Acta medica Okayama最新文献

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A Mixed-Methods Study on Changes in Interprofessional Education Attitudes and Fundamental Competencies: A Pre-Post Analysis of Clinical Training in Dietetic Students. 跨专业教育态度和基本能力变化的混合方法研究:营养学学生临床培训前后分析。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70453
Mika Sonoi, Norihiro Sonoi, Yoko Koyama
{"title":"A Mixed-Methods Study on Changes in Interprofessional Education Attitudes and Fundamental Competencies: A Pre-Post Analysis of Clinical Training in Dietetic Students.","authors":"Mika Sonoi, Norihiro Sonoi, Yoko Koyama","doi":"10.18926/AMO/70453","DOIUrl":"10.18926/AMO/70453","url":null,"abstract":"<p><p>This study examined the effects of interprofessional education (IPE) on dietetics students during clinical training, focusing on changes in their attitudes toward IPE and their fundamental competencies. Eighty third-year female students (mean age, 21.0 years) at a Japanese women's university participated. Self-administered surveys were conducted before and after clinical training to assess attitudes toward IPE using the Readiness for Interprofessional Learning Scale (RIPLS) and the Shakaijin Kisoryoku (SKL; Fundamental Competencies for Working Persons) scale. Quantitative data were analyzed using paired t-tests, chi-squared tests, and cluster analyses. Qualitative data from open-ended responses were analyzed thematically. RIPLS and SKL scores increased significantly, from 65.3 to 68.9, and from 28. 4 to 33. 2, respectively (p<0.001). All 12 SKL items showed significant improvement. In free responses, \"initiative\" (66 mentions), \"communication\" (10), and \"execution\" (8) were the most frequently cited as improved competencies. Cluster analysis identified three groups: increasing scores (n=25), high baseline (n=30), and minimal change (n=25). No significant correlation was found between changes in RIPLS and SKL scores (r=-0.108, p=0.355). IPE integrated into clinical training may enhance dietetics students' attitudes toward interprofessional collaboration and contribute to the development of professional identity. Individualized, phased IPE implementation is recommended to accommodate differences in learner readiness.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"109-117"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complete Transection of the Common Bile Duct Caused by Blunt Abdominal Trauma: A Rare Case Report. 腹部钝性创伤致胆总管完全横断1例。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70457
Shinya Sakamoto, Motoyasu Tabuchi, Akira Hamada, Rika Yoshimatsu, Yuichi Saisaka, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi
{"title":"Complete Transection of the Common Bile Duct Caused by Blunt Abdominal Trauma: A Rare Case Report.","authors":"Shinya Sakamoto, Motoyasu Tabuchi, Akira Hamada, Rika Yoshimatsu, Yuichi Saisaka, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi","doi":"10.18926/AMO/70457","DOIUrl":"10.18926/AMO/70457","url":null,"abstract":"<p><p>Common bile duct (CBD) injury after blunt abdominal trauma is rare and difficult to diagnose. Delayed recognition leads to severe morbidity. A 70-year-old Japanese man was admitted after sustaining blunt abdominal trauma. Ultrasonography revealed intra-abdominal fluid, suggesting bleeding. Contrast-enhanced computed tomography revealed pancreatic head injury, intra-abdominal bleeding, and pseudoaneurysm of the anterior superior pancreatoduodenal artery (ASPDA). Bile duct injury was not evident. The application of transarterial embolization (TAE) controlled the bleeding. Canulation into the pancreatic or biliary duct was not possible during endoscopic retrograde cholangiopancreatography. An emergency laparotomy revealed severe pancreatic head and extrahepatic bile duct injuries. Pancreaticoduodenectomy/Child reconstruction was performed. Complete CBD transection was confirmed. The patient was ultimately discharged without complications. Early recognition, timely surgical management, and intensive care are essential for favorable outcomes in patients who have sustained abdominal trauma.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"147-152"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Necrotizing Fasciitis Caused by ESBL-Producing Raoultella ornithinolytica in an Immunocompromised Patient with VEXAS Syndrome. 免疫功能低下的VEXAS综合征患者中产生esbl的鸟嘌呤溶解拉乌尔氏菌引起的坏死性筋膜炎
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70456
Moe Sakamoto-Tokunaga, Takayuki Katsuyama, Masaki Matoba, Tomokazu Tamura, Natsuki Kubota, Yuya Terajima, Kenta Shidahara, Kei Hirose, Kazuya Matsumoto, Shoichi Nawachi, Takato Nakadoi, Yu Katayama, Keigo Hayashi, Yoshia Miyawaki, Eri Katsuyama, Haruki Watanabe, Mariko Takano-Narazaki, Yoshinori Matsumoto, Ken-Ei Sada, Shuma Tsuji, Kazuyoshi Gotoh, Shinnosuke Fukushima, Hideharu Hagiya, Jun Wada
{"title":"Necrotizing Fasciitis Caused by ESBL-Producing Raoultella ornithinolytica in an Immunocompromised Patient with VEXAS Syndrome.","authors":"Moe Sakamoto-Tokunaga, Takayuki Katsuyama, Masaki Matoba, Tomokazu Tamura, Natsuki Kubota, Yuya Terajima, Kenta Shidahara, Kei Hirose, Kazuya Matsumoto, Shoichi Nawachi, Takato Nakadoi, Yu Katayama, Keigo Hayashi, Yoshia Miyawaki, Eri Katsuyama, Haruki Watanabe, Mariko Takano-Narazaki, Yoshinori Matsumoto, Ken-Ei Sada, Shuma Tsuji, Kazuyoshi Gotoh, Shinnosuke Fukushima, Hideharu Hagiya, Jun Wada","doi":"10.18926/AMO/70456","DOIUrl":"10.18926/AMO/70456","url":null,"abstract":"<p><p>VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory somatic) syndrome has a poor prognosis, with infections being a major cause of death. Raoultella ornithinolytica is an environmental bacterium found predominantly in soil and water. Although R. ornithinolytica can cause various infections, necrotizing fasciitis due to this bacterium has not been reported. We describe the case of an 84-year-old Japanese male with VEXAS syndrome who developed septic shock and necrotizing fasciitis while he was under immunosuppressive therapy. The pathogen was initially misidentified as R. planticola by mass spectrometry but later confirmed by whole-genome sequencing as extended spectrum β-lactamase (ESBL) produced by R. ornithinolytica. Although a life-saving leg amputation was required, the patient recovered with appropriate antibiotic therapy. R. ornithinolytica is thus able to cause severe skin infections in immunocompromised individuals.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"141-145"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Proteinuria on Postoperative Complications Following Colorectal Cancer Surgery. 蛋白尿对大肠癌术后并发症的影响。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70455
Shunsuke Nakata, Fumiaki Takatsu, Yoshihiro Mikuriya, Tomokazu Kakishita, Shinji Hato, Koji Ohta, Takaya Kobatake
{"title":"Impact of Proteinuria on Postoperative Complications Following Colorectal Cancer Surgery.","authors":"Shunsuke Nakata, Fumiaki Takatsu, Yoshihiro Mikuriya, Tomokazu Kakishita, Shinji Hato, Koji Ohta, Takaya Kobatake","doi":"10.18926/AMO/70455","DOIUrl":"10.18926/AMO/70455","url":null,"abstract":"<p><p>Colorectal surgery is associated with a high incidence of postoperative complications regardless of the advances in surgical techniques and multidisciplinary treatment. Proteinuria is common in patients with malignancies, but few studies have investigated the association between preoperative proteinuria and patient prognoses, especially postoperative complications. We investigated the impact of proteinuria on patients undergoing colorectal surgery in a single-center, retrospective cohort study of 767 patients who underwent surgical resection for colorectal cancer between January 2016 and December 2022 at the National Hospital Organization Shikoku Cancer Center. Among them, 81 patients with preoperative proteinuria were compared with the control group of 686 patients without proteinuria. Our analyses revealed that the patients with proteinuria had malnutrition with a significantly lower prognostic nutritional index compared to the no-proteinuria control group (p<0.001). The proteinuria group had a significantly advanced tumor stage (p=0.005), experienced more bleeding during the surgery (p=0.002), and required more transfusions (p<0.001). Postoperative complications were significantly more frequent in the proteinuria group (p=0.03), thus demonstrating that proteinuria was independently associated with postoperative complications (p=0.045). Proteinuria in patients undergoing colorectal cancer surgery can therefore be considered a risk factor for postoperative complications.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"131-139"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Involvement of ADAM12 in TGF-β1-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts. ADAM12参与TGF-β1诱导的类风湿关节炎滑膜成纤维细胞增殖。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-04-01 DOI: 10.18926/AMO/70450
Deting Lin, Masahiro Horita, Masahito Watanabe, Joe Hasei, Takashi Ohtsuki, Noriaki Otsuka, Chinatsu Ichikawa, Noriyuki Shimizu, Shuichi Naniwa, Toshifumi Ozaki, Keiichiro Nishida
{"title":"Involvement of ADAM12 in TGF-β1-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts.","authors":"Deting Lin, Masahiro Horita, Masahito Watanabe, Joe Hasei, Takashi Ohtsuki, Noriaki Otsuka, Chinatsu Ichikawa, Noriyuki Shimizu, Shuichi Naniwa, Toshifumi Ozaki, Keiichiro Nishida","doi":"10.18926/AMO/70450","DOIUrl":"10.18926/AMO/70450","url":null,"abstract":"<p><p>A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 2","pages":"75-83"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Intraocular Tumor Likely from Hepatocellular Carcinoma Mimicking Panuveitis. 转移性眼内肿瘤可能来自肝细胞癌,类似全葡萄膜炎。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-02-01 DOI: 10.18926/AMO/70074
Eri Takasu, Yusuke Shiode, Hiroya Kindo, Shuhei Kimura, Mio Hosokawa, Ryo Matoba, Yuki Kanzaki, Tetsuro Morita, Takuya Adachi, Motoyuki Otsuka, Yuki Morizane
{"title":"Metastatic Intraocular Tumor Likely from Hepatocellular Carcinoma Mimicking Panuveitis.","authors":"Eri Takasu, Yusuke Shiode, Hiroya Kindo, Shuhei Kimura, Mio Hosokawa, Ryo Matoba, Yuki Kanzaki, Tetsuro Morita, Takuya Adachi, Motoyuki Otsuka, Yuki Morizane","doi":"10.18926/AMO/70074","DOIUrl":"10.18926/AMO/70074","url":null,"abstract":"<p><p>A 77-year-old man undergoing treatment for hepatocellular carcinoma (HCC) presented with blurred vision in his right eye, persisting for 2 months. Slit-lamp microscopy and fundus examination revealed inflammatory cells in the anterior chamber, severe vitreous opacities, and retinal vasculitis in the right eye. The patient underwent vitreous surgery with biopsy, and vitreous cytology confirmed a metastatic intraocular tumor originating from the HCC. Radiotherapy was administered to the right eye, with no recurrence of intraocular inflammation observed at 10 months post-irradiation.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 1","pages":"63-67"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Stroke Discharge Support Evaluation Scale for Ward Nurses in Acute Care Hospitals. 急性护理医院病区护士脑卒中出院支持评价量表的编制。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-02-01 DOI: 10.18926/AMO/70069
Hideki Yano, Yoko Takahata, Takeshi Yamaguchi, Shinya Saito
{"title":"Development of a Stroke Discharge Support Evaluation Scale for Ward Nurses in Acute Care Hospitals.","authors":"Hideki Yano, Yoko Takahata, Takeshi Yamaguchi, Shinya Saito","doi":"10.18926/AMO/70069","DOIUrl":"10.18926/AMO/70069","url":null,"abstract":"<p><p>This study aimed to develop a scale enabling nurses to objectively evaluate their own stroke discharge support, as a basis for enhancing its overall effectiveness. A draft scale was created based on a literature review, and consisted of a 51-item, 5-point Likert-type questionnaire administered to ward nurses engaged in stroke discharge support at acute care hospitals. Factor analysis was performed to refine the scale. Construct validity was assessed using the known-groups method, and reliability was evaluated through internal consistency analysis. The resulting Stroke Discharge Support Evaluation Scale comprises 29 items across 5 factors, each rated on a 5-point Likert scale. Analysis of the data collected from 237 valid responses demonstrated good internal consistency and supported the scale's construct validity. The Stroke Discharge Support Evaluation Scale is a reliable and valid tool enabling ward nurses in acute care hospitals to evaluate their own stroke discharge support.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 1","pages":"17-30"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective Treatment of Advanced Hepatocellular Carcinoma with Extensive Peritoneal Dissemination Using Lenvatinib. Lenvatinib有效治疗晚期肝细胞癌伴广泛腹膜播散。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-02-01 DOI: 10.18926/AMO/70075
Shinya Wakatsuki, Shinya Sakamoto, Akiko Ueno, Takaomi Namba, Yorito Yamamoto, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi
{"title":"Effective Treatment of Advanced Hepatocellular Carcinoma with Extensive Peritoneal Dissemination Using Lenvatinib.","authors":"Shinya Wakatsuki, Shinya Sakamoto, Akiko Ueno, Takaomi Namba, Yorito Yamamoto, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi","doi":"10.18926/AMO/70075","DOIUrl":"10.18926/AMO/70075","url":null,"abstract":"<p><p>Patients with hepatocellular carcinoma (HCC) and extensive peritoneal dissemination generally have a poor prognosis and are often resistant to systemic therapy. We report the case of a 47-year-old woman with HCC and massive peritoneal dissemination who presented with malignant ascites requiring repeated cell-free and concentrated ascites reinfusion therapy and peritoneovenous shunt placement, as well as malignant pleural effusion requiring pleurodesis. Combined immunotherapy with durvalumab/tremelimumab was initiated;however, disease progression was observed after three treatment courses, prompting a switch to lenvatinib therapy. Two months after initiation of lenvatinib, CT imaging demonstrated complete disappearance of arterial enhancement in the primary hepatic lesion, along with reduction in the size of peritoneal dissemination nodules. Thirteen months after switching to lenvatinib (16 months after the initial diagnosis), the alpha-fetoprotein level continued to decrease, and the disease remained stable under treatment. Despite the extremely high tumor burden, lenvatinib achieved disease stabilization and symptomatic improvement.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 1","pages":"69-74"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time Course of the Development and Loss of Delta-9-tetrahydrocannabinol Tolerance: Effects on Hypothermia and Spontaneous Locomotor Activity in Mice. δ -9-四氢大麻酚耐受性产生和丧失的时间过程:对小鼠低温和自发运动活动的影响。
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-02-01 DOI: 10.18926/AMO/70072
Yukiomi Eguchi, Soichiro Ushio, Keiichi Irie, Yuta Yamashita, Miyu Eguchi, Takafumi Nakano, Kenichi Mishima
{"title":"Time Course of the Development and Loss of Delta-9-tetrahydrocannabinol Tolerance: Effects on Hypothermia and Spontaneous Locomotor Activity in Mice.","authors":"Yukiomi Eguchi, Soichiro Ushio, Keiichi Irie, Yuta Yamashita, Miyu Eguchi, Takafumi Nakano, Kenichi Mishima","doi":"10.18926/AMO/70072","DOIUrl":"10.18926/AMO/70072","url":null,"abstract":"<p><p>Deregulation of cannabis use is gradually expanding in Europe and the United States. However, the biological processes driving tolerance to delta-9-tetrahydrocannabinol (Δ9-THC), the main psychoactive component of cannabis, remain unclear. Thus, this study aimed to investigate the mechanisms and time course of tolerance development and loss to Δ9-THC in mice. Male ICR mice (7 weeks old) were administered Δ9-THC once daily for 3 days and then divided into three groups according to the washout period (3-, 10-, and 17-day washout groups). After each washout, changes in body temperature and locomotor activity were measured following re-exposure to Δ9-THC. Furthermore, the mRNA expression levels of CB1 and CB2 receptors in the brain were evaluated using real-time PCR. On day 1, significant hypothermia and reduced spontaneous locomotor activity were observed in the Δ9-THC-treated mice compared with the vehicle-treated mice. Tolerance to the hypothermic and locomotor-suppressing effects of Δ9-THC developed on days 2 and 3, respectively, and dissipated after 3 and 11 days of washout, respectively. These differences in the rates of tolerance development and recovery may reflect distinct underlying mechanisms. No significant changes in receptor mRNA expression were observed. These findings highlight the complexity of Δ9-THC tolerance and its potential implications for long-term cannabis use.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 1","pages":"47-54"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Prescribing Patterns of Antiviral Drugs before and after Public Coverage Termination among Hospitalized COVID-19 Patients in Regional Hospitals in Japan: A Retrospective, Multicenter Study. 日本地区医院COVID-19住院患者公共覆盖终止前后抗病毒药物处方模式的变化:一项回顾性、多中心研究
IF 0.8 4区 医学
Acta medica Okayama Pub Date : 2026-02-01 DOI: 10.18926/AMO/70073
Hidemasa Akazawa, Hideharu Hagiya, Shinnosuke Fukushima, Shohei Yamamoto, Yasuhiro Nakano, Fumio Otsuka
{"title":"Changes in Prescribing Patterns of Antiviral Drugs before and after Public Coverage Termination among Hospitalized COVID-19 Patients in Regional Hospitals in Japan: A Retrospective, Multicenter Study.","authors":"Hidemasa Akazawa, Hideharu Hagiya, Shinnosuke Fukushima, Shohei Yamamoto, Yasuhiro Nakano, Fumio Otsuka","doi":"10.18926/AMO/70073","DOIUrl":"10.18926/AMO/70073","url":null,"abstract":"<p><p>In Japan, antiviral agents for COVID-19 were freely available until September 2023 as part of national policy. This study evaluated changes in these agents' prescribing patterns and the patient outcomes following the policy shift. We conducted a multicenter retrospective study at four hospitals in Japan's Okayama and Kagawa prefectures from January 2022 to March 2024. The study period was divided into the public-expenditure phase (January 2022 to September 2023) and the post-expenditure phase (October 2023 to March 2024). We extracted the hospitalized patients' clinical data from the electronic database. The study's primary outcome was the antiviral prescription rate; the secondary outcome was in-hospital mortality. Among the 302 hospitalized patients (median age 85 years), 52.0% were classified as having a mild condition. Of the patients with mild conditions, 37.7% were diagnosed in outpatient settings prior to hospitalization. During the public-expenditure phase, 47.4% of the patients received antivirals as outpatients, mainly molnupiravir (80.9%). In the post-expenditure period, 80.0% of the patients were prescribed antivirals, mostly molnupiravir (91.7%). The antiviral prescription rate was significantly higher after the policy change. The overall in-hospital mortality was 15.8%, with no significant difference between the two periods (17.0% vs. 10.5%). Despite the termination of government funding, antiviral prescriptions remained frequent at community hospitals located in highly aging regions of western Japan such as Okayama and Kagawa prefectures. Mortality remains high among the elderly, highlighting the need for continued antiviral therapy and booster vaccinations.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"80 1","pages":"55-62"},"PeriodicalIF":0.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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