Acta medica Okayama最新文献

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Reducing Hesitation in Resuscitation: Educational Effects of a Female-Appearing Simulator in Basic Life Support Training. 减少复苏时的犹豫:女性出现模拟器在基本生命维持训练中的教育作用。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-06-01 DOI: 10.18926/AMO/70854
Takuya Kubo, Kohei Tsukahara, Takashi Hongo, Takafumi Obara, Yoshinori Kosaki, Tsuyoshi Nojima, Tetsuya Yumoto, Hiromichi Naito, Atsunori Nakao
{"title":"Reducing Hesitation in Resuscitation: Educational Effects of a Female-Appearing Simulator in Basic Life Support Training.","authors":"Takuya Kubo, Kohei Tsukahara, Takashi Hongo, Takafumi Obara, Yoshinori Kosaki, Tsuyoshi Nojima, Tetsuya Yumoto, Hiromichi Naito, Atsunori Nakao","doi":"10.18926/AMO/70854","DOIUrl":"https://doi.org/10.18926/AMO/70854","url":null,"abstract":"<p><p>Women are less likely than men to receive timely defibrillation during out-of-hospital cardiac arrest. We investigated whether using a simulator that is visually modified to resemble a female affects learners' attitudes, knowledge, and performance in basic life support (BLS) training. In a BLS simulation training, first-year medical students (n=220) used a standard gender-neutral simulator (control group) or a modified simulator with a female-like appearance (intervention group). Pre- and post-training questionnaires concerning attitudes and knowledge plus a post-training skills evaluation assessed the students' training outcomes. The intervention group initiated chest compressions significantly faster than the control group (33.1 vs. 39.8 sec, p<0.01) and achieved a significantly higher rate of correct AED pad placement (64.2% vs. 38.5%, p<0.01). While performing the resuscitation on the female-appearing manikin, the intervention group showed significantly greater increases in self-efficacy (p<0.01) and larger decreases in discomfort about removing the patient's clothes (p<0.01). They were also significantly more likely to recognize that chest compressions can be performed (p=0.016) and AED pads can be applied (p=0.015) without removing the patient's underwear. Using a female-appearing simulator in BLS training was thus associated with faster chest compression initiation, more accurate AED pad placement, and improved gender-sensitive attitudes and knowledge.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 3","pages":"185-193"},"PeriodicalIF":0.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Eicosapentaenoic Acid and Paclitaxel-Associated Peripheral Neuropathy: A Retrospective Study at Okayama University Hospital. 口服二十碳五烯酸与紫杉醇相关周围神经病变:冈山大学医院的回顾性研究。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-06-01 DOI: 10.18926/AMO/70853
Ayako Morita, Hideki Katayama, Eiki Ichihara, Yoshinobu Maeda
{"title":"Oral Eicosapentaenoic Acid and Paclitaxel-Associated Peripheral Neuropathy: A Retrospective Study at Okayama University Hospital.","authors":"Ayako Morita, Hideki Katayama, Eiki Ichihara, Yoshinobu Maeda","doi":"10.18926/AMO/70853","DOIUrl":"https://doi.org/10.18926/AMO/70853","url":null,"abstract":"<p><p>This retrospective study investigated whether eicosapentaenoic acid (EPA) reduces paclitaxel-associated chemotherapy-induced peripheral neuropathy (CIPN) and acute neuropathic pain in dyslipidemic cancer patients. The medical records of cancer patients treated with paclitaxel or nab-paclitaxel at Okayama University Hospital between January 2018 and December 2022 were reviewed. Patients receiving concomitant therapy for dyslipidemia were categorized as EPA users or non-EPA users. Numbness and pain severity were extracted from medical records. The primary endpoint was the change from baseline in Common Terminology Criteria for Adverse Events (CTCAE) grade for peripheral neuropathy and pain; groups were analyzed using the Mann-Whitney U test. Of 184 eligible patients, 18 received EPA. Bleeding events were more frequent in the EPA group; however, changes in numbness and pain did not differ significantly between groups at any time point. Overall, EPA did not show a preventive effect on paclitaxel-associated CIPN or acute neuropathic pain. Future studies should evaluate EPA in combination with other neuroprotective agents to better define its potential role in CIPN prevention.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 3","pages":"179-184"},"PeriodicalIF":0.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-Reported Adolescent Menstrual Symptoms and Delayed Gynecologic Consultation among Japanese Women with Endometriosis. 日本子宫内膜异位症女性自我报告的青春期月经症状和延迟的妇科咨询。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-06-01 DOI: 10.18926/AMO/70851
Tomoko Ikeda, Mikiya Nakatsuka
{"title":"Self-Reported Adolescent Menstrual Symptoms and Delayed Gynecologic Consultation among Japanese Women with Endometriosis.","authors":"Tomoko Ikeda, Mikiya Nakatsuka","doi":"10.18926/AMO/70851","DOIUrl":"https://doi.org/10.18926/AMO/70851","url":null,"abstract":"<p><p>Endometriosis symptoms often first appear during adolescence, yet delays in seeking gynecologic consultation remain a persistent challenge worldwide. Despite growing international evidence, the specific patterns of symptom recognition and consultation delay among Japanese women - particularly in relation to self-monitoring behaviors and cultural barriers - remain poorly understood. This study aimed to provide foundational data to guide menstrual education and preconception care strategies by conducting a cross-sectional online survey with retrospective recall among women with endometriosis to assess menstrual characteristics and symptom patterns from adolescence to initial care seeking. The survey was conducted in Japan in January 2024 and enrolled 166 women with endometriosis and 200 controls. Participants reported current and adolescent menstrual characteristics, symptom recognition, analgesic and low-dose estrogen-progestin use, school/work impact, and age at first gynecologic consultation for menstrual problems. Women with endometriosis reported heavier bleeding, stronger pain, and greater school/work absence than controls, both currently and retrospectively. The median age at first recognition of heavy bleeding or school/work absence was 16 years, whereas consultation occurred at approximately 21-23 years, indicating a consultation delay of 5-6 years. Notably, while self-monitoring of symptoms was more frequent among women with endometriosis, it only modestly shortened consultation delays. This study provides evidence from Japan that consultation delay persists despite active self-monitoring of symptoms, highlighting the influence of educational and cultural barriers on health-seeking behavior. These findings underscore the importance of integrating menstrual education with clinical guidance to promote timely gynecologic consultation.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 3","pages":"159-168"},"PeriodicalIF":0.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral Blood T-Cell Receptor Repertoire and Host Immune Background in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy. 接受新辅助化疗的乳腺癌患者外周血t细胞受体库和宿主免疫背景。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-06-01 DOI: 10.18926/AMO/70852
Yuki Nakamura, Takayuki Iwamoto, Yukiko Kajiwara, Akira Hida, Shogo Nakamoto, Yuichiro Miyoshi, Tadahiko Shien, Masahiko Ikeda, Hiroyoshi Doihara, Ryohei Ogata, Yoshikazu Koike, Tsunehisa Nomura, Katsuhiro Tanaka, Kazutaka Nakashima, Tomoki Yamatsuji, Naruto Taira
{"title":"Peripheral Blood T-Cell Receptor Repertoire and Host Immune Background in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.","authors":"Yuki Nakamura, Takayuki Iwamoto, Yukiko Kajiwara, Akira Hida, Shogo Nakamoto, Yuichiro Miyoshi, Tadahiko Shien, Masahiko Ikeda, Hiroyoshi Doihara, Ryohei Ogata, Yoshikazu Koike, Tsunehisa Nomura, Katsuhiro Tanaka, Kazutaka Nakashima, Tomoki Yamatsuji, Naruto Taira","doi":"10.18926/AMO/70852","DOIUrl":"https://doi.org/10.18926/AMO/70852","url":null,"abstract":"<p><p>The association between peripheral blood T-cell receptor (TCR) repertoire and chemotherapy response remains unclear. We evaluated peripheral blood TCR repertoire and gut microbiota in 21 breast cancer patients receiving neoadjuvant chemotherapy (NAC) who were enrolled in the SBP-14 prospective cohort study between October 2019 and March 2022. We analyzed stool samples obtained pre-NAC and peripheral blood samples obtained pre- and post-NAC. The primary endpoint was the association between baseline peripheral blood TCR repertoire and treatment response. Eleven patients (52%) had hormone receptor-positive breast cancer. All patients received anthracyclines and taxanes, with anti-HER2 therapy for HER2-positive disease. TCR diversity (TCR alpha chain [TRA], p=0.095; TCR beta chain [TRB], p=0.051) and clonality (TRA, p=0.271; TRB, p=0.500) were not significantly associated with treatment response. Gut microbiota diversity was not correlated with TCR diversity (TRA: ρ=0.046, p=0.845; TRB: ρ=0.021, p=0.929); however, three bacterial orders (Erysipelotrichales, Bacillales, and Pasteurellales) were significantly associated with TCR repertoire. Baseline TCR repertoire was not associated with treatment response in this cohort of breast cancer patients.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 3","pages":"169-178"},"PeriodicalIF":0.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of the Side Responsible for Bilateral Pneumothorax due to Pleural Communication. 胸膜沟通导致双侧气胸的原因的确定。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-06-01 DOI: 10.18926/AMO/70859
Ken Suzawa, Haruchika Yamamoto, Kumi Nakajima, Shin Tanaka, Hidejiro Torigoe, Kazuhiko Shien, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka
{"title":"Determination of the Side Responsible for Bilateral Pneumothorax due to Pleural Communication.","authors":"Ken Suzawa, Haruchika Yamamoto, Kumi Nakajima, Shin Tanaka, Hidejiro Torigoe, Kazuhiko Shien, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka","doi":"10.18926/AMO/70859","DOIUrl":"https://doi.org/10.18926/AMO/70859","url":null,"abstract":"<p><p>Simultaneous bilateral spontaneous pneumothorax associated with pleuro-pleural communication is a rare but potentially life-threatening condition, most commonly occurring after major thoracic surgery. We report the case of an 81-year-old man with severe emphysema and a history of esophagectomy who presented with sudden-onset dyspnea. Chest computed tomography revealed bilateral pneumothorax with pleuro-pleural communication. Although bilateral chest tube drainage was performed, the primary side of air leakage could not be identified preoperatively. After induction of general anesthesia, a double-lumen endotracheal tube clamping test identified the right pleural cavity as the source of air leakage, thereby enabling appropriate thoracoscopic surgery.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 3","pages":"225-228"},"PeriodicalIF":0.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Bone Mineral Density and Bone Structure in the Cervical and Thoracic Spine. 评价颈椎和胸椎的骨密度和骨结构。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-06-01 DOI: 10.18926/AMO/70856
Shingo Aoyama, Terumasa Ikeda, Nobuhito Nango, Koji Goto
{"title":"Evaluation of Bone Mineral Density and Bone Structure in the Cervical and Thoracic Spine.","authors":"Shingo Aoyama, Terumasa Ikeda, Nobuhito Nango, Koji Goto","doi":"10.18926/AMO/70856","DOIUrl":"https://doi.org/10.18926/AMO/70856","url":null,"abstract":"<p><p>Dropped head syndrome, which has been increasingly reported in recent years, requires correction of cervical kyphosis and may require long-range fixation extending from the cervical to the thoracic spine. Assessing vertebral bone structure may be important for preventing instrumentation failure in the upper thoracic spine, which is a potential complication of surgery. In this study, we evaluated volumetric bone mineral density, trabecular bone porosity, and cortical calcification in the cervical and upper thoracic spine using three-dimensional (3D) trabecular structure measurement software. The study included 79 patients with cervical spine disorders who underwent various surgical procedures and preoperative imaging, including dual-energy X-ray absorptiometry and computed tomography (CT) scans from C3 to Th3. Quantitative analysis using specialized software assessed volumetric bone mineral density and trabecular and cortical bone parameters, and statistical analyses were performed to examine correlations between imaging metrics and indicators of bone fragility. Two-dimensional CT evaluation revealed different trends between cancellous and cortical bone in the cervical and thoracic spine, suggesting that detailed 3D evaluation may also be important.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 3","pages":"203-212"},"PeriodicalIF":0.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting Adrenal Crisis Triggered by Influenza Infection: Lessons from Two Fatal Cases. 重新审视流感感染引发的肾上腺危机:两个致命病例的教训。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70458
Yoshiyuki Ueda, Tetsuya Yumoto, Takashi Hongo, Takafumi Obara, Tsuyoshi Nojima, Kohei Tsukahara, Kosei Hasegawa, Natsuko Futagawa, Hiromichi Naito, Atsunori Nakao
{"title":"Revisiting Adrenal Crisis Triggered by Influenza Infection: Lessons from Two Fatal Cases.","authors":"Yoshiyuki Ueda, Tetsuya Yumoto, Takashi Hongo, Takafumi Obara, Tsuyoshi Nojima, Kohei Tsukahara, Kosei Hasegawa, Natsuko Futagawa, Hiromichi Naito, Atsunori Nakao","doi":"10.18926/AMO/70458","DOIUrl":"10.18926/AMO/70458","url":null,"abstract":"<p><p>Adrenal crisis is a life-threatening endocrine emergency that can progress within hours despite a prior diagnosis and maintenance therapy. We describe a fatal influenza-triggered adrenal crisis in two patients: a child with panhypopituitarism and an adult with prior pituitary surgery, both presenting in cardiac arrest. Despite resuscitation and intravenous hydrocortisone, a fatal hypoxic-ischemic injury or multiorgan failure occurred. These cases highlight the fulminant course of an adrenal crisis and underscore the importance of early recognition, clinician awareness, prompt parenteral hydrocortisone administration, and reinforcement of education for patients, caregivers, and healthcare providers to improve preparedness and prevent avoidable deaths.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"153-157"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consistent Clinical Outcomes of Anteroinferior Minimally Invasive Plate Osteosynthesis for Midshaft Clavicle Fractures Across AO/OTA Fracture Types. 前下微创钢板内固定治疗锁骨中轴骨折AO/OTA骨折类型的一致性临床结果
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70452
Nguyen Trung Thanh, Ryo Nakamichi, Yasunori Shimamura, Taichi Saito, Takeshi Ishihara, Tomoki Furutani, Hisakazu Shitozawa, Tomoyuki Noda, Toshifumi Ozaki
{"title":"Consistent Clinical Outcomes of Anteroinferior Minimally Invasive Plate Osteosynthesis for Midshaft Clavicle Fractures Across AO/OTA Fracture Types.","authors":"Nguyen Trung Thanh, Ryo Nakamichi, Yasunori Shimamura, Taichi Saito, Takeshi Ishihara, Tomoki Furutani, Hisakazu Shitozawa, Tomoyuki Noda, Toshifumi Ozaki","doi":"10.18926/AMO/70452","DOIUrl":"10.18926/AMO/70452","url":null,"abstract":"<p><p>Although the performance of minimally invasive plate osteosynthesis (MIPO) via the anteroinferior approach is increasingly adopted for midshaft clavicle fractures, the influence of fracture morphology on clinical outcomes under a standardized protocol is unclear. We retrospectively analyzed the cases of 54 patients who underwent anteroinferior MIPO for an acute midshaft clavicle fracture (AO/OTA types B1, B2, B3) performed by a single surgeon across three affiliated institutions (2009-2022). We evaluated the clinical outcomes, i.e., the surgical time, incision length, radiographic union, reduction accuracy, range of motion, pain (visual analog scale [VAS]), and complications and compared them among the three AO/OTA subtypes. The mean incision length (3.4 cm) and surgical time (71-79 min) were similar among the groups (both p>0.2). All fractures achieved radiographic union at a mean of 3.5 months. Postoperative alignment and clavicular length were maintained (length reduction -1.0±2.2 mm [B1], -0.5±2.0 mm [B2], -0.6±1.8 mm [B3]; p=0.825; angulation -0.8±3.4°, -1.1±3.1°, -0.3±3.3°; p=0.888). At 3 months, shoulder elevation and abduction were 169°-175° (p=0.079) and 164°-175° (p=0.324). Pain was minimal (100-mm VAS: ≤1 mm; p=0.782). One plate-fatigue failure occurred; no supraclavicular-nerve symptoms were recorded. Anteroinferior MIPO yielded consistent outcomes across AO/OTA types, with excellent union rates, functional recovery, and few complications, indicating that this technique is safe and reproducible for the surgical management of midshaft clavicle fractures.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"99-107"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients. 老年骨质疏松性胸腰椎塌陷的小开口椎体切除术及侧卧位单体位后路脊柱固定。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70454
Hisanori Ikuma, Tomohiko Hirose, Keisuke Kawasaki, Kazutoshi Otsuka
{"title":"Mini-open Corpectomy and Posterior Spinal Fixation with Single-Position Surgery in Lateral Decubitus Position for Osteoporotic Thoracolumbar Vertebral Collapse in Elderly Patients.","authors":"Hisanori Ikuma, Tomohiko Hirose, Keisuke Kawasaki, Kazutoshi Otsuka","doi":"10.18926/AMO/70454","DOIUrl":"10.18926/AMO/70454","url":null,"abstract":"<p><p>We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in the lateral decubitus position in patients aged > 75 years with thoracolumbar vertebral collapse. The cases of 30 consecutive patients who underwent this procedure and had ≥ 1-year follow-up were retrospectively analyzed. The mean operative time was 78.8 min and the estimated blood loss was 115.7 ml per level. The complications included adjacent junctional failure (n=9, 30%), deep venous thrombosis (n=3, 10%), delirium (n=3, 10%), pleural injury (n=2, 6%), screw backout (n=1, 3%) kidney injury (n=1, 3%), chylothorax (n=1, 3%), and wound dehiscence (n=1, 3%). Seven cases (23.3%) required reoperation. Local kyphosis showed significant improvement (p<0.05) that was maintained at the final follow-up. The Japanese Orthopaedic Association Back Pain Evaluation Questionnaire and a visual analogue scale indicated significant improvement in all categories at the final follow-up (p<0.05). The use of mini-open corpectomy and posterior fixation with SPAPS can thus provide reliable radiological correction and good postoperative clinical outcomes even in patients aged > 75 years. However, a limitation of this procedure is the rate of reoperation (23.3%) for osteoporosis-related adjacent segment fracture and screw backout.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"119-129"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Nonsurgical Periodontal Treatment on Bacterial and Clinical Parameters in Down Syndrome Patients Based on 16S rRNA Gene Amplicon Sequencing. 基于16S rRNA基因扩增子测序的牙周非手术治疗对唐氏综合征患者细菌及临床参数的影响
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70451
Takahiko Shiba, Mitsuhito Takamori, Sayaka Katagiri, Ryota Kobayashi, Aki Kawauchi, Yujin Ohsugi, Peiya Lin, Daisuke Ekuni, Masahiko Egusa, Takanori Iwata, Shigeru Maeda
{"title":"Effects of Nonsurgical Periodontal Treatment on Bacterial and Clinical Parameters in Down Syndrome Patients Based on 16S rRNA Gene Amplicon Sequencing.","authors":"Takahiko Shiba, Mitsuhito Takamori, Sayaka Katagiri, Ryota Kobayashi, Aki Kawauchi, Yujin Ohsugi, Peiya Lin, Daisuke Ekuni, Masahiko Egusa, Takanori Iwata, Shigeru Maeda","doi":"10.18926/AMO/70451","DOIUrl":"10.18926/AMO/70451","url":null,"abstract":"<p><p>Individuals with Down syndrome (DS) are more susceptible to periodontal disease; however, microbial changes following treatment remain insufficiently understood. This study evaluated the effects of nonsurgical periodontal therapy on clinical outcomes and oral microbiome dynamics in 6 patients with DS using 16S rRNA gene amplicon sequencing. Bacterial diversity, composition, network structure, and predicted functional pathways were analyzed using dental plaque samples. Bleeding on probing decreased significantly (p=0.047) after treatment, with a trend toward reduction in periodontal inflamed surface area (p=0.05). The abundance of Fusobacteria at the class level decreased significantly after treatment. The abundance of Mogibacterium timidum was higher in the pretreatment group than in the posttreatment group. M. timidum was positively correlated with Treponema denticola and associated with multiple bacterial taxa in the network during pretreatment. Predicted functional pathways related to aromatic compound degradation were more abundant in posttreatment samples than in pretreatment samples. An increase in the abundance of Fusobacterium and the positive correlation between T. denticola and M. timidum, together with their associations with other periodontal pathogens before treatment, may contribute to the development of periodontitis in individuals with DS. Nonsurgical periodontal therapy produces measurable clinical improvement and promotes microbial shifts in patients with DS.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"85-97"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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