect against DOX-induced cardiotoxicity via repressing the activation of NLRP3 inflammasome. These findings suggest that IMP may be a promising alternative or adjunctive drug for the prevention of anthracycline cardiotoxicity.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability. 当归酸通过靶向和损害 NRF2 蛋白的稳定性引发结直肠癌细胞的铁变态反应

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-10-21 DOI: 10.1007/s11418-024-01849-4

Yongyi Cao, Yu Wang, Yueyang Li, Sihan Liu, Lizhe Wang, Li Zhou, Ting Zhu

{"title":"Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability.","authors":"Yongyi Cao, Yu Wang, Yueyang Li, Sihan Liu, Lizhe Wang, Li Zhou, Ting Zhu","doi":"10.1007/s11418-024-01849-4","DOIUrl":"https://doi.org/10.1007/s11418-024-01849-4","url":null,"abstract":"Ferroptosis is a unique programmed cell death driven by iron-dependent phospholipid peroxidation. Tumor cells that escape from the conventional therapies appear more sensitive to ferroptosis. Therefore, it is extremely urgent to find safe and efficient active ingredients that induce ferroptosis in tumor cells. Herein, we identified that angelic acid, as a potent anti-tumor active ingredient in Angelica sinensis, profoundly sensitizes CRC cells to ferroptosis via a natural compound library screen. We revealed that angelic acid treatment is sufficient to predispose CRC cells to ferroptosis phenotype, evidenced by malondialdehyde (MDA) accumulation, lipid peroxidation, and upregulation of ferroptosis-associated markers CHAC1 and PTGS2, which is abolished by ferroptosis inhibitor Fer-1. Moreover, the results of network pharmacology showed that NRF2 is critical for angelic acid-mediated CRC cell ferroptosis. Mechanistically, angelic acid exerted its ferroptosis induction via directly binding and facilitating the degradation of NRF2. In addition, the syngeneic mouse models revealed that angelic acid boosts CRC cell sensitivity to ferroptosis inducer sulfasalazine with essentially no toxicity in vivo. Collectively, our findings highlighted a previously unrecognized anti-tumor mechanism of angelic acid and represented an appealing therapeutic strategy for CRC treatment.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation. 马尾藻中七种未曾描述过的 Meroterpenoids 及其对淀粉样蛋白 β 聚集的抑制活性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2024-10-15 DOI: 10.1007/s11418-024-01847-6

Mitsuhiro Sekiguchi, Mafumi Horiuchi, Yuta Tozawa, Hideyuki Shigemori

引用次数: 0