Journal of Natural Medicines最新文献_第3页

SIRT5: a potential target for discovering bioactive natural products. SIRT5：发现生物活性天然产物的潜在靶标。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-20 DOI: 10.1007/s11418-024-01871-6

Yuwei Xie, Nali Cai, Xiaohua Liu, Liangliang He, Yiming Ma, Changyu Yan, Juan Liang, Shu-Hua Ouyang, Ao Luo, Yingzhi He, Jun Lu, Dang Ao, Jia Liu, Zhonglv Ye, Bin Liu, Rong-Rong He, Wen Li

{"title":"SIRT5: a potential target for discovering bioactive natural products.","authors":"Yuwei Xie, Nali Cai, Xiaohua Liu, Liangliang He, Yiming Ma, Changyu Yan, Juan Liang, Shu-Hua Ouyang, Ao Luo, Yingzhi He, Jun Lu, Dang Ao, Jia Liu, Zhonglv Ye, Bin Liu, Rong-Rong He, Wen Li","doi":"10.1007/s11418-024-01871-6","DOIUrl":"10.1007/s11418-024-01871-6","url":null,"abstract":"<p><p>Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mitochondrial matrix. SIRT5 plays a key role in metabolism and antioxidant responses, and is an important regulator for maintaining intracellular homeostasis. Given its involvement in multiple cellular processes, dysregulation of SIRT5 activity is associated with a variety of diseases. This review explores the structural characteristics of SIRT5 that influence its substrate specificity, highlights recent research advances, and summarizes its four key enzymatic activities along with their corresponding substrates in disease contexts. We also discuss the natural products that modulate SIRT5 activity and identify potential targets of SIRT5 through virtual docking, which may provide new therapeutic avenues. Although the mechanism of SIRT5 in diseases needs to be further elucidated and deglutathionylation activities are still at an early stage, targeting SIRT5 and its substrates holds significant promise for the development of novel therapeutics.</p>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway. 真菌蛋白D1通过激活p53/miR-34a信号通路抑制A549细胞的增殖。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-18 DOI: 10.1007/s11418-024-01869-0

Min-Hui Zhang, Fang Liu, Wen-Hui Gao, Zhao-Kun Liu

引用次数: 0

Meroterpenes and prenylated acylphloroglucinol from the aerial parts of Hypericum erectum. 直立连翘（Hypericum erectum）地上部的萜类和戊酰化酰基间苯三酚。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-18 DOI: 10.1007/s11418-025-01883-w

Rena Takizawa, Chiaki Nagata, Sang-Yong Kim, Daisuke Tsuji, Mareshige Kojoma, Reiko Akagi, Yoshiki Kashiwada, Naonobu Tanaka

引用次数: 0

Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds 四种新的糖苷酸甲酯和一种新的糖苷酸。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-13 DOI: 10.1007/s11418-025-01877-8

Masateru Ono, Renjyu Murakami, Shin Yasuda, Hiroyuki Miyashita, Hitoshi Yoshimitsu, Ryota Tsuchihashi, Masafumi Okawa, Junei Kinjo

{"title":"Four new acylated glycosidic acid methyl esters and a new glycosidic acid from Ipomoea lacunosa seeds","authors":"Masateru Ono, Renjyu Murakami, Shin Yasuda, Hiroyuki Miyashita, Hitoshi Yoshimitsu, Ryota Tsuchihashi, Masafumi Okawa, Junei Kinjo","doi":"10.1007/s11418-025-01877-8","DOIUrl":"10.1007/s11418-025-01877-8","url":null,"abstract":"<div><p>Resin glycosides, characteristic of plants of the Convolvulaceae family, are well-known purgative constituents found in traditional medicinal crude drugs, such as Rhizoma Jalapae, Rhizoma Jalapae Braziliensis, Orizaba Jalapa Tuber, and Pharbitidis Semen. The isolated compounds exhibited a wide range of biological activities, including antibacterial, ionophoric, anti-inflammatory, antiviral, and multidrug-resistance-modulating properties, as well as cytotoxicity against cancer cells. <i>Ipomoea lacunosa</i> L. (Convolvulaceae) is an herbaceous vine native to the United States. Four new acylated glycosidic acid methyl esters (<b>1</b>–<b>4</b>) and one new glycosidic acid (<b>5</b>) were isolated from the methanol extract of the plant seed. The structures of <b>1</b>–<b>5</b> were elucidated using spectroscopic data in conjunction with our previous studies on the components of the crude resin glycoside fraction from <i>I. lacunosa</i> seeds. Compounds <b>1</b> and <b>2</b> were identified as heptaglycosides, <b>3</b> as an octaglycoside, and <b>4</b> as a nonaglycoside, all sharing methyl 3<i>S</i>,11<i>S</i>-dihydroxytetradecanoate as a common aglycone. The saccharide moieties were partially acylated by glycosidic acid, 7<i>S</i>-hydroxydecanoic acid 7-<i>O</i>-<i>β</i>-<span>d</span>-quinovopyranoside, and organic acids, including (<i>E</i>)-2-methylbut-2-enoic, 2<i>S</i>-methylbutyric, and 2<i>R</i>-methyl-3<i>R</i>-hydroxybutyric acids. Compound <b>5</b> was identified as a triglycoside with a new aglycone, 4,11-dihydroxyhexadecanoic acid, which is the first glycosidic acid with a hydroxyl group at C-4 of the aglycone moiety.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"79 2","pages":"422 - 434"},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11418-025-01877-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases 铁(II)/α kg依赖性加氧酶生物合成独特天然产物支架。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-06 DOI: 10.1007/s11418-025-01880-z

Takayoshi Awakawa

{"title":"Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases","authors":"Takayoshi Awakawa","doi":"10.1007/s11418-025-01880-z","DOIUrl":"10.1007/s11418-025-01880-z","url":null,"abstract":"<div><p>Fe(II)/αKG-dependent oxygenases are multifunctional oxidases responsible for the formation of unique natural product skeletons. Studies of these enzymes are important because the knowledge of their catalytic functions, enzyme structures, and reaction mechanisms can be used to create non-natural enzymes through mutation and synthesize non-natural compounds. In this review, I will introduce the research we have conducted on two fungal Fe(II)/αKG-dependent oxygenases, TlxI-J and TqaL. TlxI-J is the first Fe(II)/αKG-dependent oxygenase type enzyme heterodimer that catalyzes consecutive oxidation reactions, hydroxylation followed by retro-aldol or ketal formation, to form the complex skeletons of meroterpenoids. TqaL is the first naturally occurring aziridine synthase, and I will discuss the mechanism of its unique C–N bond formation in nonproteinogenic amino acid biosynthesis. This review will advance research on the discovery of new enzymes and the analysis of their functions by reviewing the structures and functions of these extraordinary Fe(II)/αKG-dependent oxygenases, and promote their use in the synthesis of new natural medicines.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"79 2","pages":"303 - 313"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11418-025-01880-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC50: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation 以(+)-真烯氧化物为基础合成了有效的sars - cov - 23c样蛋白酶抑制剂(+)-真烯氧化物-3,6-二酮（IC50: 0.048 μM）；内生发酵法研究(+)-真戊二酸类似物中铅。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-02-03 DOI: 10.1007/s11418-024-01874-3

Shoji Maehara, Moeka Kumamoto, Shogo Nakajima, Yuhzo Hieda, Koichi Watashi, Toshiyuki Hata

{"title":"Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC50: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation","authors":"Shoji Maehara, Moeka Kumamoto, Shogo Nakajima, Yuhzo Hieda, Koichi Watashi, Toshiyuki Hata","doi":"10.1007/s11418-024-01874-3","DOIUrl":"10.1007/s11418-024-01874-3","url":null,"abstract":"<div><p>Since the coronavirus disease 2019 (COVID-19) outbreak, research has been conducted on treatment and countermeasures against the causative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the development of new seeds is urgently needed because viruses have the characteristic of becoming resistant through mutation. We hypothesize that endophytes produce antiviral substances to combat foreign viruses in host plants. According to this hypothesis, the seeds of therapeutic agents for infectious diseases could be obtained from endophytes by culture experiments. This report found that <i>Aspergillus</i> sp. endophyte isolated from <i>Catharanthus roseus</i> produced ( +)-eupenoxide and its 3-ketone form with anti-SARS-CoV-2 activity. In addition, ( +)-eupenoxide-3,6-diketon was discovered as a new compound with potent 3C-like protease inhibitory activity (IC<sub>50</sub>: 0.048 μM) by synthesis based on ( +)-eupenoxide. This finding could be an important evidence that endophytic fungi symbiosis with medicinal plants is useful as antiviral producers.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"79 2","pages":"357 - 370"},"PeriodicalIF":2.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new diterpenoid, carneadiol, isolated from Nocardia carnea IFM 12324 从卡尼诺卡菌IFM 12324中分离得到一个新的二萜类化合物卡尼二醇。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-01-28 DOI: 10.1007/s11418-025-01878-7

Yasumasa Hara, Ayaka Nakamura, Teruhisa Manome, Akiko Takaya, Hiroki Takahashi, Sayaka Ban, Takashi Yaguchi, Masami Ishibashi

引用次数: 0

New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities 曼氏蛇蛾气部新脑苷类及神经酰胺类成分的研究。F.及其细胞毒活性。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-01-19 DOI: 10.1007/s11418-024-01875-2

Yves M. Mba Nguekeu, Herman D. Sonfack Fozeng, Chika Ifeanyi Chukwuma, Saw Y. Yu Hnin, Nhat Nam Hoang, Emmanuel Mfotie Njoya, Silvère Augustin Ngouela, Mathieu Tene, Tshepiso Jan Makhafola, Hiroyuki Morita, Maurice Ducret Awouafack

{"title":"New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities","authors":"Yves M. Mba Nguekeu, Herman D. Sonfack Fozeng, Chika Ifeanyi Chukwuma, Saw Y. Yu Hnin, Nhat Nam Hoang, Emmanuel Mfotie Njoya, Silvère Augustin Ngouela, Mathieu Tene, Tshepiso Jan Makhafola, Hiroyuki Morita, Maurice Ducret Awouafack","doi":"10.1007/s11418-024-01875-2","DOIUrl":"10.1007/s11418-024-01875-2","url":null,"abstract":"<div><p>Two new cerebrosides, raphimanosides A (<b>1</b>) and B (<b>2</b>), and a new ceramide, raphimanide (<b>3</b>), were isolated from the aerial parts of <i>Raphidiocystis mannii</i> Hook. f., along with ten known compounds (<b>4–13</b>). Their structures were fully established, based on extensive analyses of <sup>1</sup>H, <sup>13</sup>C, DEPT, 2D NMR, ESIMS, and HRESIMS data and chemical conversion. Subsequently, methanol extract, ethyl acetate, and <i>n</i>-butanol soluble portions and the isolated compounds <b>1–9</b>, <b>12</b>, and <b>13</b> were assayed for their cytotoxic effects against three human cancer cell lines (MCF-7, HeLa and A549). None of the new compounds demonstrated efficacy against the tested cell lines. In contrast, the methanol extract, ethyl acetate soluble portion, and compounds <b>6</b>, <b>7</b>,<b> 9</b>, <b>12</b>, and <b>13</b> showed moderate to low activities against different tested cell lines. Ethyl acetate soluble portion and compounds <b>13</b> and <b>7</b> were the most potent samples with the IC<sub>50</sub> value of 41.25 μg/mL, 36.76 μM, and 13.16 μM against MCF-7, HeLa, and A549 cell lines, respectively. To the best of our knowledge, this is the inaugural investigation into the chemical constituents of the genus <i>Raphidiocystis</i>, offering novel insights into the chemotaxonomy of this hitherto poorly understood genus.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"79 2","pages":"412 - 421"},"PeriodicalIF":2.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ergostane-type steroids from mushrooms of Pleurotus genus 从侧耳菇属蘑菇中提取麦角甾类类固醇。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-01-17 DOI: 10.1007/s11418-024-01872-5

Takashi Kikuchi

引用次数: 0

Resveratrol as a BCL6 natural inhibitor suppresses germinal center derived Non-Hodgkin lymphoma cells growth 白藜芦醇作为BCL6天然抑制剂抑制生发中心来源的非霍奇金淋巴瘤细胞生长。

IF 2.5 4区医学

Journal of Natural Medicines Pub Date : 2025-01-15 DOI: 10.1007/s11418-024-01873-4

Yajing Xing, Chunbin Tan, Zhoujiang Liu, Yanqi Liu, Simei Liu, Guixue Wang, Yadong Zhong

{"title":"Resveratrol as a BCL6 natural inhibitor suppresses germinal center derived Non-Hodgkin lymphoma cells growth","authors":"Yajing Xing, Chunbin Tan, Zhoujiang Liu, Yanqi Liu, Simei Liu, Guixue Wang, Yadong Zhong","doi":"10.1007/s11418-024-01873-4","DOIUrl":"10.1007/s11418-024-01873-4","url":null,"abstract":"<div><p>Non-Hodgkin lymphomas (NHL), including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), and follicular lymphoma (FL), predominantly arise from B cells undergoing germinal center (GC) reactions. The transcriptional repressor B-cell lymphoma 6 (BCL6) is indispensable for GC formation and contributes to lymphomagenesis via its BTB domain-mediated suppression of target genes. Dysregulation of BCL6 underpins the pathogenesis of GC-derived NHL. While pharmacological targeting the BCL6-BTB domain has shown therapeutic promise, natural product-based inhibitors remain underexplored. In this study, resveratrol, a polyphenolic compound derived from grapes, was identified as a potent BCL6 inhibitor through a comprehensive screen of traditional Chinese medicine monomers using Homogeneous Time-Resolved Fluorescence (HTRF) assay. As a BCL6 natural inhibitor, resveratrol effectively disrupted the BCL6/SMRT interaction, reactivated suppressed gene expression, and inhibited the proliferation of GC-derived NHL cells. It also exhibited synergistic efficacy when combined with EZH2 and PRMT5 inhibitors. In vivo, resveratrol suppressed GC formation, reduced follicular helper T-cell frequencies, impaired class-switch recombination, and disrupted immunoglobulin affinity maturation. Furthermore, it markedly inhibited the progression of GC-derived NHL in animal models. Our findings demonstrate that resveratrol functions as a natural BCL6 inhibitor with significant therapeutic potential for the treatment of GC-derived NHL.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":"79 2","pages":"399 - 411"},"PeriodicalIF":2.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11418-024-01873-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0