Gabriele Zigliani, Sara Migliorati, Elisa Marazzi, Mara Arcuri, Michele Tomasoni, Simonetta Battocchio, Alberto Paderno, Davide Lancini, Alberto Deganello, Cesare Piazza
{"title":"Adenosquamous cell carcinoma of the head and neck: a retrospective single institution series.","authors":"Gabriele Zigliani, Sara Migliorati, Elisa Marazzi, Mara Arcuri, Michele Tomasoni, Simonetta Battocchio, Alberto Paderno, Davide Lancini, Alberto Deganello, Cesare Piazza","doi":"10.14639/0392-100X-N2466","DOIUrl":"10.14639/0392-100X-N2466","url":null,"abstract":"<p><strong>Objectives: </strong>Head and neck adenosquamous cell carcinoma (HN-ASCC) is a rare, aggressive neoplasm, with limited data reported in the literature. The aim of this study was to assess tumour behaviour and prognostic factors impacting overall survival (OS) in a retrospective, single institution series.</p><p><strong>Methods: </strong>A retrospective study on patients affected by HN-ASCC who were treated surgically between 2002 and 2019 at the Department of Otorhinolaryngology - Head and Neck Surgery of the University of Brescia was conducted. Demographics, clinical data, OS, and relative prognostic factors were analysed.</p><p><strong>Results: </strong>The study included 32 patients, with a median age of 66 years, mostly males (84.4%) and untreated (68.8%). Adjuvant treatments followed surgery in 28.1% of patients. Compared to conventional SCC, ASCC showed a higher proportion of cases arising in the larynx (40.6%); no difference was found in other features. Advanced (pT3-4) local stage at presentation (p = 0.023), perineural invasion (PNI, p = 0.01), and positive margins (p = 0.007) were independent negative prognostic factors for OS.</p><p><strong>Conclusions: </strong>HN-ASCC is a rare, aggressive cancer, most frequently arising in the larynx of elderly males, usually diagnosed in an advanced local stage. OS is generally poor, affected by local advanced stage, PNI, and positive resection margins.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"310-316"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/66/aoi-2023-05-310.PMC10551728.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Raffaella Marchese, Federico Sensoli, Silvia Campagnini, Matteo Cianchetti, Andrea Nacci, Francesco Ursino, Lucia D'Alatri, Jacopo Galli, Maria Chiara Carrozza, Gaetano Paludetti, Andrea Mannini
{"title":"Artificial intelligence for the recognition of benign lesions of vocal folds from audio recordings.","authors":"Maria Raffaella Marchese, Federico Sensoli, Silvia Campagnini, Matteo Cianchetti, Andrea Nacci, Francesco Ursino, Lucia D'Alatri, Jacopo Galli, Maria Chiara Carrozza, Gaetano Paludetti, Andrea Mannini","doi":"10.14639/0392-100X-N2309","DOIUrl":"10.14639/0392-100X-N2309","url":null,"abstract":"<p><strong>Objective: </strong>The diagnosis of benign lesions of the vocal fold (BLVF) is still challenging. The analysis of the acoustic signals through the implementation of machine learning models can be a viable solution aimed at offering support for clinical diagnosis.</p><p><strong>Materials and methods: </strong>In this study, a support vector machine was trained and cross-validated (10-fold cross-validation) using 138 features extracted from the acoustic signals of 418 patients with polyps, nodules, oedema, and cysts. The model's performance was presented as accuracy and average F1-score. The results were also analysed in male (M) and female (F) subgroups.</p><p><strong>Results: </strong>The validation accuracy was 55%, 80%, and 54% on the overall cohort, and in M and F, respectively. Better performances were observed in the detection of cysts and nodules (58% and 62%, respectively) vs polyps and oedema (47% and 53%, respectively). The results on each lesion and the different patterns of the model on M and F are in line with clinical observations, obtaining better results on F and detection of sensitive polyps in M.</p><p><strong>Conclusions: </strong>This study showed moderately accurate detection of four types of BLVF using acoustic signals. The analysis of the diagnostic results on gender subgroups highlights different behaviours of the diagnostic model.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"317-323"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/a6/aoi-2023-05-317.PMC10551729.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dental impression silicone putty in transoral laser laryngeal surgery: prevention of oral complications.","authors":"Niccolò Cerchiai, Valentina Mancini, Miriana Picariello, Giandomenico Maggiore, Luca Muscatello, Paolo Iannicelli, Gianluca Leopardi","doi":"10.14639/0392-100X-N2543","DOIUrl":"10.14639/0392-100X-N2543","url":null,"abstract":"<p><strong>Objective: </strong>To describe a new method to improve the exposure of the surgical field and to protect the oral cavity during transoral laser micro-surgery (TOLMS) of the larynx.</p><p><strong>Methods: </strong>Dental Impression Silicone Putty (DISP) was employed as an alternative to traditional mouthguards.</p><p><strong>Results: </strong>DISP mouthguards perfectly fit to each patient, reduce encumbrance in the mouth, and reduce pressure on the teeth; disadvantages are minimal.</p><p><strong>Conclusions: </strong>Although clinical studies are necessary to demonstrate the efficacy of the method in reducing the incidence of oral complications, DISP mouthguards represent a significant aid for laryngeal exposure.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"348-351"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/f8/aoi-2023-05-348.PMC10551730.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9519010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto Teggi, Marco Familiari, Rosa Alessia Battista, Omar Gatti, Iacopo Cangiano, Mario Bussi, Luciano Bubbico
{"title":"The social problem of presbystasis and the role of vestibular rehabilitation in elderly patients: a review.","authors":"Roberto Teggi, Marco Familiari, Rosa Alessia Battista, Omar Gatti, Iacopo Cangiano, Mario Bussi, Luciano Bubbico","doi":"10.14639/0392-100X-N1908","DOIUrl":"https://doi.org/10.14639/0392-100X-N1908","url":null,"abstract":"SUMMARY The term “presbystasis” refers to a common clinical condition in the elderly, characterised by a multifactorial and progressive impairment of balance. The pathophysiology may be related to various concomitant factors including central nervous system diseases, peripheral neuropathy, osteoarticular disorders (leading to a reduction of the speed gait), and cardiovascular or visual disorders, but it may also be a consequence of deficits of the peripheral or central vestibular system (which is generally represented by a bilateral and symmetric vestibular dysfunction). Benign paroxysmal positional vertigo (BPPV) is far from being rare in subjects over the age of 70 years. Nowadays, presbystasis represents one of the main causes of accidental falls in the elderly, leading to a reduction in quality of life and life expectancy. The aim of our work was to review the current literature on presbystasis, focusing on the role of the vestibular system in the pathogenesis and on the possibilities offered by vestibular rehabilitation in the management of these subjects. Other clinical conditions related to the disorder are also discussed.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"227-234"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/28/aoi-2023-04-227.PMC10366565.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10274594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giuseppe Malafronte, Barbara Filosa, Antonio Trusio, Generoso De Cristofaro, Vito Colacurcio, Pasquale Marra
{"title":"Stapedoplasty without sedation in an office-based setting.","authors":"Giuseppe Malafronte, Barbara Filosa, Antonio Trusio, Generoso De Cristofaro, Vito Colacurcio, Pasquale Marra","doi":"10.14639/0392-100X-N2549","DOIUrl":"https://doi.org/10.14639/0392-100X-N2549","url":null,"abstract":"Stapedoplastica senza sedazione effettuata in regime ambulatoriale.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"294-296"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/ff/aoi-2023-04-294.PMC10366559.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9918892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Italian validation of the Hearing Handicap Inventory for Elderly - Screening version (HHIE-S-It).","authors":"Enrico Apa, Luca Sacchetto, Silvia Palma, Chiara Cocchi, Chiara Gherpelli, Elisabetta Genovese, Daniele Monzani, Riccardo Nocini","doi":"10.14639/0392-100X-N2297","DOIUrl":"https://doi.org/10.14639/0392-100X-N2297","url":null,"abstract":"<p><strong>Objective: </strong>Validate the Italian version of the Hearing Handicap Inventory for Elderly - Screening version (HHIE-S-It).</p><p><strong>Methods: </strong>After translation, psychometric properties and attributes were analysed by administering the HHIE-S-It to 167 elderly outpatients together with the Psychological General Well-Being Index (PGWBI).</p><p><strong>Results: </strong>The Cronbach's α coefficient was 0.908 for the total score, and 0.832 and 0.816 for its two subscales. Significant test-retest reliability was observed (p < 0.001). Moderate to high correlations were found between HHIE-S-It and pure tone average in the better ear (p < 0.001). The ANOVA test confirmed the significant difference in HHIE-S-It scores across groups according to the degree of hearing loss (p < 0.001). Only very low and low significant correlations were observed between HHIE-S-It and PGWBI. The criterion HHIE-S-It > 11 was observed as the best cut-off with highest sensitivity (86.4%), specificity (72.4%), positive predictive value (52.8%), negative predictive value (93.7%) and likelihood ratios (3.12 and 0.19).</p><p><strong>Conclusions: </strong>Since the HHIE-S-It presented acceptable psychometric properties, its adoption is justified for both clinical and research purposes. Acceptable diagnostic attributes allow its use as a screening tool for age-related hearing loss.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"262-272"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/a4/aoi-2023-04-262.PMC10366563.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9973079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pietro Canzi, Elena Carlotto, Anna Simoncelli, Elvis Lafe, Andrea Scribante, Domenico Minervini, Matteo Nardo, Stefano Malpede, Luisa Chiapparini, Marco Benazzo
{"title":"The usefulness of the O-MAR algorithm in MRI skull base assessment to manage cochlear implant-related artifacts.","authors":"Pietro Canzi, Elena Carlotto, Anna Simoncelli, Elvis Lafe, Andrea Scribante, Domenico Minervini, Matteo Nardo, Stefano Malpede, Luisa Chiapparini, Marco Benazzo","doi":"10.14639/0392-100X-N2434","DOIUrl":"https://doi.org/10.14639/0392-100X-N2434","url":null,"abstract":"<p><strong>Objective: </strong>To assess artifact size and MRI visibility when applying the \"Orthopedic-Metal Artifact Reduction\" (O-MAR) algorithm for cochlear implant (CI) scanning.</p><p><strong>Methods: </strong>Two volunteers were submitted to 1.5 T MRI with an Ultra 3D CI receiver stimulator placed on their head. Four angular CI orientations were adopted: 90, 120, 135 and 160 degrees. Volunteers were scanned in each condition using T1w and T2w TSE sequences, as well as O-MAR sequences, in both axial and coronal planes. Quantitative comparisons were made of signal void and penumbra extent. Additionally, qualitative evaluations of global image quality, MRI readability with respect to 12 anatomical structures and visibility through the penumbra were undertaken.</p><p><strong>Results: </strong>After application of the O-MAR protocol, the radius of the signal void reduced from 50.76 mm to 45.43 mm and from 49.22 mm to 40.15 mm on T1w and T2w TSE axial sequences, respectively (p < 0.05). Qualitatively, sequences acquired with O-MAR produced better outcomes in terms of image quality and anatomical depiction. Despite the area of the penumbra being increased for the O-MAR protocol, visibility through penumbra was improved.</p><p><strong>Conclusions: </strong>Application of O-MAR may provide a complementary strategy to those already in use to obtain diagnostically useful MRI examinations in the presence of a CI, especially in case of skull base diseases requiring MRI monitoring.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"273-282"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/9d/aoi-2023-04-273.PMC10366562.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9918891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Paderno, Francesca Pia Villani, Milena Fior, Giulia Berretti, Francesca Gennarini, Gabriele Zigliani, Emanuela Ulaj, Claudia Montenegro, Alessandra Sordi, Claudio Sampieri, Giorgio Peretti, Sara Moccia, Cesare Piazza
{"title":"Instance segmentation of upper aerodigestive tract cancer: site-specific outcomes.","authors":"Alberto Paderno, Francesca Pia Villani, Milena Fior, Giulia Berretti, Francesca Gennarini, Gabriele Zigliani, Emanuela Ulaj, Claudia Montenegro, Alessandra Sordi, Claudio Sampieri, Giorgio Peretti, Sara Moccia, Cesare Piazza","doi":"10.14639/0392-100X-N2336","DOIUrl":"https://doi.org/10.14639/0392-100X-N2336","url":null,"abstract":"<p><strong>Objective: </strong>To achieve instance segmentation of upper aerodigestive tract (UADT) neoplasms using a deep learning (DL) algorithm, and to identify differences in its diagnostic performance in three different sites: larynx/hypopharynx, oral cavity and oropharynx.</p><p><strong>Methods: </strong>A total of 1034 endoscopic images from 323 patients were examined under narrow band imaging (NBI). The Mask R-CNN algorithm was used for the analysis. The dataset split was: 935 training, 48 validation and 51 testing images. Dice Similarity Coefficient (Dsc) was the main outcome measure.</p><p><strong>Results: </strong>Instance segmentation was effective in 76.5% of images. The mean Dsc was 0.90 ± 0.05. The algorithm correctly predicted 77.8%, 86.7% and 55.5% of lesions in the larynx/hypopharynx, oral cavity, and oropharynx, respectively. The mean Dsc was 0.90 ± 0.05 for the larynx/hypopharynx, 0.60 ± 0.26 for the oral cavity, and 0.81 ± 0.30 for the oropharynx. The analysis showed inferior diagnostic results in the oral cavity compared with the larynx/hypopharynx (p < 0.001).</p><p><strong>Conclusions: </strong>The study confirms the feasibility of instance segmentation of UADT using DL algorithms and shows inferior diagnostic results in the oral cavity compared with other anatomic areas.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"283-290"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/49/aoi-2023-04-283.PMC10366566.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9918893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arianna Cardella, Giuseppe Riva, Andrea Preti, Andrea Albera, Livio Luzi, Roberto Albera, Davide Cadei, Gian Marco Motatto, Filippo Omenetti, Giancarlo Pecorari, Francesco Ottaviani, Francesco Mozzanica
{"title":"Italian version of the Brief Questionnaire of Olfactory Disorders (Brief-IT-QOD).","authors":"Arianna Cardella, Giuseppe Riva, Andrea Preti, Andrea Albera, Livio Luzi, Roberto Albera, Davide Cadei, Gian Marco Motatto, Filippo Omenetti, Giancarlo Pecorari, Francesco Ottaviani, Francesco Mozzanica","doi":"10.14639/0392-100X-N2212","DOIUrl":"https://doi.org/10.14639/0392-100X-N2212","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the reliability and validity of the Italian version of the Brief Questionnaire of Olfactory Disorders (Brief-IT-QOD).</p><p><strong>Methods: </strong>The study consisted of six phases: item generation, reliability analysis (112 dysosmic patients for internal consistency analysis and 61 for test-retest reliability analysis), normative data generation (303 normosmic subjects), validity analysis (comparison of Brief-IT-QOD scores of healthy and dysosmic subjects and scores correlation with psychophysical olfactory testing TDI and SNOT-22 scores), responsiveness analysis (10 dysosmic chronic rhinosinusitis with nasal polyps patients before and after biologic therapy), and cut-off value determination (ROC curve analysis of Brief-IT-QOD sensitivity and specificity).</p><p><strong>Results: </strong>All subjects completed the Brief-IT-QOD. Internal consistency (α > 0.70) and test-retest reliability (ICC > 0.7) were acceptable and satisfactory for both questionnaire subscales. A significant difference between dysosmic and control subjects was found in both subscales (p < 0.05). Significant correlations between subscales scores and TDI and SNOT-22 scores were observed. Brief-IT-QOD scores before treatment were significantly higher than after biological therapy.</p><p><strong>Conclusions: </strong>Brief-IT-QOD is reliable, valid, responsive to changes in QoL, and recommended for clinical practice and outcome research.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 4","pages":"252-261"},"PeriodicalIF":2.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/0b/aoi-2023-04-252.PMC10366567.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10274600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}