Autism Research最新文献

{"title":"Is the Association Between Emotion Recognition and Social Functioning Mediated by Cognitive Empathy and Emotional Language? An Examination of School-Aged Autistic Children","authors":"Ifat Bar,&nbsp;Sigal Eden,&nbsp;Ofer Golan","doi":"10.1002/aur.70082","DOIUrl":"10.1002/aur.70082","url":null,"abstract":"<p>Children with autism spectrum disorder (ASD) face substantial challenges in understanding emotions, including difficulty in recognizing emotions through nonverbal cues, interpreting others' affective and mental states, and developing emotional vocabulary. Research suggests that the association between emotion recognition and social functioning is mediated by emotional language and cognitive empathy. However, this relationship remains underexplored in autistic children. Addressing this gap was the primary goal of this study, which comprised 116 autistic children (17 females), aged 7–10 (M = 8.26, SD = 0.76). Participants completed a comprehensive assessment battery, comprising multi-modal emotion recognition, cognitive empathy, and emotional language tasks. Social functioning was evaluated through naturalistic observations during free play, supplemented by a parent-reported standardized measure. Path analysis results revealed that after controlling for age, cognitive abilities, and autism severity, the relationship between emotion recognition and social functioning was mediated by cognitive empathy. Additionally, emotional language emerged as a contributing factor, enhancing cognitive empathy and further supporting its role in social functioning. These findings present an indirect path between emotion recognition and social functioning through emotional language and cognitive empathy, highlighting the importance of targeting these components in interventions aimed at promoting social communication and adaptive social skills in autistic children.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 9","pages":"1830-1839"},"PeriodicalIF":5.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study","authors":"Christina Luckhardt,&nbsp;Magdalena Schütz,&nbsp;Andreas M. Mühlherr,&nbsp;Sara Boxhoorn,&nbsp;Christine Ecker,&nbsp;Hanna Mössinger,&nbsp;Julia Siemann,&nbsp;Fabienne Schlechter,&nbsp;Miguel Castelo-Branco,&nbsp;Helena C. Pereira,&nbsp;Marianne Latinus,&nbsp;Camille Ricou,&nbsp;Frederique Bonnet-Brilhault,&nbsp;Ricardo Salvador,&nbsp;Giulio Ruffini,&nbsp;Rafal Nowak,&nbsp;Michael Siniatchkin,&nbsp;Astrid Dempfle,&nbsp;Christine M. Freitag","doi":"10.1002/aur.70084","DOIUrl":"10.1002/aur.70084","url":null,"abstract":"<p>Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (<i>N</i> = 12) or sham (<i>N</i> = 12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES] = 0.098; 95%-confidence interval [95% CI] −1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES = 1.106; 95% CI −0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732).</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 9","pages":"1861-1876"},"PeriodicalIF":5.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein-Altering Variants' Analysis in Autism Subgroups Uncovers Early Brain-Expressed Gene Modules Relevant to Autism Pathophysiology","authors":"Gaia Scaccabarozzi,&nbsp;Luca Fumagalli,&nbsp;Maddalena Mambretti,&nbsp;Roberto Giorda,&nbsp;Marco Villa,&nbsp;Silvia Busti Ceccarelli,&nbsp;Laura Villa,&nbsp;Elisa Mani,&nbsp;Maria Nobile,&nbsp;Massimo Molteni,&nbsp;Uberto Pozzoli,&nbsp;Alessandro Crippa","doi":"10.1002/aur.70086","DOIUrl":"10.1002/aur.70086","url":null,"abstract":"<p>Understanding the functional implications of genes' variants in autism heterogeneity is challenging. Gene set analysis examines the cumulative effect of multiple functionally converging genes. Here we explored whether a multi-step analysis could identify gene sets with different loads of protein-altering variants (PAVs) between two subgroups of autistic children. After subdividing our sample (<i>n</i> = 71, 3–12 years) based on higher (&gt; 80; <i>n</i> = 43) and lower (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>⩽</mo>\u0000 </mrow>\u0000 </semantics></math> 80; <i>n</i> = 28) intelligence quotient (IQ), a gene set variant enrichment analysis identified gene sets with significantly different incidence of PAVs between the two subgroups of autistic children. Significant gene sets were then clustered into modules of genes. Their brain expression was investigated according to the BrainSpan Atlas of the Developing Human Brain. Next, we extended each module by selecting the genes that were spatio-temporally co-expressed in the developing brain and physically interacting with those in modules. Last, we explored the incidence of autism susceptibility genes within original and extended modules. Our analysis identified 38 significant gene sets (FDR, <i>q</i> &lt; 0.05). They clustered in four modules involved in ion cell communication, neurocognition, gastrointestinal function, and immune system. Those modules were highly expressed in specific brain structures across development. Spatio-temporal brain co-expression and physical interactions identified extended genes' clusters with over-represented autism susceptibility genes. Overall, our unbiased approach identified modules of genes functionally relevant to autism pathophysiology, possibly implicating them in phenotypic variability across subgroups. The findings also suggest that autism diversity likely originates from multiple interacting pathways. Future research could leverage this approach to identify genetic pathways relevant to autism subtyping.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1535-1549"},"PeriodicalIF":5.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional Arousal-Induced Episodic Memory Benefits Are Attenuated in Autism Spectrum Disorders, Especially in Older Age","authors":"Sidni A. Justus,&nbsp;Emily Hutson,&nbsp;Justin Summe,&nbsp;Audrey Duarte","doi":"10.1002/aur.70083","DOIUrl":"10.1002/aur.70083","url":null,"abstract":"<p>Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder associated with episodic memory impairment. Although emotional factors such as arousal, as well as age and depression symptoms, are known to influence episodic memory in neurotypical (NT) populations, how these factors affect memory processes in ASD, which is associated with a higher prevalence of depression, remains unclear. In this large-scale online study, 326 adults (ages 18–67) with or without ASD (<i>n</i> = 163 per group) and varying levels of depressive symptoms rated their experienced arousal of positive, negative, and neutral images and performed a recognition task 48 h later. Adults with ASD reported lower arousal for positive images and exhibited reduced arousal-enhanced memory benefits for both positive and negative images compared to NT adults, independent of depression severity. Age further exacerbated this reduced arousal memory benefit in the ASD group, specifically for positive stimuli. These findings underscore the role of atypical emotional arousal in ASD on episodic memory, with age-related declines suggesting accelerated vulnerability in positive memory retention.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 9","pages":"1817-1829"},"PeriodicalIF":5.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Substance Use Disorder Among Autistic Youth With and Without Co-Occurring Mental Health Conditions and a History of Trauma","authors":"Jeanette M. Garcia,&nbsp;Kristy A. Anderson,&nbsp;John R. Moore,&nbsp;Tanya Renn,&nbsp;Jessica E. Rast","doi":"10.1002/aur.70081","DOIUrl":"10.1002/aur.70081","url":null,"abstract":"<div>\u0000 \u0000 <p>There is limited research on the prevalence of substance use disorders (SUDs) in autistic youth. Additionally, while mental health conditions and history of trauma have been associated with a higher prevalence of SUD in non-autistic youth, the research in autistic youth is scarce. Therefore, the purpose of this study was to examine the prevalence of SUDs in autistic youth compared to non-autistic youth with co-occurring mental health conditions and adverse childhood experiences. Data from 22,828 autistic youth and 601,348 non-autistic youth were drawn from the Child and Caregiver Linked Utilization and Outcomes Database (CCOULD). SUDs were identified using categorized ICD-10 diagnostic codes, and mental health comorbidities included six conditions (ADHD, anxiety, depression, bipolar disorder, schizophrenia/psychotic disorders, trauma/stress-related disorders), substantiated maltreatment allegations, and placement history. Overall prevalence of SUD was lower among autistic youth (1.7%) compared to non-autistic youth (3.8%, <i>p</i> &lt; 0.001). Both mental health comorbidities and maltreatment allegations were significantly associated with having a SUD, regardless of autism diagnosis. Placement in out-of-home care significantly reduced the likelihood of SUD among non-autistic youth (UOR = 0.83, 95% CI: 0.80–0.87) but more than doubled the odds among autistic youth (UOR = 2.36, 95% CI: 1.88–2.97). While prevalence rates of SUDs are lower in autistic youth compared to non-autistic youth, the presence of co-occurring mental health conditions and adverse childhood experiences may increase SUD rates to a greater extent in autistic youth. Future research should further investigate the complex relationships among SUDs, adverse childhood experiences, and mental health conditions in autistic youth.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1704-1713"},"PeriodicalIF":5.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Autistic “Linguatype”? Neologisms, New Words, and New Insights","authors":"Emily Zane,&nbsp;Rhiannon J. Luyster","doi":"10.1002/aur.70080","DOIUrl":"10.1002/aur.70080","url":null,"abstract":"<p>In this commentary, we present new ideas about autistic neologisms. This essay has two primary goals. First, we argue that an autistic predilection to form neologisms generates intriguing new hypotheses about language in autism, including the possibility that a tendency to use neologisms could be a featural element of an autistic “linguatype” (as in “phenotype”). Second, we suggest that the study of neologism meaning, form, and use can yield insights about a specific speaker and about autistic language, generally. To support both aims, we present the largest collection to date of autistic neologisms. We supply an initial framework for considering and analyzing them, and we apply this framework to some of our collected examples, showing how individual neologisms can offer insights about their creators. Importantly, we suggest that neologism creation may sometimes signify linguistic giftedness, pushing back against traditional notions suggesting autistic neologisms are always evidence of language deficit. We hope this exercise will convince our community that autistic neologisms are deserving of more scientific attention and study. More broadly, by demonstrating the potential value of one feature of autistic language, we aspire to advance collective appreciation for the complexity of autistic language and thought.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1518-1534"},"PeriodicalIF":5.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is the Impact of Second Language Exposure and Intellectual Disability Status on Executive Function and Functional Communication Outcomes in Children and Adolescents With and Without Autism Spectrum Disorder (ASD)?","authors":"Sarah M. Hutchison,&nbsp;Natalia DiazPinzon,&nbsp;Tim F. Oberlander,&nbsp;Grace Iarocci","doi":"10.1002/aur.70070","DOIUrl":"10.1002/aur.70070","url":null,"abstract":"<p>Over the past 10 years, research has suggested no negative effect on second language exposure in children with autism spectrum disorder (ASD), yet, parents and professionals may be concerned that using a second language with a child with ASD may negatively impact their communication and cognitive skills, especially if the child also has an intellectual disability. In this study, 396 children and adolesents (5–16 years) with and without ASD and with and without second language exposure participated in the study. Parents reported on language exposure and rated executive function (EF) and functional communication (FC) skills using a standardized questionnaire. IQ was directly measured using the WASI-II and children were classified as having an intellectual disability if they had a full-scale score of less than 70. The sample included 18 children with ASD and an intellectual disability (10 without second language exposure, 8 with second language exposure). Results showed that children with ASD and second language exposure had significantly better EF skills and were significantly less likely to have executive dysfunction in the clinical range than children with ASD with no second language exposure. Second language exposure also did not have a negative impact on EF skills in children with ASD even when an intellectual disability was present. For FC skills, we failed to find significant difference between children with ASD with and without second language exposure. For children with ASD and intellectual disability, there was no significant difference on FC skills between children with and without second language exposure. As our sample of children with ASD and intellectual disability was small, additional research with a larger sample is urgently needed.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 9","pages":"1805-1816"},"PeriodicalIF":5.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12442520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale","authors":"Xiaoyu Che,&nbsp;Xueqi Qu,&nbsp;Ramkripa Raghaven,&nbsp;Colleen Pearson,&nbsp;William Adams,&nbsp;Heather Volk,&nbsp;Marilyn Augustyn,&nbsp;Xiaobin Wang","doi":"10.1002/aur.70077","DOIUrl":"10.1002/aur.70077","url":null,"abstract":"<div>\u0000 \u0000 <p>While previous studies have examined the role of individual micronutrients in autism spectrum disorder (ASD), limited evidence exists on how maternal dietary patterns during pregnancy relate to broader social and communication outcomes. This study aimed to assess the association between adherence to a Mediterranean-style diet during pregnancy and measures of social impairment in a racially diverse, prospective birth cohort. We analyzed 821 mother–child pairs from the Boston Birth Cohort, including 52 children with an ASD diagnosis. Maternal Mediterranean-style Diet Scores (MSDS) during pregnancy were calculated using food frequency questionnaires administered 24–72 h after delivery. Child social impairment was assessed using Social Responsiveness Scale (SRS). Restricted cubic spline models were used to explore potential non-linear relationships between MSDS and SRS total scores. Linear regression models were used to quantify associations between MSDS tertiles and children's SRS total scores and scores across five SRS subdomains. An L-shape association was observed between maternal MSDS and SRS total scores. Compared to the children of mothers in the lowest MSDS tertiles, those in the middle (beta (95% CI) = −4.95 (−9.59, −0.31)) and highest tertiles (−5.13 (−9.48, −0.79)) had significantly lower SRS total scores, indicating reduced social impairment. Associations were particularly pronounced in the social cognition and social communication subdomains. Greater maternal adherence to a Mediterranean-style diet during pregnancy was associated with better social interaction and communication development in children. These findings underscore the critical role of maternal nutrition in child neurodevelopment, highlighting potential targets for early risk assessment and prevention efforts.</p>\u0000 </div>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1693-1703"},"PeriodicalIF":5.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male and Female Healthcare Trajectories in Autism: Are There Any Differences Considering Age at Diagnosis and Intellectual or Developmental Disabilities Status?","authors":"Mélanie Couture,&nbsp;Josiane Courteau,&nbsp;Sébastien Brodeur,&nbsp;Yohann M. Chiu,&nbsp;Mireille Courteau,&nbsp;Émilie Dubé,&nbsp;Nina Thomas,&nbsp; Alain Lesage,&nbsp;Éric Fombonne,&nbsp;Isabelle Dufour","doi":"10.1002/aur.70072","DOIUrl":"10.1002/aur.70072","url":null,"abstract":"<p>The aim of this study was to compare the healthcare trajectories (HCTs) 2 years after a first diagnosis of autism according to sex, age at diagnosis, and intellectual or developmental disabilities (IDD) status. This is a retrospective cohort study using health administrative data from Québec, Canada. The cohort included all individuals with a first diagnosis of autism registered by a physician between April 2012 and March 2015. HCTs were stratified by sex, presence of IDD, and age at diagnosis (youth, adult), and analyzed using state sequence analysis across healthcare settings, providers, and reasons for use. Our cohort included 5289 individuals, 76.6% were male, and 26.3% were adults at the time of diagnosis. The healthcare use decreased slightly over time, though intensity was higher in females. Sex differences in HCTs were strongly influenced by IDD status and age at diagnosis. While no significant sex differences were observed in HCTs for individuals with IDD diagnosed with autism in adulthood, the psychiatric condition profiles showed notable differences between males and females. Hospital days nearly doubled for females diagnosed in childhood compared to males, while males with IDD diagnosed with autism in childhood and males without IDD diagnosed in adulthood had fewer physical illness visits. Although physical and mental health challenges appear largely managed in ambulatory care during youth, high hospitalization rates in those diagnosed in adulthood, particularly females and those with IDD, highlight concerns about continuity of care and avoidable hospitalizations for these subgroups of patients.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1674-1692"},"PeriodicalIF":5.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aur.70072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Scene-Selectivity in the Retrosplenial Complex in Individuals With Autism Spectrum Disorder","authors":"Andrew S. Persichetti,&nbsp;Taylor L. Li,&nbsp;W. Dale Stevens,&nbsp;Alex Martin,&nbsp;Adrian W. Gilmore","doi":"10.1002/aur.70079","DOIUrl":"10.1002/aur.70079","url":null,"abstract":"<p>A small behavioral literature on individuals with autism spectrum disorder (ASD) has shown that they can be impaired when navigating using map-based strategies (i.e., memory-guided navigation), but not during visually-guided navigation. Meanwhile, there is neuroimaging evidence in typically developing (TD) individuals demonstrating that the retrosplenial complex (RSC) is part of a memory-guided navigation system, while the occipital place area (OPA) is part of a visually-guided navigation system. A key identifying feature of the RSC and OPA is that they respond significantly more to pictures of places compared to faces or objects—i.e., they demonstrate scene-selectivity. Therefore, we predicted that scene-selectivity would be weaker in the RSC of individuals with ASD compared to a TD control group, while the OPA would not show such a difference between the groups. We used functional MRI to scan groups of ASD individuals and matched TD individuals while they viewed pictures of places and faces and performed a one-back task. As predicted, scene-selectivity was significantly lower in the RSC, but not OPA, in the ASD group compared to the TD group. These results suggest that impaired memory-guided navigation in individuals with ASD may, in part, be due to atypical functioning in the RSC.</p>","PeriodicalId":131,"journal":{"name":"Autism Research","volume":"18 8","pages":"1563-1567"},"PeriodicalIF":5.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}