Hepatology最新文献

{"title":"Minor players, major signals: Unveiling the systemic and gut-localized impact of microbial amidated bile acids in hepatopancreatobiliary disease.","authors":"Giselle Adriana Abruzzese,Maria Luz Martínez-Chantar","doi":"10.1097/hep.0000000000001473","DOIUrl":"https://doi.org/10.1097/hep.0000000000001473","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"11 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning's crystal ball: Predicting HCC surgery success with multimodal imaging.","authors":"Ankit Chodha","doi":"10.1097/hep.0000000000001410","DOIUrl":"https://doi.org/10.1097/hep.0000000000001410","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"10 1","pages":"275-276"},"PeriodicalIF":13.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D-SWE in MASLD: Should we utilize it more with these new cutoffs?","authors":"Prowpanga Udompap","doi":"10.1097/hep.0000000000001408","DOIUrl":"https://doi.org/10.1097/hep.0000000000001408","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"1 1","pages":"281-282"},"PeriodicalIF":13.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better late than resectable: Combination therapy finds its moment.","authors":"Sarah Khan","doi":"10.1097/hep.0000000000001409","DOIUrl":"https://doi.org/10.1097/hep.0000000000001409","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"52 1","pages":"277-278"},"PeriodicalIF":13.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding liver risk: A deep dive into the Baveno VII \"Rule-of-Five\" criteria.","authors":"Kaanthi Rama,Juan Pablo Arab","doi":"10.1097/hep.0000000000001411","DOIUrl":"https://doi.org/10.1097/hep.0000000000001411","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"14 1","pages":"279-280"},"PeriodicalIF":13.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Considerations on the diagnostic accuracy and applicability of MASHResInd in MASH Resolution.","authors":"Rohit Loomba,Peter Chen-Yang Nikhil Daniel,Daniel Q Huang","doi":"10.1097/hep.0000000000001468","DOIUrl":"https://doi.org/10.1097/hep.0000000000001468","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"207 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the metabolic thread: Type 2 diabetes and fibrosis in chronic hepatitis B with steatosis.","authors":"Won-Mook Choi,Wai-Kay Seto","doi":"10.1097/hep.0000000000001469","DOIUrl":"https://doi.org/10.1097/hep.0000000000001469","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"55 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretreatment serum bile acid composition and predictability of subsequent response to odevixibat in patients with bile salt export pump (BSEP) deficiency","authors":"Mark Nomden, Folkert Kuipers, Willem S. Lexmond, Tao Gu, Velichka Valcheva, Erik Lindström, Henkjan J. Verkade","doi":"10.1097/hep.0000000000001430","DOIUrl":"https://doi.org/10.1097/hep.0000000000001430","url":null,"abstract":"Background &amp; Aims: Bile salt export pump (BSEP) deficiency, or progressive familial intrahepatic cholestasis type 2, is a genetic liver disease characterized by defective biliary bile acid secretion. Odevixibat, an ileal bile acid transporter inhibitor (IBATi), impairs intestinal reabsorption of conjugated bile acids, reducing serum bile acid (sBA) concentration in some patients with BSEP deficiency. We evaluated association of pretreatment sBA levels and composition, and subsequent response to odevixibat in patients with BSEP deficiency to improve our understanding of the mechanism. Approach &amp; Results: In this blinded <jats:italic toggle=\"yes\">post hoc</jats:italic> analysis, pretreatment sBAs from 41 odevixibat-treated patients with BSEP deficiency who participated in PEDFIC were analyzed using liquid chromatography-tandem mass spectrometry. Patients were divided into sBA responders (Rs) and non-responders (NRs). Association of pretreatment individual sBAs with subsequent response was evaluated and receiver operating characteristic (ROC) curves were constructed to identify discriminating cutoff values. Rs had higher pretreatment percentages of unconjugated cholic acid (CA; area under the ROC curve [AUC]: 0.70 [95% CI: 0.52–0.87; <jats:italic toggle=\"yes\">P</jats:italic>=0.03]), unconjugated chenodeoxycholic acid (CDCA; AUC: 0.73 [0.56–0.90]; <jats:italic toggle=\"yes\">P</jats:italic>=0.01), and concentration of CA + CDCA (AUC: 0.76 [0.61–0.92]; <jats:italic toggle=\"yes\">P</jats:italic>=0.001). When ≥1 of 3 cutoffs were reached, 36/41 (87.8%) patients with BSEP deficiency were correctly classified as subsequent Rs (17/19; sensitivity: 89.5%) or NRs (19/22; specificity: 86.4%). Conclusions: Higher pretreatment serum levels of unconjugated CA and CDCA are associated with subsequent response to odevixibat in patients with BSEP deficiency. Response to odevixibat may be related to residual biliary bile acid secretion capacity in patients with BSEP deficiency.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"109 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Clonal hematopoiesis in MASLD-associated HCC: Variant burden may matter more than presence","authors":"Eva Katharina Messer, Janett Fischer, Anne Weigert, Klaus H. Metzeler, Thomas Berg","doi":"10.1097/hep.0000000000001466","DOIUrl":"https://doi.org/10.1097/hep.0000000000001466","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"693 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary microbiome and serum metabolomics add to clinical biomarkers to predict 6-month hospitalizations in a multi-center cirrhosis outpatient cohort","authors":"Jasmohan S. Bajaj, K Rajender Reddy, Puneeta Tandon, Jennifer C. Lai, Jacqueline G. O’Leary, Florence Wong, Guadalupe Garcia-Tsao, Hugo E. Vargas, Patrick S. Kamath, Scott W. Biggins, Phillip Vutien, Jawaid Shaw, Ana Teresa Limon Miro, Chinmay Bera, Joseph P. McGinley, Masoumeh Sikaroodi, Brian J. Bush, Leroy R. Thacker, Patrick M. Gillevet","doi":"10.1097/hep.0000000000001462","DOIUrl":"https://doi.org/10.1097/hep.0000000000001462","url":null,"abstract":"Background &amp; Aims: Prognosticating outcomes such as hospitalizations in cirrhosis outpatients is challenging, especially with changing etiologies and demographics. Aim: Determine impact of multi-omic strategies on outcome prediction. Approach &amp; Results: NACSELD3 enrolls cirrhosis outpatients with controlled/eradicated etiologies from 10 centers and follows them systematically. At baseline, clinical/demographic and cirrhosis details were recorded and saliva and serum samples were collected for microbiome and metabolome analysis respectively. Multi-omic bioinformatic studies to determine interaction of microbiota and metabolites with clinical prediction of 6-month hospitalizations were performed. 565 patients (60.2 years, 68% men, 35% alcohol, 33% MASH, 21%, eradicated HCV with MELD3.0 12) were enrolled. 163 (29%) required 6-month hospitalizations; most (75%) were liver-related. Those hospitalized had worse cirrhosis severity, co-morbidity indices, but similar demographics and oral health variables. Salivary microbiome alpha-diversity was lower (1.96±0.48 vs. 2.09±0.45, <jats:italic toggle=\"yes\">p</jats:italic>=0.018) with greater pathobionts (<jats:italic toggle=\"yes\">Streptococcus</jats:italic>, <jats:italic toggle=\"yes\">Treponema, Enterococcaceae)</jats:italic> and lower commensal genera (<jats:italic toggle=\"yes\">Veillonella, Prevotella, Haemophilus</jats:italic>, <jats:italic toggle=\"yes\">Lachnospiraceae</jats:italic> spp) at baseline. Serum metabolomics showed significant separation at baseline between hospitalized/not patients using supervised analyses with microbial-origin (phenyllactate, secondary bile acids, indoles), choline moieties, and polyamine/GABA (3-ureidopropionate/spermidine) metabolites being most prominent. Area-under-the curve using random forest for clinical, microbial, and metabolomic variables were higher than that of these individually. Latent factor analysis showed clinical variables (MELD3.0, hemoglobin and albumin) with the greatest impact followed by salivary microbiota and then serum microbiome for hospitalization prediction. Conclusion: In a multi-center North American outpatient cirrhosis cohort with controlled etiologies, serum metabolomics and salivary microbiome add to clinical variables to prognosticate 6-month hospitalization.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"10 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}