{"title":"Treatment and outcomes of minor salivary gland cancers of the larynx and trachea: a systematic review.","authors":"Claudia Montenegro, Davide Mattavelli, Davide Lancini, Alberto Paderno, Elisa Marazzi, Vittorio Rampinelli, Michele Tomasoni, Cesare Piazza","doi":"10.14639/0392-100X-N2635","DOIUrl":"10.14639/0392-100X-N2635","url":null,"abstract":"<p><strong>Objectives: </strong>Malignant minor salivary glands carcinomas (MiSGC) of the larynx and trachea are rare tumours and published evidence is sparse. We conducted a systematic review to describe shareable treatment strategies and oncological outcomes of these neoplastic entities.</p><p><strong>Methods: </strong>Full text English manuscripts published from January 1<sup>st</sup> 2000 to December 14<sup>th</sup> 2022 were included. Data on demographics, treatments and outcomes were collected. A pooled analysis of 5-year overall survival (OS) was performed.</p><p><strong>Results: </strong>Seventeen articles and 365 patients met the inclusion criteria. The most common subsites involved were subglottic and distal trachea. Adenoid cystic carcinoma was, by far, the most frequent histotype. The first-choice treatment strategy was surgery (86.8%), while adjuvant treatments were delivered in 57.4% of patients. Only 12.9% were treated with definitive radiotherapy with/without chemotherapy. The mean follow-up was 68.3 months. One hundred nine (34.9%) deaths were recorded and 62.4% were cancer-related. Five-year OS ranged from 20% to 100% and, at pooled analysis, it was 83% (range, 78-87%).</p><p><strong>Conclusions: </strong>In case of MiSGC of the larynx and trachea, surgery remains the mainstay of treatment. Adjuvant treatments are frequently delivered. Survival estimates are good overall, but highly heterogeneous.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"365-374"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of middle ear function after conventional or endoscopic microdebrider assisted adenoidectomy.","authors":"Oj Giri, S Vijendra Shenoy, Navya Parvathareddy, Praneetha Puvvula, Deeksha Shetty, Nayanika Reddy","doi":"10.14639/0392-100X-N2593","DOIUrl":"10.14639/0392-100X-N2593","url":null,"abstract":"<p><strong>Objectives: </strong>To compare pre- and post-operative pure tone audiometric and impedance audiometric analysis following conventional and endoscopic microdebrider assisted adenoidectomy and compare the outcomes.</p><p><strong>Methods: </strong>Patients diagnosed with chronic adenoiditis were divided in groups of 25 each. Patients in the first group underwent conventional curettage adenoidectomy, while those in second group underwent endoscopic microdebrider assisted adenoidectomy. Pre- and post-operative pure tone and impedance audiometry were performed for all patients and outcomes were compared.</p><p><strong>Results: </strong>The endoscopic microdebrider assisted method resulted in significantly better outcomes compared to conventional curettage. Criteria such as hearing threshold (p value 0.004 at second follow-up), peak pressure (p value 0.045 at first follow-up) and tympanogram (p value 0.016) showed that the endoscopic method was better, while peak compliance (p value 0.340 at first follow-up) did not show any significant difference between groups.</p><p><strong>Conclusions: </strong>The endoscopic microdebrider assisted method for adenoidectomy has a definite advantage of better visualisation resulting in better clearance of tissue, leading to enhanced middle ear function compared to conventional curettage.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"417-423"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michaela Plath, Matthias Sand, Carlo Cavaliere, Peter K Plinkert, Ingo Baumann, Karim Zaoui
{"title":"Normative data for interpreting the SNOT-22.","authors":"Michaela Plath, Matthias Sand, Carlo Cavaliere, Peter K Plinkert, Ingo Baumann, Karim Zaoui","doi":"10.14639/0392-100X-N2279","DOIUrl":"10.14639/0392-100X-N2279","url":null,"abstract":"<p><strong>Objectives: </strong>The Sino-Nasal Outcome Test 22 (SNOT-22) is a validated patient-reported outcome instrument to evaluate the health-related quality of life (HRQoL) in patients with chronic rhinosinusitis (CRS). There are no published normative SNOT-22 scores, limiting its interpretation.</p><p><strong>Methods: </strong>Symptom scores from 1,000 SNOT-22 questionnaires were analysed by principal component analysis (PCA) and exploratory factor analyses. Data were derived from a survey with 1,000 healthy Europeans (reference cohort) who were recruited using the Respondi panel for market and social science research. This subsample was quoted to the population distribution of the German Microcensus and selected from a non-probability panel.</p><p><strong>Results: </strong>The overall normative SNOT-22 score can be detected to be 20.2 ± 19.44. Male (18.49 ± 19.15) and older (> 50 years old; 18.3 ± 17.49) participants had overall lower SNOT-22 mean results than females (21.8 ± 19.6) and younger (21.4 ± 20.55) participants, indicating higher levels of satisfaction. PCA proposed two SNOT-22 domains (\"physiological well-being\" and \"psychological well-being\"), which explained 65% of the variance.</p><p><strong>Conclusions: </strong>These are the first published (German) normative scores for the SNOT-22 and provide a clinical reference point for the interpretation of data.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"390-399"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spyridon Lygeros, Gerasimos Danielides, George C Kyriakopoulos, Foteini Tsapardoni, Katerina Grafanaki, Constantinos Stathopoulos, Vasileios Danielides
{"title":"Expression profiles of MMP-9 and EMMPRIN in chronic rhinosinusitis with nasal polyps.","authors":"Spyridon Lygeros, Gerasimos Danielides, George C Kyriakopoulos, Foteini Tsapardoni, Katerina Grafanaki, Constantinos Stathopoulos, Vasileios Danielides","doi":"10.14639/0392-100X-N2197","DOIUrl":"10.14639/0392-100X-N2197","url":null,"abstract":"<p><strong>Objective: </strong>Metalloproteinases (MMPs) are implicated in tissue remodeling in chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to evaluate the expression profiles of MMP-9 and the extracellular matrix metalloproteinase inducer (EMMPRIN) in nasal polyps compared to healthy mucosa.</p><p><strong>Methods: </strong>Tissue samples from 37 CRSwNP patients undergoing functional endoscopic sinus surgery and mucosal specimens from 12 healthy controls were obtained intra-operatively. MMP-9 and EMMPRIN mRNA levels were assessed by reverse transcription-polymerase chain reaction and their protein expression by Western blot analysis.</p><p><strong>Results: </strong>MMP-9 mRNA expression levels were significantly elevated in CRSwNP compared to controls (p < 0.05). MMP-9 protein levels presented an increasing trend but with no statistical significance (p > 0.05). No statistically significant difference in EMMPRIN mRNA and protein levels was identified.</p><p><strong>Conclusions: </strong>Upregulation of MMP-9 in nasal polyps is evident and highlights its role in the pathogenesis of CRSwNP. The lack of concordance between MMP-9 mRNA and protein levels may be attributed to post-translational gene expression regulation. Although EMMPRIN expression was not significantly different between the two groups, its role remains to be elucidated. MMP-9 may be a valuable biomarker and treatment target in CRSwNP.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"400-408"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Paderno, Francesca Pia Villani, Alessandra Sordi, Claudia Montenegro, Sara Moccia
{"title":"Deep learning in endoscopy: the importance of standardisation.","authors":"Alberto Paderno, Francesca Pia Villani, Alessandra Sordi, Claudia Montenegro, Sara Moccia","doi":"10.14639/0392-100X-N2580","DOIUrl":"10.14639/0392-100X-N2580","url":null,"abstract":"","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"430-432"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Laxague, Tommaso Gualtieri, Gary Brahm, John Yoo, S Danielle MacNeil, Kevin Fung, Adrian Mendez, Axel Sahovaler, Anthony C Nichols
{"title":"Ultrasound-guided wire localisation: a GPS for hidden head and neck tumours? A case series.","authors":"Francisco Laxague, Tommaso Gualtieri, Gary Brahm, John Yoo, S Danielle MacNeil, Kevin Fung, Adrian Mendez, Axel Sahovaler, Anthony C Nichols","doi":"10.14639/0392-100X-N2280","DOIUrl":"10.14639/0392-100X-N2280","url":null,"abstract":"<p><strong>Objectives: </strong>Ultrasound-guided wire (USGW) localisation for small non-palpable tumours before a revision head and neck surgery is an attractive pre-operative option to facilitate tumour identification and decrease potential complications. We describe five cases of pre-operative USGW localisation of non-palpable head and neck lesions to facilitate surgical localisation and resection.</p><p><strong>Methods: </strong>All patients undergoing pre-operative USGW localisation for non-palpable tumours of the head and neck region at London Health and Sciences Center, London, Ontario, Canada, were included. All the USGW localisations were performed by the same interventional radiologist, and the surgeries were performed by fellowship trained head and neck surgeons.</p><p><strong>Results: </strong>Five patients were included. All patients were undergoing revision surgery for recurrent or persistent disease. All successfully underwent a pre-operative USGW localisation of the non-palpable lesion before revision surgery. All lesions were localised intra-operatively with no peri-operative complications.</p><p><strong>Conclusions: </strong>USGW localisation is a safe and effective pre-operative technique for the identification of small non-palpable head and neck tumours.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"375-381"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria de Lourdes Rabelo Guimarães, Pedro Guimarães de Azevedo, Renan Pedra Souza, Bianca Gomes-Fernandes, Eitan Friedman, Luiz De Marco, Luciana Bastos-Rodrigues
{"title":"Evaluation of clinical and genetic factors in obstructive sleep apnoea.","authors":"Maria de Lourdes Rabelo Guimarães, Pedro Guimarães de Azevedo, Renan Pedra Souza, Bianca Gomes-Fernandes, Eitan Friedman, Luiz De Marco, Luciana Bastos-Rodrigues","doi":"10.14639/0392-100X-N2532","DOIUrl":"10.14639/0392-100X-N2532","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the correlation between several presumed candidate genes for obstructive sleep apnoea (OSA) and clinical OSA phenotypes and propose a predictive comprehensive model for diagnosis of OSA.</p><p><strong>Methods: </strong>This case-control study compared polysomnographic patterns, clinical data, morbidities, dental factors and genetic data for polymorphisms in <i>PER3, BDNF, NRXN3, APOE, HCRTR2, MC4R</i> between confirmed OSA cases and ethnically matched clinically unaffected controls. A logistic regression model was developed to predict OSA using the combined data.</p><p><strong>Results: </strong>The cohort consisted of 161 OSA cases and 81 controls. Mean age of cases was 53.5 ± 14.0 years, mostly males (57%) and mean body mass index (BMI) of 27.5 ± 4.3 kg/m<sup>2</sup>. None of the genotyped markers showed a statistically significant association with OSA after adjusting for age and BMI. A predictive algorithm included the variables gender, age, snoring, hypertension, mouth breathing and number of T alleles of <i>PER3 (rs228729)</i> presenting 76.5% specificity and 71.6% sensitivity.</p><p><strong>Conclusions: </strong>No genetic variant tested showed a statistically significant association with OSA phenotype. Logistic regression analysis resulted in a predictive model for diagnosing OSA that, if validated by larger prospective studies, could be applied clinically to allow risk stratification for OSA.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"409-416"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemicricoidectomy with modified rotational thyro-crico-tracheal anastomosis: a newborn in the family of crico-tracheal resection and anastomosis techniques.","authors":"Cesare Piazza, Davide Lancini, Gabriele Zigliani, Francesca Del Bon, Michele Tomasoni, Claudia Montenegro, Vittorio Rampinelli, Davide Mattavelli","doi":"10.14639/0392-100X-N2623","DOIUrl":"10.14639/0392-100X-N2623","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the present study is to describe our novel surgical technique of hemicricoidectomy and reconstruction with modified rotational thyro-crico-tracheal anastomosis for the treatment of non-squamous cell subglottic tumours. The procedure has been defined as Type E crico-tracheal resection and anastomosis (CTRA) following the University of Brescia (C)TRA classification introduced elsewhere.</p><p><strong>Methods: </strong>A detailed anatomical step-by-step dissection was reproduced and illustrated on a cadaveric laryngo-tracheal specimen. Moreover, oncological and functional outcomes of the first 5 patients who underwent Type E CTRA at our Institution between October 2016 and September 2022 are described.</p><p><strong>Results: </strong>Three patients underwent Type E CTRA for cricoid chondrosarcoma (CS) and 2 patients for subglottic adenoid cystic carcinoma (ACC). No post-operative complication was reported. All patients maintained intact oral intake and an intelligible voice at discharge. All but one patient with obstructive sleep apnoea hypopnea syndrome and lung comorbidity were successfully decannulated before discharge. At the last follow-up (April 2023), one patient experienced local recurrence of CS that was still amenable to conservative treatment by transoral debulking, while the remaining patients were free of disease.</p><p><strong>Conclusions: </strong>With the proper indications, Type E CTRA is a feasible and effective conservative surgical technique for selected non-squamous cell subglottic tumours.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"382-389"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eleonora M C Trecca, Michele Gaffuri, Giulia Molinari, Francesca Yoshie Russo, Mario Turri-Zanoni, Andrea Albera, Antonella Miriam di Lullo, Gennaro Russo, Giuditta Mannelli, Massimo Ralli
{"title":"Impact of the COVID-19 pandemic on paediatric otolaryngology: a nationwide study.","authors":"Eleonora M C Trecca, Michele Gaffuri, Giulia Molinari, Francesca Yoshie Russo, Mario Turri-Zanoni, Andrea Albera, Antonella Miriam di Lullo, Gennaro Russo, Giuditta Mannelli, Massimo Ralli","doi":"10.14639/0392-100X-N2452","DOIUrl":"10.14639/0392-100X-N2452","url":null,"abstract":"<p><strong>Objective: </strong>The COVID-19 pandemic profoundly modified the work routine in healthcare; however, its impact on the field of paediatric otorhinolaryngology (ORL) has been rarely investigated. The aim of this study was to assess the impact of COVID-19 on paediatric ORL.</p><p><strong>Methods: </strong>A questionnaire was developed by the Young Otolaryngologists of the Italian Society of ORL-Head and Neck Surgery (GOS). The questionnaire consisted of 26 questions related to workplace and personal paediatric ORL activities. The link was advertised on the official social media platforms and sent by e-mail to 469 Italian otolaryngologists.</p><p><strong>Results: </strong>The questionnaire was completed by 118 responders. During the pandemic, the main reduction was observed for surgical activity (78.8%), followed by outpatient service (16.9%). The conditions that were mostly impacted by a delayed diagnosis were respiratory infections in 45.8% of cases and sensorineural hearing loss in 37.3% of cases.</p><p><strong>Conclusions: </strong>Paediatric ORL was highly impacted by the COVID-19 pandemic, with a significant reduction of surgical and outpatient activities and a delay in time-sensitive diagnosis. Therefore, the implementation of new strategies, such as telemedicine, is recommended.</p>","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"352-359"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/6c/aoi-2023-05-352.PMC10551727.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Federico Russo, Marco Valentini, Camilla Czaczkes, Giorgio Sileo, Paolo Battaglia, Mario Turri-Zanoni, Apostolos Karligkiotis, Paolo Castelnuovo
{"title":"Pedicled nasal flaps in transnasal endoscopic surgery: review of indications and surgical techniques.","authors":"Federico Russo, Marco Valentini, Camilla Czaczkes, Giorgio Sileo, Paolo Battaglia, Mario Turri-Zanoni, Apostolos Karligkiotis, Paolo Castelnuovo","doi":"10.14639/0392-100X-N2469","DOIUrl":"10.14639/0392-100X-N2469","url":null,"abstract":"SUMMARY At present an exclusive endoscopic endonasal approach is sufficient in the majority of cases to treat pathologies involving the sinonasal compartment and the surrounding anatomical subsites (e.g. orbit, ventral skull base, upper parapharyngeal space, etc.) with the advantage of minimising surgical invasiveness. In this context, nasal vascularised local flaps are widely employed because they represent a more effective option for reconstruction or preservation of noble/vital structures compared to grafts. On the other hand, the surgical extension and morbidity are minimised compared to regional or free flaps. Several nasal local flaps have been described in the literature: the aim of this review is to examine their applications, characteristics, indications, success rates and morbidities. Different nasal flaps based on single or multiple pedicles have been described; the choice between them is based on different factors such as the flap’s shape and dimension, localisation of the pedicle’s origin, width of rotation angle, previous surgeries which could compromise vascularisation, and surgical experience, in addition to the position and dimension of the area which must be resurfaced.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"297-309"},"PeriodicalIF":2.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/48/aoi-2023-05-297.PMC10551732.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9519008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}