Acta medica Okayama最新文献

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Revisiting Adrenal Crisis Triggered by Influenza Infection: Lessons from Two Fatal Cases. 重新审视流感感染引发的肾上腺危机:两个致命病例的教训。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70458
Yoshiyuki Ueda, Tetsuya Yumoto, Takashi Hongo, Takafumi Obara, Tsuyoshi Nojima, Kohei Tsukahara, Kosei Hasegawa, Natsuko Futagawa, Hiromichi Naito, Atsunori Nakao
{"title":"Revisiting Adrenal Crisis Triggered by Influenza Infection: Lessons from Two Fatal Cases.","authors":"Yoshiyuki Ueda, Tetsuya Yumoto, Takashi Hongo, Takafumi Obara, Tsuyoshi Nojima, Kohei Tsukahara, Kosei Hasegawa, Natsuko Futagawa, Hiromichi Naito, Atsunori Nakao","doi":"10.18926/AMO/70458","DOIUrl":"https://doi.org/10.18926/AMO/70458","url":null,"abstract":"<p><p>Adrenal crisis is a life-threatening endocrine emergency that can progress within hours despite a prior diagnosis and maintenance therapy. We describe a fatal influenza-triggered adrenal crisis in two patients: a child with panhypopituitarism and an adult with prior pituitary surgery, both presenting in cardiac arrest. Despite resuscitation and intravenous hydrocortisone, a fatal hypoxic-ischemic injury or multiorgan failure occurred. These cases highlight the fulminant course of an adrenal crisis and underscore the importance of early recognition, clinician awareness, prompt parenteral hydrocortisone administration, and reinforcement of education for patients, caregivers, and healthcare providers to improve preparedness and prevent avoidable deaths.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"153-157"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consistent Clinical Outcomes of Anteroinferior Minimally Invasive Plate Osteosynthesis for Midshaft Clavicle Fractures Across AO/OTA Fracture Types. 前下微创钢板内固定治疗锁骨中轴骨折AO/OTA骨折类型的一致性临床结果
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70452
Nguyen Trung Thanh, Ryo Nakamichi, Yasunori Shimamura, Taichi Saito, Takeshi Ishihara, Tomoki Furutani, Hisakazu Shitozawa, Tomoyuki Noda, Toshifumi Ozaki
{"title":"Consistent Clinical Outcomes of Anteroinferior Minimally Invasive Plate Osteosynthesis for Midshaft Clavicle Fractures Across AO/OTA Fracture Types.","authors":"Nguyen Trung Thanh, Ryo Nakamichi, Yasunori Shimamura, Taichi Saito, Takeshi Ishihara, Tomoki Furutani, Hisakazu Shitozawa, Tomoyuki Noda, Toshifumi Ozaki","doi":"10.18926/AMO/70452","DOIUrl":"https://doi.org/10.18926/AMO/70452","url":null,"abstract":"<p><p>Although the performance of minimally invasive plate osteosynthesis (MIPO) via the anteroinferior approach is increasingly adopted for midshaft clavicle fractures, the influence of fracture morphology on clinical outcomes under a standardized protocol is unclear. We retrospectively analyzed the cases of 54 patients who underwent anteroinferior MIPO for an acute midshaft clavicle fracture (AO/OTA types B1, B2, B3) performed by a single surgeon across three affiliated institutions (2009-2022). We evaluated the clinical outcomes, i.e., the surgical time, incision length, radiographic union, reduction accuracy, range of motion, pain (visual analog scale [VAS]), and complications and compared them among the three AO/OTA subtypes. The mean incision length (3.4 cm) and surgical time (71-79 min) were similar among the groups (both p>0.2). All fractures achieved radiographic union at a mean of 3.5 months. Postoperative alignment and clavicular length were maintained (length reduction -1.0±2.2 mm [B1], -0.5±2.0 mm [B2], -0.6±1.8 mm [B3]; p=0.825; angulation -0.8±3.4°, -1.1±3.1°, -0.3±3.3°; p=0.888). At 3 months, shoulder elevation and abduction were 169°-175° (p=0.079) and 164°-175° (p=0.324). Pain was minimal (100-mm VAS: ≤1 mm; p=0.782). One plate-fatigue failure occurred; no supraclavicular-nerve symptoms were recorded. Anteroinferior MIPO yielded consistent outcomes across AO/OTA types, with excellent union rates, functional recovery, and few complications, indicating that this technique is safe and reproducible for the surgical management of midshaft clavicle fractures.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"99-107"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients. 老年骨质疏松性胸腰椎塌陷的小开口椎体切除术及侧卧位单体位后路脊柱固定。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70454
Hisanori Ikuma, Tomohiko Hirose, Keisuke Kawasaki, Kazutoshi Otsuka
{"title":"Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients.","authors":"Hisanori Ikuma, Tomohiko Hirose, Keisuke Kawasaki, Kazutoshi Otsuka","doi":"10.18926/AMO/70454","DOIUrl":"https://doi.org/10.18926/AMO/70454","url":null,"abstract":"<p><p>We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in the lateral decubitus position in patients aged > 75 years with thoracolumbar vertebral collapse. The cases of 30 consecutive patients who underwent this procedure and had ≥ 1-year follow-up were retrospectively analyzed. The mean operative time was 78.8 min and the estimated blood loss was 115.7 ml per level. The complications included adjacent junctional failure (n=9, 30%), deep venous thrombosis (n=3, 10%), delirium (n=3, 10%), pleural injury (n=2, 6%), screw backout (n=1, 3%) kidney injury (n=1, 3%), chylothorax (n=1, 3%), and wound dehiscence (n=1, 3%). Seven cases (23.3%) required reoperation. Local kyphosis showed significant improvement (p<0.05) that was maintained at the final follow-up. The Japanese Orthopaedic Association Back Pain Evaluation Questionnaire and a visual analogue scale indicated significant improvement in all categories at the final follow-up (p<0.05). The use of mini-open corpectomy and posterior fixation with SPAPS can thus provide reliable radiological correction and good postoperative clinical outcomes even in patients aged > 75 years. However, a limitation of this procedure is the rate of reoperation (23.3%) for osteoporosis-related adjacent segment fracture and screw backout.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"119-129"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Nonsurgical Periodontal Treatment on Bacterial and Clinical Parameters in Down Syndrome Patients Based on 16S rRNA Gene Amplicon Sequencing. 基于16S rRNA基因扩增子测序的牙周非手术治疗对唐氏综合征患者细菌及临床参数的影响
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70451
Takahiko Shiba, Mitsuhito Takamori, Sayaka Katagiri, Ryota Kobayashi, Aki Kawauchi, Yujin Ohsugi, Peiya Lin, Daisuke Ekuni, Masahiko Egusa, Takanori Iwata, Shigeru Maeda
{"title":"Effects of Nonsurgical Periodontal Treatment on Bacterial and Clinical Parameters in Down Syndrome Patients Based on 16S rRNA Gene Amplicon Sequencing.","authors":"Takahiko Shiba, Mitsuhito Takamori, Sayaka Katagiri, Ryota Kobayashi, Aki Kawauchi, Yujin Ohsugi, Peiya Lin, Daisuke Ekuni, Masahiko Egusa, Takanori Iwata, Shigeru Maeda","doi":"10.18926/AMO/70451","DOIUrl":"https://doi.org/10.18926/AMO/70451","url":null,"abstract":"<p><p>Individuals with Down syndrome (DS) are more susceptible to periodontal disease; however, microbial changes following treatment remain insufficiently understood. This study evaluated the effects of nonsurgical periodontal therapy on clinical outcomes and oral microbiome dynamics in 6 patients with DS using 16S rRNA gene amplicon sequencing. Bacterial diversity, composition, network structure, and predicted functional pathways were analyzed using dental plaque samples. Bleeding on probing decreased significantly (p=0.047) after treatment, with a trend toward reduction in periodontal inflamed surface area (p=0.05). The abundance of Fusobacteria at the class level decreased significantly after treatment. The abundance of Mogibacterium timidum was higher in the pretreatment group than in the posttreatment group. M. timidum was positively correlated with Treponema denticola and associated with multiple bacterial taxa in the network during pretreatment. Predicted functional pathways related to aromatic compound degradation were more abundant in posttreatment samples than in pretreatment samples. An increase in the abundance of Fusobacterium and the positive correlation between T. denticola and M. timidum, together with their associations with other periodontal pathogens before treatment, may contribute to the development of periodontitis in individuals with DS. Nonsurgical periodontal therapy produces measurable clinical improvement and promotes microbial shifts in patients with DS.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"85-97"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Mixed-Methods Study on Changes in Interprofessional Education Attitudes and Fundamental Competencies: A Pre-Post Analysis of Clinical Training in Dietetic Students. 跨专业教育态度和基本能力变化的混合方法研究:营养学学生临床培训前后分析。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70453
Mika Sonoi, Norihiro Sonoi, Yoko Koyama
{"title":"A Mixed-Methods Study on Changes in Interprofessional Education Attitudes and Fundamental Competencies: A Pre-Post Analysis of Clinical Training in Dietetic Students.","authors":"Mika Sonoi, Norihiro Sonoi, Yoko Koyama","doi":"10.18926/AMO/70453","DOIUrl":"https://doi.org/10.18926/AMO/70453","url":null,"abstract":"<p><p>This study examined the effects of interprofessional education (IPE) on dietetics students during clinical training, focusing on changes in their attitudes toward IPE and their fundamental competencies. Eighty third-year female students (mean age, 21.0 years) at a Japanese women's university participated. Self-administered surveys were conducted before and after clinical training to assess attitudes toward IPE using the Readiness for Interprofessional Learning Scale (RIPLS) and the Shakaijin Kisoryoku (SKL; Fundamental Competencies for Working Persons) scale. Quantitative data were analyzed using paired t-tests, chi-squared tests, and cluster analyses. Qualitative data from open-ended responses were analyzed thematically. RIPLS and SKL scores increased significantly, from 65.3 to 68.9, and from 28. 4 to 33. 2, respectively (p<0.001). All 12 SKL items showed significant improvement. In free responses, \"initiative\" (66 mentions), \"communication\" (10), and \"execution\" (8) were the most frequently cited as improved competencies. Cluster analysis identified three groups: increasing scores (n=25), high baseline (n=30), and minimal change (n=25). No significant correlation was found between changes in RIPLS and SKL scores (r=-0.108, p=0.355). IPE integrated into clinical training may enhance dietetics students' attitudes toward interprofessional collaboration and contribute to the development of professional identity. Individualized, phased IPE implementation is recommended to accommodate differences in learner readiness.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"109-117"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete Transection of the Common Bile Duct Caused by Blunt Abdominal Trauma: A Rare Case Report. 腹部钝性创伤致胆总管完全横断1例。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70457
Shinya Sakamoto, Motoyasu Tabuchi, Akira Hamada, Rika Yoshimatsu, Yuichi Saisaka, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi
{"title":"Complete Transection of the Common Bile Duct Caused by Blunt Abdominal Trauma: A Rare Case Report.","authors":"Shinya Sakamoto, Motoyasu Tabuchi, Akira Hamada, Rika Yoshimatsu, Yuichi Saisaka, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi","doi":"10.18926/AMO/70457","DOIUrl":"https://doi.org/10.18926/AMO/70457","url":null,"abstract":"<p><p>Common bile duct (CBD) injury after blunt abdominal trauma is rare and difficult to diagnose. Delayed recognition leads to severe morbidity. A 70-year-old Japanese man was admitted after sustaining blunt abdominal trauma. Ultrasonography revealed intra-abdominal fluid, suggesting bleeding. Contrast-enhanced computed tomography revealed pancreatic head injury, intra-abdominal bleeding, and pseudoaneurysm of the anterior superior pancreatoduodenal artery (ASPDA). Bile duct injury was not evident. The application of transarterial embolization (TAE) controlled the bleeding. Canulation into the pancreatic or biliary duct was not possible during endoscopic retrograde cholangiopancreatography. An emergency laparotomy revealed severe pancreatic head and extrahepatic bile duct injuries. Pancreaticoduodenectomy/Child reconstruction was performed. Complete CBD transection was confirmed. The patient was ultimately discharged without complications. Early recognition, timely surgical management, and intensive care are essential for favorable outcomes in patients who have sustained abdominal trauma.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"147-152"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Necrotizing Fasciitis Caused by ESBL-Producing Raoultella ornithinolytica in an Immunocompromised Patient with VEXAS Syndrome. 免疫功能低下的VEXAS综合征患者中产生esbl的鸟嘌呤溶解拉乌尔氏菌引起的坏死性筋膜炎
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70456
Moe Sakamoto-Tokunaga, Takayuki Katsuyama, Masaki Matoba, Tomokazu Tamura, Natsuki Kubota, Yuya Terajima, Kenta Shidahara, Kei Hirose, Kazuya Matsumoto, Shoichi Nawachi, Takato Nakadoi, Yu Katayama, Keigo Hayashi, Yoshia Miyawaki, Eri Katsuyama, Haruki Watanabe, Mariko Takano-Narazaki, Yoshinori Matsumoto, Ken-Ei Sada, Shuma Tsuji, Kazuyoshi Gotoh, Shinnosuke Fukushima, Hideharu Hagiya, Jun Wada
{"title":"Necrotizing Fasciitis Caused by ESBL-Producing Raoultella ornithinolytica in an Immunocompromised Patient with VEXAS Syndrome.","authors":"Moe Sakamoto-Tokunaga, Takayuki Katsuyama, Masaki Matoba, Tomokazu Tamura, Natsuki Kubota, Yuya Terajima, Kenta Shidahara, Kei Hirose, Kazuya Matsumoto, Shoichi Nawachi, Takato Nakadoi, Yu Katayama, Keigo Hayashi, Yoshia Miyawaki, Eri Katsuyama, Haruki Watanabe, Mariko Takano-Narazaki, Yoshinori Matsumoto, Ken-Ei Sada, Shuma Tsuji, Kazuyoshi Gotoh, Shinnosuke Fukushima, Hideharu Hagiya, Jun Wada","doi":"10.18926/AMO/70456","DOIUrl":"https://doi.org/10.18926/AMO/70456","url":null,"abstract":"<p><p>VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory somatic) syndrome has a poor prognosis, with infections being a major cause of death. Raoultella ornithinolytica is an environmental bacterium found predominantly in soil and water. Although R. ornithinolytica can cause various infections, necrotizing fasciitis due to this bacterium has not been reported. We describe the case of an 84-year-old Japanese male with VEXAS syndrome who developed septic shock and necrotizing fasciitis while he was under immunosuppressive therapy. The pathogen was initially misidentified as R. planticola by mass spectrometry but later confirmed by whole-genome sequencing as extended spectrum β-lactamase (ESBL) produced by R. ornithinolytica. Although a life-saving leg amputation was required, the patient recovered with appropriate antibiotic therapy. R. ornithinolytica is thus able to cause severe skin infections in immunocompromised individuals.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"141-145"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Proteinuria on Postoperative Complications Following Colorectal Cancer Surgery. 蛋白尿对大肠癌术后并发症的影响。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70455
Shunsuke Nakata, Fumiaki Takatsu, Yoshihiro Mikuriya, Tomokazu Kakishita, Shinji Hato, Koji Ohta, Takaya Kobatake
{"title":"Impact of Proteinuria on Postoperative Complications Following Colorectal Cancer Surgery.","authors":"Shunsuke Nakata, Fumiaki Takatsu, Yoshihiro Mikuriya, Tomokazu Kakishita, Shinji Hato, Koji Ohta, Takaya Kobatake","doi":"10.18926/AMO/70455","DOIUrl":"https://doi.org/10.18926/AMO/70455","url":null,"abstract":"<p><p>Colorectal surgery is associated with a high incidence of postoperative complications regardless of the advances in surgical techniques and multidisciplinary treatment. Proteinuria is common in patients with malignancies, but few studies have investigated the association between preoperative proteinuria and patient prognoses, especially postoperative complications. We investigated the impact of proteinuria on patients undergoing colorectal surgery in a single-center, retrospective cohort study of 767 patients who underwent surgical resection for colorectal cancer between January 2016 and December 2022 at the National Hospital Organization Shikoku Cancer Center. Among them, 81 patients with preoperative proteinuria were compared with the control group of 686 patients without proteinuria. Our analyses revealed that the patients with proteinuria had malnutrition with a significantly lower prognostic nutritional index compared to the no-proteinuria control group (p<0.001). The proteinuria group had a significantly advanced tumor stage (p=0.005), experienced more bleeding during the surgery (p=0.002), and required more transfusions (p<0.001). Postoperative complications were significantly more frequent in the proteinuria group (p=0.03), thus demonstrating that proteinuria was independently associated with postoperative complications (p=0.045). Proteinuria in patients undergoing colorectal cancer surgery can therefore be considered a risk factor for postoperative complications.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"131-139"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Involvement of ADAM12 in TGF-β1-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts. ADAM12参与TGF-β1诱导的类风湿关节炎滑膜成纤维细胞增殖。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70450
Deting Lin, Masahiro Horita, Masahito Watanabe, Joe Hasei, Takashi Ohtsuki, Noriaki Otsuka, Chinatsu Ichikawa, Noriyuki Shimizu, Shuichi Naniwa, Toshifumi Ozaki, Keiichiro Nishida
{"title":"Involvement of ADAM12 in TGF-β1-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts.","authors":"Deting Lin, Masahiro Horita, Masahito Watanabe, Joe Hasei, Takashi Ohtsuki, Noriaki Otsuka, Chinatsu Ichikawa, Noriyuki Shimizu, Shuichi Naniwa, Toshifumi Ozaki, Keiichiro Nishida","doi":"10.18926/AMO/70450","DOIUrl":"https://doi.org/10.18926/AMO/70450","url":null,"abstract":"<p><p>A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"75-83"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Intraocular Tumor Likely from Hepatocellular Carcinoma Mimicking Panuveitis. 转移性眼内肿瘤可能来自肝细胞癌,类似全葡萄膜炎。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2026-02-01 DOI: 10.18926/AMO/70074
Eri Takasu, Yusuke Shiode, Hiroya Kindo, Shuhei Kimura, Mio Hosokawa, Ryo Matoba, Yuki Kanzaki, Tetsuro Morita, Takuya Adachi, Motoyuki Otsuka, Yuki Morizane
{"title":"Metastatic Intraocular Tumor Likely from Hepatocellular Carcinoma Mimicking Panuveitis.","authors":"Eri Takasu, Yusuke Shiode, Hiroya Kindo, Shuhei Kimura, Mio Hosokawa, Ryo Matoba, Yuki Kanzaki, Tetsuro Morita, Takuya Adachi, Motoyuki Otsuka, Yuki Morizane","doi":"10.18926/AMO/70074","DOIUrl":"10.18926/AMO/70074","url":null,"abstract":"<p><p>A 77-year-old man undergoing treatment for hepatocellular carcinoma (HCC) presented with blurred vision in his right eye, persisting for 2 months. Slit-lamp microscopy and fundus examination revealed inflammatory cells in the anterior chamber, severe vitreous opacities, and retinal vasculitis in the right eye. The patient underwent vitreous surgery with biopsy, and vitreous cytology confirmed a metastatic intraocular tumor originating from the HCC. Radiotherapy was administered to the right eye, with no recurrence of intraocular inflammation observed at 10 months post-irradiation.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 1","pages":"63-67"},"PeriodicalIF":0.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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