Association Between Age at Diagnosis of Coronary Heart Disease and Incident Depression and Anxiety.

IF 5 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2025-08-05 DOI:10.1111/acps.70021

Jie Liang, Qiongwei Li, Yang Pan, Wenya Zhang, Darui Gao, Yanyu Zhang, Jingya Ma, Yuling Liu, Yiwen Dai, Mengmeng Ji, Menghan Zhu, Xvyang Diao, Xinqing Yang, Yichi Zhang, Wuxiang Xie, Fanfan Zheng

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引用次数: 0

Abstract

Background: Whether younger age at diagnosis of coronary heart disease (CHD) is associated with a higher risk of incident depression and anxiety or not remains unexamined. This study aimed to explore the association between age at diagnosis of CHD and incident depression and anxiety.

Methods: Data were from the UK Biobank. Information on the diagnosis of CHD, depression, and anxiety was collected at baseline and follow-ups. Cox proportional hazards models and the propensity score matching method were applied.

Results: A total of 438,376 adults were included, of which 49,620 had CHD (median follow-up: 13.8 years). Compared with participants without CHD, participants with CHD were at an increased risk of incident depression and anxiety. Younger age at diagnosis of CHD (per 10-year decrement) was associated with a higher risk of depression (HR = 1.73, 95% CI: 1.65-1.82, p < 0.001) and anxiety (HR = 1.66, 95% CI: 1.57-1.74, p < 0.001). In propensity score matching analysis, CHD patients were at a higher risk of depression and anxiety than matched controls without CHD among all diagnosis age groups, and the HRs gradually elevated with descending age at CHD diagnosis.

Conclusions: Individuals diagnosed with CHD at a younger age were at an elevated risk of incident depression and anxiety than individuals diagnosed at an older age, underscoring the necessity to pay attention to their mental health and conduct timely interventions to attenuate the subsequent risk of depression and anxiety.

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冠心病诊断年龄与抑郁、焦虑的关系

背景：诊断冠心病（CHD）时较年轻是否与较高的抑郁和焦虑发生率相关仍未得到研究。本研究旨在探讨冠心病诊断年龄与抑郁、焦虑的关系。方法：数据来自UK Biobank。在基线和随访时收集冠心病、抑郁和焦虑的诊断信息。采用Cox比例风险模型和倾向评分匹配法。结果：共纳入438,376名成年人，其中49,620名患有冠心病（中位随访时间：13.8年）。与没有冠心病的参与者相比，冠心病参与者发生抑郁和焦虑的风险增加。诊断为冠心病的年龄越小（每减10年），抑郁风险越高（HR = 1.73, 95% CI: 1.65-1.82, p）。结论：诊断为冠心病的年龄越小的个体发生抑郁和焦虑的风险比年龄越大的个体高，强调有必要关注他们的心理健康，及时采取干预措施，以减轻随后发生抑郁和焦虑的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.