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Reply: Diabetes and fibrosis: Parallel risks or overlap? 糖尿病和纤维化：平行风险还是重叠风险？
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-17 DOI: 10.1097/hep.0000000000001531
Binu V John,Dustin Bastaich,Bassam Dahman,
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引用次数: 0
Reply: Insights into immune-mediated adverse events and survival outcomes: Lessons from HIMALAYA 答复：免疫介导的不良事件和生存结果的见解：来自喜马拉雅的经验教训
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-17 DOI: 10.1097/hep.0000000000001527
Ghassan K. Abou-Alfa, George Lau
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引用次数: 0
Letter to the editor: Technical considerations in the development of a multimodal deep learning model for predicting hepatocellular carcinoma outcomes 致编辑的信：开发用于预测肝细胞癌预后的多模态深度学习模型的技术考虑
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-17 DOI: 10.1097/hep.0000000000001534
Zheng Pan
{"title":"Letter to the editor: Technical considerations in the development of a multimodal deep learning model for predicting hepatocellular carcinoma outcomes","authors":"Zheng Pan","doi":"10.1097/hep.0000000000001534","DOIUrl":"https://doi.org/10.1097/hep.0000000000001534","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"127 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prognostic model in patients with alcohol-related cirrhosis does exist 酒精相关性肝硬化患者的预后模型确实存在
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-17 DOI: 10.1097/hep.0000000000001532
Pierre Deltenre, Astrid Marot, Jean Henrion
{"title":"A prognostic model in patients with alcohol-related cirrhosis does exist","authors":"Pierre Deltenre, Astrid Marot, Jean Henrion","doi":"10.1097/hep.0000000000001532","DOIUrl":"https://doi.org/10.1097/hep.0000000000001532","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"6 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: Diabetes and fibrosis: Parallel risks or overlap? 致编辑：糖尿病和纤维化：平行风险还是重叠风险？
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-17 DOI: 10.1097/hep.0000000000001528
Shenglong Li, Longfei You
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引用次数: 0
IL1β Signaling Mediates the Interaction Between Hepatitis B and C Viruses. il - 1β信号介导乙型和丙型肝炎病毒相互作用
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-12 DOI: 10.1097/hep.0000000000001525
Fan Zhang,Yuanyuan Zhao,Lu Bian,Xinjia Wang,Eun Hee Ha,Lei Wang,Zhuoying Feng,Egan Sanchez,Andrew C Kwong,Kyle O'Shaughnessy,Weibo Chen,Shuyang Chen,Suan-Sin Foo,Weiqiang Chen,Liqun Ning,Yingpu Yu,Yujie Zhang,Viet Loan Dao Thi,Jianjun Wu,Xianfang Wu
{"title":"IL1β Signaling Mediates the Interaction Between Hepatitis B and C Viruses.","authors":"Fan Zhang,Yuanyuan Zhao,Lu Bian,Xinjia Wang,Eun Hee Ha,Lei Wang,Zhuoying Feng,Egan Sanchez,Andrew C Kwong,Kyle O'Shaughnessy,Weibo Chen,Shuyang Chen,Suan-Sin Foo,Weiqiang Chen,Liqun Ning,Yingpu Yu,Yujie Zhang,Viet Loan Dao Thi,Jianjun Wu,Xianfang Wu","doi":"10.1097/hep.0000000000001525","DOIUrl":"https://doi.org/10.1097/hep.0000000000001525","url":null,"abstract":"BACKGROUND AND AIMSHepatitis B virus (HBV) and hepatitis C virus (HCV) share transmission routes and often coinfect the liver, leading to accelerated liver disease progression. In the era of direct-acting antivirals (DAAs) for HCV, the clinical impact of coinfection is further complicated by reports of HBV reactivation following HCV cure. While HCV-induced interferon (IFN) responses are known to suppress HBV, the underlying mechanisms remain incompletely understood. This study aimed to investigate how HCV modulates HBV infection in the setting of coinfection and to identify strategies to prevent HBV reactivation post-HCV clearance.APPROACH AND RESULTSWe utilized a multicellular liver culture model composed of human-induced pluripotent stem cell (hiPSC)-derived hepatocytes, hepatic stellate cells, and macrophages, which supports productive HBV and HCV infection and recapitulates clinical coinfection dynamics. We found that IL1β derived from HCV-activated macrophage suppresses HBV replication independent of IFN signaling. Mechanistically, IL1β downregulated the HBV receptor SLC10A1 in hepatocytes via induction of a truncated C/EBPβ isoform that negatively regulates the full-length variant. Concurrently, IL1β induced ISG20 expression through USF1 phosphorylation, further inhibiting HBV replication. A combination treatment of DAAs and an HBV entry inhibitor effectively prevented HBV reactivation in the model.CONCLUSIONSOur findings reveal a macrophage-derived, IFN-independent mechanism by which HCV suppresses HBV infection, mediated through IL1β. These insights highlight the complex crosstalk between hepatotropic viruses during coinfection and suggest that targeting IL1β-regulated pathways may offer therapeutic potential to prevent HBV reactivation in DAA-treated patients.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"41 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: Re-examining neoadjuvant chemoradiation plus transplantation versus liver resection for de novo perihilar cholangiocarcinoma. 回复：重新检查新辅助放化疗加肝移植与肝切除治疗新发肝门周围胆管癌。
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-10 DOI: 10.1097/hep.0000000000001521
Yawen Dong,Zhihao Li,Gregory J Gores,Julie K Heimbach,Rory L Smoot,Timucin Taner,Patrick P Starlinger
{"title":"Reply: Re-examining neoadjuvant chemoradiation plus transplantation versus liver resection for de novo perihilar cholangiocarcinoma.","authors":"Yawen Dong,Zhihao Li,Gregory J Gores,Julie K Heimbach,Rory L Smoot,Timucin Taner,Patrick P Starlinger","doi":"10.1097/hep.0000000000001521","DOIUrl":"https://doi.org/10.1097/hep.0000000000001521","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"27 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: Assessing HCC risk in HBV indeterminate phase. 答复：评估HBV不确定期的HCC风险。
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-10 DOI: 10.1097/hep.0000000000001522
Vicki Wing-Ki Hui,Grace Lai-Hung Wong,Terry Cheuk-Fung Yip
{"title":"Reply: Assessing HCC risk in HBV indeterminate phase.","authors":"Vicki Wing-Ki Hui,Grace Lai-Hung Wong,Terry Cheuk-Fung Yip","doi":"10.1097/hep.0000000000001522","DOIUrl":"https://doi.org/10.1097/hep.0000000000001522","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"103 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: Re-examining neoadjuvant chemoradiation plus transplantation versus liver resection for de novo perihilar cholangiocarcinoma. 给编辑的信：重新检查新辅助放化疗加移植与肝切除治疗新发肝门周围胆管癌。
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-10 DOI: 10.1097/hep.0000000000001519
Yao Li,Xichen Fan,Xiaoou Xu
{"title":"Letter to the editor: Re-examining neoadjuvant chemoradiation plus transplantation versus liver resection for de novo perihilar cholangiocarcinoma.","authors":"Yao Li,Xichen Fan,Xiaoou Xu","doi":"10.1097/hep.0000000000001519","DOIUrl":"https://doi.org/10.1097/hep.0000000000001519","url":null,"abstract":"","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"35 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles. 载聚ic脂质纳米颗粒对原发性和转移性肝肿瘤的有效抑制。
IF 13.5 1区 医学
Hepatology Pub Date : 2025-09-10 DOI: 10.1097/hep.0000000000001514
Yingluo Liu,Xinyi Wang,Nishta Krishnan,Timothy Hsiao,Yichun Ji,Kota Kaneko,Marcos G Teneche,Peter D Adams,Elina Zuniga,Susan M Kaech,Liangfang Zhang,Gen-Sheng Feng
{"title":"Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles.","authors":"Yingluo Liu,Xinyi Wang,Nishta Krishnan,Timothy Hsiao,Yichun Ji,Kota Kaneko,Marcos G Teneche,Peter D Adams,Elina Zuniga,Susan M Kaech,Liangfang Zhang,Gen-Sheng Feng","doi":"10.1097/hep.0000000000001514","DOIUrl":"https://doi.org/10.1097/hep.0000000000001514","url":null,"abstract":"BACKGROUND AND AIMSSo far, there is no effective mechanism-based therapeutic agent tailored for liver tumors. Immune checkpoint inhibitors (ICIs) have demonstrated limited efficacy in liver cancer, often associated with severe adverse effects. Although poly-inosinic:cytidylic acid (polyIC) has shown an adjuvant effect when combined with anti-PD-L1 antibody (αPD-L1) in treating liver tumors in animal models, its systemic toxicity limits its clinical utility. To address this challenge, the original goal of this study was to develop a liver-targeted strategy to minimize toxicity.METHODS AND RESULTSWe constructed lipid nanoparticles (LNPs) encapsulating polyIC for selective delivery to the liver and evaluated the tumor-suppressive effects of polyIC-LNPs, free polyIC, and/or αPD-L1 in multiple murine liver tumor models. We also analyzed changes in the hepatic immune microenvironment using single-cell RNA sequencing and flow cytometry. Surprisingly, polyIC-LNPs alone robustly suppressed both primary and metastatic liver tumors, independent of αPD-L1. Even a single dose of polyIC-LNPs was sufficient to control liver tumor progression. Primarily taken up by hepatocytes, polyIC-LNPs induced sustained type I interferon signaling, reshaped the hepatic immune landscape, and promoted CD8⁺ T cell infiltration and activation by enhancing the maturation of conventional dendritic cells (cDC1), ultimately resulting in a potent anti-tumor response.CONCLUSIONContrary to our original goal, we unexpectedly found that polyIC-LNPs function as an efficacious monotherapy tailored for liver cancer, capable of coordinately modulating antitumor immunity. This novel approach eliminates the need for ICIs, thereby addressing key limitations of current immunotherapies.","PeriodicalId":177,"journal":{"name":"Hepatology","volume":"14 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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