Acta Psychiatrica Scandinavica最新文献

{"title":"Impact of Obstetric Complications in Subjects at Clinical High Risk for Psychosis: A Systematic Review and Meta-Analysis","authors":"Inmaculada Baeza,&nbsp;Jordina Tor,&nbsp;Elena de la Serna,&nbsp;Gisela Sugranyes,&nbsp;Fàtima Crispi,&nbsp;Montserrat Izquierdo-Renau,&nbsp;Marta del Olmo,&nbsp;Montserrat Dolz,&nbsp;Clemente García-Rizo","doi":"10.1111/acps.13816","DOIUrl":"https://doi.org/10.1111/acps.13816","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Exposure to obstetric complications (OCs) increases the risk of developing psychosis and schizophrenia in offspring. However, studies with subjects at clinical high risk for psychosis (CHR) have reported inconsistent results. We conducted a systematic review and meta-analysis to evaluate the prevalence of OCs among CHR subjects and controls and examine their impact on the transition to psychosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Four databases (Web of Science, PubMed, Latindex, and Dialnet) were systematically searched for articles published between 1995 and June 6, 2024. The risk of bias was assessed using the Newcastle–Ottawa scale. Articles providing data on OCs in CHR subjects were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 6037 records were retrieved through systematic and citation searches. Nine articles met the inclusion criteria for our systematic review and provided data for meta-analysis. A total of 555 CHR participants were included. Meta-analysis showed a significantly higher prevalence of OCs in CHR subjects versus controls: RR = 1.45 (95% CI: 1.16, 1.81), (<i>Z</i> = 3.27, <i>p</i> = 0.0011). Data from three longitudinal studies assessed transition to psychosis and our meta-analysis found a trend toward an increased risk of transition in CHR subjects with a history of OCs compared to others: RR = 2.05 (95% CI: 0.98, 4.26), <i>Z</i> = 1.91, <i>p</i> = 0.056.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CHR for psychosis was associated with OCs, though their role in the transition to psychosis requires further study. OCs should be recorded and analyzed in CHR individuals, considering their potential clinical implications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 2","pages":"81-93"},"PeriodicalIF":5.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reaching ADHD Treatment Targets?","authors":"Søren Dalsgaard,&nbsp;Maj-Britt Posserud,&nbsp;Kamilla W. Miskowiak,&nbsp;Kenneth K. C. Man","doi":"10.1111/acps.13815","DOIUrl":"https://doi.org/10.1111/acps.13815","url":null,"abstract":"&lt;p&gt;In a recent epidemiological study, Grøntved et al. present important results on the temporal changes of the rates in prevalence and incidence of ADHD diagnosis and use of ADHD medication in Denmark over the past two decades [&lt;span&gt;1&lt;/span&gt;]. The authors have applied stringent, robust, and sound methods in analyzing individual-level data available from the Danish nationwide registers. Their main findings include consistent increases in the prevalence and incidence of diagnosis of ADHD and corresponding increases in pharmacological treatment across sex and age groups from 2000 to 2022. The most notable increase in recent years is observed in young adult women. They found that 3.03% of the total population living in Denmark was given a clinical diagnosis of ADHD or had received treatment with ADHD medication in 2022. Among children and adolescents aged 6–18 years, it was 4.0%; in adults aged 18–27 years, it was 7.1%; in adults aged 27–35 years, it was 6.1%; and in adults aged 35–50 years, it was 3.5%, all as observed in 2022.&lt;/p&gt;&lt;p&gt;The study offers valid and precise estimates of the number of individuals diagnosed with ADHD or treated with ADHD medications within the entire Danish population and of the increases in those rates over a 20-year period. Such high-quality population-based estimates of the yearly prevalence and incidence of ADHD are much needed, as these measures of occurrence focus on the absolute risk, answering the question “What is the actual percentage?” Many articles in news media [&lt;span&gt;2, 3&lt;/span&gt;] and also some scientific studies [&lt;span&gt;4&lt;/span&gt;] only focus on the relative increase in number of diagnosed or treated over a certain time period, not on the prevalence rate. Similarly, a former Minister of Health in Denmark [&lt;span&gt;5&lt;/span&gt;], and some governmental reports from authorities have raised concerns about the relative increase in the use of ADHD medication, while others have reported incorrect prevalence rates of clinical diagnoses of ADHD, as they have relied on too simplistic methodologies [&lt;span&gt;6&lt;/span&gt;]. The study by Grøntved et al. overcomes such methodological limitations and reports valid and less biased estimates of the rates of prevalence and incidence of ADHD diagnosis and treatment. This is important, because in order to evaluate whether there is reason for concerns about over-diagnosing or overtreatment of ADHD, one needs to compare the rates of diagnoses and use of ADHD medication with the expected occurrence of the disorder.&lt;/p&gt;&lt;p&gt;Studies on the underlying occurrence of ADHD in the population suggest that 6%–7% of all children and adolescents fulfill diagnostic criteria for the disorder [&lt;span&gt;7&lt;/span&gt;], and the occurrence in the population seems to have been stable for several decades [&lt;span&gt;8, 9&lt;/span&gt;]. In adults, 4%–5% of the population fulfill diagnostic criteria for ADHD [&lt;span&gt;10&lt;/span&gt;]. These studies also show that children and adolescents fulfilling diagnostic criteria for ADHD are less common in g","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 1","pages":"3-5"},"PeriodicalIF":5.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13815","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial on: The Underappreciated Importance of Mania","authors":"Susan L. McElroy,&nbsp;Mark A. Frye,&nbsp;Balwinder Singh","doi":"10.1111/acps.13814","DOIUrl":"https://doi.org/10.1111/acps.13814","url":null,"abstract":"&lt;p&gt;In this issue of Acta Psychiatrica Scandinavica, Drs. Manchia, Miola, Tondo, and Baldessarini [&lt;span&gt;1&lt;/span&gt;] provide an important study of individuals with unipolar mania (UPM), defined by these authors as mania or hypomania without depressive episodes. In their study, Manchia and colleagues identified 63 consecutive individuals with UPM and compared them over the long term (up to 9.18 years) to 1210 patients with regular bipolar disorder (mania or hypomania with depressive episodes; BD) recruited from expert mood disorder centers across Italy. Compared with regular BD, the authors found that UPM was uncommon (4.5% of all BD cases over 18.2 years of risk), more common in men, predominantly BD type I (only 0.314% had unipolar hypomania), associated with more psychosis but less suicidality, and associated with greater use of antipsychotics, lithium, and mood-stabilizing anticonvulsants but much less use (27% less) of antidepressants. Over a mean follow-up of 9.18 years, the rate of UPM decreased, suggesting that some of these patients will eventually develop a first depressive episode.&lt;/p&gt;&lt;p&gt;Many of these findings have been noted in earlier, mostly cross-sectional studies using various definitions of UPM. For example, in a 2023 meta-analysis of 21 studies, UPM was similarly uncommon and associated with male gender and psychotic features, but with fewer suicide attempts [&lt;span&gt;2, 3&lt;/span&gt;]. Other findings have included higher rates of hyperthymia, good sleep quality, and morning chronotype in UPM than in regular BD [&lt;span&gt;2-4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;We were particularly interested in three issues arising from this important article.&lt;/p&gt;&lt;p&gt;First is regarding the prevalence of UPM. Many studies have suggested that UPM is a relatively uncommon form of BD. Thus, the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) found that, using three definitions of UPM, 5.0%–7.2% of individuals from the U.S. with BD type I never had depression [&lt;span&gt;5&lt;/span&gt;]. However, evidence exists that UPM may be more common in low-income versus high-income countries. Thus, a study from Ethiopia found 41.7% of participants had UPM [&lt;span&gt;6&lt;/span&gt;], while a study from Tunisia found a rate of 56.6% [&lt;span&gt;7&lt;/span&gt;]. Although these differences in prevalence rates could be due to methodological issues, including use of different definitions of UPM, one wonders if there are cultural differences regarding the etiology and recognition of BD, particularly manic symptoms. If such cultural issues exist, it would be important to understand them.&lt;/p&gt;&lt;p&gt;Second is the finding that morning chronotype may be more common in UPM while evening chronotype appears to be more common in regular BD. Our group indeed found that evening chronotype was more common among individuals participating in a BD biobank, and that it was associated with more depressive episodes than participants with non-evening chronotypes [&lt;span&gt;8&lt;/span&gt;]. Circadian rhythm dysfunction has been implicated in t","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"151 6","pages":"651-652"},"PeriodicalIF":5.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13814","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Childhood Trauma on the Real-World Effectiveness of Ketamine in Adults With Treatment-Resistant Depression","authors":"Danica E. Johnson,&nbsp;Nelson B. Rodrigues,&nbsp;Rodrigo B. Mansur,&nbsp;Roger S. McIntyre,&nbsp;Joshua D. Rosenblat","doi":"10.1111/acps.13812","DOIUrl":"https://doi.org/10.1111/acps.13812","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Childhood trauma is a well-established risk factor for major depressive disorder (MDD) and is often associated with attenuated response to conventional antidepressant therapies. Ketamine has emerged as an effective treatment for treatment-resistant depression (TRD), but the impact of childhood trauma on its effectiveness remains unclear. Herein, we aimed to determine whether childhood trauma influences the antidepressant effectiveness of ketamine in TRD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was performed on data from adults with TRD (<i>n</i> = 83) who received four ketamine infusions at a community outpatient clinic. Participants were categorized based on cumulative trauma load (high vs. low) and specific trauma types, assessed by the Childhood Trauma Questionnaire (CTQ). Depressive symptoms were measured using the Quick Inventory of Depressive Symptomatology Self-Report 16-item (QIDS-SR16) at baseline and following each infusion. Linear mixed models and chi-square tests were used to evaluate the impact of trauma on ketamine's antidepressant effectiveness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Depressive symptoms significantly decreased across all participants over time, with an average reduction of 5.7 points in QIDS-SR16 scores (<i>p</i> &lt; 0.001). High childhood trauma load was reported by 55% of participants. Response rates were 25% in the high trauma load group and 19% in the low trauma load group, while remission rates were 14% and 11%, respectively. However, there were no significant differences in antidepressant effectiveness (<i>p</i> = 0.572), response rates (<i>p</i> = 0.230), or remission rates (<i>p</i> = 0.397) between participants with high versus low trauma loads. Further analysis also revealed no significant associations between specific types of childhood trauma and antidepressant effectiveness, response, or remission outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Childhood trauma did not attenuate ketamine's antidepressant effectiveness in TRD. These findings support ketamine as a viable treatment for individuals with TRD, including those with significant trauma histories. Further research is warranted to replicate these findings and explore underlying mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 2","pages":"134-145"},"PeriodicalIF":5.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy and Acceptability of Non-Invasive Brain Stimulation Interventions for Obsessive-Compulsive Disorder Management: A Network Meta-Analysis Based on 24 Stimulation Methods","authors":"Ping-Tao Tseng,&nbsp;Chih-Wei Hsu,&nbsp;Chao-Ming Hung,&nbsp;Chih-Sung Liang,&nbsp;Hung-Yu Wang,&nbsp;Brendon Stubbs,&nbsp;Andre F. Carvalho,&nbsp;Andre R. Brunoni,&nbsp;Kuan-Pin Su,&nbsp;Yu-Kang Tu,&nbsp;Yi-Cheng Wu,&nbsp;Tien-Yu Chen,&nbsp;Dian-Jeng Li,&nbsp;Pao-Yen Lin,&nbsp;Yen-Wen Chen,&nbsp;Kuo-Chuan Hung,&nbsp;Jiann-Jy Chen,&nbsp;Bing-Syuan Zeng,&nbsp;Cheng-Ta Li","doi":"10.1111/acps.13809","DOIUrl":"10.1111/acps.13809","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Despite the high lifetime prevalence and elevated disability rates, treatments for obsessive-compulsive disorder (OCD) have limited efficacy. Considering the abnormal connectivity in the cortical-striatal-thalamic-cortical loop circuits in OCD, several randomized controlled trials (RCTs) have addressed the efficacy of different non-invasive brain stimulation (NIBS) modalities for the management of OCD. However, these RCTs yielded inconclusive results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This network meta-analysis (NMA) included RCTs of NIBS interventions, such as transcranial direct current stimulation (tDCS) and various repetitive transcranial magnetic stimulation (rTMS), in OCD patients. The primary outcomes were changes in the overall severity of OCD and acceptability (i.e., dropout rates).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This NMA of 34 eligible RCTs (1089 participants) and 24 different NIBS interventions revealed that three NIBS interventions significantly improved overall OCD severity compared with sham controls, which were high-frequency rTMS over the dorsolateral prefrontal cortex (DLPFC) [mean difference (MD) = −10.81, 95% confidence intervals (95% CIs) = −20.80 to −0.82], high-frequency deep TMS over the dorsal medial prefrontal cortex/anterior cingulate cortex (dmPFC/ACC) (MD = −9.74, 95% CIs = −16.42 to −3.06), and low-frequency rTMS over the right DLPFC (MD = −4.70, 95% CIs = −8.84 to −0.57).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlighted that excitatory stimulation over the dmPFC/ACC and bilateral DLPFC, or inhibitory stimulation over the right DLPFC, was associated with significant improvements in overall OCD severity. Further large-scale RCTs with longer follow-up periods are needed to investigate the true impact of NIBS-based intervention to manage OCD.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b>PROSPERO: CRD42023394953</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 2","pages":"112-124"},"PeriodicalIF":5.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrelationships of Changes in Outcome Domains in Patients With Schizophrenia Spectrum Disorders: A Meta-Analysis","authors":"Lars de Winter,&nbsp;Auke Jelsma,&nbsp;Jentien M. Vermeulen,&nbsp;Astrid Vellinga,&nbsp;Jaap van Weeghel,&nbsp;Ilanit Hasson-Ohayon,&nbsp;Cornelis L. Mulder,&nbsp;Nynke Boonstra,&nbsp;Wim Veling,&nbsp;Lieuwe de Haan","doi":"10.1111/acps.13808","DOIUrl":"10.1111/acps.13808","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Patients with schizophrenia spectrum disorders (SSD) improve in several outcome domains over the course of illness, but to different degrees. In this meta-analysis, we investigated whether longitudinal changes in different outcome domains are associated with each other and which factors moderate these changes over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Our protocol was preregistered in PROSPERO (CRD42024504253). We included 109 studies, identified through searches in PsycInfo, PubMed, CINAHL, and Cochrane up until November 2023, investigating longitudinal changes in at least two outcome domains (symptoms, social functioning, cognition or personal recovery) for patients with SSD with at least 1 year follow-up. We calculated Pearson correlation coefficients for associations of changes between outcome domains. Potential moderating effects of demographic, clinical, social, or study characteristics were explored. Quality assessment was executed using the QUIPS tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found substantial positive associations between changes in symptoms, social functioning, and cognition. Especially, changes in negative symptoms and overall social functioning were associated with changes in several outcome domains. Changes in personal recovery were only associated with changes in symptoms. We found more substantial improvements in combinations of outcomes for patients with a shorter illness duration, females, a lower percentage of patients diagnosed with schizophrenia, and patients receiving treatment focused on targeted outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Symptoms, social functioning, and cognition often concurrently improve and may boost each other. This suggests that an integrated approach targeting several outcome domains jointly boosts long-term improvement. However, changes in personal recovery seem to occur separately from other outcome domains. Therefore, targeted attention for personal recovery is needed.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> PROSPERO: CRD42024504253</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 1","pages":"6-26"},"PeriodicalIF":5.3,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Higher Dose-Adjusted Clozapine Concentrations in Non-Smokers With High CRP Levels May Be Associated With the Lower Daily Doses of Clozapine","authors":"Yuki Kikuchi","doi":"10.1111/acps.13810","DOIUrl":"10.1111/acps.13810","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 2","pages":"148-149"},"PeriodicalIF":5.3,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Incidence of Attention Deficit/Hyperactivity Disorder in Denmark. A National Register-Based Open Cohort Study","authors":"Simon Grøntved,&nbsp;Kathrine Hald,&nbsp;Christina Mohr-Jensen,&nbsp;Søren Paaske Johnsen,&nbsp;Jan Mainz,&nbsp;Jan Brink Valentin","doi":"10.1111/acps.13804","DOIUrl":"10.1111/acps.13804","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Rises in prevalence and incidence of the neurodevelopmental disorder Attention-deficit/Hyperactivity Disorder (ADHD) have been reported globally and estimated in Denmark previously. Nevertheless, differences in methodology hinder an assessment of the temporal evolution of ADHD based on published literature. The aim of this study was to consistently calculate the yearly prevalence and incidence proportions of ADHD and the use of ADHD medication in Denmark from 2000 to 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted an open cohort study using register data covering the entire Danish population. We defined ADHD as either having a hospital diagnosis of ADHD (ICD-10: F90.0, F90.1, F90.8, or F98.8), or having redeemed a prescription for ADHD medication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the included 7,748,837 persons, 2.52% had ADHD, of whom 58.33% were males. The prevalence of ADHD has increased from 0.10% in 2000 to 3.03% in 2022. Specifically for the 18–27-year-olds, the prevalence was 8.16% for males and 6.12% for females in the year 2022. For the incidence, the same age group peaked within the females in 2022 at 1.10%, whereas the male incidence was consistently highest in the 6–18-year-olds, peaking in 2022 at 0.94%. Total use of ADHD medication in the population also increased. Methylphenidate was used by 97.58% of the ADHD medicated patients in 2000 and 70.60% in 2022. Lisdexamphetamine was the second most common in 2022, where 24.03% redeemed a prescription.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limitations</h3>\u0000 \u0000 <p>Incidence and prevalence were calculated specifically for the Danish population and may not be directly generalizable to other countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prevalence of ADHD has consistently increased throughout the past two decades. The main contribution to this increase is the ADHD incidence in females, especially young females in the most recent years 2020–2022. Methylphenidate was consistently the most common ADHD drug prescribed, though lisdexamphetamine use has increased in recent years.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 1","pages":"27-38"},"PeriodicalIF":5.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13804","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There Solid Evidence to Corroborate the Augmentation With Prazosin in Depression With Trauma?","authors":"Victor Domingueti Vallim Fonseca,&nbsp;Letícia Braga Martins,&nbsp;Luísa Weber Bisol,&nbsp;Fabio Gomes de Matos e Souza","doi":"10.1111/acps.13807","DOIUrl":"10.1111/acps.13807","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 1","pages":"77-78"},"PeriodicalIF":5.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “A Systematic Review and Meta-Analysis of the Association Between Childhood Maltreatment and Adult Depression”","authors":"Shubham Kumar,&nbsp;Rachana Mehta,&nbsp;Ranjana Sah","doi":"10.1111/acps.13805","DOIUrl":"10.1111/acps.13805","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 2","pages":"146-147"},"PeriodicalIF":5.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}