肝癌的环境危险因素

IF 12.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Hepatology Pub Date : 2025-07-07 DOI:10.1097/hep.0000000000001463

Katherine A. McGlynn, Cody Z. Watling, Brenda Y. Hernandez, John D. Groopman

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引用次数: 0

摘要

在《2021年致癌物报告》中，美国国家毒理学计划列出了63种已知的人类致癌物。虽然列出的许多物质都是环境因素，但只有黄曲霉毒素和氯乙烯这两种物质与肝癌有明确的联系。众所周知，黄曲霉毒素会增加患肝细胞癌（HCC）的风险，而氯乙烯则会导致肝脏血管肉瘤。已经研究了若干其他环境因素与肝癌的关系，如空气污染、全氟烷基和多氟烷基物质、蓝藻、农药、马兜铃酸、多环芳烃、石棉、砷和有机溶剂，但有关这些接触的证据有限。这篇综述文章的目的是检查目前已知的环境风险因素和肝癌，并建议哪些因素应该优先进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Environmental Risk Factors for Liver Cancer

In the 2021 Report on Carcinogens, the National Toxicology Program of the United States listed 63 known human carcinogens. While many of the listed agents are environmental factors, only two, aflatoxin and vinyl chloride, have been definitely linked to types of liver cancer. Aflatoxin is well known to increase the risk of hepatocellular carcinoma (HCC), while vinyl chloride is a cause of angiosarcoma of the liver. A number of other environmental factors have been studied for an association with liver cancers, such as air pollution, per- and polyfluoroalkyl substances, cyanobacteria, pesticides, aristolochic acid, polycyclic aromatic hydrocarbons, asbestos, arsenic, and organic solvents, however limited evidence exists for these exposures. It is the goal of this review article to examine what is currently known about environmental risk factors and liver cancer and suggest which ones should have the highest priority for further research.

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来源期刊

Hepatology 医学-胃肠肝病学

CiteScore

27.50

自引率

3.70%

发文量

609

审稿时长

1 months

期刊介绍： HEPATOLOGY is recognized as the leading publication in the field of liver disease. It features original, peer-reviewed articles covering various aspects of liver structure, function, and disease. The journal's distinguished Editorial Board carefully selects the best articles each month, focusing on topics including immunology, chronic hepatitis, viral hepatitis, cirrhosis, genetic and metabolic liver diseases, liver cancer, and drug metabolism.