Acta medica Okayama最新文献

Photoinitiators Induce Histamine Production in Human Mast Cells. 光引发剂诱导人肥大细胞产生组胺。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-02-01 DOI: 10.18926/AMO/68362

Taro Miura, Yoichi Kawasaki, Hirofumi Hamano, Yoshito Zamami, Toshiaki Sendo

引用次数: 0

A Rare Case of Compression Neuritis due to Intraorbital Arteriovenous Fistula (IOAVF) Mimicking Retrobulbar Optic Neuritis. 眶内动静脉瘘致压迫性神经炎1例，模拟球后视神经炎。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-02-01 DOI: 10.18926/AMO/68363

Shun Minakawa, Masayuki Hirano, Kazuya Takahashi, Yuta Imamura, Takashi Watanabe

引用次数: 0

Gastrectomy Causes an Imbalance in the Trunk Muscles. 胃切除术导致躯干肌肉不平衡。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-02-01 DOI: 10.18926/AMO/68354

Nanami Ikeya, Atsushi Okita, Shinsuke Hashida, Sumiharu Yamamoto, Hirokuni Ikeda, Kazunori Tsukuda, Shinichi Toyooka

{"title":"Gastrectomy Causes an Imbalance in the Trunk Muscles.","authors":"Nanami Ikeya, Atsushi Okita, Shinsuke Hashida, Sumiharu Yamamoto, Hirokuni Ikeda, Kazunori Tsukuda, Shinichi Toyooka","doi":"10.18926/AMO/68354","DOIUrl":"https://doi.org/10.18926/AMO/68354","url":null,"abstract":"Muscle loss negatively affects gastrectomy prognosis. However, muscle loss is recognized as a systemic change, and individual muscle function is often overlooked. We investigated changes in the muscle volume of individual muscles after gastrectomy to identify clues for prognostic factors and optimal rehabilitation programs. Patients who underwent R0 gastrectomy for Stage I gastric cancer at our hospital from 2015 to 2021 were retrospectively selected to minimize the effects of malignancy and chemotherapy. Trunk muscle volume was measured by computed tomography to analyze body composition changes. Statistical analysis was performed to identify risk factors related to body composition changes. We compared the preoperative and 6-month postoperative conditions of 59 patients after gastrectomy. There was no difference in the psoas major muscle, a conventional surrogate marker of sarcopenia. There were significant decreases in the erector spinae (p=0.01) and lateral abdominal (p=0.01) muscles, and a significant increase in the rectus abdominis muscle (p=0.02). No significant correlation was found between these muscle changes and nutritional status. Body composition imbalance may serve as a new indicator of the general condition of patients after gastrectomy. Rehabilitation to correct this imbalance may improve prognosis after gastrectomy.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 1","pages":"9-19"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Prostate Cancer Grades Using Radiomic Features. 利用放射学特征预测前列腺癌分级。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-02-01 DOI: 10.18926/AMO/68355

Yasuhiro Yamamoto, Takafumi Haraguchi, Kaori Matsuda, Yoshio Okazaki, Shin Kimoto, Nozomu Tanji, Atsushi Matsumoto, Yasuyuki Kobayashi, Hidefumi Mimura, Takao Hiraki

{"title":"Prediction of Prostate Cancer Grades Using Radiomic Features.","authors":"Yasuhiro Yamamoto, Takafumi Haraguchi, Kaori Matsuda, Yoshio Okazaki, Shin Kimoto, Nozomu Tanji, Atsushi Matsumoto, Yasuyuki Kobayashi, Hidefumi Mimura, Takao Hiraki","doi":"10.18926/AMO/68355","DOIUrl":"https://doi.org/10.18926/AMO/68355","url":null,"abstract":"We developed a machine learning model for predicting prostate cancer (PCa) grades using radiomic features of magnetic resonance imaging. 112 patients diagnosed with PCa based on prostate biopsy between January 2014 and December 2021 were evaluated. Logistic regression was used to construct two prediction models, one using radiomic features and prostate-specific antigen (PSA) values (Radiomics model) and the other Prostate Imaging-Reporting and Data System (PI-RADS) scores and PSA values (PI-RADS model), to differentiate high-grade (Gleason score [GS] ≥ 8) from intermediate or low-grade (GS < 8) PCa. Five imaging features were selected for the Radiomics model using the Gini coefficient. Model performance was evaluated using AUC, sensitivity, and specificity. The models were compared by leave-one-out cross-validation with Ridge regularization. Furthermore, the Radiomics model was evaluated using the holdout method and represented by a nomogram. The AUC of the Radiomics and PI-RADS models differed significantly (0.799, 95% CI: 0.712-0.869; and 0.710, 95% CI: 0.617-0.792, respectively). Using holdout method, the Radiomics model yielded AUC of 0.778 (95% CI: 0.552-0.925), sensitivity of 0.769, and specificity of 0.778. It outperformed the PI-RADS model and could be useful in predicting PCa grades, potentially aiding in determining appropriate treatment approaches in PCa patients.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 1","pages":"21-30"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate Effects of a Single Home-based Rehabilitation Treatment on Balance Performance and Toe-Grip Strength in Elderly Subjects Continuing the Same Rehabilitation Program. 单次家庭康复治疗对继续进行相同康复计划的老年人平衡能力和脚趾握力的直接影响。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-02-01 DOI: 10.18926/AMO/68361

Kazunori Kojima, Takuya Ujikawa, Toshiro Ono

引用次数: 0

Endothelial Cell Polarity in Health and Disease. 内皮细胞极性在健康和疾病。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-02-01 DOI: 10.18926/AMO/68353

Moe Thiha, Takao Hikita, Masanori Nakayama

{"title":"Endothelial Cell Polarity in Health and Disease.","authors":"Moe Thiha, Takao Hikita, Masanori Nakayama","doi":"10.18926/AMO/68353","DOIUrl":"https://doi.org/10.18926/AMO/68353","url":null,"abstract":"Endothelial cell polarity is fundamental to the organization and function of blood vessels, influencing processes such as angiogenesis, vascular stability, and response to shear stress. This review elaborates on the molecular mechanisms that regulate endothelial cell polarity, focusing on key players like the PAR polarity complex and Rho family GTPases. These pathways coordinate the front-rear, apical-basal and planar polarity of endothelial cells, which are essential for the proper formation and maintenance of vascular structures. In health, endothelial polarity ensures not only the orderly development of blood vessels, with tip cells adopting distinct polarities during angiogenesis, but also ensures proper vascular integrity and function. In disease states, however, disruptions in polarity contribute to pathologies such as coronary artery disease, where altered planar polarity exacerbates atherosclerosis, and cancer, where disrupted polarity in tumor vasculature leads to abnormal vessel growth and function. Understanding cell polarity and its disruption is fundamental not only to comprehending how cells interact with their microenvironment and organize themselves into complex, organ-specific tissues but also to developing novel, targeted, and therapeutic strategies for a range of diseases, from cardiovascular disorders to malignancies, ultimately improving patient outcomes.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 1","pages":"1-7"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective Analysis of the Safety of High-Volume Dental Articaine Preparations for Japanese Patients. 日本患者大剂量牙科关节碱制剂安全性的回顾性分析。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-02-01 DOI: 10.18926/AMO/68356

Shigeru Maeda, Atiphan Pimkhaokham, Michihiro Yoshida, Hiroki Hosoi, Ayako Ohshima, Ryoko Kurisu, Nozomi Utsumi, Hitoshi Higuchi, Takuya Miyawaki

{"title":"Retrospective Analysis of the Safety of High-Volume Dental Articaine Preparations for Japanese Patients.","authors":"Shigeru Maeda, Atiphan Pimkhaokham, Michihiro Yoshida, Hiroki Hosoi, Ayako Ohshima, Ryoko Kurisu, Nozomi Utsumi, Hitoshi Higuchi, Takuya Miyawaki","doi":"10.18926/AMO/68356","DOIUrl":"https://doi.org/10.18926/AMO/68356","url":null,"abstract":"We retrospectively analyzed the safety of the use of articaine, an amide-type local anesthetic, in Japanese dental patients (n=300) treated in Thailand in 2015-2017. The dosage, adverse events (AEs) caused by local anesthesia, and treatment efficacy were examined. Articaine, which is safe for patients with liver impairments due to its unique metabolism, has not been thoroughly tested in Japan for doses above 5.1 mL. Eighty of the present patients had undergone root canal treatment (RCT), 71 underwent tooth extraction, and 149 underwent implant-related surgery. More than three articaine cartridges were used in 41 patients, and no AEs occurred in these cases. The only AE occurred in a 52-year-old woman who was treated with three cartridges and presented with what appeared to be hyperventilation syndrome; she later recovered and received her dental treatment as scheduled. Most treatments were completed with three or fewer cartridges, suggesting that this number is generally sufficient. Our findings, particularly the low AE risk even with doses exceeding three cartridges, support the potential applicability of the overseas recommended maximum dose of articaine (7 mg/kg) in Japanese patients. This conclusion is significant for advancing dental anesthetic practices and ensuring patient safety and treatment efficacy in Japan.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 1","pages":"31-37"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could the Trabecular Bone Score Be a Complementary Tool for Evaluating Degenerative Lumbar Vertebrae? 骨小梁评分能作为评估腰椎退行性椎体的辅助工具吗？

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2025-02-01 DOI: 10.18926/AMO/68360

Shinichiro Takao, Koji Uotani, Haruo Misawa, Tomoko Tetsunaga, Kensuke Shinohara, Kentaro Yamane, Yoshiaki Oda, Hironori Tsuji, Yuya Kajiki, Toshifumi Ozaki

{"title":"Could the Trabecular Bone Score Be a Complementary Tool for Evaluating Degenerative Lumbar Vertebrae?","authors":"Shinichiro Takao, Koji Uotani, Haruo Misawa, Tomoko Tetsunaga, Kensuke Shinohara, Kentaro Yamane, Yoshiaki Oda, Hironori Tsuji, Yuya Kajiki, Toshifumi Ozaki","doi":"10.18926/AMO/68360","DOIUrl":"https://doi.org/10.18926/AMO/68360","url":null,"abstract":"Evaluating vertebral bone mass and quality in the elderly poses challenges due to degenerative changes. This study aims to elucidate the usefulness of the trabecular bone score (TBS) by examining the relationship between bone mineral density (BMD), TBS, and Hounsfield unit (HU) values. A retrospective analysis of 599 vertebrae from 152 patients (mean age 69.0 years; range 44-89; 74 males and 78 females) undergoing dual-energy X-ray absorptiometry (DXA) and CT scans was conducted. Vertebrae were categorized into three grades based on the degree of degeneration. The TBS was calculated from DXA images, and the HU value was measured by placing a region of interest on an axial image of the vertebral mid-body. One-way analysis of variance and Pearson's correlation tests were employed to investigate the relationship between BMD and TBS or HU values. While lumbar BMD significantly increased (p<0.01) with degenerative changes, TBS and HU values showed no significant differences. The correlations between lumbar BMD and TBS values, and between BMD and HU values, were stronger without degenerative changes than with degenerative changes. Significantly different HU values were observed between the right and left sides of severely degenerated vertebrae. Severe degenerative changes, particularly those associated with sclerosis, may impact HU values. TBS exhibits greater potential than HU values as a complementary tool.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 1","pages":"39-45"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partial versus Radical Nephrectomy for Small Renal Cancer: Comparative Propensity Score-Matching Analysis of Cardiovascular Event Risk. 小肾癌部分与根治性肾切除术：心血管事件风险的比较倾向评分匹配分析。

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-12-01 DOI: 10.18926/AMO/67868

Risa Kubota, Kensuke Bekku, Satoshi Katayama, Takehiro Iwata, Shingo Nishimura, Kohei Edamura, Tomoko Kobayashi, Yasuyuki Kobayashi, Motoo Araki

{"title":"Partial versus Radical Nephrectomy for Small Renal Cancer: Comparative Propensity Score-Matching Analysis of Cardiovascular Event Risk.","authors":"Risa Kubota, Kensuke Bekku, Satoshi Katayama, Takehiro Iwata, Shingo Nishimura, Kohei Edamura, Tomoko Kobayashi, Yasuyuki Kobayashi, Motoo Araki","doi":"10.18926/AMO/67868","DOIUrl":"https://doi.org/10.18926/AMO/67868","url":null,"abstract":"Although partial nephrectomy (PN) is preferred over radical nephrectomy (RN) for preserving renal function in patients with cT1 renal cancer, its impact on cardiovascular events (CVe) remains controversial. This study aimed to compare PN and RN in regard to the occurrence of CVe, including cerebrovascular events and exacerbation of hypertension (HT). We retrospectively analyzed 418 consecutive patients who underwent PN or RN for cT1 renal cancer. Propensity score-matching analysis was used to adjust for imbalances between patients who underwent PN and RN, leaving 102 patients in each group. The 5-year probability of cumulative CVe incidence was 6% in the PN group and 12% in the RN group (p=0.03), with a median follow-up of 73.5 months. The statistical significance was retained after propensity score matching for patients without preoperative proteinuria (p=0.03). For all CVe including cerebrovascular events and exacerbation of HT analyzed, PN provided a lower probability of occurrence than RN in patients with small renal cancers.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 6","pages":"429-437"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Gangrenous Cholecystitis and the Outcomes of Early Cholecystectomy: A Retrospective Study of a Single-Center City General Hospital. 坏疽性胆囊炎的危险因素及早期胆囊切除术的预后：一项单中心城市综合医院的回顾性研究

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2024-12-01 DOI: 10.18926/AMO/67869

Mampei Yamashita, Takayuki Tanaka, Yorihisa Sumida, Shoto Yamazaki, Yuki Hara, Akiko Fukuda, Makoto Hisanaga, Koki Wakata, Masato Araki, Susumu Eguchi

{"title":"Risk Factors for Gangrenous Cholecystitis and the Outcomes of Early Cholecystectomy: A Retrospective Study of a Single-Center City General Hospital.","authors":"Mampei Yamashita, Takayuki Tanaka, Yorihisa Sumida, Shoto Yamazaki, Yuki Hara, Akiko Fukuda, Makoto Hisanaga, Koki Wakata, Masato Araki, Susumu Eguchi","doi":"10.18926/AMO/67869","DOIUrl":"https://doi.org/10.18926/AMO/67869","url":null,"abstract":"Gangrenous cholecystitis (GC) is classified as moderate acute cholecystitis according to the Tokyo Guidelines from 2018 (TG18). We evaluated the risk factors for GC and the outcomes of early cholecystectomy. A total of 136 patients who underwent emergency cholecystectomy for acute cholecystitis were retrospectively analyzed; 58 of these patients (42.6%) were diagnosed with GC (GC group) based on our retrospective pathologic diagnosis. We comparatively evaluated the patient backgrounds and surgical outcomes between the GC group and non-GC group. The GC group was significantly older and included more hypertensive patients than the non-GC group. The GC group was prescribed more antibiotics as initial treatment than the non-GC group, and they had more days between onset and surgery. The preoperative white blood cell count and C-reactive protein values were significantly higher in the GC group than in the non-GC group, and these values were predictive factors for GC. Cholecystectomy required a longer operation time and caused greater blood loss in the GC group. The GC group also had longer hospitalization times than the non-GC group; however, no significant differences were observed in terms of postoperative complications. In conclusion, gangrenous changes should be assessed when diagnosing cholecystitis, and appropriate treatment, such as surgery or drainage, should be undertaken.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 6","pages":"439-447"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0