Acta Otorhinolaryngologica Italica最新文献

{"title":"Cochlear implant procedure. Italian Clinical Practice Guidelines of the Italian Society of Otorhinolaryngology (SIOeChCF) and Italian Society of Audiology and Phoniatrics (SIAF). Part 1: cochlear implants in adults.","authors":"Stefano Berrettini, Domenico Cuda, Silvia Minozzi, Franca Artioli, Umberto Barbieri, Cristian Borghi, Eliana Cristofari, Giorgio Conte, Davide Cornolti, Diego di Lisi, Anna Rita Fetoni, Simona Fiori, Elisabetta Genovese, Giorgia Girotto, Marinella Majorano, Pasquale Marsella, Emanuele Marzetti, Maria Nicastri, Gaetano Paludetti, Nicola Quaranta, Patrizia Trevisi, Diego Zanetti, Michela Cinquini, Francesca Forli, Sara Ghiselli","doi":"10.14639/0392-100X-N3081","DOIUrl":"10.14639/0392-100X-N3081","url":null,"abstract":"<p><strong>Objective: </strong>Cochlear implant (CI) is a well-established treatment for adults with sensorineural hearing loss and without benefit from hearing aids. The Italian guidelines date back 15 years; given the expansion of indications for CI, including single side deafness and asymmetrical hearing loss, it became necessary to establish updated guidelines.</p><p><strong>Methods: </strong>Thirteen experts and 2 patient representatives selected the key questions and drew up recommendations. The document was developed following GRADE methodology. The methodological team of the Mario Negri Pharmacological Research Institute performed systematic reviews for each question and supported the overall process.</p><p><strong>Results: </strong>Five key questions were identified and recommendations formulated, with subgroups and considerations on implementation.</p><p><strong>Conclusions: </strong>Though the systematic research of scientific literature found a scarcity of randomised trials and an overall poor conduct and reporting quality of primary studies and systematic reviews, strong or conditional recommendations in favour of CI have been formulated for different subgroups of patients. Further studies should enrol a larger number of participants and use consistent instruments to evaluate hearing outcomes, in order to increase the comparability of results and data pooling with meta-analysis.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"45 1","pages":"47-57"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of changes in pre- and postoperative inflammatory blood markers in HPV-negative head and neck squamous cell carcinomas.","authors":"Tommaso Mazzocco, Andrea Migliorelli, Giancarlo Tirelli, Michele Tomasoni, Vittorio Rampinelli, Cesare Piazza, Marco Ferrari, Piero Nicolai, Vittorio Baggio, Valentina Lupato, Francesco Uderzo, Franco Trabalzini, Simone Mauramati, Andrea Ciorba, Fabiola Giudici, Jerry Polesel, Daniele Borsetto, Paolo Boscolo-Rizzo","doi":"10.14639/0392-100X-N2955","DOIUrl":"10.14639/0392-100X-N2955","url":null,"abstract":"<p><strong>Objective: </strong>Neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are inflammatory markers easily obtained from a routine complete blood count, and their preoperative values have recently been correlated with oncological outcomes in patients with HPV-negative head and neck squamous cell carcinoma (HNSCC). The aim of this study is to evaluate the prognostic value of NLR and LMR before and after treatment in patients with HPV-negative HNSCC undergoing up-front surgical treatment.</p><p><strong>Methods: </strong>This multicentric retrospective study was performed on a consecutive cohort of patients treated by upfront surgery for HPV-negative HNSCC between April 2004 and June 2018. Only patients whose pre- and postoperative NLR and LMR were available were included. Their association with local, regional and distant failure, progression-free survival (PFS) and overall survival (OS) was calculated.</p><p><strong>Results: </strong>A total of 493 patients (mean age 68 years) were enrolled. The mean follow-up time was 54 months. Pre-surgical NLR ≥ 3.76 was associated with a high risk of regional failure (HR = 2.21, 95% CI: 1.08-5.55), disease progression (HR = 1.55, 95% CI: 1.07-2.25) and death (HR = 1.40, 95% CI: 0.94-2.10). A post-surgical LMR < 2.92 had a significant impact on disease progression (HR = 1.92, 95% CI: 1.13-3.28) and OS (HR = 2.98, 95% CI: 1.53-5.81). Patients with stable NLR ≥ 3.76 in the pre- and postoperative period had worse OS and PFS.</p><p><strong>Conclusions: </strong>Our results support that pre- and postoperative NLR and LMR can be useful in identifying patients at risk of local, regional, or distant recurrence who may require closer follow-up or more aggressive treatment.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"45 1","pages":"10-20"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bama pig is a suitable animal for studying laryngopharyngeal reflux disease.","authors":"Qingyang Shi, Yuguang Wang, Lihong Zhang, Haiyan An","doi":"10.14639/0392-100X-N2734","DOIUrl":"10.14639/0392-100X-N2734","url":null,"abstract":"<p><strong>Objective: </strong>To assess the suitability of Bama pigs as a model for laryngopharyngeal reflux disease (LPRD) research.</p><p><strong>Methods: </strong>Sixteen 8-month-old male Bama pigs underwent esophageal manometry to determine the precise anatomical positioning of the upper (UES) and lower esophageal sphincters (LES) relative to the incisor teeth, as well as their respective contraction intensities. The pigs were randomly allocated into three experimental groups (n = 6, 5, 5), with each group subjected to Dx PH-probe monitoring. In Group 1, animals were fasted for 24 hours and water-deprived for 6 hours before undergoing pH monitoring under anaesthesia. Group 2 was anaesthetised two hours post-normal feeding and subsequently monitored. Group 3 also received anaesthesia two hours after eating but were monitored in an awake state.</p><p><strong>Results: </strong>The mean distance from the UES to the incisor teeth was found to be 19.8 ± 1 cm, while the LES was located at 40 ± 2.5 cm. The resting pressure measurements revealed a mean value of 64 ± 12 mmHg for the UES and 20 ± 4 mmHg for the LES in Bama pigs. Laryngopharyngeal pH values across the three groups were 7 ± 0.6, 7 ± 0.5, and 7.4 ± 1.2, respectively, showing no significant differences or reflux events. Similarly, there was no statistically significant difference in the lower oesophageal pH between Group 1 and Group 2.</p><p><strong>Conclusions: </strong>The Bama pig emerges as a suitable animal model for studying LPRD, given its comparable physiological parameters. The feasibility of establishing a reflux model in Bama pigs and using it to investigate the underlying mechanisms of LPRD is convincingly supported by these findings.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"45 1","pages":"21-27"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete response of laryngeal papillomatosis after HPV vaccination.","authors":"Alberto Paderno, Isabelle Matilde Dohin, Francesca Gennarini","doi":"10.14639/0392-100X-N2990","DOIUrl":"10.14639/0392-100X-N2990","url":null,"abstract":"","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"70-72"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of body mass index as a predictor of dupilumab efficacy in patients with severe chronic rhinosinusitis with nasal polyps.","authors":"Letizia Nitro, Eugenio De Corso, Marco Borin, Alberto Maria Saibene, Flavio Arnone, Francesco Ferella, Giulia Gramellini, Alessandro Cantiani, Gabriele De Maio, Camilla Spanu, Alberto Giulio Dragonetti, Giovanni Felisati, Carlotta Pipolo","doi":"10.14639/0392-100X-N2841","DOIUrl":"10.14639/0392-100X-N2841","url":null,"abstract":"<p><strong>Objective: </strong>Response to dupilumab for chronic rhinosinusitis with nasal polyps, albeit almost always excellent, is still not predictable. Our study focuses on the role of body mass index (BMI) on the efficacy of dupilumab.</p><p><strong>Methods: </strong>We present a retrospective multicentre study of 106 patients on dupilumab, stratified in 3 subgroups of BMI. The main therapeutic outcomes investigated were Nasal Polyp Score (NPS), Sino-Nasal-Outcome Test - 22 (SNOT-22), Sniffin' Sticks Identification test and visuo-analogical scale, and the different timing of response, according to De Corso et al. criteria.</p><p><strong>Results: </strong>Dupilumab treatment led to a progressive improvement for all outcomes at all time points. Comparing the different metabolic subgroups, a late response in terms of decrease in NPS was observed only in 3 obese patients. A significant decrease was also found in SNOT-22 score at 6 and 12 months, which was less marked in overweight/obese patients.</p><p><strong>Conclusions: </strong>Our study confirmed the efficacy of dupilumab in each BMI subgroup. However, the efficacy seems to follow different timing with respect to patients' BMI. Our data suggest that patients with a compromised metabolic state present more severe disease at baseline and a possibly delayed response to dupilumab.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"45 1","pages":"28-38"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood and local nasal eosinophilia in chronic rhinosinusitis with nasal polyps: prevalence and correlation with severity of disease.","authors":"Eugenio De Corso, Marco Corbò, Claudio Montuori, Daniela Furno, Veronica Seccia, Tiziana Di Cesare, Carlotta Pipolo, Silvia Baroni, Rodolfo Mastrapasqua, Alberta Rizzuti, Giuseppe D'Agostino, Leandro Maria D'Auria, Maria Clara Pacilli, Jacopo Galli","doi":"10.14639/0392-100X-N2877","DOIUrl":"10.14639/0392-100X-N2877","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the clinical relevance of absolute eosinophil blood count and eosinophil count by nasal cytology in the context of real-life clinical practice and to determine if they correlate with the severity of symptoms in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).</p><p><strong>Methods: </strong>We enrolled 425 patients with CRSwNP followed between January 2015 and April 2023 at the A. Gemelli Hospital Foundation-IRCCS, Rome, Italy. We gathered data on blood and local eosinophil count and correlated the results with clinical features. All patients underwent endoscopy, Visual Analogical Scale (VAS) for main symptoms, and SinoNasal Outcome Test 22 (SNOT-22).</p><p><strong>Results: </strong>We observed significantly higher mean levels of eosinophils in serum and at nasal cytology in patients with CRSwNP and comorbidities (asthma, non-steroidal anti-inflammatory drugs - exacerbated respiratory disease and allergy) compared to those without. Blood eosinophilia was not associated with severity of symptoms, whereas patients with nasal eosinophil count > 5 eosinophils per high-power field at nasal cytology had a significantly higher median specific VAS for nasal symptoms and significantly higher SNOT 22 scores.</p><p><strong>Conclusions: </strong>We demonstrated that blood eosinophil count and nasal cytology may represent useful tools in routine clinical practice to define Type 2 inflammation and that their levels are usually higher in patients with comorbidities. We also showed that blood eosinophilia was not correlated with severity of symptoms, whereas local eosinophil count was associated with high severity of symptoms and high burden on quality of life.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"45 1","pages":"39-46"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications in 2000 adult and paediatric cochlear implants: what to expect and when.","authors":"Vittoria Sykopetrites, Eleonora Sica, Flavia Di Maro, Eliana Cristofari","doi":"10.14639/0392-100X-N2778","DOIUrl":"10.14639/0392-100X-N2778","url":null,"abstract":"<p><strong>Objective: </strong>To identify the incidence of intra- and postoperative complications of adult and paediatric cochlear implants (CIs) in a large cohort with long follow-up.</p><p><strong>Methods: </strong>Retrospective chart analysis of 2000 consecutive cases of CI in a single institution.</p><p><strong>Results: </strong>8.9% of paediatric CIs developed a complication after a mean period of 5.5 ± 5.8 years. 12% of adult CIs developed a complication after a mean period of 3.5 ± 5.3 years.</p><p><p>Seroma was the most frequent paediatric complication (1.8%), after a mean of 8.9 ± 5.4 years, while vertigo was the most common complaint in adults (2.5%), emerging in the first year. Both complications were generally managed conservatively. Acute otitis media or abscess with extrusion of the receiver/stimulator required surgical revision, with or without CI explantation, in 23.5% and 76.9% of cases, respectively. Cholesteatoma or chronic otitis media were always treated surgically and required CI explantation in 86.7% of cases. All cases complicated by device failure (1.2% and 0.8% of paediatric and adult CIs, respectively) were treated with CI explantation and reimplantation, and emerged after a mean of 5 ± 4 years.</p><p><strong>Conclusions: </strong>Knowledge and decades long monitoring of the complications related to CIs are fundamental.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"45 1","pages":"58-69"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous neck haemorrhage secondary to parathyroid adenoma: description of a case and systematic review.","authors":"Alberto Vito Marcuzzo, Sara Fadda, Kevin Cargnelutti, Simone Zucchini, Lara Bigolin, Pierluigi Bonini, Giancarlo Tirelli","doi":"10.14639/0392-100X-N3055","DOIUrl":"10.14639/0392-100X-N3055","url":null,"abstract":"<p><strong>Introduction: </strong>Parathyroid adenomas can rarely cause spontaneous haemorrhage, which can be life-threatening. Diagnosis is challenging. We present a case and systematic review to define a clearer pattern of symptoms, diagnosis, and treatment.</p><p><strong>Materials and methods: </strong>We conducted a literature search of PubMed, Google Scholar, and Embase using PRISMA guidelines, identifying 38 relevant case reports on spontaneous neck bleeding or haematoma caused by parathyroid adenomas from 1974 to 2020. Data included epidemiology, clinical features, and treatment. One patient treated at our clinic is described.</p><p><strong>Results: </strong>Reviewing 38 articles, we found cervical haematomas from spontaneous bleeding of parathyroid adenoma in 45 patients, comprising 33 women and 12 men. Common symptoms were neck pain, dysphagia, and swelling. Surgery was the primary treatment, with 4.4% requiring tracheotomy. Average hospital stay was 12.5 days, which was mostly complication-free.</p><p><strong>Conclusions: </strong>Parathyroid adenoma haemorrhage in middle-aged women with neck swelling, pain, and swallowing difficulty should be suspected. Diagnosis involves blood tests and contrast CT. Treatment is adenoma removal, typically without major complications.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"45 1","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and microbiological study of fungal rhinosinusitis treated with endoscopic surgery.","authors":"Vladan Milutinović, Aleksandar Trivić, Ivana Čolović-Čalovski, Jovica Milovanović, Sanja Colić, Snežana Babac, Nada Tomanović, Zorana Radin","doi":"10.14639/0392-100X-N2808","DOIUrl":"https://doi.org/10.14639/0392-100X-N2808","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to analyse the aetiology, clinical presentations, histopathology and microbiological aspects of fungal rhinosinusitis (FRS) in patients undergoing endoscopic surgery.</p><p><strong>Methods: </strong>The descriptive study was carried out over a 4-year period in two Serbian ENT Clinics and included patients with sinonasal pathology who underwent endoscopic surgery.</p><p><strong>Results: </strong>The study included 26 patients. The most common forms of FRS treated by endoscopic sinus surgery was allergic FRS (AFRS). The fungus identification rate varied between entities, and was 72.2% in AFRS and 33.3% in fungal ball specimens. The common species seen in AFRS isolates were <i>Cladosporium</i> spp. (38.5% of isolated) and dematiaceous molds in the same percentage, while the remainder of the cultures were hyaline moulds. CT scan can be very helpful in diagnosing FRS and sometimes even in differentiating between different entities. Treatment of FRS should be tailored for each entity. Postoperative medical treatment in AFRS should consider potential advancements described in the literature.</p><p><strong>Conclusions: </strong>This study emphasises the need to combine all types of clinical, radiology, pathohistological and microbiological methods to obtain the best diagnostic and treatment strategies and should be the basis for further research.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of IGF2BP2 and long non-coding RNA TUG1 for the prognosis and tumour microenvironment in head and neck squamous cell carcinoma.","authors":"Wenhui Yuan, Yuanzheng Qiu, Qinglai Tang, Mengmeng Li, Xiaojun Tang, Tao Yang","doi":"10.14639/0392-100X-N3024","DOIUrl":"https://doi.org/10.14639/0392-100X-N3024","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the role of m6A-related long non-coding RNAs (lncRNAs) in the prognosis and tumour microenvironment of head and neck squamous cell carcinoma (HNSCC).</p><p><strong>Methods: </strong>497 samples from The Cancer Genome Atlas were analysed to identify m6A-related lncRNAs via correlation models. Tripartite regression models, Kaplan-Meier analysis and nomograms were then utilised to assess the prognostic significance of these lncRNAs. Tumour mutation burden and immune cell infiltration analyses were also performed. Moreover, m6A-related lncRNAs expression and relation with IGF2BP2 were confirmed by RT-qPCR.</p><p><strong>Results: </strong>The risk model revealed that high-risk scores predicted poorer survival outcomes. The area under ROC curves for predicting 1-, 3-, 5-year survival in the training set were 0.70, 0.68, and 0.64, respectively. Seven key m6A-related lncRNAs showed associations with immune checkpoint molecules, especially CTLA4 and PD-1. Finally, we found that knockdown of TUG1 repressed the expression of IGF2BP2.</p><p><strong>Conclusions: </strong>Our results suggest that the m6A-related lncRNA risk model has potential clinical utility in predicting prognosis and immunotherapeutic responses in patients with HNSCC. Identification of candidate compounds for immunotherapy further emphasises the model's relevance in guiding treatment decisions for HNSCC.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}