Acta Otorhinolaryngologica Italica最新文献

{"title":"Combined treatment of muscle tension dysphonia: voice therapy with instrumental postural rehabilitation.","authors":"Pasqualina Maria Picciotti,&nbsp;Maria Raffaella Marchese,&nbsp;Ylenia Longobardi,&nbsp;Giuseppe Oliveto,&nbsp;Lea Calò,&nbsp;Lucia D'Alatri","doi":"10.14639/0392-100X-N2287","DOIUrl":"https://doi.org/10.14639/0392-100X-N2287","url":null,"abstract":"<p><strong>Objectives: </strong>This investigation aimed to propose a new rehabilitation technique that combines voice exercises and instrumental postural rehabilitation for patients with muscle tension dysphonia (MTD).</p><p><strong>Methods: </strong>We enrolled nine dysphonic patients (8 women and 1 man, aged 22-55 years). Voice assessment included strobovideolaryngoscopy, Maximum Phonation Time (MPT), perceptual evaluation by GRBAS scale and patient's self-rating by Italian version of the Voice Handicap Index (VHI). Vestibular function was evaluated by the Bed Side Examination and Video Head Impulse test (VHIT). Postural control was evaluated by Dynamic Posturography (DP) using the Sensory Organization Test (SOT) and analysing the Equilibrium Score (ES) and balance subsystems (somatosensorial, visual, vestibular).</p><p><strong>Results: </strong>All cases underwent different types of voice exercises combined with balance training based on NeuroCom Balance Master Protocols, once a week for six 35-minutes sessions. After therapy, an improvement in MPT, VHI, GRBAS scores and endoscopic laryngeal features was obtained. DP results at baseline were normal and after therapy we showed a slight improvement of ES (somatosensorial and visual components).</p><p><strong>Conclusions: </strong>A combined rehabilitation technique for MTD, by improving the attention to postural control, allows for significant improvement in vocal symptoms.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"245-251"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/6b/aoi-2023-04-245.PMC10366564.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9971522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type III laryngo-tracheo-oesophageal cleft repair without tracheostomy in neonate with long-gap oesophageal atresia.","authors":"Carlos Delgado-Miguel,&nbsp;Carlos De la Torre,&nbsp;Luis Castro,&nbsp;Francisco Hernández Oliveros","doi":"10.14639/0392-100X-N2517","DOIUrl":"https://doi.org/10.14639/0392-100X-N2517","url":null,"abstract":"Riparazione di una fistola laringo-tracheo-esofagea di tipo III senza tracheostomia in neonato con atresia esofagea estesa.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"291-293"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/96/aoi-2023-04-291.PMC10366560.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9973084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma.","authors":"Chiara Bianchini,&nbsp;Matteo Caracciolo,&nbsp;Luca Urso,&nbsp;Andrea Ciorba,&nbsp;Anna Bonsembiante,&nbsp;Andrea Migliorelli,&nbsp;Virginia Corazzi,&nbsp;Ilaria Carandina,&nbsp;Naima Ortolan,&nbsp;Corrado Cittanti,&nbsp;Licia Uccelli,&nbsp;Stefano Pelucchi,&nbsp;Stefano Panareo,&nbsp;Mirco Bartolomei","doi":"10.14639/0392-100X-N2370","DOIUrl":"https://doi.org/10.14639/0392-100X-N2370","url":null,"abstract":"<p><strong>Objective: </strong>The presence of cervical lymph node metastases (CLNM) at diagnosis is one of the most relevant negative prognostic factors in patients with head and neck squamous cell carcinoma (HNSCC). The aim of this study was to analyse 2-deoxy-2[¹⁸F]fluoro-D-glucose (FDG) PET/CT findings for the identification of primary tumours and CLNM in a sample of patients affected by HNSCC. Moreover, a maximum standardised uptake value (SUVmax) threshold for the detection of CLNM was estimated. Clinical variables (i.e. smoking and alcohol habits), and tumour features (i.e. EBV and HPV positivity) were also evaluated in relation to FDG PET/CT findings.</p><p><strong>Methods: </strong>We retrospectively analysed patients who underwent FDG PET/CT for HNSCC staging between 2015-2020 at the University Hospital of Ferrara. All patients had cytological or histological confirmation of suspected cervical lymph nodes.</p><p><strong>Results: </strong>In total, 65 patients were enrolled (53 males, 12 females, median age 65.7 years). CLNM of patients with smoking habit had significantly higher SUVmax values than those of patients with previous smoking habit and non-smokers (p = 0.04). p16 positive HNSCC demonstrated a trend for higher SUVmax values on CLNM, in comparison to p16 negative tumours (p = 0.089). ROC curve analysis identified 5.8 as the best cut-off value of SUVmax for the detection of CLNM (AUC = 0.62, sensitivity 71.4% and specificity 72.7%).</p><p><strong>Conclusions: </strong>FDG PET/CT is a useful tool to evaluate CLNM in patients with HNSCC, particularly in those with smoking habit and p16 positive disease. A SUVmax cut-off of 5.8, combined with the use of conventional radiological investigations, may represent a useful tool in the identification of CLNM.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"235-244"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/e9/aoi-2023-04-235.PMC10366561.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9971525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term complications associated with the management of sinonasal malignancies: a single center experience.","authors":"Einav G Levin,&nbsp;Sharon Tzelnick,&nbsp;Daniel Yaacobi,&nbsp;Igor Vainer,&nbsp;Aviram Mizrachi,&nbsp;Aron Popovtzer,&nbsp;Ethan Soudry","doi":"10.14639/0392-100X-N1902","DOIUrl":"https://doi.org/10.14639/0392-100X-N1902","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to review the long-term complications associated with treatment of patients with sinonasal malignancies (SNMs) and risk factors for these complications.</p><p><strong>Methods: </strong>A retrospective analysis of all patients treated for SNMs at a tertiary care center between 2001 and 2018. A total of 77 patients were included. The primary outcome measure was post-treatment long-term complications.</p><p><strong>Results: </strong>Overall, long-term complications were identified in 41 patients (53%), and the most common were sinonasal (22 patients, 29%) and orbital/ocular-related (18 patients, 23%). In a multivariate regression analysis, irradiation was the only significant predictor of long-term complications (p = 0.001, OR = 18.86, CI = 3.31-107.6). No association was observed between long-term complications and tumour stage, surgical modality, or radiation dose/modality. Mean radiation dose ≥ 50 Gy to the optic nerve was associated with grade ≥ 3 visual acuity impairment (100% <i>vs</i> 3%; p = 0.006). Radiation therapy for disease recurrence was associated with additional long-term complications (56% <i>vs</i> 11%; p = 0.04).</p><p><strong>Conclusions: </strong>Treatment of SNMs has substantial long-term complications, which are significantly associated with radiation therapy.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 3","pages":"203-211"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/57/aoi-2023-03-203.PMC10198366.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does vestibular function correlate with objective MRI findings after vestibular schwannoma surgery?","authors":"Zuzana Balatková,&nbsp;Markéta Bonaventurová,&nbsp;Rudolf Černý,&nbsp;Jiří Lisý,&nbsp;Silvie Brennerová,&nbsp;Vladimír Koucký,&nbsp;Veronika Bandúrová,&nbsp;Veronika Svobodová,&nbsp;Zdeněk Fík,&nbsp;Martin Komarc,&nbsp;Eva Mrázková,&nbsp;Klára Kučerová,&nbsp;Pavel Hermann,&nbsp;Zdeněk Čada","doi":"10.14639/0392-100X-N2367","DOIUrl":"https://doi.org/10.14639/0392-100X-N2367","url":null,"abstract":"<p><strong>Objective: </strong>Vestibular schwannoma surgery leads to acute unilateral vestibular loss. In some patients, however, the process of post-operatively initiated central compensation proceeds more rapidly than in others. This study aimed to evaluate post-operative vestibular function and correlate it with morphological findings of MRI scans.</p><p><strong>Methods: </strong>The study included 29 patients who underwent surgery for vestibular schwannoma. Vestibular function was analysed post-operatively by video head impulse test (vHIT). Subjective symptoms were evaluated using validated questionnaires. All patients underwent MRI 3 months post-operatively, and the presence of the facial and vestibulocochlear nerves in the internal auditory canal was assessed.</p><p><strong>Results: </strong>The vestibulo-ocular reflex gain measured by the vHIT correlated positively with audiological findings. Subjective perception of vestibular disorder did not correlate with objectively measured vestibular impairment or with MRI findings.</p><p><strong>Conclusions: </strong>After the resection of vestibular schwannoma, some patients may still have preserved vestibular function as measured by vHIT. The preserved function does not correlate with subjective symptoms. Patients with partially deteriorated vestibular function showed lower sensitivity to combined stimuli.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 3","pages":"212-220"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/49/aoi-2023-03-212.PMC10198369.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of bone conduction hearing aid in children with unilateral aural atresia.","authors":"Davide Brotto,&nbsp;Flavia Sorrentino,&nbsp;Diego Cazzador,&nbsp;Francesca Maritan,&nbsp;Silvia Montino,&nbsp;Anna Agostinelli,&nbsp;Elisabetta Zanoletti,&nbsp;Alessandro Martini,&nbsp;Roberto Bovo,&nbsp;Patrizia Trevisi","doi":"10.14639/0392-100X-N2271","DOIUrl":"https://doi.org/10.14639/0392-100X-N2271","url":null,"abstract":"<p><strong>Objective: </strong>To assess the hearing benefit with a unilateral bone conduction hearing aid in a cohort of children with unilateral aural atresia.</p><p><strong>Methods: </strong>Cross-sectional case series pilot study involving 7 children (median age: 10 years, range 6-11). All patients underwent pure-tone, speech, aided sound field and aided speech audiometry and Simplified Italian Matrix Test (SIMT) with and without bone conduction hearing aid (Baha 5^® Cochlear^TM). Cognitive abilities were assessed in 5 patients.</p><p><strong>Results: </strong>The mean air conduction pure-tone average (PTA) of the atretic ear was 63.2 ± 6.9 dB, while the bone conduction PTA was 12.6 ± 4.7 dB. Speech discrimination score of the atretic ear was 88.6 ± 3.8 dB, while with the hearing aid it was 52.8 ± 1.9 dB. In the contralateral ear, there was no significant air-bone gap, and PTAs for air and bone conduction thresholds were within normal range (PTA ≤ 25 dB). The mean aided air conduction hearing threshold was 26.2 ± 7.97. Mean speech recognition threshold without the hearing aid was -5.1 ± 1.9 dB, and -6.0 ± 1.7 dB with the hearing aid tested with the SIMT. The mean score of the cognitive test was 46.8 ± 42.8.</p><p><strong>Conclusions: </strong>These preliminary findings should encourage clinicians in proposing a unilateral bone conduction hearing aid in children with unilateral atresia.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 3","pages":"221-226"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/4f/aoi-2023-03-221.PMC10198364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral selective laryngeal reinnervation in patients with bilateral vocal cord palsy.","authors":"Roberto Puxeddu,&nbsp;Valeria Marrosu,&nbsp;Marta Filauro,&nbsp;Cinzia Mariani,&nbsp;Giampiero Parrinello,&nbsp;Kate Heathcote,&nbsp;Clara Gerosa,&nbsp;Melania Tatti,&nbsp;Stefano Manca di Villahermosa,&nbsp;Francesco Mora,&nbsp;Giorgio Peretti,&nbsp;Filippo Carta","doi":"10.14639/0392-100X-N2395","DOIUrl":"https://doi.org/10.14639/0392-100X-N2395","url":null,"abstract":"<p><strong>Objective: </strong>Bilateral selective reinnervation of the larynx aims to restore both vocal cord tone and abductor movements in patients with bilateral vocal cord palsy.</p><p><strong>Methods: </strong>Four females and one male treated by bilateral selective reinnervation of the larynx were included in the present study. In all cases, both posterior cricoarytenoid muscles were reinnervated using the C3 right phrenic nerve root through the great auricular nerve graft, while adductor muscle tone was bilaterally restored using the thyrohyoid branches of the hypoglossal nerve through transverse cervical nerve grafts.</p><p><strong>Results: </strong>After a minimum follow-up of 48 months, all patients were successfully tracheostomy free and had recovered normal swallowing. At laryngoscopy, the first patient recovered a left unilateral partial abductor movement, the second had complete bilateral abductor movements, the third did not show improvements of abductor movements, but symptomatology was improved, the fourth recovered partial bilateral abductor movements and the fifth case did not show improvements and needed posterior cordotomy.</p><p><strong>Conclusions: </strong>Bilateral selective laryngeal reinnervation, although a complex surgical procedure, offers a more physiologic recovery in the treatment of bilateral vocal fold paralysis. Selection criteria still needs to be precisely defined to avoid unexpected failures.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 3","pages":"189-196"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/9d/aoi-2023-03-189.PMC10198368.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasopharyngeal carcinoma. A \"different\" head and neck tumour. Part B: treatment, prognostic factors, and outcomes.","authors":"Giulio Cantù","doi":"10.14639/0392-100X-N2223","DOIUrl":"https://doi.org/10.14639/0392-100X-N2223","url":null,"abstract":"SUMMARY Nasopharyngeal carcinoma (NPC) is the most interesting and intriguing malignant tumour located in the nasopharynx, because it is a “peculiar” malignancy, “different” from almost all the other head and neck tumours according to several points of view. Given that radiotherapy (RT) is the treatment of choice for NPC, chemotherapy (CT) has been added to standard RT to improve outcome in high-risk patients, either as an adjuvant, neoadjuvant or concurrent treatment modality with radiation. Surgery plays an important role in rescuing recurrent or persistent disease after primary (CT)RT. This second part of the review provides a critical analysis of various treatment described in the literature, both for primary cancer and for regional and distant metastases. The prognostic factors and the final results of the various treatments will also be analysed.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 3","pages":"155-169"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/ef/aoi-2023-03-155.PMC10198365.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9915803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic-nutritional index in HPV-negative head and neck squamous cell carcinoma treated with upfront surgery: a multi-institutional series.","authors":"Michele Tomasoni,&nbsp;Cesare Piazza,&nbsp;Alberto Deganello,&nbsp;Paolo Bossi,&nbsp;Giancarlo Tirelli,&nbsp;Piero Nicolai,&nbsp;Maria Cristina Da Mosto,&nbsp;Gabriele Molteni,&nbsp;Vittorio Giacomarra,&nbsp;Pietro Canzi,&nbsp;Stefano Pelucchi,&nbsp;Jerry Polesel,&nbsp;Daniele Borsetto,&nbsp;Paolo Boscolo-Rizzo","doi":"10.14639/0392-100X-N2358","DOIUrl":"https://doi.org/10.14639/0392-100X-N2358","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the prognostic value of pre-treatment prognostic-nutritional index (PNI) in patients with HPV-negative head and neck squamous cell carcinoma (HNSCC).</p><p><strong>Methods: </strong>A multi-institutional retrospective series of HPV-negative, Stages II-IVB, HNSCCs treated with upfront surgery was evaluated. Correlation of pre-operative blood markers and PNI with 5-year overall (OS) and relapse-free (RFS) survival was tested using linear and restricted cubic spline models, as appropriate. The independent prognostic effect of patient-related features was assessed with multivariable models.</p><p><strong>Results: </strong>The analysis was conducted on 542 patients. PNI ≥ 49.6 (HR = 0.52; 95% CI, 0.37-0.74) and Neutrophil-to-Lymphocyte Ratio (NLR) > 4.2 (HR = 1.58; 95% CI, 1.06-2.35) confirmed to be independent prognosticators of OS, whereas only PNI ≥ 49.6 (HR = 0.44; 95% CI, 0.29-0.66) was independently associated with RFS. Among pre-operative blood parameters, only higher values of albuninaemia and lymphocyte count (> 1.08 x 10³/microL), and undetectable basophile count (= 0 10³/microL) were independently associated with better OS and RFS.</p><p><strong>Conclusions: </strong>PNI represents a reliable prognostic tool providing an independent measure of pre-operative immuno-metabolic performance. Its validity is supported by the independent prognostic role of albuminaemia and lymphocyte count, from which it is derived.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 3","pages":"170-182"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/43/aoi-2023-03-170.PMC10198367.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9915806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TSH level as a risk factor of thyroid malignancy for nodules in euthyroid patients.","authors":"Abdulaziz K Alaraifi,&nbsp;Mohammed Alessa,&nbsp;Leen O Hijazi,&nbsp;Areej M Alayed,&nbsp;Abdulaziz A Alsalem","doi":"10.14639/0392-100X-N2288","DOIUrl":"https://doi.org/10.14639/0392-100X-N2288","url":null,"abstract":"<p><strong>Objective: </strong>With the increased prevalence of incidental thyroid cancer, determining the predictors of thyroid malignancy has become a source of debate. This study aimed to determine the impact of thyroid stimulating hormone (TSH) levels on rates of thyroid cancer in euthyroid patients.</p><p><strong>Methods: </strong>A retrospective study included 421 patients who underwent thyroidectomy at a tertiary hospital between 2016 and 2020. Patients' demographics, history of cancer, pre-operative workup and final histology reports were obtained. The study sample was divided into two groups based on the final histopathology (benign <i>vs</i> malignant). The two groups were compared using the appropriate statistical tests to determine the predictors of thyroid cancer in euthyroid patients.</p><p><strong>Results: </strong>TSH levels were significantly higher in patients with malignant nodules compared to those with benign nodules (1.94 <i>vs</i> 1.62, p = 0.002). It was 1.54 times more likely for thyroid nodules to be malignant when TSH levels were higher (p = 0.038). Meanwhile, larger nodules (> 4 cm) were significantly more prevalent in benign nodules (43.1%) than in malignant nodules (21.1%). Larger nodules decreased the possibility of thyroid cancer by 24% (OR = 0.760, p-value = 0.004).</p><p><strong>Conclusions: </strong>High TSH levels in euthyroid patients were significantly correlated with the risk of thyroid malignancy. In addition, as Bethesda category proceeded toward malignancy, TSH levels increased. High TSH levels and small nodule diameters can be used as additional parameters in predicting thyroid cancer in euthyroid patients.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 3","pages":"183-188"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/50/aoi-2023-03-183.PMC10198371.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9915805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}