Acta medica Okayama最新文献

A Case of Aniline Poisoning Manifesting as Cyanosis with Unknown Cause. 苯胺中毒表现为不明原因的发绀1例。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68729

Kenichi Taguchi, Kazuya Nishii, Sakura Hata, Shoichi Kuyama, Shoichi Tanaka

引用次数: 0

An Asymptomatic Perigraft Setoma in a Patient who Underwent Aortic Root Replacement for Annulo-Aortic Ectasia. 一例因主动脉瓣扩张而行主动脉根置换术的无症状周围膜瘤。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68728

Yasufumi Fujita, Shuji Shimizu

引用次数: 0

Immunometabolic Regulation of Innate Immunity in Systemic Lupus Erythematosus. 系统性红斑狼疮先天免疫的免疫代谢调节。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68722

Haruki Watanabe, Yoshinori Matsumoto, Jun Wada

引用次数: 0

Investigation of Cup Placement Position in Total Hip Arthroplasty with Cup-side Implant Placement in Computed Tomography Horizontal Sections. 全髋关节置换术中杯侧置入术杯位的计算机断层水平切片研究。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68725

Shuro Furuichi, Shigeru Mitani, Hirosuke Endo, Yoshifumi Namba, Toyohiro Kawamoto

{"title":"Investigation of Cup Placement Position in Total Hip Arthroplasty with Cup-side Implant Placement in Computed Tomography Horizontal Sections.","authors":"Shuro Furuichi, Shigeru Mitani, Hirosuke Endo, Yoshifumi Namba, Toyohiro Kawamoto","doi":"10.18926/AMO/68725","DOIUrl":"https://doi.org/10.18926/AMO/68725","url":null,"abstract":"The position attained in total hip arthroplasty (THA) is ideally in the center of the horizontal plane of the acetabulum. However, central placement is not always possible. We hypothesized that differences in approach result in individual differences in cup positioning; thus, we investigated the cup positions of 217 hips that underwent THA. The acetabulum's anteroposterior diameter was measured, and the cups placed within 2 mm of the line perpendicular to the center as a central placement (central). Of the 217 hips, 68, 114, and 35 hips were anterior, central, and posterior, respectively. In 21 hips, anteroposterior deviation was noted. Among patients operated using the anterolateral approach, 48, 93, and 30 hips were anterior, central, and posterior, respectively. Among those operated using the posterolateral approach, 16, 20, and 4 hips were anterior, central, and posterior, respectively. The cup position shifted either anteriorly or posteriorly to the acetabulum in approximately half of all hips operated using both approaches and tended to shift anteriorly in the hips operated using the posterolateral approach. During THA surgery, it is important to operate with awareness of the center of the acetabulum.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"177-184"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous Stimulation with Glycolaldehyde-derived Advanced Glycation End Product Reduces Aggrecan and COL2A1 Production via RAGE in Human OUMS-27 Chondrosarcoma Cells. 持续刺激乙醇醛衍生的晚期糖基化终产物通过RAGE减少人OUMS-27软骨肉瘤细胞中聚集蛋白和COL2A1的产生

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68723

Omer Faruk Hatipoglu, Takashi Nishinaka, Kursat Oguz Yaykasli, Shuji Mori, Masahiro Watanabe, Takao Toyomura, Masahiro Nishibori, Satoshi Hirohata, Hideo Takahashi, Hidenori Wake

{"title":"Continuous Stimulation with Glycolaldehyde-derived Advanced Glycation End Product Reduces Aggrecan and COL2A1 Production via RAGE in Human OUMS-27 Chondrosarcoma Cells.","authors":"Omer Faruk Hatipoglu, Takashi Nishinaka, Kursat Oguz Yaykasli, Shuji Mori, Masahiro Watanabe, Takao Toyomura, Masahiro Nishibori, Satoshi Hirohata, Hideo Takahashi, Hidenori Wake","doi":"10.18926/AMO/68723","DOIUrl":"https://doi.org/10.18926/AMO/68723","url":null,"abstract":"Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"157-166"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Chromophobe Renal Cell Carcinoma Metastasizing to the Cervical Lymph Nodes after Long-term Follow-up. 长期随访后憎色性肾细胞癌转移至颈部淋巴结1例。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68730

Makoto Watanabe, Tomoyuki Ogawa, Kanao Kobayashi, Narutaka Katsuya, Akira Ishikawa, Takao Hamamoto, Hiroaki Tahara, Tsutomu Ueda, Sachio Takeno

引用次数: 0

Emotional Changes among Young Patients with Breast Cancer to Foster Relationship-Building with Their Partners: A Qualitative Study. 年轻乳腺癌患者的情绪变化促进其与伴侣的关系：一项定性研究。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68726

Ayumi Yoshikawa, Naruto Taira, Mayumi Okanaga, Shinya Saito

{"title":"Emotional Changes among Young Patients with Breast Cancer to Foster Relationship-Building with Their Partners: A Qualitative Study.","authors":"Ayumi Yoshikawa, Naruto Taira, Mayumi Okanaga, Shinya Saito","doi":"10.18926/AMO/68726","DOIUrl":"https://doi.org/10.18926/AMO/68726","url":null,"abstract":"We investigated the emotional changes that young patients with breast cancer need to undergo in order to foster relationship-building with their partners by conducting a qualitative descriptive study (March 1 to Nov. 26, 2021) and semi-structured interviews with eight postoperative patients (age 20-40 years) with breast cancer. The data were analyzed using the modified grounded theory approach (M-GTA), yielding five categories: (i) Awareness of being a breast cancer patient, (ii) Being at a loss, (iii) Support from significant others, (iv) The struggle to transition from being a patient with cancer to becoming \"the person I want to be\", and (v) Reaching the \"me\" I want to be who can face building a relationship with a partner. These findings suggest that young breast cancer patients must feel that they can lead a normal life through activities such as work or acquiring qualifications before building relationships with their partners, and that getting closer to their desired selves is important. Nurses can provide information to young patients with breast cancer to assist them in building a solid relationship with their partners. We believe that this support may enhance the patients' quality of life and help them achieve stronger relationships with their partners.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"185-195"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rheumatoid Arthritis with Rapid Destructive Arthropathy of the Shoulder due to Calcium Pyrophosphate Deposition. 焦磷酸钙沉积引起的类风湿性关节炎伴快速破坏性肩关节病变。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68727

Naoki Kondo, Rika Kakutani, Tomoharu Mochizuki, Junichi Wakui, Nariaki Hao, Eiji Kinoshita, Hiroyuki Kawashima

引用次数: 0

Promising Effectiveness of Combined Chemotherapy and Immunotherapy in Patients with Advanced Non-small Cell Lung Cancer: A Real-World Prospective Observational Study (CS-Lung-003). 化疗和免疫治疗联合治疗晚期非小细胞肺癌的疗效：一项现实世界前瞻性观察研究（CS-Lung-003）。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68724

Nobuhiro Kanaji, Kazuya Nishii, Yukari Tsubata, Mika Nakao, Takae Okuno, Sachi Okawa, Kenji Takata, Masahiro Kodani, Masahiro Yamasaki, Kazunori Fujitaka, Tetsuya Kubota, Masaaki Inoue, Naoki Watanabe, Katsuyuki Hotta

{"title":"Promising Effectiveness of Combined Chemotherapy and Immunotherapy in Patients with Advanced Non-small Cell Lung Cancer: A Real-World Prospective Observational Study (CS-Lung-003).","authors":"Nobuhiro Kanaji, Kazuya Nishii, Yukari Tsubata, Mika Nakao, Takae Okuno, Sachi Okawa, Kenji Takata, Masahiro Kodani, Masahiro Yamasaki, Kazunori Fujitaka, Tetsuya Kubota, Masaaki Inoue, Naoki Watanabe, Katsuyuki Hotta","doi":"10.18926/AMO/68724","DOIUrl":"10.18926/AMO/68724","url":null,"abstract":"This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"167-176"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Postoperative Irradiation in Patients with cN0 Early Breast Cancer Treated with Sentinel Lymph Node Surgery. 前哨淋巴结手术治疗cN0早期乳腺癌患者的术后放疗效果。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-04-01 DOI: 10.18926/AMO/68648

Hiroshi Isozaki, Sasau Matsumoto, Takehiro Takama, Yuka Isozaki

{"title":"Effectiveness of Postoperative Irradiation in Patients with cN0 Early Breast Cancer Treated with Sentinel Lymph Node Surgery.","authors":"Hiroshi Isozaki, Sasau Matsumoto, Takehiro Takama, Yuka Isozaki","doi":"10.18926/AMO/68648","DOIUrl":"https://doi.org/10.18926/AMO/68648","url":null,"abstract":"To evaluate the effectiveness of postoperative irradiation (POI) for patients with cN0 early breast cancer, we retrospectively analyzed the cases of 650 consecutive breast cancer patients who underwent sentinel lymph node (SLN)-guided surgery (2005-2022) at our hospital. In this cohort, 53% (278/521) of the patients who underwent breast conservative surgery (BCS) and 96% (124/129) of those treated with mastectomy did not receive POI. The patients who underwent BCS were treated with POI using opposing tangential field irradiation. A false negative (FN) SLN was retrospectively defined as a negative metastasis in SLN plus positive recurrence in the axillary lymph nodes. Recurrence was detected in 83 patients. A logistic regression analysis revealed that the nuclear grade (odds ratio [OR] 1.69), POI (OR 0.41), and postoperative hormone therapy (OR 0.40) were each significantly related to recurrence. The 26.1% (12/46) FN rate of the non-POI patients decreased to 5.8% (1/17) compared to those treated with POI. The rate of axillary recurrence was significantly lower in the POI group (0.4%) versus the non-POI group (2.7%) (p=0.0355). The rate of locoregional recurrence was also significantly lower in the POI group (2.0%) versus the non-POI group (13.4%) (p<0.0001). No significant difference was observed in the rate of distant recurrence between the POI (4.0%) and non-POI (3.3%) (p=0.831) groups. These results indicated that the postoperative opposing tangential field irradiation of conserved breast tissue inhibited recurrence in the axillary lymph nodes.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 2","pages":"101-107"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0