Acta Neuropathologica最新文献

{"title":"Correction: CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease","authors":"Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Andrea L. Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner S. Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blennow","doi":"10.1007/s00401-025-02877-4","DOIUrl":"10.1007/s00401-025-02877-4","url":null,"abstract":"","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00401-025-02877-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CNS angiocentric stromal tumor (CAST), PDGFRA-mutant, a novel entity histologically mimicking meningioangiomatosis and radiologically correlating with giant Virchow–Robin spaces","authors":"Ekin Guney, Kanish Mirchia, Simone Schmid, David Capper, Jenny Meinhardt, Soonmee Cha, Han Lee, Carole Brathwaite, Nolan Altman, Emily A. Sloan, Anousheh Sayah, Kevin McGrail, Ilay Caliskan, Merryl Terry, Sandra Perez, Andrew W. Bollen, Tarik Tihan, Melike Pekmezci, Arie Perry","doi":"10.1007/s00401-025-02870-x","DOIUrl":"10.1007/s00401-025-02870-x","url":null,"abstract":"","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse astrocytoma, AYA-type, frequently MAPK-altered: report of 45 patients","authors":"Omkar Singh,&nbsp;Christopher Dampier,&nbsp;Zied Abdullaev,&nbsp;Karen Dazelle,&nbsp;Hye-Jung Chung,&nbsp;Kyle Conway,&nbsp;Sandra Camelo-Piragua,&nbsp;Stewart Neill,&nbsp;Daniel Brown,&nbsp;James Stephen Nix,&nbsp;Caterina Giannini,&nbsp;Robert Macaulay,&nbsp;Daniel Marker,&nbsp;John Skaugen,&nbsp;Scott Kulich,&nbsp;Han Lee,&nbsp;Orwa Aboud,&nbsp;Peter Pytel,&nbsp;Ewa Borys,&nbsp;Arie Perry,&nbsp;Laila Naqib-Osman,&nbsp;Igor Lima Fernandes,&nbsp;Qinwen Mao,&nbsp;Mouied Alashari,&nbsp;Cheddhi Thomas,&nbsp;Jeffrey Helgager,&nbsp;Maria A. Gubbiotti,&nbsp;John Newman,&nbsp;Nishant Tiwari,&nbsp;Patrick J. Cimino,&nbsp;Martha Quezado,&nbsp;Kenneth D. Aldape,&nbsp;MacLean P. Nasrallah","doi":"10.1007/s00401-025-02873-8","DOIUrl":"10.1007/s00401-025-02873-8","url":null,"abstract":"<div><p>A putative molecular subtype of IDH-wildtype diffuse glioma with recurrent MAPK pathway alterations has recently been reported. By dimensionality reduction analysis of genome-wide methylation profiling, these tumors form a distinct methylation cluster of gliomas. Characterization of 47 tumors from 45 patients reveals that these gliomas are predominantly supratentorial in young adults, are highly infiltrative, and harbor mitogen-activated protein kinase (MAPK) pathway alterations with high rates of <i>CDKN2A/2B</i> deletion, <i>PDGFRA</i> amplification, <i>MYCN</i> amplification, <i>NF1</i> variants, and <i>BRAF</i> alterations. The tumors’ epigenetics are distinct from other adult and pediatric gliomas in the 2021 World Health Organization (WHO) classification. The histology of the gliomas most often demonstrates high-grade astrocytic features, but can be variable from tumor to tumor, as well as fall into a spectrum of histologic grades. Outcomes show considerable variability based on histologic grade and molecular features, supporting grading within this group of tumors to ensure optimal care choices on an individual patient basis. These unifying epigenetic, sequencing, and infiltrative astrocytic features allow the tumors to be considered diffuse astrocytoma, adolescent, and young adult-type, with MAPK alterations (DAYA).</p></div>","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00401-025-02873-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures","authors":"Rahel Feleke,&nbsp;Simona Jogaudaite,&nbsp;Elisavet Velentza-Almpani,&nbsp;Leung Yeung-Yeung,&nbsp;Daniel Clode,&nbsp;Jeong Hun Ko,&nbsp;Ben Shin,&nbsp;Steve Matthews,&nbsp;Maria Otero-Jimenez,&nbsp;Marcelina J. Wojewska,&nbsp;Sandra Gray-Rodriguez,&nbsp;Sarah J. Marzi,&nbsp;Maxwell P. Spires-Jones,&nbsp;Tara L. Spires-Jones,&nbsp;Michael R. Johnson,&nbsp;Javier Alegre-Abarrategui","doi":"10.1007/s00401-025-02869-4","DOIUrl":"10.1007/s00401-025-02869-4","url":null,"abstract":"<div><p>The initial molecular alterations of Alzheimer’s disease (AD) are unknown. Established AD is characterized by profound structural and transcriptional alterations in the human brain, with the hallmark neuropathological features being beta-amyloid (Aβ) accumulation in senile plaques and hyperphosphorylated fibrillar tau in neurofibrillary tangles (NFTs). Previous evidence indicates that tau multimerization into small aggregates is one of the earliest molecular alterations, anticipating the accumulation of hyperphosphorylated tau in NFTs. In this study, we investigated the seeding capacity of these early small tau multimers and the transcriptional changes associated with them, aiming to unveil early pathogenic processes in AD-type tau pathology. Early tau multimers visualized with tau proximity ligation assay (tau-PLA) in the post-mortem temporal cortex demonstrated high seeding activity detected by real-time quaking-induced conversion (RT-QuIC) assay and induction of aggregates in a tau biosensor cell line. Using single-nucleus transcriptomics, we showed that brain tissue harboring seeding-competent early tau multimers, but without significant NFT pathology, is associated with substantial gene expression alterations across diverse cell types when compared to control tissue lacking either multimers or NFTs. Differentially expressed genes, such as <i>APP</i>, <i>MAPT</i>, and <i>PSEN1,</i> exhibited significant enrichment of AD heritability in up-regulated genes within excitatory neurons, astrocytes, and oligodendrocytes. Pseudotime analysis exposed a positive correlation between the progression of tau pathology and the expression of genes marking reactive astrocytes. In summary, our results support the hypothesis that seeding-competent tau multimerization may initiate AD-type tau pathology cascades before the accumulation of tau in NFTs. This research contributes valuable insights into the early molecular events associated with AD, with implications for future diagnostic and therapeutic strategies.</p></div>","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00401-025-02869-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired remyelination in late-onset multiple sclerosis","authors":"Lidia Stork,&nbsp;Schirin Stephan,&nbsp;Adriane Kutllovci,&nbsp;Wolfgang Brück,&nbsp;Imke Metz","doi":"10.1007/s00401-025-02868-5","DOIUrl":"10.1007/s00401-025-02868-5","url":null,"abstract":"<div><p>A reduced regenerative capacity may contribute to faster disease progression and poorer relapse recovery in multiple sclerosis patients with disease onset after the age of 50, a condition known as late-onset multiple sclerosis (LOMS). We hypothesized that lesions in LOMS patients show more pronounced axonal damage, less remyelination and an altered inflammatory composition, and performed a detailed histopathological analysis of MS biopsies in patients with early-stage LOMS. The number of T cells, B cells, plasma cells, microglia/macrophages, different oligodendrocyte populations as well as the axonal density and acute axonal damage were assessed in 31 LOMS and 30 normal-onset MS (NOMS, 20–40 years old) patients. No major differences in the inflammatory infiltrate or axonal damage were found. BCAS1-positive oligodendrocytes indicating early myelinating oligodendrocytes, and mature oligodendrocytes were significantly lower in the normal-appearing white matter of LOMS compared to NOMS patients (<i>p</i> = 0.05; <i>p</i> = 0.01), with a negative correlation with age (r = − 0.5, <i>p</i> = 0.01). In active demyelinating lesions, the number of BCAS1-positive oligodendrocytes did not differ between LOMS and NOMS, but NOMS lesions showed a higher proportion of ramified cells indicating active remyelination. In LOMS, BCAS1-positive oligodendrocytes decreased with increasing lesion age, with the lowest numbers found in inactive demyelinated lesions. In contrast, NOMS patients showed high numbers of BCAS1-positive cells with an activated morphology, even in inactive demyelinated lesions. At the last follow-up, LOMS patients had a significantly higher EDSS score (median 3.5) than NOMS patients (median 3.0, <i>p</i> = 0.05). A higher EDSS score correlated with fewer mature and oligodendrocyte precursor cells in active demyelinating lesions (r = − 0.4, <i>p</i> = 0.01 and r = − 0.6, <i>p</i> = 0.003). These findings suggest a clinically relevant impaired oligodendrocyte differentiation and remyelination in LOMS. Since remyelination is essential for axonal protection, it will be necessary to consider the complex and dynamic tissue environment when researching therapeutics aimed at fostering the differentiation of oligodendrocyte precursor cells into myelinating oligodendrocytes.</p></div>","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00401-025-02868-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong nuclear expression of HOXB13 is a reliable surrogate marker for DNA methylome profiling to distinguish myxopapillary ependymoma from spinal ependymoma","authors":"Suvendu Purkait,&nbsp;Sophia Praeger,&nbsp;Jörg Felsberg,&nbsp;David Pauck,&nbsp;Kerstin Kaulich,&nbsp;Marietta Wolter,&nbsp;David Koppstein,&nbsp;Guido Reifenberger","doi":"10.1007/s00401-025-02866-7","DOIUrl":"10.1007/s00401-025-02866-7","url":null,"abstract":"<div><p>Spinal ependymoma and myxopapillary ependymoma are the two most common spinal ependymal tumor types that feature distinct histological characteristics, genetic alterations and DNA methylation profiles. Their histological distinction may be difficult in individual cases and molecular diagnostic assessment, in particular DNA methylome profiling, may then be required to assign the correct diagnosis. Expression of the homeobox gene <i>HOXB13</i> at the mRNA and protein levels has been reported as a frequent finding in myxopapillary ependymoma that may serve as a diagnostic marker for these tumors. Here, we evaluated the diagnostic role of HOXB13 immunostaining in 143 spinal neoplasms, comprising 54 histologically classified myxopapillary ependymomas, 46 histologically classified spinal ependymomas, and various other tumor types. Immunohistochemical results for HOXB13 protein were compared to molecular findings obtained by bead array-based DNA methylation and DNA copy number profiling, as well as next generation gene panel sequencing-based mutational analysis. Our findings indicate strong nuclear HOXB13 expression as a reliable diagnostic marker for molecularly confirmed myxopapillary ependymoma. Moreover, we provide evidence that differential HOXB13 protein expression is related to differential <i>HOXB13</i>-associated CpG site methylation in myxopapillary vs. spinal ependymomas, which can be assessed by targeted DNA methylation analysis. Taken together, immunohistochemistry for HOXB13 protein expression and targeted DNA methylation analysis of <i>HOXB13</i> represent useful surrogate approaches that may substitute for DNA methylome profiling in routine diagnostics and facilitate precise classification of spinal ependymal tumors. In particular, strong nuclear HOXB13 immunoreactivity may serve as a novel diagnostic criterion for the classification of myxopapillary ependymoma.</p></div>","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00401-025-02866-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic traumatic encephalopathy neuropathologic change in homeless","authors":"Krisztina Danics,&nbsp;Shelley L. Forrest,&nbsp;Gabor G. Kovacs","doi":"10.1007/s00401-025-02867-6","DOIUrl":"10.1007/s00401-025-02867-6","url":null,"abstract":"","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofluid-based staging of Alzheimer’s disease","authors":"Juan Lantero-Rodriguez,&nbsp;Laia Montoliu-Gaya,&nbsp;Nicholas J. Ashton,&nbsp;Ilaria Pola,&nbsp;Joseph Therriault,&nbsp;Nesrine Rahmouni,&nbsp;Wagner S. Brum,&nbsp;Stijn Servaes,&nbsp;Jenna Stevenson,&nbsp;Guglielmo Di Molfetta,&nbsp;Burak Arslan,&nbsp;Jesse Klostranec,&nbsp;Paolo Vitali,&nbsp;Maxime Montembeault,&nbsp;Serge Gauthier,&nbsp;Cecile Tissot,&nbsp;Arthur C. Macedo,&nbsp;Tharick A. Pascoal,&nbsp;Andreas Jeromin,&nbsp;Johan Gobom,&nbsp;Kaj Blennow,&nbsp;Henrik Zetterberg,&nbsp;Pedro Rosa-Neto,&nbsp;Andrea L. Benedet","doi":"10.1007/s00401-025-02863-w","DOIUrl":"10.1007/s00401-025-02863-w","url":null,"abstract":"<div><p>Recently, conceptual systems for the in vivo staging of Alzheimer’s disease (AD) using fluid biomarkers have been suggested. Thus, it is important to assess whether available fluid biomarkers can successfully stage AD into clinically and biologically relevant categories. In the TRIAD cohort, we explored whether p-tau217, p-tau205 and NTA-tau (biomarkers of early, intermediate and late AD pathology, respectively) have potential for biofluid-based staging in cerebrospinal fluid (CSF; <i>n</i> = 219) and plasma (<i>n</i> = 150), and compared them in a paired CSF and plasma subset (<i>n</i> = 76). Our findings suggest a good concordance between biofluid staging and underlying pathology when classifying amyloid-positivity into three categories based on neurofibrillary pathology: minimal/non-existent (p-tau217 positive), early-to-intermediate (p-tau217 and p-tau205 positivity), and advanced tau tangle deposition (p-tau217, p-tau205 and NTA-tau positive), as indexed by tau-PET. Discordant cases accounted for 4.6% and 13.3% of all CSF and plasma measurements respectively (9.2% and 11.8% in paired samples). Notably, CSF- and plasma-based staging matched one another in 61.7% of the cases, while approximately 32% of the remaining participants were one to three biofluid stages higher in CSF as compared to plasma. Overall, these exploratory results suggest that biofluid staging of AD holds potential for offering valuable insights into underlying AD hallmarks and disease severity. However, its applicability beyond molecular characterization at research settings has yet to be demonstrated.</p></div>","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00401-025-02863-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constitutional variants in PTEN: a frequent finding in patients with papillary tumors of the pineal region subtype B (PTPR-B) associated with isolated loss of chromosome 10","authors":"Steffen Hirsch,&nbsp;Ramin Rahmanzade,&nbsp;Kerstin Grund,&nbsp;Christian Sutter,&nbsp;Kathrin Schramm,&nbsp;Florian Selt,&nbsp;Jonas Ecker,&nbsp;Barbara C. Jones,&nbsp;Daniel Schrimpf,&nbsp;Martin Demmert,&nbsp;Ana S. Guerreiro Stücklin,&nbsp;Pablo Hernaiz Driever,&nbsp;Markus Mezger,&nbsp;Ines Brecht,&nbsp;Sasan D. Adib,&nbsp;Bastian Brummel,&nbsp;Dominik Sturm,&nbsp;Nicola Dikow,&nbsp;Maja Hempel,&nbsp;Till Milde,&nbsp;Kristian Pajtler,&nbsp;David T. W. Jones,&nbsp;Stefan M. Pfister,&nbsp;Andreas von Deimling,&nbsp;Felix Sahm,&nbsp;Christian P. Schaaf","doi":"10.1007/s00401-025-02865-8","DOIUrl":"10.1007/s00401-025-02865-8","url":null,"abstract":"","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00401-025-02865-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity","authors":"Sujala Ghatamaneni,&nbsp;Courtney Hruska,&nbsp;Ian Shin,&nbsp;Tyler Bruinsma,&nbsp;Nancy Scott,&nbsp;Jeyeon Lee,&nbsp;Ping Fang,&nbsp;Hoon-Ki Min,&nbsp;Christina M. Moloney,&nbsp;Ashley C. Wood,&nbsp;Eleni Constantopoulos,&nbsp;Ross R. Reichard,&nbsp;Christopher G. Schwarz,&nbsp;David T. Jones,&nbsp;Jonathan Graff-Radford,&nbsp;David S. Knopman,&nbsp;Clifford R. Jack Jr.,&nbsp;Ronald C. Petersen,&nbsp;Dennis W. Dickson,&nbsp;Melissa E. Murray,&nbsp;Val J. Lowe","doi":"10.1007/s00401-025-02864-9","DOIUrl":"10.1007/s00401-025-02864-9","url":null,"abstract":"<div><p>Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer’s disease (AD). The maturity level of neurofibrillary tangles can affect its recognition by biomarkers. Early detection of tau aggregates regarding tangle pathology is of interest in early diagnosis and comparison of tau radiotracers in this aspect is important. This study focused on head to head pathologic comparison of [¹⁸F]MK-6240 and [¹⁸F]Flortaucipir postmortem binding as seen on high resolution autoradiography as compared to CP-13 (early tangle maturity) and PHF-1 (middling tangle maturity) immunohistochemistry (IHC) to evaluate the tangle maturity pathology specificity of binding for tau aggregates in AD, atypical AD and non-AD tauopathies. Analyses were performed on serial 5 μm formalin-fixed paraffin-embedded human brain sections acquired from the Mayo Clinic brain bank. Visual assessment of colocalization with IHC as well as quantitative analyses were used. Evaluation of the tracers’ off-target binding profiles were performed. Both tracers had similar binding properties for tau aggregates with preference to middling tangle maturity as shown by comparison to immunohistochemical distributions. Both the tracers showed strong binding to AD tau aggregates and no or minimal binding to non-AD tauopathies which corroborates with other studies.</p></div>","PeriodicalId":7012,"journal":{"name":"Acta Neuropathologica","volume":"149 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00401-025-02864-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}