Acta medica Okayama最新文献_第10页

Concomitant Use of Multiple Nephrotoxins including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity: Combined Retrospective Analyses of Two Real-World Databases. 同时使用多种肾毒性药物（包括肾灌注不足药物）会导致万古霉素相关性肾毒性：两个真实世界数据库的联合回顾性分析。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-12-01 DOI: 10.18926/AMO/66151

Takashi Bando, Masayuki Chuma, Hirofumi Hamano, Takahiro Niimura, Naoto Okada, Masateru Kondo, Yuki Izumi, Shunsuke Ishida, Toshihiko Yoshioka, Mizuho Asada, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Koji Miyata, Kenta Yagi, Yuki Izawa-Ishizaka, Momoyo Azuma, Hiroaki Yanagawa, Yoshikazu Tasaki, Keisuke Ishizawa

{"title":"Concomitant Use of Multiple Nephrotoxins including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity: Combined Retrospective Analyses of Two Real-World Databases.","authors":"Takashi Bando, Masayuki Chuma, Hirofumi Hamano, Takahiro Niimura, Naoto Okada, Masateru Kondo, Yuki Izumi, Shunsuke Ishida, Toshihiko Yoshioka, Mizuho Asada, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Koji Miyata, Kenta Yagi, Yuki Izawa-Ishizaka, Momoyo Azuma, Hiroaki Yanagawa, Yoshikazu Tasaki, Keisuke Ishizawa","doi":"10.18926/AMO/66151","DOIUrl":"10.18926/AMO/66151","url":null,"abstract":"There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"77 6","pages":"595-605"},"PeriodicalIF":0.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fine Particulate Matter and Diabetes Prevalence in Okayama, Japan. 日本冈山的细颗粒物与糖尿病发病率。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-12-01 DOI: 10.18926/AMO/66152

Yasunari Tani, Saori Kashima, Toshiharu Mitsuhashi, Etsuji Suzuki, Soshi Takao, Takashi Yorifuji

引用次数: 0

Survey of Osteoarthritis of the Shoulder in Patients who Underwent Knee Arthroplasty for Knee Osteoarthritis. 因膝关节骨性关节炎而接受膝关节置换术的患者肩关节骨性关节炎调查。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-12-01 DOI: 10.18926/AMO/66153

Yoshiaki Miyake, Yoshifumi Namba, Shigeru Mitani, Norifumi Umehara, Toyohiro Kawamoto, Shuro Furuichi

引用次数: 0

A Case of Migration of a Hydrogel Spacer for Radiotherapy into the Pulmonary Artery. 一例放疗用水凝胶垫片移入肺动脉的病例。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-12-01 DOI: 10.18926/AMO/66157

Katsuhide Kojima, Yuka Takahashi, Soichi Sugiyama, Yudai Asano, Nanako Okawa, Satoko Makimoto, Fumiyo Higaki, Toshihiro Iguchi, Takao Hiraki

引用次数: 0

Prenatal Torsion of Radial Polydactyly: A Gangrenous Mass at the Base of the Thumb. 桡骨多指畸形的产前扭转：拇指根部的坏疽肿块

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-12-01 DOI: 10.18926/AMO/66158

Daisuke Watanabe, Yohei Hasebe, Hiroshi Mitsui, Naoki Oishi, Shin Kasai, Koshi Akahane, Satoru Kojika, Takeshi Inukai

引用次数: 0

Abnormal Vaginal Cytology after Total Laparoscopic Hysterectomy in Patients with Cervical Intraepithelial Neoplasia. 宫颈上皮内瘤变患者全腹腔镜子宫切除术后阴道细胞学检查异常

IF 0.6 4区医学

Acta medica Okayama Pub Date : 2023-12-01 DOI: 10.18926/AMO/66155

Yumi Hibino, Mika Okazawa-Sakai, Takanori Yokoyama, Etsuko Fujimoto, Shinichi Okame, Norihiro Teramoto, Kazuhiro Takehara

{"title":"Abnormal Vaginal Cytology after Total Laparoscopic Hysterectomy in Patients with Cervical Intraepithelial Neoplasia.","authors":"Yumi Hibino, Mika Okazawa-Sakai, Takanori Yokoyama, Etsuko Fujimoto, Shinichi Okame, Norihiro Teramoto, Kazuhiro Takehara","doi":"10.18926/AMO/66155","DOIUrl":"10.18926/AMO/66155","url":null,"abstract":"To explore the incidence of abnormal vaginal cytology after total laparoscopic hysterectomy for the treatment of cervical intraepithelial neoplasia 3, we retrospectively analyzed the medical records of patients treated at NHO Shikoku Cancer Center (Japan) in 2014-2019. The cases of 99 patients who underwent a laparoscopic (n=36) or open (n=63) hysterectomy and postoperative follow-up were examined. Abnormal vaginal cytology was detected in 13.9% (5/36) of the laparoscopic-surgery (LS) group and 14.3% (9/63) of the open-surgery (OS) group. A vaginal biopsy was performed at the physicians' discretion; one LS patient and six OS patients were diagnosed with vaginal intraepithelial neoplasia. The cumulative incidence of abnormal vaginal cytology at 3 years post-hysterectomy was 21.4% (LS group) and 20.5% (OS group), a nonsignificant difference. A multivariate analysis showed that age > 50 years was the only independent risk factor for abnormal vaginal cytology among the covariates examined including age; body mass index; histories of vaginal delivery, abdominal surgery, and smoking; and surgical approach (hazard ratio 8.11; 95% confidence interval 1.73-37.98; p=0.01). These results suggest that the occurrence of abnormal vaginal cytology after a hysterectomy may not be influenced by the laparoscopic procedure but is associated with older age.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"77 6","pages":"627-634"},"PeriodicalIF":0.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dramatic Response to Tezepelumab as an Initial Biologic Agent for Refractory Asthma Associated with Type 2 and Non-type 2 Traits. 特珠单抗作为初始生物制剂治疗伴有 2 型和非 2 型特征的难治性哮喘效果显著。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-12-01 DOI: 10.18926/AMO/66161

Daisuke Minami, Takeshi Hosoya, Masaharu Hosoya, Akichika Nagano, Yasuhiro Nakajima, Nobuaki Miyahara, Arihiko Kanehiro

引用次数: 0

Low Patient Weight and Long Intubation Time Are Key Factors for Pain during Colonoscopy. 患者体重低和插管时间长是结肠镜检查期间疼痛的关键因素。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-10-01 DOI: 10.18926/AMO/65969

Shohei Oka, Keita Harada, Shumpei Yamamoto, Eriko Yasutomi, Shoko Igawa, Masayasu Ohmori, Mami Hirai, Yasushi Yamasaki, Toshihiro Inokuchi, Hideaki Kinugasa, Masahiro Takahara, Sakiko Hiraoka, Hiroyuki Okada

{"title":"Low Patient Weight and Long Intubation Time Are Key Factors for Pain during Colonoscopy.","authors":"Shohei Oka, Keita Harada, Shumpei Yamamoto, Eriko Yasutomi, Shoko Igawa, Masayasu Ohmori, Mami Hirai, Yasushi Yamasaki, Toshihiro Inokuchi, Hideaki Kinugasa, Masahiro Takahara, Sakiko Hiraoka, Hiroyuki Okada","doi":"10.18926/AMO/65969","DOIUrl":"https://doi.org/10.18926/AMO/65969","url":null,"abstract":"Although the clinical usefulness of colonoscopy has been established, the procedure remains painful for many patients. This study was designed to clarify the factors predicting colonoscopy-related pain. We evaluated 283 consecutive patients who completed a first-ever, total colonoscopy without sedatives or analgesics. The severity of pain symptoms was evaluated by a numeric rating scale (NRS) in a questionnaire immediately after the colonoscopy. Patient backgrounds and endoscopic findings were analyzed to evaluate their association with pain. Out of 283 patients, 53 scored their pain 0-1 on the NRS while 48 scored it 6-10. We defined the colonoscopies of the former and latter patients as painless and painful, respectively, and compared the two. Multivariate analyses revealed that low body weight (OR 4.95, 95%CI 1.89-12.99) and longer intubation time (OR 3.63, 95%CI 1.46-9.03) were significant risk factors for painful colonoscopy. To identify factors contributing to the increased intubation time, we divided subjects into short- and long-intubation-time groups based on a median insertion time of 7 min. Older age (OR 2.28, 95%CI 1.31-3.98), previous abdominal surgery (OR 1.93, 95%CI 1.13-3.32) and findings of invasive cancer (OR 10.90, 95%CI 1.34-88.90) were significant factors for longer intubation time.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"77 5","pages":"471-478"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological Analysis Based on the Terminal End of the Spinal Cord and the Narrowest Level of Injured Spine in Thoracolumbar Spinal Injuries. 基于胸腰椎损伤脊髓末端和损伤脊柱最窄水平的神经学分析。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-10-01 DOI: 10.18926/AMO/65972

Yuji Hatakeyama, Michio Hongo, Tadato Kido, Masakazu Urayama, Yuji Kasukawa, Hiroshi Sasaki, Toshiaki Aizawa, Daisuke Kudo, Ryota Kimura, Yuichi Ono, Fumihito Kasama, Naohisa Miyakoshi

{"title":"Neurological Analysis Based on the Terminal End of the Spinal Cord and the Narrowest Level of Injured Spine in Thoracolumbar Spinal Injuries.","authors":"Yuji Hatakeyama, Michio Hongo, Tadato Kido, Masakazu Urayama, Yuji Kasukawa, Hiroshi Sasaki, Toshiaki Aizawa, Daisuke Kudo, Ryota Kimura, Yuichi Ono, Fumihito Kasama, Naohisa Miyakoshi","doi":"10.18926/AMO/65972","DOIUrl":"https://doi.org/10.18926/AMO/65972","url":null,"abstract":"This study aimed to clarify neurological differences among the epiconus, conus medullaris, and cauda equina syndromes. Eighty-seven patients who underwent surgery for acute thoracolumbar spinal injuries were assessed. We defined the epiconus as the region from the terminal end of the spinal cord to the proximal 1.0 to 2.25 vertebral bodies, the conus medullaris as the region proximal to < 1.0 vertebral bodies, and the cauda equina as the distal part of the nerve roots originating from the spinal cord. On the basis of the distance from the terminal end of the spinal cord to the narrowest level of the spinal canal, the narrowest levels were ordered as follows: the epiconus followed by the conus medullaris and cauda equina. The narrowest levels were the epiconus in 22 patients, conus medullaris in 37 patients, and cauda equina in 25 patients. On admission, significantly more patients had a narrowed epiconus of Frankel grades A-C than a narrowed cauda equina. At the final follow-up, there were no significant differences in neurological recovery among those with epiconus, conus medullaris, or cauda equina syndrome. Anatomically classifying the narrowest lesion is useful for clarifying the differences and similarities among these three syndromes.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"77 5","pages":"499-509"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of Intraoperative SpO2 and ETCO2 Values with Postoperative Hypoxemia in Elderly Patients after Non-Cardiac Surgery. 老年患者非心脏手术后术中SpO2和ETCO2值与术后低氧血症的关系。

IF 0.5 4区医学

Acta medica Okayama Pub Date : 2023-10-01 DOI: 10.18926/AMO/65976

Qingqing Song, Yu Pan, Tomoyuki Kanazawa, Hiroshi Morimatsu

{"title":"Relationship of Intraoperative SpO2 and ETCO2 Values with Postoperative Hypoxemia in Elderly Patients after Non-Cardiac Surgery.","authors":"Qingqing Song, Yu Pan, Tomoyuki Kanazawa, Hiroshi Morimatsu","doi":"10.18926/AMO/65976","DOIUrl":"https://doi.org/10.18926/AMO/65976","url":null,"abstract":"Elderly patients are at higher risk of postoperative hypoxemia due to their decreased respiratory function. The aim of this study was to investigate the relationship of intraoperative oxygen saturation (SpO2) and end-expiratory carbon dioxide (ETCO2) values with postoperative hypoxemia in elderly patients. The inclusion criteria were: 1) patients aged≥75 years; 2) underwent general anesthesia in non-cardiac surgery; 3) operative time longer than two hours; and 4) admission to the intensive care unit (ICU) following surgery performed between January and December 2019. Intraoperative SpO2 and ETCO2 values were collected every minute for the first two hours during surgery. The 253 patients were divided into two groups: SpO2≥92% and SpO2<92%. The time-weighted averages of intraoperative SpO2 and ETCO2 were used to compare differences between the two groups. The incidence of postoperative hypoxemia was 22.5%. For similar ventilator settings, patients with postoperative hypoxemia had lower intraoperative SpO2 and higher ETCO2 values. Sex, ASA classification, and intraoperative SpO2 were independent risk factors for postoperative hypoxemia. In conclusion, postoperative SpO2<92% was a frequent occurrence (> 20%) in elderly patients who underwent major non-cardiac surgery. Postoperative hypoxemia was associated with low intraoperative SpO2 and relatively higher ETCO2.","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"77 5","pages":"537-543"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0