Autism Research最新文献

Parental age at birth, telomere length, and autism spectrum disorders in the UK Biobank cohort 英国生物库队列中父母的出生年龄、端粒长度和自闭症谱系障碍。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-30 DOI: 10.1002/aur.3258

Qiaofeng Ye, Abner T. Apsley, Waylon J. Hastings, Laura Etzel, Craig Newschaffer, Idan Shalev

{"title":"Parental age at birth, telomere length, and autism spectrum disorders in the UK Biobank cohort","authors":"Qiaofeng Ye, Abner T. Apsley, Waylon J. Hastings, Laura Etzel, Craig Newschaffer, Idan Shalev","doi":"10.1002/aur.3258","DOIUrl":"10.1002/aur.3258","url":null,"abstract":"Older parental age at birth is associated with increased risk of autism spectrum disorders (ASD) in offspring. Independently, shorter telomere length (TL) has also been shown to be associated with ASD in children. However, older paternal age at birth, with or without controlling for maternal age, has been associated with longer TL, a seemingly contradictory finding. Here, we conducted a retrospective cohort study among participants in the UK Biobank to disentangle associations between leukocyte TL and ASD status in adults, and the potential moderation by parental age on adult offspring's TL. Participants with ASD diagnosis (N = 87) with a mean age of 46.0 (SD 4.4) years were matched to participants without ASD diagnosis (N = 870) based on age, sex, ethnicity, education, household income, and assessment center. No statistically significant differences were seen in TL between participants with and without ASD when parental age at birth was not considered. However, there was a significant interaction between ASD diagnostic status and parental age on participants' TL, such that older paternal or maternal age at birth was more strongly associated with longer TL in participants with ASD. This study suggests that the shortened TL observed in children with ASD in previous research may partially depend on parental age at birth. Future studies tracking TL attrition before ASD diagnosis are warranted to depict temporal associations and the interacting effects of parental age at birth and ASD status on TL across the lifespan.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2223-2231"},"PeriodicalIF":5.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional differences in autism and intellectual disability risk associated with cesarean section delivery 与剖腹产有关的自闭症和智障风险的地区差异。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-17 DOI: 10.1002/aur.3247

Deborah A. Bilder, Scott Sullivan, Michelle M. Hughes, Susan Dalton, Jennifer Hall-Lande, Connor Nicholls, Amanda V. Bakian

{"title":"Regional differences in autism and intellectual disability risk associated with cesarean section delivery","authors":"Deborah A. Bilder, Scott Sullivan, Michelle M. Hughes, Susan Dalton, Jennifer Hall-Lande, Connor Nicholls, Amanda V. Bakian","doi":"10.1002/aur.3247","DOIUrl":"10.1002/aur.3247","url":null,"abstract":"Prior epidemiological studies investigating the association between delivery mode (i.e., vaginal birth and cesarean section [C-section]) and autism spectrum disorder (ASD) and intellectual disability (ID) risk have reported mixed findings. This study examined ASD and ID risks associated with primary and repeat C-section within diverse US regions. During even years 2000–2016, 8-years-olds were identified with ASD and/or ID and matched to birth records [ASD only (N = 8566, 83.6% male), ASD + ID (N = 3445, 79.5% male), ID only (N = 6158, 60.8% male)] using the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network methodology. The comparison birth cohort (N = 1,456,914, 51.1% male) comprised all births recorded in the National Center for Health Statistics corresponding to birth years and counties in which surveillance occurred. C-section rates in the birth cohort demonstrated significant regional variation with lowest rates in the West. Overall models demonstrate increased odds of disability associated with primary and repeat C-section. Adjusted models, stratified by region, identified significant variability in disability likelihood associated with repeat C-section: increased odds occurred for all case groups in the Southeast, for ASD only and ID only in the Mid-Atlantic, and no case groups in the West. Regional variability in disability risk associated with repeat C-section coincides with differences in birth cohorts' C-section rates. This suggests increased likelihood of disability is not incurred by the procedure itself, but rather C-section serves as a proxy for exposures with regional variability that influence fetal development and C-section rates.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2418-2429"},"PeriodicalIF":5.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding perspectives on figurative language processing in autism spectrum disorder: A commentary on Lampri et al.'s review 拓展自闭症谱系障碍中形象语言处理的视角：对 Lampri 等人综述的评论。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-16 DOI: 10.1002/aur.3249

Yun Tien, Lien-Chung Wei

引用次数: 0

Response to Tien and Wei letter 对 Tien 和 Wei 信件的回复。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-16 DOI: 10.1002/aur.3248

Maria Andreou, Theodoros Marinis, Stella Lampri, Eleni Peristeri

引用次数: 0

Resilience and strengths in the Black autism community in the United States: A scoping review 美国黑人自闭症群体的复原力和优势：范围审查。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-10 DOI: 10.1002/aur.3243

Amber M. Davis, Nicole A. Telfer, Jonet Artis, Oluwatobi Abubakare, Yolanda D. Keller-Bell, Carmen Caruthers, Desiree R. Jones, Nigel P. Pierce

{"title":"Resilience and strengths in the Black autism community in the United States: A scoping review","authors":"Amber M. Davis, Nicole A. Telfer, Jonet Artis, Oluwatobi Abubakare, Yolanda D. Keller-Bell, Carmen Caruthers, Desiree R. Jones, Nigel P. Pierce","doi":"10.1002/aur.3243","DOIUrl":"10.1002/aur.3243","url":null,"abstract":"Gaps in research knowledge pertaining to resiliency factors and strengths among the Black autism community, inclusive of autistic persons and their support system exist. A scoping review was conducted to further explore quantitative, qualitative, and mixed methods studies that investigate resiliency factors and related strengths in the Black autism community in the United States. A total of 436 articles were identified, with 28 studies included in the final review. Results demonstrated that (1) strengths of Black autistic persons across the life course have been disregarded in research; (2) Black caregiver advocacy, while common, is also a developmental process that can be supported by community-based interventions; (3) informal supports including family and friends play an instrumental role in supporting the well-under investigated being of Black parents of autistic children; and (4) spirituality is often endorsed by Black caregivers of autistic children, such as playing a role in acceptance of the autism diagnosis and with coping with difficult life situations. Research and practice implications are discussed.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2198-2222"},"PeriodicalIF":5.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention 比较有效性试验：针对自闭症幼儿的模块化行为疗法与综合行为干预的比较。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-07 DOI: 10.1002/aur.3240

Cynthia Anderson, Samantha Hochheimer, Zachary Warren, Eric Butter, Susan L. Hyman, Hongyue Wang, Lisa Wallace, Lynne Levato, Ryan Martin, Kevin G. Stephenson, Megan Norris, Wynn Jacqueline, Tristram Smith, Cynthia R. Johnson

{"title":"Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention","authors":"Cynthia Anderson, Samantha Hochheimer, Zachary Warren, Eric Butter, Susan L. Hyman, Hongyue Wang, Lisa Wallace, Lynne Levato, Ryan Martin, Kevin G. Stephenson, Megan Norris, Wynn Jacqueline, Tristram Smith, Cynthia R. Johnson","doi":"10.1002/aur.3240","DOIUrl":"10.1002/aur.3240","url":null,"abstract":"This 24-week single-blind trial tested a modular approach for young autistic children (MAYAC) that was delivered for fewer hours per week and modified based on child progress and parental input compared to comprehensive behavioral intervention treatment as usual (CBI, TAU). Participants were autistic children, ages 18–60 months of age. MAYAC was initially 5 h of intervention per week, one of which was parent training and the other four direct therapy focusing on social communication and engagement, but additional modules could be added for up to 10 h per week. Comprehensive behavior intervention was delivered for ≥15 h per week. Outcome measures included the Vineland Adaptive Behavior Scales; VABS, the Ohio Autism Clinical Improvement Scale – Autism Severity; OACIS – AS and the Pervasive Developmental Disorder Behavior Inventory – Parent; PDDBI-P. Implementation and parent satisfaction measures were also collected. Fifty-six children, mean age of 34 months, were randomized. Within-group analysis revealed significant improvements from baseline to week 24 for both MAYAC (p < 0.0001) and CBI, TAU (p < 0.0001) on the VABS. The noninferiority test was performed to test between group differences and MAYAC was not inferior to CBI, TAU on the VABS (p = 0.0144). On the OACIS – AS, 48.0% of MAYAC and 45.5% of CBI were treatment responders there were no significant changes on the PDDBI-P, for either group. Treatment fidelity was high for both groups (>95%) as was parent satisfaction. Findings from this small trial are promising and suggest MAYAC may be an alternative for some young autistic children and their families to CBI, TAU.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2430-2446"},"PeriodicalIF":5.3,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eye-tracking training improves visuospatial working memory of children with attention-deficit/hyperactivity disorder and autism spectrum disorder 眼动跟踪训练可改善注意力缺陷/多动障碍和自闭症谱系障碍儿童的视觉空间工作记忆。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-04 DOI: 10.1002/aur.3238

Agnes S. Chan, Pui-Ying Leung, Tiffany Wing-Yin Pang, Sophia L. Sze

{"title":"Eye-tracking training improves visuospatial working memory of children with attention-deficit/hyperactivity disorder and autism spectrum disorder","authors":"Agnes S. Chan, Pui-Ying Leung, Tiffany Wing-Yin Pang, Sophia L. Sze","doi":"10.1002/aur.3238","DOIUrl":"10.1002/aur.3238","url":null,"abstract":"Given the close connection between eye movement and frontal lobe functions and some evidence supporting the effect of eye-tracking training on enhancing cognitive performance mediated by the frontal lobe, this study aimed to explore if after-school eye-tracking training can improve the visuospatial working memory (VSWM) and cognitive flexibility performance in children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). This study is a non-randomized cluster trial. Forty children from eight primary schools were selected, half receiving eye-tracking training for 20 sessions over 9 months, while the other half served as a waitlist control. They were matched on demographic characteristics and baseline cognitive performance. Their VSWM and cognitive flexibility were assessed at the beginning and end of the study. Results showed that children who received eye-tracking training, but not those on a waitlist, exhibited significant improvements in the total score and working memory span of the VSWM tests, and the correct responses in cognitive flexibility tests. Specifically, VSWM performance at higher span levels (5 or above) yielded a greater improvement. The findings suggest that eye-tracking training can be a feasible and effective after-school program for improving working memory and cognitive flexibility performance in children with ADHD and ASD. This study was prospectively registered at ClinicalTrials.gov (https://clinicaltrials.gov/, trial number: NCT05428657).","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2244-2260"},"PeriodicalIF":5.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal change in symptom severity in children with ASD: Results from the ELENA cohort 自闭症儿童症状严重程度的纵向变化：ELENA队列的研究结果。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-04 DOI: 10.1002/aur.3242

Florine Dellapiazza, Cécile Rattaz, Cécile Michelon, Hugo Peyre, Marie-Christine Picot, Amaria Baghdadli

{"title":"Longitudinal change in symptom severity in children with ASD: Results from the ELENA cohort","authors":"Florine Dellapiazza, Cécile Rattaz, Cécile Michelon, Hugo Peyre, Marie-Christine Picot, Amaria Baghdadli","doi":"10.1002/aur.3242","DOIUrl":"10.1002/aur.3242","url":null,"abstract":"Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition and understanding the changes in autism symptoms over time is crucial for tailoring support and interventions. This study therefore aimed to investigate the changes in symptom severity in a large cohort of children with ASD over a three-year follow-up period and identify factors that influence these changes. The study included 575 children diagnosed with ASD, ranging in age from 2 to 12 years, who were assessed at baseline and again 3 years later using the Autism Diagnostic Observational Schedule-2 (ADOS-2). ASD severity changes were investigated using the ADOS calibrated severity score (CSS) scores for total, social affect (SA) and restricted and repetitive behaviors (RRB). Results highlight four distinct patterns: stable high, stable low, increased, and decreased severity. The ADOS CSS total score changed for half of the sample, reflecting an increase in ASD severity for 21.9% and a decrease for 29.1% of children. For the other half, the ADOS CSS score remained stable, either high (34.4%) or low (14.6%). While the majority of previous studies reported stability in ASD severity, our findings revealed significant variability with frequent improvements in SA symptoms whereas RRBs remained stable or worsened. Our findings also showed that an improvement in SA was associated with the youngest group and early diagnosis. However, no clinical or sociodemographic factors were linked to changes in RRB, emphasizing the necessity for RRB-specific therapies. The third six-year follow-up point of the ongoing ELENA cohort study will map the long-term trajectories of the severity of ASD symptoms and their potential risk factors.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2405-2417"},"PeriodicalIF":5.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast updating of stimulus history reveals weak internal representations of faces in autism 刺激历史的快速更新揭示了自闭症患者薄弱的人脸内部表征。

IF 5.3 2区医学

Autism Research Pub Date : 2024-09-30 DOI: 10.1002/aur.3236

Marissa Hartston, Tal Lulav-Bash, Yael Goldstein-Marcusohn, Galia Avidan, Bat-Sheva Hadad

{"title":"Fast updating of stimulus history reveals weak internal representations of faces in autism","authors":"Marissa Hartston, Tal Lulav-Bash, Yael Goldstein-Marcusohn, Galia Avidan, Bat-Sheva Hadad","doi":"10.1002/aur.3236","DOIUrl":"10.1002/aur.3236","url":null,"abstract":"Atypical perception has been widely reported in autism spectrum disorders, and deficits in face recognition, specifically, are argued to be closely associated with social impairment experienced by these individuals. However, it is still debated (a) whether deficits are perceptually based, and (b) what the role is of experience-based refinements of perceptual face representations in autism. We investigated the effect of short- and long-term experienced stimulus history on face processing. Autistic and non-autistic individuals performed same-different judgments in a serial discrimination task where two consecutive faces were drawn from a distribution of morphed faces. Use of stimulus statistics was measured by testing the gravitation of face representations towards, the mean of a range of morphed faces around which they were sampled (regression-to-the-mean). The results show that unlike non-autistic individuals, representations of own- and other-race faces were equally biased by stimulus statistics in autistic individuals. Moreover, autistic individuals used the most recently exposed faces without forming a strong internal representation based on the overall experienced faces, indicating a weaker internal model of the “typical” averaged face. This accumulated history of faces may underlie typical face specialization, and thus may account for the reduced specialization for own-race faces shown in autism. The results shed light on the way autistic people process and recognize faces, and on the basic mechanisms underlying atypical face perception.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2232-2243"},"PeriodicalIF":5.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autism is associated with in vivo changes in gray matter neurite architecture 自闭症与体内灰质神经元结构的变化有关。

IF 5.3 2区医学

Autism Research Pub Date : 2024-09-26 DOI: 10.1002/aur.3239

Zachary P. Christensen, Edward G. Freedman, John J. Foxe

{"title":"Autism is associated with in vivo changes in gray matter neurite architecture","authors":"Zachary P. Christensen, Edward G. Freedman, John J. Foxe","doi":"10.1002/aur.3239","DOIUrl":"10.1002/aur.3239","url":null,"abstract":"Postmortem investigations in autism have identified anomalies in neural cytoarchitecture across limbic, cerebellar, and neocortical networks. These anomalies include narrow cell mini-columns and variable neuron density. However, difficulty obtaining sufficient post-mortem samples has often prevented investigations from converging on reproducible measures. Recent advances in processing magnetic resonance diffusion weighted images (DWI) make in vivo characterization of neuronal cytoarchitecture a potential alternative to post-mortem studies. Using extensive DWI data from the Adolescent Brain Cognitive Developmentsm (ABCD®) study 142 individuals with an autism diagnosis were compared with 8971 controls using a restriction spectrum imaging (RSI) framework that characterized total neurite density (TND), its component restricted normalized directional diffusion (RND), and restricted normalized isotropic diffusion (RNI). A significant decrease in TND was observed in autism in the right cerebellar cortex (β = −0.005, SE =0.0015, p = 0.0267), with significant decreases in RNI and significant increases in RND found diffusely throughout posterior and anterior aspects of the brain, respectively. Furthermore, these regions remained significant in post-hoc analysis when the autism sample was compared against a subset of 1404 individuals with other psychiatric conditions (pulled from the original 8971). These findings highlight the importance of characterizing neuron cytoarchitecture in autism and the significance of their incorporation as physiological covariates in future studies.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2261-2277"},"PeriodicalIF":5.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0