Journal of Natural Medicines最新文献_第2页

Amide and phenylpropanoid glycosides from the fruits of Piper longum L. and their anti-inflammatory activity. 胡椒果实中的酰胺类和苯丙类苷及其抗炎活性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-25 DOI: 10.1007/s11418-025-01893-8

Guanghui Gou, Liu Liu, Wenli Bao, Jun Li, Haji Akber Aisa

引用次数: 0

Extraction, characterization, and biological activities of a novel polysaccharide extract from Fructus caryophylli. 一种新型石竹多糖提取物的提取、表征及生物活性研究。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-23 DOI: 10.1007/s11418-025-01891-w

Qingtao Yu, Wenzhi Li, Jieyi Long, Ming Liang, Lingli Jiang, Xiaoliang Lin, Dongqing He, Zhuoyan Wu, Xiaole Xia

{"title":"Extraction, characterization, and biological activities of a novel polysaccharide extract from Fructus caryophylli.","authors":"Qingtao Yu, Wenzhi Li, Jieyi Long, Ming Liang, Lingli Jiang, Xiaoliang Lin, Dongqing He, Zhuoyan Wu, Xiaole Xia","doi":"10.1007/s11418-025-01891-w","DOIUrl":"https://doi.org/10.1007/s11418-025-01891-w","url":null,"abstract":"This study showed that Polysaccharide-rich Fructus caryophylli extracts (FCE) were prepared for investigation through hot water extraction. Glucose was found to be the significant monosaccharide by chemical analysis, which included Fourier transform-infrared (FT-IR), high-performance liquid chromatography (HPLC), and high-performance gel permeation chromatography (HPGPC). The average molecular weight of FCE was ranged from 15.19 and 208.53 kDa. The bioactivities of FCE, including antioxidant, whitening, tissue regeneration, and anti-wrinkle properties, were evaluated using both in vitro and in vivo tests. In vitro antioxidant experiments demonstrated scavenging of 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), hydroxyl radicals, and strong reducing power. FCE treatment effectively reduced oxidative stress in an in vivo antioxidant experiment involving zebrafish embryos exposed to a nonlethal dose of LPS, demonstrating its potent antioxidant potential. Furthermore, FCE exhibited promise in decreasing tyrosinase activity and total melanin content in zebrafish embryos, while promoting the relative expression levels of the elastin-regulating gene Eln1 RNA and the collagen-related gene col1a1a, thereby facilitating the positive stimulation of wound healing. This research provides valuable insights into the development of FCE as a novel functional raw material for applications in the food and cosmetics industries.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in Aconitum japonicum. 多组学分析揭示了日本乌头中二萜生物碱的组织特异性生物合成和积累。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-20 DOI: 10.1007/s11418-025-01881-y

Megha Rai, Amit Rai, Tetsuya Mori, Ryo Nakabayashi, Michimi Nakamura, Marsheige Kojoma, Hideyuki Suzuki, Kazuki Saito, Mami Yamazaki

{"title":"Multi-omics analysis reveals tissue-specific biosynthesis and accumulation of diterpene alkaloids in Aconitum japonicum.","authors":"Megha Rai, Amit Rai, Tetsuya Mori, Ryo Nakabayashi, Michimi Nakamura, Marsheige Kojoma, Hideyuki Suzuki, Kazuki Saito, Mami Yamazaki","doi":"10.1007/s11418-025-01881-y","DOIUrl":"https://doi.org/10.1007/s11418-025-01881-y","url":null,"abstract":"Aconitum japonicum, native to the mountainous regions of Japan, is a toxic perennial plant widely recognized for its therapeutic potential. Despite its pharmacological importance, the complete biosynthetic pathway of diterpene alkaloids, bioactive compounds with significant pharmaceutical implications and derived from Aconitum species, remains elusive. In this study, leveraging high-throughput metabolome and transcriptome analyses, we conducted a comprehensive investigation using four tissues of A. japonicum, including leaf, mother root, daughter root, and rootlet. By integrating these multi-omics datasets, we achieved a holistic insight into the gene expression patterns and metabolite profiles intricately linked with diterpene alkaloid biosynthesis. Our findings unveil potential regulatory networks and pinpoint key candidate genes pivotal in diterpene alkaloid synthesis. Through comparative analyses across tissues, we delineate tissue-specific variations in gene expression and metabolite accumulation, shedding light on the spatial regulation of these biosynthetic pathways within the plant. Furthermore, this study contributes to a deeper understanding of the molecular mechanisms dictating the production of diterpene alkaloids in A. japonicum. Besides advancing our knowledge of plant secondary metabolism in A. japonicum, this study also provides a high-quality multi-omics resource for future studies aimed at functionally characterizing the target genes involved in different metabolic processes.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between the metabolic profile of Nelumbo Seed, a component of Seishinrenshiin, and its inhibitory activity on bladder smooth muscle contraction. 参参仁心素成分莲子代谢谱与膀胱平滑肌收缩抑制活性的相关性研究。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-19 DOI: 10.1007/s11418-025-01889-4

Kazuo Harada, Yuki Fukuda, Takahiro Ohkubo, Kimio Sugaya, Yukihiko Osaki

{"title":"Correlation between the metabolic profile of Nelumbo Seed, a component of Seishinrenshiin, and its inhibitory activity on bladder smooth muscle contraction.","authors":"Kazuo Harada, Yuki Fukuda, Takahiro Ohkubo, Kimio Sugaya, Yukihiko Osaki","doi":"10.1007/s11418-025-01889-4","DOIUrl":"https://doi.org/10.1007/s11418-025-01889-4","url":null,"abstract":"Seishinrenshiin (SRI), a Kampo formula, is often used for frequent urination. Nelumbo Seed, a crude-drug component of SRI was reported to inhibit bladder smooth muscle contraction using excised rat bladder tissues. However, the active ingredients of Nelumbo Seed have not yet been identified. In this study, we investigated the active ingredients of Nelumbo Seed that inhibit bladder smooth muscle contraction. We obtained liquid chromatography/mass spectrometry profiles of extracts prepared from five types of Nelumbo Seed materials from different production areas and evaluated their inhibitory effects on excised rat bladder smooth muscle contraction. Analysis of these data using orthogonal projections to latent structures revealed neferine (Nef) as the compound with the highest variable influence on projection. Among the Nelumbo Seed materials processed using different methods, the Nef content was the highest in 'Sekirenshi', when embryo and pericarp were not removed at all. We determined the effects of administering Nelumbo Seed extracts with different Nef content on frequent-urination model rats. The Nef content in rat plasma was the highest when the Sekirenshi extract was administered, but Nef was not detected when seed embryos were removed. In this model, administration of the Nelumbo Seed extract improved the maximum bladder contraction pressure and bladder contraction interval, albeit not significantly. In particular, Sekirenshi tended to reduce the maximum bladder contraction pressure compared to other Nelumbo Seed. Our results indicate that although Nef in Nelumbo Seed does not clearly improve frequent urination, it might contribute to the improvement of urination disorder.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New oxepin and dihydrobenzofuran derivatives from Bauhinia saccocalyx roots and their anti-inflammatory, cytotoxic, and antioxidant activities. 从洋紫荆根中提取的新氧杂卓素和二氢苯并呋喃衍生物及其抗炎、细胞毒性和抗氧化活性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-14 DOI: 10.1007/s11418-025-01888-5

Lueacha Tabtimmai, Thanyathon Phonchan, Natrinee Thongprik, Sutin Kaennakam, Nuttapon Yodsin, Kiattawee Choowongkomon, Chanikan Sonklin, Supachai Jadsadajerm, Awat Wisetsai

{"title":"New oxepin and dihydrobenzofuran derivatives from Bauhinia saccocalyx roots and their anti-inflammatory, cytotoxic, and antioxidant activities.","authors":"Lueacha Tabtimmai, Thanyathon Phonchan, Natrinee Thongprik, Sutin Kaennakam, Nuttapon Yodsin, Kiattawee Choowongkomon, Chanikan Sonklin, Supachai Jadsadajerm, Awat Wisetsai","doi":"10.1007/s11418-025-01888-5","DOIUrl":"https://doi.org/10.1007/s11418-025-01888-5","url":null,"abstract":"Four new oxepin and dihydrobenzofuran derivatives, saccoxepins A-C (1-3) and saccobenzofurin A (4), along with one known compound, bauhinoxepin A (5), were isolated from the roots of Bauhinia saccocalyx. The structures were elucidated by extensive analysis of spectroscopic data in combination with ECD analysis. The EtOAc extract exhibited significant NO inhibition (94.4 ± 0.35%, 50 μg/mL), and saccoxepin A and bauhinoxepin A demonstrated strong NO suppression, with IC50 values of 49.35 µM and 30.28 µM, respectively, alongside notable antioxidant activity. Saccoxepin A and bauhinoxepin A selectively reduced interleukin-6 (IL-6) levels, while bauhinoxepin A slightly lowered tumor necrosis factor-alpha (TNF-α) at a low dose. Furthermore, bauhinoxepin A exhibited cytotoxicity against HCT-116 cells, with an IC50 of 8.88 µM. These findings suggest that the roots of B. saccocalyx possess potent antioxidant, anti-inflammatory, and anticancer activities, supporting its traditional medicinal applications and highlighting its potential as a source of therapeutic agents.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth characteristics, optimal harvest timing, and quality assessment of three Evodia species cultivated in Japan. 日本栽培的三种吴茱萸的生长特性、最佳采收时机及品质评价。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-12 DOI: 10.1007/s11418-025-01886-7

Koji Sugimura, Raju Aedla, Hiroyuki Fuchino, Osamu Iida, Takashi Watanabe

{"title":"Growth characteristics, optimal harvest timing, and quality assessment of three Evodia species cultivated in Japan.","authors":"Koji Sugimura, Raju Aedla, Hiroyuki Fuchino, Osamu Iida, Takashi Watanabe","doi":"10.1007/s11418-025-01886-7","DOIUrl":"https://doi.org/10.1007/s11418-025-01886-7","url":null,"abstract":"Immature Evodia fruits are used in herbal medicine for their analgesic properties; however, determining the appropriate time for harvesting these fruits remains challenging. Here, we investigated the growth characteristics and optimal timing for collecting the immature fruits of three Evodia species-E. rutaecarpa (Juss.) Benth., E. officinalis Dode, and E. hupehensis Dode-cultivated at the Tanegashima Division of the Research Center for Medicinal Plant Resources, Japan. Evodiamine and rutaecarpine content in the three species were measured across different collection seasons, and the relationship between time elapsed from the start of flowering and the levels of these active ingredients was determined. We found that the optimal time to collect the immature fruits of E. officinalis for use in herbal medicine was 2 weeks after flowering, when the fruit was heavier, contained more active ingredients, and had not yet dehisced. E. rutaecarpa fruits were heavier, contained more active ingredients, and retained their color (orange) until 3 weeks post-flowering. This suggests that the optimal collection time varied among species. Overall, E. rutaecarpa was the most suitable species for cultivation in Japan for use in herbal medicines because its optimal collection time was easier to determine, and its pericarp and seeds did not separate during drying. Therefore, to efficiently harvest Evodia fruits, cultivation methods should be optimized to leverage the specific growth characteristics of each species, with particular emphasis on accurately determining the optimal harvest time.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides from the aerial parts of Leptopyrum fumarioides as potential COX-2 inhibitors: in vitro and in silico studies. Leptomonines A和B，两种新的稀有苯四氢异喹啉n -氧化物作为潜在的COX-2抑制剂：体外和硅研究。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-07 DOI: 10.1007/s11418-025-01882-x

Tserendorj Solongo, Tran Thu Huong, Erdenetsogt Purevdorj, Amgalan Solongo, Battsagaan Bayasgalan, Vu Thanh Loc, Nguyen Xuan Ha, Vu Thi Ha, Nguyen Phi Hung, Do Thi Thao, Nguyen Thi Nga, Hai Pham- The, Pauline Stark, Nguyen Manh Cuong

{"title":"Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides from the aerial parts of Leptopyrum fumarioides as potential COX-2 inhibitors: in vitro and in silico studies.","authors":"Tserendorj Solongo, Tran Thu Huong, Erdenetsogt Purevdorj, Amgalan Solongo, Battsagaan Bayasgalan, Vu Thanh Loc, Nguyen Xuan Ha, Vu Thi Ha, Nguyen Phi Hung, Do Thi Thao, Nguyen Thi Nga, Hai Pham- The, Pauline Stark, Nguyen Manh Cuong","doi":"10.1007/s11418-025-01882-x","DOIUrl":"https://doi.org/10.1007/s11418-025-01882-x","url":null,"abstract":"Leptomonines A and B, two novel rare benzyltetrahydroisoquinoline N-oxides, were isolated from the aerial parts of Leptopyrum fumarioides (L.) Reichenb. collected in Tuv province, Mongolia. Their chemical structures, absolute configurations, and conformations were established by 2D-NMR and CD spectral analyses. Leptomonine A (1) can suppress TNF-α production and COX-2 expression in LPS-stimulated RAW 267.4 cells. This compound at a concentration of 100 µM significantly reduced the TNF-α and COX-2 levels by 36.43% and 47.10%, respectively, compared with the negative control. Moreover, leptomonine B (2) remarkably lowers COX-2 levels at the highest concentration. The docking simulations were conducted with the COX-2 enzyme and revealed the binding ability of leptomonine A (1) and leptomonine B (2) with binding energies of - 9.03 and - 8.96 kcal/mol, respectively. The interactions of these alkaloids with the targets were mainly with the hydrophobic and hydrophilic sites, which are quite similar to rofecoxib. Phytochemical investigation revealed the diversity and novelty of the natural isoquinoline alkaloids in Leptopyrum fumarioides. Two new benzyltetrahydroisoquinoline N-oxides were identified as the bioactive constituents of Leptopyrum fumarioides by assessing its anti-inflammatory effects. The findings provide scientific justification to support the traditional application of Leptopyrum fumarioides for treating liver diseases associated with inflammation.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grandifolins A-D: three 6/6/5 abietane diterpenes and an abietane diterpene from Salvia grandifolia. 桔梗苷A-D：三种6/6/5枞烷二萜和一种来自桔梗的枞烷二萜。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-02 DOI: 10.1007/s11418-025-01884-9

Hiroshi Kawabe, Teppei Komiyama, Yoshinori Saito, Yasuko Okamoto, Emi Hara, Keiichi Matsuzaki, Motoo Tori, Ryo Hanai, Hiroshi Hirota, Xun Gong, Chiaki Kuroda, Hiroyuki Kagechika, Ayumi Ohsaki

{"title":"Grandifolins A-D: three 6/6/5 abietane diterpenes and an abietane diterpene from Salvia grandifolia.","authors":"Hiroshi Kawabe, Teppei Komiyama, Yoshinori Saito, Yasuko Okamoto, Emi Hara, Keiichi Matsuzaki, Motoo Tori, Ryo Hanai, Hiroshi Hirota, Xun Gong, Chiaki Kuroda, Hiroyuki Kagechika, Ayumi Ohsaki","doi":"10.1007/s11418-025-01884-9","DOIUrl":"https://doi.org/10.1007/s11418-025-01884-9","url":null,"abstract":"The genus Salvia is a well-established source of biologically active compounds with beneficial health effects. In this study, we aimed to isolate and structurally characterize novel compounds from Salvia grandifolia and evaluate their cytotoxic activity against human promyelocytic leukemia (HL-60) and cervical cancer (HeLa) cell lines. Three new rearranged abietane-type diterpenes, grandifolins A-C (1-3) and a new abietane diterpene, grandifolin D (4), were isolated from the roots of Salvia grandifolia, along with 12 known compounds (5-16). Their structures were determined by combining extensive 1H and 13C spectroscopy, X-ray crystallography, and electronic circular dichroism spectra (ECD). The skeletons of 1-3 had a rearranged structure with a 6/6/5 ring from an abietane-type diterpene. A plausible biosynthetic pathway for the rearranged skeleton was also proposed. Many of the isolated compounds showed weak cytotoxicity against HeLa or HL-60 cell lines.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New abietane-type diterpenoids from roots of Euonymus hamiltonianus and their cytotoxicity in human cancer cell. 哈密卫矛根新发现的二萜及其对人癌细胞的细胞毒性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-03-01 DOI: 10.1007/s11418-025-01887-6

Jungmoo Huh, Eun Jin Park, Jae Hyun Lee, Chan-Woong Park, Tae-Jin Yang, Won Keun Oh, Young-Won Chin

引用次数: 0

Potential α-glucosidase inhibitors from cultures of Biscogniauxia capnodes SWUF15-40 fungus. 双头菌SWUF15-40培养物中潜在的α-葡萄糖苷酶抑制剂。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-26 DOI: 10.1007/s11418-025-01876-9

Audomsak Churat, Praewpan Katrun, Chittima Laohpongspaisan, Wiyada Mongkolthanaruk, Chamaiporn Champasri, Pairot Moontragoon, Nuttika Suwannasai, Ek Sangvichien, Pakarapon Poonsukkho, Sirirath McCloskey

{"title":"Potential α-glucosidase inhibitors from cultures of Biscogniauxia capnodes SWUF15-40 fungus.","authors":"Audomsak Churat, Praewpan Katrun, Chittima Laohpongspaisan, Wiyada Mongkolthanaruk, Chamaiporn Champasri, Pairot Moontragoon, Nuttika Suwannasai, Ek Sangvichien, Pakarapon Poonsukkho, Sirirath McCloskey","doi":"10.1007/s11418-025-01876-9","DOIUrl":"https://doi.org/10.1007/s11418-025-01876-9","url":null,"abstract":"The search for a potent α-glucosidase inhibitor from the fungus Biscogniauxia capnodes SWUF15-40 yielded eighteen compounds. A comprehensive analysis from NMR and MS data revealed three new α-pyrones, biscogniapyrones A-C (1-3), two new isocoumarins (5 and 6), and thirteen known compounds. The configurations were assigned from calculated 13C NMR chemical shifts and ECD spectra, together with 1H NMR analysis of Mosher esters. Several compounds exhibited effective inhibitory activity against α-glucosidase with IC50 values in the range of 0.041-0.257 mM, which are lower than the positive control, acarbose (IC50 0.713 mM). The proposed non-competitive mode of inhibition was deduced from Lineweaver-Burk plots together with Km and Vmax values. In silico dockings of the strongest inhibitor, compound 3 were studied. Three out of the five determined allosteric sites of the enzyme model were favorable, with closed free binding energies of roughly - 4.00 kcal/mol. The binding interactions observed between 3 and amino acids in the pocket sites were hydrogen bonding and hydrophobic interactions. These findings, therefore, provide opportunities for drug development processes to be carried out.","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0