Autism Research最新文献

{"title":"Building Capacity: A Systematic Review of Training in the Diagnosis of Autism for Community-Based Clinicians","authors":"Jessica V. Smith,&nbsp;Mya Howard,&nbsp;Michelle Menezes,&nbsp;Christina Burroughs,&nbsp;Jessica Pappagianopoulos,&nbsp;Vibha Sastri,&nbsp;Sophie Brunt,&nbsp;Ryan Miller,&nbsp;Anzhelika Parenchuk,&nbsp;Jocelyn Kuhn,&nbsp;Micah O. Mazurek","doi":"10.1002/aur.70014","DOIUrl":"10.1002/aur.70014","url":null,"abstract":"<p>In an effort to reduce the “waitlist crisis,” researchers have developed training programs to educate community-based clinicians in best-practice autism diagnostic assessments. This systematic review aims to synthesize the effectiveness and implementation outcomes of such trainings. The following databases were searched from inception until August 2023: PubMed, Web of Science, APA PsycINFO, CINAHL, ERIC, and a select number from Google Scholar. Ten studies were included in the present review because they met the following criteria: development and/or evaluation of a training for practicing community-based clinicians to diagnose autism, published full-text in English, and original research. Risk of bias was assessed through an adapted NIH quality assessment tool. Only seven distinct training programs in autism diagnosis for practicing community-based clinicians were identified. Trainings demonstrated preliminary efficacy in the improvement of clinician knowledge, self-efficacy, practice behavior, and diagnostic accuracy. Many of the trainings had a reported positive impact on the community and were feasible to participate in; however, systems-level factors (e.g., time and reimbursement) remain as barriers to community-based diagnosis. Findings from the present review position clinician training as a promising strategy to increase families' timely access to an autism diagnosis. More research on training models is needed due to both the limited number of trainings and the limited reported effectiveness and implementation outcomes. Future implementation studies are also needed to reduce systems-level barriers and to aid in the determination of what trainings best fit the needs of different contexts.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"690-709"},"PeriodicalIF":5.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Camera Movement Impacts on Mu-Wave Activity During Action Observation in Adults With Autism Spectrum Disorders Without Intellectual Disabilities","authors":"Veronica Nisticò,&nbsp;Renata del Giudice,&nbsp;Francesca Serio,&nbsp;Giovanni Boido,&nbsp;Gianmarco Ingrosso,&nbsp;Francesco Lombardi,&nbsp;Claudio Sanguineti,&nbsp;Valeria Casula,&nbsp;Adelaide Baccara,&nbsp;Elia Chiudinelli,&nbsp;Francesca Vairano,&nbsp;Federica Maria Panzeri,&nbsp;Mauro Giori,&nbsp;Paolo Maria Inghilleri di Villadauro,&nbsp;Raffaella Faggioli,&nbsp;Orsola Gambini,&nbsp;Tomaso Subini,&nbsp;Benedetta Demartini","doi":"10.1002/aur.70012","DOIUrl":"10.1002/aur.70012","url":null,"abstract":"<p>The aim of this study was to investigate differences in mu-wave modulation in individuals diagnosed with autism spectrum disorder (ASD) without intellectual disabilities compared to a group of neurotypical controls (NT). Thirty autistic individuals and 30 NT underwent an EEG recording while watching short videos depicting goal-oriented action filmed from a fixed position, zooming in on the scene, and approaching the scene by means of a steadycam. Then, participants underwent a rating task to evaluate their subjective viewing experience. We found that steadycam videos elicited enhanced event-related desynchronization (ERD), suggestive of enhanced neural activity, in the NT group, and a reduced ERD in the autistic group, compared to the other filming conditions. Autistic participants also showed difficulties in returning to baseline mu-power levels after watching videos filmed from a fixed position. Finally, NT reported feeling more comfortable watching videos with movement, whereas autistic participants did not exhibit differences between conditions. We speculated that static, less naturalistic stimuli might impose higher and prolonged cognitive demands on autistic individuals. Understanding these differences might help develop tailored interventions to support perceptual, cognitive, and social processes of autistic people.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"774-787"},"PeriodicalIF":5.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Developmental Patterns of Sensorimotor-Related Networks in Autism Spectrum Disorder: A BrainAGE Study Based on Resting-State fMRI","authors":"Yifei Wu,&nbsp;Chunying Lu,&nbsp;Min Li,&nbsp;Bowen Li,&nbsp;Xing Shang,&nbsp;Guifen Jian,&nbsp;Qianyue Zhang,&nbsp;Xue Chen,&nbsp;Xuan Cao,&nbsp;Bifang He,&nbsp;Jia Wang,&nbsp;Heng Liu,&nbsp;Heng Chen","doi":"10.1002/aur.70008","DOIUrl":"10.1002/aur.70008","url":null,"abstract":"<div>\u0000 \u0000 <p>Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder characterized by atypical brain development. Previous whole-brain BrainAGE studies have unveiled the presence of accelerated or delayed brain function developmental patterns in individuals with ASD. However, it remains unclear whether these patterns manifest at a global level throughout the entire brain or are specific to certain functional sub-networks. The study included resting-state functional magnetic resonance imaging (fMRI) data from 127 individuals with ASD and 135 healthy controls (aged between 5 and 40 years). ALFF maps were measured for each participant. Then, sub-network-level BrainAGE analyses were conducted across 10 sub-networks using the Individual-weighted Multilayer Perceptron Network (ILWMLP) regression method. The BrainAGE analyses revealed atypical developmental trajectories in sensorimotor-related sub-networks, encompassing auditory, motor, and sensorimotor sub-networks. In individuals with ASD, delayed brain function development was observed in the auditory and sensorimotor networks, with a more pronounced delay observed in older individuals. Conversely, the motor network exhibited accelerated development in younger individuals but delayed development in older individuals. Our findings unveiled aberrant developmental patterns in sensorimotor-related sub-networks among individuals with ASD, exhibiting distinct atypical profiles across different sub-networks. These results might contribute to a deeper understanding of the deviant brain development observed in ASD.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"765-773"},"PeriodicalIF":5.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social–Emotional Reciprocity in Autistic Adults","authors":"Kristína Czekóová,&nbsp;Radek Mareček,&nbsp;Rostislav Staněk,&nbsp;Calum Hartley,&nbsp;Klaus Kessler,&nbsp;Pavlína Hlavatá,&nbsp;Hana Ošlejšková,&nbsp;Milan Brázdil,&nbsp;Daniel Joel Shaw","doi":"10.1002/aur.70010","DOIUrl":"10.1002/aur.70010","url":null,"abstract":"<p>To identify the neurocognitive mechanisms underpinning the social difficulties that characterize autism, we performed functional magnetic resonance imaging on pairs of autistic and non-autistic adults simultaneously whilst they interacted with one another on the iterated Ultimatum Game (iUG)—an interactive task that emulates the reciprocal characteristic of naturalistic interpersonal exchanges. Two age-matched sets of male–male dyads were investigated: 16 comprised an autistic Responder and a non-autistic Proposer, and 19 comprised non-autistic pairs of Responder and Proposer. Players' round-by-round behavior on the iUG was modeled as reciprocal choices, and dynamic functional connectivity (dFC) was measured to identify the neural mechanisms underpinning reciprocal behaviors. Behavioral expressions of reciprocity were significantly reduced in autistic compared with non-autistic Responders, yet no such differences were observed between the non-autistic Proposers in either set of dyads. Furthermore, we identified latent dFC states with temporal properties associated with reciprocity. Autistic interactants spent less time in brain states characterized by dynamic inter-network integration and segregation among the Default Mode Network and cognitive control networks, suggesting that their reduced expressions of social–emotional reciprocity reflect less efficient reconfigurations among brain networks supporting flexible cognition and behavior. These findings advance our mechanistic understanding of the social difficulties characterizing autism.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"725-740"},"PeriodicalIF":5.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waiting Times and Influencing Factors in Children and Adults Undergoing Assessment for Autism, ADHD, and Other Neurodevelopmental Differences","authors":"Donald Maciver,&nbsp;Anusua Singh Roy,&nbsp;Lorna Johnston,&nbsp;Marie Boilson,&nbsp;Eleanor Curnow,&nbsp;Victoria Johnstone-Cooke,&nbsp;Marion Rutherford","doi":"10.1002/aur.70011","DOIUrl":"10.1002/aur.70011","url":null,"abstract":"<p>This study explored waiting times and the factors influencing them in child and adult populations undergoing assessment for autism, ADHD, and other neurodevelopmental differences. The analysis focused on a retrospective review of 408 cases with assessments completed between October 2021 and May 2022, conducted by 30 diagnosing teams in Scotland. Data included age, final diagnosis, demographics, medical and developmental history, contact frequency, and assessment service adherence to best-practice standards. Waiting times were calculated, and relationships were analyzed using linear regression. Median waiting times were 525 days (IQR 329–857) for children/adolescents and 252 days (IQR 106–611) for adults. Only 20% of children's and 47% of adult assessments met the proposed 252-day diagnostic time target. Autism and ADHD were the most common diagnoses. Receiving &gt; 1 neurodevelopmental diagnosis on completion was uncommon. Demographic factors did not significantly affect waiting times. Children/adolescents with more complex developmental and medical histories experienced longer waits (100.3 weeks vs. 67.7 weeks; <i>p</i> &lt; 0.001), while adults with similar histories had shorter waits (32.7 weeks vs. 57.4 weeks; <i>p</i> = 0.016). Adults with ADHD experienced longer waits than autistic adults (63.4 weeks vs. 38.6 weeks, <i>p</i> = 0.002). Adherence to best-practice quality standards was associated with shorter waits for children (β = 0.27, p = 0.002), but the relationship between standard adherence at different stages and for adults was less clear. More frequent appointments correlated with shorter adult waits (33.7 weeks vs. 59.2 weeks, <i>p</i> = 0.015). Gender distribution was balanced among adults, but children's services included more boys. The study highlights long waits and the need for improvement in processes.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 4","pages":"788-801"},"PeriodicalIF":5.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parent Outcomes from a Randomized Controlled Trial Investigating a Modular Behavioral Intervention for Young Autistic Children","authors":"Lynne Levato,&nbsp;Samantha Hochheimer,&nbsp;Hongyue Wang,&nbsp;Lisa Wallace,&nbsp;Susan Hyman,&nbsp;Cynthia Anderson,&nbsp;Zachary Warren,&nbsp;Eric Butter,&nbsp;Ryan Martin,&nbsp;Evon Lee,&nbsp;Tristram Smith,&nbsp;Cynthia Johnson","doi":"10.1002/aur.70013","DOIUrl":"10.1002/aur.70013","url":null,"abstract":"<p>We assessed parent stress and competence outcomes from participation in a randomized controlled trial of a modular behavioral intervention (Modular Approach for Young Autistic Children; MAYAC) compared to a treatment-as-usual comprehensive behavioral intervention (CBI). Throughout their participation, parents of military families were included in their child's treatment (e.g., identifying goals, learning strategies to support their child) and reported on their feelings of stress using the Parenting Stress Index—4, Short Form (PSI-4), as well as their feelings of satisfaction and efficacy as a parent on the Parenting Sense of Competence (PSOC) scale. A linear mixed model evaluated the differences in stress and competence from baseline to each assessment period through follow-up. There were no significant differences between groups in stress or competence ratings; however, there were within-group changes in both treatment arms over the course of the trial. In both groups, parent stress decreased, and competence increased over time, continuing to suggest that behavioral analytic intervention for young children with autism can promote positive parent outcomes.</p><p>\u0000 <b>Trial Registration:</b> ClinicalTrial.gov identifier: NCT04078061</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 3","pages":"675-683"},"PeriodicalIF":5.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untangling the Molecular Mechanisms Contributing to Autism Spectrum Disorder Using Stem Cells","authors":"Zoe Mattingly,&nbsp;Sundari Chetty","doi":"10.1002/aur.70005","DOIUrl":"10.1002/aur.70005","url":null,"abstract":"<div>\u0000 \u0000 <p>Autism spectrum disorder (ASD) is a complex neuro developmental condition characterized by significant genetic and phenotypic variability, making diagnosis and treatment challenging. The heterogeneity of ASD-associated genetic variants and the absence of clear causal factors in many cases complicate personalized care. Traditional models, such as postmortem brain tissue and animal studies, have provided valuable insights but are limited in capturing the dynamic processes and human-specific aspects of ASD pathology. Recent advances in human induced pluripotent stem cell (iPSC) technology have transformed ASD research by enabling the generation of patient-derived neural cells in both two-dimensional cultures and three-dimensional brain organoid models. These models retain the donor's genetic background, allowing researchers to investigate disease-specific cellular and molecular mechanisms while identifying potential therapeutic targets tailored to individual patients. This commentary highlights how stem cell-based approaches are advancing our understanding of ASD and paving the way for more personalized diagnostic and therapeutic strategies.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 3","pages":"476-485"},"PeriodicalIF":5.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilingualism Effects in Metaphor and Simile Comprehension and Production in Children With Autism Spectrum Disorder","authors":"Maria Andreou,&nbsp;Stella Lampri,&nbsp;Theodoros Marinis,&nbsp;Eleni Peristeri","doi":"10.1002/aur.70009","DOIUrl":"10.1002/aur.70009","url":null,"abstract":"<p>Figurative language, including metaphors and similes, is a crucial component of communication; yet, it presents significant challenges for individuals with autism spectrum disorder (ASD). A critical gap in existing research is the impact of bilingualism on the ability of children with ASD to understand and produce non-literal speech. This study addresses this gap by examining the comprehension and production of metaphors and similes in monolingual and bilingual Greek-speaking children with high-functioning ASD. To the best of our knowledge, this is the first study to investigate these abilities in bilingual children with ASD. Thirty-three monolingual and 18 bilingual children participated in tasks designed to assess comprehension, production, and error patterns for metaphors and similes. The study has also investigated the roles of non-verbal intelligence, language skills (expressive vocabulary), and executive functions (working memory) in the children's performance in the metaphor and simile tasks. Results showed that the two groups did not differ in metaphor comprehension; however, bilingual autistic children with higher non-verbal intelligence appeared to have superior performance in metaphor comprehension compared to their bilingual peers with lower non-verbal intelligence. The bilingual autistic children outperformed their monolingual peers in metaphor production, likely due to their higher non-verbal intelligence ability, despite the fact that the bilingual group had lower expressive vocabulary scores than the monolingual children. Simile comprehension, on the other hand, favored monolingual children, while no significant group differences were observed in simile production. Regarding errors, both groups exhibited similar error patterns, with literal interpretations being the dominant error type across both groups, suggesting that pragmatic language difficulty is a hallmark feature in ASD. The findings challenge the misconception that bilingualism hinders language development in children with ASD and highlight its potential to provide benefits in the realm of non-literal language processing.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 3","pages":"632-647"},"PeriodicalIF":5.3,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Internal Consistency of the Autism Spectrum Disorder Gastrointestinal and Related Behaviors Inventory and the Frequency and Socio-Emotional Correlates of Gastrointestinal Difficulties in Children With the Autism Spectrum Disorder: A Cross-Sectional Study","authors":"Sanja Lestarevic,&nbsp;Marija Mihailovich,&nbsp;Milica Vlaisavljevic,&nbsp;Marko Kalanj,&nbsp;Roberto Grujicic,&nbsp;Vanja Mandic Maravic,&nbsp;Marija Mitkovic-Voncina,&nbsp;Calliope Holingue,&nbsp;Milica Pejovic-Milovancevic","doi":"10.1002/aur.70007","DOIUrl":"10.1002/aur.70007","url":null,"abstract":"<div>\u0000 \u0000 <p>Gastrointestinal (GI) difficulties are common in children diagnosed with autism spectrum disorder (ASD). However, these difficulties can frequently remain unrecognized. Therefore, we aimed to translate a newly developed instrument, <i>The Autism Spectrum Disorder Gastrointestinal and Related Behaviors Inventory in Children</i> (ASD-GIRBI), to assess its reliability and to explore the frequency of various gastrointestinal difficulties and related behaviors, as well as to explore the association of GI difficulties with the measures of social functioning and emotional and behavioral difficulties in children with ASD. A total of 98 children and adolescents (aged 4–18 [<i>M</i>\u0000 ^age = 10.67 ± 3.705], 82.7% male), previously diagnosed with ASD at the Institute of Mental Health in Belgrade, Serbia, took part in this research. Their parents filled out the following questionnaires: ASD-GIRBI (an assessment of gastrointestinal and related symptoms), Stanford Social Dimensions Scale (SSDS) (a measure of social functioning) and Strengths and Difficulties Questionnaire (SDQ) (a measure of emotional and behavioral problems). Our results indicate that the ASD-GIRBI is a reliable instrument for GI difficulties assessment (Cronbach's <i>α</i> = 0.841) with the total score successfully discriminating between the participants with and without a GI disorder diagnosis (<i>p</i> = 0.040). Any gastrointestinal symptom was present in 54.1% of the participants, most commonly flatulence, diarrhea, and constipation. The severity of gastrointestinal difficulties correlated to emotional problems (<i>r</i> = 0.261, <i>p</i> &lt; 0.01), conduct problems (<i>r</i> = 0.219, <i>p</i> &lt; 0.05), hyperactivity (<i>r</i> = 0.381, <i>p</i> &lt; 0.01), peer problems (<i>r</i> = 0.266, <i>p</i> &lt; 0.01), total difficulties (<i>r</i> = 0.454, <i>p</i> &lt; 0.01) and total difficulties impact (<i>r</i> = 0.321, <i>p</i> &lt; 0.01). Our data emphasize the potential importance of GI difficulties for various areas of functioning of individuals with ASD.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 3","pages":"515-527"},"PeriodicalIF":5.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Factor Structure and Validity of the Psychopathy Checklist-Short Version When Used With Autistic Psychiatric Inpatients","authors":"Kate Maguire,&nbsp;Magali Barnoux,&nbsp;Josie Collins,&nbsp;Clare L. Melvin,&nbsp;Ismay Inkson,&nbsp;Regi T. Alexander,&nbsp;John Devapriam,&nbsp;Conor Duggan,&nbsp;Lee Shepstone,&nbsp;Ekkehart Staufenburg,&nbsp;Paul Thompson,&nbsp;David Turner,&nbsp;Essi Viding,&nbsp;Peter E. Langdon","doi":"10.1002/aur.70004","DOIUrl":"10.1002/aur.70004","url":null,"abstract":"<p>The Psychopathy Checklist Short Version (PCL:SV) is a brief measure of psychopathy. This study aimed to assess the reliability and validity of the PCL:SV with autistic adults detained in inpatient psychiatric care. Data were collected from 282 autistic adults at two time points separated by 12-months. Reliability and validity were investigated using omega, regression, receiver operating characteristic curves, and correlational analysis. PCL:SV Total, Factor 1, and Factor 2 had satisfactory to high reliability and construct validity. Higher PCL:SV scores were associated with poorer treatment progress, a longer length of stay, and previous criminal offending. Factor 1 was associated with a forensic history, detention under Part III of the Mental Health Act, and a personality disorder diagnosis, while Factor 2 was also associated with the absence of a forensic history, detention under Part II of the Mental Health Act, but not a personality disorder diagnosis. It was thought that Factor 2 most likely captured data associated with autism and/or intellectual disabilities (e.g., behaviors that challenge). Those with intellectual disabilities were less likely to have convictions, a history of violent offending, or a forensic history. They were also more likely to be detained under Part II of the Mental Health Act, and were more likely to have had a positive transfer 12-months later to a ward with lesser security. The PCL-SV correlated as expected with the HCR-20 and the START. This study provides preliminary evidence to support the use of the PCL:SV with autistic adults, including those with intellectual disabilities, within inpatient psychiatric hospitals.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 3","pages":"614-631"},"PeriodicalIF":5.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}