Unravelling the Link Between Body Mass Index and Cognitive Performance in Individuals With Bipolar Disorder and Exploration of PRS Moderation Effect: Findings From the PsyCourse Study.

IF 5 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2025-08-31 DOI:10.1111/acps.70028

B Solé, L Montejo, M Budde, M Valentí, R Borràs, S Martín-Parra, A Ruiz, A Martínez-Aran, K Adorjan, M Heilbronner, A Navarro-Flores, M Oraki Kohshour, D Reich-Erkelenz, E C Schulte, F Senner, I G Anghelescu, V Arolt, B T Baune, U Dannlowski, D E Dietrich, A J Fallgatter, C Figge, G Juckel, C Konrad, J Reimer, E Z Reininghaus, M Schmauß, C Spitzer, J Wiltfang, J Zimmermann, P Falkai, E Vieta, T G Schulze, C Torrent, U Heilbronner, S Papiol

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引用次数: 0

Abstract

Introduction: Bipolar disorder (BD) is a severe mental disorder characterized by extreme mood swings, often accompanied by metabolic comorbidities, such as cardiovascular disease, which increase mortality and reduce quality of life. Both metabolic dysfunctions and BD are associated with cognitive dysfunction. Body mass index (BMI) is closely linked to metabolic health and cognitive performance. This study examined the link between BMI and cognitive function in individuals with BD and how genetic factors, namely polygenic risk scores (PRS) for BD and BMI, might influence this link.

Methods: Genetic (PRS scores) and phenotypic data (sociodemographic factors, clinical symptoms and cognitive function) of 341 adult patients with BD diagnosis from the PsyCourse Study, a large, multi-site, and naturalistic longitudinal study, were utilized for this study. First, we performed univariate and multivariate regression analyses to investigate associations between BMI and cognitive performance. Second, moderation analyses were conducted to examine the potential moderator effects of BD-PRS or BMI-PRS in the relationship between BMI and different cognitive outcomes.

Results: BMI was associated with processing speed (TMT-A) and executive function (TMT-B), with individuals with higher BMI showing poorer performance. Moderation analyses revealed that the effect of BMI on cognition was moderated by BD-PRS only regarding the processing speed. BMI-PRS did not moderate the association between BMI and cognitive variables.

Conclusions: Our findings indicate that the relationship between BMI and cognitive impairment in BD is partially moderated by BD genetic liability but not by BMI genetic load.

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揭示双相情感障碍个体体重指数与认知表现之间的联系及PRS调节效应的探索：来自PsyCourse研究的结果。

简介：双相情感障碍（BD）是一种以极端情绪波动为特征的严重精神障碍，常伴有代谢合并症，如心血管疾病，增加死亡率，降低生活质量。代谢功能障碍和双相障碍都与认知功能障碍有关。身体质量指数（BMI）与代谢健康和认知能力密切相关。本研究探讨了双相障碍患者的BMI和认知功能之间的联系，以及遗传因素，即双相障碍和BMI的多基因风险评分（PRS）如何影响这种联系。方法：采用PsyCourse研究中341例成年双相障碍患者的遗传（PRS评分）和表型数据（社会人口学因素、临床症状和认知功能），这是一项大型、多地点、自然的纵向研究。首先，我们进行了单变量和多变量回归分析，以调查BMI和认知表现之间的关系。其次，进行适度分析，以检验BD-PRS或BMI- prs在BMI与不同认知结果之间的关系中的潜在调节作用。结果：BMI与处理速度（TMT-A）和执行功能（TMT-B）相关，BMI越高的个体表现越差。调节分析显示，BMI对认知的影响仅在加工速度上被BD-PRS调节。BMI- prs没有调节BMI和认知变量之间的关联。结论：我们的研究结果表明，BMI与双相障碍患者认知功能障碍之间的关系部分受到双相障碍遗传倾向的调节，而不受BMI遗传负荷的调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.