靶向癌细胞化疗耐药因子的天然产物的研究与开发。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2025-08-08 DOI:10.1007/s11418-025-01942-2

Takahiro Matsumoto

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引用次数: 0

摘要

热休克蛋白（HSPs）在多种肿瘤中发挥重要作用；促进肿瘤耐药、细胞增殖和转移；并且被认为是抗癌药物治疗失败的主要原因。此外，癌症干细胞（CSCs）已在许多类型的恶性肿瘤中被发现，包括白血病、乳腺癌、结直肠癌和脑癌，由于其抗癌药物和放射治疗的耐药性，它是癌症治疗失败的主要原因。因此，包括我们小组在内的许多研究人员已经研究和开发了针对癌细胞化疗耐药因子的天然产物。本文综述了利用一种独特的检测系统发现的化疗耐药因子抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Investigation and development of natural products that target chemotherapy resistance factors in cancer cells

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Investigation and development of natural products that target chemotherapy resistance factors in cancer cells

Heat shock proteins (HSPs) play an important role in several tumors; contribute to anti-cancer drug resistance, cell proliferation, and metastasis; and have been suggested as a major cause of failed anti-cancer drug treatment. In addition, cancer stem cells (CSCs) have been identified in many types of malignancies, including leukemia, breast, colorectal, and brain cancers, and are a leading cause of failed cancer treatment owing to their anti-cancer drug and radiation therapy resistance. Therefore, many researchers, including our group, have investigated and developed natural products that target chemotherapy resistance factors in cancer cells. This review introduces the inhibitors of chemotherapy resistance factors discovered using a unique assay system.

Graphical Abstract

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.