Autism Research最新文献_第2页

A systematic review and meta-analysis of atypical visual attention towards non-social stimuli in preschoolers with autism spectrum disorder 自闭症谱系障碍学龄前儿童对非社交刺激的非典型视觉注意力的系统回顾和荟萃分析。

IF 5.3 2区医学

Autism Research Pub Date : 2024-11-06 DOI: 10.1002/aur.3261

Julian R. Hinz, Fillip F. Eikeseth, Katarzyna Chawarska, Svein Eikeseth

{"title":"A systematic review and meta-analysis of atypical visual attention towards non-social stimuli in preschoolers with autism spectrum disorder","authors":"Julian R. Hinz, Fillip F. Eikeseth, Katarzyna Chawarska, Svein Eikeseth","doi":"10.1002/aur.3261","DOIUrl":"10.1002/aur.3261","url":null,"abstract":"Research on attention towards non-social stimuli in preschoolers with autism spectrum disorder (ASD) has increased over the past decade; however, findings have been inconsistent. It has been suggested that stimuli relating to common circumscribed interests (CIs) elicit more attention than non-CI related stimuli. This meta-analysis synthesizes results from 31 studies that compared attention towards non-social stimuli in children with ASD under the age of five with typically developing (TD) controls using eye-tracking. Additional subgroup analysis comparing studies that employed non-social stimuli related to CIs frequently reported in adults with ASD to studies using non-CI related stimuli were conducted. Meta-regressions with age, sex, stimulus dimension, nonverbal DQ, and symptom severity were conducted. Results show small (g = 0.39) but significantly higher attention towards non-social stimuli for the ASD group. However, when studies were split based on stimulus type no significant differences for non-CI related stimuli was found. Meanwhile studies employing CI related stimuli reported significant large effects on attention allocation (g = 0.69). None of the conducted regressions reached significance. The findings show increased non-social attention in children with ASD is driven by CI related content rather than a general non-social attentional bias. The findings and future research directions are discussed.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 12","pages":"2628-2644"},"PeriodicalIF":5.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What role does the environment play in language development? Exploring the associations among socioeconomic status, parent language input, and language skills in school-aged children with autism 环境在语言发展中扮演什么角色？探索自闭症学龄儿童的社会经济地位、父母语言输入和语言技能之间的关联。

IF 5.3 2区医学

Autism Research Pub Date : 2024-11-04 DOI: 10.1002/aur.3252

Meredith Pecukonis, Lindsay K. Butler, Helen Tager-Flusberg

{"title":"What role does the environment play in language development? Exploring the associations among socioeconomic status, parent language input, and language skills in school-aged children with autism","authors":"Meredith Pecukonis, Lindsay K. Butler, Helen Tager-Flusberg","doi":"10.1002/aur.3252","DOIUrl":"10.1002/aur.3252","url":null,"abstract":"Language development in children with autism is influenced by proximal (e.g., parent language input) and distal (e.g., socioeconomic status) environmental constructs. Studies have found that “rich and responsive” parent language input supports autistic children's language development, and recent work has reported positive associations between measures of socioeconomic status (SES) and child language skills. However, little is known about how these proximal and distal environmental constructs interact to shape language development in autism. In a sample of 74 autistic school-aged children, the present study investigated the associations among measures of SES, the quantity and quality of language produced by parents and children during home-based dyadic parent–child interactions, and children's expressive and receptive language skills. Results showed that annual household income was positively associated with parent number of total words (NTW), parent number of different words (NDW), and parent mean length of utterance (MLU), while neither parent education level nor annual household income were significantly associated with measures of child language skills. Parent MLU was positively associated with child MLU and child expressive language skills. Findings suggest that annual household income may influence both the quantity and quality of parent language input, and that parent MLU, a qualitative measure of parent language input, may play a particularly important role in shaping autistic children's expressive language development. Future research should study longitudinal associations among SES, parent language input, and child language skills, as identifying environmental predictors of language skills in autism may facilitate the creation of more effective interventions that support language development.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 12","pages":"2614-2627"},"PeriodicalIF":5.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parental age at birth, telomere length, and autism spectrum disorders in the UK Biobank cohort 英国生物库队列中父母的出生年龄、端粒长度和自闭症谱系障碍。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-30 DOI: 10.1002/aur.3258

Qiaofeng Ye, Abner T. Apsley, Waylon J. Hastings, Laura Etzel, Craig Newschaffer, Idan Shalev

{"title":"Parental age at birth, telomere length, and autism spectrum disorders in the UK Biobank cohort","authors":"Qiaofeng Ye, Abner T. Apsley, Waylon J. Hastings, Laura Etzel, Craig Newschaffer, Idan Shalev","doi":"10.1002/aur.3258","DOIUrl":"10.1002/aur.3258","url":null,"abstract":"Older parental age at birth is associated with increased risk of autism spectrum disorders (ASD) in offspring. Independently, shorter telomere length (TL) has also been shown to be associated with ASD in children. However, older paternal age at birth, with or without controlling for maternal age, has been associated with longer TL, a seemingly contradictory finding. Here, we conducted a retrospective cohort study among participants in the UK Biobank to disentangle associations between leukocyte TL and ASD status in adults, and the potential moderation by parental age on adult offspring's TL. Participants with ASD diagnosis (N = 87) with a mean age of 46.0 (SD 4.4) years were matched to participants without ASD diagnosis (N = 870) based on age, sex, ethnicity, education, household income, and assessment center. No statistically significant differences were seen in TL between participants with and without ASD when parental age at birth was not considered. However, there was a significant interaction between ASD diagnostic status and parental age on participants' TL, such that older paternal or maternal age at birth was more strongly associated with longer TL in participants with ASD. This study suggests that the shortened TL observed in children with ASD in previous research may partially depend on parental age at birth. Future studies tracking TL attrition before ASD diagnosis are warranted to depict temporal associations and the interacting effects of parental age at birth and ASD status on TL across the lifespan.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2223-2231"},"PeriodicalIF":5.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.3258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent predictors of behavioral inflexibility in minimally verbal and verbal autistic children 自闭症儿童中最小言语障碍和言语障碍行为不灵活的并发预测因素。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-30 DOI: 10.1002/aur.3251

Charlotte Gaynor, Yanru Chen, Helen Tager-Flusberg

{"title":"Concurrent predictors of behavioral inflexibility in minimally verbal and verbal autistic children","authors":"Charlotte Gaynor, Yanru Chen, Helen Tager-Flusberg","doi":"10.1002/aur.3251","DOIUrl":"10.1002/aur.3251","url":null,"abstract":"Behavioral inflexibility (BI) refers to the rigid and inflexible patterns of behaviors that are a core aspect of autism. Few studies have investigated BI in autism separately from other restricted and repetitive behaviors (RRBs). The present study used a relatively new measure, the behavioral inflexibility scale (BIS; Lecavalier, L., Bodfish, J., Harrop, C., Whitten, A., Jones, D., Pritchett, J., Faldowski, R., & Boyd, B. (2020). Autism Research, 13(3), 489–499), to examine the relationship of BI and variables that are both core symptoms in autism as well as symptoms associated with cooccurring mental health conditions, atypical sensory experiences, and adaptive functioning in a sample of 87 children with autism. Additionally, we aimed to understand how these relationships may be related to autistic individuals' verbal status: minimally verbal (MV) or verbal. Results revealed that anxiety, attention deficit/hyperactive, depressive, oppositional defiance problems, and sensory differences were all significantly correlated with BI in the MV group. In contrast, only anxiety, depressive, and oppositional defiance problems were significantly correlated with BI in the verbal group. Linear regression analyses showed that oppositional defiance problems and atypical sensory experiences explained a significant proportion of the variance of BI in the MV group, whereas only depressive problems were significant in the verbal group after accounting for other mental health conditions. Overall, our findings demonstrate that multiple aspects of psychopathology are significantly related to BI and can have broader implications for interventions and mental health care in autistic children.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 12","pages":"2602-2613"},"PeriodicalIF":5.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring autism with the ADOS-2 using a bifactor model 使用双因素模型用 ADOS-2 测量自闭症。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-25 DOI: 10.1002/aur.3245

Phebe Albert, Gal Kaldes, Erin Tully, MaryAnn Romski, Robin D. Morris, Rose A. Sevcik, Laura Dilly

{"title":"Measuring autism with the ADOS-2 using a bifactor model","authors":"Phebe Albert, Gal Kaldes, Erin Tully, MaryAnn Romski, Robin D. Morris, Rose A. Sevcik, Laura Dilly","doi":"10.1002/aur.3245","DOIUrl":"10.1002/aur.3245","url":null,"abstract":"The measurement of autism characteristics can be challenging due to variability of social impairments and restricted and repetitive behaviors or interests (RRBs). Psychometrically strong measures such as the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) can improve our capacity for thorough autism assessment. The conceptualization of the ADOS-2 has been shaped by research exploring the structure of its items, which evaluate autism traits associated with social affect and RRBs. Continuously refining our understanding of these items and their relations to other characteristics, such as cognition, is crucial for more accurate autism assessment and diagnosis. This study used data from a sample of 188 school-age children with mostly average cognitive functioning referred for clinical autism evaluations to (1) test the dimensionality of the ADOS-2, Module 3 (appropriate for children with relatively higher verbal ability), across two sets of items (i.e., algorithm only, algorithm with three non-algorithm RRB items) using confirmatory factor analysis (CFA) and (2) examine the relations of cognition to the dimensions tested in the ADOS-2. A bifactor model, featuring a general autism trait and two subfactors (RRB and Social Affect), provided superior fit for algorithm-only and algorithm with three non-algorithm items. Cognitive functioning was not significantly related to the general or specific factors in the model with only algorithm items. While the findings support the validity of the ADOS-2, it may not fully capture RRBs among children referred for autism. This study enhances our understanding of the ADOS-2, highlighting the utility of a bifactor model for characterizing its dimensionality, measuring autism traits with minimal cognitive influence, and identifying its limitations in assessing RRBs.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 12","pages":"2487-2502"},"PeriodicalIF":5.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional differences in autism and intellectual disability risk associated with cesarean section delivery 与剖腹产有关的自闭症和智障风险的地区差异。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-17 DOI: 10.1002/aur.3247

Deborah A. Bilder, Scott Sullivan, Michelle M. Hughes, Susan Dalton, Jennifer Hall-Lande, Connor Nicholls, Amanda V. Bakian

{"title":"Regional differences in autism and intellectual disability risk associated with cesarean section delivery","authors":"Deborah A. Bilder, Scott Sullivan, Michelle M. Hughes, Susan Dalton, Jennifer Hall-Lande, Connor Nicholls, Amanda V. Bakian","doi":"10.1002/aur.3247","DOIUrl":"10.1002/aur.3247","url":null,"abstract":"Prior epidemiological studies investigating the association between delivery mode (i.e., vaginal birth and cesarean section [C-section]) and autism spectrum disorder (ASD) and intellectual disability (ID) risk have reported mixed findings. This study examined ASD and ID risks associated with primary and repeat C-section within diverse US regions. During even years 2000–2016, 8-years-olds were identified with ASD and/or ID and matched to birth records [ASD only (N = 8566, 83.6% male), ASD + ID (N = 3445, 79.5% male), ID only (N = 6158, 60.8% male)] using the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network methodology. The comparison birth cohort (N = 1,456,914, 51.1% male) comprised all births recorded in the National Center for Health Statistics corresponding to birth years and counties in which surveillance occurred. C-section rates in the birth cohort demonstrated significant regional variation with lowest rates in the West. Overall models demonstrate increased odds of disability associated with primary and repeat C-section. Adjusted models, stratified by region, identified significant variability in disability likelihood associated with repeat C-section: increased odds occurred for all case groups in the Southeast, for ASD only and ID only in the Mid-Atlantic, and no case groups in the West. Regional variability in disability risk associated with repeat C-section coincides with differences in birth cohorts' C-section rates. This suggests increased likelihood of disability is not incurred by the procedure itself, but rather C-section serves as a proxy for exposures with regional variability that influence fetal development and C-section rates.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 11","pages":"2418-2429"},"PeriodicalIF":5.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing 自闭症和神经畸形青少年产前暴露于缺氧风险条件下：相关心室差异、睡眠障碍和感觉处理。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-16 DOI: 10.1002/aur.3250

Cristian Preciado, Maria Baida, Yi Li, Yan Li, Carly Demopoulos

{"title":"Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing","authors":"Cristian Preciado, Maria Baida, Yi Li, Yan Li, Carly Demopoulos","doi":"10.1002/aur.3250","DOIUrl":"10.1002/aur.3250","url":null,"abstract":"There is a growing body of research that suggests conditions during the period of pregnancy and birth can affect how autism spectrum disorder (ASD) presents itself. This study aimed to investigate the incidence of oxygen deprivation during this period known as prenatal and perinatal hypoxic risk (HR) conditions in ASD compared with neurotypical control (NTC) youth. We also examined ventricular morphology variations associated with HR exposure, and to evaluate associations with clinical symptoms. Results from a cohort of 104 youth revealed a higher incidence of exposure to prenatal hypoxic conditions in the ASD group. Additionally, ASD individuals with prenatal hypoxic exposure (ASD + HR) demonstrated larger third ventricle volumes compared with both ASD and NTC individuals without such exposure (ASD-HR and NTC-HR, respectively). Furthermore, associations were identified between prenatal hypoxic exposure, third ventricle volume, sensory dysfunction, and severity of sleep disturbances. These findings suggest exposure to prenatal hypoxic risk conditions may exacerbate or modify the neurodevelopmental trajectory and symptom severity in ASD, emphasizing the need for better prenatal care and specific interventions to reduce these risks.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 12","pages":"2547-2557"},"PeriodicalIF":5.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding perspectives on figurative language processing in autism spectrum disorder: A commentary on Lampri et al.'s review 拓展自闭症谱系障碍中形象语言处理的视角：对 Lampri 等人综述的评论。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-16 DOI: 10.1002/aur.3249

Yun Tien, Lien-Chung Wei

引用次数: 0

Response to Tien and Wei letter 对 Tien 和 Wei 信件的回复。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-16 DOI: 10.1002/aur.3248

Maria Andreou, Theodoros Marinis, Stella Lampri, Eleni Peristeri

引用次数: 0

Interceptive abilities in autism spectrum disorder: Comparing naturalistic and virtual visuomotor tasks 自闭症谱系障碍的感知能力：比较自然任务和虚拟视觉运动任务。

IF 5.3 2区医学

Autism Research Pub Date : 2024-10-16 DOI: 10.1002/aur.3246

Se-Woong Park, Annie Cardinaux, Dena Crozier, Marta Russo, Sabrina Bond, Margaret Kjelgaard, Pawan Sinha, Dagmar Sternad

{"title":"Interceptive abilities in autism spectrum disorder: Comparing naturalistic and virtual visuomotor tasks","authors":"Se-Woong Park, Annie Cardinaux, Dena Crozier, Marta Russo, Sabrina Bond, Margaret Kjelgaard, Pawan Sinha, Dagmar Sternad","doi":"10.1002/aur.3246","DOIUrl":"10.1002/aur.3246","url":null,"abstract":"A growing body of research reveals that autistic individuals exhibit motor coordination challenges. Multiple theoretical frameworks propose that the seemingly disparate features of autism may arise from a common underlying process: a diminished ability to make predictions. Sensorimotor skills, such as catching a ball, critically rely on predicting the ball's trajectory as well as anticipatory coordination of the entire body. Here, we assessed four different naturalistic and virtual interception tasks with 31 neurotypical and 23 autistic children (ages 7–12). In a naturalistic setting, participants caught the ball either with their hands or a hand-held funnel with an enlarged catch area that also prevented the ball from bouncing off. A virtual setup reduced whole-body demands, as children only moved a paddle to catch or bounce a ball on a screen. Control tasks, involving rapid reaching to grasp a static object and quiet standing, which largely eliminated the requirements for prediction, were also tested. Results from all task variations demonstrated that autistic children completed fewer successful interceptions, suggesting that predictive requirements, inherent to all interception tasks, played a critical role. Effect sizes in the virtual tasks were smaller. Correlations of the task metrics with behavioral assessments rendered the strongest correlations with Praxis scores. The control tasks showed no differences between autistic and neurotypical children. These findings lend support to the emerging hypothesis that predictive challenges are present in autism. Further research with larger sample sizes will help identify to what extent these visuomotor differences may inform core domains of autism.","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"17 12","pages":"2514-2534"},"PeriodicalIF":5.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0