Acta Haematologica最新文献

Consensus Statements Highlight the Need of Harmonizing Chronic Lymphocytic Leukemia Management Worldwide. 共识声明强调全球统一慢性淋巴细胞白血病管理的必要性。

IF 1.7 4区医学

Acta Haematologica Pub Date : 2024-01-01 Epub Date: 2023-08-07 DOI: 10.1159/000533349

Stefano Molica, Marco Rossi, David Allsup

引用次数: 0

Immunotherapy for Acute Myeloid Leukemia: Current Trends, Challenges, and Strategies. 急性髓性白血病的免疫疗法：当前趋势、挑战和策略》。

IF 1.7 4区医学

Acta Haematologica Pub Date : 2024-01-01 Epub Date: 2023-09-06 DOI: 10.1159/000533990

Evan C Chen, Jacqueline S Garcia

引用次数: 0

Immune Dysfunction and Infection - Interaction between CLL and Treatment: A Reflection on Current Treatment Paradigms and Unmet Needs. 免疫功能失调与感染--CLL 与治疗之间的相互作用：对当前治疗范例和未满足需求的反思。

IF 1.7 4区医学

Acta Haematologica Pub Date : 2024-01-01 Epub Date: 2023-07-27 DOI: 10.1159/000533234

Ernesto Gargiulo, Rebecca Svanberg Teglgaard, Tereza Faitová, Carsten Utoft Niemann

{"title":"Immune Dysfunction and Infection - Interaction between CLL and Treatment: A Reflection on Current Treatment Paradigms and Unmet Needs.","authors":"Ernesto Gargiulo, Rebecca Svanberg Teglgaard, Tereza Faitová, Carsten Utoft Niemann","doi":"10.1159/000533234","DOIUrl":"10.1159/000533234","url":null,"abstract":"Background: Chronic lymphocytic leukemia (CLL) is a hematological malignancy characterized by immune dysfunction, which significantly contributes to increased morbidity and mortality due to infections.Summary: Advancement in therapeutic strategies based on combination chemoimmunotherapy and targeted treatment have increased life expectancy for patients affected by CLL. However, mortality and morbidity due to infection showed no improvement over the last decades. Although therapy options are highly efficient in targeting leukemic cells, several studies highlighted the interactions of different treatments with the tumor microenvironment immune components, significantly impacting their clinical efficacy and fostering increased risk of infections.Key messages: Given the profound immune dysfunction caused by CLL itself, treatment can thus represent a double-edged sword. Thus, it is essential to increase our understanding and awareness on how conventional therapies affect the disease-microenvironment-infection axis to ensure the best personalized strategy for each patient. This requires careful consideration of the advantages and disadvantages of efficient treatments, whether chemoimmunotherapy or targeted combinations, leading to risk of infectious complications. To this regard, our machine learning-based algorithm CLL Treatment-Infection Model, currently implemented into the local electronic health record system for Eastern Denmark, aims at early identification of patients at high risk of serious infections (PreVent-ACaLL; NCT03868722). We here review strategies for management of immune dysfunction and infections in CLL.","PeriodicalId":6981,"journal":{"name":"Acta Haematologica","volume":" ","pages":"84-98"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9876819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Challenging Management of Acute Thrombotic Microangiopathy in Pregnancy. 妊娠期急性血栓性微血管病的挑战性管理。

IF 2.4 4区医学

Acta Haematologica Pub Date : 2023-01-01 DOI: 10.1159/000527553

Bárbara Marques, Catarina Nora, Daniela Coelho, Patrícia Martinho, Teresa Fidalgo, Marília Gomes, Letícia Ribeiro, Catarina Geraldes, José Pedro Carda

引用次数: 0

Prognostic Significance of CD20 Expression in Children with Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia. CD20在费城染色体阴性B细胞前体急性淋巴细胞白血病患儿中表达的预后意义。

IF 2.4 4区医学

Acta Haematologica Pub Date : 2023-01-01 Epub Date: 2023-05-07 DOI: 10.1159/000530849

Yu Wang, Yu-Juan Xue, Yue-Ping Jia, Ying-Xi Zuo, Ai-Dong Lu, Le-Ping Zhang

{"title":"Prognostic Significance of CD20 Expression in Children with Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia.","authors":"Yu Wang, Yu-Juan Xue, Yue-Ping Jia, Ying-Xi Zuo, Ai-Dong Lu, Le-Ping Zhang","doi":"10.1159/000530849","DOIUrl":"10.1159/000530849","url":null,"abstract":"Introduction: The prognostic significance of CD20 in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) remains unclear. Therefore, in this study, we evaluated the prognostic value of CD20 expression in leukemia blasts in pediatric BCP-ALL at our institute.Methods: Between 2005 and 2017, 796 children with newly diagnosed Philadelphia-negative BCP-ALL were enrolled consecutively; clinical characteristics and treatment outcomes were analyzed and compared between CD20-positive and CD20-negative groups.Results: CD20 positivity was observed in 22.7% of enrolled patients. The analysis of overall and event-free survival showed that white blood cell count ≥50 × 109/L, no ETV6-RUNX1, day 33 minimal residual disease (MRD) ≥0.1%, and week 12 MRD ≥0.01% were independent risk factors. Meanwhile, in the CD20-positive group, week 12 MRD ≥0.01% was the only factor associated with long-term survival. Moreover, subgroup analysis revealed that in patients with extramedullary involvement (p = 0.047), MRD ≥0.1% on day 33 (p = 0.032), or MRD ≥0.01% at week 12 (p = 0.004), CD20 expression led to a poorer outcome compared to those without CD20 expression.Conclusions: Pediatric BCP-ALL with CD20 expression had unique clinicopathological characteristics, and MRD remained the major prognostic factor. CD20 expression had no prognostic value in pediatric BCP-ALL.","PeriodicalId":6981,"journal":{"name":"Acta Haematologica","volume":" ","pages":"349-357"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9754731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Splenectomy Outcomes in Relapsed or Refractory Immune Thrombocytopenia. 复发或难治性免疫性血小板减少症患者脾切除术预后的预测。

IF 2.4 4区医学

Acta Haematologica Pub Date : 2023-01-01 DOI: 10.1159/000530678

Philip Murphy

引用次数: 0

The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia. 滤泡调节性T细胞/滤泡辅助性T细胞在原发性免疫性血小板减少症中的作用

IF 2.4 4区医学

Acta Haematologica Pub Date : 2023-01-01 DOI: 10.1159/000529963

Mingling Sun, Xiujuan Wang, Lei Wang, Xinyou Wang, Wenxia Fan, Ying Liu, Qinzhi Li, Ning Zhang, Xinhong Guo

{"title":"The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia.","authors":"Mingling Sun, Xiujuan Wang, Lei Wang, Xinyou Wang, Wenxia Fan, Ying Liu, Qinzhi Li, Ning Zhang, Xinhong Guo","doi":"10.1159/000529963","DOIUrl":"https://doi.org/10.1159/000529963","url":null,"abstract":"Introduction: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic targets in ITP.Methods: The differentially expressed genes (DEGs) between ITP patients and controls in GSE43177 and PRJNA299534 were analyzed. The intersections of the two DEG groups were screened as common genes, and enrichment analysis was performed. Additionally, differential analysis of immune cell levels between ITP and controls was performed. Changes in the proportions of T follicular helper (Tfh) and follicular regulatory T (Tfr) cells in peripheral blood samples from ITP patients, ITP patients responding to therapy, and healthy controls were identified. The expression changes in B-cell lymphoma (Bcl)-6 and interleukin (IL)-21 were further evaluated.Results: A total of 76 common genes were identified, and enrichment analysis found that these genes were mainly associated with neutrophil-mediated immunity, the MAPK signaling pathway, and the FOXO signaling pathway. Furthermore, we found different levels of Tfh cells in patients with ITP and controls. The level of Tfh cells in the peripheral blood is significantly increased in ITP patients and declines after responding to therapy. The Tfr/Tfh ratio was reduced in ITP patients and increased after responding to therapy. IL-21 and Bcl-6 were more highly expressed in ITP patients than in controls.Conclusion: We identified abnormally expressed genes in ITP related to immune-related biological functions. We further identified the changes in Tfh and Tfr cells during ITP treatment. This provides a rationale for immunotherapy in ITP patients.","PeriodicalId":6981,"journal":{"name":"Acta Haematologica","volume":"146 4","pages":"267-276"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waldenström Macroglobulinemia and Non-IgM-Type Lymphoplasmacytic Lymphoma Are Genetically Similar. Waldenström巨球蛋白血症和非IgM型淋巴母细胞淋巴瘤在基因上相似。

IF 2.4 4区医学

Acta Haematologica Pub Date : 2023-01-01 Epub Date: 2023-03-14 DOI: 10.1159/000530100

Maaya Awata-Shiraiwa, Akihiko Yokohama, Yukihiro Kanai, Nanami Gotoh, Tetsuhiro Kasamatsu, Hiroshi Handa, Takayuki Saitoh, Hirokazu Murakami, Junko Hirato, Hayato Ikota, Norifumi Tsukamoto

{"title":"Waldenström Macroglobulinemia and Non-IgM-Type Lymphoplasmacytic Lymphoma Are Genetically Similar.","authors":"Maaya Awata-Shiraiwa, Akihiko Yokohama, Yukihiro Kanai, Nanami Gotoh, Tetsuhiro Kasamatsu, Hiroshi Handa, Takayuki Saitoh, Hirokazu Murakami, Junko Hirato, Hayato Ikota, Norifumi Tsukamoto","doi":"10.1159/000530100","DOIUrl":"10.1159/000530100","url":null,"abstract":"Introduction: Waldenström macroglobulinemia (WM) represents a subset of lymphoplasmacytic lymphoma (LPL) with the immunoglobulin (Ig)M paraprotein. MYD88 L265P and CXCR4 mutations are common mutations in WM patients, and mutations in ARID1A and KMT2D (MLL2) have also been reported. However, little information has been accumulated on genetic changes in LPL with other paraproteins like IgG.Methods: We therefore aimed to evaluate genetic differences between WM and LPL with non-IgM paraprotein (non-IgM-type LPL) using targeted next-generation sequencing (NGS) in 20 Japanese patients (10 with WM, 10 with non-IgM-type LPL).Results: Mutations were detected in ARID1A (10%), CXCR4 (20%), MYD88 (90%), and KMT2D (0%) for WM patients and in ARID1A (10%), CXCR4 (20%), MYD88 (70%), and KMT2D (10%) for non-IgM-type LPL patients. No significant differences were identified. No mutations were detected in NOTCH2, PRDM1, CD274 (PD-L1), PDCD1LG2 (PD-L2), RAG2, MYBBP1A, TP53, or CD79B.Discussion: Mutant allele frequency in MYD88 L265P did not differ significantly between WM and non-IgM-type LPL. Most mutations detected by NGS were subclonal following MYD88 L265P, although one non-IgM-type LPL patient harbored only CXCR4 S338X mutation. Our NGS analyses reveal genetic characteristics in LPL patients and suggest genetic similarities between these two subsets of LPL, WM and non-IgM-type.","PeriodicalId":6981,"journal":{"name":"Acta Haematologica","volume":" ","pages":"384-390"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9465826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Myeloid Leukemia with NPM1 Mutation and Disseminated Leukemia Cutis: Achievement of Molecular Complete Remission by Venetoclax/Azacitidine Combination in a Very Old Patient. NPM1突变的急性髓细胞白血病和播散性白血病：Venetoclax/阿扎胞苷联合治疗高龄患者实现分子完全缓解。

IF 2.4 4区医学

Acta Haematologica Pub Date : 2023-01-01 Epub Date: 2023-05-17 DOI: 10.1159/000531101

Pasquale Niscola, Carla Mazzone, Stefano Fratoni, Nicolina Rita Ardu, Laura Cesini, Marco Giovannini, Tiziana Ottone, Lucia Anemona, Maria Teresa Voso, Paolo de Fabritiis

引用次数: 1

A Longitudinal Assessment of the Natural Change in Haemoglobin, Haematocrit, and Mean Corpuscular Volume with Age. 血红蛋白、红细胞压积和平均红细胞体积随年龄自然变化的纵向评估。

IF 2.4 4区医学

Acta Haematologica Pub Date : 2023-01-01 DOI: 10.1159/000529356

Idan Goldberg, Eytan Cohen, Anat Gafter-Gvili, Tzippy Shochat, Eitan Kugler, Ili Margalit, Elad Goldberg, Pia Raanani, Ilan Krause

{"title":"A Longitudinal Assessment of the Natural Change in Haemoglobin, Haematocrit, and Mean Corpuscular Volume with Age.","authors":"Idan Goldberg, Eytan Cohen, Anat Gafter-Gvili, Tzippy Shochat, Eitan Kugler, Ili Margalit, Elad Goldberg, Pia Raanani, Ilan Krause","doi":"10.1159/000529356","DOIUrl":"https://doi.org/10.1159/000529356","url":null,"abstract":"Introduction: We aimed to assess the natural annual trends in the levels of haemoglobin, haematocrit, and mean corpuscular volume (MCV) in a population of adults, together with the influence of different clinical parameters on these trends.Methods: A retrospective analysis was carried out on data from a large cohort of subjects attending a screening centre in Israel. For each subject, the yearly average change of haemoglobin, haematocrit, and MCV was calculated. Statistical analysis was performed for the whole cohort and for different subgroups.Results: The study included 3,551 subjects. The average annual rates of decline were found to be -0.0550 g/dL (95% confidence interval [CI] -0.0590 g/dL to -0.0503 g/dL) and -0.097% (95% CI -0.112% to -0.083%) for haemoglobin and haematocrit, respectively. An average annual increase in the MCV level by 0.184 fL (95% CI 0.168 fL-0.200 fL) was found. Among men, the rate of decline in haemoglobin was found to be twice as high compared with women -0.06 g/dL versus -0.03 g/dL, respectively (p = 0.0063). In a multivariate analysis, gender remained the only parameter significantly associated with the annual decline of haemoglobin (p = 0.0001).Conclusion: An annual average decrease in the levels of haemoglobin and haematocrit together with an annual increase in MCV was found. These changes were more prominent in men.","PeriodicalId":6981,"journal":{"name":"Acta Haematologica","volume":"146 3","pages":"206-213"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9568688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1