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A Rare Presentation of Pneumonic-Type Adenocarcinoma Hidden behind Empyema. 一罕见的藏在脓胸后面的肺型腺癌。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69158
Satoru Senoo, Eito Niman, Ryoko Tsuji, Kohei Takata, Shunsuke Matsumori, Fumika Murano, Yuka Sugisaki, Hiroki Omori, Akihiko Taniguchi, Rika Omote, Eiki Ichihara, Kenji Takahashi, Toshiaki Okada
{"title":"A Rare Presentation of Pneumonic-Type Adenocarcinoma Hidden behind Empyema.","authors":"Satoru Senoo, Eito Niman, Ryoko Tsuji, Kohei Takata, Shunsuke Matsumori, Fumika Murano, Yuka Sugisaki, Hiroki Omori, Akihiko Taniguchi, Rika Omote, Eiki Ichihara, Kenji Takahashi, Toshiaki Okada","doi":"10.18926/AMO/69158","DOIUrl":"https://doi.org/10.18926/AMO/69158","url":null,"abstract":"<p><p>Pneumonic-type adenocarcinoma (P-ADC) can closely mimic pneumonia. We report a P-ADC initially diagnosed as pneumonia which developed into a pulmonary abscess and empyema. A 50-year-old Japanese male diagnosed with pneumonia, pulmonary abscess, and empyema was administered antibiotics and a chest tube for drainage, which improved his symptoms and blood test results. However, chest computed tomography showed an enlarged infiltrative shadow. The patient underwent bronchoscopy and was diagnosed with an adenocarcinoma. This case highlights the importance of considering P-ADC in differential diagnoses when a pneumonia-like shadow enlarges post-empyema treatment. Diagnostic and clinical tests, e.g., bronchoscopy, should be performed in such cases.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 4","pages":"305-309"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcome of Decompression Surgery Following Rapid Neurological Deterioration in Patients with Spinal Cord Injury Without Radiographic Evidence of Trauma (SCIWORET). 无放射学创伤证据的脊髓损伤患者神经功能迅速恶化后减压手术的结果。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69151
Yuichi Hirata, Chiaki Sugahara, Susumu Sasada, Hayato Miyake, Takayuki Nagase, Takao Yasuhara, Shota Tanaka
{"title":"Outcome of Decompression Surgery Following Rapid Neurological Deterioration in Patients with Spinal Cord Injury Without Radiographic Evidence of Trauma (SCIWORET).","authors":"Yuichi Hirata, Chiaki Sugahara, Susumu Sasada, Hayato Miyake, Takayuki Nagase, Takao Yasuhara, Shota Tanaka","doi":"10.18926/AMO/69151","DOIUrl":"https://doi.org/10.18926/AMO/69151","url":null,"abstract":"<p><p>Cervical spondylotic myelopathy (CSM) and ossification of the posterior longitudinal ligament (OPLL) increase the likelihood of spinal cord injury without radiographic evidence of trauma (SCIWORET). Opinions regarding the optimal timing for surgery in such cases vary, however. We retrospectively investigated the demographics and outcomes of patients with SCIWORET who underwent surgery shortly after experiencing rapid neurological deterioration, and we matched patients who underwent standby surgery for CSM or OPLL. Although the optimal timing of surgery for SCIWORET remains unclear, our findings suggest that early stage surgery for SCIWORET may yield favorable neurological improvements.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 4","pages":"261-267"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Work Productivity of Cancer-survivor and Non-cancer-survivor Workers. 癌症幸存者和非癌症幸存者的工作效率。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69149
Mika Kamano, Kanae Kanda, Nlandu Roger Ngatu, Akitsu Murakami, Yusuke Yamadori, Tomohiro Hirao
{"title":"The Work Productivity of Cancer-survivor and Non-cancer-survivor Workers.","authors":"Mika Kamano, Kanae Kanda, Nlandu Roger Ngatu, Akitsu Murakami, Yusuke Yamadori, Tomohiro Hirao","doi":"10.18926/AMO/69149","DOIUrl":"https://doi.org/10.18926/AMO/69149","url":null,"abstract":"<p><p>We investigated the work productivity levels of employed cancer survivors and non-cancer-survivor workers by conducting a cross-sectional study in Japan between February and March 2019, using an online survey. A total of 561 employed individuals aged 20-64 years were analyzed. Work productivity was assessed using the Work Productivity and Activity Impairment-General Health questionnaire which evaluates absenteeism, presenteeism, and overall work productivity loss. The questionnaire responses demonstrated that the cancer survivors within 1 year of diagnosis had significantly higher absenteeism compared to the non-cancer workers (p=0.048). Although presenteeism and overall work productivity loss were also higher in the non-cancer-survivor group, the differences were not significant. Cancer survivors within 1 year of diagnosis exhibited higher absenteeism, but their work productivity appeared to recover to levels comparable to those of the non-cancer workers over time. These findings may contribute to workplace policies supporting cancer survivors' return to work.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 4","pages":"243-251"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Calcium Phosphate Cement Embolism After Percutaneous Vertebroplasty for Thoracic Vertebrae Fractures. 胸椎骨折经皮椎体成形术后肺磷酸钙水泥栓塞。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-08-01 DOI: 10.18926/AMO/69157
Ruibin Feng, Bikang Zhu, Danyun Wei, Dingjiao Zhu, Cairu Chen
{"title":"Pulmonary Calcium Phosphate Cement Embolism After Percutaneous Vertebroplasty for Thoracic Vertebrae Fractures.","authors":"Ruibin Feng, Bikang Zhu, Danyun Wei, Dingjiao Zhu, Cairu Chen","doi":"10.18926/AMO/69157","DOIUrl":"https://doi.org/10.18926/AMO/69157","url":null,"abstract":"<p><p>Pulmonary cement embolism (PCE) is a rare but severe complication following percutaneous vertebroplasty (PVP). Calcium phosphate cement (CPC) has emerged as an alternative to traditional materials for vertebral augmentation. There appear to be no established guidelines for managing symptomatic PCE, and there is scarce literature on CPC embolisms. This is a first report of a case of pulmonary CPC embolism following PVP. The patient, a 63-year-old Chinese female, was administered anticoagulant treatment and achieved a satisfactory outcome. Her case highlights the severe potential morbidity associated with CPC leakage and emphasizes the efficacy of anticoagulant treatment for managing pulmonary CPC embolisms.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 4","pages":"299-303"},"PeriodicalIF":0.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Aniline Poisoning Manifesting as Cyanosis with Unknown Cause. 苯胺中毒表现为不明原因的发绀1例。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68729
Kenichi Taguchi, Kazuya Nishii, Sakura Hata, Shoichi Kuyama, Shoichi Tanaka
{"title":"A Case of Aniline Poisoning Manifesting as Cyanosis with Unknown Cause.","authors":"Kenichi Taguchi, Kazuya Nishii, Sakura Hata, Shoichi Kuyama, Shoichi Tanaka","doi":"10.18926/AMO/68729","DOIUrl":"https://doi.org/10.18926/AMO/68729","url":null,"abstract":"<p><p>A 38-year-old man was brought to the hospital for emergency treatment of cyanosis. The patient exhibited generalized cyanosis and impaired consciousness despite adequate oxygen therapy. Arterial blood was black, and arterial blood gas analysis revealed an abnormally high methemoglobin level of 67.8%. We later interviewed his colleagues regarding his exposure to aniline while working at the factory and diagnosed him with methemoglobinemia due to aniline poisoning. The patient was administered methylene blue (MB) after being transferred to another hospital, where this treatment was available, resulting in an improvement in symptoms. Although rare, methemoglobinemia is serious. A good understanding of the circumstances at disease onset, characteristic findings, and abnormal values of methemoglobinemia is important. In addition, MB is an important therapeutic for the treatment of methemoglobinemia; if MB is not available at a particular hospital, transfer of the patient to a hospital that stocks MB should be considered.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"209-212"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Asymptomatic Perigraft Seroma in a Patient who Underwent Aortic Root Replacement for Annulo-Aortic Ectasia. 一例因主动脉瓣扩张而行主动脉根置换术的无症状周围膜瘤。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68728
Yasufumi Fujita, Shuji Shimizu
{"title":"An Asymptomatic Perigraft Seroma in a Patient who Underwent Aortic Root Replacement for Annulo-Aortic Ectasia.","authors":"Yasufumi Fujita, Shuji Shimizu","doi":"10.18926/AMO/68728","DOIUrl":"10.18926/AMO/68728","url":null,"abstract":"<p><p>Perigraft seroma, a sterile fluid accumulation around the graft, is a potential complication after thoracic aortic surgery. The optimal treatment strategy for a perigraft seroma with vascular compression after thoracic aortic surgery has been unclear. We describe the case of a 62-year-old Japanese male in whom an asymptomatic perigraft seroma was observed after he had undergone aortic root replacement for annulo-aortic ectasia. The seroma was successfully treated with thoracoscopic drainage and conservative therapy. Less invasive therapy, including conservative therapy, may also be an option for asymptomatic perigraft seromas observed after thoracic aortic surgery.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"205-208"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunometabolic Regulation of Innate Immunity in Systemic Lupus Erythematosus. 系统性红斑狼疮先天免疫的免疫代谢调节。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68722
Haruki Watanabe, Yoshinori Matsumoto, Jun Wada
{"title":"Immunometabolic Regulation of Innate Immunity in Systemic Lupus Erythematosus.","authors":"Haruki Watanabe, Yoshinori Matsumoto, Jun Wada","doi":"10.18926/AMO/68722","DOIUrl":"https://doi.org/10.18926/AMO/68722","url":null,"abstract":"<p><p>Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to \"training\" for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"147-155"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Cup Placement Position in Total Hip Arthroplasty with Cup-side Implant Placement in Computed Tomography Horizontal Sections. 全髋关节置换术中杯侧置入术杯位的计算机断层水平切片研究。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68725
Shuro Furuichi, Shigeru Mitani, Hirosuke Endo, Yoshifumi Namba, Toyohiro Kawamoto
{"title":"Investigation of Cup Placement Position in Total Hip Arthroplasty with Cup-side Implant Placement in Computed Tomography Horizontal Sections.","authors":"Shuro Furuichi, Shigeru Mitani, Hirosuke Endo, Yoshifumi Namba, Toyohiro Kawamoto","doi":"10.18926/AMO/68725","DOIUrl":"https://doi.org/10.18926/AMO/68725","url":null,"abstract":"<p><p>The position attained in total hip arthroplasty (THA) is ideally in the center of the horizontal plane of the acetabulum. However, central placement is not always possible. We hypothesized that differences in approach result in individual differences in cup positioning; thus, we investigated the cup positions of 217 hips that underwent THA. The acetabulum's anteroposterior diameter was measured, and the cups placed within 2 mm of the line perpendicular to the center as a central placement (central). Of the 217 hips, 68, 114, and 35 hips were anterior, central, and posterior, respectively. In 21 hips, anteroposterior deviation was noted. Among patients operated using the anterolateral approach, 48, 93, and 30 hips were anterior, central, and posterior, respectively. Among those operated using the posterolateral approach, 16, 20, and 4 hips were anterior, central, and posterior, respectively. The cup position shifted either anteriorly or posteriorly to the acetabulum in approximately half of all hips operated using both approaches and tended to shift anteriorly in the hips operated using the posterolateral approach. During THA surgery, it is important to operate with awareness of the center of the acetabulum.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"177-184"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Stimulation with Glycolaldehyde-derived Advanced Glycation End Product Reduces Aggrecan and COL2A1 Production via RAGE in Human OUMS-27 Chondrosarcoma Cells. 持续刺激乙醇醛衍生的晚期糖基化终产物通过RAGE减少人OUMS-27软骨肉瘤细胞中聚集蛋白和COL2A1的产生
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68723
Omer Faruk Hatipoglu, Takashi Nishinaka, Kursat Oguz Yaykasli, Shuji Mori, Masahiro Watanabe, Takao Toyomura, Masahiro Nishibori, Satoshi Hirohata, Hideo Takahashi, Hidenori Wake
{"title":"Continuous Stimulation with Glycolaldehyde-derived Advanced Glycation End Product Reduces Aggrecan and COL2A1 Production via RAGE in Human OUMS-27 Chondrosarcoma Cells.","authors":"Omer Faruk Hatipoglu, Takashi Nishinaka, Kursat Oguz Yaykasli, Shuji Mori, Masahiro Watanabe, Takao Toyomura, Masahiro Nishibori, Satoshi Hirohata, Hideo Takahashi, Hidenori Wake","doi":"10.18926/AMO/68723","DOIUrl":"https://doi.org/10.18926/AMO/68723","url":null,"abstract":"<p><p>Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"157-166"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Chromophobe Renal Cell Carcinoma Metastasizing to the Cervical Lymph Nodes after Long-term Follow-up. 长期随访后憎色性肾细胞癌转移至颈部淋巴结1例。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2025-06-01 DOI: 10.18926/AMO/68730
Makoto Watanabe, Tomoyuki Ogawa, Kanao Kobayashi, Narutaka Katsuya, Akira Ishikawa, Takao Hamamoto, Hiroaki Tahara, Tsutomu Ueda, Sachio Takeno
{"title":"A Case of Chromophobe Renal Cell Carcinoma Metastasizing to the Cervical Lymph Nodes after Long-term Follow-up.","authors":"Makoto Watanabe, Tomoyuki Ogawa, Kanao Kobayashi, Narutaka Katsuya, Akira Ishikawa, Takao Hamamoto, Hiroaki Tahara, Tsutomu Ueda, Sachio Takeno","doi":"10.18926/AMO/68730","DOIUrl":"10.18926/AMO/68730","url":null,"abstract":"<p><p>Renal cell carcinoma (RCC) can metastasize hematogenously and recur after a long dormancy. Chromophobe RCC metastasized to the cervical lymph nodes 10 years after the primary resection in a woman who underwent nephrectomy for RCC (T1aN0M0 stage I). Metastatic RCC diagnosis was confirmed by aspiration. The lymph node mass was resected, and the tumor cells matched chromophobe RCC metastasis. No adjuvant therapy was administered due to the lack of evidence regarding adjuvant therapy for chromophobe RCC. Long-term surveillance is crucial in RCC because of the possibility of late metastasis. We reviewed the clinical aspects and literature on metastatic cervical RCC.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"79 3","pages":"213-219"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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