Acta Psychiatrica Scandinavica最新文献

{"title":"Validation of the Catatonia Quick Screen in the Original Bush-Francis Catatonia Rating Scale Cohort.","authors":"James Luccarelli, Joshua Ryan Smith, Mark Kalinich, Jo Ellen Wilson, Jonathan P Rogers, Stephan Heckers, Andrew Francis","doi":"10.1111/acps.70135","DOIUrl":"https://doi.org/10.1111/acps.70135","url":null,"abstract":"<p><strong>Introduction: </strong>Delayed catatonia diagnosis may cause preventable harm. The 4-item Catatonia Quick Screen (CQS) allows rapid screening, but its specificity requires evaluation. We assessed CQS sensitivity and specificity using the original Bush Francis Catatonia Rating Scale (BFCRS) cohort.</p><p><strong>Methods: </strong>Retrospective reanalysis of data from 215 consecutive inpatient psychiatric admissions. CQS classifications were compared against BFCRS, DSM-5-TR, and ICD-11 criteria. 95% confidence intervals (CIs) were calculated via Clopper-Pearson exact methods, treating the eight single-sign patients conservatively as false positives.</p><p><strong>Results: </strong>All 15 catatonia cases screened positive (true positives). The CQS demonstrated 100% sensitivity (95% CI: 78.2% to 100%), 96.0% specificity (95% CI: 92.3% to 98.3%), 65.2% positive predictive value (95% CI: 42.7% to 83.6%), and 100% negative predictive value (95% CI: 98.1% to 100%).</p><p><strong>Conclusion: </strong>The CQS showed excellent sensitivity and high specificity in this psychiatric cohort. It serves as a rapid, low-burden screening tool to accelerate clinical recognition, though positive results require formal diagnostic confirmation.</p>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Dissociation and Childhood Trauma in Borderline Personality Disorder and Affective Disorders: A Network Analytic Approach.","authors":"Philipp Wülfing, Carsten Spitzer, Judy Leibowitz, Stephen Pilling, Peter Fonagy, P Read Montague, Tobias Nolte","doi":"10.1111/acps.70131","DOIUrl":"https://doi.org/10.1111/acps.70131","url":null,"abstract":"<p><strong>Background: </strong>Dissociation and childhood trauma are strongly associated with borderline personality disorder (BPD), yet it remains unclear whether this reflects disorder-specific mechanisms or differences in symptom severity within a shared transdiagnostic structure.</p><p><strong>Objective: </strong>Using network analysis, we examined whether the conditional dependency architecture linking childhood trauma, dissociation, posttraumatic stress symptoms, and general psychological distress differs between individuals diagnosed with BPD and affective disorders (AD).</p><p><strong>Method: </strong>Participants were drawn from a large outpatient clinical sample and matched on age, gender, and global symptom severity (BSI-GSI). Networks were estimated using regularized partial correlation models including CTQ subscales, DES subscales, PTSD symptom clusters, and overall distress. Network Comparison Tests assessed structural invariance and global strength differences between diagnostic groups.</p><p><strong>Results: </strong>As expected, individuals with BPD reported significantly higher levels of childhood trauma and dissociation than those with AD. However, despite these marked differences in severity, the overall network structure did not significantly differ between groups, and global connectivity was comparable. Bridge centrality analyses indicated similar patterns of interconnection across trauma, dissociation, and PTSD domains in both diagnoses.</p><p><strong>Conclusions: </strong>These findings suggest that BPD is characterized by elevated severity within a largely shared trauma-dissociation architecture, rather than by a qualitatively distinct network configuration. The results support a transdiagnostic model in which childhood trauma and dissociative processes are embedded within a common psychopathological structure, with diagnostic distinctions reflecting differences in magnitude rather than rewiring of interrelations. This severity-versus-architecture distinction has implications for understanding mechanisms of vulnerability and for targeting shared pathways across diagnostic categories.</p>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Stratified Patterns of Suicide Methods in Bipolar Disorder: A Nationwide Cohort Study.","authors":"Meng-Chiao Chou, Po-Yu Chen, Yueh-Pin Lin, Win-Yin Chen, Sheng-Siang Su, Shang-Ying Tsai, Chiao-Chicy Chen, Chian-Jue Kuo","doi":"10.1111/acps.70132","DOIUrl":"https://doi.org/10.1111/acps.70132","url":null,"abstract":"<p><strong>Objectives: </strong>Age-stratified suicide methods in bipolar disorder remain underexplored. This study compared method selection between suicide decedents with bipolar disorder and the general population.</p><p><strong>Methods: </strong>We identified 47,488 individuals with bipolar disorder between 2003 and 2023 from Taiwan's nationwide health database and linked mortality records to ascertain suicide deaths. Using a decedent-only design, we compared the distribution of suicide methods between suicide decedents with bipolar disorder and those from the general population. Age-stratified (< 30, 30-49, 50-64, and ≥ 65 years) multivariable logistic regression analyses were performed with adjustment for sex, age at death, urbanization level, and employment status.</p><p><strong>Results: </strong>Among 1452 suicide deaths over 478,729 person-years (incidence: 303.3 per 100,000), the most common methods were hanging (28.0%), charcoal burning and other gas poisoning (20.9%), jumping from a high place (18.0%), drug overdose (16.9%), and drowning (11.4%). Suicide decedents in the bipolar cohort had higher odds of drowning (adjusted odds ratio [aOR]: 1.70, 95% confidence interval [CI]: 1.44-2.00) and jumping from a high place (aOR: 1.31, 95% CI: 1.14-1.50) but lower odds of charcoal burning and other gas poisoning (aOR: 0.69, 95% CI: 0.60-0.79) and hanging (aOR: 0.87, 95% CI: 0.77-0.98) than did general-population decedents (n = 81,159). Age-stratified analyses showed charcoal burning concentrated in younger and middle-aged decedents, drowning consistently elevated across age strata, and jumping elevated in middle-aged and older decedents.</p><p><strong>Conclusion: </strong>Individuals with bipolar disorder who die by suicide exhibit distinct, age-dependent patterns of suicide methods. Therefore, prevention strategies should be tailored to both age groups and methods.</p>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive Transcranial Magnetic Stimulation (rTMS) for Adolescent Depression: A Systematic Review and Meta-Analysis of Treatment Response and Suicidal Ideation Reduction","authors":"Lidija Rakic,&nbsp;Floris Tas,&nbsp;Miao Chen,&nbsp;Indira Tendolkar,&nbsp;Philip van Eijndhoven,&nbsp;Jozarni Dlabac-de Lange,&nbsp;Mieke Klein Hofmeijer,&nbsp;Adriaan Hoogendoorn,&nbsp;Didi Rhebergen","doi":"10.1111/acps.70110","DOIUrl":"10.1111/acps.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Major depressive disorder (MDD) affects 11%–19% of adolescents globally. Early treatment is vital, but the risk of relapse is high, with 46% relapse within 5 years, which threatens a chronic course. Hence, better solutions are needed. Repetitive transcranial magnetic stimulation (rTMS) is effective in adults, but its use in adolescents is limited. While studies—including trials and meta-analyses—exist, their generalizability is unclear. This review evaluates rTMS's efficacy and safety for adolescent MDD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following PRISMA guidelines, a comprehensive literature review was conducted using English-language databases Embase, PubMed, PsycINFO, and the Cochrane Database of Systematic Reviews. We included studies published up to February 2025. Data were pooled to calculate standardized mean change (SMC), proportions, log odds ratios, and their respective 95% confidence intervals (CI), measuring effectiveness, response rate, and suicidality. We systematically described adverse effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 687 studies, 42 underwent full-text assessment, and 19 were included. The within-intervention group pooled SMC between pre-post scores of depression severity was −2.15 (95% CI [−2.58, −1.73]), indicating a strong effect but with high heterogeneity (<i>I</i>\u0000 ² = 87.13%). For RCT-only studies, the pooled SMC was −0.90 (95% CI [−1.90, 0.11]), showing a smaller effect. The pooled response rate was 54% (95% CI [42%; 66%]) with similarly high heterogeneity (<i>I</i>\u0000 ² = 82.25%). A large reduction in suicidal ideation was observed (pooled SMC = −2.78, 95% CI [−5.98, 0.42]), albeit this was based on a limited number of studies (<i>n</i> = 3) and the SMC was not statistically significant. Mild and transient adverse effects were reported. The majority of studies were rated as having a high risk of bias.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings demonstrated that rTMS is effective, safe, and well-tolerated by adolescents with MDD. However, high heterogeneity of methods, bias, and inclusion of uncontrolled trials demand more rigorous trials, whereby adaptive designs could potentially increase the empirical availability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"154 3","pages":"187-202"},"PeriodicalIF":4.7,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Position and Somatic Comorbidity in Mental Disorders","authors":"Martin Tesli,&nbsp;Vidar Hjellvik,&nbsp;Simon Lergenmuller,&nbsp;Gabriela Hjell,&nbsp;Andreas Jangmo,&nbsp;Marit Haram,&nbsp;Ingvild Odsbu,&nbsp;Inger Ariansen,&nbsp;Steinar Krokstad,&nbsp;Øyvind Næss,&nbsp;Lars J. Kjerpeseth,&nbsp;Wenche Nystad,&nbsp;Jørgen G. Bramness","doi":"10.1111/acps.70113","DOIUrl":"10.1111/acps.70113","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Individuals with mental disorders face an elevated risk for somatic noncommunicable diseases (NCD), such as cardiovascular disease (CVDs), chronic obstructive pulmonary disease (COPD), diabetes, and cancer. Low socioeconomic position (SEP) is linked to both mental disorders and somatic NCDs, but its role in this association remains unclear. Here, we provide a comprehensive overview of how associations between mental disorders and somatic NCDs vary by SEP indicators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data on all adult individuals resident in Norway from 01.01.2008 to 01.01.2010 (<i>N</i> = 3,589,719) were derived from a nationwide registry linkage including information on primary and secondary health care, dispensed drugs, causes of death, and socioeconomic factors. We assessed four broad types of mental disorders (psychotic, bipolar, depressive and anxiety disorders) and four categories of somatic NCDs (CVD, COPD, diabetes, cancer) diagnosed during follow-up from 01.01.2010 to 31.12.2020. Educational attainment and household income were used as SEP indicators, in addition to parental educational attainment. Cox regression models estimated hazard ratios for somatic NCDs among individuals with mental disorders compared to the general population, adjusting for and stratifying by SEP, sex, and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All mental disorders were associated with an increased risk of somatic NCDs, strongest for COPD and weakest for cancer. Risk increased with disorder severity, with psychotic and bipolar disorders showing the strongest associations. Young adults with psychosis had a 4–5-fold increased risk of diabetes and COPD. Low SEP was associated with both mental disorders and somatic NCDs with moderate attenuating effects in their co-occurrence and little variation across SEP strata.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We found an increased risk of somatic NCDs in individuals with mental disorders and identified young adults with psychosis as a particularly vulnerable subgroup. Low SEP compounds this burden, underscoring the need for integrated mental and somatic healthcare strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"154 3","pages":"234-243"},"PeriodicalIF":4.7,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148025196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric History and Postpartum Depression: The Mediating Role of Obstetric Complications","authors":"Mette-Marie Zacher Kjeldsen,&nbsp;Katrine Holde,&nbsp;Line Bager,&nbsp;Veerle Bergink,&nbsp;Emely Ek Blæhr,&nbsp;Janne Tidselbak Larsen,&nbsp;Kathrine Bang Madsen,&nbsp;Merete Lund Mægbæk,&nbsp;Liselotte Vogdrup Petersen,&nbsp;Trine Munk-Olsen","doi":"10.1111/acps.70105","DOIUrl":"10.1111/acps.70105","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Psychiatric history is the strongest risk factor for postpartum depression (PPD). Obstetric complications, more prevalent among women with a psychiatric history, are also independent risk factors. However, the mechanisms linking these factors to PPD remain unclear. We examined whether obstetric complications mediate the association between psychiatric history and PPD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort study utilized Danish nationwide Edinburgh Postnatal Depression Scale (EPDS) screenings (2015–2021) linked with register data. Psychiatric history was defined as psychiatric diagnoses (ICD-10: F00-99) or filled psychotropic prescriptions (ATC: N05A, N05BE01, N06A, N06BA) from 1995 until conception. Complications were defined as a composite measure of complications occurring between conception and delivery. <i>PPD symptoms</i> were defined as a positive EPDS score (≥ 11), and <i>PPD diagnosis</i> was defined as a depression diagnosis (ICD-10: F32-33) or antidepressant prescription fill (ATC: N06A indicated for depression).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 170,218 mothers (163,326 in analyses), 23.9% had a psychiatric history. These mothers had higher levels of PPD symptoms (13.4% vs. 6.1%), PPD diagnosis (7.0% vs. 0.4%), and complications (34.1% vs. 28.5%) compared to those without. (A) Psychiatric history (PPD symptoms: OR = 2.32 [95% CI, 2.22; 2.41]; PPD diagnosis: OR = 5.09 [95% CI, 4.48; 5.79]) and complications (PPD symptoms: OR = 1.16 [95% CI, 1.11; 1.21]; PPD diagnosis: OR = 1.18 [95% CI, 1.04; 1.34]) were independently associated with PPD. (B) Psychiatric history did not modify the association between complications and PPD (PPD symptoms: OR = 1.20 [95% CI, 1.14; 1.26] vs. 1.09 [95% CI, 1.02; 1.17]; PPD diagnosis: OR = 1.22 [95% CI, 1.00; 1.49] vs. 1.15 [95% CI, 0.97; 1.36]). (C) Complications mediated only a small fraction of the association between psychiatric history and PPD (proportion mediated: PPD symptoms = 0.68% [95% CI, 0.50%; 1.00%], PPD diagnosis = 0.42% [95% CI, 0.14%; 0.79%]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Psychiatric history and complications are independently associated with PPD, but complications explain only a negligible portion. These findings suggest that the link between psychiatric vulnerability and PPD is primarily driven by direct mechanisms rather than mediation through complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"154 3","pages":"223-233"},"PeriodicalIF":4.7,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.70105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of ADHD and Compliance in Relation to ADHD Medication","authors":"Kim Berg Johannessen,&nbsp;Pelle Lau Ishøy,&nbsp;Tine Houmann,&nbsp;Eline Levin,&nbsp;Per Hove Thomsen","doi":"10.1111/acps.70106","DOIUrl":"10.1111/acps.70106","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;ADHD medication has proven effective for treating ADHD in adults. Large registry-based studies have generally reported high discontinuation rates over time and focused on different risk factors, including comorbidity, gender, and socioeconomic status. The present mixed-model study examines self-reported factors related to the discontinuation of ADHD medication in Danish adults. It specifically focuses on themes such as the perception of ADHD and the perceived beneficial and adverse effects of the medication, with the aim of identifying patients' reasons either for continuing or discontinuing the prescribed medication overall and in relation to gender.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The present study explores patients' self-reported reasons for continuing or discontinuing ADHD medication, as well as the factors that influence their decision to live with or without medication despite having ADHD.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The present study employed a mixed-model design and consisted of 1050 Danish adults who redeemed a prescription for ADHD medication for the first time between 2017 and 2019. Questionnaires were distributed by Statistics Denmark to 4748 adults, a representative sample of the 16,284 Danish adults who redeemed a prescription within that period. Discontinuation was defined as a gap of 12 months between redemptions, and questionnaires were sent to an equal number of patients who continued or discontinued ADHD medication. A series of 2 (continuation vs. discontinuation) × 2 (male vs. female) two-way ANOVA was conducted for different main themes, all of which were derived from six patient interviews.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The patients who continued medical treatment were more likely to perceive ADHD as a biological illness, whereas those who discontinued treatment were more likely to perceive ADHD as an illness constructed by society. Furthermore, patients who continued medical treatment reported that the medication had a more positive influence on their lives, whereas those who discontinued the medication reported experiencing more negative feelings. Finally, males were more likely than females to perceive ADHD as a socially created illness, while females reported higher scores than males for taking ADHD medication for themselves, being able to work or attend school, being social, and being able to enjoy peaceful alone.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 ","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"154 3","pages":"212-222"},"PeriodicalIF":4.7,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147968796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Maltreatment and Biomarkers in Neuropsychiatric Disorders","authors":"Natalia E. Fares-Otero,&nbsp;Soraya Seedat","doi":"10.1111/acps.70107","DOIUrl":"10.1111/acps.70107","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"154 3","pages":"244-246"},"PeriodicalIF":4.7,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Attention Deficit Hyperactivity Disorder Medication Among Danish Children and Adolescents From 2010 to 2023","authors":"Maria Højgaard Stoltz-Andersen,&nbsp;Martin Thomsen Ernst,&nbsp;Søren Dalsgaard,&nbsp;Lotte Rasmussen,&nbsp;Rikke Wesselhoeft","doi":"10.1111/acps.70103","DOIUrl":"10.1111/acps.70103","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Pharmacological treatment is an important component in the multimodal management of <i>attention deficit hyperactivity disorder</i> (ADHD), but contemporary trends in ADHD medication use among boys and girls in Denmark have not been fully characterized. This study aimed to provide an updated and detailed description of ADHD medication use among Danish children and adolescents during 2010–2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed filled prescriptions for ADHD medication in youths aged 5–17 years in Denmark (2010–2023), calculating incidence rates, prevalence proportions, male/female ratios, treatment persistence, age at initiation, and prescriber setting. Analyses were stratified by sex and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The incidence rates of ADHD medication use followed a u-shaped pattern for boys, declining from 0.59 per 100 person-years in 2010 to 0.34 in 2014, before rising to 1.0 in 2023. Among girls, incidence rates increased continuously from 0.20 per 100 person-years in 2010 to 0.67 per 100 person-years in 2023. Prevalence proportions were stable until 2018, where an increase was observed for both sexes, reaching 3.4% for boys and 1.8% for girls in 2023. The male/female incidence and prevalence ratios decreased consistently from 2010 to 2023. ADHD medication was initiated at a median age of 13 years for girls and 11 years for boys. The share of index prescriptions from child and adolescent psychiatry increased, reaching 87% in 2023. Most 5–9-year-olds (65%) and almost half of 10–13-year-olds (45%) were covered by an ADHD medication prescription 5 years after treatment initiation, as opposed to 29% of 14–17-year-olds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ADHD medication use in Denmark increased from 2010 to 2023, particularly among girls, where the prevalence tripled compared to a 1.5-fold increase in boys. This likely reflects greater awareness of ADHD in girls, although their 2-year treatment delay compared to boys warrants clinical attention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"154 3","pages":"203-211"},"PeriodicalIF":4.7,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressants and Psychosis Risk: Disentangling Causal Effects From Prognostic Signals","authors":"Andrea Raballo,&nbsp;Michele Poletti,&nbsp;Antonio Preti","doi":"10.1111/acps.70108","DOIUrl":"10.1111/acps.70108","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"154 3","pages":"247-249"},"PeriodicalIF":4.7,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}