Acta Otorhinolaryngologica Italica最新文献_第3页

Laryngopharyngeal reflux: knowledge, attitudes, and practices among primary healthcare physicians. 喉咽反流：初级保健医生的知识、态度和做法。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N2776

Sultan Bin Obaid, Shahad Bin Obaid, Mohammed Mesfer Alessa, Mohammed Alnajeim, Rakan Almetary, Khalid H Malki, Tamer Mesallam, Daniele Farneti, Mohamed Farahat

{"title":"Laryngopharyngeal reflux: knowledge, attitudes, and practices among primary healthcare physicians.","authors":"Sultan Bin Obaid, Shahad Bin Obaid, Mohammed Mesfer Alessa, Mohammed Alnajeim, Rakan Almetary, Khalid H Malki, Tamer Mesallam, Daniele Farneti, Mohamed Farahat","doi":"10.14639/0392-100X-N2776","DOIUrl":"10.14639/0392-100X-N2776","url":null,"abstract":"Objective: The aim of this study was to estimate the level of knowledge, attitudes, and practices regarding laryngopharyngeal reflux (LPR) among primary healthcare (PHC) physicians in Saudi Arabia.Methods: This quantitative cross-sectional study used an online-based questionnaire distributed to physicians in PHC facilities and hospitals in Saudi Arabia. The questionnaire consisted of four sections that provided data on demographics, knowledge, attitudes, and practices.Results: Of the 473 physicians included in the study, one-third were unaware of LPR, and two-thirds were unfamiliar with the reflux symptom index (RSI). The most common sources of LPR knowledge were textbooks and literature (49.8%). The most recognised risk factor, symptom, and complication were high body mass index (75.8%), voice problems (82.4%), and laryngeal cancer (70.6%), respectively. The most recognised diagnostic and treatment options were laryngoscopy (73.5%) and lifestyle modifications (87.3%), respectively, while only 60.4% of participants recognised proton pump inhibitors as a treatment option. Most PHC physicians believed that LPR is underdiagnosed and that primary prevention and awareness among the general population need to be improved.Conclusions: One in three PHC physicians knew nothing about LPR, and two in three were unfamiliar with the RSI. More than half could not recognise all major symptoms of LPR, which might be a cause for concern, as recognising these symptoms is crucial for proper diagnosis. We recommend increasing the education of physicians about LPR, its signs and symptoms, and the RSI, all of which provide valuable clues for diagnosis.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 5","pages":"306-312"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prognostic role of salivary miRNAs in oral squamous cell carcinoma: technical challenges and clinical perspectives. 唾液 miRNA 在口腔鳞状细胞癌中的预后作用：技术挑战与临床视角。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 Epub Date: 2024-09-15 DOI: 10.14639/0392-100X-N2981

Chiara Romani, Claudia Assoni, Davide Mattavelli, Vittorio Rampinelli, Cesare Piazza

引用次数: 0

Up-regulation of HIF-1α in refractory sudden sensorineural hearing loss. 难治性突发性感音神经性听力损失中 HIF-1α 的上调。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N3017

Wandong She, Ziwen Gao, Wenyan Zhu, Mingfeng Guan, Jie Hou, Xiaorui Chen, Wei Ma

{"title":"Up-regulation of HIF-1α in refractory sudden sensorineural hearing loss.","authors":"Wandong She, Ziwen Gao, Wenyan Zhu, Mingfeng Guan, Jie Hou, Xiaorui Chen, Wei Ma","doi":"10.14639/0392-100X-N3017","DOIUrl":"10.14639/0392-100X-N3017","url":null,"abstract":"Objectives: To investigate the expression of hypoxia-inducible factor-1α (HIF-1α) in patients with refractory sudden sensorineural hearing loss (SSNHL).Material and methods: Thirty patients with refractory SSNHL were treated with intratympanic methylprednisolone perfusion (IMP) for 10 days. Expression of HIF-1α and histone deacetylase 2 (HDAC2) was evaluated in peripheral blood mononuclear cells (PBMCs) and in vitro.Results: Significant hearing improvement (≥ 15 dB) was observed in 16 patients [IMP glucocorticoid sensitive (GCS) group], while 14 patients had no therapeautic hearing recovery [IMP GC resistance (GCR) group]. The expression of HDAC2 decreased and HIF-1a increased in all refractory SSNHL patients before IMP. The expression of HDAC2 and HIF-1α after IMP was significantly changed in the GCS group, but not in the GCR group. The same expression profile was also observed in House Ear Institute-organ of Corti-1 (HEI-OC1) cells exposed to oxidative stress (OS). The results of gene manipulation experiments indicate that HIF-1α up-regulation significantly reduced HDAC2 expression in HEI-OC1 cells, especially under conditions of OS.Conclusions: This study suggests that HIF-1α activation inhibits HDAC2 expression, causing glucocorticoid resistance in refractory SSNHL. HIF-1α might serve as a potential biomarker to predict prognosis of refractory SSNHL.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 5","pages":"333-341"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modular anatomic approach to oral tongue carcinoma: functional outcomes and quality of life. 口腔舌癌的模块化解剖方法：功能结果和生活质量。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N3041

Luca Gazzini, Virginia Dallari, Arianna Caselli, Fabio Vittadello, Luca Calabrese

{"title":"Modular anatomic approach to oral tongue carcinoma: functional outcomes and quality of life.","authors":"Luca Gazzini, Virginia Dallari, Arianna Caselli, Fabio Vittadello, Luca Calabrese","doi":"10.14639/0392-100X-N3041","DOIUrl":"10.14639/0392-100X-N3041","url":null,"abstract":"Objectives: The purpose of this study is to present the long-term functional swallowing outcomes of various surgical approaches to oral tongue/floor of mouth squamous cell carcinoma (OTFOMSCC) according to a modular and compartment-based concept previously described elsewhere.Methods: A retrospective study was conducted on patients undergoing surgery for OTFOMSCC from January 2017 to April 2023 in the Department of Otorhinolaryngology at the Hospital of Bolzano. Functional swallowing outcomes and quality of life (QoL) were assessed through the administration of a scale and questionnaires between 6 months and 1 year postoperatively or after the end of adjuvant therapy, stratifying the results according to the surgical technique used.Results: A total of 92 patients with OTFOMSCC were enrolled: 44 patients underwent transoral anatomically guided surgery (TAGS) for early-stage tumours, and 48 underwent major surgery for advanced stages. Among the latter 48 patients: 35 underwent compartment tongue surgery (CTS), 3 underwent extended glossectomies (EG) Type A, 6 underwent EG Type B, and 4 underwent EG Type C. After TAGS, all patients resumed oral feeding for all consistencies. In the CTS group, only one patient faced challenges with pure liquids, yet all achieved the target of consuming a semisolid and semiliquid diet. EG exhibited a noticeable decline in performance from Type A to total glossectomy (Type C).Conclusions: Following an anatomically-guided approach to the resection of OTFOMSCC allows the surgery to be modulated on the structures involved by the tumour, thus achieving optimal oncological results, while maintaining the possibility to predict functional outcomes and postoperative QoL.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 5","pages":"285-295"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telemedicine for hearing-impaired patients in Italy. 意大利听力受损病人的远程医疗。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-10-01 DOI: 10.14639/0392-100X-N3116

Sara Ghiselli, Flavia Sorrentino, Francesco Lazzerini, Chiara Rabito, Alessandra Murri, Pietro Scimemi

引用次数: 0

Recurrent respiratory papillomatosis: comparing in-office and operating room treatments. 复发性呼吸道乳头状瘤病：诊室治疗与手术室治疗的比较。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-08-01 DOI: 10.14639/0392-100X-N2951

Marta Filauro, Alberto Vallin, Claudio Sampieri, Pietro Benzi, Giulia Gabella, Marta De Vecchi, Alessandro Ioppi, Francesco Mora, Giorgio Peretti

{"title":"Recurrent respiratory papillomatosis: comparing in-office and operating room treatments.","authors":"Marta Filauro, Alberto Vallin, Claudio Sampieri, Pietro Benzi, Giulia Gabella, Marta De Vecchi, Alessandro Ioppi, Francesco Mora, Giorgio Peretti","doi":"10.14639/0392-100X-N2951","DOIUrl":"10.14639/0392-100X-N2951","url":null,"abstract":"Objective: We report the management of recurrent respiratory papillomatosis (RRP) employing a protocol that includes both office-based (OB) and general anaesthesia (GA) procedures. Quality of life (QoL) outcomes in the OB cohort were compared to those obtained from an historical cohort treated only under GA.Methods: Patients affected by RRP from 2019 until 2023 (\"new protocol\") and from 2012 to 2019 (\"historical protocol\") were enrolled. In both groups the Derkay site score (DSS) was calculated. In patients adhering to the new protocol, questionnaires measuring QoL were prospectively administered (voice handicap hindex-10 [VHI-10] along with a specific questionnaire to measure the tolerance to the OB procedures). A cost analysis was also performed.Results: In all, 35 patients composed the new protocol cohort and 13 the historical. In the first group, patients underwent a median of 4 treatments. At 2 years, 68% of patients were treated exclusively in the office. Overall, for the new protocol, median DSS and VHI-10 after one year were both significantly lower than those at baseline [2 vs 4 and 3 vs 14, respectively; p < 0.001]. No differences were found between the new and the historical protocol cohorts considering DSS over time.Conclusions: Treatment of RRP may be conducted successfully in an office-based setting reducing healthcare costs.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 4","pages":"233-241"},"PeriodicalIF":2.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TIM-3-driven macrophage polarisation is associated to recalcitrant chronic rhinosinusitis with nasal polyps. TIM-3 驱动的巨噬细胞极化与伴有鼻息肉的顽固性慢性鼻炎有关。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-08-01 DOI: 10.14639/0392-100X-N2717

Tao Jiang, Tao Yu, Lu Jiang, Zongjing Tong

{"title":"TIM-3-driven macrophage polarisation is associated to recalcitrant chronic rhinosinusitis with nasal polyps.","authors":"Tao Jiang, Tao Yu, Lu Jiang, Zongjing Tong","doi":"10.14639/0392-100X-N2717","DOIUrl":"10.14639/0392-100X-N2717","url":null,"abstract":"Objective: This study evaluated the expression of TIM-3 and its influence on macrophage polarisation in recalcitrant chronic rhinosinusitis with nasal polyps (CRSwNP).Methods: We detected TIM-3 expression in serum and tissue samples of healthy controls (HC), primary CRSwNP, and patients with recurrent CRSwNP. Macrophage markers were detected among three groups, and their correlations with TIM-3 levels were examined. Macrophages from circulating blood were collected and used to examine the impact of TIM-3 on polarisation in vitro.Results: TIM-3 levels were enhanced in the CRSwNP group compared to the HC group. Tissue immunofluorescence revealed elevated TIM-3 expression in patients with CRSwNP, and patients with multiple recurrences exhibited higher TIM-3 levels compared to their first recurrence and baseline levels. Tissue CD163 and CD206 levels were higher in recurrent CRSwNP in comparison with primary cases and HCs, and had a positive correlation with TIM-3 levels. TIM-3 overexpression promoted M2 polarisation and enhanced TGF-β1 and IL-10 secretion.Conclusions: TIM-3 expression was enhanced in patients with CRSwNP, especially in those undergoing revision surgeries. TIM-3 may be a novel biomarker for recalcitrant CRSwNP. TIM-3-driven M2 polarisation might be involved in the mechanisms of recurrent CRSwNP.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 4","pages":"242-251"},"PeriodicalIF":2.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of frontal sinus and frontal recess inverted papilloma: our experience and systematic review. 额窦和额凹倒置乳头状瘤的治疗：我们的经验和系统回顾。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-08-01 DOI: 10.14639/0392-100X-N2331

Piergiorgio Gaudioso, Alessandro Vinciguerra, Benjamin Verillaud, Philippe Herman

{"title":"Management of frontal sinus and frontal recess inverted papilloma: our experience and systematic review.","authors":"Piergiorgio Gaudioso, Alessandro Vinciguerra, Benjamin Verillaud, Philippe Herman","doi":"10.14639/0392-100X-N2331","DOIUrl":"10.14639/0392-100X-N2331","url":null,"abstract":"Objective: For frontal sinus inverted papilloma (FSIP) management, an endoscopic endonasal approach (EEA) can be combined (or not) with an external approach by an osteoplastic flap (OPF) or with a more conservative open approach. The present study aims to describe our experience in the management of FSIP, focusing on disease-related and anatomical features influencing outcomes and recurrence.Methods: This case series of FSIP investigated anatomical and disease-related predictors of recurrence associated with EEA or a combined EEA-OPF approach. A systematic review was also performed, selecting publications on IP with the insertion point in the frontal sinus or frontal recess.Results: Among 30 patients included, 18 underwent EEA, while 12 received a combined EEA-OPF approach. During a median follow-up of 37 months, the frontal sinus was cleared of IP in all cases except 2 in the EEA group, who presented a complex posterior wall shape of the frontal sinus. From the systematic review, a combined EEA-OPF approach was associated with a lower risk of recurrence.Conclusions: A correct indication for a combined EEA-OPF approach is paramount and should integrate all disease-related and anatomical features, including posterior wall shape.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 4","pages":"252-260"},"PeriodicalIF":2.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management and prognosis of iatrogenic perforations of the cervical oesophagus and hypopharynx. 颈食道和下咽部先天性穿孔的处理和预后。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-08-01 DOI: 10.14639/0392-100X-N2905

Einav G Levin, Amit Ritter, Amir Amitai, Thomas Shpitzer, Gideon Bachar, Aviram Mizrachi, Yaniv Hamzany

{"title":"Management and prognosis of iatrogenic perforations of the cervical oesophagus and hypopharynx.","authors":"Einav G Levin, Amit Ritter, Amir Amitai, Thomas Shpitzer, Gideon Bachar, Aviram Mizrachi, Yaniv Hamzany","doi":"10.14639/0392-100X-N2905","DOIUrl":"10.14639/0392-100X-N2905","url":null,"abstract":"Objective: The study aimed to identify factors affecting the management and prognosis of iatrogenic cervical oesophageal and hypopharyngeal perforations (iCEHPs).Methods: We retrospectively analysed 24 patients treated for iCEHP between 2004 and 2021 at a tertiary university medical centre. Data on demographics, clinical features, imaging, management and outcomes were collected. Factors associated with primary management and patient outcome were assessed.Results: The most common management approach was surgical neck exploration (15 patients, 62.5%). Surgical management was used in 93% of uncontained perforations compared to 11% of contained perforations (p < 0.001). Surgically-treated patients had higher levels of C-reactive protein (CRP) than conservatively-treated patients (median, 18.3 vs 4.8 mg/dL; p = 0.001). Delayed diagnosis (≥ 24 hours) was associated with increased mortality (100 vs 5%; p = 0.011). The mortality rate was significantly higher in patients who had a history of neck irradiation than in patients who did not (67 vs 5%; p = 0.032).Conclusions: Early diagnosis of iCEHP improves outcomes. The appropriate management should be carefully selected on the basis of CRP level and imaging findings. Prior neck radiation is a poor prognostic factor.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"44 4","pages":"214-222"},"PeriodicalIF":2.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of otoliquorrhoea secondary to immunotherapy response in head and neck cutaneous squamous cell carcinoma. When abrupt response may worry the physician. 头颈部皮肤鳞状细胞癌免疫治疗反应继发耳咽炎一例。突然的反应可能会让医生担心。

IF 2.1 4区医学

Acta Otorhinolaryngologica Italica Pub Date : 2024-08-01 Epub Date: 2023-10-10 DOI: 10.14639/0392-100X-N2647

Luigi Lorini, Michele Tomasoni, Paolo Rondi, Andrea Esposito, Marco Ravanelli, Alberto Schreiber, Antonio Biroli, Paolo Bossi

引用次数: 0