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From guidance to GRADE guidelines and EXPOs: Advancing the future of AASLD clinical recommendations 从指南到GRADE指南和expo：推进AASLD临床建议的未来
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-07 DOI: 10.1097/hep.0000000000001824
Elizabeth C. Verna,Jennifer C. Price,Cynthia Levy
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引用次数: 0
The Liver Meeting: 2026 Author Index 肝脏会议：2026作者索引
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-05 DOI: 10.1097/hep.0000000000001843
{"title":"The Liver Meeting: 2026 Author Index","authors":"","doi":"10.1097/hep.0000000000001843","DOIUrl":"https://doi.org/10.1097/hep.0000000000001843","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"23 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Liver Meeting: 2026 Plenary and Parallel Sessions: 0001-0281 肝脏会议：2026全体会议和平行会议：0001-0281
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-05 DOI: 10.1097/hep.0000000000001842
{"title":"The Liver Meeting: 2026 Plenary and Parallel Sessions: 0001-0281","authors":"","doi":"10.1097/hep.0000000000001842","DOIUrl":"https://doi.org/10.1097/hep.0000000000001842","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"35 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Liver Meeting: 2026 Sunday, Nov 8 Posters: 4001-4612 肝脏会议：2026周日，11月8日海报：4001-4612
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-05 DOI: 10.1097/01.hep.0001249264.98680.83
{"title":"The Liver Meeting: 2026 Sunday, Nov 8 Posters: 4001-4612","authors":"","doi":"10.1097/01.hep.0001249264.98680.83","DOIUrl":"https://doi.org/10.1097/01.hep.0001249264.98680.83","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"56 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Liver Meeting: 2026 Thursday, Nov 5 Posters: 1001-1694 肝脏会议：2026年11月5日星期四海报：1001-1694
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-05 DOI: 10.1097/01.hep.0001249252.53649.9f
{"title":"The Liver Meeting: 2026 Thursday, Nov 5 Posters: 1001-1694","authors":"","doi":"10.1097/01.hep.0001249252.53649.9f","DOIUrl":"https://doi.org/10.1097/01.hep.0001249252.53649.9f","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"14 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Liver Meeting: 2026 Subject Categories 肝脏会议：2026个学科类别
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-05 DOI: 10.1097/hep.0000000000001844
{"title":"The Liver Meeting: 2026 Subject Categories","authors":"","doi":"10.1097/hep.0000000000001844","DOIUrl":"https://doi.org/10.1097/hep.0000000000001844","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"40 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Liver Meeting: 2026 Saturday, Nov 7 Posters: 3001-3598 肝脏会议：2026星期六，11月7日海报：3001-3598
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-05 DOI: 10.1097/01.hep.0001249260.22455.51
{"title":"The Liver Meeting: 2026 Saturday, Nov 7 Posters: 3001-3598","authors":"","doi":"10.1097/01.hep.0001249260.22455.51","DOIUrl":"https://doi.org/10.1097/01.hep.0001249260.22455.51","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"9 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Liver Meeting: 2026 Friday, Nov 6 Posters: 2002-2697 肝脏会议：2026年11月6日星期五海报：2002-2697
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-05 DOI: 10.1097/01.hep.0001249256.48215.72
{"title":"The Liver Meeting: 2026 Friday, Nov 6 Posters: 2002-2697","authors":"","doi":"10.1097/01.hep.0001249256.48215.72","DOIUrl":"https://doi.org/10.1097/01.hep.0001249256.48215.72","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"225 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of an 8-week bemnifosbuvir and ruzasvir regimen in chronic hepatitis C: Results from a Phase 2 study 贝尼非布韦联合鲁扎韦8周治疗慢性丙型肝炎的疗效和安全性：来自一项2期研究的结果
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-02 DOI: 10.1097/hep.0000000000001871
Alina Jucov, Brian Conway, Jordan J. Feld, Saeed Hamid, Elena Ermacicova, Laura Iliescu, Bruce Belanger, Shannan Lynch, Qi Huang, Xiao-Jian Zhou, Arantxa Horga, Eric Lawitz
{"title":"Efficacy and safety of an 8-week bemnifosbuvir and ruzasvir regimen in chronic hepatitis C: Results from a Phase 2 study","authors":"Alina Jucov, Brian Conway, Jordan J. Feld, Saeed Hamid, Elena Ermacicova, Laura Iliescu, Bruce Belanger, Shannan Lynch, Qi Huang, Xiao-Jian Zhou, Arantxa Horga, Eric Lawitz","doi":"10.1097/hep.0000000000001871","DOIUrl":"https://doi.org/10.1097/hep.0000000000001871","url":null,"abstract":"Background & Aims: Bemnifosbuvir and ruzasvir are potent pan-genotypic inhibitors of the hepatitis C virus (HCV) NS5B polymerase and NS5A protein, respectively. This single-arm, Phase 2 study evaluated the efficacy and safety of bemnifosbuvir and ruzasvir in treatment-naïve patients with chronic HCV infection of any genotype, with or without compensated cirrhosis. Approach & Results: Patients received bemnifosbuvir 550 mg and ruzasvir 180 mg once daily for 8 weeks (intention-to-treat [ITT] population). The primary efficacy endpoint was the proportion of patients achieving sustained virologic response at 12 weeks post treatment (SVR12) in the Pharmacokinetic and Pill Compliant Per-Protocol (PK/PC-PP) population. Secondary efficacy endpoints included SVR12 in the Efficacy Evaluable Per-Protocol (EE-PP; those with outcomes regardless of study drug adherence) and safety (all dosed) populations, virologic failure, and SVR24. Of the 275 patients enrolled and who received treatment with bemnifosbuvir and ruzasvir, 13% had compensated cirrhosis and 27% had NS5A resistance-associated substitutions (RASs) at baseline. SVR12 was 90% (248/275; 95% CI: 86–93%) in the ITT population, 98% (210/215; 95% CI: 95–99%) in the PK/PC-PP population, and 95% (245/259; 95% CI: 91–97%) in the EE-PP population. Five patients in the PK/PC-PP population experienced virologic failure (post-treatment relapse). No drug-related serious adverse events or premature treatment discontinuations due to drug-related adverse events were reported. Conclusions: An 8-week treatment with bemnifosbuvir and ruzasvir resulted in high rates of SVR12 across genotypes, regardless of the presence or absence of baseline RASs, and was well tolerated among treatment-naïve HCV patients.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"150 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatogenesis through interspecies chimerism – An immunological path distinct from xenotransplantation 通过种间嵌合的肝发生-一种不同于异种移植的免疫途径
IF 13.5 1区 医学
Hepatology Pub Date : 2026-10-02 DOI: 10.1097/hep.0000000000001880
Joseph Sushil Rao, Anala Shetty, Sabarinathan Ramachandran, Clifford J. Steer
{"title":"Hepatogenesis through interspecies chimerism – An immunological path distinct from xenotransplantation","authors":"Joseph Sushil Rao, Anala Shetty, Sabarinathan Ramachandran, Clifford J. Steer","doi":"10.1097/hep.0000000000001880","DOIUrl":"https://doi.org/10.1097/hep.0000000000001880","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"1 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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