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Phenotypic and Genetic Characteristics of Carbapenemase-Producing Enterobacterales Isolates at Okayama University Hospital. 冈山大学医院产碳青霉烯酶肠杆菌属分离菌的表型和遗传特征。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67657
Kazuyoshi Gotoh, Makoto Miyoshi, I Putu Bayu Mayura, Shuma Tsuji, Koji Iio, Shinnosuke Fukushima, Osamu Matsushita, Hideharu Hagiya
{"title":"Phenotypic and Genetic Characteristics of Carbapenemase-Producing Enterobacterales Isolates at Okayama University Hospital.","authors":"Kazuyoshi Gotoh, Makoto Miyoshi, I Putu Bayu Mayura, Shuma Tsuji, Koji Iio, Shinnosuke Fukushima, Osamu Matsushita, Hideharu Hagiya","doi":"10.18926/AMO/67657","DOIUrl":"10.18926/AMO/67657","url":null,"abstract":"<p><p>Spread of carbapenemase-producing Enterobacterales (CPE) is an ongoing public health issue worldwide, including in Japan. In this study, we investigated the phenotypic and genetic characteristics of CPE isolates at Okayama University Hospital over the 5 years (2013-2018) prior to the outbreak of the 2019 coronavirus pandemic. Of 24 carbapenem-resistant Enterobacterales isolated during the study period, we identified 8 CPE isolates harboring blaIMP-1 (5 isolates) and blaIMP-6 genes (3 isolates). Bacterial species and carbapenem susceptibility patterns exhibited diversity. Minimum inhibitory concentrations (MICs) of meropenem were generally higher than those of imipenem and biapenem. Results of pulsed-field gel electrophoresis demonstrated that neither clonal nor plasmid-mediated outbreaks of blaIMP-harboring CPE isolates have developed at our hospital. One Klebsiella oxytoca isolate showed a high MIC (128 μg/mL) of meropenem, which could be explained by the high plasmid copy number. Subsequent analysis of this isolate may elucidate the intricacies of carbapenem resistance profiles among CPE isolates. Collectively, our findings underscore the necessity for ongoing genetic surveillance of CPE, complemented by tailored approaches for infection prevention and control.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"371-376"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focal Cerebral Hypoperfusion Detected by Arterial Spin-Labeled Magnetic Resonance Imaging in Patients with Migraine Presenting with Neurological Symptoms Concomitant with or without Headache. 通过动脉自旋标记磁共振成像检测伴有或不伴有头痛的偏头痛患者的神经症状的局部脑灌注不足。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67666
Kenichi Kashihara, Minoru Irisawa, Wataru Takao
{"title":"Focal Cerebral Hypoperfusion Detected by Arterial Spin-Labeled Magnetic Resonance Imaging in Patients with Migraine Presenting with Neurological Symptoms Concomitant with or without Headache.","authors":"Kenichi Kashihara, Minoru Irisawa, Wataru Takao","doi":"10.18926/AMO/67666","DOIUrl":"https://doi.org/10.18926/AMO/67666","url":null,"abstract":"<p><p>We investigated patients with migraine or migraine variants who exhibited focal cerebral hypoperfusion on arterial spin-labeled (ASL) magnetic resonance (MR) imaging along with neurological symptoms. Fourteen patients with migraine demonstrated focal cerebral hypoperfusion. Three other patients did not have a history of recurrent headaches but exhibited comparable cerebral hypoperfusion to migraine patients on ASL-MRI in addition to neurological symptoms. Patients with migraine may present with neurological symptoms associated with cortical spreading depression during, after, or even without a headache phase. Additionally, the isolated neurological symptoms may be caused by a pathophysiology identical to that of migraine but without presenting with recurrent headaches.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"413-421"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Severe Febrile Thrombocytopenia Syndrome: A Case Report and Literature Review. 小儿严重发热性血小板减少综合征：病例报告和文献综述。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67664
Yusuke Toyota, Kazuhiro Uda, Komei Shirabe, Tadashi Moriwake
{"title":"Pediatric Severe Febrile Thrombocytopenia Syndrome: A Case Report and Literature Review.","authors":"Yusuke Toyota, Kazuhiro Uda, Komei Shirabe, Tadashi Moriwake","doi":"10.18926/AMO/67664","DOIUrl":"https://doi.org/10.18926/AMO/67664","url":null,"abstract":"<p><p>Severe febrile thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease that is endemic in parts of eastern Asia. Few pediatric cases have been reported. We describe a case of SFTS in a seven-year-old girl who presented with prolonged fever and gastrointestinal symptoms. Leukopenia and thrombocytopenia on hematology, and a history of outdoor activity led us to diagnose SFTS, although the patient had no tick bite marks. We also review the literature and discuss the characteristics of pediatric SFTS. Physicians should consider SFTS in the differential diagnosis of fever with thrombocytopenia in children living in endemic areas.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"401-405"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Affecting Dynamic Postural Control Ability in Adolescent Idiopathic Scoliosis. 影响青少年特发性脊柱侧凸动态姿势控制能力的因素。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67655
Ryoko Yamawaki, Yoshiaki Oda, Shuhei Yamane, Koji Uotani, Haruo Misawa, Yoshimi Katayama, Masanori Hamada, Toshifumi Ozaki
{"title":"Factors Affecting Dynamic Postural Control Ability in Adolescent Idiopathic Scoliosis.","authors":"Ryoko Yamawaki, Yoshiaki Oda, Shuhei Yamane, Koji Uotani, Haruo Misawa, Yoshimi Katayama, Masanori Hamada, Toshifumi Ozaki","doi":"10.18926/AMO/67655","DOIUrl":"https://doi.org/10.18926/AMO/67655","url":null,"abstract":"<p><p>Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"357-362"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small-for-Gestational-Age Status and the Risk of Kawasaki Disease: A Nationwide Birth Cohort in Japan. 小于胎龄状态与川崎病风险：日本全国出生队列。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-10-01 DOI: 10.18926/AMO/67656
Satoe Takanaga, Naomi Matsumoto, Tomoka Kadowaki, Soshi Takao, Takashi Yorifuji
{"title":"Small-for-Gestational-Age Status and the Risk of Kawasaki Disease: A Nationwide Birth Cohort in Japan.","authors":"Satoe Takanaga, Naomi Matsumoto, Tomoka Kadowaki, Soshi Takao, Takashi Yorifuji","doi":"10.18926/AMO/67656","DOIUrl":"https://doi.org/10.18926/AMO/67656","url":null,"abstract":"<p><p>Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a nationwide Japanese birth cohort study conducted in 2010 (n=34,579), we investigated whether SGA increases the risk of KD. SGA was defined as birth weight below the 10th percentile for gestational age. The outcome was hospitalization for KD between 6 and 30 months of age. The association between SGA and hospitalization for KD, adjusted for child and maternal factors, was examined using logistic regression. Of the 231 children hospitalized for KD, 9.5% were SGA. Further statistical analysis showed that SGA did not increase the odds ratio (OR) of hospitalization for KD (adjusted OR 1.12, 95% confidence interval 0.71-1.75). This result was not changed with stratification by early daycare attendance and preterm status. Reasons for the lack of association may include the multifactorial pathogenesis of KD; in addition, the types of infections to which SGA infants are predisposed may differ from those triggering KD. Overall, our large nationwide study found no association between SGA and KD.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 5","pages":"363-370"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can Pelvic Lymph Node Dissection in Prostate Cancer Patients with a 5% Briganti Nomogram Cut-off Value Provide an Oncological Benefit? A Large Multi-Institutional Cohort Study in Japan. 5% Briganti Nomogram 临界值的前列腺癌患者盆腔淋巴结清扫能带来肿瘤学获益吗？日本一项大型多机构队列研究。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-08-01 DOI: 10.18926/AMO/67546
Naoya Sugihara, Katsuyoshi Hashine, Natsumi Yamashita, Miki Sakamoto, Masato Terashita, Keisuke Funaki, Kaori Saiki, Takatora Sawada, Toshio Kakuda, Kenichi Nishimura, Tetsuya Fukumoto, Noriyosi Miura, Yuki Miyauchi, Tadahiko Kikugawa, Takashi Saika
{"title":"Can Pelvic Lymph Node Dissection in Prostate Cancer Patients with a 5% Briganti Nomogram Cut-off Value Provide an Oncological Benefit? A Large Multi-Institutional Cohort Study in Japan.","authors":"Naoya Sugihara, Katsuyoshi Hashine, Natsumi Yamashita, Miki Sakamoto, Masato Terashita, Keisuke Funaki, Kaori Saiki, Takatora Sawada, Toshio Kakuda, Kenichi Nishimura, Tetsuya Fukumoto, Noriyosi Miura, Yuki Miyauchi, Tadahiko Kikugawa, Takashi Saika","doi":"10.18926/AMO/67546","DOIUrl":"https://doi.org/10.18926/AMO/67546","url":null,"abstract":"<p><p>The Briganti nomogram (cut-off value 5%) is commonly used to determine the indications for pelvic lymph node dissection (PLND) in patients with prostate cancer. We retrospectively analyzed the potential oncological benefit of PLND based on the 5% cut-off value on the Briganti nomogram. We obtained the data from the Medical Investigation Cancer Network (MICAN) Study, which included 3,463 patients who underwent a radical prostatectomy (RP) at nine institutions in Japan between 2010 and 2020. We included patients with Briganti scores ≥ 5% and a follow-up period ≥6 months and excluded patients categorized in the very high-risk group (based on NCCN categories); a final total of the cases of 1,068 patients were analyzed. The biochemical recurrence (BCR)-free survival was significantly worse in the patients who underwent PLND compared to those who did not (p=0.019). A multivariate analysis showed that high prostate-specific antigen (PSA) levels (p<0.001) and an advanced T-stage (p=0.018) were significant prognostic factors for BCR, whereas PLND had no effect on BCR (p=0.059). Thus, PLND in patients with prostate cancer whose Briganti score was 5% did not provide any oncological benefit. Further research is necessary to determine the indication criteria for conducting PLND.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 4","pages":"307-312"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Subglottic Pleomorphic Adenoma: Magnetic Resonance Findings. 罕见的声门下多形性腺瘤：磁共振检查结果
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-08-01 DOI: 10.18926/AMO/67549
Chieko Furukawa, Tomoyasu Tachibana, Tetsuji Nobuhisa, Yuichiro Kanie, Yoji Wani, Jun-Ya Matsumoto, Akifumi Kariya, Asuka Sato, Iichiro Ishikawa, Yuto Naoi, Mizuo Ando
{"title":"A Rare Subglottic Pleomorphic Adenoma: Magnetic Resonance Findings.","authors":"Chieko Furukawa, Tomoyasu Tachibana, Tetsuji Nobuhisa, Yuichiro Kanie, Yoji Wani, Jun-Ya Matsumoto, Akifumi Kariya, Asuka Sato, Iichiro Ishikawa, Yuto Naoi, Mizuo Ando","doi":"10.18926/AMO/67549","DOIUrl":"https://doi.org/10.18926/AMO/67549","url":null,"abstract":"<p><p>No previous study has published magnetic resonance imaging (MRI) findings for a subglottic pleomorphic adenoma. Here, we describe the case of a 62-year-old man with a subglottic pleomorphic adenoma. Endoscopic findings revealed a smooth-surfaced tumor arising from the subglottic posterior wall. MRI revealed the lesion as an isointense region on T1-weighted images, which was homogeneously enhanced. This lesion showed a heterogeneously hyperintense region on T2-weighted images. Diffusion-weighted imaging (DWI) showed slightly high intensity in the same area, with a normal or only slightly high apparent diffusion coefficient (ADC). Laryngomicrosurgery was performed for transoral excision of the subglottic tumor, resulting in a postsurgical diagnosis of pleomorphic adenoma.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 4","pages":"331-335"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pneumocephalus with Inverted Papilloma in the Frontoethmoidal Sinus: Case Report and Literature Review. 前牙状窦倒置乳头状瘤引发的气胸：病例报告和文献综述。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-08-01 DOI: 10.18926/AMO/67550
Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Sawako Ono, Aiko Shimizu, Ryosuke Ikemachi, Yosuke Okazaki, Tomoyuki Ota, Hiroshi Matsumoto, Shotaro Miyamoto, Munechika Tsumura, Seiya Hayashi, Michiari Umakoshi, Koji Hirashita, Mizuo Ando
{"title":"Pneumocephalus with Inverted Papilloma in the Frontoethmoidal Sinus: Case Report and Literature Review.","authors":"Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Sawako Ono, Aiko Shimizu, Ryosuke Ikemachi, Yosuke Okazaki, Tomoyuki Ota, Hiroshi Matsumoto, Shotaro Miyamoto, Munechika Tsumura, Seiya Hayashi, Michiari Umakoshi, Koji Hirashita, Mizuo Ando","doi":"10.18926/AMO/67550","DOIUrl":"https://doi.org/10.18926/AMO/67550","url":null,"abstract":"<p><p>Here, we describe the unique case of a pneumocephalus originating from an inverted papilloma (IP) in the frontoethmoidal sinus. A 71-year-old man with diabetes presented with headaches and altered consciousness. Imaging revealed the pneumocephalus together with bone destruction in the left frontal sinus. He underwent simultaneous endoscopic endonasal and transcranial surgery using an ORBEYE exoscope. Pathological diagnosis of the tumor confirmed IP. Post-surgery, the pneumocephalus was significantly resolved and the squamous cell carcinoma antigen level, which had been elevated, decreased. This case underscores the importance of a multidisciplinary approach and innovative surgical methods in treating complex sinonasal pathologies.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 4","pages":"337-343"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Treatment of an Abdominal Aortic Aneurysm in a Patient with a Liver Abscess. 肝脓肿患者腹主动脉瘤的手术治疗。
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-08-01 DOI: 10.18926/AMO/67553
Gentaro Kato, Yuto Narumiya, Michihiro Okuyama, Shuji Shimizu, Kenji Sangawa, Shu Yamamoto
{"title":"Surgical Treatment of an Abdominal Aortic Aneurysm in a Patient with a Liver Abscess.","authors":"Gentaro Kato, Yuto Narumiya, Michihiro Okuyama, Shuji Shimizu, Kenji Sangawa, Shu Yamamoto","doi":"10.18926/AMO/67553","DOIUrl":"https://doi.org/10.18926/AMO/67553","url":null,"abstract":"<p><p>The presence of an intraperitoneal source of infection, e.g., a liver abscess, can be an obstacle to performing an abdominal aortic surgery with a midline laparotomy because graft infection is one of the most critical complications of aortic surgery. We report the successful Y-grafting of a pararenal abdominal aortic aneurysm through a retroperitoneal approach in a 67-year-old male undergoing liver abscess drainage. The retroperitoneal approach to the abdominal aorta may be useful for abdominal aortic surgery in patients with a localized intraperitoneal infection.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 4","pages":"345-347"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Middle-Ear Salivary Gland Choristoma with Congenital, Single-Sided Hearing Loss. 中耳唾液腺瘤伴先天性单侧听力损失
IF 0.6 4区 医学
Acta medica Okayama Pub Date : 2024-08-01 DOI: 10.18926/AMO/67554
Yuichiro Tominaga, Akiko Sugaya, Shin Kariya, Aiko Shimizu, Yuko Kataoka, Mizuo Ando
{"title":"Middle-Ear Salivary Gland Choristoma with Congenital, Single-Sided Hearing Loss.","authors":"Yuichiro Tominaga, Akiko Sugaya, Shin Kariya, Aiko Shimizu, Yuko Kataoka, Mizuo Ando","doi":"10.18926/AMO/67554","DOIUrl":"https://doi.org/10.18926/AMO/67554","url":null,"abstract":"<p><p>Middle-ear salivary gland choristoma (SGCh) is a rare, benign tumor that causes conductive hearing loss owing to middle-ear morphological abnormalities. Early diagnosis is challenging, and surgical resection is indispensable for a definitive diagnosis. We report the case of a 3-year-old boy diagnosed with middle-ear SGCh during the follow-up period for left-sided hearing loss discovered at newborn hearing screening (NHS). Long-term follow-up after the NHS result, subsequent computed tomography/magnetic resonance imaging, and surgical resection led to its relatively early diagnosis and treatment.</p>","PeriodicalId":7017,"journal":{"name":"Acta medica Okayama","volume":"78 4","pages":"349-355"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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