Hepatology最新文献

{"title":"The dynamic duo: How tumor-associated macrophages and tumor cells team up in cholangiocarcinoma.","authors":"Binbin Li,Sumera I Ilyas","doi":"10.1097/hep.0000000000001378","DOIUrl":"https://doi.org/10.1097/hep.0000000000001378","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"40 1","pages":"1-2"},"PeriodicalIF":13.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not so subclinical: Is early thyroid disease an untapped avenue to protect children from MASLD?","authors":"George Marek","doi":"10.1097/hep.0000000000001379","DOIUrl":"https://doi.org/10.1097/hep.0000000000001379","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"6 1","pages":"5-6"},"PeriodicalIF":13.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two heads are better than one: The synergy of carvedilol and simvastatin.","authors":"Prabhat Kumar,Juan Pablo Arab","doi":"10.1097/hep.0000000000001380","DOIUrl":"https://doi.org/10.1097/hep.0000000000001380","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"156 1","pages":"3-4"},"PeriodicalIF":13.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genes that fit just right: Unzipping the genome of fatty liver disease.","authors":"Jack W Sample","doi":"10.1097/hep.0000000000001377","DOIUrl":"https://doi.org/10.1097/hep.0000000000001377","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"14 1","pages":"7-8"},"PeriodicalIF":13.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Considerations on the specific role of LHX2 in the process of hepatic stellate cells regulating hepatocyte function","authors":"Jiawang Tao, Jie Wang","doi":"10.1097/hep.0000000000001435","DOIUrl":"https://doi.org/10.1097/hep.0000000000001435","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"13 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building hepatitis B virus gene transcription from the bottom up","authors":"Andoni Gómez-Moreno, Daniel Bradley, Alexander Ploss","doi":"10.1097/hep.0000000000001437","DOIUrl":"https://doi.org/10.1097/hep.0000000000001437","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"13 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor: Considerations on the specific role of LHX2 in the process of hepatic stellate cells regulating hepatocyte function","authors":"Jiaping Ni, Dongqing Zhai, Jintong Li, Binghua Li, Weiwei Hu","doi":"10.1097/hep.0000000000001434","DOIUrl":"https://doi.org/10.1097/hep.0000000000001434","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"6 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiangiogenic therapy combined with immune checkpoint blockade mediates CCR7+CD8+ T-cell entry into HCC through high endothelial venules","authors":"Lu Tang, Yingwen Hou, Tian Di, Xiuxia Lu, Jiarui Huang, Ling Gu, Yueyang Yu, Lili Liu, Jiliang Qiu, Lian Li, Limin Zheng, Lin Tian, Zhimei Huang, Yiquan Jiang, Jinhua Huang, Xue Han","doi":"10.1097/hep.0000000000001426","DOIUrl":"https://doi.org/10.1097/hep.0000000000001426","url":null,"abstract":"Background &amp; Aims: Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality in China. Anti-angiogenic drugs (AADs) plus immune checkpoint blockade (ICB) combination therapy shows considerable promise for HCC; however, its efficacy is hampered by immunosuppression within the tumor microenvironment. High endothelial venules (HEVs) facilitate lymphocyte migration and tumor infiltration. The aim was to study the formation, functional mechanisms, and clinical relevance of HEVs in the treatment of HCC with combination therapy. Approach &amp; Results: Single-nucleus RNA sequencing, flow cytometry, and immunohistochemistry revealed increased HEV expression and higher CD3⁺ T-cell infiltration in HCC tissue after combination AAD and ICB therapy. Multiplex immunohistochemistry and spatial analysis demonstrated that CCR7⁺CD8⁺ T cells were spatially associated with HEVs. Pseudotime analysis of human T cells and treatment of Hepa1-6 orthotopic liver tumor mouse models with CCR7<jats:sup>+</jats:sup>CD8<jats:sup>+</jats:sup> T-cell transfusions were used to show that CCR7<jats:sup>+</jats:sup>CD8<jats:sup>+</jats:sup> T cells can differentiate into cytotoxic effector T cells. The same models demonstrated that combination therapy activated VEGFC and non-canonical NF-κB pathways, promoting HEV formation. Kaplan-Meier analysis revealed that high HEV density correlated with improved clinical response and prolonged survival. Conclusions: HEVs are pivotal in modulating immune activity within the HCC tumor microenvironment. Targeting the VEGFC–NF-κB (non- canonical)–HEV axis could be a promising therapeutic strategy to enhance antitumor immunity and improve outcomes in patients with HCC who are receiving combination AAD plus ICB therapy.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"37 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries’ framework for digital twin advancement","authors":"Guido Carpino, Diletta Overi, Rocio IR. Macias, Vincenzo Cardinale, Laura Izquierdo-Sanchez, Pilar Acedo, Marco Rengo, Michail Doukas, Timothy J Kendall, Julien Calderaro, Lara R Heij, Konrad Reichel, Stefano Leone, Paolo Onori, Barbara Franceschini, Cristiana Soldani, Luca Di Tommaso, Pedro M Rodrigues, Jérémy Augustin, Raffaele Brustia, Guido Torzilli, Manuela Martin-Izquierdo, Jose M Hernández-Bayo, Diego Bueno-Sacristan, Ezio Lanza, Andres Garcia-Sampedro, Alberto Quaglia, Francesco Ardito, Agostino Maria De Rose, Felice Giuliante, Elio Damato, Valeria Panebianco, Bas Groot Koerkamp, Stephen P Pereira, Gian Luca Grazi, Domenico Alvaro, Ana Lleo, Jesus M Banales, Eugenio Gaudio","doi":"10.1097/hep.0000000000001425","DOIUrl":"https://doi.org/10.1097/hep.0000000000001425","url":null,"abstract":"Background &amp; Aims: Cholangiocarcinoma (CCA) displays remarkable anatomical and histological heterogeneity. Besides diagnosis confirmation, histology currently does not have a major role in the management of CCA. We aimed to study the clinical relevance of histological heterogeneity of CCA and putative tissue biomarkers by creating a multicentric digitalized European CCA Histology Registry. Approach &amp; Results: Nine referral centers, participating in the International Cholangiocarcinoma clinical registry, shared samples and data from 293 patients. Histological and immunohistochemistry stains (n=10) were performed. Computed tomography (CT) scans (n=112 cases) were analyzed by morphological and radiomics techniques. A selection of cases (n=18) was processed for spatial transcriptomics analysis. No significant differences in 5-year overall survival (OS) were found in perihilar CCA vs intrahepatic (i) CCA, and in Small Bile Duct (SBD) vs Large Bile Duct (LBD) iCCA. When cases were classified by periodic acid of Schiff (PAS) positivity (mucin content), PAS<jats:sup>HIGH</jats:sup> LBD iCCA showed a significantly worse 5-year OS compared to PAS<jats:sup>LOW</jats:sup> iCCA. Multivariate Cox regression identified PAS<jats:sup>HIGH</jats:sup> LBD iCCA phenotype as an independent predictor of a worse OS. PAS<jats:sup>HIGH</jats:sup> LBD iCCA subtype showed specific molecular characteristics at spatial transcriptomics and immunohistochemistry; CT scans and serology could distinguish PAS<jats:sup>HIGH</jats:sup> LBD iCCA phenotype with excellent accuracy. Conclusion: Our data underline the importance of identifying morphological subclasses with a significant prevalence in CCA as a tool for risk stratification and prognosis. The European CCA Histology Registry represents a valuable platform for integrating digital pathology with clinical, radiological, and molecular information as a framework for digital twin advancement.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"102 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Biopsy-Free Endpoints in MASH Trials: A Comparative Look at MASHResInd and FAST”","authors":"Federico Ravaioli","doi":"10.1097/hep.0000000000001421","DOIUrl":"https://doi.org/10.1097/hep.0000000000001421","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"8 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}