Autism Research最新文献

{"title":"Autism Research: Thank You to Our 2024 Reviewers","authors":"","doi":"10.1002/aur.3310","DOIUrl":"https://doi.org/10.1002/aur.3310","url":null,"abstract":"","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 1","pages":"9-16"},"PeriodicalIF":5.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding Perspectives on Visual Mental Imagery in Autism: Aphantasia, Enhanced Abilities, and Future Directions","authors":"Lien-Chung Wei, Cheng-Hsien Sung","doi":"10.1002/aur.3311","DOIUrl":"10.1002/aur.3311","url":null,"abstract":"","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"236-237"},"PeriodicalIF":5.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Symptom Burden and Pharmacologic Management of Catatonia in Autism With Intellectual Disability: An Observational Study","authors":"Joshua Ryan Smith,&nbsp;Seri Lim,&nbsp;Snehal Bindra,&nbsp;Sarah Marler,&nbsp;Bavani Rajah,&nbsp;Zachary J. Williams,&nbsp;Isaac Baldwin,&nbsp;Nausheen Hossain,&nbsp;Jo Ellen Wilson,&nbsp;D. Catherine Fuchs,&nbsp;James Luccarelli","doi":"10.1002/aur.3315","DOIUrl":"10.1002/aur.3315","url":null,"abstract":"<p>Catatonia is a highly morbid psychomotor and affective disorder, which can affect autistic individuals with and without intellectual disability. Catatonic symptoms are treatable with pharmacotherapy and electroconvulsive therapy, but the longitudinal effectiveness of these treatments in autistic individuals has not been described. We conducted a prospective observational cohort study of patients with autism and co-morbid catatonia who received outpatient care in a specialized outpatient clinic from July 1, 2021 to May 31, 2024. Data investigating pharmacologic interventions, and clinical measures including the Bush Francis Catatonia Rating Scale (BFCRS), Kanner Catatonia Severity Scale (KCS), Kanner Catatonia Examination (KCE), and Clinical Global Impression—Improvement (CGI-I) were collected. Forty-five autistic patients with co-morbid catatonia were treated during the study period. The mean age was 15.6 (SD = 7.9) years [Mdn = 16.0, range 6.0–31.0]. Forty-one patients (91.1%) met criteria for autism with co-occurring intellectual disability. All patients received pharmacotherapy. Forty-four (97.8%) were treated with benzodiazepines with a mean maximal daily dose of 17.4 mg (SD = 15.8) lorazepam equivalents. Thirty-five patients (77.8%) required more than one medication class for treatment. Sixteen (35.6%) patients received electroconvulsive therapy. Fourteen patients (31.1%) attempted to taper off benzodiazepines after achieving clinical improvement during the study period; of these, 5 patients (11.1%) were successfully tapered off, and the remaining 9 (17.8%) discontinued the taper due to a return of catatonic symptoms. Statistically significant improvement was observed across all clinical domains except the KCS. However, the majority remained at least partially symptomatic over the study period. Three patients (6.7%) died over the study period. Despite clinical improvements while receiving the gold standard for psychopharmacologic management of catatonia, chronic symptoms remained for the majority of catatonia patients over the study period, and few were able to taper and discontinue benzodiazepine treatment. Notably, the open label design of this study is a limiting factor when interpreting the results.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"449-462"},"PeriodicalIF":5.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What We Publish and What We Do Not","authors":"David G. Amaral,&nbsp;the Associate Editors","doi":"10.1002/aur.3307","DOIUrl":"10.1002/aur.3307","url":null,"abstract":"&lt;p&gt;The editors of &lt;b&gt;\u0000 &lt;i&gt;Autism Research&lt;/i&gt;\u0000 &lt;/b&gt; would like to wish you a healthy, happy, and productive 2025. &lt;i&gt;If you consider publishing a paper in the journal in the future, please read the following&lt;/i&gt;:&lt;/p&gt;&lt;p&gt;During 2024, we received an unprecedented number of submissions to &lt;i&gt;Autism Research&lt;/i&gt;. We thank the authors and the reviewers for their support of the journal. We also received an unusually large number of submissions that were not consistent with the aims and scope of the journal and, therefore, were not suitable for publication in the journal. For many of these, it appears that the authors had not fully reviewed the Author Guidelines, which can be found by clicking the “Contribute” button on the blue banner on the journal home page. This takes authors to the following link (https://onlinelibrary.wiley.com/page/journal/19393806/homepage/forauthors.html).&lt;/p&gt;&lt;p&gt;To be fully informed about the types of submission most likely to be published in &lt;i&gt;Autism Research&lt;/i&gt;, we would encourage potential authors to review the instructions in full and to pay special attention to the second section “2. Aims &amp; Scope” of the Author Guidelines. &lt;b&gt;This section is there to help you determine whether your article is appropriate for the journal&lt;/b&gt;. In the text below, we summarize some of the important inclusion and exclusion criteria for submitted papers.&lt;/p&gt;&lt;p&gt;The journal focuses on reports of novel findings related to genetic, neurobiological, immunological, medical, epidemiological, and psychological mechanisms and how these influence developmental processes in autism spectrum disorder. The journal encourages the submission of original research papers (Research Articles and Short Reports) that take a developmental approach to the biology and psychology of autism, with a particular emphasis on identifying underlying mechanisms and integrating across different levels of analysis. Contributions are typically empirical, but the journal also publishes theoretical papers if they significantly advance thinking. The journal encourages papers reporting work on animal, cell, or other model systems that are directly relevant to a better understanding of autism or related conditions. The journal also publishes reports of carefully conducted clinical trials of treatments for the core symptoms or one of the common co-occurring conditions of autism.&lt;/p&gt;&lt;p&gt;For papers submitted to &lt;i&gt;Autism Research&lt;/i&gt;, a &lt;b&gt;clinical trial&lt;/b&gt; is defined as any research study that prospectively assigns human participants or groups to one or more interventions to evaluate the effects of those interventions on &lt;b&gt;health-related biomedical or behavioral outcomes&lt;/b&gt;. Health-related interventions include drugs, surgical procedures, devices, behavioral treatments, dietary interventions, or educational programs. By this definition, an equine or animal-assisted intervention would be considered a clinical trial. Health outcomes include any biomedical ","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 1","pages":"7-8"},"PeriodicalIF":5.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gross Motor Development in Children With Autism: Longitudinal Trajectories From the Growing Up in New Zealand Study","authors":"Paula Araya,&nbsp;Katrina Phillips,&nbsp;Karen Waldie,&nbsp;Lisa Underwood","doi":"10.1002/aur.3304","DOIUrl":"10.1002/aur.3304","url":null,"abstract":"<p>This study explored gross motor development (GMD) trajectories among 6359 children, with and without autism, from the <i>Growing Up in New Zealand</i> longitudinal cohort study. By the age of 8, 173 children had either an autism diagnosis (<i>n</i> = 108) or parent-reported autism concerns (<i>n</i> = 65). Gross motor milestones were reported by mothers when children were 9, 24, and 54 months of age. We found that irrespective of autism diagnosis, GMD delays at 24 months of age were more likely among girls, children born preterm, and those whose mothers identified as European. A mixed-effect logistic regression model, controlling for antenatal maternal and child covariates, revealed that the proportion of children with GMD delay (relative to their peers) increased significantly from 9 to 54 months for all three groups, but the increase was greater for those with autism concerns (OR = 1.28, 95% CI = 1.08–1.52) or an autism diagnosis (OR = 1.26, 95% CI = 1.10–1.43) compared to the no autism group (OR = 1.06, 95% CI = 1.02–1.10). Differences in the changes in GMD performance among children with an autism diagnosis compared to those without autism occurred between 9 and 24 months (OR = 2.16, 95% CI = 1.13–4.13). No significant GMD delay differences were found at any time between children with an autism diagnosis versus those with autism concerns. Children with a GMD delay should be screened for autism at 24 m. Early identification is the first step toward knowledge-based, effective intervention of developmental difficulties.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"437-448"},"PeriodicalIF":5.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between service receipt during the COVID-19 pandemic and autistic children's multisystem outcomes and autism severity: A SPARK dataset analysis","authors":"Jung-Mei Tsai,&nbsp;Anjana Bhat","doi":"10.1002/aur.3256","DOIUrl":"10.1002/aur.3256","url":null,"abstract":"<p>Children with autism spectrum disorder (ASD) display a variety of core and co-occurring difficulties in social, communication, everyday functioning, cognitive, motor, and language domains. Receiving a combination of services to accommodate needs of autistic individuals is essential for improving their future outcomes. During the COVID-19 pandemic, reduced service access negatively impacted autistic children's outcomes. This study aimed to examine the relationship between service receipt and parental perceived outcomes in autistic children while accounting for various demographic, child, and parental factors. We utilized parental COVID-19 impact survey data from the SPARK study (<i>N</i> = 6067). Ordinal logistic regression analyses were used to predict perceived child outcomes. Demographic, child, and parental factors were included in the prediction models. Service receipt of SLT, ABA, PT/OT, MED, and MH were associated with perceived child outcomes. PT/OT and ABA predicted improvements in domains of social interaction, everyday activity, and overall autism severity; SLT and ABA contributed to improved perceived communication outcomes. Receiving MH and MED services was associated with worsening of perceived outcomes on all domains. Younger age, males, higher family income, lower autism severity, lower motor, function, and cognitive delay, greater language delay, and the absence of parental mental health issues were associated with greater improvements in various perceived outcomes. Overall, PT/OT and ABA services are associated with improved perceived social and functional outcomes whereas SLT and ABA services are associated with improved perceived communication outcomes. We also provide a wholistic view of factors affecting relationships between service receipt and perceived child outcomes during the pandemic.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 1","pages":"217-229"},"PeriodicalIF":5.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder","authors":"Yu Wang,&nbsp;Aihua Cao,&nbsp;Jing Wang,&nbsp;He Bai,&nbsp;Tianci Liu,&nbsp;Chenxi Sun,&nbsp;Zhuoran Li,&nbsp;Yuchun Tang,&nbsp;Feifei Xu,&nbsp;Shuwei Liu","doi":"10.1002/aur.3287","DOIUrl":"10.1002/aur.3287","url":null,"abstract":"<p>The cerebellum plays a crucial role in functions, including sensory-motor coordination, cognition, and emotional processing. Compared to the neocortex, the human cerebellum exhibits a protracted developmental trajectory. This delayed developmental timeline may lead to increased sensitivity of the cerebellum to external influences, potentially extending the vulnerability period for neurological disorders. Abnormal cerebellar development in individuals with autism has been confirmed, and these atypical cerebellar changes may affect the development of the neocortex. However, due to the heterogeneity of autism spectrum disorder (ASD), the regional changes in the cerebellum and cerebellocerebral structural relationship remain unknown. To address these issues, we utilized imaging methods optimized for the cerebellum and cerebrum on 817 individuals aged 5–18 years in the ABIDE II dataset. After FDR correction, significant differences between groups were found in the right crus II/VIIB and vermis VI-VII. Structural covariance analysis revealed enhanced structural covariance in individuals with autism between the cerebellum and parahippocampal gyrus, pars opercularis, and transverse temporal gyrus in the right hemisphere after FDR correction. Furthermore, the structural covariance between the cerebellum and some regions of the cerebrum varied across sexes. A significant increase in structural covariance between the cerebellum and specific subcortical structures was also observed in individuals with ASD. Our study found atypical patterns in the structural covariance between the cerebellum and cerebrum in individuals with autism, which suggested that the underlying pathological processes of ASD might concurrently affect these brain regions. This study provided insight into the potential of cerebellocerebral pathways as therapeutic targets for ASD.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 1","pages":"83-97"},"PeriodicalIF":5.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust Autism Spectrum Disorder-Related Spatial Covariance Gray Matter Pattern Revealed With a Large-Scale Multi-Center Dataset","authors":"Sheng-Zhi Ma,&nbsp;Xing-Ke Wang,&nbsp;Chen Yang,&nbsp;Wen-Qiang Dong,&nbsp;Dan-Dan Chen,&nbsp;Chao Song,&nbsp;Qiu-Rong Zhang,&nbsp;Yu-Feng Zang,&nbsp;Li-Xia Yuan","doi":"10.1002/aur.3303","DOIUrl":"10.1002/aur.3303","url":null,"abstract":"<div>\u0000 \u0000 <p>Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder and its underlying neuroanatomical mechanisms still remain unclear. The scaled subprofile model of principal component analysis (SSM-PCA) is a data-driven multivariate technique for capturing stable disease-related spatial covariance pattern. Here, SSM-PCA is innovatively applied to obtain robust ASD-related gray matter volume pattern associated with clinical symptoms. We utilized T1-weighted structural MRI images (sMRI) of 576 subjects (288 ASDs and 288 typically developing (TD) controls) aged 7–29 years from the Autism Brain Imaging Data Exchange II (ABIDE II) dataset. These images were analyzed with SSM-PCA to identify the ASD-related spatial covariance pattern. Subsequently, we investigated the relationship between the pattern and clinical symptoms and verified its robustness. Then, the applicability of the pattern under different age stages were further explored. The results revealed that the ASD-related pattern primarily involves the thalamus, putamen, parahippocampus, orbitofrontal cortex, and cerebellum. The expression of this pattern correlated with Social Response Scale and Social Communication Questionnaire scores. Moreover, the ASD-related pattern was robust for the ABIDE I dataset. Regarding the applicability of the pattern for different age stages, the effect sizes of its expression in ASD were medium in the children and adults, while small in adolescents. This study identified a robust ASD-related pattern based on gray matter volume that is associated with social deficits. Our findings provide new insights into the neuroanatomical mechanisms of ASD and may facilitate its future intervention.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"312-324"},"PeriodicalIF":5.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Regional Accent in Autistic Children: A Perception Study","authors":"Federica Beccaria,&nbsp;Gloria Gagliardi,&nbsp;Mikhail Kissine","doi":"10.1002/aur.3300","DOIUrl":"10.1002/aur.3300","url":null,"abstract":"<p>Autistic children are frequently said to speak with accents that markedly differ from those of their linguistic communities. To date, these anecdotal reports have never been tested or explained. We ran two perception studies using short audio recordings of autistic and typically developing children from the Campania region in Italy. The variety of Italian to which children are exposed in this region markedly differs from those spoken in the rest of Italy. Participant responses about the children's geographical origin show: (a) That autistic children's accent is devoid of the regional features of their community; (b) resembles the standard variety used in cartoons and child television programs. The judgments about children's accents are, furthermore, independent of the overall perception of speech atypicality. This paper shows that the accent of autistic children may diverge from that of their caregivers and peers because of the lasting influence of non-interactional, screen sources on their speech.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"415-426"},"PeriodicalIF":5.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Serum Manganese, Zinc, Copper, and Selenium Concentrations With Autism Spectrum Disorders in Chinese Children: A Case–Control Study","authors":"Yong Zhang,&nbsp;Fang Xie,&nbsp;Sheng Li,&nbsp;Ying Li,&nbsp;Liting Yang,&nbsp;Zhen Wang,&nbsp;Jinlin Lei,&nbsp;Huailan Guo","doi":"10.1002/aur.3302","DOIUrl":"10.1002/aur.3302","url":null,"abstract":"<div>\u0000 \u0000 <p>Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case–control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD. Compared with TD, ASD has lower Zn and Se levels and higher Cu levels. The restricted cubic spline model showed J-shaped non-linearity, L-shaped non-linearity, and positive linearity correlations between Mn, Zn, Cu, and ASD. Zn and Cu were negatively and positively correlated with ASD symptoms, respectively. The superoxide dismutase (SOD) mediated 50.53% and 39.07% of the association between Zn, Se, and ASD, respectively. Bayesian kernel machine regression (BKMR) confirmed a U-shaped correlation between the element mixtures and ASD. Interactions of Mn with the other three elements and Cu with Zn were also observed. Our results confirm that the independent and combined exposure to the four trace elements was associated with ASD, with oxidative stress being an important mechanism. Due to the potential interactions between the elements, further research is needed to explore their involvement in the pathogenesis and progression of ASD from a combined perspective, as well as the beneficial and harmful concentration ranges.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 2","pages":"427-436"},"PeriodicalIF":5.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}