Acta Otorhinolaryngologica Italica最新文献_第3页

Factors influencing audiologic outcomes in ossiculoplasty for chronic otitis media: a prospective multicentre study. 影响慢性中耳炎听骨成形术听力学结果的因素：一项前瞻性多中心研究。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-12-01 DOI: 10.14639/0392-100X-N2973

Gianluca Fadda, Federico Merlino, Giovanni Cavallo, Simone Moglio, Giuseppe Magliulo, Giannicola Iannella, Antonio Greco, Annalisa Pace, Andrea De Vito, Giovanni Cammaroto, Salvatore Ronsivalle, Milena Di Luca, Federica Parisi, Antonio Frisina, Pietro Canzi, Salvatore Ferlito, Antonino Maniaci

{"title":"Factors influencing audiologic outcomes in ossiculoplasty for chronic otitis media: a prospective multicentre study.","authors":"Gianluca Fadda, Federico Merlino, Giovanni Cavallo, Simone Moglio, Giuseppe Magliulo, Giannicola Iannella, Antonio Greco, Annalisa Pace, Andrea De Vito, Giovanni Cammaroto, Salvatore Ronsivalle, Milena Di Luca, Federica Parisi, Antonio Frisina, Pietro Canzi, Salvatore Ferlito, Antonino Maniaci","doi":"10.14639/0392-100X-N2973","DOIUrl":"https://doi.org/10.14639/0392-100X-N2973","url":null,"abstract":"Objectives: Chronic otitis media (COM) is a prevalent condition affecting auditory function. Ossiculoplasty is a known treatment strategy, but its effectiveness concerning the presence of cholesteatoma has not been extensively studied.Methods: We conducted a multicentre study involving 153 patients diagnosed with COM without cholesteatoma (ncCOM) and with cholesteatoma (cCOM). Patients underwent ossiculoplasty, and postoperative hearing outcomes were analysed.Results: After patient selection, 133 participants were included. Postoperatively, significant improvements in hearing function were observed in both groups, substantiating the role of ossiculoplasty in treatment of COM. However, different outcomes were noted between ncCOM and cCOM. Patients with cCOM demonstrated a slightly lesser degree of hearing improvement post-surgery compared to their ncCOM counterparts.Conclusions: Our findings confirm ossiculoplasty as a standard and effective treatment strategy for COM. The presence of cholesteatoma may influence the effectiveness of surgery, underscoring the need for individualised surgical planning. Future research should focus on confirming these results and more comprehensively exploring the impact of cholesteatoma on surgical outcomes.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 6","pages":"400-411"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lateral hypopharyngectomy with laryngeal preservation reconstructed with inlay fascio-cutaneous free flaps: clinical and functional outcomes. 用镶嵌式筋膜-皮肤游离瓣重建保留喉部的侧下咽切除术：临床和功能效果。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-12-01 Epub Date: 2024-09-15 DOI: 10.14639/0392-100X-N3071

Davide Lancini, Claudia Montenegro, Davide Mattavelli, Alberto Grammatica, Vittorio Rampinelli, Gabriele Zigliani, Cesare Piazza

{"title":"Lateral hypopharyngectomy with laryngeal preservation reconstructed with inlay fascio-cutaneous free flaps: clinical and functional outcomes.","authors":"Davide Lancini, Claudia Montenegro, Davide Mattavelli, Alberto Grammatica, Vittorio Rampinelli, Gabriele Zigliani, Cesare Piazza","doi":"10.14639/0392-100X-N3071","DOIUrl":"10.14639/0392-100X-N3071","url":null,"abstract":"Objective: Lateral hypopharyngectomy (LH) is one of the organ-preservation surgical strategies available for treatment of selected naïve early squamous cell carcinoma (SCC), as well as for rarer non-SCC tumours and persistent/recurrent/second primaries after chemoradiation of the lateral wall of the piriform sinus. Its reconstructive methods have been the subject of different approaches without a general consensus. The aim of the present study is to describe a retrospective series of LH reconstructed by inlay fascio-cutaneous free flaps, reporting on oncological and functional outcomes.Methods: Patients who underwent LH at the Department of Otorhinolaryngology - Head and Neck Surgery of the University of Brescia, Italy, between 2017 and 2023 were retrospectively reviewed. Clinical history, tumour histotype, postoperative complications, functional, and oncological outcomes were collected.Results: Seven patients (6 males, 1 female) were included. In all, 29% had a treatment-naïve neoplasm, while 71% had recurrent disease. The final histology included 3 SCC, 2 synovial sarcomas, one liposarcoma, and one single-site mucosal metastasis from cutaneous melanoma. Negative margins were achieved in 6 patients (86%). All patients had swallowing rehabilitation by speech therapists and were able to safely eat a free diet at discharge, except for one who needed a percutaneous endoscopic gastrostomy to support nutritional oral intake. After a mean follow-up of 34.3 months, all patients except one are alive.Conclusions: Our study showed that, in selected cases, it is possible to radically remove lateral hypopharyngeal tumours with laryngeal preservation and free flaps inlay reconstruction, with a low rate of complications and acceptable functional and oncological results.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":" ","pages":"361-367"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical update on endoscopic dacryocystorhinostomy. 内窥镜泪囊鼻腔造口术的重要进展。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-12-01 DOI: 10.14639/0392-100X-N2916

Luca Giovanni Locatello, Enrico Redolfi De Zan, Nicole Caiazza, Anna Tarantini, Paolo Lanzetta, Cesare Miani

{"title":"A critical update on endoscopic dacryocystorhinostomy.","authors":"Luca Giovanni Locatello, Enrico Redolfi De Zan, Nicole Caiazza, Anna Tarantini, Paolo Lanzetta, Cesare Miani","doi":"10.14639/0392-100X-N2916","DOIUrl":"https://doi.org/10.14639/0392-100X-N2916","url":null,"abstract":"Objectives: Endoscopic dacryocystorhinostomy (endo-DCR) is becoming a workhorse in the management of distal lacrimal duct obstruction. It yields success rates comparable to external DCR, with the advantage of no external scars. However, it requires multidisciplinary expertise and many uncertainties in terms of proper indications, technique, and perioperative management still exist.Methods: Systematic review of the literature in the last 5 years using PubMed and Google Scholar.Results: A total of 66 articles were included. Many technical modifications and surgical refinements have been proposed, but a formal comparison of the various techniques is hampered by methodological heterogeneity. The use of local anaesthesia and perioperative adjunctive techniques to reduce the risk of restenosis are also gaining popularity even if the level of evidence remains weak.Conclusions: Endo-DCR offers satisfactory clinical outcomes even though there are many grey areas that need to be addressed in future high-quality studies.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 6","pages":"351-360"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of the Italian digit-in-noise test. 意大利数字噪声测试的开发和验证。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-12-01 DOI: 10.14639/0392-100X-N3064

Pasquale Viola, Alessia Astorina, Antonio Mancuso, Giorgio Presti, Alfonso Scarpa, Carlo Baruffini, Giuseppe Chiarella

{"title":"Development and validation of the Italian digit-in-noise test.","authors":"Pasquale Viola, Alessia Astorina, Antonio Mancuso, Giorgio Presti, Alfonso Scarpa, Carlo Baruffini, Giuseppe Chiarella","doi":"10.14639/0392-100X-N3064","DOIUrl":"https://doi.org/10.14639/0392-100X-N3064","url":null,"abstract":"Objectives: This research aims to validate the digits-in-noise (DIN) test for the Italian language and develop a version capable of independently assessing both ears while maintaining acceptable administration times.Methods: Individual digits from 0 to 9 in Italian were recorded and adjusted to equalise recognition probabilities. An iOS application (APP) was developed for the independent ear test using triplets in noise. The application incorporates a new proprietary adaptive procedure developed by Amplifon to minimise the number of steps required to determine the Speech Reception Threshold (SRT).Thirty-nine subjects were recruited for equalisation of digits, 45 normal-hearing and 62 with various degrees of hearing loss for normative-data assessment.Results: The results demonstrate the ability to determine a threshold value for normal hearing consistent with the existing literature and identify threshold values corresponding to the main World Health Organization hearing loss categories.Conclusions: A DIN test for the Italian language has been developed and validated to evaluate the SRT of each ear individually. The adaptive algorithm optimises the necessary steps while maintaining acceptable test duration for both ears. Users can autonomously conduct the test using a standard personal iOS device (tablet or smartphone).","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 6","pages":"392-399"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term safety and subjective satisfaction of Bonebridge and Vibrant Soundbridge in congenital unilateral conductive hearing loss. Bonebridge 和 Vibrant Soundbridge 治疗先天性单侧传导性听力损失的长期安全性和主观满意度。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N2659

Yujie Liu, Lin Yang, Yuan Wang, Jikai Zhu, Wenxi Qiu, Mengshuang Lv, Danni Wang, Shouqin Zhao

{"title":"Long-term safety and subjective satisfaction of Bonebridge and Vibrant Soundbridge in congenital unilateral conductive hearing loss.","authors":"Yujie Liu, Lin Yang, Yuan Wang, Jikai Zhu, Wenxi Qiu, Mengshuang Lv, Danni Wang, Shouqin Zhao","doi":"10.14639/0392-100X-N2659","DOIUrl":"10.14639/0392-100X-N2659","url":null,"abstract":"Purpose: The objective of this study was to assess and compare the long-term safety and subjective satisfaction levels of Bonebridge (BB) and Vibrant Soundbridge (VSB) in patients with congenital unilateral conductive hearing loss (UCHL).Methods: The hearing effectiveness was measured using sound field hearing threshold (SFHT) and word recognition score (WRS). Long-term safety and subjective satisfaction levels were measured by questionnaires, including Speech, Spatial, and Qualities of Hearing Scale-12 (SSQ-12) and Abbreviated Profile of Hearing Aid Benefit (APHAB).Results: Both BB and VSB were effective in improving the hearing of patients with congenital UCHL. Four of the 20 patients discontinued wearing the device postoperatively, and no complications were reported by long-term users. Patients experienced an overall improvement in their hearing experience across most subscales of SSQ-12 and a lower hearing problem rate across most subscales of the APHAB after implantation. However, the 'quality of hearing' subscale in the SSQ-12 did not show any improvement, and the aversiveness subscale in the APHAB exhibited a relatively higher percentage of reported problems after BB or VSB implantation. No significant differences were observed in SFHT, WRS, SSQ-12, and APHAB between the two groups.Conclusions: Both BB and VSB are effective in improving the hearing of UCHL patients, with high subjective satisfaction and low complication rates in the long-term postoperative period, with no significant difference between the two devices. Follow-up device fitting is essential, especially to address increased device sound or noise after surgery, reduce non-usage rates and achieve higher subjective satisfaction levels.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 5","pages":"322-332"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of intraoperative scoring system in rhino-orbital mucormycosis as a prognostic tool. 鼻眶粘液瘤病术中评分系统作为预后工具的实用性。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N2705

Neehal Zuturu, Vijendra S Shenoy, Sanchit Bajpai, Sreenivas Kamath Kasargod, Thripthi Rai, Sushmitha Kabekkodu, Kshithi K, Navya Parvathareddy

{"title":"Utility of intraoperative scoring system in rhino-orbital mucormycosis as a prognostic tool.","authors":"Neehal Zuturu, Vijendra S Shenoy, Sanchit Bajpai, Sreenivas Kamath Kasargod, Thripthi Rai, Sushmitha Kabekkodu, Kshithi K, Navya Parvathareddy","doi":"10.14639/0392-100X-N2705","DOIUrl":"10.14639/0392-100X-N2705","url":null,"abstract":"Objective: To assess the utility of an intraoperative scoring system for mucormycosis and to predict prognosis by comparing the score with postoperative outcomes.Methods: This study was conducted among 80 patients with mucormycosis who underwent surgical management with mandatory pterygopalatine fossa and infratemporal fossa exploration. All cases were scored using our intraoperative scoring assessment tool. Postoperative outcomes in terms of favourable prognosis and mortality were evaluated and compared with demographics, clinical history and intraoperative findings.Results: An intraoperative score of more than 25 was statistically significant in predicting mortality (p < 0.0001). In all, 86.7% of patients with a score above 25 succumbed to the disease. Statistical significance of mortality (p < 0.05) was observed in those with involvement of pterygopalatine fossa (78.9%), orbit (73.7%), infratemporal fossa (57.9%), cribriform plate (36.8%) and those with history of intake of antiviral drugs (47.4%), use of supplemental oxygen (31.6%) and renal failure (26.3%).Conclusions: This study enabled better prediction of postoperative prognosis in mucormycosis and reiterated the importance of exploration of pterygopalatine fossa and infratemporal fossa in management and prognostication of invasive fungal sinusitis.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 5","pages":"313-321"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of PET/CT in improving the cost effectiveness of nimotuzumab in nasopharyngeal carcinoma. PET/CT 在提高尼莫妥珠单抗治疗鼻咽癌的成本效益方面的作用。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N2827

Xiao-Bin Fu, Ting-Ting Li, Zhao-Dong Fei, Chuan-Ben Chen

{"title":"Role of PET/CT in improving the cost effectiveness of nimotuzumab in nasopharyngeal carcinoma.","authors":"Xiao-Bin Fu, Ting-Ting Li, Zhao-Dong Fei, Chuan-Ben Chen","doi":"10.14639/0392-100X-N2827","DOIUrl":"10.14639/0392-100X-N2827","url":null,"abstract":"Objective: This study aims to use the maximum standardised uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography to improve the cost effectiveness of nimotuzumab (NTZ) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC).Methods: Two hundred and forty-eigh patients with LA-NPC, who met the inclusion criteria, were recruited from January 2012 to June 2019. The survival differences and independent factors were assessed using the Kaplan-Meier method and by Cox proportional hazards regression analysis. A cost effectiveness analysis was performed.Results: The optimal cut-off value for SUVmax was 12.92. Multivariable analysis indicated a prognostic significance of overall survival (OS) for the NTZ treatment (p = 0.023) and SUVmax (p = 0.014). The exploratory subgroup survival analysis revealed that LA-NPC patients with SUVmax > 12.92 treated with concurrent chemoradiotherapy (CCRT) and NTZ had a significantly improved 3-year OS compared to patients treated with CCRT alone (96.2 vs 73.2%, p = 0.047). Furthermore, the treatment cost for NTZ was $6,317.61. This incurred an additional cost of $274.68 for every 1% increase in OS.Conclusions: For patients with LA-NPC with SUVmax > 12.92, the addition of NTZ to CCRT can improve OS and is cost effective.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 5","pages":"296-305"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laryngopharyngeal reflux: knowledge, attitudes, and practices among primary healthcare physicians. 喉咽反流：初级保健医生的知识、态度和做法。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N2776

Sultan Bin Obaid, Shahad Bin Obaid, Mohammed Mesfer Alessa, Mohammed Alnajeim, Rakan Almetary, Khalid H Malki, Tamer Mesallam, Daniele Farneti, Mohamed Farahat

{"title":"Laryngopharyngeal reflux: knowledge, attitudes, and practices among primary healthcare physicians.","authors":"Sultan Bin Obaid, Shahad Bin Obaid, Mohammed Mesfer Alessa, Mohammed Alnajeim, Rakan Almetary, Khalid H Malki, Tamer Mesallam, Daniele Farneti, Mohamed Farahat","doi":"10.14639/0392-100X-N2776","DOIUrl":"10.14639/0392-100X-N2776","url":null,"abstract":"Objective: The aim of this study was to estimate the level of knowledge, attitudes, and practices regarding laryngopharyngeal reflux (LPR) among primary healthcare (PHC) physicians in Saudi Arabia.Methods: This quantitative cross-sectional study used an online-based questionnaire distributed to physicians in PHC facilities and hospitals in Saudi Arabia. The questionnaire consisted of four sections that provided data on demographics, knowledge, attitudes, and practices.Results: Of the 473 physicians included in the study, one-third were unaware of LPR, and two-thirds were unfamiliar with the reflux symptom index (RSI). The most common sources of LPR knowledge were textbooks and literature (49.8%). The most recognised risk factor, symptom, and complication were high body mass index (75.8%), voice problems (82.4%), and laryngeal cancer (70.6%), respectively. The most recognised diagnostic and treatment options were laryngoscopy (73.5%) and lifestyle modifications (87.3%), respectively, while only 60.4% of participants recognised proton pump inhibitors as a treatment option. Most PHC physicians believed that LPR is underdiagnosed and that primary prevention and awareness among the general population need to be improved.Conclusions: One in three PHC physicians knew nothing about LPR, and two in three were unfamiliar with the RSI. More than half could not recognise all major symptoms of LPR, which might be a cause for concern, as recognising these symptoms is crucial for proper diagnosis. We recommend increasing the education of physicians about LPR, its signs and symptoms, and the RSI, all of which provide valuable clues for diagnosis.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 5","pages":"306-312"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prognostic role of salivary miRNAs in oral squamous cell carcinoma: technical challenges and clinical perspectives. 唾液 miRNA 在口腔鳞状细胞癌中的预后作用：技术挑战与临床视角。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 Epub Date: 2024-09-15 DOI: 10.14639/0392-100X-N2981

Chiara Romani, Claudia Assoni, Davide Mattavelli, Vittorio Rampinelli, Cesare Piazza

引用次数: 0

Up-regulation of HIF-1α in refractory sudden sensorineural hearing loss. 难治性突发性感音神经性听力损失中 HIF-1α 的上调。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N3017

Wandong She, Ziwen Gao, Wenyan Zhu, Mingfeng Guan, Jie Hou, Xiaorui Chen, Wei Ma

{"title":"Up-regulation of HIF-1α in refractory sudden sensorineural hearing loss.","authors":"Wandong She, Ziwen Gao, Wenyan Zhu, Mingfeng Guan, Jie Hou, Xiaorui Chen, Wei Ma","doi":"10.14639/0392-100X-N3017","DOIUrl":"10.14639/0392-100X-N3017","url":null,"abstract":"Objectives: To investigate the expression of hypoxia-inducible factor-1α (HIF-1α) in patients with refractory sudden sensorineural hearing loss (SSNHL).Material and methods: Thirty patients with refractory SSNHL were treated with intratympanic methylprednisolone perfusion (IMP) for 10 days. Expression of HIF-1α and histone deacetylase 2 (HDAC2) was evaluated in peripheral blood mononuclear cells (PBMCs) and in vitro.Results: Significant hearing improvement (≥ 15 dB) was observed in 16 patients [IMP glucocorticoid sensitive (GCS) group], while 14 patients had no therapeautic hearing recovery [IMP GC resistance (GCR) group]. The expression of HDAC2 decreased and HIF-1a increased in all refractory SSNHL patients before IMP. The expression of HDAC2 and HIF-1α after IMP was significantly changed in the GCS group, but not in the GCR group. The same expression profile was also observed in House Ear Institute-organ of Corti-1 (HEI-OC1) cells exposed to oxidative stress (OS). The results of gene manipulation experiments indicate that HIF-1α up-regulation significantly reduced HDAC2 expression in HEI-OC1 cells, especially under conditions of OS.Conclusions: This study suggests that HIF-1α activation inhibits HDAC2 expression, causing glucocorticoid resistance in refractory SSNHL. HIF-1α might serve as a potential biomarker to predict prognosis of refractory SSNHL.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 5","pages":"333-341"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0