Acta Psychiatrica Scandinavica最新文献

{"title":"Response to: “In the Assessment of Childhood Maltreatment and Cognitive Function in Bipolar Disorder All Variables Should be Taken Into Consideration”","authors":"Natalia E. Fares-Otero, Anaid Pérez-Ramos, Ricardo Lopez-Escribano, Sara Martin-Parra, Luis Alameda, Sarah L. Halligan, Kamilla W. Miskowiak, Eduard Vieta","doi":"10.1111/acps.70020","DOIUrl":"10.1111/acps.70020","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 5","pages":"399-401"},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition in Psychiatry: Treatment Targets, Mechanisms, and Assessment Innovations.","authors":"Kamilla W Miskowiak, Katherine E Burdick","doi":"10.1111/acps.70015","DOIUrl":"https://doi.org/10.1111/acps.70015","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Improvement in Subjective Executive Functioning Following an Internet-Delivered Cognitive Enhancement Intervention for Adults in Remission From Depression.","authors":"Sunniva Brurok Myklebost, Tine Nordgreen, Eivind Haga Ronold, Aleksander Heltne, Åsa Hammar","doi":"10.1111/acps.70019","DOIUrl":"https://doi.org/10.1111/acps.70019","url":null,"abstract":"<p><strong>Introduction: </strong>Residual cognitive deficits are commonly reported by individuals in remission from depression, often affecting daily life functioning and mental health. To provide tailored and personalized cognitive enhancement interventions for this population, there is a need for a better understanding of the characteristics of those who benefit from such interventions. Therefore, this study aimed to identify predictors of changes in subjective executive functioning following an internet-delivered cognitive enhancement intervention for adults in remission from depression.</p><p><strong>Methods: </strong>Data were collected from a randomized controlled trial investigating the efficacy of an internet-delivered cognitive enhancement intervention. Changes in subjective executive functioning from pre-treatment to the six-month follow-up were assessed in 44 participants in remission from depression, using the Behavior Rating Inventory of Executive Function Adult Global Executive Composite. Linear mixed model analyses were conducted to investigate the impact of demographic, clinical, and treatment credibility variables on change in subjective cognitive functioning over time.</p><p><strong>Results: </strong>The results showed that shorter lifetime depression duration predicted greater improvements in subjective executive functioning (p = 0.031). Higher levels of treatment expectancy and credibility were related to greater improvements in subjective cognitive functioning (p = 0.024). Participants with a partner showed better treatment response than those without a partner (p < 0.001).</p><p><strong>Conclusion: </strong>This study builds on previous research on cognitive enhancement interventions in remitted depression, highlighting the impact of depression duration, treatment expectancy, and credibility on treatment response. Interventions targeting cognitive deficits appear most effective for those with a shorter lifetime duration of depression. Therefore, efforts should be made to enhance outcomes in those with a chronic course. To maximize engagement and outcomes, these interventions should be delivered in a way that individuals in remission from depression view them as credible and capable of reducing their deficits. Previous research has not found partner status to predict change in subjective executive functioning. The effect of partner status on treatment response should be investigated further.</p>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Occupations, Suicides, and Suicide Attempts: A Cohort Study Based on the Working Population in Sweden","authors":"Alicia Nevriana,&nbsp;Emma Brulin,&nbsp;Tomas Hemmingsson,&nbsp;Melody Almroth,&nbsp;Kuan-Yu Pan,&nbsp;Theo Bodin,&nbsp;Katarina Kjellberg,&nbsp;Daniel Falkstedt","doi":"10.1111/acps.70018","DOIUrl":"10.1111/acps.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Many studies have examined physicians' risk of suicide, but studies of other healthcare occupations have been fewer. Suicide attempts have also rarely been studied. We aimed to determine the risks of suicide and suicide attempts among healthcare workers in comparison with non-healthcare workers, according to occupational qualification level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This population-based cohort study linking Swedish national registers included 243,183 healthcare workers in high-qualified occupations (e.g., physicians); 1,789,076 workers in other high-qualified occupations; 514,726 healthcare workers in low-qualified occupations (e.g., assistant nurses); and 2,026,890 workers in low-qualified occupations residing in Sweden in 2005 and followed them until the latest December 31, 2020. We estimated adjusted hazard ratios (aHR) for suicide and first suicide attempt.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to non-healthcare workers, higher risks for suicide were observed for several healthcare occupations, primarily those working with patient care (e.g., aHR physicians 1.57, 95% CI: 1.23–2.00, registered nurses 1.61, 95% CI: 1.37–1.88, assistant nurses 1.25, 95% CI: 1.17–1.34), rather than those in administrative roles (aHR high-qualified healthcare administrators 1.01 95% CI: 0.76–1.35). Among physicians, the risk was most apparent for psychiatrists (aHR 2.70, 95% CI: 1.21–6.03). For suicide attempts, the risks were primarily observed among registered nurses (aHR 1.22, 95% CI: 1.15–1.29) and assistant nurses (aHR 1.15, 95% CI: 1.12–1.18). Among healthcare workers, assistant nurses had the highest incidence rates for suicide (18.7/100,000 person-years) and suicide attempts (175.1/100,000 person-years).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Workers in several healthcare occupations showed a higher risk of suicide relative to non-healthcare workers with a similar occupational qualification level. Interventions may need to be developed to reduce the risk of suicidal behavior in these groups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 5","pages":"360-371"},"PeriodicalIF":5.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipolar Disorder and Poisoning due to Medicines or Illegal Substances","authors":"Mikko Niskanen,&nbsp;Olli Kärkkäinen,&nbsp;Heidi Taipale,&nbsp;Johannes Lieslehto,&nbsp;Jari Tiihonen,&nbsp;Aleksi Hamina","doi":"10.1111/acps.70017","DOIUrl":"10.1111/acps.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals with bipolar disorder face an elevated risk of premature death, often due to external causes such as accidental injuries, self-harm, and substance-related deaths. This study aimed to investigate the incidence of severe poisonings among individuals with bipolar disorder and to examine associated demographic and clinical factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a cohort study using data from national registers in Finland, measuring hospitalizations and deaths due to poisoning by medicines or illegal substances in 1996–2018. Cox proportional hazards regression models were used to assess associations between predictor variables and poisoning outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study population comprised 60,045 individuals aged 15–65 diagnosed with bipolar disorder in 1987–2018. During the study period, 13.1% (<i>N</i> = 7872) of the population experienced at least one poisoning resulting in hospitalization or death. The age-standardized rate of hospitalizations was 50.6 (95% CI, 49.5–51.7) per 1000 person-years and of deaths 1.8 (95% CI, 1.6–2.0) per 1000 person-years. The majority of poisonings leading to hospitalization (59.1%) or death (56.6%) were intentional and caused by pharmaceuticals (hospitalizations, 76.9%; deaths, 63.6%). Additionally, psychoactive narcotics and stimulants were the cause of 26.8% of the poisoning deaths. The strongest risk factors for hospitalization were substance use disorder (adjusted hazard ratio, aHR, 2.75, 95% CI, 2.61–2.90) and a history of suicide attempt (2.70, 2.52–2.88). The risk of poisoning death was most strongly associated with substance use disorder (3.02, 2.60–3.52) and a history of suicide attempt (2.38, 1.94–2.91). Female sex was associated with a higher risk of hospitalization (1.19, 1.14–1.25), but a lower risk of death (0.72, 0.62–0.82).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Individuals with bipolar disorder face a substantial risk of poisoning by medicines or illegal substances, with notable sex differences in hospitalization and death rates. Key risk factors include substance use disorder and a history of suicide attempt.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 4","pages":"299-307"},"PeriodicalIF":5.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life Expectancy, Loss of Life Expectancy, and Lifetime Costs in Bipolar Disorder: A Nationwide Population-Based Study","authors":"Ikbal Andrian Malau,&nbsp;Ying-Ming Chiu,&nbsp;Hui-Chih Chang,&nbsp;Ya-Chu Yang,&nbsp;Jane Pei-Chen Chang,&nbsp;Christoph U. Correll,&nbsp;Vieta Eduard,&nbsp;Kuan-Pin Su","doi":"10.1111/acps.70013","DOIUrl":"10.1111/acps.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Bipolar disorder (BD) significantly affects life expectancy (LE), results in substantial loss of LE, and contributes to high medical costs, with these impacts varying by age at onset and gender. Previous studies have often overlooked the significance of age at the onset when estimating LE in individuals with BD. This study aimed to address this limitation and assess the impacts of BD on LE, loss of LE, and medical costs for BD patients categorized by age and gender in Taiwan using a new semiparametric extrapolation method over an 11-year duration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A rolling-over algorithm estimated the survival function, with lifetime risk extrapolated. LE and loss of LE were calculated by comparing BD patients to matched non-BD referents by sex, age, and diagnosis year. Lifetime medical costs were determined by multiplying average monthly expenses by survival rates. Data from Taiwan's National Health Insurance (2009–2019) identified BD patients aged 5–84 with ≥ 2 outpatient or ≥ 1 inpatient BD diagnosis. The semiparametric survival extrapolation method was validated by comparing it with the Kaplan–Meier analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results indicate that following a BD diagnosis, patients have an LE of 26.79 years, reflecting a loss of 15.08 years compared to matched referents. On average, patients with BD incurred annual medical expenses of around $2516, with costs rising with age for both sexes. The mean estimated lifetime cost for the study population was about $55,015. The extrapolation method demonstrated high accuracy, with a less than 5% relative bias.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Semiparametric extrapolation is an effective method for estimating LE, loss of LE, and lifetime costs in BD. Future work could refine semiparametric extrapolation and assess factors influencing LE loss and lifetime costs in BD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 5","pages":"350-359"},"PeriodicalIF":5.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and Clinical Characteristics of Lithium-Treated Older Adults With Bipolar Disorder: A Replication Study From the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project","authors":"Orestes V. Forlenza,&nbsp;Ni Xu,&nbsp;Peijun Chen,&nbsp;Soham Rej,&nbsp;Ariel G. Gildengers,&nbsp;Tomas Hajek,&nbsp;Martha Sajatovic,&nbsp;the GAGE-BD initiative","doi":"10.1111/acps.70016","DOIUrl":"https://doi.org/10.1111/acps.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To replicate a previous study addressing differences and similarities of older adults with bipolar disorder (OABD) treated with lithium as compared to those treated with other drugs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cross-sectional analysis of a harmonized dataset of the GAGE-BD Project, with over 2 thousand participants enrolled from two recruitment waves, with worldwide representation. Participants were allocated in two treatment groups according to the availability of information about current lithium use (Lithium, n = 754; Non-lithium, n = 1,161). We used linear regression, linear mixed and generalized linear mixed models to examine the associations between treatment groups and other variables, with emphasis on the distribution of socio-demographical and clinical variables, controlling for age, gender, and study site.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found statistical associations between lithium use and higher education level, as well as with bipolar-1 subtype, and a negative association with comorbid anxiety disorder. OABD patients treated with lithium had lower scores on depression rating scales, and better overall global cognitive and functional state. Lithium users also reported having fewer cardiovascular comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We found several potentially relevant differences in the clinical profile of OABD treated with lithium; nonetheless, the interpretation of the present results must take into account the methodological limitations inherent to the cross-sectional approach and data harmonization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 5","pages":"393-396"},"PeriodicalIF":5.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis and Dementia—Disorders of Disadvantage","authors":"Lucy Gibson,&nbsp;Christoph Mueller,&nbsp;Robert Stewart","doi":"10.1111/acps.70012","DOIUrl":"10.1111/acps.70012","url":null,"abstract":"&lt;p&gt;As any Old Age Psychiatrist will tell you, late-life affective and psychotic disorders are some of the least understood mental health conditions, particularly considering their impact and the large number of people affected. This lack of attention partly lies in the common mundane situation of overshadowing research interests. Mental health research in older adults focuses almost entirely on dementia, while research into affective and psychotic disorders focuses almost entirely on young adults. Unfortunately, lack of research translates into an impoverished evidence base, which in turn filters through to underrepresentation in healthcare policy, and this compounds the problem by reducing the likelihood of interest from research funders, impeding capacity building and perpetuating a vicious cycle of inattention which does no favours for patients or health services. Even within the field, there are inequalities in research evidence, with considerably more attention paid to late-onset syndromes than to those who may have been living with their earlier-onset condition for decades by the time they reach older age ranges.&lt;/p&gt;&lt;p&gt;However, considering late-life psychosis, overshadowing research priorities are only part of the problem, as the conditions themselves present sizeable intrinsic challenges. The social withdrawal that characterises late-onset psychosis limits the likelihood of people affected being represented in conventional recruited research samples or retained in any study involving follow-up [&lt;span&gt;1&lt;/span&gt;]. Furthermore, people with earlier-onset diagnoses are frequently out of contact with mental health services by the time they reach ‘older adult’ age ranges, so that it is difficult to identify potential participants for approaching in the first place. Conventional case control, cohort and intervention studies are therefore logistically formidable, if not wholly impractical and/or fundamentally limited by participation and/or attrition bias.&lt;/p&gt;&lt;p&gt;The growing availability of routine healthcare data for research provides important opportunities for improving the evidence base. Most national data governance frameworks permit the use of effectively anonymised healthcare information to be used for research which enables the better representation of populations who would previously have been considered ‘hard to reach’ in conventional recruited samples. This advantage is exemplified in the approach taken by Normark et al. [&lt;span&gt;2&lt;/span&gt;], described in this issue, using national data from Denmark to investigate dementia incidence in people with schizophrenia and related disorders (ICD-10 F2x) according to their age at first psychosis diagnosis or treatment. There are reasonable considerations about the required reliance on recorded diagnoses (given that both conditions may be under-diagnosed, particularly dementia, and that under-diagnosis is unlikely to be at random); however, it is difficult to see how the question could be addressed in a","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 3","pages":"153-155"},"PeriodicalIF":5.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic and Neurotransmitter Insights Into Gray Matter Volume Changes From 1 Hz rTMS in Treating Schizophrenia With Auditory Verbal Hallucinations","authors":"Yuanjun Xie,&nbsp;Chenxi Li,&nbsp;Muzhen Guan,&nbsp;Tian Zhang,&nbsp;Chaozong Ma,&nbsp;Lingling Wang,&nbsp;Xinxin Li,&nbsp;Yijun Li,&nbsp;Zhongheng Wang,&nbsp;Huaning Wang,&nbsp;Peng Fang","doi":"10.1111/acps.70014","DOIUrl":"10.1111/acps.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Auditory verbal hallucinations (AVH) are prominent positive symptoms of schizophrenia that frequently prove resistant to conventional antipsychotic treatments. Low-frequency repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for AVH; however, the underlying neurobiological mechanisms mediating its efficacy remain incompletely understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, schizophrenia patients with AVH were randomly assigned to either an active stimulation group or a sham control group. The active stimulation group received 1 Hz rTMS targeting the left temporoparietal junction (TPJ), while the sham group underwent an identical procedure without actual stimulation. Structural MRI scans were conducted before and after treatment to evaluate changes in gray matter volume (GMV). Further analyses examined associations between GMV changes and both gene expression profiles and neurotransmitter receptor densities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Active rTMS stimulation resulted in a significant reduction in AVH symptoms and was associated with increased GMV in specific cortical regions related to sensory and cognitive processing. These structural changes correlated with gene sets enriched in neuroplasticity-related pathways, such as cell morphogenesis, chromatin remodeling, and vesicle cytoskeletal trafficking. Notable changes were also observed in neurotransmitter receptor densities, particularly for serotonin (5HT1a), dopamine (D1), and glutamate (mGluR5) receptors. Multiple linear regression analysis identified specific hub gene expressions, such as ANK1, and patterns of neurotransmitter density, especially mGluR5, as significant predictors of GMV changes following rTMS stimulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Low-frequency rTMS induced GMV changes, coupled with alterations in gene expression and neurotransmitter receptor densities, contribute to symptom alleviation in schizophrenia patients with AVH. These findings support rTMS as a promising intervention for targeting the neurobiological substrates underlying AVH in schizophrenia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"152 5","pages":"372-392"},"PeriodicalIF":5.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships of Cognitive Function With Subsequent Device-Measured Physical Activity and Sedentary Time in Healthy Individuals and Those With Bipolar Disorder: Findings From the UK Biobank.","authors":"Elysha Ringin, David W Dunstan, Denny Meyer, Roger S McIntyre, Neville Owen, Michael Berk, Susan L Rossell, Mats Hallgren, Tamsyn E Van Rheenen","doi":"10.1111/acps.70011","DOIUrl":"https://doi.org/10.1111/acps.70011","url":null,"abstract":"<p><strong>Background: </strong>In bipolar disorder (BD), physical inactivity and sedentary behaviour are prevalent and have been linked to BD's cognitive symptoms, although the directionality of these links is not clear. This proof-of-concept study examined whether cognitive function during mid- and later-life was prospectively related to physical activity and sedentary time, and whether the association differed in presence or extent between those with BD and healthy controls.</p><p><strong>Methods: </strong>Relevant UK Biobank data were available for 646 BD participants and 18,041 psychiatrically healthy controls, aged 40-69 years at baseline. Cognition was assessed during a baseline assessment, and wrist-worn accelerometry data were collected at a follow-up assessment 2.8-6.6 years later. Regression analyses examined prospective relationships of global cognition, diagnostic group, and their interaction, with physical activity (total, light, and moderate to vigorous) and sedentary time.</p><p><strong>Results: </strong>Baseline cognitive function was inversely associated with light physical activity (coeff. = -5.64, 95% CI: -6.30 to -4.98) and positively associated with sedentary time (coeff. = 5.17, 95% CI: 4.48-5.86) and moderate-to-vigorous physical activity (coeff. = 0.48, 95% CI: 0.28-0.68) at follow-up. Observed effect sizes were small but significant. In general, associations were not moderated by age or diagnostic group.</p><p><strong>Conclusions: </strong>The current study provides preliminary evidence that cognitive function may influence subsequent physical activity and sedentary time similarly in those with BD and healthy controls; however, further research is needed to confirm and further explore this findings.</p>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}