传统医学与现代科学：Halofuginone在对抗自身免疫性疾病中的作用。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2025-06-30 DOI:10.1007/s11418-025-01927-1

Juan Zhu, Shiyao Liu, Peipei Liu, Kefeng Zhai, Hao Liu

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引用次数: 0

摘要

二氯氰胺。这是一种传统的中草药，历史上用于治疗疟疾，它含有活性化合物白藜芦醇。通过结构修饰，半合成了Halofuginone，保留了抗疟活性，降低了毒性。近年来的研究表明，Halofuginone具有广泛的生物活性，包括在自身免疫性疾病中的显著治疗潜力。通过调节异常免疫反应，抑制炎症，发挥抗纤维化作用，Halofuginone缓解症状，防止组织损伤在这些条件下。本文综述了Halofuginone在自身免疫性疾病中的研究进展，并讨论了该领域面临的主要挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases

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Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases

Dichroa febrifuga Lour., a traditional Chinese medicinal herb historically used for malaria treatment, contains the active compound Febrifugine. Through structural modification, Halofuginone was semi-synthesized, retaining antimalarial activity with reduced toxicity. Recent studies reveal Halofuginone’s broad biologic activities, including significant therapeutic potential in autoimmune diseases. By modulating abnormal immune responses, suppressing inflammation, and exerting antifibrotic effects, Halofuginone alleviates symptoms and prevents tissue damage in these conditions. This review comprehensively summarizes advances in Halofuginone research for autoimmune diseases and discusses key challenges in this field.

Graphical abstract

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.