CA: A Cancer Journal for Clinicians最新文献

Acute myeloid leukemia management and research in 2025

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-12-10 DOI: 10.3322/caac.21873

Hagop M. Kantarjian, Courtney D. DiNardo, Tapan M. Kadia, Naval G. Daver, Jessica K. Altman, Eytan M. Stein, Elias Jabbour, Charles A. Schiffer, Amy Lang, Farhad Ravandi

{"title":"Acute myeloid leukemia management and research in 2025","authors":"Hagop M. Kantarjian, Courtney D. DiNardo, Tapan M. Kadia, Naval G. Daver, Jessica K. Altman, Eytan M. Stein, Elias Jabbour, Charles A. Schiffer, Amy Lang, Farhad Ravandi","doi":"10.3322/caac.21873","DOIUrl":"https://doi.org/10.3322/caac.21873","url":null,"abstract":"The first 5 decades of research in acute myeloid leukemia (AML) were dominated by the cytarabine plus anthracyclines backbone, with advances in strategies including allogeneic hematopoietic stem cell transplantation, high-dose cytarabine, supportive care measures, and targeted therapies for the subset of patients with acute promyelocytic leukemia. Since 2017, a turning point in AML research, 12 agents have received regulatory approval for AML in the United States: venetoclax (BCL2 inhibitor); gemtuzumab ozogamicin (CD33 antibody–drug conjugate); midostaurin, gilteritinib, and quizartinib (fms-like tyrosine kinase 3 inhibitors); ivosidenib, olutasidenib, and enasidenib (isocitrate dehydrogenase 1 and 2 inhibitors); oral azacitidine (a partially absorbable formulation); CPX351 (liposomal encapsulation of cytarabine:daunorubicin at a molar ratio of 5:1); glasdegib (hedgehog inhibitor); and recently revumenib (menin inhibitor; approved November 2024). Oral decitabine-cedazuridine, which is approved as a bioequivalent alternative to parenteral hypomethylating agents in myelodysplastic syndrome, can be used for the same purpose in AML. Menin inhibitors, CD123 antibody–drug conjugates, and other antibodies targeting CD123, CD33, and other surface markers are showing promising results. Herein, the authors review the frontline and later line therapies in AML and discuss important research directions.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"5 4 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer care for transgender and gender-diverse people: Practical, literature-driven recommendations from the Multinational Association of Supportive Care in Cancer

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-12-09 DOI: 10.3322/caac.21872

Elizabeth J. Cathcart-Rake, Alexandre Chan, Alvaro Menendez, Denise Markstrom, Carla Schnitzlein, Yee Won Chong, Don S. Dizon

{"title":"Cancer care for transgender and gender-diverse people: Practical, literature-driven recommendations from the Multinational Association of Supportive Care in Cancer","authors":"Elizabeth J. Cathcart-Rake, Alexandre Chan, Alvaro Menendez, Denise Markstrom, Carla Schnitzlein, Yee Won Chong, Don S. Dizon","doi":"10.3322/caac.21872","DOIUrl":"https://doi.org/10.3322/caac.21872","url":null,"abstract":"In the United States, over 2 million individuals openly identify with a gender that differs from their sex assigned at birth. A cancer diagnosis is physically and psychologically taxing—and, in some, traumatic. However, for transgender and gender-diverse (TGD) people, many of whom have experienced discrimination in myriad health care settings, the challenges may be even greater. These recommendations focus on how best to deliver quality cancer care to transgender men (individuals who identify as men but were assigned female sex at birth), transgender women (individuals who identify as women but were assigned male sex at birth), and people who identify somewhere beyond this gender spectrum as nonbinary or using other terms, based on the available, albeit sparse, literature. This review broaches: (1) the epidemiology of cancer in TGD individuals, including the incidence of cancer and cancer-related mortality; (2) cancer center practices that are welcoming and affirming to TGD patients; (3) the need for awareness and intentionality in the spaces of diagnosis and treatment for cancer; (4) the inevitable conclusion that gender differences exist but much more needs to be learned about the impact of gender-affirming therapy, consisting of gender-affirming surgeries and gender-affirming hormone therapy, on cancer therapy; and (5) the efficacy and perceived safety of antineoplastic therapy and gender-affirming hormone therapy.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"2 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Swollen vs. Compounded Cross-linked High-Cis-1,4-Polybutadiene/n-Tetracosane Shape Memory Polymers 膨胀型与复合型交联高顺式-1,4-聚丁二烯/正十四烷形状记忆聚合物的比较

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-11-14 DOI: 10.1002/pol.20240820

Sayan Basak, Kevin A. Cavicchi

{"title":"Comparison of Swollen vs. Compounded Cross-linked High-Cis-1,4-Polybutadiene/n-Tetracosane Shape Memory Polymers","authors":"Sayan Basak, Kevin A. Cavicchi","doi":"10.1002/pol.20240820","DOIUrl":"https://doi.org/10.1002/pol.20240820","url":null,"abstract":"Blending elastomers with phase change materials offers a modular approach to fabricating smart materials, such as shape memory polymers. This study compares shape memory polymers prepared by peroxide cross-linking a blend of polybutadiene and n-tetracosane (compounded samples) versus swelling peroxide cross-linked polybutadiene in n-tetracosane (swollen samples). Characterization of the thermal, thermomechanical, and shape memory behavior of the two types of samples show very similar behavior as a function of polybutadiene content. The sample with ca. 30% polybutadiene displayed shape memory metrics of ~90% fixity and ~99% recovery at 25% applied strain. The main difference in the samples was the change in fixity and recovery with cycling where they were heated and cooled using water baths. The compounded samples exhibited a 1.4% decrease in fixity, 0.2% decrease in recovery, and 2.25% weight loss over 20 cycles. In contrast, the swollen samples have a 4.2% decrease in fixity, 0.4% decrease in recovery, and 5.63% weight loss over 20 cycles. This weight loss was attributed to the expulsion of the n-tetracosane that experienced a higher driving force in the swollen sample with stretched chains. The cyclic and long-term aging of these polymers is different depending on the preparation method to incorporate the n-tetracosane into the material.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"24 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introducing Antifouling Properties Onto Janus-Like Decellularized Corneas via Graft-From Zwitterionic Polymers 通过接枝自聚维塔利聚合物在类人角膜脱细胞中引入防污特性

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-11-14 DOI: 10.1002/pol.20240720

Simin Wu, Jiandong Han, Xiukai Guo, Zilong Rao, Kexin Zhang, Daping Quan, Ying Bai

{"title":"Introducing Antifouling Properties Onto Janus-Like Decellularized Corneas via Graft-From Zwitterionic Polymers","authors":"Simin Wu, Jiandong Han, Xiukai Guo, Zilong Rao, Kexin Zhang, Daping Quan, Ying Bai","doi":"10.1002/pol.20240720","DOIUrl":"https://doi.org/10.1002/pol.20240720","url":null,"abstract":"The lack of endothelial layer hinders the use of decellularized corneal stroma in keratoplasty, resulting in adverse effects, such as non-specific protein adsorption and corneal oedema after implantation, which leads to rapid failure of the ophthalmic implants. In this study, superhydrophilic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) was gently introduced to the porcine-derived decellularized corneal stroma matrix (pDCSM), aiming to resist undesirable biofilm adsorption within the ocular environment. After complete decellularization, the pDCSM was first methacrylated by the integration of methacrylic anhydride. Consecutively, PMPC was only grafted from the back surface (endothelium side) of the methacrylated pDCSM through surface-initiated free radical polymerization. This one-side surface-modified pDCSM not only retained good optical transmittance and mechanical properties that were comparable to the untreated pDCSM, but both surfaces of the same artificial cornea also showed non-cytotoxicity and good biocompatibility. Moreover, the PMPC-grafted back surface exhibited considerable antifouling properties that resisted both protein and cell adhesion. Consequently, such Janus-like artificial cornea holds great promise in future ophthalmic applications, which may serve as a springboard for the design of versatile decellularized extracellular matrix based biomedical implants with Janus-like properties.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"32 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Characterization of Low-Voltage Responsive Nanocomposite Shape-Changing Hydrogels/Carbon Nanofibers With Enhanced Mechanical Properties 具有增强机械性能的低电压响应型纳米复合材料--可改变形状的水凝胶/碳纳米纤维的制备与表征

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-11-14 DOI: 10.1002/pol.20240746

Jiale Li, Qiang Ma, Guohe Xu, Chunqiang Jiang, Mengru Wang

{"title":"Preparation and Characterization of Low-Voltage Responsive Nanocomposite Shape-Changing Hydrogels/Carbon Nanofibers With Enhanced Mechanical Properties","authors":"Jiale Li, Qiang Ma, Guohe Xu, Chunqiang Jiang, Mengru Wang","doi":"10.1002/pol.20240746","DOIUrl":"https://doi.org/10.1002/pol.20240746","url":null,"abstract":"High-voltage responsiveness and poor mechanical properties hindered the practical applications of electro-induced shape-changing hydrogels (EISCHs). In previous work, mechanical properties were improved simply by increasing the degree of crosslinking, which resulted in reduced deformation capacity. Therefore, the nanocomposite technique of reinforcing nondeformable hydrogels' mechanical properties was introduced into EISCHs, resulting in the successful synthesis of Poly (N-isopropylacrylamide-co-5-acrylamido-1,10-phenanthroline bis (1,10-phenanthroline) iron (II))/hydrophilic-treated hydroxylated carbon nanofibers (P(NIPAM-Fe(phen)3)/HMWCNFs) nanocomposite shape-changing hydrogel that exhibits outstanding mechanical properties, doesn't have its deformation ability weakened and possesses low-voltage responsiveness in this work. The impact of various hydrophilic-treated hydroxylated carbon nanofibers (HMWCNFs) content on hydrogels' structure, swelling, crosslinking, mechanics and electro-induced shape-changing properties was investigated. As the HMWCNFs content increased (0.2%–1.0%), the tensile and compressive strengths increased, marking 6.67 times and 2.91 times rise over hydrogel without HMWCNFs. The deformation ability of P(NIPAM-Fe(phen)3/HMWCNFs) hydrogel was higher than without HMWCNFs at minimum response voltage 10 V. The physical entanglements and hydrogen bonding between HMWCNFs and polymer chains reduced adhesion energy and provided energy dissipation. HMWCNFs, as a conductive filler, facilitated electron transfer. The hydrogel swelled and shrank due to the transition between 5-acrylamido-1,10-phenanthroline bis (1,10-phenanthroline) iron (II) (Fe(phen)3) network iron (II) and iron (III) states under low-voltage stimulation.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"7 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Hydroxyl Modified Hollow Glass Microsphere Composite Isocyanate-Based Polyimide Foam and Optimization Strategy Based on Different Bonding Mechanisms 羟基改性中空玻璃微球复合异氰酸酯基聚酰亚胺泡沫的制备及基于不同粘合机制的优化策略

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-11-13 DOI: 10.1002/pol.20240796

Yifei Jin, Gaohui Sun, Guocheng Zhou, Rongrong Chen, Jun Wang, Zailin Yang, Shihui Han

{"title":"Fabrication of Hydroxyl Modified Hollow Glass Microsphere Composite Isocyanate-Based Polyimide Foam and Optimization Strategy Based on Different Bonding Mechanisms","authors":"Yifei Jin, Gaohui Sun, Guocheng Zhou, Rongrong Chen, Jun Wang, Zailin Yang, Shihui Han","doi":"10.1002/pol.20240796","DOIUrl":"https://doi.org/10.1002/pol.20240796","url":null,"abstract":"In this study, the hydroxyl modified hollow glass microsphere (HM-HGM) is added to different foaming slurries of isocyanate-based polyimide foam (IBPIF) at varying ratios, and different bonding effects are formed to optimize the dispersion behavior. Then, the novel HGM composited IBPIF (IBPIF/HGM) is prepared. Hydroxyl groups on HM-HGM establish hydrogen bonding effect with pyromellitic acid dimethyl ester and dimethyl formamide in the white slurry and react with isocyanate groups in the black slurry. The cell structure of IBPIF is altered to improve its sound absorption performance and mechanical behaviors. Compared with IBPIF/HGM-0, the average cell size of IBPIF/HGM-1 and BPIF/HGM-5 decreases significantly. The sound absorption performance and mechanical behaviors of them are improved to some extent. Compared with samples in which the HM-HGM is added alone to a single slurry, when the dosage ratio of HM-HGM in black and white slurries is 1:1, IBPIF/HGM-3 has more uniform cell structure. The change of IBPIF cell structure by the introduction of HM-HGM and the unique structure of HM-HGM can enhance the sound absorption performance and mechanical behaviors of IBPIF. The design idea of different bonding mechanisms significantly provides technical assistance to enhance the acoustic performance of polymeric foam materials.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"38 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Ferrocene-Containing Schiff Bases Based on 3-Aminopropyltriethoxysilane Oligomers for Covalent Modification of Glass Surfaces and Creation of Soft Magnetic Materials 基于 3-氨基丙基三乙氧基硅烷低聚物的含二茂铁席夫碱的合成，用于共价改性玻璃表面和创建软磁材料

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-11-13 DOI: 10.1002/pol.20240629

Raisa Dvorikova, Galy Markova, Anton Shulgin, Ludmila Komarova, Oleg Baranov, Igor Shchetinin, Dmitry Bagrov, Mikhail Buzin, Zinaida Klemenkova, Yaroslav Mezhuev

{"title":"Synthesis of Ferrocene-Containing Schiff Bases Based on 3-Aminopropyltriethoxysilane Oligomers for Covalent Modification of Glass Surfaces and Creation of Soft Magnetic Materials","authors":"Raisa Dvorikova, Galy Markova, Anton Shulgin, Ludmila Komarova, Oleg Baranov, Igor Shchetinin, Dmitry Bagrov, Mikhail Buzin, Zinaida Klemenkova, Yaroslav Mezhuev","doi":"10.1002/pol.20240629","DOIUrl":"https://doi.org/10.1002/pol.20240629","url":null,"abstract":"A ferrocene-containing oligoorganosiloxane with a number-average degree of polymerization of 8.8 and a number-average molecular weight of 3200 is synthesized by hydrolytic condensation of 3-aminopropyltriethoxysilane followed by chemical modification of the resulting oligomer with acetylferrocene. Its structure is characterized by MALDI-TOF, NMR and IR spectroscopy. 1H NMR spectroscopy shows the predominance of more thermodynamically stable units containing anti-configuration Schiff bases. Using IR spectroscopy as well as experimental determination of surface energy and its polar (acid–base) and dispersion components, the covalent immobilization of ferrocene-containing oligoorganosiloxane on a glass surface after heating at 110°C is shown. The formed coating provides hydrophobization, acid–base indifference of the glass surface and serves as a precursor for the formation of magnetically soft materials after pyrolysis in argon already at 350°C. The main stages of ferrocene-containing oligoorganosiloxane thermal destruction in an inert atmosphere and the formation of a mixture of iron and silicon oxides during its thermal oxidative destruction are established by combination of TGA/DTA, IR spectroscopy and elemental analysis. The proposed approach opens up new possibilities for functionalizing silicates surfaces, creating magnetic glasses, as well as regulating surface energy and its components.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"75 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Glass Transition Temperature in Thermo-Responsive Epoxy Shape Memory Polymers: The Roles of Chemical Crosslinking Density and Chain Flexibility 热响应环氧形状记忆聚合物玻璃化温度的调节：化学交联密度和链柔性的作用

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-11-11 DOI: 10.1002/pol.20240728

Yijia Guan, Hui Guo, Xiaofeng Jia, Jieyi Qin, Yue Yang, Kun Cao, Tao Li, Jianguo Liao, Yanru Zhang

{"title":"Regulation of Glass Transition Temperature in Thermo-Responsive Epoxy Shape Memory Polymers: The Roles of Chemical Crosslinking Density and Chain Flexibility","authors":"Yijia Guan, Hui Guo, Xiaofeng Jia, Jieyi Qin, Yue Yang, Kun Cao, Tao Li, Jianguo Liao, Yanru Zhang","doi":"10.1002/pol.20240728","DOIUrl":"https://doi.org/10.1002/pol.20240728","url":null,"abstract":"Shape memory polymers (SMPs) are novel kinds of smart materials whose shape can be changed in external conditions such as heat stimulus. Due to their excellent structural versatility and high elastic strain, they have important applications in the field of biomaterials. Here, a series of amorphous shape memory polymer materials are prepared and their shape memory properties and glass transition temperature (Tg) are also investigated. A special kind of epoxy polymer, whose shape can be changed at around physiological temperature, is synthesized by regulating the crosslinking density and introducing flexible aliphatic epoxy chains. The shape memory function of this epoxy polymer is studied by deformation test. In addition, to explore their application in the field of biomedical materials, the biocompatibility of the materials are evaluated, including the effects on the erythrocyte hemolysis rate and cell activity. The experimental results show that this kind of epoxy polymer has good shape memory function and biocompatibility.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"108 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized Thermoresponsive Behavior in P(NIPAm-co-AAc) Copolymers: Structural Insights From Rheology and Small Angle X-Ray Scattering P(NIPAm-co-AAc)共聚物的局部热致伸缩行为：流变学和小角 X 射线散射的结构启示

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-11-10 DOI: 10.1002/pol.20240799

S. P. Fernandez Bordín, E. Rufeil Fiori, J. M. Padró, V.M. Galván Josa, T. S. Plivelic, M. R. Romero

{"title":"Localized Thermoresponsive Behavior in P(NIPAm-co-AAc) Copolymers: Structural Insights From Rheology and Small Angle X-Ray Scattering","authors":"S. P. Fernandez Bordín, E. Rufeil Fiori, J. M. Padró, V.M. Galván Josa, T. S. Plivelic, M. R. Romero","doi":"10.1002/pol.20240799","DOIUrl":"https://doi.org/10.1002/pol.20240799","url":null,"abstract":"Stimuli-responsive polymers stand out for their ability to respond to small environmental changes. One of the most representative thermo-sensitive materials is poly(N-isopropyl acrylamide) (PNIPAm), which presents reversible phase transitions close to the human body temperature. However, previous studies observed that the copolymerization of NIPAm with small quantities of different monomers like acrylic acid (AAc) results in copolymers with reduced or lost thermo-responsivity. In this study, thermo-sensitive PNIPAm, pH-sensitive poly(acrylic acid) (PAAc), and various proportions of their copolymers P(NIPAm-co-AAc) were obtained by free radical polymerization and thoroughly characterized. Rheological and structural studies reveal the remaining thermosensitivity of the copolymers manifested at short molecular ranges. These alterations in short-range interactions are observed in all samples containing NIPAm, and they are evidenced by changes in the fractality of their structure and flow index behavior of the Viscosity Ostwald–de Waele Model. Particularly, when the copolymer proportion of NIPAm/AAc is about 40/60, the Beaucage model reveals two structural levels, ~200 and ~10 nm. Furthermore, the model exhibits a thermal response of the lower-size substructures, indicating possible segregation of NIPAm-rich regions from copolymer chains. The evidence found in this work could contribute to the development of nanosystems, in which local thermoresponsive effects are sought, such as for active drug targeting.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"20 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Lipid–Polymer Conjugates by Photoiniferter Polymerization and Application to Cell Surface Modification 通过光iferter 聚合法制备脂质聚合物共轭物并将其应用于细胞表面修饰

IF 254.7 1区医学

CA: A Cancer Journal for Clinicians Pub Date : 2024-11-10 DOI: 10.1002/pol.20240850

Wenjin Wang, Shengjie Liu, Yijia Yu, Wenjuan Xia, Zhaoqiang Wu, Hong Chen

{"title":"Preparation of Lipid–Polymer Conjugates by Photoiniferter Polymerization and Application to Cell Surface Modification","authors":"Wenjin Wang, Shengjie Liu, Yijia Yu, Wenjuan Xia, Zhaoqiang Wu, Hong Chen","doi":"10.1002/pol.20240850","DOIUrl":"https://doi.org/10.1002/pol.20240850","url":null,"abstract":"The growing demand for lipid–polymer conjugates (LPCs) in biomedicine highlights the need for efficient synthesis methods. This study presents a novel Y-type photoiniferter reagent (Lipid-PIT) with a diethyldithiocarbamate group and a diacylglycerol group. Lipid-PIT efficiently initiated the polymerization of vinyl monomers such as oligo(ethylene glycol) methacrylate (OEGMA), N,N-dimethylacrylamide (DMA), tert-butyl acrylate (tBA), and n-butyl acrylate (nBA) under UV irradiation at room temperature, yielding LPCs. Proton NMR confirmed the presence of diethyldithiocarbamate and diacylglycerol moieties at the chain ends. The polymerization kinetics of DMA showed a linear increase in molecular weight (Mn) with time, with a polydispersity (Đ) below 1.50, demonstrating high controllability. Moreover, Lipid-PIT allows for the creation of block copolymers via secondary chain extension. In vitro assays revealed that LPCs synthesized from OEGMA monomers successfully modified L929 and HeLa cell surfaces and exhibited good biocompatibility. This study offers a rapid, efficient method for LPC synthesis with promising biomedical applications.","PeriodicalId":137,"journal":{"name":"CA: A Cancer Journal for Clinicians","volume":"17 1","pages":""},"PeriodicalIF":254.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0